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https://www.readbyqxmd.com/read/28100054/efficacy-of-silver-hydrophilic-poly-p-xylylene-on-preventing-bacterial-growth-and-biofilm-formation-in-urinary-catheters
#1
Hamideh Heidari Zare, Viktorija Juhart, Attila Vass, Gerhard Franz, Dieter Jocham
Catheter associated urinary tract infections (CAUTI), caused by several strains of bacteria, are a common complication for catheterized patients. This may eventually lead to a blockage of the catheter due to the formation of a crystalline or amorphous biofilm. Inhibiting bacteria should result in a longer application time free of complaints. This issue has been investigated using an innovative type of silver-coated catheter with a semipermeable cap layer to prevent CAUTI. In this work, two different types of silver catheters were investigated, both of which were capped with poly(p-xylylene) (PPX-N) and exhibited different surface properties that completely changed their wetting conduct with water...
January 18, 2017: Biointerphases
https://www.readbyqxmd.com/read/28096455/multicenter-prospective-study-on-device-associated-infection-rates-and-bacterial-resistance-in-intensive-care-units-of-venezuela-international-nosocomial-infection-control-consortium-inicc-findings
#2
Gabriel D Empaire, Maria E Guzman Siritt, Victor D Rosenthal, Fernando Pérez, Yvis Ruiz, Claudia Díaz, Gabriela Di Silvestre, Evelyn Salinas, Nelva Orozco
BACKGROUND: Device-associated healthcare-acquired infections (DA-HAI) pose a threat to patient safety in the intensive care unit (ICU). METHODS: A DA-HAI surveillance study was conducted by the International Nosocomial Infection Control Consortium (INICC) in two adult medical/surgical ICUs at two hospitals in Caracas, Venezuela, in different periods from March 2008 to April 2015, using the US Centers for Disease Control and Prevention's National Healthcare Safety Network (CDC/NHSN) definitions and criteria, and INICC methods...
January 2017: International Health
https://www.readbyqxmd.com/read/28069123/pepsin-diffusion-in-dairy-gels-depends-on-casein-concentration-and-microstructure
#3
J Thévenot, C Cauty, D Legland, D Dupont, J Floury
Fundamental knowledge of gastric digestion had only focused on acid diffusion from the gastric fluid, but no data are available for pepsin diffusion. Using fluorescence recovery after photobleaching technique, diffusion coefficients D of fluorescein isothiocyanate (FITC)-pepsin were measured in rennet gels across a range of casein concentrations allowing to form networks of protein aggregates with different structures. To investigate the microstructural parameters of native gels, electron microscopy image analysis were performed and qualitatively related to diffusion behavior of FITC-pepsin in these dairy gels...
May 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28057985/the-efficacy-of-noble-metal-alloy-urinary-catheters-in-reducing-catheter-associated-urinary-tract-infection
#4
Alanood Ahmed Aljohi, Hanan Elkefafy Hassan, Rakesh Kumar Gupta
BACKGROUND: Catheter-associated urinary tract infection (CAUTI) is the most common device-related healthcare-acquired infection. CAUTI can be severe and lead to bacteremia, significant morbidity, prolonged hospital stay, and high antibiotic consumption. PATIENTS AND METHODS: In this study, we evaluated the CAUTI-reducing efficacy of noble metal alloy catheters in sixty patients (thirty per group) in the Intensive Care Unit (ICU) at the King Fahad Hospital in Saudi Arabia...
October 2016: Urology Annals
https://www.readbyqxmd.com/read/28052781/inpatient-urine-cultures-are-frequently-performed-without-urinalysis-or-microscopy-findings-from-a-large-academic-medical-center
#5
Abigail L Carlson, Satish Munigala, Anthony J Russo, Kathleen M McMullen, Helen Wood, Ronald Jackups, David K Warren
OBJECTIVE To describe the frequency of urine cultures performed in inpatients without additional testing for pyuria DESIGN Retrospective cohort study SETTING A 1,250-bed academic tertiary referral center PATIENTS Hospitalized adults METHODS This study included urine cultures drawn on 4 medical and 2 surgical wards from 2009 to 2013 and in the medical and surgical intensive care units (ICUs) from 2012 to 2013. Patient and laboratory data were abstracted from the hospital's medical informatics database. We identified catheter-associated urinary tract infections (CAUTIs) in the ICUs by routine infection prevention surveillance...
