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https://www.readbyqxmd.com/read/27884679/risk-stratified-staging-in-paediatric-hepatoblastoma-a-unified-analysis-from-the-children-s-hepatic-tumors-international-collaboration
#1
Rebecka L Meyers, Rudolf Maibach, Eiso Hiyama, Beate Häberle, Mark Krailo, Arun Rangaswami, Daniel C Aronson, Marcio H Malogolowkin, Giorgio Perilongo, Dietrich von Schweinitz, Marc Ansari, Dolores Lopez-Terrada, Yukichi Tanaka, Rita Alaggio, Ivo Leuschner, Tomoro Hishiki, Irene Schmid, Kenichiro Watanabe, Kenichi Yoshimura, Yurong Feng, Eugenia Rinaldi, Davide Saraceno, Marisa Derosa, Piotr Czauderna
BACKGROUND: Comparative assessment of treatment results in paediatric hepatoblastoma trials has been hampered by small patient numbers and the use of multiple disparate staging systems by the four major trial groups. To address this challenge, we formed a global coalition, the Children's Hepatic tumors International Collaboration (CHIC), with the aim of creating a common approach to staging and risk stratification in this rare cancer. METHODS: The CHIC steering committee-consisting of leadership from the four major cooperative trial groups (the International Childhood Liver Tumours Strategy Group, Children's Oncology Group, the German Society for Paediatric Oncology and Haematology, and the Japanese Study Group for Paediatric Liver Tumours)-created a shared international database that includes comprehensive data from 1605 children treated in eight multicentre hepatoblastoma trials over 25 years...
November 21, 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27530723/clinical-features-and-management-of-multifocal-hepatic-hemangiomas-in-children-a-retrospective-study
#2
Yi Ji, Siyuan Chen, Bo Xiang, Zhicheng Xu, Xiaoping Jiang, Xingtao Liu, Qi Wang, Guoyan Lu, Li Yang
Multifocal hepatic hemangioma (MHH) is a benign hepatic tumor that is commonly diagnosed in children with multiple cutaneous infantile hemangiomas (IHs). We present a review of all children with MHH at our institutions. Of the 42 patients, the median age at presentation of MHH was 2.5 months. Thirty-six (85.7%) patients had cutaneous IHs. Twelve (28.6%) patients were symptomatic at presentation. There was no significant association between the number of hepatic hemangiomas and the number of cutaneous IHs. Fourteen (33...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27509487/residential-proximity-to-environmental-pollution-sources-and-risk-of-rare-tumors-in-children
#3
Javier García-Pérez, Antonio Morales-Piga, Diana Gómez-Barroso, Ibon Tamayo-Uria, Elena Pardo Romaguera, Gonzalo López-Abente, Rebeca Ramis
BACKGROUND: Few epidemiologic studies have explored risk factors for rare tumors in children, and the role of environmental factors needs to be assessed. OBJECTIVES: To ascertain the effect of residential proximity to both industrial and urban areas on childhood cancer risk, taking industrial groups into account. METHODS: We conducted a population-based case-control study of five childhood cancers in Spain (retinoblastoma, hepatic tumors, soft tissue sarcomas, germ cell tumors, and other epithelial neoplasms/melanomas), including 557 incident cases from the Spanish Registry of Childhood Tumors (period 1996-2011), and 3342 controls individually matched by year of birth, sex, and region of residence...
August 7, 2016: Environmental Research
https://www.readbyqxmd.com/read/27289416/computer-assisted-surgery-planning-in-children-with-complex-liver-tumors-identifies-variability-of-the-classical-couinaud-classification
#4
Steven W Warmann, Andrea Schenk, Juergen F Schaefer, Martin Ebinger, Gunnar Blumenstock, Ilias Tsiflikas, Joerg Fuchs
BACKGROUND: In complex malignant pediatric liver tumors there is an ongoing discussion regarding surgical strategy; for example, primary organ transplantation versus extended resection in hepatoblastoma involving 3 or 4 sectors of the liver. We evaluated the possible role of computer-assisted surgery planning in children with complex hepatic tumors. METHODS: Between May 2004 and March 2016, 24 Children with complex liver tumors underwent standard multislice helical CT scan or MRI scan at our institution...
June 1, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/26901874/alagille-syndrome-candidates-for-liver-transplantation-differentiation-from-end-stage-biliary-atresia-using-preoperative-ct
#5
Sook Min Hwang, Tae Yeon Jeon, So-Young Yoo, Ji Hye Kim, Ben Kang, Yon Ho Choe, Haeyon Cho, Jung Sun Kim
PURPOSE: To compare preoperative CT findings before liver transplantation between patients with Alagille syndrome (AGS) and those with end-stage biliary atresia (BA). MATERIALS AND METHODS: The institutional review board approved this retrospective study. Eleven children with AGS (median age, 19.0 ± 13.0 months; male to female ratio, 3:8) and 109 children with end-stage BA (median age, 17.9 ± 25.8 months; male to female ratio, 37:72) who underwent abdomen CT as candidates for liver transplant were included...
