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Ibs and probiotics

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https://www.readbyqxmd.com/read/28732069/saccharomyces-boulardii-cncm-i-745-supplementation-reduces-gastrointestinal-dysfunction-in-an-animal-model-of-ibs
#1
Paola Brun, Melania Scarpa, Chiara Marchiori, Gloria Sarasin, Valentina Caputi, Andrea Porzionato, Maria Cecilia Giron, Giorgio Palù, Ignazio Castagliuolo
BACKGROUND: We evaluated the effect of Saccharomyces boulardii CNCM I-745 on intestinal neuromuscular anomalies in an IBS-type mouse model of gastrointestinal motor dysfunctions elicited by Herpes Simplex Virus type 1 (HSV-1) exposure. METHODS: Mice were inoculated intranasally with HSV-1 (102 PFU) or vehicle at time 0 and 4 weeks later by the intragastric (IG) route (108 PFU). Six weeks after IG inoculum, mice were randomly allocated to receive oral gavage with either S...
2017: PloS One
https://www.readbyqxmd.com/read/28729815/symposium-report-an-evidence-based-approach-to-ibs-and-cic-applying-new-advances-to-daily-practice-a-review-of-an-adjunct-clinical-symposium-of-the-american-college-of-gastroenterology-meeting-october-16-2016-%C3%A2-las-vegas-nevada
#2
William D Chey
Many nonpharmacologic and pharmacologic therapies are available to manage irritable bowel syndrome (IBS) and chronic idiopathic constipation (CIC). The American College of Gastroenterology (ACG) regularly publishes reviews on IBS and CIC therapies. The most recent of these reviews was published by the ACG Task Force on the Management of Functional Bowel Disorders in 2014. The key objective of this review was to evaluate the efficacy of therapies for IBS or CIC compared with placebo or no treatment in randomized controlled trials...
February 2017: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28640662/using-probiotics-in-clinical-practice-where-are-we-now-a-review-of-existing-meta-analyses
#3
Mariangela Rondanelli, Milena Anna Faliva, Simone Perna, Attilio Giacosa, Gabriella Peroni, Anna Maria Castellazzi
The scientific literature has demonstrated that probiotics have a broad spectrum of activity, although often the results are contradictory. This study provides a critical overview of the current meta-analyses that have evaluated the efficacy of probiotics in physiologic and pathological conditions, such as metabolic disease, antibiotic-associated and Clostridium difficile-associated diarrhea, IBS, constipation, IBD, chemotherapy-associated diarrhea, respiratory tract infection, ventilator-associated pneumonia, NAFLD, liver encephalopathy, periodontitis, depression, vaginosis, urinary tract infections, pancreatitis, incidence of ventilator-associated pneumonia, hospital infection and stay in ICU, mortality of post-trauma patients, necrotising enterocolitis in premature infants...
June 22, 2017: Gut Microbes
https://www.readbyqxmd.com/read/28638217/diet-in-irritable-bowel-syndrome-what-to-recommend-not-what-to-forbid-to-patients
#4
REVIEW
Anamaria Cozma-Petruţ, Felicia Loghin, Doina Miere, Dan Lucian Dumitraşcu
A substantial proportion of patients with irritable bowel syndrome (IBS) associate their symptoms with the ingestion of specific foods. Therefore, in recent years, scientific research has increasingly focused on the role of diet in IBS and dietary management is now considered an important tool in IBS treatment. This article reviews the main dietary approaches in IBS emphasizing evidence from experimental and observational studies and summarizing the main diet and lifestyle recommendations provided by dietary guidelines and scientific literature...
June 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28625832/diet-low-in-fodmaps-reduces-symptoms-in-patients-with-irritable-bowel-syndrome-and-probiotic-restores-bifidobacterium-species-a-randomized-controlled-trial
#5
H M Staudacher, M C E Lomer, F M Farquharson, P Louis, F Fava, E Franciosi, M Scholz, K M Tuohy, J O Lindsay, P M Irving, K Whelan
BACKGROUND & AIMS: Dietary restriction of fermentable carbohydrates (a low FODMAP diet) has been reported to reduce symptoms in some patients with irritable bowel syndrome (IBS). We performed a randomized, placebo-controlled study to determine its effects on symptoms and the fecal microbiota in patients with IBS. METHODS: We performed a 2x2 factorial trial of 104 patients with IBS (18-65 years old), based on the Rome III criteria, at 2 hospitals in the United Kingdom...
