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REVIEW
Mohamed Chakkour, Zeinab Hammoud, Solay Farhat, Ali El Roz, Zeinab Ezzeddine, Ghassan Ghssein
Proteus mirabilis is a Gram-negative bacterium with exclusive molecular and biological features. It is a versatile pathogen acclaimed for its distinct urease production, swarming behavior, and rapid multicellular activity. Clinically, P. mirabilis is a frequent pathogen of the human urinary system where it causes urinary tract infections (UTIs) and catheter-associated urinary tract infections (CAUTIs). This review explores the epidemiology, risk factors, clinical manifestations, and treatment of P. mirabilis infections, emphasizing its association with UTIs...
2024: Frontiers in Microbiology
#2
JOURNAL ARTICLE
Waleed Abdulmotalib Mazi, Mylene Bondad, Maryam Althumali, Turki Alzahrani
BACKGROUND: The urinary catheter usually leads to a catheter-associated urinary tract infection (CAUTI) contributing to further morbidity and mortality. There is very limited data on the CAUTI incidence rate in high-dependency units (HDUs) in the Kingdom of Saudi Arabia. The institutional CAUTI incidence rate in HDU was six times higher compared to the United States National Healthcare Safety Network (US-NHSN) in 2021. OBJECTIVE: To reduce 50% CAUTI incidence rate by the end of 2022...
June 2024: Infection prevention in practice
#3
JOURNAL ARTICLE
Jonathan J Molina, Kurt N Kohler, Christopher Gager, Marissa J Andersen, Ellsa Wongso, Elizabeth R Lucas, Andrew Paik, Wei Xu, Deborah L Donahue, Karla Bergeron, Aleksandra Klim, Michael G Caparon, Scott J Hultgren, Alana Desai, Victoria A Ploplis, Matthew J Flick, Francis J Castellino, Ana L Flores-Mireles
Catheter-associated urinary tract infections (CAUTIs) are amongst the most common nosocomial infections worldwide and are difficult to treat partly due to development of multidrug-resistance from CAUTI-related pathogens. Importantly, CAUTI often leads to secondary bloodstream infections and death. A major challenge is to predict when patients will develop CAUTIs and which populations are at-risk for bloodstream infections. Catheter-induced inflammation promotes fibrinogen (Fg) and fibrin accumulation in the bladder which are exploited as a biofilm formation platform by CAUTI pathogens...
March 27, 2024: Nature Communications
#4
JOURNAL ARTICLE
Abdel Hadi Shmoury, Wael Hanna, Johnny Zakhour, Nada Kara Zahreddine, Souha S Kanj
BACKGROUND: Catheter-associated urinary tract infections (CAUTIs) are the most common device-associated healthcare-acquired infections and pose a significant burden on patients and healthcare systems worldwide. However, there is a paucity of data on CAUTI epidemiology and microbiology in the Middle East and North Africa (MENA) region, including Lebanon. METHODS: This 14-year retrospective cohort study was conducted at a tertiary care center in Lebanon. It analyzed data on all adult patients diagnosed with CAUTI between January 2009 and December 2022 in intensive care units (ICUs) and between June 2011 and December 2022 in regular units...
March 22, 2024: Journal of Infection and Public Health
#5
JOURNAL ARTICLE
Madison J Fitzgerald, Melanie M Pearson, Harry L T Mobley
UNLABELLED: A hallmark of Proteus mirabilis infection of the urinary tract is the formation of stones. The ability to induce urinary stone formation requires urease, a nickel metalloenzyme that hydrolyzes urea. This reaction produces ammonia as a byproduct, which can serve as a nitrogen source and weak base that raises the local pH. The resulting alkalinity induces the precipitation of ions to form stones. Transcriptional regulator UreR activates expression of urease genes in a urea-dependent manner...