2016: PloS One
https://www.readbyqxmd.com/read/26655560/the-children-s-hepatic-tumors-international-collaboration-chic-novel-global-rare-tumor-database-yields-new-prognostic-factors-in-hepatoblastoma-and-becomes-a-research-model
#6
MULTICENTER STUDY
Piotr Czauderna, Beate Haeberle, Eiso Hiyama, Arun Rangaswami, Mark Krailo, Rudolf Maibach, Eugenia Rinaldi, Yurong Feng, Daniel Aronson, Marcio Malogolowkin, Kenichi Yoshimura, Ivo Leuschner, Dolores Lopez-Terrada, Tomoro Hishiki, Giorgio Perilongo, Dietrich von Schweinitz, Irene Schmid, Kenichiro Watanabe, Marisa Derosa, Rebecka Meyers
INTRODUCTION: Contemporary state-of-the-art management of cancer is increasingly defined by individualized treatment strategies. For very rare tumors, like hepatoblastoma, the development of biologic markers, and the identification of reliable prognostic risk factors for tailoring treatment, remains very challenging. The Children's Hepatic tumors International Collaboration (CHIC) is a novel international response to this challenge. METHODS: Four multicenter trial groups in the world, who have performed prospective controlled studies of hepatoblastoma over the past two decades (COG; SIOPEL; GPOH; and JPLT), joined forces to form the CHIC consortium...
January 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/26229397/benign-liver-tumors-in-pediatric-patients-review-with-emphasis-on-imaging-features
#7
REVIEW
Liliana Chiorean, Xin-Wu Cui, Andrea Tannapfel, Doris Franke, Martin Stenzel, Wojciech Kosiak, Dagmar Schreiber-Dietrich, Jörg Jüngert, Jian-Min Chang, Christoph F Dietrich
Benign hepatic tumors are commonly observed in adults, but rarely reported in children. The reasons for this remain speculative and the exact data concerning the incidence of these lesions are lacking. Benign hepatic tumors represent a diverse group of epithelial and mesenchymal tumors. In pediatric patients, most benign focal liver lesions are inborn and may grow like the rest of the body. Knowledge of pediatric liver diseases and their imaging appearances is essential in order to make an appropriate differential diagnosis...
July 28, 2015: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/25695679/thymosin-%C3%AE-4-promotes-hepatoblastoma-metastasis-via-the-induction-of-epithelial-mesenchymal-transition
#8
Xiaojun Fu, Peiyuan Cui, Fangfang Chen, Jianzhong Xu, Li Gong, Lei Jiang, Dakun Zhang, Yongtao Xiao
Hepatoblastoma (HB) is the most common malignant hepatic tumor in children and complete surgical resection offers the highest possibility for cure in this disease. Tumor metastasis is the principle obstacle to the development of efficient treatments for patients with HB. The present study aimed to measure the expression levels of thymosin β4 (Tβ4) in liver samples from patients with HB and to investigate the involvement of Tβ4 in HB metastasis. The expression of Tβ4 was significantly higher in liver samples from patients with metastatic HB and in the HepG2 metastatic HB cell line, compared with that in adjacent healthy liver samples and in the L02 healthy hepatic cell line...
July 2015: Molecular Medicine Reports
https://www.readbyqxmd.com/read/25599927/incidence-of-cancer-in-children-aged-0-14-years-in-taiwan-1996-2010
#9
Yen-Lin Liu, Wei-Cheng Lo, Chun-Ju Chiang, Ya-Wen Yang, Meng-Yao Lu, Wen-Ming Hsu, Wan-Ling Ho, Meng-Ju Li, James S Miser, Dong-Tsamn Lin, Mei-Shu Lai
Studies have found lower risk of childhood cancer among Asian children. We aim to characterize the recent incidence and incidence-trend of childhood cancer in Taiwan after the National Health Insurance program was launched in March 1995. Data were extracted from the Taiwan Cancer Registry, a population-based database established in 1979. Cases diagnosed at age 0-14 from 1996 to 2010 were analyzed and categorized according to the International Classification of Childhood Cancer, Third Edition (ICCC-3). In total, 8032 childhood cancer cases were included, with a microscopic verification rate of 93...
