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https://www.readbyqxmd.com/read/29777731/tumor-necrosis-factor-receptor-2-is-required-for-ischemic-preconditioning-mediated-neuroprotection-in-the-hippocampus-following-a-subsequent-longer-transient-cerebral-ischemia
#1
Jae-Chul Lee, Chan Woo Park, Myoung Cheol Shin, Jun Hwi Cho, Hyang-Ah Lee, Young-Myeong Kim, Joon Ha Park, Ji Hyeon Ahn, Jeong Hwi Cho, Hyun-Jin Tae, In Koo Hwang, Tae-Kyeong Lee, Moo-Ho Won, Il Jun Kang
Tumor Necrosis Factor-α (TNF-α) is a proinflammatory cytokine implicated in neuronal damage in response to cerebral ischemia. Ischemic preconditioning (IPC) provides neuroprotection against a subsequent severer or longer transient ischemia by ischemic tolerance. Here, we focused on the role of TNF-α in IPC-mediated neuroprotection against neuronal death following a subsequent longer transient cerebral ischemia (TCI). Gerbils used in this study were randomly assigned to eight groups; sham group, TCI operated group, IPC plus (+) sham group, IPC + TCI operated group, sham + etanercept (an inhibitor of TNF-a) group, TCI + etanercept group, IPC + sham + etanercept group, and IPC + TCI + etanercept group...
May 16, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29737303/curative-effect-of-oral-ulcer-powder-on-the-treatment-of-recurrent-aphthous-ulcer
#2
Shenshan Zhu, Qiaoyun Shi, Jian Lu
Recurrent aphthous ulcer (RAU) is a common and frequently occurring disease in the Department of Stomatology. The clinical manifestations are localized ulcer of oral mucosa, and the ulcer mask is self limiting and easy to recur. In this paper, by adopting the randomized study method, the author study the effect of oral ulcer powder combined with traditional Chinese drugs on patients with recurrent aphthous ulcer, and analyze its effect on inflammatory factor. Kangfuxin liquid combined with oral ulcer powder helps reduce recurrent aphthous ulcer patients the levels of inflammatory factors, improve the symptoms of pain...
May 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29735470/curative-effect-of-oral-ulcer-powder-on-the-treatment-of-recurrent-aphthous-ulcer
#3
Shenshan Zhu, Qiaoyun Shi, Jian Lu
Recurrent aphthous ulcer (RAU) is a common and frequently occurring disease in the Department of Stomatology. The clinical manifestations are localized ulcer of oral mucosa, and the ulcer mask is self limiting and easy to recur. In this paper, by adopting the randomized study method, the author study the effect of oral ulcer powder combined with traditional Chinese drugs on patients with recurrent aphthous ulcer, and analyze its effect on inflammatory factor. Kangfuxin liquid combined with oral ulcer powder helps reduce recurrent aphthous ulcer patients the levels of inflammatory factors, improve the symptoms of pain...
May 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29729380/effect-of-infusion-speed-of-7-5-hypertonic-saline-on-brain-edema-in-patients-with-craniocerebral-injury-an-experimental-study
#4
Zhenzhen Jiang, Hongmei Xu, Meilin Wang, Zefu Li, Xinyang Su, Xiaoli Li, Zhenzhu Li, Xuexin Han
This study firstly used a rat traumatic brain injury model to compare the therapeutic effects of different intravenous infusion speed of 7.5% hypertonic saline (HS). Then the authors applied different delivery rate of 7.5% HS to two groups of patients to figure out the optimal infusion rates. A total of 100 rats were randomly divided into control group, group A (7.5% HS 6 ml/h), group B (7.5% HS 3 ml/h), and group C (7.5% HS 2 ml/h). All rats were established for the brain injury model. A total of 30 patients were selected and randomly divided into group A (250 ml/h) and group B (125 ml/h), with 15 cases in each group...
May 2, 2018: Gene
https://www.readbyqxmd.com/read/29715536/evaluation-of-caco-2-cells-response-to-listeria-monocytogenes-virulence-factors-by-rt-pcr
#5
Manman Xie, Chengchao Ding, Liang Guo, Guowei Chen, Haijuan Zeng, Qing Liu
Listeria monocytogenes expresses various virulence factors enabling the invasion and multiplying in host cells, and together induces cytokines transcription. In order to explore the relationship between virulence factors of L. monocytogenes wild-type EGD-e and cellular response in human colonic epithelial cell line(Caco-2), we constructed mutant strains with in-frame deletions of critical virulence genes of inlA, inlB, hly, actA and virulence regulatory factor prfA from EGD-e, respectively. Compared with EGD-e, mutant strains showed significantly decreased invasion and apoptosis in Caco-2 cells...
