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https://www.readbyqxmd.com/read/29457114/a-pediatric-case-developing-critical-abdominal-distension-caused-by-a-combination-of-humidified-high-flow-nasal-cannula-oxygen-therapy-and-nasal-airway
#1
Satoki Inoue, Yumiko Tamaki, Shota Sonobe, Junji Egawa, Masahiko Kawaguchi
Background: We describe a pediatric patient who suffered from critical abdominal distention caused by a combination of humidified, high-flow nasal cannula (HHFNC) oxygen therapy and nasal airway. Case presentation: A 21-month-old boy with a history of chronic lung disease was admitted to the intensive care unit (ICU). Immediately after admission, his airway was established using a tracheal tube and mechanical ventilation was started. Five days after the commencement of mechanical ventilation, finally, his trachea was extubated...
2018: JA Clin Rep
https://www.readbyqxmd.com/read/29433886/expanding-the-donor-lung-pool-how-many-donations-after-circulatory-death-organs-are-we-missing
#2
William Zachary Chancellor, Eric J Charles, James Hunter Mehaffey, Robert B Hawkins, Carrie A Foster, Ashish K Sharma, Victor E Laubach, Irving L Kron, Curtis G Tribble
BACKGROUND: The number of patients with end-stage pulmonary disease awaiting lung transplantation is at an all-time high, while the supply of available organs remains stagnant. Utilizing donation after circulatory death (DCD) donors may help to address the supply-demand mismatch. The objective of this study is to determine the potential donor pool expansion with increased procurement of DCD organs from patients who die at hospitals. MATERIAL AND METHODS: The charts of all patients who died at a single, rural, quaternary-care institution between August 2014 and June 2015 were reviewed for lung transplant candidacy...
March 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29433570/role-of-atp-sensitive-potassium-channels-on-hypoxic-pulmonary-vasoconstriction-in-endotoxemia
#3
Maurizio Turzo, Julian Vaith, Felix Lasitschka, Markus A Weigand, Cornelius J Busch
BACKGROUND: ATP-regulated potassium channels (KATP) regulate pulmonary vascular tone and are involved in hypoxic pulmonary vasoconstriction (HPV). In patients with inflammation like sepsis or ARDS, HPV is impaired, resulting in a ventilation-perfusion mismatch and hypoxia. Since increase of vascular KATP channel Kir6.1 has been reported in animal models of endotoxemia, we studied the expression and physiological effects of Kir6.1 in murine endotoxemic lungs. We hypothesized that inhibition of overexpressed Kir6...
February 13, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29432140/noise-exposure-from-high-flow-nasal-cannula-oxygen-therapy-a-bench-study-on-noise-reduction
#4
Takamitsu Kubo, Hiroaki Nakajima, Ryo Shimoda, Tatsuya Seo, Yurie Kanno, Toshikazu Kondo, Sunao Tamai
BACKGROUND: High-flow nasal cannula (HFNC) oxygen therapy produces noise at a level such that patients often complain. However, the noise level has not been measured digitally. METHODS: We evaluated 3 types of HFNCs without filters and 2 types with filters attached for noise reduction. Optiflow (with and without a filter), MaxVenturi (with and without a filter) and AIRVO2 (without a filter only) were positioned at the center of a hospital room. We measured the noise levels at the distance of 1 m from the equipment at various total flows (30, 40, 50, 60 L/min) and F IO 2 (0...
February 6, 2018: Respiratory Care
https://www.readbyqxmd.com/read/29432138/characteristics-of-subjects-who-failed-a-120-minute-spontaneous-breathing-trial
#5
Guopeng Liang, Tingting Liu, Yihua Zeng, Yunfeng Shi, Wei Yang, Yunqin Yang, Yan Kang
BACKGROUND: The objective of this work was to identify the unique characteristics of patients who experienced success in a 30-min spontaneous breathing trial (SBT) but failed at 120 min. METHODS: Patients who had received mechanical ventilation for >24 h were eligible for inclusion in this study. The SBT was performed by 7 cm H 2 O of pressure support with zero PEEP. After a successful 120-min SBT, weaning from mechanical ventilation was performed. Data were collected at 30 and 120 min or at the failure of the SBT...
