keyword
https://read.qxmd.com/read/38535612/fungemia-by-wickerhamomyces-anomalus-a-narrative-review
#1
REVIEW
Petros Ioannou, Stella Baliou, Diamantis P Kofteridis
Wickerhamomyces anomalus has been previously classified as Hansenula anomala , Pichia anomala , and Candida pelliculosa and was recently reclassified in the genus Wickerhamomyces after phylogenetic analysis of its genetic sequence. An increasing number of reports of human infections by W. anomalus have emerged, suggesting that this microorganism is an emerging pathogen. The present review aimed to provide data on the epidemiology, antifungal resistance, clinical characteristics, treatment, and outcomes of fungemia by W...
March 21, 2024: Pathogens
https://read.qxmd.com/read/38535577/-staphylococcus-capitis-central-line-associated-bloodstream-infections-in-the-neonatal-intensive-care-unit-a-single-center-four-year-experience-in-central-line-management-during-sepsis-treatment
#2
JOURNAL ARTICLE
Anna Sala, Valentina Pivetti, Alessandra Vittorini, Claudia Viggiano, Francesca Castoldi, Valentina Fabiano, Gianluca Lista, Francesco Cavigioli
Coagulase-negative staphylococci (CoNS) are reportedly responsible for 50-60% of bloodstream infections in very preterm (<1500 g) infants in neonatal intensive care units (NICUs). Staphylococcus capitis is an increasingly prevalent pathogen in the neonatal setting, frequently causing central-line-associated bloodstream infections (CLABSIs) that can be difficult to eradicate. Central venous catheter (CVC) removal versus in situ treatment with CoNS CLABSIs is a controversial treatment strategy with no clear consensus...
March 7, 2024: Pathogens
https://read.qxmd.com/read/38518044/analysis-and-risk-factors-of-deep-vein-catheterization-related-bloodstream-infections-in-neonates
#3
JOURNAL ARTICLE
Yan Zhang, Shufang Li, Yanmin Li, Jiaojiao Zheng, Yaping Dong
To investigate the incidence, risk factors, and pathogenic characteristics of catheter-related bloodstream infection caused by peripherally inserted central venous catheter in neonates, and to provide references for reducing the infection rate of peripherally inserted central venous catheter. The clinical data of 680 neonates who underwent peripherally inserted central catheter (PICC) in the neonatal intensive care unit from June 2020 to June 2023 were retrospectively analyzed. The risk factors and independent risk factors of catheter-related bloodstream infection caused by PICC were determined by univariate and multivariate analysis, respectively...
March 22, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38514673/invasive-candidiasis
#4
REVIEW
Cornelia Lass-Flörl, Souha S Kanj, Nelesh P Govender, George R Thompson, Luis Ostrosky-Zeichner, Miriam Alisa Govrins
Invasive candidiasis is an important fungal disease caused by Candida albicans and, increasingly, non-albicans Candida pathogens. Invasive Candida infections originate most frequently from endogenous human reservoirs and are triggered by impaired host defences. Signs and symptoms of invasive candidiasis are non-specific; candidaemia is the most diagnosed manifestation, with disseminated candidiasis affecting single or multiple organs. Diagnosis poses many challenges, and conventional culture techniques are frequently supplemented by non-culture-based assays...
March 21, 2024: Nature Reviews. Disease Primers
https://read.qxmd.com/read/38510847/the-effect-of-taurolidine-on-the-time-to-positivity-of-blood-cultures
#5
JOURNAL ARTICLE
C H van den Bosch, J E P Moree, S Peeters, M Lankheet, A F W van der Steeg, M H W A Wijnen, M D van de Wetering, J T van der Bruggen
BACKGROUND: Taurolidine containing lock solutions (TL) are a promising method for the prevention of central line associated bloodstream infections. Per accident, the TL may not always be aspirated from the central venous catheter (CVC) before blood cultures are obtained. The TL could, unintentionally, end up in a blood culture vial, possibly altering the results. The aim of this study was to investigate the effect of the TLs on the detection of microbial growth in blood culture vials...
June 2024: Infection prevention in practice
https://read.qxmd.com/read/38510214/a-review-on-antimicrobial-strategies-in-mitigating-biofilm-associated-infections-on-medical-implants
#6
REVIEW
Lohita Kadirvelu, Sowmiya Sri Sivaramalingam, Deepsikha Jothivel, Dhivia Dharshika Chithiraiselvan, Deenadayalan Karaiyagowder Govindarajan, Kumaravel Kandaswamy
Biomedical implants are crucial in providing support and functionality to patients with missing or defective body parts. However, implants carry an inherent risk of bacterial infections that are biofilm-associated and lead to significant complications. These infections often result in implant failure, requiring replacement by surgical restoration. Given these complications, it is crucial to study the biofilm formation mechanism on various biomedical implants that will help prevent implant failures. Therefore, this comprehensive review explores various types of implants (e...
