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https://www.readbyqxmd.com/read/28733871/a-mdr-transporter-contributes-to-the-different-extracellular-production-of-sesquiterpene-pyridine-alkaloids-between-adventitious-root-and-hairy-root-liquid-cultures-of-tripterygium-wilfordii-hook-f
#1
Guo-Peng Miao, Juan Han, Ji-Feng Zhang, Chuan-Shu Zhu, Xing Zhang
TwMDR1 transports sesquiterpene pyridine alkaloids, wilforine and wilforgine, into the hairy roots of T. wilfordii Hook.f. resulting in low secretion ratio of alkaloids. Hairy roots (HRs) exhibit high growth rate and biochemical and genetic stability. However, varying secondary metabolites in HR liquid cultures mainly remain in root tissues, and this condition may affect cell growth and cause inconvenience in downstream extraction. Studies pay less attention to adventitious root (AR) liquid cultures though release ratio of some metabolites in AR liquid cultures is significantly higher than that of HR...
July 21, 2017: Plant Molecular Biology
https://www.readbyqxmd.com/read/28733262/cost-effectiveness-of-high-performance-biomarker-tests-vs-fecal-immunochemical-test-for-non-invasive-colorectal-cancer-screening
#2
Iris Lansdorp-Vogelaar, S Lucas Goede, Linda J W Bosch, Veerle Melotte, Beatriz Carvalho, Manon van Engeland, Gerrit A Meijer, Harry J de Koning, Marjolein van Ballegooijen
BACKGROUND: Biomarker assays could increase the accuracy of non-invasive detection of colorectal cancer (CRC); fecal immunochemical tests (FITs) are estimated to miss 27%-47% of CRCs and 70%-80% of advanced adenomas per round of screening. We investigated the conditions under which biomarker screens would be cost-effective compared to FIT screens of average risk individuals. METHODS: We used the MISCAN-colon microsimulation model to estimate the effects of various CRC screening test characteristics on life years gained (LYG) and costsBiomarker assays could increase the accuracy of non-invasive detection of colorectal cancer (CRC); fecal immunochemical tests (FITs) are estimated to miss 27%-47% of CRCs and 70%-80% of advanced adenomas per round of screening...
July 18, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28731222/bio-nano-interface-and-environment-a-critical-review
#3
Gerardo Pulido-Reyes, Francisco Leganes, Francisca Fernández-Piñas, Roberto Rosal
The Bio-Nano interface is the boundary where the Engineered NanoMaterials (ENM) meet the biological system, exerting the biological function for what they have been designed or inducing adverse effects to other cells or organisms when they reach non-target scenarios, i.e: the natural environment. Research has been performed to determine the fate, transport, and toxic properties of ENM, but much of it focused on pristine or "as manufactured" ENM or where modifications of the materials were not assessed. This article reviews the most recent progresses regarding the Bio-Nano interface and the transformations that ENM suffer in the environment, paying special attention to the adsorption of environmental biomolecules on the surface of ENM...
July 21, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28730746/management-and-prevalence-of-long-term-conditions-in-primary-health-care-for-adults-with-intellectual-disabilities-compared-with-the-general-population-a-population-based-cohort-study
#4
Sally-Ann Cooper, Laura Hughes-McCormack, Nicola Greenlaw, Alex McConnachie, Linda Allan, Marion Baltzer, Laura McArthur, Angela Henderson, Craig Melville, Paula McSkimming, Jill Morrison
BACKGROUND: In the UK, general practitioners/family physicians receive pay for performance on management of long-term conditions, according to best-practice indicators. METHOD: Management of long-term conditions was compared between 721 adults with intellectual disabilities and the general population (n = 764,672). Prevalence of long-term conditions was determined, and associated factors were investigated via logistic regression analyses. RESULTS: Adults with intellectual disabilities received significantly poorer management of all long-term conditions on 38/57 (66...
