keyword
https://read.qxmd.com/read/38145348/multiplexed-surface-electrode-arrays-based-on-metal-oxide-thin-film-electronics-for-high-resolution-cortical-mapping
#21
JOURNAL ARTICLE
Horacio Londoño-Ramírez, Xiaohua Huang, Jordi Cools, Anna Chrzanowska, Clément Brunner, Marco Ballini, Luis Hoffman, Soeren Steudel, Cédric Rolin, Carolina Mora Lopez, Jan Genoe, Sebastian Haesler
Electrode grids are used in neuroscience research and clinical practice to record electrical activity from the surface of the brain. However, existing passive electrocorticography (ECoG) technologies are unable to offer both high spatial resolution and wide cortical coverage, while ensuring a compact acquisition system. The electrode count and density are restricted by the fact that each electrode must be individually wired. This work presents an active micro-electrocorticography (µECoG) implant that tackles this limitation by incorporating metal oxide thin-film transistors (TFTs) into a flexible electrode array, allowing to address multiple electrodes through a single shared readout line...
December 25, 2023: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38128811/menthol-dural-application-alters-meningeal-arteries-tone-and-enhances-excitability-of-trigeminocervical-neurons-in-rats
#22
JOURNAL ARTICLE
Alexey Y Sokolov, Miran Mengal, Regina Berkovich
Headaches, including migraines, can have a causal relationship to exposure to cold, and this relationship may be both positive and negative, as cold can both provoke and alleviate cephalgia. The role of thermoreceptors responsible for transduction of low temperatures belongs to the transient receptor potential cation channel subfamily melastatin member 8 (TRPM8). These channels mediate normal cooling sensation and have a role in both cold pain and cooling-mediated analgesia; they are seen as a potential target for principally new anti-migraine pharmaceuticals...
December 20, 2023: Brain Research
https://read.qxmd.com/read/38111401/from-heat-stroke-to-multi-organ-failure-a-survivor-s-case-report
#23
Hanna Elbashir, Leena Saeed, Doaa Sabir, Marwa Morgom, Yara Abuazab, Tasneem Madebo, Alhady A Yusof
A heat stroke (HS) is a medical emergency that can occur when the body is unable to cool itself down after overexertion in a hot condition. It is characterized by a high body temperature (usually greater than 40.5 degrees Celsius or 104.9 degrees Fahrenheit) and altered mental status. HS can cause a wide range of physiological changes in the body, including damage to the brain, heart, liver, kidneys, and muscles. In the case report presented, the patient was a 40-year-old man who developed severe HS...
November 2023: Curēus
https://read.qxmd.com/read/38105803/targeted-temperature-management-and-p-bt-o-2-in-traumatic-brain-injury
#24
JOURNAL ARTICLE
Nika Cujkevic-Plecko, A Rodriguez, T Anderson, J Rhodes
INTRODUCTION: Targeted Temperature Management (TTM) to normothermia is widely used in traumatic brain injury (TBI). We investigated the effects to of TTM to normothermia patients with TBI (GCS≤12) monitored with multimodality monitoring, to better understand the physiological consequences of this intervention. RESEARCH QUESTION: In TBI patients cooled to normothermia and in which brain oxygenation deteriorates, are there changes in physiological parameters which are pertinent to brain oxygenation? MATERIAL AND METHOD: 102 TBI patients with continuous recordings of intracranial pressure (ICP) and brain oxygen tension (Pbt O2 ) were studied retrospectively...
2023: Brain Spine
https://read.qxmd.com/read/38043646/eeg-synchronized-left-prefrontal-transcranial-magnetic-stimulation-tms-for-treatment-resistant-depression-is-feasible-and-produces-an-entrainment-dependent-clinical-response-a-randomized-controlled-double-blind-clinical-trial
#25
JOURNAL ARTICLE
Mark S George, Sarah Huffman, Jayce Doose, Xiaoxiao Sun, Morgan Dancy, Josef Faller, Xingbao Li, Han Yuan, Robin I Goldman, Paul Sajda, Truman R Brown
BACKGROUND: Synchronizing a TMS pulse with a person's underlying EEG rhythm can modify the brain's response. It is unclear if synchronizing rTMS trains might boost the antidepressant effect of TMS. In this first-in-human trial, we demonstrated that a single TMS pulse over the prefrontal cortex produces larger effects in the anterior cingulate depending on when it is fired relative to the individual's EEG alpha phase. OBJECTIVE/HYPOTHESES: We had three hypotheses...