June 15, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28614379/microbiome-restoration-diet-improves-digestion-cognition-and-physical-and-emotional-wellbeing
#6
Kate Lawrence, Jeannette Hyde
Manipulating gut bacteria in the microbiome, through the use of probiotics and prebiotics, has been found to have an influence on both physical and emotional wellbeing. This study uses a dietary manipulation 'The Gut Makeover' designed to elicit positive changes to the gut bacteria within the microbiome. 21 healthy participants undertook 'The Gut Makeover' for a four week period. Weight and various aspects of health were assessed pre and post intervention using the Functional Medicine Medical Symptoms Questionnaire (MSQ)...
2017: PloS One
https://www.readbyqxmd.com/read/28536484/ibs-mindful-of-probiotics-for-psychiatric-comorbidities-in-ibs
#7
Katrina Ray
No abstract text is available yet for this article.
July 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28483500/probiotic-bifidobacterium-longum-ncc3001-reduces-depression-scores-and-alters-brain-activity-a-pilot-study-in-patients-with-irritable-bowel-syndrome
#8
Maria Ines Pinto-Sanchez, Geoffrey B Hall, Kathy Ghajar, Andrea Nardelli, Carolina Bolino, Jennifer T Lau, Francois-Pierre Martin, Ornella Cominetti, Christopher Welsh, Amber Rieder, Jenna Traynor, Caitlin Gregory, Giada De Palma, Marc Pigrau, Alexander C Ford, Joseph Macri, Bernard Berner, Gabriela Bergonzelli, Michael G Surette, Stephen M Collins, Paul Moayyedi, Premysl Bercik
BACKGROUND & AIMS: Probiotics can reduce symptoms of irritable bowel syndrome (IBS), but little is known about their effects on psychiatric comorbidities. We performed a prospective study to evaluate the effects of Bifidobacterium longum NCC3001 (BL) on anxiety and depression in patients with IBS. METHODS: We performed a randomized, double-blind, placebo-controlled study of 44 adults with IBS and diarrhea or a mixed-stool pattern (based on Rome III criteria) and mild to moderate anxiety and/or depression (based on the Hospital Anxiety and Depression scale) at McMaster University in Canada, from March 2011 to May 2014...
May 5, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28437458/isomalto-oligosaccharides-ameliorate-visceral-hyperalgesia-with-repair-damage-of-ileal-epithelial-ultrastructure-in-rats
#9
Weida Wang, Haiwei Xin, Xiucai Fang, Hongtao Dou, Fangyi Liu, Dan Huang, Shaomei Han, Guijun Fei, Liming Zhu, Shenghua Zha, Hong Zhang, Meiyun Ke
BACKGROUND: Treatment of irritable bowel syndrome (IBS) with probiotics has achieved effectiveness to a certain extent. Whether prebiotics will work is still unclear. This study aimed to investigate the therapeutic effects of the prebiotic isomalto-oligosaccharides (IMO) on visceral hypersensitivity (VHS) in rats and to explore potential mechanism. METHODS: Water avoidance stress (WAS) was used to induce VHS in rats. The score for the abdominal withdrawal reflex (AWR) was determined while colorectal distension and compared between VHS group and control group in order to validate VHS preparation...
