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https://www.readbyqxmd.com/read/29788118/risk-factors-for-treatment-failure-and-mortality-among-hospitalised-patients-with-complicated-urinary-tract-infection-a-multicentre-retrospective-cohort-study-rescuing-study-group
#1
Noa Eliakim-Raz, Tanya Babitch, Evelyn Shaw, Ibironke Addy, Irith Wiegand, Christiane Vank, Laura Torre-Vallejo, Vigo Joan-Miquel, Morris Steve, Sally Grier, Margaret Stoddart, Cuperus Nienke, Leo van den Heuvel, Cuong Vuong, Alasdair MacGowan, Jordi Carratalà, Leonard Leibovici, Miquel Pujol
Background: Complicated urinary tract infections (cUTIs) are responsible for a major share of all antibiotic consumption in hospitals. We aim to describe risk factors for treatment failure and mortality among hospitalised patients with cUTIs. Methods: A multinational, multicentre retrospective cohort study, conducted in 20 countries in Europe and the Middle East. Data were collected from patients' files on hospitalised patients with a diagnosis of cUTI during 2013-2014...
May 17, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29745358/assessing-a-national-collaborative-program-to-prevent-catheter-associated-urinary-tract-infection-in-a-veterans-health-administration-nursing-home-cohort
#2
Sarah L Krein, M Todd Greene, Beth King, Deborah Welsh, Karen E Fowler, Barbara W Trautner, David Ratz, Sanjay Saint, Gary Roselle, Marla Clifton, Stephen M Kralovic, Tina Martin, Lona Mody
OBJECTIVECollaborative programs have helped reduce catheter-associated urinary tract infection (CAUTI) rates in community-based nursing homes. We assessed whether collaborative participation produced similar benefits among Veterans Health Administration (VHA) nursing homes, which are part of an integrated system.SETTINGThis study included 63 VHA nursing homes enrolled in the "AHRQ Safety Program for Long-Term Care," which focused on practices to reduce CAUTI.METHODSChanges in CAUTI rates, catheter utilization, and urine culture orders were assessed from June 2015 through May 2016...
May 10, 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29743326/reducing-urinary-catheter-use-a-protocol-for-a-mixed-methods-evaluation-of-an-electronic-reminder-system-in-hospitalised-patients-in-australia
#3
Oyebola Fasugba, Allen C Cheng, Philip L Russo, Maria Northcote, Hannah Rosebrock, Brett G Mitchell
INTRODUCTION: Despite advances in infection prevention and control, catheter-associated urinary tract infections (CAUTIs) are common and remain problematic. Prolonged urinary catheterisation is the main risk factor for development of CAUTIs; hence, interventions that target early catheter removal warrant investigation. The study's objectives are to examine the efficacy of an electronic reminder system, the CATH TAG, in reducing urinary catheter use (device utilisation ratio) and to determine the effect of the CATH TAG on nurses' ability to deliver patient care...
May 9, 2018: BMJ Open
https://www.readbyqxmd.com/read/29712426/hydrogen-sulfide-sensing-through-reactive-sulfur-species-rss-and-nitroxyl-hno-in-enterococcus-faecalis
#4
Jiangchuan Shen, Brenna J C Walsh, Ana Lidia Flores-Mireles, Hui Peng, Yifan Zhang, Yixiang Zhang, Jonathan C Trinidad, Scott J Hultgren, David P Giedroc
Recent studies of hydrogen sulfide (H2S) signaling implicate low molecular weight (LMW) thiol persulfides and other reactive sulfur species (RSS) as signaling effectors. Here, we show that a CstR protein from the human pathogen Enterococcus faecalis ( E. faecalis), previously identified in Staphylococcus aureus ( S. aureus), is an RSS-sensing repressor that transcriptionally regulates a cst-like operon in response to both exogenous sulfide stress and Angeli's salt, a precursor of nitroxyl (HNO). E. faecalis CstR reacts with coenzyme A persulfide (CoASSH) to form interprotomer disulfide and trisulfide bridges between C32 and C61' which negatively regulate DNA binding to a consensus CstR DNA operator...
