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Epithelial mesenchymal transformation

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https://www.readbyqxmd.com/read/29339211/long-non-coding-rna-xist-promotes-tgf-%C3%AE-induced-epithelial-mesenchymal-transition-by-regulating-mir-367-141-zeb2-axis-in-non-small-cell-lung-cancer
#1
Chang Li, Liang Wan, Zeyi Liu, Guangquan Xu, Shengjie Wang, Zhiyue Su, Yingxi Zhang, Cuijuan Zhang, Xia Liu, Zhe Lei, Hong-Tao Zhang
Growing evidence shows that lncRNA XIST functions as an oncogene accelerating tumor progression. Transforming growth factor β (TGF-β)-induced epithelial-mesenchymal transition (EMT) plays a key role in tumor metastasis. However, it is still unclear whether lncRNA XIST is implicated in TGF-β-induced EMT and influences cell invasion and metastasis in non-small-cell lung cancer (NSCLC). Here, we observed increased expression of lncRNA XIST and ZEB2 mRNA in metastatic NSCLC tissues. Knockdown of lncRNA XIST inhibited ZEB2 expression, and repressed TGF-β-induced EMT and NSCLC cell migration and invasion...
January 12, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29337896/caffeic-acid-and-metformin-inhibit-invasive-phenotype-induced-by-tgf-%C3%AE-1-in-c-4i-and-htb-35-siha-human-cervical-squamous-carcinoma-cells-by-acting-on-different-molecular-targets
#2
Malgorzata Tyszka-Czochara, Malgorzata Lasota, Marcin Majka
During the progression of epithelial cancer, the cells may lose epithelial markers and gain mesenchymal phenotype via Epithelial-Mesenchymal Transition (EMT). Such transformation of epithelial cancer cells to mesenchymal-like characteristic benefits plasticity and supports their ability to migrate. The aim of this study was to evaluate the influence of natural compound Caffeic Acid (CA) alone and in combination with antidiabetic drug Metformin (Met) on metastatic progression of two human cervical squamous cell cancer lines, C-4I and HTB-35/SiHa cells...
January 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29336056/ilei-is-an-important-intermediate-participating-in-the-formation-of-tgf-%C3%AE-1-induced-renal-tubular-emt
#3
Xing Zhao, Gang Luo, Yan Fan, Xiaoxue Ma, Jieqing Zhou, Hong Jiang
Renal interstitial fibrosis is the most common process by which chronic kidney diseases progress to end-stage renal failure. Epithelial-to-mesenchymal transitions (EMTs) play a crucial role in the progression of renal interstitial fibrosis. A newly identified cytokine, interleukin-like EMT inducer (ILEI), has been linked to EMT in some diseases. However, the effects of ILEI on renal tubular EMT have not yet been well established. Here, we characterize the expression of ILEI in tubular EMT and describe the role and mechanism of ILEI in transforming growth factor beta 1 (TGF-β1)-induced renal tubular EMT...
January 15, 2018: Cell Biochemistry and Function
https://www.readbyqxmd.com/read/29330296/tumor-progression-is-mediated-by-thymosin-%C3%A3-4-through-a-tgf%C3%A3-mrtf-signaling-axis
#4
Tsuyoshi Morita, Kenichiro Hayashi
Although enhanced thymosin beta-ß4 (TMSBX4/Tß4) expression is associated with tumor progression and metastasis, its tumor-promoting functions remain largely unknown. Here it is demonstrated that transforming growth factor beta (TGFß) facilitates Tß4 expression and leads to the activation of myocardin-related transcription factors (MRTFs), which are co-activators of serum response factor (SRF) and regulate the expression of genes critical for the epithelial-mesenchymal transition (EMT) and tumor metastasis...
January 12, 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29326042/keratin-13-gene-is-epigenetically-suppressed-during-transforming-growth-factor-%C3%AE-1-induced-epithelial-mesenchymal-transition-in-a-human-keratinocyte-cell-line
#5
Mitsutoki Hatta, Yuki Miyake, Kunitoshi Uchida, Jun Yamazaki
Epithelial-mesenchymal transition (EMT) is a biological event in which epithelial cells lose their polarity and cell-cell adhesions and concomitantly acquire mesenchymal traits, and is thought to play an important role in pathological processes such as wound healing and cancer progression. In this study, we evaluated transforming growth factor (TGF)-β1-treated human keratinocyte HaCaT cells as an in vitro model of EMT. HaCaT cells were changed into an elongated fibroblast-like morphology, which is indicative of EMT in response to TGF-β1...