February 6, 2018: Respiratory Care
https://www.readbyqxmd.com/read/29432137/air-travel-for-subjects-receiving-long-term-oxygen-therapy
#6
Christina D Campbell, Matthew W Smyth, Lindsay Brown, Emer Kelly
BACKGROUND: Ambulatory oxygen (O2) is the recommended treatment for hypoxemia at rest or induced by exercise. Commercial aircraft often fly at altitudes of 30,000 feet; their cabins are pressurized to altitudes of 6,000-8,000 feet, with an equivalent FIO2 of 0.15.O2 supplementation, for those receiving baseline ambulatory O2, is paramount. METHODS: We gathered information on subjects' experience traveling with supplementary oxygen and reasons individuals receiving O2 do not travel...
February 6, 2018: Respiratory Care
https://www.readbyqxmd.com/read/29423544/high-intensity-interval-training-in-hypoxia-does-not-affect-muscle-hif-responses-to-acute-hypoxia-in-humans
#7
Stefan De Smet, Gommaar D'Hulst, Chiel Poffé, Ruud Van Thienen, Emanuele Berardi, Peter Hespel
PURPOSE: The myocellular response to hypoxia is primarily regulated by hypoxia-inducible factors (HIFs). HIFs thus conceivably are implicated in muscular adaptation to altitude training. Therefore, we investigated the effect of hypoxic versus normoxic training during a period of prolonged hypoxia ('living high') on muscle HIF activation during acute ischaemia. METHODS: Ten young male volunteers lived in normobaric hypoxia for 5 weeks (5 days per week, ~ 15.5 h per day, FiO2: 16...
February 8, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29421665/inhaled-hexadecyl-treprostinil-provides-pulmonary-vasodilator-activity-at-significantly-lower-plasma-concentrations-than-infused-treprostinil
#8
Richard W Chapman, Zhili Li, Michel R Corboz, Helena Gauani, Adam J Plaunt, Donna M Konicek, Franziska G Leifer, Charles E Laurent, Han Yin, Dany Salvail, Chad Dziak, Walter R Perkins, Vladimir Malinin
INS1009 is a long acting pulmonary vasodilator prodrug of treprostinil (TRE) that is formulated in a lipid nanoparticle for inhaled delivery by nebulization. This study examined the ability of INS1009 to inhibit vasoconstriction in the pulmonary vasculature of rats and dogs and the extent to which local activity within the lung contributes to its activity. Rats received a single dose of INS1009 by nose-only inhalation or were given a continuous intravenous (i.v.) infusion of TRE, followed by an i.v. challenge of the thromboxane mimetic pulmonary vasoconstrictor U46619 and the increase in pulmonary arterial pressure (PAP) was measured...
February 5, 2018: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29420848/why-do-children-with-severe-bronchopulmonary-dysplasia-not-attend-neonatal-follow-up-care-parental-views-of-barriers
#9
Jennifer M Brady, Nicole Pouppirt, Judy Bernbaum, Jo Ann D'Agostino, Marsha Gerdes, Casey Hoffman, Noah Cook, Hallam Hurt, Haresh Kirpalani, Sara B DeMauro
AIM: To assess in children with severe bronchopulmonary dysplasia at a corrected age of 18-36 months: 1)Neonatal follow-up clinic attendance rates; 2)Parent-identified reasons for difficulty attending neonatal follow-up. METHODS: Mixed methods study utilizing semi-structured phone interviews with parents of infants eligible for follow-up with severe bronchopulmonary dysplasia (defined as gestational age <32 weeks and requiring ≥30% FiO2 and/or > two liters nasal cannula at 36 weeks postmenstrual age) at 18-36 months corrected age...
February 8, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29420157/dynamic-cerebral-autoregulation-during-cognitive-task-effect-of-hypoxia
#10
Shigehiko Ogoh, Hiroki Nakata, Tadayoshi Miyamoto, Damian M Bailey, Manabu Shibasaki
Changes in cerebral blood flow (CBF) subsequent to alterations in the partial pressures of oxygen and carbon dioxide can modify dynamic cerebral autoregulation (CA). While cognitive activity increases CBF, to what extent it impacts CA remains to be established. In the present study we determined if dynamic CA would decrease during a cognitive task and whether hypoxia would further compound impairment. Fourteen young healthy subjects performed a simple Go/No-go task during normoxia and hypoxia (FIO2 =12%) and the corresponding relationship between mean arterial pressure (MAP) and mean middle cerebral artery blood velocity (MCA Vmean) was examined...