2024: Current research in microbial sciences
https://read.qxmd.com/read/38506890/risk-of-infections-related-to-endovascular-catheters-and-cardiac-implantable-devices-in-hemodialysis-patients
#7
REVIEW
Gaetano Alfano, Niccolò Morisi, Silvia Giovanella, Monica Frisina, Alessio Amurri, Lorenzo Tei, Maria Ferri, Giulia Ligabue, Gabriele Donati
Patients requiring dialysis are extremely vulnerable to infectious diseases. The high burden of comorbidities and weakened immune system due to uremia and previous immunosuppressive therapy expose the patient on dialysis to more infectious events than the general population. The infectious risk is further increased by the presence of endovascular catheters and implantable cardiologic devices. The former is generally placed as urgent vascular access for dialysis and in subjects requiring hemodialysis treatments without autogenous arteriovenous fistula...
March 20, 2024: Journal of Vascular Access
https://read.qxmd.com/read/38502709/regulatory-considerations-in-the-approval-of-rezafungin-rezzayo-for-the-treatment-of-candidemia-and-invasive-candidiasis-in-adults
#8
JOURNAL ARTICLE
Heidi L Smith, Timothy J Bensman, Shrimant Mishra, Xianbin Li, Cheryl A Dixon, Jalal Sheikh, Owen G McMaster, Abhay Joshi, Daniel B Rubin, Avery Goodwin, Terry J Miller, Zhixia Y Danielsen, Irum Syed, Sunita J Shukla, Dmitri Iarikov, Peter W Kim, John J Farley
On March 22, 2023, the FDA approved rezafungin (REZZAYO) for the treatment of candidemia and invasive candidiasis in adults with limited or no alternative treatment options. Rezafungin is an echinocandin that supports weekly dosing, enabling outpatient parenteral treatment that potentially avoids the need for a central venous catheter. Approval of rezafungin was based on a single adequate and well-controlled phase 3 study designed with a Day 30 all-cause mortality primary endpoint and 20% noninferiority margin, which demonstrated that rezafungin is noninferior to the comparator echinocandin...
March 19, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38500715/resources-needed-by-critical-access-hospitals-to-address-identified-infection-prevention-and-control-program-gaps
#9
JOURNAL ARTICLE
Mounica Soma, Jody Scebold, Angela Vasa, Teresa Ann Fitzgerald, Kate Tyner, Satya Kumar Lalam, Sue Beach, Muhammad Salman Ashraf
OBJECTIVE: The study examined resources needed by Infection Preventionists (IP) to address infection prevention and control (IPC) program gaps. DESIGN: A 49-question survey. SETTING: Licensed Critical Access Hospitals (CAHs) in Federal Emergency Management Area (FEMA) Region VII. PARTICIPANTS: IP at licensed CAHs. METHODS: The survey conducted between December 2020 and January 2021 consisted of questions focusing on four categories including IPC program infrastructure, competency-based training, audit and feedback, and identification of high-risk pathogens/serious communicable diseases (HRP/SCD)...
2024: Antimicrob Steward Healthc Epidemiol
https://read.qxmd.com/read/38492760/vascular-access-device-type-for-systemic-anti-cancer-therapies-in-cancer-patients-a-scoping-review
#10
REVIEW
C Duggan, O Hernon, R Dunne, V McInerney, S R Walsh, A Lowery, M McCarthy, P J Carr
BACKGROUND: Patients with cancer can expect to receive numerous invasive vascular access procedures for intravenous therapy and clinical diagnostics. Due to the increased incidence and prevalence of cancer globally there will be significantly more people who require first-line intravenous chemotherapy over the next ten years. METHODS: Our objective was to determine the types of evidence that exist for the vascular access device (VAD) type for the delivery of systemic anti-cancer therapy (SACT) in cancer patients...