2017: PloS One
https://www.readbyqxmd.com/read/28410580/lactobacillus-casei-dg-and-its-postbiotic-reduce-the-inflammatory-mucosal-response-an-ex-vivo-organ-culture-model-of-post-infectious-irritable-bowel-syndrome
#10
Debora Compare, Alba Rocco, Pietro Coccoli, Debora Angrisani, Costantino Sgamato, Barbara Iovine, Umberto Salvatore, Gerardo Nardone
BACKGROUND: The evidence on the role of gut microbiota in post-infectious irritable bowel syndrome (PI-IBS) is convincing. Lactobacillus spp. positively affect IBS symptoms, although the mechanisms through which probiotics exert their beneficial effects are largely unknown. The aim of the study is to evaluate the role of Lactobacillus casei DG (LC-DG) and its postbiotic (PB) in modulating the inflammatory/immune-response in PI-IBS in an ex-vivo organ culture model. METHODS: Ex vivo cultures of ileal and colonic mucosa from 10 PI-IBS, diarrhea predominant subtype (D) patients, and 10 healthy controls (HC) were treated with LPS, LC-DG and PB...
April 14, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28274108/small-intestinal-bacterial-overgrowth-and-irritable-bowel-syndrome-a-bridge-between-functional-organic-dichotomy
#11
REVIEW
Uday C Ghoshal, Ratnakar Shukla, Ujjala Ghoshal
The pathogenesis of irritable bowel syndrome (IBS), once thought to be largely psychogenic in origin, is now understood to be multifactorial. One of the reasons for this paradigm shift is the realization that gut dysbiosis, including small intestinal bacterial overgrowth (SIBO), causes IBS symptoms. Between 4% and 78% of patients with IBS and 1% and 40% of controls have SIBO; such wide variations in prevalence might result from population differences, IBS diagnostic criteria, and, most importantly, methods to diagnose SIBO...
March 15, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28271623/a-double-blind-placebo-controlled-study-to-assess-the-effect-of-a-probiotic-mixture-on-symptoms-and-inflammatory-markers-in-women-with-diarrhea-predominant-ibs
#12
K Hod, A D Sperber, Y Ron, M Boaz, R Dickman, S Berliner, Z Halpern, N Maharshak, R Dekel
BACKGROUND: Micro-inflammation is considered an element in the pathogenesis of irritable bowel syndrome (IBS). High-sensitivity C reactive protein (hs-CRP) was previously shown to be higher in IBS compared to healthy controls, albeit within the normal range. Since probiotics may suppress micro-inflammation in the gut, we tested if they reduce symptoms and inflammatory markers (hs-CRP and fecal calprotectin (FC) in diarrhea-predominant IBS (IBS-D). The aim of this study was to assess the clinical and laboratory effects of BIO-25, a multispecies probiotic, in women with IBS-D...
March 8, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28244666/when-the-low-fodmap-diet-does-not-work
#13
REVIEW
Emma P Halmos
Irritable bowel syndrome (IBS) is heterogeneous. Patients need proper assessment and explanation of IBS pathophysiology and appropriate therapies. A low FODMAP (fermentable oligosaccharides, disaccharides, monosaccharides, and polyols) diet effectively reduces symptoms in 75% of patients. Best treatment for those nonresponsive will depend on the pathophysiological basis for symptom genesis, with the following possible abnormalities: (i) Visceral hypersensitivity and/or enhanced gut-brain communication: a low FODMAP diet is mainly targeted for this patient group...
March 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28179092/altered-molecular-signature-of-intestinal-microbiota-in-irritable-bowel-syndrome-patients-compared-with-healthy-controls-a-systematic-review-and-meta-analysis
#14
REVIEW
Hai-Ning Liu, Hao Wu, Yu-Zhuo Chen, Yan-Jie Chen, Xi-Zhong Shen, Tao-Tao Liu
BACKGROUND: Many studies have reported significant changes in intestinal microbiota in irritable bowel syndrome (IBS) patients based on quantitative real-time PCR analysis. AIMS: We aimed to review the alterations in intestinal microbiota. METHODS: An online search up to June 9, 2016, was conducted. This systematic review and meta-analysis included differential expression of intestinal microbiota in patients with IBS versus healthy controls (HCs) and subgroup analysis...