April 28, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29713919/phosphodiesterase-4-and-7-inhibitors-produce-protective-effects-against-high-glucose-induced-neurotoxicity-in-pc12-cells-via-modulation-of-the-oxidative-stress-apoptosis-and-inflammation-pathways
#6
Nazanin Namazi Sarvestani, Saeedeh Saberi Firouzi, Reza Falak, Mohammad Yahya Karimi, Mohammad Davoodzadeh Gholami, Akram Rangbar, Asieh Hosseini
Diabetic neuropathy (DN) is the most common diabetic complication. It is estimated diabetic population will increase to 592 million by the year 2035. This is while at least 50-60% of all diabetic patients will suffer from neuropathy in their lifetime. Oxidative stress, mitochondrial dysfunction, apoptosis, and inflammation are crucial pathways in development and progression of DN. Since there is also no selective and effective therapeutic agent to prevent or treat high glucose (HG)-induced neuronal cell injury, it is crucial to explore tools by which one can reduce factors related to these pathways...
April 30, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29692266/insights-into-the-biological-evaluation-of-pterocarpanquinones-and-carbapterocarpans-with-anti-tumor-activity-against-mdr-leukemias
#7
Vivian M Rumjanek, Raquel C Maia, Eduardo J Salustiano, Paulo R R Costa
In an attempt to find anticancer agents that could overcome multidrug resistance (MDR), two new classes of modified isoflavonoids were designed and synthesized, and their effectiveness evaluated against a vast array of tumor cell lines. Pterocarpanquinone (LQB-118) and 11a-aza-5-carbapterocarpan (LQB-223) were the most promising. LQB-118 induced cell death, in vitro, in the mM range, to a number of human cancer cell lines as well as to fresh tumor cells obtained from patients with acute or chronic myeloid leukemia, independent on whether they exhibit or not the MDR phenotype...
April 20, 2018: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29677174/the-role-of-autophagy-and-the-chemokine-c-x-c-motif-ligand-16-during-acute-lung-injury-in-mice
#8
Ye Gao, Ni Wang, Rui H Li, Yang Z Xiao
BACKGROUND Acute lung injury (ALI) is responsible for mortality in hospitalized patients. Autophagy can negatively regulate inflammatory response, and CXCL16 (chemokine (C-X-C motif) ligand 16) is a kind of chemokine, which is closely related to the inflammatory response. However, the relationship between autophagy and CXCL16 in ALI is still unclear. This study aimed to investigate the role of autophagy and chemokine CXCL16 in ALI in mice. MATERIAL AND METHODS Thirty-two male C57BL/6 mice were divided into four groups...
April 20, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29652312/-a-study-on-the-association-of-genes-for-pro-inflammatory-cytokines-and-depression
#9
T V Lezheiko, A V Andryushchenko, G I Korovaitseva, N V Kondratiev, M V Gabaeva, E V Krikova, V E Golimbet
AIM: To study the association between proinflammatory cytokine genes and depression. MATERIAL AND METHODS: IL-1B С-511T and TNF-a G-308A gene polymorphisms were studied in patients diagnosed with depression and age and sex-matched healthy controls. RESULTS AND CONCLUSION: The IL-1B С-511T and TNF-a G-308A polymorphisms were associated with depression; CC genotype (р=0,001, OR=1.9 CI 1,3-2,7) and GG genotype (р=0,001, OR=3,0 CI 1,8-4,9) were the risk factors...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29650963/epigenetic-control-of-il-23-expression-in-keratinocytes-is-important-for-chronic-skin-inflammation
#10
Hui Li, Qi Yao, Alberto Garcia Mariscal, Xudong Wu, Justus Hülse, Esben Pedersen, Kristian Helin, Ari Waisman, Caroline Vinkel, Simon Francis Thomsen, Alexandra Avgustinova, Salvador Aznar Benitah, Paola Lovato, Hanne Norsgaard, Mette Sidsel Mortensen, Lone Veng, Björn Rozell, Cord Brakebusch
The chronic skin inflammation psoriasis is crucially dependent on the IL-23/IL-17 cytokine axis. Although IL-23 is expressed by psoriatic keratinocytes and immune cells, only the immune cell-derived IL-23 is believed to be disease relevant. Here we use a genetic mouse model to show that keratinocyte-produced IL-23 is sufficient to cause a chronic skin inflammation with an IL-17 profile. Furthermore, we reveal a cell-autonomous nuclear function for the actin polymerizing molecule N-WASP, which controls IL-23 expression in keratinocytes by regulating the degradation of the histone methyltransferases G9a and GLP, and H3K9 dimethylation of the IL-23 promoter...