February 8, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29419895/pulmonary-artery-perfusion-versus-no-perfusion-during-cardiopulmonary-bypass-for-open-heart-surgery-in-adults
#11
REVIEW
Katrine B Buggeskov, Lars Grønlykke, Emilie C Risom, Mao Ling Wei, Jørn Wetterslev
BACKGROUND: Available evidence has been inconclusive on whether pulmonary artery perfusion during cardiopulmonary bypass (CPB) is associated with decreased or increased mortality, pulmonary events, and serious adverse events (SAEs) after open heart surgery. To our knowledge, no previous systematic reviews have included meta-analyses of these interventions. OBJECTIVES: To assess the benefits and harms of single-shot or continuous pulmonary artery perfusion with blood (oxygenated or deoxygenated) or a preservation solution compared with no perfusion during cardiopulmonary bypass (CPB) in terms of mortality, pulmonary events, serious adverse events (SAEs), and increased inflammatory markers for adult surgical patients...
February 8, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29415838/methods-to-validate-the-accuracy-of-an-indirect-calorimeter-in-the-in-vitro-setting
#12
Taku Oshima, Marco Ragusa, Séverine Graf, Yves Marc Dupertuis, Claudia-Paula Heidegger, Claude Pichard
INTRODUCTION: The international ICALIC initiative aims at developing a new indirect calorimeter according to the needs of the clinicians and researchers in the field of clinical nutrition and metabolism. The project initially focuses on validating the calorimeter for use in mechanically ventilated acutely ill adult patient. However, standard methods to validate the accuracy of calorimeters have not yet been established. This paper describes the procedures for the in-vitro tests to validate the accuracy of the new indirect calorimeter, and defines the ranges for the parameters to be evaluated in each test to optimize the validation for clinical and research calorimetry measurements...
December 2017: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29413724/characteristics-incidence-and-outcome-of-patients-admitted-to-intensive-care-unit-with-guillain-barre-syndrome-in-australia-and-new-zealand
#13
Paolo Ancona, Michael Bailey, Rinaldo Bellomo
PURPOSE: To describe characteristics, incidence and outcome of patients with Guillain-Barre syndrome (GBS) admitted to ICU. METHODS: We conducted a binational, retrospective, observational, epidemiological study. We compared the baseline characteristics, physiological conditions and outcomes for GBS patients with or without mechanical ventilation (MV) and of survivors and non-survivors. RESULTS: We studied 711 patients admitted to 173 ICUs between 2005 and 2015...
January 29, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/29406439/oxygen-and-preterm-infant-resuscitation-what-else-do-we-need-to-know
#14
Ju-Lee Oei, Ola D Saugstad, Maximo Vento
PURPOSE OF REVIEW: To evaluate current evidence for the use of lower or higher oxygen strategies for preterm infant resuscitation RECENT FINDINGS: The equipoise for using higher fraction of inspired oxygen (FiO2) (>0.4) to initiate preterm infant respiratory stabilization has been lost. Recent meta-analyses of randomized controlled trials assessing outcomes after using higher (FiO2 ≥ 0.6) vs. lower (FiO2 ≤ 0.3) oxygen strategies to initiate preterm resuscitation shows no difference in the rates of death or major morbidities...
February 5, 2018: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29406184/effect-of-preoxygenation-using-non-invasive-ventilation-before-intubation-on-subsequent-organ-failures-in-hypoxaemic-patients-a-randomised-clinical-trial
#15
C Baillard, G Prat, B Jung, E Futier, J Y Lefrant, F Vincent, A Hamdi, E Vicaut, S Jaber
BACKGROUND: Previous data showed that non-invasive ventilation (NIV) applied for 3 min before tracheal intubation ensured better oxygenation compared with using a non-rebreather bag-valve-mask. We aimed to determine whether preoxygenation using NIV is effective in reducing the incidence of organ dysfunction in hypoxaemic, critically ill patients in intensive care. METHODS: A multicentre, randomised, open-label trial evaluating 100% FiO 2 administered with NIV (99 patients) vs with face mask (102 patients) for 3 min before tracheal intubation...