February 2015: Cancer Epidemiology
https://www.readbyqxmd.com/read/25131326/laparoscopic-resection-of-hepatoblastoma-report-of-a-case
#10
Keigo Yada, Hiroki Ishibashi, Hiroki Mori, Mitsuo Shimada
Despite the increasing number of recent reports on laparoscopic resection of malignant liver tumors in adults, there have been few reports involving children. In this paper we discuss the laparoscopic resection of a hepatoblastoma in a 1-year-old boy. The CT scan revealed an exophytic hepatic tumor on S5 measuring 6 × 5 × 4 cm after preoperative chemotherapy. The operation time was 225 min with an estimated blood loss of about 38 mL; intraoperative transfusion was not required. Radiofrequency-assisted precoagulation was performed...
August 2014: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/25043411/cancer-incidence-patterns-among-children-and-adolescents-in-taiwan-from-1995-to-2009-a-population-based-study
#11
Giun-Yi Hung, Jiun-Lin Horng, Yu-Sheng Lee, Hsiu-Ju Yen, Chao-Chun Chen, Chih-Ying Lee
BACKGROUND: Currently, little information is available on childhood cancer incidence rates in Eastern Asia. The objective of this study was to report the first population-based cancer surveillance of children and adolescents in Taiwan. METHODS: Data from the Taiwan Cancer Registry were examined for cancer frequencies and incidence rates among individuals ages birth to 19 years from 1995 to 2009. Types of cancers were grouped according to the International Classification of Childhood Cancer...
November 15, 2014: Cancer
https://www.readbyqxmd.com/read/25012068/the-impact-of-share-wave-elastography-in-differentiation-of-hepatic-hemangioma-from-malignant-liver-tumors-in-pediatric-population
#12
Evrim Özmen, Ibrahim Adaletli, Yasemin Kayadibi, Şenol Emre, Fahrettin Kiliç, Sergülen Dervişoğlu, Sebuh Kuruğoğlu, Osman Faruk Şenyüz
OBJECTIVE: In children it is crucial to differentiate malignant liver tumors from the most common benign tumor, hepatic hemangiomas since the treatment strategies are quite different. We aimed to evaluate the efficiency of shear wave elastography (SWE) technique in differentiation of malignant hepatic tumors and hepatic hemangiomas. METHODS: Twenty patients with hepatic tumor were included in our study. Two radiologists performed SWE for 13 patients with malignant hepatic tumors including hepatoblastoma (n=7), hepatocellular carcinoma (n=3), metastasis (n=2), embryonal sarcoma (n=1) and 7 patients with hepatic hemangioma...
September 2014: European Journal of Radiology
https://www.readbyqxmd.com/read/24364200/-diffuse-infantile-hepatic-hemangioendothelioma-a-case-report
#13
Ivica Sjekavica, Marko Petrovecki, Vice Sunjara, Maja Pavlović, Ranka Stern Padovan
Infantile hepatic hemangioendothelioma (IHHE) is the most common benign hepatic tumor in children (12% of hepatic tumors), that usually responds well to therapy and has low mortality rates. In extremely rare cases of diffuse tumors resistant to therapy, size and blood flow can lead to cardiorespiratory failure and death. A 3-month-old male infant presented with respiratory infections and an abdominal mass, with frequent broncho-obstructive attacks. The CT, MRI and DSA exams showed typical morphology of hemangiendothelioma that was proven on histopathological biopsy...
September 2013: Lijec̆nic̆ki Vjesnik
https://www.readbyqxmd.com/read/24322718/hepatoblastoma-state-of-the-art-pathology-genetics-risk-stratification-and-chemotherapy
#14
REVIEW
Piotr Czauderna, Dolores Lopez-Terrada, Eiso Hiyama, Beate Häberle, Marcio H Malogolowkin, Rebecka L Meyers
PURPOSE OF REVIEW: As a rare pediatric tumor, hepatoblastoma presents challenges to the individual practitioner as no center will see more than a handful of cases each year. RECENT FINDINGS: The Children's Hepatic tumor International Collaborative (CHIC) effort has fostered international cooperation in this rare children's tumor, leading to the establishment of a large international collaborative dataset, the CHIC database, which has been interrogated to refine risk stratification and inform treatment options...