July 20, 2017: Journal of Applied Research in Intellectual Disabilities: JARID
https://www.readbyqxmd.com/read/28730080/old-canalicular-laceration-repair-a-retrospective-study-of-the-curative-effects-and-prognostic-factors
#5
Fang Bai, Hai Tao, Yan Zhang, Peng Wang, Cui Han, Yi-Fei Huang, Ye Tao
AIM: To investigate the epidemiology and surgical outcomes of old canalicular laceration and analyze the variables impacting on the prognosis of reparation. METHODS: A retrospective review of all old canalicular laceration repairs from Jan. 1, 2008 to Dec. 30, 2015 was performed. Analyzed data included demographics, mechanisms of injury, the time from injury to repair, causes for delayed repair, old associated injuries, the types of surgery, and the effects of repair using canaliculus anastomosis combined with bicanalicular stent intubation...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28727897/the-course-of-fear-of-cancer-recurrence-different-patterns-by-age-in-breast-cancer-survivors
#6
Daniëlle E J Starreveld, Sabine E Markovitz, Gerard van Breukelen, Madelon L Peters
OBJECTIVE: To examine the time course and predictors of fear of cancer recurrence (FCR) in breast cancer survivors over a period of 18 months after initial surgery. METHODS: Breast cancer patients (n = 267) were followed until 18 months after primary breast surgery. Shortly after surgery, participants completed the Life Orientation Test-Revised (LOT-R) to measure optimism and the Concerns about Recurrence Scale (CARS) to measure FCR. Mixed regression analysis was performed with age, optimism, marital status, education, type of surgery, with or without lymphectomy, chemotherapy, hormonal therapy, or radiotherapy, time since surgery and all interactions with time as predictors of FCR...
July 20, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28727022/triennial-growth-and-development-symposium-genetics-and-breeding-for-intramuscular-fat-and-oleic-acid-content-in-pigs
#7
J Estany, R Ros-Freixedes, M Tor, R N Pena
The intramuscular fat (IMF) and oleic acid (OL) content have been favorably related to pork quality and human health. This influences the purchasing behavior of consumers and, therefore, also shifts the attention of breeding companies toward whether these traits are included into the breeding goal of the lines producing for high-valued markets. Because IMF and OL are unfavorably associated with lean content, a key economic trait, the real challenge for the industry is not simply to increase IMF and OL, but rather to come up with the right trade-off between them and lean content...
May 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28725118/share-capitalism-and-worker-wellbeing
#8
Alex Bryson, Andrew E Clark, Richard B Freeman, Colin P Green
We show that worker wellbeing is determined not only by the amount of compensation workers receive but also by how compensation is determined. While previous theoretical and empirical work has often been preoccupied with individual performance-related pay, we find that the receipt of a range of group-performance schemes (profit shares, group bonuses and share ownership) is associated with higher job satisfaction. This holds conditional on wage levels, so that pay methods are associated with greater job satisfaction in addition to that coming from higher wages...
October 2016: Labour Economics
https://www.readbyqxmd.com/read/28724403/the-association-between-attention-deficit-hyperactivity-disorder-and-internet-addiction-a-systematic-review-and-meta-analysis
#9
Bing-Qian Wang, Nan-Qi Yao, Xiang Zhou, Jian Liu, Zheng-Tao Lv
BACKGROUND: This study aimed to analyze the association between Attention Deficit/Hyperactivity Disorder (ADHD) and Internet addiction (IA). METHODS: A systematic literature search was performed in four online databases in total including CENTRAL, EMBASE, PubMed and PsychINFO. Observational studies (case-control, cross-sectional and cohort studies) measuring the correlation between IA and ADHD were screened for eligibility. Two independent reviewers screened each article according to the predetermined inclusion criteria...
July 19, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28719769/prevalence-of-smoking-and-associated-factors-evidence-from-the-chililab-demographic-surveillance-system-in-vietnam
#10
Le Thi Thanh Huong, Tran Khanh Long, Phung Xuan Son, Tran Thi Tuyet-Hanh
This study analyzed secondary data from Chi Linh Health and Demographic Surveillance System (CHILILAB) database to identify smoking prevalence and associated demographic factors. Data were extracted from the database of the CHILILAB 2016, which included information on individual smoking behaviors, as well as individual and household demographic data. Descriptive and binary logistic regression analyses were performed with significance level of 0.05. The smoking prevalences were 34.7%, 0.9%, and 16.1% for men, women, and both genders, respectively...
