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https://www.readbyqxmd.com/read/29453078/diterpenoids-from-the-roots-of-euphorbia-ebracteolata-and-their-anti-tuberculosis-effects
#1
Zhenlong Yu, Yunlong Wei, Xiangge Tian, Qiulong Yan, Qingsong Yan, Xiaokui Huo, Chao Wang, Chengpeng Sun, Baojing Zhang, Xiaochi Ma
Euphorbia ebracteolata was a natural medicine for the treatment of tuberculosis. The present work has performed the investigation of bioactive chemical substances from the roots of E. ebracteolata. Using various chromatographic techniques, 15 compounds were obtained from the roots of E. ebracteolata. On the basis of widely spectroscopic data analyses, the isolated compounds were determined to be diterpenoids, including rosane derivatives (1-12), isopimarane (13), abietane (14), and lathyrane (15), among which compounds 1-4, and 9 were undescribed previously...
February 12, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29451916/awareness-and-attitude-of-the-public-toward-personalized-medicine-in-korea
#2
Iyn-Hyang Lee, Hye-Young Kang, Hae Sun Suh, Sukhyang Lee, Eun Sil Oh, Hotcherl Jeong
OBJECTIVES: As personalized medicine (PM) is expected to greatly improve health outcomes, efforts have recently been made for its clinical implementation in Korea. We aimed to evaluate public awareness and attitude regarding PM. METHODS: We performed a self-administered questionnaire survey to 703 adults, who participated in the survey on a voluntary basis. The primary outcome measures included public knowledge, attitude, and acceptance of PM. We conducted multinomial multivariate logistic analysis for outcome variables with three response categories and performed multivariate logistic regression analyses for dichotomous outcome variables...
2018: PloS One
https://www.readbyqxmd.com/read/29450830/personalized-medicine-and-pay-for-performance-should-pharmaceutical-firms-be-fully-penalized-when-treatment-fails
#3
Fernando Antoñanzas, Roberto Rodríguez-Ibeas, Carmelo A Juárez-Castelló
In this article, we model the behavior of a pharmaceutical firm that has marketing authorization for a new therapy believed to be a candidate for personalized use in a subset of patients, but that lacks information as to why a response is seen only in some patients. We characterize the optimal outcome-based reimbursement policy a health authority should follow to encourage the pharmaceutical firm to undertake research and development activities to generate the information needed to effectively stratify patients...
February 15, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29448856/study-of-target-and-non-target-interplay-in-spatial-attention-task
#4
Sweeti, Deepak Joshi, B K Panigrahi, Sneh Anand, Jayasree Santhosh
Selective visual attention is the ability to selectively pay attention to the targets while inhibiting the distractors. This paper aims to study the targets and non-targets interplay in spatial attention task while subject attends to the target object present in one visual hemifield and ignores the distractor present in another visual hemifield. This paper performs the averaged evoked response potential (ERP) analysis and time-frequency analysis. ERP analysis agrees to the left hemisphere superiority over late potentials for the targets present in right visual hemifield...
February 15, 2018: Journal of Medical Engineering & Technology
https://www.readbyqxmd.com/read/29444671/tailoring-an-educational-program-on-the-ahrq-patient-safety-indicators-to-meet-stakeholder-needs-lessons-learned-in-the-va
#5
Marlena H Shin, Peter E Rivard, Michael Shwartz, Ann Borzecki, Enzo Yaksic, Kelly Stolzmann, Lisa Zubkoff, Amy K Rosen
BACKGROUND: Given that patient safety measures are increasingly used for public reporting and pay-for performance, it is important for stakeholders to understand how to use these measures for improvement. The Agency for Healthcare Research and Quality (AHRQ) Patient Safety Indicators (PSIs) are one particularly visible set of measures that are now used primarily for public reporting and pay-for-performance among both private sector and Veterans Health Administration (VA) hospitals. This trend generates a strong need for stakeholders to understand how to interpret and use the PSIs for quality improvement (QI)...
February 14, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29442280/patient-satisfaction-with-a-chronic-kidney-disease-risk-assessment-service-in-community-pharmacies
#6
Pankti A Gheewala, Gregory M Peterson, Syed Tabish R Zaidi, Matthew D Jose, Ronald L Castelino
BACKGROUND: Patient satisfaction is an important determinant of the feasibility and sustainability of community pharmacy screening services. However, few studies have evaluated this, with no such study performed for a chronic kidney disease risk assessment service. OBJECTIVE: The aim was to determine patient satisfaction with a chronic kidney disease risk assessment service performed in community pharmacies. SETTING: Community pharmacies in the state of Tasmania, Australia...
February 13, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29441505/eliciting-the-monetary-value-of-a-quality-adjusted-life-year-in-a-greek-outpatient-department-in-times-of-economic-austerity
#7
A Mavrodi, V Aletras, A Spanou, D Niakas
BACKGROUND AND OBJECTIVE: Contingent valuation is widely used to determine individuals' willingness to pay (WTP) for a health gain. Our study aimed to elicit an empirical estimate of the monetary value of a quality-adjusted life year (QALY) in a Greek outpatient setting in times of economic austerity and assess the impact of patients' characteristics on their valuations. METHODS: We used a questionnaire as a survey tool to determine the maximum WTP for a health gain of a hypothetical therapy and to evaluate patients' health-related quality of life (EuroQoL-5D-3L) and demographic and socioeconomic characteristics...