April 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28166427/efficacy-of-bifidobacterium-infantis-35624-in-patients-with-irritable-bowel-syndrome-a-meta-analysis
#15
Fuqiang Yuan, Huijuan Ni, Carl V Asche, Minchul Kim, Saqib Walayat, Jinma Ren
BACKGROUND: The treatment of irritable bowel syndrome (IBS) is a challenge because its cause remains unknown. Previous clinical trials to examine the efficacy of probiotic Bifidobacterium infantis 35624 (B. infantis) in patients with IBS have shown inconsistent findings. This study aimed to assess the combined effect of B. infantis on reducing the symptom severity of IBS based on the published data. METHODS: A meta-analysis was conducted using fixed-effect models to estimate the combined effect of B...
March 7, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28108106/do-children-just-grow-out-of-irritable-bowel-syndrome
#16
Eleonora Giannetti, Marco Maglione, Elisa Sciorio, Vincenzo Coppola, Erasmo Miele, Annamaria Staiano
OBJECTIVE: Few data exist on natural history of irritable bowel syndrome (IBS) in children; therefore we investigated symptoms evolution over time in a cohort of children with IBS. STUDY DESIGN: In this observational, single-center study, we prospectively enrolled newly diagnosed children with IBS and reassessed them after 24 months. At both time points, patients completed a symptoms questionnaire, and a score of stool consistency was obtained. The therapeutic strategy adopted was also recorded...
April 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28087866/when-can-infants-and-children-benefit-from-probiotics
#17
Paul Dassow, Steven Fox
The latest studies indicate that probiotics can help with colic, eczema, and certain types of diarrhea. They may also help with upper respiratory infections and IBS pain.
November 2016: Journal of Family Practice
https://www.readbyqxmd.com/read/28070176/advances-in-ibs-2016-a-review-of-current-and-emerging-data
#18
Philip S Schoenfeld
Irritable bowel syndrome (IBS) is characterized by chronic intermittent abdominal pain and associated diarrhea (IBS-D), constipation (IBS-C), or both. IBS can significantly impact patient function and quality of life. The diagnosis of IBS is based on the presence of characteristic symptoms, the exclusion of concerning features, and selected tests to exclude organic diseases that can mimic IBS. The pathophysiology of IBS remains incompletely understood, and new contributing factors have been identified over the past decade...
August 2016: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27906800/lactobacillus-reuteri-dsm-17938-in-the-treatment-of-functional-abdominal-pain-in-children-rct-study
#19
Oleg Jadrešin, Iva Hojsak, Zrinjka Mišak, Alemka Jaklin Kekez, Tena Trbojević, Lana Ivković, Sanja Kolaček
OBJECTIVES: Beneficial therapeutic effect of probiotics has been reported in children with the irritable bowel syndrome (IBS) but not consistently in other functional abdominal pain-related disorders. The aim of the present study was to investigate the effect of Lactobacillus reuteri DSM 17938 in the treatment of functional abdominal pain (FAP) and IBS in children. METHODS: Children (age 4-18 years) referred to pediatric gastroenterologist at Children's Hospital Zagreb from May 2012 to December 2014, diagnosed as FAP or IBS, were randomized to receive L reuteri DSM 17938 10 CFU daily or placebo...
June 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27845337/multi-center-double-blind-randomized-placebo-controlled-parallel-group-study-to-evaluate-the-benefit-of-the-probiotic-bifidobacterium-infantis-35624-in-non-patients-with-symptoms-of-abdominal-discomfort-and-bloating
#20
RANDOMIZED CONTROLLED TRIAL
Tamar Ringel-Kulka, Johnson McRorie, Yehuda Ringel
OBJECTIVES: Bifidobacterium infantis 35624 is a probiotic that is used often in patients with irritable bowel syndrome (IBS). Non-patients with bowel symptoms may differ from patients with IBS in the impact of their bowel symptoms on illness severity, healthcare and treatment seeking behavior. The aim of this study is to assess the efficacy of B. infantis 35624 (10(9) c.f.u. per day) for the relief of abdominal discomfort and bloating in a non-patient population. METHODS: A double-blind, randomized, placebo-controlled, parallel study with a 2-week placebo run-in phase followed by a 4-week intervention phase was conducted at ten clinical centers (USA)...
January 2017: American Journal of Gastroenterology
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