April 30, 2018: ACS Chemical Biology
https://www.readbyqxmd.com/read/29665877/the-impact-of-2015-nhsn-catheter-associated-urinary-tract-infection-cauti-definition-change-on-central-line-associated-bloodstream-infection-clabsi-rates-and-clabsi-prevention-efforts-at-an-academic-medical-center
#5
Sonali D Advani, Rachael A Lee, Martha Long, Mariann Schmitz, Bernard C Camins
The 2015 changes in the catheter-associated urinary tract infection definition led to an increase in central line-associated bloodstream infections (CLABSIs) and catheter-related candidemia in some health systems due to the change in CLABSI attribution. However, our rates remained unchanged in 2015 and further declined in 2016 with the implementation of new vascular-access guidelines.Infect Control Hosp Epidemiol 2018;1-3.
April 18, 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29652969/-molecular-characterization-and-antimicrobial-susceptibility-pattern-of-extended-spectrum-%C3%AE-lactamase-producing-escherichia-coli-as-cause-of-community-acquired-urinary-tract-infection
#6
Mario Galindo-Méndez
Background Community acquired urinary tract infections (CaUTI) caused by strains of extended-spectrum β-lactamases (ESBL) - producing Escherichia coli, mainly by strains carrying the blaCTX-M-15 gene, is a growing phenomenon worldwide. Aim To determine the antibiotic susceptibility pattern of ESBL-producing E. coli as cause of CaUTI and to identify their molecular pattern. Methods A descriptive study was performed in the city of Oaxaca, Mexico, from where 288 strains of CaUTI-producing strains of E. coli in adults with possible UTI were isolated...
2018: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/29619335/role-of-neomycin-polymyxin-sulfate-solution-bladder-wash-for-prevention-of-catheter-associated-urinary-tract-infection-in-traumatic-brain-injury-patient-admitted-to-intensive-care-unit-a-prospective-randomized-study
#7
Neeraj Kumar, Yashpal Singh, Ghanshyam Yadav, S K Mathur, Umesh Kumar Bhadani
Background: Catheter - associated urinary tract infection (CAUTI) remains a critical threat for patients in intensive care unit especially in traumatic brain injury patients with low Glasgow coma score (GCS). Almost all patients in ICU receive antibiotic either prophylactic or therapeutic based on local antibiogram of particular ICU or hospital. For prophylaxis, systemic antibiotics are used. It will be helpful to avoid systemic side effects by introducing antibiotics locally through bladder irrigation...
January 2018: International Journal of Critical Illness and Injury Science
https://www.readbyqxmd.com/read/29551472/the-trauma-life-initiative-the-impact-of-a-multidisciplinary-checklist-process-on-outcomes-and-communication-in-a-trauma-intensive-care-unit
#8
Kimberly Joseph, Sameer Gupta, James Yon, Renee Partida, Lee Cartagena, John Kubasiak, Vanessa Buie, Jared Miller, Dorion Wiley, Kimberly Nagy, Frederic Starr, Andrew Dennis, Matthew Kaminsky, Faran Bokhari
BACKGROUND: Checklists have been advocated to improve quality outcomes/communication in the critical care setting, but results have been mixed. A new checklist process, "TRAUMA LIFE", was implemented in our Trauma Intensive Care Unit (TICU) to replace prior checklists. The purpose of this study was to evaluate the impact of the "TRAUMA LIFE" process implementation on quality metrics and on patient/family communication in the TICU. METHODS: "TRAUMA LIFE" was considered maturely implemented by 2016...
March 9, 2018: American Journal of Surgery
https://www.readbyqxmd.com/read/29551201/impact-of-a-change-in-surveillance-definition-on-performance-assessment-of-a-catheter-associated-urinary-tract-infection-prevention-program-at-a-tertiary-care-medical-center
#9
Madhuri M Sopirala, Asma Syed, Roman Jandarov, Margaret Lewis
BACKGROUND: In January 2015, the Centers for Disease Control and Prevention (CDC)/National Health Safety Network (NHSN) changed the definition of catheter-associated urinary tract infection (CAUTI). We evaluated the outcomes of a robust CAUTI prevention program when we performed surveillance using the old definition (before 2015) versus the new definition (after 2015). This is the first study to evaluate how the change in CDC/NHSN definitions affected the outcomes of a CAUTI reduction program...
March 16, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29521928/factors-associated-with-healthcare-acquired-catheter-associated-urinary-tract-infections-analysis-using-multiple-data-sources-and-data-mining-techniques
#10
Jung In Park, Donna Z Bliss, Chih-Lin Chi, Connie W Delaney, Bonnie L Westra
PURPOSE: The purpose of this study was to identify factors associated with healthcare-acquired catheter-associated urinary tract infections (HA-CAUTIs) using multiple data sources and data mining techniques. SUBJECTS AND SETTING: Three data sets were integrated for analysis: electronic health record data from a university hospital in the Midwestern United States was combined with staffing and environmental data from the hospital's National Database of Nursing Quality Indicators and a list of patients with HA-CAUTIs...