January 5, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28033847/impact-of-polymicrobial-biofilms-in-catheter-associated-urinary-tract-infections
#6
Andreia S Azevedo, Carina Almeida, Luís F Melo, Nuno F Azevedo
Recent reports have demonstrated that most biofilms involved in catheter-associated urinary tract infections are polymicrobial communities, with pathogenic microorganisms (e.g. Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae) and uncommon microorganisms (e.g. Delftia tsuruhatensis, Achromobacter xylosoxidans) frequently co-inhabiting the same urinary catheter. However, little is known about the interactions that occur between different microorganisms and how they impact biofilm formation and infection outcome...
December 30, 2016: Critical Reviews in Microbiology
https://www.readbyqxmd.com/read/28031194/azithromycin-ciprofloxacin-impregnated-urinary-catheters-avert-bacterial-colonization-biofilm-formation-and-inflammation-in-a-murine-model-of-foreign-body-associated-urinary-tract-infections-caused-by-pseudomonas-aeruginosa
#7
Hina Saini, Anitha Vadekeetil, Sanjay Chhibber, Kusum Harjai
Pseudomonas aeruginosa is a multifaceted pathogen causing a variety of biofilm-mediated infections including catheter-associated urinary tract infections (CAUTIs). High prevalence of CAUTIs in hospitals, their clinical manifestations like urethritis, cystitis, pyelonephritis, meningitis, urosepsis, death; and economic challenges underscore the need for management of these infections. Biomaterial modification of urinary catheters with dual drugs seems an interesting approach to combat CAUTIs by inhibiting biofilm...
December 28, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28025951/optimizing-inpatient-urine-culture-ordering-practices-using-the-electronic-medical-record-a-pilot-study
#8
Daniel Shirley, Harry Scholtz, Kurt Osterby, Jackson Musuuza, Barry Fox, Nasia Safdar
A prospective quasi-experimental before-and-after study of an electronic medical record-anchored intervention of embedded education on appropriate urine culture indications and indication selection reduced the number of urine cultures ordered for catheterized patients at an academic medical center. This intervention could be a component of CAUTI-reduction bundles. Infect Control Hosp Epidemiol 2016;1-3.
December 27, 2016: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28001383/luminescent-lanthanide-cyclen-based-enzymatic-assay-capable-of-diagnosing-the-onset-of-catheter-associated-urinary-tract-infections-both-in-solution-and-within-polymeric-hydrogels
#9
Esther M Surender, Samuel J Bradberry, Sandra A Bright, Colin P McCoy, D Clive Williams, Thorfinnur Gunnlaugsson
Herein we present a supramolecular (delayed luminescent) Eu(III)-based pH-responsive probe/sensor with the ability to detect the urease-mediated hydrolysis of urea in aqueous solution. A series of photophysical titrations show this Eu(III) chelate behaves as an "on-off" luminescent switching probe, with its luminescence being quenched upon urea being enzymatically converted into ammonia and carbon dioxide. Calculation of the rate constant (k) and activation energy (Ea) for this hydrolysis reaction are detailed; the results demonstrate a direct observation of enzymatic activity in solution by the sensor...
December 21, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27987067/prophylactic-antibiotic-treatment-following-laparoscopic-robot-assisted-radical-prostatectomy-for-the-prevention-of-catheter-associated-urinary-tract-infections-did-the-aua-guidelines-make-a-difference
#10
Miki Haifler, Yoram Mor, Zohar Dotan, Jacob Ramon, Dorit E Zilberman
We sought to evaluate the effectiveness of the American Urological Association (AUA) antibiotic prophylaxis guidelines in patients undergoing robot-assisted laparoscopic radical prostatectomy (RALP). Our prospective registry database was reviewed for all RALP cases. The following variables were evaluated: age, associated comorbidities, body mass index (BMI), total operative time, length of stay (LOS), prostate weight, pathological grade and stage. Until 11/2011, RALP patients were treated with antibiotics administered in the operating room and continued until urethral catheter removal...
