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https://www.readbyqxmd.com/read/29329680/correlation-of-severity-of-chronic-obstructive-pulmonary-disease-with-potential-biomarkers
#1
Seema Singh, S K Verma, Santosh Kumar, M K Ahmad, Anuradha Nischal, S K Singh, R K Dixit
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a non-specific inflammation, which involves the airways, lung parenchyma and pulmonary vessels. The inflammation causes the activation of inflammatory cells and the release of various inflammatory mediators such as interleukin-1 beta, interleukin-6 and tumor necrosis factor alpha (TNF-a). The present study was designed to assess the serum cytokines [Interleukin-1β (IL-1β), Interleukin-6 (IL-6), Tumor necrosis factor-α (TNF-α)] levels in chronic obstructive pulmonary disease (COPD) patients and they were correlated with severity of disease by spirometric measurements...
January 9, 2018: Immunology Letters
https://www.readbyqxmd.com/read/29315988/impaired-treg-and-nk-cells-profile-in-overweight-women-with-gestational-diabetes-mellitus
#2
Thalita Frutuoso Lobo, Camila de Moraes Borges, Rosiane Mattar, Caio Perez Gomes, Ana Geisa Santos de Angelo, Karen Priscilla Tezotto Pendeloski, Silvia Daher
PROBLEM: Maternal obesity is frequently associated with gestational diabetes mellitus (GDM), and immunological mechanisms seem to be involved in the physiopathology of these conditions. The aim of this study was to characterize the profile of immune cells in peripheral blood of overweight women with GDM. METHOD OF STUDY: This case-control study included 27 glucose-tolerant (controls) and 31 GDM overweight pregnant women. Flow cytometry was used to assess the number of regulatory T cells (Treg) and natural killer (NK) cells in the peripheral blood...
January 5, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29315760/protective-influence-of-rosiglitazone-against-testicular-ischaemia-reperfusion-injury-in-rats
#3
N Zheng, H Shao, D Wu, D Shen, X Lin
Testicular torsion is a urology urgent disease which causes testicular injury and potential sterility. In this study, we explored the protective influence of rosiglitazone on testicular ischaemia-reperfusion damage. There were 28 male Sprague Dawley rats in total, which were assigned randomly to four groups. Group A was blank control one; group B was testicular injury one; group C was rosiglitazone one; group D was rosiglitazone antagonist one. The testicles were counter-rotated after 2 hr and then underwent orchiectomy 24 hr later...
January 9, 2018: Andrologia
https://www.readbyqxmd.com/read/29298131/a-systematic-review-of-p53-regulation-of-oxidative-stress-in-skeletal-muscle
#4
Kaitlyn Beyfuss, David A Hood
BACKGROUND: p53 is a tumor suppressor protein involved in regulating a wide array of signaling pathways. The role of p53 in the cell is determined by the type of imposed oxidative stress, its intensity and duration. The last decade of research has unravelled a dual nature in the function of p53 in mediating the oxidative stress burden. However, this is dependent on the specific properties of the applied stress and thus requires further analysis. METHODS: A systematic review was performed following an electronic search of Pubmed, Google Scholar, and ScienceDirect databases...
January 3, 2018: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/29285702/pesticide-dichorvos-induces-early-solid-ehrlich-tumoral-development-associated-with-a-non-protective-pro-inflammatory-response
#5
Marcela Rodrigues de Camargo, Pedro Vinicius Teruya Akamine, James Venturini, Maria Sueli P de Arruda, Carla Adriene da Silva Franchi
Prolonged exposure to dichlorvos (DDVP), a common pesticide used for food crops, has been related to the development of infections and malignancies. Macrophages are used as bioindicators of immunotoxicity; thus, evaluation of their activity in solid Ehrlich tumor-bearing mice (TBM) may be useful to evaluate the influence of pesticides on human health. To investigate the effects of low DDVP doses, Swiss mice were divided into the following groups: the DDVP group, composed of mice fed diets containing 10 mg/kg of DDVP; the TBM group, consisting of mice subcutaneously inoculated with 107 tumor cells/100 μl and fed a basal diet; the DDVP-TBM group, consisting of mice previously fed DDVP-containing diets for 28 days and then subcutaneously inoculated with tumor cells; and the control (CTRL) group, composed of mice fed a basal diet...