April 12, 2018: Nature Communications
https://www.readbyqxmd.com/read/29650384/the-effect-of-combined-drugs-therapy-on-the-course-of-clinical-rabies-infection-in-a-murine-model
#11
Marcin Smreczak, Anna Orłowska, Anna Marzec, Paweł Trębas, Anna Kycko, Michał Reichert, Penelope Koraka, Albert D M E Osterhaus, Jan Franciszek Żmudziński
Rabies is a fatal disease of all mammals causing almost 60,000 human deaths every year. To date, there is no effective treatment of clinical rabies once the symptoms appear. Here, we describe the promising effect of combination therapy composed of molecules that target replication of the rabies virus (RV) at different stages of life cycle and molecules that inhibit some pathways of the innate host immune response accompanied by a blood-brain barrier opener on the outcome of RV infection. The study reports statistically significant extension of survival of mice treated with the drug cocktail containing T-705, ribavirin, interferon α/β, caspase-1 inhibitor, TNF-α inhibitor, MAPKs inhibitor and HRIG compared to the survival of mice in the virus control group (p = 0...
April 9, 2018: Vaccine
https://www.readbyqxmd.com/read/29623781/sildenafil-protective-effects-on-high-glucose-induced-neurotoxicity-in-pc12-cells-the-role-of-oxidative-stress-apoptosis-and-inflammation-pathways-in-an-in-vitro-cellular-model-for-diabetic-neuropathy
#12
Saeedeh Saberi Firouzi, Nazanin Namazi Sarvestani, Azam Bakhtiarian, Mahmoud Ghazi Khansari, Mohammad Yahya Karimi, Akram Ranjbar, Majid Safa, Asieh Hosseini
Objectives Diabetic neuropathy (DN) induces lifetime disability and there is currently no effective therapy to treat or to minimize patients suffering, so it is thereby imperative to develop therapeutic strategies for this disease. Since oxidative stress, mitochondrial dysfunction, apoptosis, and inflammation are crucial mechanisms in development and progression of DN, it is important to explore tools by which one can reduce factors related to these pathways. Herein, the understandings of the sildenafil neuroprotective effect through increase of cGMP level and the mediation of oxidative stress, apoptosis, and inflammation pathways on neurotoxicity induced by high glucose (HG) in PC12 cells as an in vitro cellular model for DN were investigated...
April 6, 2018: Neurological Research
https://www.readbyqxmd.com/read/29600800/hypertonic-saline-alleviates-brain-edema-after-traumatic-brain-injury-via-downregulation-of-aquaporin-4-in-rats
#13
Jian Yin, Haixiao Zhang, Huai Chen, Qingping Lv, Xuhong Jin
BACKGROUND Hypertonic saline (HS) has been successfully used for treatment of various forms of brain edema. Decreased expression of aquaporin (AQP)4 and pro-inflammatory cytokines such as tumor necrosis factor (TNF)-a and interleukin (IL)-1b have been linked to edema pathogenesis. This study examined the effect of 3% HS on brain edema in a rat model of traumatic brain injury (TBI). MATERIAL AND METHODS Sprague-Dawley rats were subjected to TBI induced by a controlled cortical impactor. The HS group was injected with 3% NaCl until the end of the study period...
March 30, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29600538/sb-216763-a-gsk-3%C3%AE-inhibitor-protects-against-aldosterone-induced-cardiac-and-renal-injury-by-activating-autophagy
#14
Yi-De Zhang, Xiao-Jun Ding, Hou-Yong Dai, Wei-Sheng Peng, Nai-Feng Guo, Yuan Zhang, Qiao-Ling Zhou, Xiao-Lan Chen
Cardiovascular and renal inflammation induced by Aldosterone (Aldo) plays a pivotal role in the pathogenesis of hypertension and renal fibrosis. GSK-3β contributes to inflammatory cardiovascular and renal diseases, but its role in Aldo-induced hypertension, and renal damage is not clear. In the present study, rats were treated with Aldo combined with SB-216763 (a GSK-3β inhibitor) for 4 weeks. Hemodynamic, cardiac, and renal parameters were assayed at the indicated time. Here we found that rats treated with Aldo presented cardiac and renal hypertrophy and dysfunction...