March 2018: Journal of Wound, Ostomy, and Continence Nursing
https://www.readbyqxmd.com/read/29489017/economic-evaluation-of-a-catheter-associated-urinary-tract-infection-prevention-program-in-nursing-homes
#11
David W Hutton, Sarah L Krein, Sanjay Saint, Nicholas Graves, Ajay Kolli, Raymond Lynem, Lona Mody
OBJECTIVE: To assess the economic effect and cost effectiveness of a targeted catheter-associated urinary tract infection (CAUTI) prevention intervention in the nursing home (NH) setting. DESIGN: Randomized clinical trial. SETTING: Community-based NHs (N=12). PARTICIPANTS: NH residents with indwelling urinary catheters (N=418). INTERVENTION: Standard care versus infection prevention program involving barrier precautions, active surveillance, and NH staff education...
April 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29478760/the-attributable-cost-of-catheter-associated-urinary-tract-infections-in-the-united-states-a-systematic-review
#12
Christopher S Hollenbeak, Amber L Schilling
BACKGROUND: Catheter-associated urinary tract infections (CAUTIs) are the most common healthcare-acquired condition. The attributable cost of CAUTIs is frequently cited to be approximately $1,000. However, there is a paucity of recent literature that confirms this estimate. The purpose of this study was to perform a systematic review of the literature that estimates the attributable cost of CAUTIs in the United States. METHODS: A systematic review was conducted using Pubmed...
February 22, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29445984/impact-of-antibiotic-prophylaxis-on-catheter-associated-urinary-tract-infections-during-atrial-fibrillation-ablation
#13
David E Lewandowski, David Pierce, Anne Barnett, Emmanuel Sampene, Nasia Safdar, Michael E Field, Jennifer M Wright
PURPOSE: Urinary catheter placement is common during atrial fibrillation (AF) ablation when performed under general anesthesia. Whether patients undergoing AF ablation would benefit from prophylactic antibiotics is unknown. METHODS: Patients undergoing AF ablation in a single center from December 2011 until June 2016 were included. All patients received urinary catheters and general anesthesia. After June 2014, patients received antibiotic prophylaxis with a single dose of oral nitrofurantoin and a catheter insertion checklist performed prior to urinary catheter placement...
March 2018: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/29426705/is-a-project-needed-to-prevent-urinary-tract-infection-in-patients-admitted-to-spanish-icus
#14
F Álvarez Lerma, P Olaechea Astigarraga, X Nuvials, R Gimeno, M Catalán, M P Gracia Arnillas, I Seijas Betolaza, M Palomar Martínez
OBJECTIVE: To analyze epidemiological data of catheter-associated urinary tract infection (CAUTI) in critically ill patients admitted to Spanish ICUs in order to assess the need of implementing a nationwide intervention program to reduce these infections. DESIGN: Non-intervention retrospective annual period prevalence analysis. SETTING: Participating ICUs in the ENVIN-UCI multicenter registry between the years 2007-2016. PATIENTS: Critically ill patients admitted to the ICU with catheter-associated urinary tract infection (CAUTI)...
February 6, 2018: Medicina Intensiva
https://www.readbyqxmd.com/read/29424333/pathogenesis-of-proteus-mirabilis-infection
#15
Chelsie E Armbruster, Harry L T Mobley, Melanie M Pearson
Proteus mirabilis , a Gram-negative rod-shaped bacterium most noted for its swarming motility and urease activity, frequently causes catheter-associated urinary tract infections (CAUTIs) that are often polymicrobial. These infections may be accompanied by urolithiasis, the development of bladder or kidney stones due to alkalinization of urine from urease-catalyzed urea hydrolysis. Adherence of the bacterium to epithelial and catheter surfaces is mediated by 17 different fimbriae, most notably MR/P fimbriae...