December 28, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29284895/the-effects-of-aloe-vera-on-tnf-a-levels-the-percentage-of-nk-cells-and-th-17-cells-in-rat-that-received-izoniazid-and-rifampycin
#6
Herin Mawarti, Mukhamad Rajin, Zulfikar Asumta
Background: The present study was undertaken to investigate the hepatoprotective effect of Aloe vera against side effect of antituberculosis drug. Material and methods: Twenty-five rats will be divided into five groups, namely the control group (without any treatment), the group of rats treated with anti-tuberculosis drugs, and a group of rats were treated antituberculosis drugs and got Aloe vera extract at a dose of 40; 80; and 120 mg/kg body weight. Antituberculosis drugs are isoniazid and rifampicin a dose of 50 mg/kg body weight...
October 2017: Medical Archives
https://www.readbyqxmd.com/read/29278662/microrna-335-5p-suppresses-lower-extremity-deep-venous-thrombosis-by-targeted-inhibition-of-pai-1-via-the-tlr4-signaling-pathway
#7
Cui-Xia Bao, Dong-Xia Zhang, Na-Na Wang, Xiang-Kui Zhu, Qi Zhao, Xiao-Lei Sun
OBJECTIVE: This study aims to investigate the effects of microRNA-335-5p (miR-335-5p) on lower-extremity deep vein thrombosis (LEDVT) by targeting PAI-1 through the TLR4 signaling pathway in rat models. METHOD: siRNA, mimic and inhibitor were used for transfection. The miR-335-5p expression was detected by in situ hybridization. CCK-8 assay and flow cytometry were adopted to detect proliferation, cell cycle and apoptosis, respectively. Scratch test and Matrigel-based tube formation assay were used to detect the effect of miR-335-5p on cell migration ability and tube formation ability...
December 26, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29258450/serum-cytokine-profiles-predict-survival-benefits-in-patients-with-advanced-hepatocellular-carcinoma-treated-with-sorafenib-a-retrospective-cohort-study
#8
Tomoyuki Hayashi, Taro Yamashita, Takeshi Terashima, Tsuyoshi Suda, Hikari Okada, Yoshiro Asahina, Takehiro Hayashi, Yasumasa Hara, Kouki Nio, Hajime Sunagozaka, Hajime Takatori, Kuniaki Arai, Yoshio Sakai, Tatsuya Yamashita, Eishiro Mizukoshi, Masao Honda, Shuichi Kaneko
BACKGROUND: Sorafenib is a multiple receptor tyrosine kinase inhibitor known to prolong overall survival in patients with advanced hepatocellular carcinoma (HCC). Predicting this drug's survival benefits is challenging because clinical responses are rarely measurable during treatment. In this study, we hypothesized that serum cytokines levels could predict the survival of advanced HCC patients, as sorafenib targets signaling pathways activated in the tumor stromal microenvironment and potentially affects serum cytokine profiles...
December 19, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29258412/association-between-tnf-a-promoter-308g-a-polymorphism-and-essential-hypertension-in-the-asian-population-a-meta-analysis
#9
Ying-Shui Yao, Wei-Wei Chang, Yue-Long Jin
OBJECTIVE: The results of studies on the association between tumor necrosis factor-a -308G/A (TNF-a -308G/A) polymorphism, and susceptibility to essential hypertension are controversial. To derive a more precise estimation, we conducted a meta-analysis of all similar articles. METHODS: The summary effect odds ratios and 95% confidence intervals were obtained. Funnel plots and Egger's test were used to estimate publication bias, and heterogeneity was assessed by the chi-square-based Q-test and I2 test...
October 2017: Journal of the Renin-angiotensin-aldosterone System: JRAAS
https://www.readbyqxmd.com/read/29251622/-the-chemerin-production-changes-in-obese-patients-with-different-carbohydrate-metabolism-state
#10
M A Vasilenko, E V Kirienkova, D A Skuratovskaya, P A Zatolokin, N I Mironyuk, L S Litvinova
Chemerin is a mediator of adipose tissue involved in the regulation of many processes, including lipogenesis, and inflammatory response. The role of chemerin in the development of insulin resistance has been insufficiently studied and needs detailed understanding. The aim of the study was to investigate chemerin production in obese patients with different states of carbohydrate metabolism. The study included 155 patients with a diagnosis of obesity; 34 patients with overweight. The control group 1 consisted of 43 conditionally healthy donors who did not have obesity...