January 8, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29323181/oral-exposure-of-low-dose-bisphenol-a-promotes-proliferation-of-dorsolateral-prostate-and-induces-epithelial-mesenchymal-transition-in-aged-rats
#6
Dong-Yan Huang, Cheng-Cheng Zheng, Qi Pan, Shuang-Shuang Wu, Xin Su, Lei Li, Jian-Hui Wu, Zu-Yue Sun
Bisphenol A (BPA) is a well-known endocrine disruptor compound reported to have prostate toxicity. This study aimed to assess the effect of BPA on the proliferation of dorsolateral prostate (DLP) and the expression of epithelial-mesenchymal transition (EMT)-related genes in aged rats. Male aged SD rats were treated with BPA (10.0, 30.0, and 90.0 µg/kg i.g., daily) or vehicle (i.g., daily) for 3 months. Treatment with BPA resulted in increased the expression of PCNA, DLP weight and DLP epithelial height compared with the control group (P < 0...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29315388/galectin-3-and-cancer-stemness
#7
Pratima Nangia-Makker, Victor Hogan, Avraham Raz
Over the last few decades galectin-3, a carbohydrate binding protein, with affinity for N-acetyllactosamine residues, has been unique due to the regulatory roles it performs in processes associated with tumor progression and metastasis such as cell proliferation, homotypic/ heterotypic aggregation, dynamic cellular transformation, migration and invasion, survival and apoptosis. Structure-function association of galectin-3 reveals that it consists of a short amino terminal motif, which regulates its nuclear-cytoplasmic shuttling; a collagen α-like domain, susceptible to cleavage by matrix metalloproteases and prostate specific antigen (PSA); accountable for its oligomerization and lattice formation, and a carbohydrate recognition/binding domain containing the anti-death motif of the Bcl2 protein family...
January 5, 2018: Glycobiology
https://www.readbyqxmd.com/read/29311337/phenotypic-selection-as-the-biological-mode-of-epigenetic-conversion-and-reversion-in-cell-transformation
#8
Harry Rubin, Andrew L Rubin
Exposure of certain cell lines to methylcholanthrene, X-rays, or physiological growth constraint leads to preneoplastic transformation in all or most of the treated cells. After attaining confluence, a fraction in those cells progress to full transformation, as evidenced by their ability to form discrete foci distinguishable from the surrounding cells by virtue of their higher density. Transformation induced by suspension in agar, an even stronger growth-selective condition than confluence, is reminiscent of all but the final differentiated stage of a normal developmental process, epithelial-mesenchymal transition...
January 8, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29303507/t-cell-immune-regulator-1-enhances-metastasis-in-hepatocellular-carcinoma
#9
Hee Doo Yang, Jung Woo Eun, Kyung-Bun Lee, Qingyu Shen, Hyung Seok Kim, Sang Yean Kim, Dong-Wan Seo, Won Sang Park, Jung Young Lee, Suk Woo Nam
Recurrence and metastasis are major challenges in the management of hepatocellular carcinoma (HCC) patients after resection. To identify a metastasis-associated gene signature, we performed comparative gene expression analysis with recurrent HCC tissues from HCC patients who underwent partial or total hepatectomy and from non-metastatic primary HCC tissues. From this, we were able to identify genes associated with HCC recurrence. TCIRG1 (T-Cell Immune Regulator 1) was one of the aberrantly overexpressed genes in patients with recurrent HCC who had undergone total hepatectomy...
January 5, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29301325/extracorporeal-shock-wave-therapy-alters-the-expression-of-fibrosis-related-molecules-in-fibroblast-derived-from-human-hypertrophic-scar
#10
Hui Song Cui, A Ram Hong, June-Bum Kim, Joo Hyang Yu, Yoon Soo Cho, So Young Joo, Cheong Hoon Seo
Extracorporeal shock wave therapy (ESWT) considerably improves the appearance and symptoms of post-burn hypertrophic scars (HTS). However, the mechanism underlying the observed beneficial effects is not well understood. The objective of this study was to elucidate the mechanism underlying changes in cellular and molecular biology that is induced by ESWT of fibroblasts derived from scar tissue (HTSFs). We cultured primary dermal fibroblasts derived from human HTS and exposed these cells to 1000 impulses of 0...