December 16, 2016: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/27986361/systematic-review-and-meta-analysis-of-the-effectiveness-of-antiseptic-agents-for-meatal-cleaning-in-the-prevention-of-catheter-associated-urinary-tract-infections
#11
REVIEW
O Fasugba, J Koerner, B G Mitchell, A Gardner
BACKGROUND: Catheter-associated urinary tract infections (CAUTIs) are among the most common healthcare-associated infections. Antiseptic cleaning of the meatal area before and during catheter use may reduce the risk of CAUTIs. AIM: To undertake a systematic review of the literature and meta-analysis of studies investigating the effectiveness of antiseptic cleaning before urinary catheter insertion and during catheter use for prevention of CAUTIs. METHODS: Electronic databases were searched to identify randomized controlled trials...
November 4, 2016: Journal of Hospital Infection
https://www.readbyqxmd.com/read/27919427/-lose-the-tube-a-choosing-wisely-initiative-to-reduce-catheter-associated-urinary-tract-infections-in-hospitalist-led-inpatient-units
#12
Hyung J Cho, Steve Khalil, Jashvant Poeran, Madhu Mazumdar, Nathaniel Bravo, Fran Wallach, Brian Markoff, Nathan Lee, Andrew S Dunn
We developed a multidisciplinary initiative, "Lose the Tube," focused on a Choosing Wisely recommendation to decrease catheter-associated urinary tract infection (CAUTI) rates and catheter days. Through an electronic health record catheter identification tool, daily interdisciplinary query, and clinician education, our multifaceted intervention reduced mean per-person catheter days from 3.3 to 2.9, decreased CAUTI rates from 2.85 to 0.32 per 1,000 catheter days, and reduced cost by $32,245.
December 2, 2016: American Journal of Infection Control
https://www.readbyqxmd.com/read/27917728/comparing-catheter-associated-urinary-tract-infection-prevention-programs-between-veterans-affairs-nursing-homes-and-non-veterans-affairs-nursing-homes
#13
Lona Mody, M Todd Greene, Sanjay Saint, Jennifer Meddings, Barbara W Trautner, Heidi L Wald, Christopher Crnich, Jane Banaszak-Holl, Sara E McNamara, Beth J King, Robert Hogikyan, Barbara S Edson, Sarah L Krein
OBJECTIVE The impact of healthcare system integration on infection prevention programs is unknown. Using catheter-associated urinary tract infection (CAUTI) prevention as an example, we hypothesize that US Department of Veterans Affairs (VA) nursing homes have a more robust infection prevention infrastructure due to integration and centralization compared with non-VA nursing homes. SETTING VA and non-VA nursing homes participating in the AHRQ Safety Program for Long-Term Care collaborative. METHODS Nursing homes provided baseline information about their infection prevention programs to assess strengths and gaps related to CAUTI prevention via a needs assessment questionnaire...
December 5, 2016: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/27914268/anti-adhesive-antimicrobial-peptide-coating-prevents-catheter-associated-infection-in-a-mouse-urinary-infection-model
#14
Kai Yu, Joey C Y Lo, Mei Yan, Xiaoqiang Yang, Donald E Brooks, Robert E W Hancock, Dirk Lange, Jayachandran N Kizhakkedathu
Catheter-associated urinary tract infections (CAUTIs) represent one of the most common hospital acquired infections with significant economic consequences and increased patient morbidity. CAUTIs often start with pathogen adhesion and colonization on the catheter surface followed by biofilm formation. Current strategies to prevent CAUTIs are insufficiently effective and antimicrobial coatings based on antimicrobial peptides (AMPs) hold promise in curbing CAUTIs. Here we report an effective surface tethering strategy to prepare AMP coatings on polyurethane (PU), a common biomedical plastic used for catheter manufacture, by using an anti-adhesive hydrophilic polymer coating...