November 2017: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
https://www.readbyqxmd.com/read/29251618/-evaluation-of-adjuvant-effects-of-fucoidane-from-brown-seaweed-fucus-evanescens-and-its-structural-analogues-for-the-strengthening-vaccines-effectiveness
#11
T A Kuznetsova, L A Ivanushko, E V Persiyanova, A L Shutikova, S P Ermakova, M Yu Khotimchenko, N N Besednova
The use of sulfated polysaccharides from brown seaweed Fucus evanescens as adjuvants (native fucoidan in combination with polyphenols, fucoidan without polyphenols, a product of enzymatic hydrolysis of fucoidan) stimulated the formation of specific antibodies to the surface antigen of the hepatitis B virus (HBs-AG). Immunization of mice with vaccine compositions containing HBs-AG and fucoidan samples resulted in increasing the serum level of the pro-inflammatory (TNF-a, IFN-g, IL-2) cytokines. Increased production of these cytokines was detected in the culture of splenocytes additionally stimulated in vitro by fucoidans or phytohemagglutinin...
November 2017: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
https://www.readbyqxmd.com/read/29245360/does-increased-serum-d-lactate-mean-subclinical-hyperpermeability-of-intestinal-barrier-in-middle-aged-nonobese-males-with-osa
#12
Mulalibike Heizati, Nanfang Li, Liang Shao, Xiaoguang Yao, Yingchun Wang, Jing Hong, Ling Zhou, Delian Zhang, Guijuan Chang, Suofeiya Abulikemu
Few attention has been directed to the potential effects of intermittent hypoxia experienced in obstructive sleep apnea on the integrity and permeability of intestinal barrier, particularly in adults. Therefore, we evaluated alteration in serum d-lactate concentration in middle-aged males with obstructive sleep apnea to value permeability of intestinal barrier. In this current cross-sectional study, consecutive 159 males were studied. Obstructive sleep apnea was determined by polysomnography and apnea hypopnea index ≥15 event/h was defined as obstructive sleep apnea...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29241180/high-mobility-group-box1-inhibitor-glycyrrhizic-acid-attenuates-kidney-injury-in-streptozotocin-induced-diabetic-rats
#13
Hong Zhang, Ru Zhang, Juan Chen, Min Shi, Wei Li, Xiangcheng Zhang
BACKGROUND/AIMS: High mobility group box 1 (HMGB1) is an important mediator of the inflammatory response. It has been implicated in the pathogenesis of autoimmune diseases, atherosclerosis, and obesity. However, the effects of HMGB1 on diabetic nephropathy remain unclear. Here, we investigated the potential roles and mechanisms of an HMGB1 inhibitor, glycyrrhizic acid (GA), in renal injury with the streptozotocin (STZ)-induced rat model. METHODS: The diabetic rat was generated by intraperitoneal injection of STZ and then treated with the HMGB1 inhibitor GA or saline for 8 weeks...
November 15, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29219852/dietary-crocin-reverses-melanoma-metastasis
#14
Hamid A Bakshi, Faruck Lukmanul Hakkim, Smitha Sam, Farideh Javid
Crocus sativus and its bioactive constituent crocin are well known for anti-tumor potential in different models. However, the efficacy of crocin on in-vivo melanoma metastasis is not yet reported. In this study, melanoma metastatic model was developed by tail vein injection of B16F-10 cells in to C57BL/6 mice. Metastatic mice treated with two different doses of crocin (250 and 500 µg/kg of bodyweight) for 10 days and parameters such as lung metastasis inhibition, mean survival time, lung hydroxyproline, uronic acid and hexosamine levels were analyzed after 21 days of treatment...
November 1, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/29208272/biosynthesis-of-cerium-oxide-nanoparticles-and-their-effect-on-lipopolysaccharide-lps-induced-sepsis-mortality-and-associated-hepatic-dysfunction-in-male-sprague-dawley-rats
#15
Guoqiang Chen, Yunfei Xu
The fetal/life challenging Sepsis is an urgent medical disaster which have developed "blood poisoning". The sepsis is one of the disorders of organs which cause death in patients. The investigational models that mimicchemical change of sepsis in human bodywereessential. We have synthesized CeO2 NPs using eco-friendly method using plant extract. The characterization of synthesized CeO2 NPs was studied using UV-Vis, FTIR, XRD, SEM, EDX and TEM analysis. The results were confirmed that the synthesized CeO2 was in nano size with spherical shape...