February 2014: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/24210186/treatment-of-undifferentiated-embryonal-sarcoma-of-the-liver-in-children-single-center-experience
#15
Hor Ismail, Bożenna Dembowska-Bagińska, Dorota Broniszczak, Piotr Kaliciński, Przemysław Maruszewski, Przemysław Kluge, Ewa Swięszkowska, Andrzej Kościesza, Agnieszka Lembas, Danuta Perek
BACKGROUND: Undifferentiated embryonal sarcoma of the liver (UESL) represents less than 5% of all malignant hepatic tumors in childhood. It is considered an aggressive neoplasm with an unfavorable prognosis. The aim of this paper is to present a single center experience in the treatment of children with UESL. MATERIALS AND METHODS: Ten children with UESL were treated between 1981 and 2012. Age at diagnosis ranged from 4 months to 17 years (median age, 6 years and 9 months)...
November 2013: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/24106687/xanthogranulomatous-cholecystits-in-2-month-old-infant
#16
Soo-Hong Kim, Hyun-Young Kim, Sung-Eun Jung, Kwi-Won Park, Young Hun Choi, Woo-Sun Kim, Sung-Hye Park
Xanthogranulomatous cholecystitis (XGC) is a rare form of chronic cholecystitis that is accompanied by xanthomatous histiocytes and chronic inflammation. A 2-month-old boy presented with a right upper abdominal palpable mass. Cholecystectomy with liver wedge resection was done, under the impression that the mass might be a hepatic tumor or liver abscess. Pathologic examination showed XGC with abscess formation. Most cases of XGC were observed in adult and only a few cases were reported in children. We describe a very rare case of XGC in infancy...
October 2013: Journal of the Korean Surgical Society
https://www.readbyqxmd.com/read/24057320/current-therapeutic-strategies-for-childhood-hepatic-malignant-tumors
#17
Eiso Hiyama
The two main malignant hepatic tumors in children are hepatoblastomas (HBLs) and hepatocellular carcinomas (HCCs). The past two decades have brought significant improvement to the outcomes of children diagnosed with malignant hepatic tumors, especially HBL, due to improvements in diagnosis and treatment. Histological diagnosis is essential for differential diagnosis of these tumors. In surgery, liver resection has become a safe and secure technique because of progress in anatomical knowledge and surgical dissection; also liver transplantation has become widely used for unresectable tumors...
December 2013: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/24038117/undifferentiated-sarcoma-of-the-liver-a-case-study-of-an-erythropoietin-secreting-tumor
#18
JoAnn M Lin, Jonathon E Heath, William S Twaddell, Rudy J Castellani
Undifferentiated embryonal sarcoma of the liver (UESL) is an uncommon hepatic tumor usually found in children, with rare cases reported in adults. We present a case of a 53-year-old woman with an undifferentiated sarcoma of the liver (USL), which resembles UESL, who initially presented with a markedly elevated hematocrit (61.2%). Cytogenetic studies for polycythemia vera were negative, but the patient's erythropoietin (EPO) was elevated. A computed tomography scan and subsequent partial hepatectomy revealed a well-circumscribed, partially cystic mass in the right lobe of the liver measuring 34 cm...
September 2014: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/24026876/a-cisplatin-plus-pirarubicin-based-jplt2-chemotherapy-for-hepatoblastoma-experience-and-future-of-the-japanese-study-group-for-pediatric-liver-tumor-jplt
#19
RANDOMIZED CONTROLLED TRIAL
Eiso Hiyama, Yuka Ueda, Yoshiyuki Onitake, Shou Kurihara, Kenichiro Watanabe, Tomoro Hishiki, Tatsuro Tajiri, Komei Ida, Michihiro Yano, Satoshi Kondo, Takaharu Oue
INTRODUCTION: The Japanese Study Group for Pediatric Liver Tumor (JPLT) has conducted cooperative treatment studies on hepatoblastoma (HBL) since 1991. The JPLT2 protocol was launched in 1999 to evaluate the efficacy of cisplatin/pirarubicin (CITA) under risk stratification. European and North American groups showed the improvement of HBL patients by pre- and postoperative chemotherapeutic regimens. Therefore, we evaluated the results of JPLT study and considered the future aspect of JPLT...
October 2013: Pediatric Surgery International
https://www.readbyqxmd.com/read/23988008/cancer-incidence-and-survival-among-infants-in-israel-1998-2007
#20
COMPARATIVE STUDY
Ron Rabinowicz, Micha Barchana, Irena Liphshiz, Shai Linn, Boris Futerman, Myriam Weyl Ben-Arush
Cancer during the first year of life is relatively rare and often has clinical and biological properties different from those of the same histologic type of cancer occurring in older children. The aim of this study was to find differences in epidemiology and survival between infants and older children and to compare the percentage of distribution of infant cancer types in Israel with that reported in the United States. We collected infant <1 year of age cases diagnosed between 1998 and 2007 as having cancer from the database of the Israel National Cancer Registry, a total of 309 cases with an incidence rate of 228...
October 2013: Pediatric Hematology and Oncology
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