January 2, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29298841/galectin-8-induces-partial-epithelial-mesenchymal-transition-with-invasive-tumorigenic-capabilities-involving-a-fak-egfr-proteasome-pathway-in-mdck-cells
#11
Claudia Oyanadel, Christopher Holmes, Evelyn Pardo, Claudio Retamal, Ronan Shaughnessy, Patricio Smith, Priscilla Cortes, Marcela Bravo-Zehnder, Claudia Metz, Teo Feuerhake, Diego Romero, Juan Carlos Roa, Viviana Montecinos, Andrea Soza, Alfonso González
Epithelial cells can acquire invasive and tumorigenic capabilities through epithelial-mesenchymal-transition (EMT). The glycan-binding protein Galectin-8 (Gal-8) is over-expressed by certain carcinomas and activates selective β1-integrins involved in EMT. Here we show that Gal-8 over-expression or exogenous addition promotes proliferation, migration and invasion in non-tumoral MDCK cells, involving focal-adhesion kinase (FAK)-mediated transactivation of the EGFR, likely triggered by α5β1integrin binding...
January 3, 2018: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/29296200/twist1-mediated-regulation-of-glioma-tumorigenicity-is-dependent-on-mode-of-mouse-neural-progenitor-transformation
#12
Andrei M Mikheev, Svetlana A Mikheeva, Mari Tokita, Liza J Severs, Robert C Rostomily
Twist1 is a master regulator of epithelial mesenchymal transition and carcinoma metastasis. Twist1 has also been associated with increased malignancy of human glioma. However, the impact of inhibiting Twist1 on tumorigenicity has not been characterized in glioma models in the context of different oncogenic transformation paradigms. Here we used an orthotopic mouse glioma model of transplanted transformed neural progenitor cells (NPCs) to demonstrate the effects of Twist1 loss of function on tumorigenicity. Decreased tumorigenicity was observed after shRNA mediated Twist knockdown in HPV E6/7 Ha-RasV12 transformed NPCs and Cre mediated Twist1 deletion in Twist1 fl/fl NPCs transformed by p53 knockdown and Ha-RasV12 expression...
December 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/29286127/autophagy-regulates-tgf-%C3%AE-2-induced-epithelial-mesenchymal-transition-in-human-retinal-pigment-epithelium-cells
#13
Jing Wu, Xiaoyun Chen, Xialin Liu, Shan Huang, Chang He, Baoxin Chen, Yizhi Liu
Transforming growth factor (TGF)-β2-induced epithelial-mesenchymal transition (EMT) in human retinal pigment epithelium (RPE) cells has an important role in the pathophysiology of intraocular fibrotic disorders, which may cause vision impairment and blindness. Autophagy, an intracellular homeostatic pathway, contributes to the physiological and pathological processes of RPE. Furthermore, autophagy has previously been reported to function in the EMT process in numerous tissue and cell types. However, the association between autophagy and the EMT process in RPE cells has not yet been fully determined...
December 27, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29286114/cigarette-smoke-induced-egfr-activation-promotes-epithelial-mesenchymal-migration-of-human-retinal-pigment-epithelial-cells-through-regulation-of-the-fak-mediated-syk-src-pathway
#14
Ga Bin Park, Daejin Kim
Epithelial-mesenchymal transition (EMT) of retinal pigment epithelial (RPE) cells is inevitable change of age‑related macular degeneration (AMD). Smoking is a major risk factor for the development of EMT in several diseases, including lung cancer. Cigarette smoke‑induced stress promotes the production of epidermal growth factor (EGF) in RPE cells. However, the underlying signaling pathways induced by aberrant EGF receptor (EGFR) expression in cigarette smoke-exposed RPE cells remain largely unknown. In the present study, the morphological transformation and production of EMT-associated cytokines were investigated to analyze the effect of smoking on the retina...
December 27, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29285358/ameloblastic-fibro-odontosarcoma-of-the-mandible-with-active-epithelial-proliferation-a-rare-case-report
#15
Haoman Niu, Junyu Liu, Yu Chen, Ning Geng
Ameloblastic fibro-odontosarcoma (AFOS) is an extremely rare subtype of odontogenic sarcoma, with no more than 19 cases reported in the English literature to date. AFOS is a biphasic neoplasm, with deposits of dentin and enamel matrix. We herein present a case of AFOS with active epithelial proliferation in a 31-year-old female patient. The patient was referred to the West China Hospital of Stomatology (Chengdu, China) due to a 6-month history of a swelling in the left mandible. Following clinical and radiological examination, the initial preoperative diagnosis was ameloblastoma, with local invasion and the possibility of malignant transformation...