December 2, 2023: Brain Stimulation
https://read.qxmd.com/read/38026455/thermal-grill-illusion-in-post-stroke-patients-analysis-of-clinical-features-and-lesion-areas
#26
JOURNAL ARTICLE
Soichiro Matsuda, Yuki Igawa, Hidekazu Uchisawa, Shinya Iki, Michihiro Osumi
PURPOSE: In the thermal grill illusion, participants experience a feeling similar to burning pain. The illusion is induced by simultaneously touching warm and cool stimuli in alternating positions. In post-stroke pain, central sensitization is caused by a variety of factors, including damage to the spinothalamic tract and shoulder pain. Because the thermal grill illusion depends on central mechanisms, it has recently been suggested that it may be a useful indicator of central sensitization...
2023: Journal of Pain Research
https://read.qxmd.com/read/38020958/efficacy-and-safety-of-the-arctic-sun-device-for-hypoxic-ischemic-encephalopathy-in-adult-patients-following-cardiopulmonary-resuscitation-a-systematic-review-and-meta-analysis
#27
JOURNAL ARTICLE
Saurabh C Sharda, Mandip Singh Bhatia, Rohit R Jakhotia, Ashish Behera, Atul Saroch, Ashok Kumar Pannu, H Mohan Kumar
AIM: The principal objective of this study was to carry out a comprehensive and thorough analysis to compare the safety and effectiveness of the Arctic Sun, a servo-controlled surface cooling device, with conventional cooling techniques for providing therapeutic hypothermia in adult patients who had experienced hypoxic-ischemic brain injury following cardiopulmonary resuscitation. METHODS: In order to achieve our goal, we conducted an extensive search of multiple databases including PubMed, Embase, Cochrane, and ClinicalTrials...
2023: Brain Circulation
https://read.qxmd.com/read/38000146/wild-white-capped-noddies-keep-a-cool-head-in-a-heated-situation
#28
JOURNAL ARTICLE
John A Lesku, Robert G Barker, Hannah Elmes, Kylie A Robert, Lauren Tworkowski, Travis L Dutka
Sunning, or sunbathing, is a behavior observed in diverse birds from at least 50 taxonomic families. While sunning, birds exhibit signs of heat stress, notably panting, indicating a risk of overheating. Given that even modest increases in brain temperature can impair brain function, sunning birds may have mechanisms that selectively cool the brain. Sunning birds could cool the brain using active physiological mechanisms (e.g., an ophthalmic rete or sleeping) or passive adaptations, such as light-colored plumage over the cranium...
November 21, 2023: Journal of Thermal Biology
https://read.qxmd.com/read/37976141/neurovascular-interventions-for-neurotrauma-from-treatment-of-injured-vessels-to-treatment-of-the-injured-brain
#29
JOURNAL ARTICLE
Omer Doron, Aman B Patel, Gregory W J Hawryluk
Traumatic brain injury is often associated with a direct or secondary neurovascular pathology. In this review, we present recent advancements in endovascular neurosurgery that enable accurate and effective vessel reconstruction with emphasis on its role in early diagnosis, the expanding use of flow diversion in pseudoaneurysms, and traumatic arteriovenous fistulas. In addition, future directions in which catheter-based interventions could potentially affect traumatic brain injury are described: targeting blood brain barrier integrity using the advantages of intra-arterial drug delivery of blood brain barrier stabilizers to prevent secondary brain edema, exploring the impact of endovascular venous access as a means to modulate venous outflow in an attempt to reduce intracranial pressure and augment brain perfusion, applying selective intra-arterial hypothermia as a neuroprotection method mitigating some of the risks conferred by systemic cooling, trans-vessel wall delivery of regenerative therapy agents, and shifting attention using multimodal neuromonitoring to post-traumatic vasospasm to further characterize the role it plays in secondary brain injury...
November 17, 2023: Operative Neurosurgery (Hagerstown, Md.)
https://read.qxmd.com/read/37973473/risk-factors-for-brain-injury-in-patients-with-exertional-heatstroke-a-5-year-experience
#30
JOURNAL ARTICLE
Li Zhong, Ming Wu, Zhe-Ying Liu, Yan Liu, Zhi-Feng Liu
PURPOSE: Minimal data exist on brain injury in patients with exertional heatstroke (EHS) in developing country. In this study, we explored the risk factors for brain injury induced by EHS 90-day after onset. METHODS: A retrospective cohort study of patients with EHS was conducted in the intensive care unit of the General Hospital of Southern Theater Command in China from April 2014 to June 2019. Patients were divided into non-brain injury (fully recovered) and brain injury groups (comprising deceased patients or those with neurological sequelae)...