March 27, 2024: Journal of Bacteriology
#6
JOURNAL ARTICLE
Lauren Fish, Rachael Heathers, Micah Litherland, Molly Jung, Kalvin Yu
OBJECTIVES: Catheter associated urinary tract infections (CAUTI) are a significant cause of morbidity and financial burden to healthcare systems. The aim of this study was to develop and implement a program designed to reduce Foley catheter use days and associated CAUTI rates. METHODS: A retrospective evaluation of a multi-modal program aimed toward reducing Foley catheter use days and associated CAUTI rates across the Indiana University Health (IUH) system was conducted...
March 25, 2024: Hospital Practice (Minneapolis)
#7
JOURNAL ARTICLE
Daniel Marco Paredes-López, R A Robles-Huaynate, Marilu Roxana Soto-Vásquez, Rosa Amelia Perales-Camacho, Siever Miguel Morales-Cauti, Xiomara Beteta-Blas, Uriel Aldava-Pardave
Bioactive plants such as P. aduncum , M. citrifolia , and A. altilis might improve intestinal health as an alternative to antibiotic growth promoters. The objective of this study was to determine the effect of the ethanolic extracts (EEs) of these plants on the intestinal health of broiler chickens. Cobb 500 chickens ( n = 352) were distributed into eight treatments with four replicates and 11 chickens each. T1 received a base diet, and T2 received a base diet with 0.005% zinc bacitracin. T3, T5, and T7 were supplemented with 0...
2024: Frontiers in Veterinary Science
#8
JOURNAL ARTICLE
Stephen P Schmaltz, Beth A Longo, Scott C Williams
BACKGROUND: This study evaluated the relationship between Joint Commission accreditation and health care-associated infections (HAIs) in long-term care hospitals (LTCHs). METHODS: This observational study used Centers for Medicare & Medicaid Services (CMS) LTCH data for the period 2017 to June 2021. The standardized infection ratio (SIR) of three measures used by the Centers for Disease Control and Prevention's National Healthcare Safety Network were used as dependent variables in a random coefficient Poisson regression model (adjusting for CMS region, owner type, and bed size quartile): catheter-associated urinary tract infections (CAUTIs), Clostridioides difficile infections (CDIs), and central line-associated bloodstream infections (CLABSIs) for the periods 2017 to 2019 and July 1, 2020, to June 30, 2021...
February 16, 2024: Joint Commission Journal on Quality and Patient Safety
#9
REVIEW
Zelalem Asmare, Mulat Erkihun, Wagaw Abebe, Agenagnew Ashagre, Tadesse Misganaw, Sefineh Fenta Feleke
BACKGROUND: Catheter-associated urinary tract infections (CAUTIs) account for the majority of device-associated healthcare-acquired infections with significant morbidity and mortality worldwide. In developing countries with limited resources, the burden of CAUTI have substantial burden owing to the lack of well-organized infection prevention and control. Although there are studies in African countries, the magnitude of CAUTI is inconsistent. Therefore this systematic review and meta-analysis aimed to determine the pooled prevalence of CAUTI in Africa and identify the pathogens involved...
March 13, 2024: Infection, Disease & Health
#10
JOURNAL ARTICLE
Timothy L Wiemken, Ruth M Carrico
BACKGROUND: Health care-associated infection (HAI) surveillance is vital for safety in health care settings. It helps identify infection risk factors, enhancing patient safety and quality improvement. However, HAI surveillance is complex, demanding specialized knowledge and resources. This study investigates the use of artificial intelligence (AI), particularly generative large language models, to improve HAI surveillance. METHODS: We assessed 2 AI agents, OpenAI's chatGPT plus (GPT-4) and a Mixtral 8×7b-based local model, for their ability to identify Central Line-Associated Bloodstream Infection (CLABSI) and Catheter-Associated Urinary Tract Infection (CAUTI) from 6 National Health Care Safety Network training scenarios...