December 2017: PharmacoEconomics Open
https://www.readbyqxmd.com/read/29439582/diversity-of-hiv-1-in-aquitaine-south-western-france-2012-2016
#8
Camille Tumiotto, Pantxika Bellecave, Patricia Recordon-Pinson, Alexi Groppi, Macha Nikolski, Herve J Fleury
We have estimated the prevalence of the different viral subtypes between January 2012 and December 2016 in HIV-1-infected patients of the Aquitaine region (south-west part of France) who had a routine HIV-1 genotype resistance testing (GRT) centralized at the Bordeaux University Hospital. GRT was performed on viral RNA (1784 samples) before treatment initiation or at failure whereas proviral DNA was used as template (1420 samples) in the event of a treatment switch in patients with viral load below 50 copies/mL...
February 14, 2018: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29438112/executive-functioning-and-daily-living-of-individuals-with-chronic-stroke-measurement-and-implications
#9
Lena Lipskaya-Velikovsky, Gabi Zeilig, Harold Weingarden, Clara Rozental-Iluz, Debbie Rand
Deficits in executive functioning (EF) are often still present at the chronic stage after stroke, which may negatively impact independent living. The objectives of this study were (a) to characterize the EF and independence in daily living of community-dwelling individuals with chronic stroke by using pen-and-paper and performance-based EF assessments, (b) to explore correlations between scores detected by different EF assessments and (c) to assess the correlations between EF and independence in basic activities of daily living (BADL) and instrumental activities of daily living (IADL)...
February 12, 2018: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/29429444/safety-and-affordability-of-an-elective-saturday-list-at-pietersburg-hospital-limpopo-south-africa
#10
M M Z U Bhuiyan, R Mavhungu
BACKGROUND: The backlog of patients waiting for operations continues to be a problem in many public hospitals in South Africa (SA), with elective surgery procedures being postponed for up to 2 years. OBJECTIVE: To determine the rate of death in hospital or out of hospital within 30 days of an elective procedure performed on a Saturday, and to determine the cost incurred by paying staff members who perform these operations. METHOD: A prospective, observational descriptive cohort study of all patients undergoing inpatient general surgery operations during weekdays and weekends between 1 September 2015 and 31 August 2016 (1 year) at Pietersburg Hospital (PBH), Limpopo, SA...
February 1, 2018: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/29428480/patient-positioning-for-robot-assisted-laparoscopic-benign-gynecologic-surgery-a-review
#11
REVIEW
Ozguc Takmaz, Mehmet Resit Asoglu, Mete Gungor
Robotic surgical platforms are now in widespread use in the practice of gynecology all over the world. The introduction of robotic surgery has required some modifications of patient positioning when compared to standard laparoscopic surgery. Optimal patient positioning is likely to be the most essential step of robotic surgery as it provides the technical feasibility to have adequate access to the pelvic structures for performing the surgery. It is prudent to pay attention to preventing patient shifting in Trendelenburg position because of tendency of sliding down toward the direction of the head...
February 6, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29427238/opinion-paper-scientific-philosophical-and-legal-consideration-of-doping-in-sports
#12
REVIEW
Massimo Negro, Natale Marzullo, Francesca Caso, Luca Calanni, Giuseppe D'Antona
The term doping is generally used to indicate practices based on the use of performance-enhancing drugs (PEDs) or the abuse of medical therapies. Mostly analysed by doctors and officials, doping nevertheless also requires a philosophical consideration to avoid being simplistically portrayed as an isolated practice. To do this, we need to pay attention to the contradictions and paradoxes in the modern approach to doping in sport. In this context, doping is not only relevant to the health of an individual involved in the violation of World Anti-Doping Agency (WADA) criteria, but it actually represents a double-edged phenomenon containing ethical and legal points of view...
February 9, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29426384/development-of-internet-based-tasks-for-the-executive-function-performance-test
#13
Debbie Rand, Keren Lee Ben-Haim, Rachel Malka, Sigal Portnoy
OBJECTIVE: The Executive Function Performance Test (EFPT) is a reliable and valid performance-based tool to assess executive functions (EFs). This study's objective was to develop and verify two Internet-based tasks for the EFPT. METHOD: A cross-sectional study assessed the alternate-form reliability of the Internet-based bill-paying and telephone-use tasks in healthy adults and people with subacute stroke (Study 1). It also sought to establish the tasks' criterion reliability for assessing EF deficits by correlating performance with that on the Trail Making Test in five groups: healthy young adults, healthy older adults, people with subacute stroke, people with chronic stroke, and young adults with attention deficit hyperactivity disorder (Study 2)...
