Ye Guo, Zishu Wang, Huan Zhou, Hongming Pan, Weidong Han, Yanhong Deng, Qun Li, Junli Xue, Xiaoxiao Ge, Shuang Wang, Jing Wang, Yue Zhang, Congqiao Zhao, Huaqiang Zhu, Yu Wang, Haige Shen, Dong Liu, Jin Li
BACKGROUND: Transforming growth factor-β (TGF-β) is a cytokine with multiple functions, including cell growth regulation, extracellular matrix production, angiogenesis homeostasis adjustment and et al. TGF-β pathway activation promotes tumor metastasis/progression and mediates epithelial-mesenchymal transmission suppressing immunosurveillance in advanced tumors. GFH018, a small molecule inhibitor blocking TGF-β signal transduction, inhibits the progression and/or metastasis of advanced cancers...
April 10, 2024: BMC Cancer