February 29, 2024: American Journal of Infection Control
#11
JOURNAL ARTICLE
José Medina-Polo, Ana Belén Salamanca-Castro, Yolanda Ramallo-Fariña, Max Mòdol-Vidal, Cristina Valcárcel-Nazco, Clara Armas-Moreno, Lilisbeth Perestelo-Pérez, Lidia García-Pérez, Miguel Ángel García-Bello, Manuel Luque-González, Marta Serrano-Muñoz, Santiago Pérez-García
BACKGROUND: Foley catheters have been subject to limited development in the last few decades. They fulfil their basic function of draining urine from the bladder but cause other associated problems. T-Control is a new silicone Foley catheter with an integrated fluid control valve whose design aims to reduce the risks associated with bladder catheterization by a multifactorial approach. The general purpose of this study is to determine the effectiveness, comfort, and experience of the patient catheterized with T-Control® compared with patients with a conventional Foley catheter...
March 2024: BJUI compass
#12
JOURNAL ARTICLE
Ghazala Q Sharieff, Craig Uejo
GOAL: Patient safety and quality care are two critical areas that every healthcare organization strives to grow and improve upon. At Scripps Health, specific efforts reviewed for this article were implemented to reduce hospital-acquired conditions and hospital readmissions that are components of Centers for Medicare & Medicaid Services programs and Leapfrog Hospital Survey scores. METHODS: Sprint teams, a novel approach to rapidly develop a checklist for lower-performing care improvement areas, were implemented after an internal review of existing tools and an evidence-based literature review...
March 2024: Journal of Healthcare Management / American College of Healthcare Executives
#13
JOURNAL ARTICLE
Muhammad A Perdana, Dian D Wahyuni, Rina Yunita
Catheter-associated urinary tract infection (CAUTI) is defined as a urinary tract infection associated with catheter placement for more than two consecutive days. Hence, antibiotic resistance in the context of CAUTIs represents a substantial challenge. The aim of this study was to present the characteristics of patients with CAUTI and the susceptibility pattern of CAUTI bacteria in the national reference hospital of the Sumatra region of Indonesia. A cross-sectional study was conducted at H. Adam Malik General Hospital, Medan, Indonesia, from 2020 to 2021, using a total sampling...
December 2023: Narra J
#14
JOURNAL ARTICLE
Victor Daniel Rosenthal, Ruijie Yin, Zhilin Jin, Valentina Perez, Matthew Adam Kis, Safaa Abdulaziz-Alkhawaja, Sandra Liliana Valderrama-Beltran, R N Katherine Gomez, Claudia Milena Henao Rodas, Amal El-Sisi, Suneeta Sahu, Mohit Kharbanda, Camilla Rodrigues, Sheila Nainan Myatra, Rajesh Chawla, Kavita Sandhu, Yatin Mehta, Prasad Rajhans, Rajalakshmi Arjun, Chian-Wern Tai, Arpita Bhakta, Mohd-Basri Mat Nor, Guadalupe Aguirre-Avalos, Alejandro Sassoe-Gonzalez, Ider Bat-Erdene, Subhash P Acharya, Daisy Aguilar-de-Moros, Nilton Yhuri Carreazo, Wieslawa Duszynska, Sona Hlinkova, Dincer Yildizdas, Esra Kaya Kılıc, Oguz Dursun, Caglar Odek, Suna Secil Ozturk Deniz, Ertugrul Guclu, Iftihar Koksal, Eduardo Alexandrino Medeiros, Michael M Petrov, Lili Tao, Estuardo Salgado, Lourdes Dueñas, Mohammad Abdellatif Daboor, Lul Raka, Abeer Aly Omar, Aamer Ikram, George Horhat-Florin, Ziad A Memish, Eric Christopher Brown
BACKGROUND: Catheter-Associated Urinary Tract Infections (CAUTIs) frequently occur in the ICU and are correlated with a significant burden. METHODS: We implemented a strategy involving a 9-element bundle, education, surveillance of CAUTI rates and clinical outcomes, monitoring compliance with bundle components, feedback of CAUTI rates and performance feedback. This was executed in 299 ICUs across 32 low- and middle-income countries (LMICs). The dependent variable was CAUTI per 1,000-UC-days, assessed at baseline and throughout the intervention, in the 2nd month, 3rd month, 4-15 months, 16-27 months, and 28-39 months...