March 2018: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
https://www.readbyqxmd.com/read/29425310/cost-effectiveness-analysis-of-a-military-hearing-conservation-program
#14
Seth L Garcia, Kenneth J Smith, Catherine Palmer
Introduction: Occupational noise threatens U.S. worker health and safety and commands a significant financial burden on state and federal government worker compensation programs. Previous studies suggest that hearing conservation programs have contributed to reduced occupational hearing loss for noise-exposed workers. Many military personnel are overexposed to noise and are provided hearing conservation services. Select military branches require all active duty personnel to follow hearing conservation program guidelines, regardless of individual noise exposure...
February 7, 2018: Military Medicine
https://www.readbyqxmd.com/read/29421461/assessing-the-feasibility-of-community-health-insurance-in-uganda-a-mixed-methods-exploratory-analysis
#15
M Biggeri, M Nannini, G Putoto
Community health insurance (CHI) aims to provide financial protection and facilitate health care access among poor rural populations. Given common operational challenges that hamper the full development of the scheme, there is need to undertake systematic feasibility studies. These are scarce in the literature and usually they do not provide a comprehensive analysis of the local context. The present research intends to adopt a mixed-methods approach to assess ex-ante the feasibility of CHI. In particular, eight preconditions are proposed to inform the viability of introducing the micro insurance...
January 31, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29420427/the-price-we-pay-for-radical-curative-pelvic-exenterations-prevalence-and-management-of-pain
#16
Jessica Shao-Yeung Lim, Cherry E Koh, Hannah Liu, Michael J Solomon, Charlotte S H Johnstone
BACKGROUND: Pelvic exenterations are extensive surgical procedures for locally advanced or recurrent malignancies of the pelvis. However, this is often at the cost of significant morbidity due to perioperative pain, which has been poorly studied. OBJECTIVE: This study aims to review perioperative pain management in patients undergoing pelvic exenteration. DESIGN: This is a retrospective review of patients undergoing pelvic exenteration between January 2013 and December 2014...
March 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29409528/approaches-towards-improving-the-quality-of-maternal-and-newborn-health-services-in-south-asia-challenges-and-opportunities-for-healthcare-systems
#17
REVIEW
Naeem Uddin Mian, Muhammad Adeel Alvi, Mariam Zahid Malik, Sarosh Iqbal, Rubeena Zakar, Muhammad Zakria Zakar, Shehzad Hussain Awan, Faryal Shahid, Muhammad Ashraf Chaudhry, Florian Fischer
BACKGROUND: South Asia is experiencing a dismal state of maternal and newborn health (MNH) as the region has been falling behind in reducing the levels of maternal and neonatal mortality. Most of the efforts are focused on enhancing coverage of MNH services; however, quality remains a serious concern if the region is to achieve expected outcomes in terms of standardised MNH services within healthcare delivery systems. This research consists of a review of South Asian quality improvement (QI) approaches/interventions, specifically implemented for MNH improvement...
February 6, 2018: Globalization and Health
https://www.readbyqxmd.com/read/29409205/clinical-characteristics-and-surgical-experience-of-type-iii-wagstaffe-fractures-pay-attention-to-concomitant-chondral-injury-of-the-talus
#18
Ming Zhang, Yun-Feng Chen, Lei Wang, Fan Li, Hai-Feng Wei, Zhong-Min Shi
BACKGROUND: The purpose of this study was to investigate clinical characteristics and surgical management of Type III Wagstaffe fracture. METHODS: From August 2012 to July 2015, 13 patients with Type III Wagstaffe fractures were surgically treated. During operation, the cartilage of joint surface was explored. Wagstaffe fragment was fixed with cannulated screw or suture, Chaput fragment was fixed with cannulated screw or plate, and Cotton test was performed to evaluate the stability of syndesmosis during the operation...
April 27, 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29406837/optimization-of-medication-use-at-accountable-care-organizations
#19
Chrisanne Wilks, Erik Krisle, Kimberly Westrich, Kristina Lunner, David Muhlestein, Robert Dubois
BACKGROUND: Optimized medication use involves the effective use of medications for better outcomes, improved patient experience, and lower costs. Few studies systematically gather data on the actions accountable care organizations (ACOs) have taken to optimize medication use. OBJECTIVES: To (a) assess how ACOs optimize medication use; (b) establish an association between efforts to optimize medication use and achievement on financial and quality metrics; (c) identify organizational factors that correlate with optimized medication use; and (d) identify barriers to optimized medication use...
May 30, 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29403570/prospective-bundled-payments-in-a-changing-environment-the-experience-of-a-self-funded-state-sponsored-plan
#20
Frank H Lawler, Frank R Wilson, G Keith Smith, Lynn V Mitchell
Background: Healthcare reimbursement, which has traditionally been based on the quantity of services delivered, is currently moving toward value-based reimbursement-a system that addresses the quantity, quality, and cost of services. One such arrangement has been the evolution of bundled payments for a specific procedure or for an episode of care, paid prospectively or through post-hoc reconciliation. Objective: To evaluate the impact of instituting bundled payments that incorporate facility charges, physician fees, and all ancillary charges by the State of Oklahoma HealthChoice public employee insurance plan...
December 2017: American Health & Drug Benefits
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