December 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29285255/agrin-para-secreted-by-pdgf-activated-human-hepatic-stellate-cells-promotes-hepatocarcinogenesis-in-vitro-and-in-vivo
#16
Xing Lv, Cheng Fang, Ruozhe Yin, Bowei Qiao, Runze Shang, Jianlin Wang, Wenjie Song, Yong He, Yong Chen
Evaluating the process and mechanism of fibrogenesis is essential in hepatocellular carcinoma (HCC), especially in hepatocyte transformation and oncogenic signaling. We evaluated the oncogenic role of agrin secreted by platelet-derived growth factor (PDGF)-induced hepatic stellate cell (HSC) in HCC. Cells were co-cultured to investigate the effect of activated HSC on hepatocytes. Liquid chromatography and protein profiling analysis were used to search the distinct proteins secreted in HSC supernatant. Sprague Dawley rats with Diethylnitrosamine (DEN)-induced HCC were used to simulate human liver cancer and sorafenib was administered to investigate its effect on hepatocarcinogenesis...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29285218/doxycycline-inhibits-breast-cancer-emt-and-metastasis-through-par-1-nf-%C3%AE%C2%BAb-mir-17-e-cadherin-pathway
#17
Weilong Zhong, Shuang Chen, Yuan Qin, Heng Zhang, Hongzhi Wang, Jing Meng, Longcong Huai, Qiang Zhang, Tingting Yin, Yueyang Lei, Jingxia Han, Lingfei He, Bo Sun, Huijuan Liu, Yanrong Liu, Honggang Zhou, Tao Sun, Cheng Yang
Doxycycline displays high efficiency for cancer therapy. However, the molecular mechanism is poorly understood. In our previous study, doxycycline was found to suppress tumor progression by directly targeting proteinase-activated receptor 1 (PAR1). In this study, microRNAs were found to be involved in PAR1-mediated anti-tumor effects of doxycycline. Among these miRNAs, miR-17 was found to promote breast cancer cell metastasis both in vivo and in vitro. Moreover, miR-17 could reverse partial doxycycline inhibition effects on breast cancer...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29285087/scutellaria-barbata-d-don-inhibits-migration-and-invasion-of-colorectal-cancer-cells-via-suppression-of-pi3k-akt-and-tgf-%C3%AE-smad-signaling-pathways
#18
Yiyi Jin, Wujin Chen, Hong Yang, Zhaokun Yan, Zijun Lai, Jianyu Feng, Jun Peng, Jiumao Lin
Metastasis is one of the most aberrant behaviors of cancer cells. Patients with cancers, including colorectal cancer (CRC), have a higher risk of tumor recurrence and cancer-related mortality once metastasis is diagnosed. Existing treatment strategies fail to cure cancer mostly due to the onset of metastasis. Therefore, metastasis remains a challenge in cancer treatment. Some complementary and alternative medical therapies using traditional Chinese medicine have been demonstrated to be clinically effective in cancer treatment...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29284199/bone-marrow-mesenchymal-stem-cells-promote-head-and-neck-cancer-progression-through-periostin-mediated-pi3k-akt-mtor
#19
Chuanxia Liu, Xiaoxia Feng, Baixiang Wang, Xinhua Wang, Chaowei Wang, Mengfei Yu, Guifen Cao, Huiming Wang
Bone marrow mesenchymal stem cells (BMMSCs) have been shown to be recruited to tumor microenvironment and exert a tumor-promoting effect in a variety of cancers. However, the molecular mechanisms related to the tumor-promoting effect of BMMSCs on head and neck cancer (HNC) were not clear. In this study, we investigated Periostin (POSTN) and its roles in tumor-promoting effect of BMMSCs on HNC. In vitro analysis of HNC cells cultured in BMMSCs conditioned media (MSC-CM) showed that MSC-CM significantly promoted the cancer progression by enhancing cell proliferation, migration, epithelial-mesenchymal transformation (EMT), altering expression of cell cycle regulatory proteins and inhibition of apoptosis...
December 28, 2017: Cancer Science
https://www.readbyqxmd.com/read/29277653/microrna-191-regulated-by-hif-2%C3%AE-is-involved-in-emt-and-acquisition-of-a-stem-cell-like-phenotype-in-arsenite-transformed-human-liver-epithelial-cells
#20
Chao Chen, Qianlei Yang, Dapeng Wang, Fei Luo, Xinlu Liu, Junchao Xue, Ping Yang, Hui Xu, Jiachun Lu, Aihua Zhang, Qizhan Liu
Inorganic arsenic is widely distributed in the environment, and epidemiologic data show a strong association between arsenic exposure and risk of liver cancer. An understanding of the mechanisms underlying development of liver cancer and metastasis would be useful in reducing the incidence and mortality of liver cancer. MicroRNAs (miRs) act as regulators in liver cancer. Here, we show that acute or chronic exposure of human liver epithelial L-02 cells to arsenite increased expression of miR-191. There were decreased levels of BASP-1 and E-cadherin and increased levels of WT-1 and N-cadherin, indicating that arsenite induced epithelial-mesenchymal transition (EMT)...
December 22, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
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