February 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29207957/placenta-response-of-inflammation-and-oxidative-stress-in-low-risk-term-childbirth-the-implication-of-delivery-mode
#16
Yabin Hu, Kun Huang, Yuanfang Sun, Jianqing Wang, Yeqing Xu, Shuangqin Yan, Peng Zhu, Fangbiao Tao
BACKGROUND: Caesarean delivery rate is increasing gradually in China and there is no doubt that delivery mode is closely associated with the maternal health and infant development.This study examined the independent effect of delivery mode on placenta inflammation response and oxidative stress response. METHODS: A total of 3474 pregnant women recruited in Ma'anshan Birth Cohort Study were the initial study population. Data on maternal socio-demographic characteristics and pre-pregnancy BMI were collected at their 1st antenatal checkups...
December 6, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29197221/mirna-21-expression-in-the-serum-of-elderly-patients-with-acute-myocardial-infarction
#17
Zhong-Hua Wang, Xin-Yong Sun, Chun-Lei Li, Yan-Ming Sun, Jia Li, Lan-Feng Wang, Zhu-Qin Li
BACKGROUND The aims of this study were to examine the expression of miRNA-21 in the serum of elderly patients (>65 years) with acute myocardial infarction (AMI) and to investigate the potential role of serum miRNA-21 as a marker of early cardiac myocyte damage. MATERIAL AND METHODS Thirty-eight elderly patients with recent AMI, 27 elderly patients with unstable angina pectoris, and 25 healthy elderly individuals were included in the study. Serum miRNA-21 expression was determined following total RNA extraction and reverse-transcribed into cDNA, followed by reverse transcription-polymerase chain reaction (RT-PCR)...
December 2, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29183784/osteocalcin-improves-insulin-resistance-and-inflammation-in-obese-mice-participation-of-white-adipose-tissue-and-bone
#18
J A C Guedes, J V Esteves, M R Morais, T M Zorn, D T Furuya
AIMS/HYPOTHESIS: The discovery of osteocalcin, a protein synthetized by osteoblasts, as a hormone that has positive effects on insulin resistance, contributed to support the concept of bone as an endocrine organ. However, very little is known about the molecular pathways involved in osteocalcin improved-insulin resistance. The present study aimed to investigate the mechanisms of action of osteocalcin on insulin resistance and inflammation in obese mice and 3T3-L1 adipocytes. METHODS AND RESULTS: Lean control, saline-treated obese and uncarboxylated osteocalcin (uOC)-treated obese mice were subjected to insulin tolerance test in vivo...
November 26, 2017: Bone
https://www.readbyqxmd.com/read/29180332/-effect-of-dexmedetomidine-postconditioning-on-myocardial-ischemia-reperfusion-injury-and-inflammatory-response-in-diabetic-rats
#19
Jing Hu, Xiao-Yu Gu, Yan Meng, Ya Wang, Qin Gao, Zheng-Hong Li, Xiao-Hong Li, Xiang-Yang Cheng
OBJECTIVE: To investigate the effect of dexmedetomidine postconditioning in alleviating myocardial ischemia-reperfusion (IR) injury and inflammation in diabetic mellitus rats. METHODS: Thirty normal male Sprauge Dawley (SD) rats were randomly allocated into 3 groups (n=10), namely the sham-operated group, IR group, and dexmedetomidine postconditioning (DP) group. Similarly, another thirty diabetic SD rats were also randomly allocated into diabetic sham (DM-S) group, diabetic IR (DM-IR) group and diabetic dexmedetomidine postconditioning (DM-DP) group...
November 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/29174983/comparison-of-hepatic-transcriptome-profiling-between-acute-liver-injury-and-acute-liver-failure-induced-by-acetaminophen-in-mice
#20
Chunmin Li, Yanan Ming, Wenting Hong, Yingyue Tang, Xiaohong Lei, Xiaobo Li, Yimin Mao
Acetaminophen (APAP) overdose is a leading cause of drug-induced acute liver failure in many countries. In the present study, we developed stable mouse models of acute drug-induced hepatic injury (DILI) and acute drug-induced hepatic failure (DILF) by sub-lethal and lethal APAP injection respectively. The differences in hepatic transcriptome profiling between these two models were compared by RNA sequencing, which were validated by qPCR, western-blot and ELISA. In results, serum IL-6, TNF-a and IL-10 levels are higher in DILF than in DILI...
November 23, 2017: Toxicology Letters
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