February 2018: EcoSal Plus
https://www.readbyqxmd.com/read/29422728/multicenter-observational-study-to-evaluate-epidemiology-and-resistance-patterns-of-common-intensive-care-unit-infections
#16
Ramesh Venkataraman, Jigeeshu V Divatia, Nagarajan Ramakrishnan, Rajesh Chawla, Pravin Amin, Palepu Gopal, Dhruva Chaudhry, Kapil Zirpe, Babu Abraham
Background: There is limited data regarding the microbiology of Intensive Care Unit (ICU)-acquired infections, such as ventilator-associated pneumonia (VAP), catheter-associated urinary tract infections (CAUTI), and catheter-related bloodstream infections (CRBSI) from India. Objectives: To explore the microbiology and resistance patterns of ICU-acquired infections and evaluate their outcomes. Materials and Methods: This was a multicenter observational study, conducted by Indian Society of Critical Care Medicine (MOSER study) between August 2011 and October 2012...
January 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29397230/effectiveness-of-a-bundled-approach-to-reduce-urinary-catheters-and-infection-rates-in-trauma-patients
#17
Paige E Davies, Mitchell J Daley, Jonathan Hecht, Athena Hobbs, Caroline Burger, Lynda Watkins, Taya Murray, Katherine Shea, Sadia Ali, Lawrence H Brown, Thomas B Coopwood, Carlos V R Brown
BACKGROUND: Catheter-associated urinary tract infections (CAUTIs) are common nosocomial infections. In 2015, the Centers for Medicare and Medicaid Services began imposing financial penalties for institutions where CAUTI rates are higher than predicted. However, the surveillance definition for CAUTI is not a clinical diagnosis and may represent asymptomatic bacteriuria. The objective of this study was to compare rates of urinary catheterization and CAUTI before and after the implementation of a bundled intervention...
January 31, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29395511/healthcare-associated-infections-in-the-neurological-intensive-care-unit-results-of-a-6-year-surveillance-study-at-a-major-tertiary-care-center
#18
Yasser B Abulhasan, Susan P Rachel, Marc-Olivier Châtillon-Angle, Najayeb Alabdulraheem, Ian Schiller, Nandini Dendukuri, Mark R Angle, Charles Frenette
BACKGROUND: Healthcare-associated infections (HAIs) occur frequently in neurological intensive care units (neuro-ICUs); however, data differentiating associations with various diagnostic categories and resulting burdens are limited. This prospective cohort study reported incidence rates, pathogen distribution, and patient-related outcomes of HAIs in a neuro-ICU population from April 2010 to March 2016. METHODS: Laboratory results and specific clinical indicators were used to categorize infections as per National Healthcare Safety Network nosocomial infection surveillance definitions...
January 25, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29351769/protocol-to-disseminate-a-hospital-site-controlled-intervention-using-audit-and-feedback-to-implement-guidelines-concerning-inappropriate-treatment-of-asymptomatic-bacteriuria
#19
Barbara W Trautner, Pooja Prasad, Larissa Grigoryan, Sylvia J Hysong, Jennifer R Kramer, Suja Rajan, Nancy J Petersen, Tracey Rosen, Dimitri M Drekonja, Christopher Graber, Payal Patel, Paola Lichtenberger, Timothy P Gauthier, Steve Wiseman, Makoto Jones, Anne Sales, Sarah Krein, Aanand Dinkar Naik
BACKGROUND: Antimicrobial stewardship to combat the spread of antibiotic-resistant bacteria has become a national priority. This project focuses on reducing inappropriate use of antimicrobials for asymptomatic bacteriuria (ASB), a very common condition that leads to antimicrobial overuse in acute and long-term care. We previously conducted a successful intervention, entitled "Kicking Catheter Associated Urinary Tract Infection (CAUTI): the No Knee-Jerk Antibiotics Campaign," to decrease guideline-discordant ordering of urine cultures and antibiotics for ASB...
January 19, 2018: Implementation Science: IS
https://www.readbyqxmd.com/read/29332116/applying-preventive-measures-leading-to-significant-reduction-of-catheter-associated-urinary-tract-infections-in-adult-intensive-care-unit
#20
Fahad M Al-Hameed, Gulam R Ahmed, Asim A AlSaedi, Muhammad J Bhutta, Faisal F Al-Hameed, Majid M AlShamrani
To determine the impact of applying the best available clinical evidence on the preventive measures to reduce the rate of catheter-associated urinary tract infections (CAUTI) in adult intensive care units (ICU).     Methods:  Data were collected from adult ICUs (28 beds) from 2008 to 2016. The proper use of silicon catheter, aseptic insertion technique, emptying bag three-fourth via close circuit, the use of appropriate size catheter, securing the draining tube on the thigh to keep catheter bag below patient's bladder level and removal of the catheter as early as possible were ensured in all patients...
January 2018: Saudi Medical Journal
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