March 14, 2024: Critical Reviews in Oncology/hematology
https://read.qxmd.com/read/38487127/daptomycin-and-ceftaroline-combination-therapy-in-complicated-endovascular-infections-caused-by-methicillin-resistant-staphylococcus-epidermidis
#11
JOURNAL ARTICLE
Sílvia Policarpo, Raquel Duro, Nuno R Pereira, Lurdes Santos
Background In complicated endovascular infections by methicillin-resistant Staphylococcus aureus (MRSA) or Staphylococcus epidermidis (MRSE), when first-line therapy with vancomycin (VAN) or daptomycin (DAP) fails, combination therapy with ceftaroline (CFT) and DAP has been shown to be a useful approach as salvage therapy for persistent MRSA bacteremia. Objectives This study aimed to describe experience with daptomycin and ceftaroline combination therapy in MRSE-complicated endovascular infections. Methods A single-center retrospective review of consecutive patients with MRSE-complicated endovascular infections treated with ≥72 hours of DAP+CFT at any time during the course of treatment, from January 1, 2016 to December 31, 2020, at Centro Hospitalar Universitário São João (CHUSJ), Porto, Portugal, was conducted...
February 2024: Curēus
https://read.qxmd.com/read/38485556/adverse-events-associated-with-umbilical-vascular-catheters-in-the-neonatal-intensive-care-unit-a-retrospective-cohort-study
#12
JOURNAL ARTICLE
Kim Gibson, Amber Smith, Rebecca Sharp, Amanda Ullman, Scott Morris, Adrian Esterman
BACKGROUND: Umbilical catheters are commonly inserted in newborns in the neonatal intensive care unit (NICU) yet are associated with serious adverse events (AEs) such as malposition, migration, infection, thrombosis, hepatic complications, cardiac effusion, and cardiac tamponade. There is a need to determine the incidence and risk factors for AEs to inform safe practice. OBJECTIVES: The objective of this study was to determine the incidence and risk factors for AEs (all-cause and individual types) associated with umbilical venous catheters (UVCs) and umbilical arterial catheters (UACs) in the NICU...
March 13, 2024: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
https://read.qxmd.com/read/38483930/characterizing-patients-presenting-on-hospital-admission-with-central-line-associated-bloodstream-infections-a-multicenter-study
#13
JOURNAL ARTICLE
Opeyemi Oladapo-Shittu, Sara E Cosgrove, Clare Rock, Yea-Jen Hsu, Eili Klein, Anthony D Harris, Carlos Mejia Chew, Heather Saunders, Patrick R Ching, Avi Gadala, Stephanie Mayoryk, Lisa Pineles, Lisa Maragakis, Alejandra Salinas, Taylor Helsel, Sara C Keller
BACKGROUND: There are no systematic measures of central line-associated bloodstream infections (CLABSIs) in patients maintaining central venous catheters (CVCs) outside acute care hospitals. To improve understanding of the burden of CLABSIs outside acute care hospitals, we characterized patients with CLABSI present on hospital admission (POA). METHODS: Retrospective cross-sectional analysis of patients with CLABSI-POA in three health systems covering eleven hospitals across Maryland, Washington DC, and Missouri from November 2020 to October 2021...
March 14, 2024: Clinical Infectious Diseases
https://read.qxmd.com/read/38479922/a-case-report-of-lactobacillus-bacteremia-in-a-patient-on-chronic-parenteral-nutrition
#14
JOURNAL ARTICLE
Hannah W Fiske, Breton Roussel, Marion Winkler, Benjamin Hall
BACKGROUND AND AIMS: Short bowel syndrome is a malabsorption disorder typically caused by the physical loss of a portion of the intestine, whereafter the body is unable to adequately absorb nutrients, fluids, and electrolytes. Many patients with short bowel syndrome are reliant on home parenteral nutrition through a tunneled or peripherally inserted central catheter to ensure sufficient hydration and nutrition. Central venous catheters are a nidus for bacteria, and patients are at risk for infections associated with high levels of morbidity and mortality...
April 2024: Clinical Nutrition ESPEN
https://read.qxmd.com/read/38459444/is-central-venous-catheter-in-haemodialysis-still-the-main-factor-of-mortality-after-hospitalization
#15
JOURNAL ARTICLE
Erwin Campos, Miguel Angel Cuevas-Budhart, Renata Cedillo-Flores, Julián Candelario-López, Rigoberto Jiménez, Alberto Flores-Almonte, Alfonso Ramos-Sanchez, Jose C Divino Filho
BACKGROUND: Haemodialysis is the most frequently prescribed Renal Replacement Therapy modality worldwide. However, patients undergoing this therapy have an unpredictable evolution related to vascular access. OBJECTIVE: To determine the factors associated with the mortality and hospitalization rate in haemodialysis patients at a third-level care Centre in the Dominican Republic. METHODS: This was an observational and prospective study involving a cohort of 192 haemodialysis patients...