November 3, 2023: Chinese Journal of Traumatology
https://read.qxmd.com/read/37969549/expression-of-trematode-induced-zombie-ant-behavior-is-strongly-associated-with-temperature
#31
JOURNAL ARTICLE
Simone Nordstrand Gasque, Brian Lund Fredensborg
Parasite-induced modification of host behavior increasing transmission to a next host is a common phenomenon. However, field-based studies are rare, and the role of environmental factors in eliciting host behavioral modification is often not considered. We examined the effects of temperature, relative humidity (RH), time of day, date, and an irradiation proxy on behavioral modification of the ant Formica polyctena (Förster, 1850) by the brain-encysting lancet liver fluke Dicrocoelium dendriticum (Rudolphi, 1819)...
2023: Behavioral Ecology
https://read.qxmd.com/read/37966570/therapeutic-management-of-ischemic-stroke
#32
REVIEW
Priya Bindal, Vishal Kumar, Lakshay Kapil, Charan Singh, Arti Singh
Stroke is the third leading cause of years lost due to disability and the second-largest cause of mortality worldwide. Most occurrences of stroke are brought on by the sudden occlusion of an artery (ischemic stroke), but sometimes they are brought on by bleeding into brain tissue after a blood vessel has ruptured (hemorrhagic stroke). Alteplase is the only therapy the American Food and Drug Administration has approved for ischemic stroke under the thrombolysis category. Current views as well as relevant clinical research on the diagnosis, assessment, and management of stroke are reviewed to suggest appropriate treatment strategies...
November 15, 2023: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/37965166/selective-head-cooling-in-the-acute-phase-of-concussive-injury-a-neuroimaging-study
#33
JOURNAL ARTICLE
Alexa E Walter, Xiaoxiao Bai, James Wilkes, Thomas Neuberger, Wayne Sebastianelli, Semyon M Slobounov
INTRODUCTION: Neurovascular decoupling is a common consequence after brain injuries like sports-related concussion. Failure to appropriately match cerebral blood flow (CBF) with increases in metabolic demands of the brain can lead to alterations in neurological function and symptom presentation. Therapeutic hypothermia has been used in medicine for neuroprotection and has been shown to improve outcome. This study aimed to examine the real time effect of selective head cooling on healthy controls and concussed athletes via magnetic resonance spectroscopy (MRS) and arterial spin labeling (ASL) measures...
2023: Frontiers in Neurology
https://read.qxmd.com/read/37945342/optimising-a-product-standard-for-banning-menthol-and-other-flavours-in-tobacco-products
#34
EDITORIAL
Christina N Kyriakos, Janet Chung-Hall, Lorraine V Craig, Geoffrey T Fong
In this paper, we highlight key issues that policymakers should consider when developing a product standard banning menthol and other flavours in tobacco products based on research evidence and experiences learnt from other countries. A flavour product standard may be optimised by (1) having a clear and comprehensive definition of flavour that includes a complete ban on additives that have flavour properties and/or evoke sensory/cooling effects (ie, menthol analogues and synthetic coolants that stimulate the cooling receptor of the brain) rather than only as a 'characterising flavour' and (2) applying the standard to all tobacco product categories as well as all components or parts of the tobacco product (ie, the tobacco, filter, wrapper or paper), including separate flavourings that can be added to the product...
November 9, 2023: Tobacco Control
https://read.qxmd.com/read/37942702/magnetic-cortical-oscillations-associated-with-subjective-auditory-coolness-during-paired-comparison-of-time-varying-hvac-sounds
#35
JOURNAL ARTICLE
Hajime Yano, Tetsuya Takiguchi, Seiji Nakagawa
The impressions of heating, ventilation, and air conditioning (HVAC) sounds are important for the comfort people experience in their living spaces. Revealing neural substrates of the impressions induced by HVAC sounds can help to develop neurophysiological indices of the comfort of HVAC sounds. There have been numerous studies on the brain activities associated with the pleasantness of sounds, but few on the brain activities associated with the thermal impressions of HVAC sounds. Seven time-varying HVAC sounds were synthesized as stimuli using amplitude modulation...