March 30, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29593717/tumor-necrosis-factor-%C3%AE-and-regulatory-t-cells-in-oncoimmunology
#15
REVIEW
Benoît L Salomon, Mathieu Leclerc, Jimena Tosello, Emilie Ronin, Eliane Piaggio, José L Cohen
Tumor necrosis factor α (TNF) is a potent pro-inflammatory cytokine that has deleterious effect in some autoimmune diseases, which led to the use of anti-TNF drugs in some of these diseases. However, some rare patients treated with these drugs paradoxically develop an aggravation of their disease or new onset autoimmunity, revealing an immunosuppressive facet of TNF. A possible mechanism of this observation is the direct and positive effect of TNF on regulatory T cells (Tregs) through its binding to the TNF receptor type 2 (TNFR2)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29576769/favorable-effect-of-anti-tnf-therapy-on-insulin-sensitivity-in-nonobese-nondiabetic-patients-with-inflammatory-bowel-disease
#16
Stavroula A Paschou, Fotios Kothonas, Apostolos Lafkas, Alexandros Myroforidis, Vasiliki Loi, Thomais Terzi, Olympia Karagianni, Androniki Poulou, Konstantinos Goumas, Andromachi Vryonidou
Background: The aim of this study was to investigate the effect of anti-TNF therapy on glucose and lipid metabolism in nondiabetic, nonobese patients with inflammatory bowel disease (IBD). Patients and Methods: We studied 44 patients with IBD, without a known history of diabetes. Three of the patients were diagnosed with overt diabetes and were excluded. Eighteen of the remaining patients (9 M/9 F, 33.6 ± 8.8 years) were on anti-TNF therapy for longer than 1 year, while 23 patients (16 M/7 F, 38...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29560933/-prognostic-significance-of-clinical-anthropometric-biochemical-metabolic-vascular-inflammatory-and-molecular-genetic-markers-in-the-development-of-the-first-ischemic-stroke
#17
V N Shishkova, T V Adasheva, A Yu Remenik, V N Valyaeva, V M Shklovsky
AIM: To study the relationship between clinical-anthropometric, biochemical, metabolic, vascular-inflammatory, molecular-genetic parameters and the development of the first ischemic stroke, and to develop a prognostic model for determining the probability of its occurrence. MATERIAL AND METHODS: The study included 196 first ischemic stroke patients and 119 healthy people matched for age, place of residence and nationality to the group of patients. The main anthropometric, clinical, biochemical, metabolic parameters and markers of vascular inflammation and endothelial dysfunction were assessed...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29554915/g908r-nod2-variant-in-a-family-with-sarcoidosis
#18
Valérie Besnard, Alain Calender, Diane Bouvry, Yves Pacheco, Catherine Chapelon-Abric, Florence Jeny, Hilario Nunes, Carole Planès, Dominique Valeyre
BACKGROUND: Sarcoidosis is a systemic disease characterized by the formation of immune granulomas in various organs, mainly the lungs and the lymphatic system. Exaggerated granulomatous reaction might be triggered in response to unidentified antigens in individuals with genetic susceptibility. The present study aimed to determine the genetic variants implicated in a familial case of sarcoidosis. METHODS: Sarcoidosis presentation and history, NOD2 profile, NF-κB and cytokine production in blood monocytes/macrophages were evaluated in individuals from a family with late appearance of sarcoidosis...
March 20, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29551980/integrative-computational-network-analysis-reveals-site-specific-mediators-of-inflammation-in-alzheimer-s-disease
#19
Srikanth Ravichandran, Alessandro Michelucci, Antonio Del Sol
Alzheimer's disease (AD) is a major neurodegenerative disease and is one of the most common cause of dementia in older adults. Among several factors, neuroinflammation is known to play a critical role in the pathogenesis of chronic neurodegenerative diseases. In particular, studies of brains affected by AD show a clear involvement of several inflammatory pathways. Furthermore, depending on the brain regions affected by the disease, the nature and the effect of inflammation can vary. Here, in order to shed more light on distinct and common features of inflammation in different brain regions affected by AD, we employed a computational approach to analyze gene expression data of six site-specific neuronal populations from AD patients...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29524303/tanshinone-iia-prevents-left-ventricular-remodelling-via-the-tlr4-myd88-nf-%C3%AE%C2%BAb-signalling-pathway-in-rats-with-myocardial-infarction
#20
Dong-Mei Wu, Yong-Jian Wang, Xin-Rui Han, Xin Wen, Lei Li, Lan Xu, Jun Lu, Yuan-Lin Zheng
In this study, we aim to investigate the role of tanshinone IIA in myocardial infarction (MI), especially in left ventricular remodelling (VR) and the underlying mechanism involving the TLR4/MyD88/NF-κB signalling pathway. Sprague-Dawley (SD) rats (n = 96) were selected, and 12 of them underwent sham surgery. The remaining 84 rats were subjected to MI modelling. HE and MT staining were carried out to estimate infract size, histopathological changes and fibrosis degree. Macrophage infiltration and cardiomyocyte apoptosis were evaluated by immunohistochemistry and TUNEL staining...
March 10, 2018: Journal of Cellular and Molecular Medicine
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