February 2017: Biomaterials
https://www.readbyqxmd.com/read/27895127/the-pathogenic-potential-of-proteus-mirabilis-is-enhanced-by-other-uropathogens-during-polymicrobial-urinary-tract-infection
#15
Chelsie E Armbruster, Sara N Smith, Alexandra O Johnson, Valerie DeOrnellas, Kathryn A Eaton, Alejandra Yep, Lona Mody, Weisheng Wu, Harry L T Mobley
Urinary catheter use is prevalent in health care settings, and polymicrobial colonization by urease-positive organisms, such as Proteus mirabilis and Providencia stuartii, commonly occurs with long-term catheterization. We previously demonstrated that coinfection with P. mirabilis and P. stuartii increased overall urease activity in vitro and disease severity in a model of urinary tract infection (UTI). In this study, we expanded these findings to a murine model of catheter-associated UTI (CAUTI), delineated the contribution of enhanced urease activity to coinfection pathogenesis, and screened for enhanced urease activity with other common CAUTI pathogens...
November 28, 2016: Infection and Immunity
https://www.readbyqxmd.com/read/27881213/impact-and-limitations-of-the-2015-national-health-and-safety-network-case-definition-on-catheter-associated-urinary-tract-infection-rates
#16
Ana Cecilia Bardossy, Rachna Jayaprakash, Anjali C Alangaden, Patricia Starr, Odaliz Abreu-Lanfranco, Katherine Reyes, Marcus J Zervos, George J Alangaden
Application of the new 2015 NHSN definition of catheter-associated urinary tract infection (CAUTI) in intensive care units reduced CAUTI rates by ~50%, primarily due to exclusion of candiduria. This significant reduction in CAUTI rates resulting from the changes in the definition must be considered when evaluating effectiveness of CAUTI prevention programs. Infect Control Hosp Epidemiol 2017;38:239-241.
February 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/27875382/incorporation-of-leadership-rounds-in-cauti-prevention-efforts
#17
Suzanne Purvis, Gregory D Kennedy, Mary Jo Knobloch, Amy Marver, John Marx, Susan Rees, Nasia Safdar, Daniel Shirley
Leadership engagement is an important aspect of integrating best practices at the bedside. The catheter-associated urinary tract infection (CAUTI) prevention workgroup at our academic medical center implemented leadership rounding in partnership with clinical staff to increase participation in CAUTI prevention initiatives on inpatient units. There was an associated decrease in urinary catheter utilization and CAUTI rates. Implementation of leadership rounds should be considered as a part of comprehensive CAUTI prevention efforts in health care settings...
November 21, 2016: Journal of Nursing Care Quality
https://www.readbyqxmd.com/read/27858954/how-often-do-clinically-diagnosed-catheter-associated-urinary-tract-infections-in-nursing-homes-meet-standardized-criteria
#18
Chelsie E Armbruster, Katherine Prenovost, Harry L T Mobley, Lona Mody
OBJECTIVES: To determine the relationship between clinically diagnosed catheter-associated urinary tract infection (CAUTI) and standardized criteria and to assess microorganism-level differences in symptom burden in a cohort of catheterized nursing home (NH) residents. DESIGN: Post hoc analysis of a prospective longitudinal study. SETTING: Twelve NHs in southeast Michigan. PARTICIPANTS: NH residents with indwelling urinary catheters (n = 233; 90% white, 52% male, mean age 73...
November 14, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27852357/a-multifaceted-approach-to-reduction-of-catheter-associated-urinary-tract-infections-in-the-intensive-care-unit-with-an-emphasis-on-stewardship-of-culturing
#19
Katherine M Mullin, Christopher S Kovacs, Cynthia Fatica, Colette Einloth, Elizabeth A Neuner, Jorge A Guzman, Eric Kaiser, Venu Menon, Leticia Castillo, Marc J Popovich, Edward M Manno, Steven M Gordon, Thomas G Fraser
BACKGROUND Catheter-associated urinary tract infections (CAUTIs) are among the most common hospital-acquired infections (HAIs). Reducing CAUTI rates has become a major focus of attention due to increasing public health concerns and reimbursement implications. OBJECTIVE To implement and describe a multifaceted intervention to decrease CAUTIs in our ICUs with an emphasis on indications for obtaining a urine culture. METHODS A project team composed of all critical care disciplines was assembled to address an institutional goal of decreasing CAUTIs...
February 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/27850780/1143-reducing-cauti-risk-in-a-pediatric-cardiac-icu-through-implementation-of-a-daily-safety-checklist
#20
Melissa Busovsky-McNeal, Sujata Chakravarti, Michelle Ramirez, Yasir Al-Qaqaa, Diane Reformina, Caitlin Aberle
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
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