October 30, 2023: Neuroreport
https://read.qxmd.com/read/37923196/effect-of-systemic-hydrocortisone-on-brain-abnormalities-and-regional-brain-volumes-in-ventilator-dependent-infants-born-preterm-substudy-of-the-stop-bpd-study
#36
RANDOMIZED CONTROLLED TRIAL
Nienke M Halbmeijer, Wes Onland, Jeroen Dudink, Filip Cools, Anne Debeer, Anton H van Kaam, Manon J N L Benders, Niek E van der Aa
OBJECTIVE: To evaluate whether a high cumulative dose of systemic hydrocortisone affects brain development compared with placebo when initiated between 7 and 14 days after birth in ventilated infants born preterm. STUDY DESIGN: A double-blind, placebo-controlled, randomized trial was conducted in 16 neonatal intensive care units among infants born at <30 weeks of gestation or with a birth weight of <1250 g who were ventilator-dependent in the second week after birth...
February 2024: Journal of Pediatrics
https://read.qxmd.com/read/37922827/sleep-and-global-warming-how-will-we-sleep-when-the-earth-is-hotter
#37
JOURNAL ARTICLE
Alain Buguet, Jacques Reis, Manny W Radomski
Societal concern about climate change and global warming has grown worldwide along with the concomitant awareness that health will be impacted deeply. Among living beings, humans have quite large capacities for adaptation to varied temperature conditions. Despite their tropical origin, they live under all Earth climates, such as polar, temperate, altitude, arid, and tropical climates, using a wide range of behavioral and physiological adaptive responses. We address the adaptive abilities of human sleep-wake regulation and its interplay with thermoregulation under different natural climates...
October 28, 2023: Journal of the Neurological Sciences
https://read.qxmd.com/read/37922826/heatwaves-and-human-sleep-stress-response-versus-adaptation
#38
JOURNAL ARTICLE
Alain Buguet, Manny W Radomski, Jacques Reis, Peter S Spencer
The World Meteorological Organization considers a heatwave as "a period of statistically unusual hot weather persisting for a number of days and nights". Accompanying the ongoing global climate change, sharp heatwave bouts occur worldwide, growing in frequency and intensity, and beginning earlier in the season. Heatwaves exacerbate the risk of heat-related illnesses, hence human morbidity and mortality, particularly in vulnerable elderly and children. Heat-related illnesses present a continuum from normothermic (prickly heat, heat edema, heat cramps, heat tetany) to hyperthermic syndromes (from heat syncope and heat exhaustion to lethal heat stroke)...
October 30, 2023: Journal of the Neurological Sciences
https://read.qxmd.com/read/37919618/fgf2-functions-in-h-2-s-s-attenuating-effect-on-brain-injury-induced-by-deep-hypothermic-circulatory-arrest-in-rats
#39
JOURNAL ARTICLE
Yu-Xiang Zhu, Qin Yang, You-Peng Zhang, Zhi-Gang Liu
Deep hypothermic circulatory arrest (DHCA) can protect the brain during cardiac and aortic surgery by cooling the body, but meanwhile, temporary or permanent brain injury may arise. H2 S protects neurons and the central nervous system, especially from secondary neuronal injury. We aim to unveil part of the mechanism of H2 S's attenuating effect on brain injury induced by DHCA by exploring crucial target genes, and further promote the clinical application of H2 S in DHCA. Nine SD rats were utilized to provide histological and microarray samples, and further the differential expression analysis...
November 2, 2023: Molecular Biotechnology
https://read.qxmd.com/read/37918856/sarin-induced-neuroinflammation-in-mouse-brain-is-attenuated-by-the-caspase-inhibitor-q-vd-oph
#40
JOURNAL ARTICLE
Ekta J Shah, William C Grunwald, Teresa L Garrett, Thomas L Brown, David R Cool
Organophosphates cause hyperstimulation of the CNS, leading to extended seizures, convulsions, and brain damage. Sarin is a highly toxic organophosphate nerve agent that has been employed in several terrorist attacks. The prolonged toxicity of sarin may be enhanced by the neuroinflammatory response initiated by the inflammasome, caspase involvement, and generation/release of pro-inflammatory cytokines. Since neurodegeneration and neuroinflammation are prevalent in sarin-exposed animals, we were interested in evaluating the capacity of Q-VD-OPh, a pan caspase inhibitor to attenuate neuro-inflammation following sarin exposure...
November 2, 2023: Journal of Pharmacology and Experimental Therapeutics
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