February 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29404202/positive-end-expiratory-pressure-in-acute-hypoxemic-respiratory-failure-due-to-community-acquired-pneumonia-do-we-need-a-personalized-approach
#16
Valentina Paolini, Paola Faverio, Stefano Aliberti, Grazia Messinesi, Giuseppe Foti, Oriol Sibila, Anna Monzani, Federica De Giacomi, Anna Stainer, Alberto Pesci
Background: Acute respiratory failure (ARF) is a life-threatening complication in patients with community acquired pneumonia (CAP). The use of non-invasive ventilation is controversial. With this prospective, observational study we aimed to describe a protocol to assess whether a patient with moderate-to-severe hypoxemic ARF secondary to CAP benefits, in clinical and laboratoristic terms, from the application of a positive end expiratory pressure (PEEP) + oxygen vs oxygen alone. Methods: Patients who benefit from PEEP application (PEEP-responders) were defined as those with partial pressure of arterial oxygen to the fraction of inspired oxygen (PaO2/FiO2) increase >20% and/or reduction of respiratory distress during PEEP + oxygen therapy compared to oxygen therapy alone...
2018: PeerJ
https://www.readbyqxmd.com/read/29402688/respiratory-oxygen-uptake-is-associated-with-survival-in-a-cohort-of-ventilated-trauma-and-burn-patients
#17
Duraid Younan, Chee Paul Lin, Robert Johnson, Robert Clark, Lisa Smith, Jean-Francois Pittet, Mali Mathru, David W Miller
BACKGROUND: Little data is available in the literature about the role of end tidal oxygen in critically ill patients. We sought to identify the association between the level of respiratory oxygen and clinical outcomes in critically-ill ventilated trauma and burn patients. METHODS: A retrospective cohort of 55 trauma and burn patients from 2010 to 2016 was collected. Exposures of interest included a) expiratory end tidal oxygen (ETO2) and b) the difference between FiO2 and ETO2 (uptake)...
January 4, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29402365/-effect-and-mechanism-of-dexmedetomidine-on-lungs-in-patients-of-sepsis-complicated-with-acute-respiratory-distress-syndrome
#18
Xianfeng Chen, Juntao Hu, Chi Zhang, Yiping Pan, Diansheng Tian, Fafa Kuang, Zhanhong Tang
OBJECTIVE: To investigate the mechanisms of protective effects of dexmedetomidine on lungs in patients of sepsis complicated with acute respiratory distress syndrome (ARDS). METHODS: The adult patients with sepsis complicated with ARDS, the oxygenation index (PaO2/FiO2) was 150-200 mmHg (1 mmHg = 0.133 kPa), acute physiology and chronic health evaluation II (APACHE II) score was 10-20, need mechanical ventilation (MV) treatment > 72 hours, and admitted to intensive care unit (ICU) of the First Affiliated Hospital of Guangxi Medical University from September 2013 to June 2017 were enrolled...
February 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29402357/-predictive-factors-for-failure-of-non-invasive-positive-pressure-ventilation-in-immunosuppressed-patients-with-acute-respiratory-failure
#19
Xiangli Jia, Ci Yan, Sicheng Xu, Xingli Gu, Qiufeng Wan, Xinying Hu, Jingwen Li, Guangming Liu, Shareli Caikai, Zhijin Guo
OBJECTIVE: To evaluate the predictive factors for failure of non-invasive positive pressure ventilation (NIPPV) in immunosuppressed patients with acute respiratory failure (ARF). METHODS: The clinical data of 118 immuno-deficient patients treated with NIPPV in the respiratory and intensive care unit (RICU) of the First Affiliated Hospital of Xinjiang Medical University from January 2012 to August 2017 were retrospectively analyzed. The patients were divided into a non-endotracheal intubation (ETI) group (n = 62) and ETI group (n = 56) according to whether ETI was performed during the hospitalization period or not...
February 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29401336/cavh-in-the-combat-environment-a-case-report-and-lessons-learned-in-southern-afghanistan
#20
Jacob Glaser, Joseph Zeman, Stephen Noble, Nathanial Fernandez
Background: Acute kidney injury is a common complication of both civilian and military trauma. The lack of dedicated resources restrict dialysis in the forward setting. We report a case of a combat polytrauma and renal failure, using continuous arteriovenous hemofiltration to clear uremia and remove volume, allowing for ventilator liberation and safe disposition. Materials and Methods: The patient presented with traumatic lower extremity injuries and abdominal wounds and developed acute post-traumatic renal failure...
January 1, 2018: Military Medicine
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