March 8, 2024: BMC Nephrology
https://read.qxmd.com/read/38457237/bacteremia-associated-with-non-tunneled-central-venous-catheters-in-children-undergoing-chronic-hemodialysis
#16
JOURNAL ARTICLE
Diana Di Pinto, Marta Adragna, Jorge Mamani, Laura Mendoza, Gabriel Maita, Silvia Rodríguez, Marcela Álvarez, Rudy Bustamante, Pablo D'Alessandro, Laura López
Introduction. Central venous catheter (CVC)-related infection is the main complication observed in patients undergoing hemodialysis with this type of venous access. Objective. To estimate the incidence of non-tunneled CVC-related bacteremia, analyze the frequency of causative agents, and explore associated risk factors in children undergoing hemodialysis. Population and methods. Retrospective study in children receiving hemodialysis via a non-tunneled CVC between June 1st, 2015 and June 30th, 2019. A logistic regression was carried out to assess risk factors that were predictors of CVC-related bacteremia...
March 14, 2024: Archivos Argentinos de Pediatría
https://read.qxmd.com/read/38455615/a-fatal-case-of-harlequin-ichthyosis-experience-from-low-resource-setting
#17
JOURNAL ARTICLE
Vella Vella, Mimi Maulida, Nanda Earlia, Arie Hidayati, Risna Handriani, Srie P Gondokaryono, Reiva F Dwiyana, Ezigbo E Doris, Aldilla Pradistha, Mikyal Bulqiah
Harlequin ichthyosis is a severe and fatal presentation of ichthyosis with an autosomal recessive inheritance. Infants with Harlequin ichthyosis have a high mortality rate, and a dismal prognosis; therefore the majority of neonates die shortly after birth from infection, heat loss, dehydration, electrolytic imbalances, or respiratory distress. The aim of this case report was to present a fatal case of Harlequin ichthyosis with no family history of any inherited skin disorder. A 3-day-old baby was presented to the emergency room with congenital abnormalities at birth, fissured hyperkeratotic skin, and thick yellow plates of scales...
December 2023: Narra J
https://read.qxmd.com/read/38452780/safety-and-efficacy-of-phage-application-in-bacterial-decolonisation-a-systematic-review
#18
REVIEW
Qingqing Fang, Xin Yin, Yanling He, Yan Feng, Linwan Zhang, Huan Luo, Geng Yin, Alan McNally, Zhiyong Zong
Colonisation by bacterial pathogens typically precedes invasive infection and seeds transmission. Thus, effective decolonisation strategies are urgently needed. The literature reports attempts to use phages for decolonisation. To assess the in-vivo efficacy and safety of phages for bacterial decolonisation, we performed a systematic review by identifying relevant studies to assess the in-vivo efficacy and safety of phages for bacterial decolonisation. We searched PubMed, Embase (Ovid), MEDLINE (Ovid), Web of Science, and the Cochrane Library to identify relevant articles published between Jan 1, 1990, and May 12, 2023, without language restrictions...
March 4, 2024: The Lancet. Microbe
https://read.qxmd.com/read/38451571/bacterial-coinfections-in-covid-19-hospitalized-patients
#19
JOURNAL ARTICLE
Ingrid Stéfanie Sarmento Debaco, Helena Moreira Kluck, Rômulo Marx, Paulo Ricardo Mottin da Rosa, Cassiano Teixeira
OBJECTIVE: The aim of this study was to assess the rate of bacterial infections in COVID-19-hospitalized patients and to analyze the most prevalent germs, sources, risk factors, and its impact on in-hospital mortality. METHODS: This observational retrospective study was conducted on 672 patients hospitalized between April and August 2020 in Nossa Senhora da Conceição Hospital, a public hospital located in Porto Alegre, Brazil. The inclusion criterion was adult patients hospitalized with confirmed COVID-19...
2024: Revista da Associação Médica Brasileira
https://read.qxmd.com/read/38451357/surgical-outcomes-of-very-early-onset-ulcerative-colitis-retrospective-comparative-study-with-older-pediatric-patients
#20
JOURNAL ARTICLE
Takashi Fumita, Keita Terui, Ryohei Shibata, Ayako Takenouchi, Shugo Komatsu, Satoru Oita, Hiroko Yoshizawa, Yuichi Hirano, Yusaku Yoshino, Takeshi Saito, Tomoro Hishiki
PURPOSE: The study compares the surgical outcomes of very-early-onset ulcerative colitis (VEO-UC), which is a rare disease diagnosed in pediatric patients < 6 years, with those of older pediatric patients with ulcerative colitis (UC). METHODS: A retrospective observational study of 57 pediatric patients with UC was conducted at a single center. The study compared surgical complications and postoperative growth between the two groups. RESULTS: Out of the 57 patients, 6 had VEO-UC, and 5 of them underwent total colectomy...
March 7, 2024: Pediatric Surgery International
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