Robin Magnard, Maxime Fouyssac, Yvan M Vachez, Yifeng Cheng, Thibault Dufourd, Carole Carcenac, Sabrina Boulet, Patricia H Janak, Marc Savasta, David Belin, Sebastien Carnicella
Impulse control disorders (ICDs), a wide spectrum of maladaptive behaviors which includes pathological gambling, hypersexuality and compulsive buying, have been recently suggested to be triggered or aggravated by treatments with dopamine D2/3 receptor agonists, such as pramipexole (PPX). Despite evidence showing that impulsivity is associated with functional alterations in corticostriatal networks, the neural basis of the exacerbation of impulsivity by PPX has not been elucidated. Here we used a hotspot analysis to assess the functional recruitment of several corticostriatal structures by PPX in male rats identified as highly (HI), moderately impulsive (MI) or with low levels of impulsivity (LI) in the 5-choice serial reaction time task (5-CSRTT)...
February 9, 2024: Translational Psychiatry