July 2017: Asia-Pacific Journal of Public Health
https://www.readbyqxmd.com/read/28718037/cost-effectiveness-of-surveillance-for-distant-recurrence-in-extremity-soft-tissue-sarcoma
#11
Trevor J Royce, Rinaa S Punglia, Aileen B Chen, Sagar A Patel, Katherine A Thornton, Chandrajit P Raut, Elizabeth H Baldini
BACKGROUND: Optimal distant recurrence (DR) surveillance strategies for extremity soft tissue sarcoma (STS) are unknown. We performed a cost-effectiveness analysis of different imaging modalities performed at guideline-specified intervals. METHODS: We developed a Markov model simulating lifetime outcomes for 54-year-old patients after definitive treatment for American Joint Committee on Cancer stage II-III extremity STS using four surveillance strategies: watchful waiting (WW), chest X-ray (CXR), chest computed tomography (CCT), and positron emission tomography-computed tomography (PET/CT)...
July 17, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28714428/are-newly-added-and-lost-confidants-in-later-life-related-to-subsequent-mental-health
#12
Ella Schwartz, Howard Litwin
BACKGROUND: This study examined internal changes in the personal social networks of older people and the relationship between these changes and mental health over time. It focused on two key aspects: emotional closeness and contact frequency with lost and newly added confidants. METHODS: The study was based on data from the fourth (2011) and sixth (2015) waves of the Survey of Health, Ageing and Retirement in Europe (SHARE). The study sample consisted of respondents aged 65 years and older who participated in both waves (n = 14,101)...
July 17, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28713309/associations-among-different-internet-access-time-gender-and-cyberbullying-behaviors-in-taiwan-s-adolescents
#13
Cheng-Min Chao, Tai-Kuei Yu
With the increasing convenience of social networking sites and their interconnectedness with human interaction, verbal and image bullying have turned digital, making cyberbullying a new form of bullying attracting the attention of researchers, social workers, and schools. This study focuses on the status quo of attitude toward cyberbullying and cyberbullying behavior, explores associations of attitude toward behavior on cyberbullying behavior in gender and different internet access times. In a cross-sectional survey, adolescents were surveyed through self-report questionnaires, 13,864 respondents were received among 150 high schools in Taiwan...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28708749/effectiveness-of-pay-for-performance-for-chronic-kidney-disease-patients-on-hemodialysis-a-systematic-review-protocol
#14
Jo Ann A Otts, Patricia F Pearce, Cynthia A Langford
The objective of this review is to assess the evidence on the effectiveness of implementation of a pay-for-performance program on clinical outcomes in the adult chronic kidney disease (CKD) patient receiving hemodialysis.The review question is: What is the effectiveness of implementation of a pay-for-performance program on clinical outcomes in the adult CKD patient receiving hemodialysis, as compared to the period immediately before implementation of the program?More specifically, the objectives are to identify...
July 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28706743/when-is-the-optimal-timing-of-surgical-intervention-for-severe-functional-tricuspid-regurgitation
#15
Nobuhiro Nakanishi, Masanobu Ishii, Koichi Kaikita, Ken Okamoto, Yasuhiro Izumiya, Eiichiro Yamamoto, Seiji Takashio, Seiji Hokimoto, Toshihiro Fukui, Kenichi Tsujita
Functional tricuspid regurgitation (TR) is a serious pathology to be noted for severe right heart failure (HF) and poor prognosis; however, the conventional assessment of TR has some limitations and the optimal timing of surgical intervention remains unclear. A 79-year-old Japanese female was admitted to our hospital to undergo cardiac surgery, because edema gradually got worse despite the increase in diuretics. She had a history of atrial fibrillation (AF) and chronic HF due to severe TR and had been treated with a furosemide for leg edema 4 years ago...
2017: Case Reports in Cardiology
https://www.readbyqxmd.com/read/28705111/use-of-portable-ladders-field-observations-and-self-reported-safety-performance-in-the-cable-tv-industry
#16
Wen-Ruey Chang, Yueng-Hsiang Huang, Christopher Brunette, Jin Lee
Portable ladders incidents remain a major cause of falls from heights. This study reported field observations of environments, work conditions and safety behaviour involving portable ladders and their correlations with self-reported safety performance. Seventy-five professional installers of a company in the cable and other pay TV industry were observed for 320 ladder usages at their worksites. The participants also filled out a questionnaire to measure self-reported safety performance. Proper setup on slippery surfaces, correct method for ladder inclination setup and ladder secured at the bottom had the lowest compliance with best practices and training guidelines...
July 14, 2017: Ergonomics
https://www.readbyqxmd.com/read/28703323/professional-oral-healthcare-for-preventing-nursing-home-acquired-pneumonia-a-cost-effectiveness-and-value-of-information-analysis
#17
Falk Schwendicke, Michael Stolpe, Frauke Müller
AIM: Professional oral healthcare (POHC) prevents nursing-home-acquired pneumonia (NHAP) and its related mortality. We assessed the cost-effectiveness of POHC versus no POHC (nPOHC) and the monetary value of eliminating uncertainty by future research. METHODS: German public-private-payer-perspective was adopted. A Markov-model was used, following Long-Term-Care residents from admission to death. Cost-effectiveness was estimated as Euro/disability-adjusted-life-year (DALY) using Monte-Carlo microsimulations...
July 13, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28701986/controlling-the-anchoring-effect-through-transcranial-direct-current-stimulation-tdcs-to-the-right-dorsolateral-prefrontal-cortex
#18
Jianbiao Li, Xile Yin, Dahui Li, Xiaoli Liu, Guangrong Wang, Liang Qu
Selective accessibility mechanisms indicate that anchoring effects are results of selective retrieval of working memory. Neuroimaging studies have revealed that the right dorsolateral prefrontal cortex (DLPFC) is closely related to memory retrieval and performance. However, no research has investigated the effect of changing the cortical excitability in right DLPFC on anchoring effects. Transcranial direct current stimulation (tDCS) can modulate the excitability of the human cerebral cortex, while anodal and cathodal tDCS are postulated to increase or decrease cortical activity, respectively...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28701889/education-for-community-based-family-medicine-a-social-need-in-the-real-world
#19
REVIEW
Shin-Ichi Taniguchi, Daeho Park, Kazuoki Inoue, Toshihiro Hamada
One of the most critical social problems in Japan is the remarkable increase in the aging population. Elderly patients with a variety of complications and issues other than biomedical problems such as dementia and life support with nursing care have been also increasing. Ever since the Japanese economy started to decline after the economic bubble burst of 1991 and the Lehman Brothers bankruptcy in 2008, how we can resolve health problems of the elderly at a lower cost has become one of our most challenging social issues...
June 2017: Yonago Acta Medica
https://www.readbyqxmd.com/read/28699130/cost-effectiveness-of-risk-reducing-mastectomy-versus-surveillance-in-brca-mutation-carriers-with-a-history-of-ovarian-cancer
#20
Charlotte Gamble, Laura J Havrilesky, Evan R Myers, Junzo P Chino, Scott Hollenbeck, Jennifer K Plichta, P Kelly Marcom, E Shelley Hwang, Noah D Kauff, Rachel A Greenup
BACKGROUND: The appropriate management of breast cancer risk in BRCA mutation carriers following ovarian cancer diagnosis remains unclear. We sought to determine the survival benefit and cost effectiveness of risk-reducing mastectomy (RRM) among women with BRCA1/2 mutations following stage II-IV ovarian cancer. DESIGN: We constructed a decision model from a third-party payer perspective to compare annual screening with magnetic resonance imaging (MRI) and mammography to annual screening followed by RRM with reconstruction following ovarian cancer diagnosis...
July 11, 2017: Annals of Surgical Oncology
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