March 2, 2024: American Journal of Infection Control
#15
JOURNAL ARTICLE
Alfredo J Mena Lora, Jessica Hua, Mirza Ali, Candice Krill, Eden Takhsh, Susan C Bleasdale
Cultures from urinary catheters are often ordered without indication, leading to possible misdiagnosis of catheter-associated urinary tract infections (CAUTI), increasing antimicrobial use, and C difficile . We implemented a diagnostic stewardship intervention for urine cultures from catheters in a community hospital that led to a reduction in cultures and CAUTIs.
2024: Antimicrob Steward Healthc Epidemiol
#16
JOURNAL ARTICLE
Timothy Kelly, ChinEn Ai, Molly Jung, Kalvin Yu
OBJECTIVE: To describe the relative burden of catheter-associated urinary tract infections (CAUTIs) and non-CAUTI hospital-onset urinary tract infections (HOUTIs). METHODS: A retrospective observational study of patients from 43 acute-care hospitals was conducted. CAUTI cases were defined as those reported to the National Healthcare Safety Network. Non-CAUTI HOUTI was defined as a positive, non-contaminated, non-commensal culture collected on day 3 or later. All HOUTIs were required to have a new antimicrobial prescribed within 2 days of the first positive urine culture...
February 20, 2024: Infection Control and Hospital Epidemiology
#17
JOURNAL ARTICLE
Divya Rakesh Joshi, Ram Gopalakrishnan, C Selvi, Nandini Sethuraman, V R Yamunadevi, V Ramasubramanian, P Senthur Nambi, M Yogesh, Thangaraj Paul Ramesh
BACKGROUND: There is a scarcity of data regarding nosocomial infections in patients with COVID-19 treated with ECMO. This observational study from India aims to describe the epidemiology and microbiology of infections in patients with COVID-19 associated ECMO. METHODS: This is an ambi-directional observational study of COVID-19 ECMO patients admitted from April 2021 to June 2022 in a tertiary care hospital. The total number of sepsis episodes for each patient was recorded and were categorized as bloodstream infections (BSI), pneumonias, skin and soft tissue infections (SSTI), invasive candidiasis (IC), catheter associated urinary tract infection (CAUTI), intra-abdominal infections (IAI), and Clostridioides difficile infections...
February 12, 2024: Indian Journal of Medical Microbiology
#18
JOURNAL ARTICLE
Kyla A Clasie, Aniruddh V Deshpande, Andrew Ja Holland, Ashish V Jiwane, Vanessa G Da Silva, Fiona A Filtness, Margaret M Allen, Grahame Hh Smith
BACKGROUND: Hospital acquired urinary tract infections (UTIs) have a detrimental effect on patients, families and hospital resources. The Sydney Children's Hospital Network (SCHN) participates in the National Surgical Quality Improvement Program - Pediatric (NSQIP-P) to monitor post operative complications. NSQIP-P data revealed that the median UTI rate at SCHN was 1.75% in 2019, 3.5 times higher than the NSQIP-P target rate of 0.5%. Over three quarters of the NSQIP-P identified UTI cases also had a urinary catheterization performed intra-operatively...
February 12, 2024: Journal of the American College of Surgeons
#19
JOURNAL ARTICLE
Aria Aminzadeh, Luuk Hilgers, Peter Paul Platenburg, Mickaël Riou, Noémie Perrot, Christelle Rossignol, Axel Cauty, Céline Barc, René Jørgensen
Clostridioides difficile infection (CDI) is a serious healthcare-associated disease, causing symptoms such as diarrhea and pseudomembranous colitis. The major virulence factors responsible for the disease symptoms are two secreted cytotoxic proteins, TcdA and TcdB. A parenteral vaccine based on formaldehyde-inactivated TcdA and TcdB supplemented with alum adjuvant, has previously been investigated in humans but resulted in an insufficient immune response. In search for an improved response, we investigated a novel toxin inactivation method and a novel, potent adjuvant...
February 8, 2024: Vaccine
#20
Sahrudh Dharanendra, Aaron S Gillet, Bashir Geer, Mary Ann Kirkconnell Hall, Patricia R Hwang
Aeromonas species can cause acute gastroenteritis but are much less commonly observed in the hospital setting than other bacteria. Most cases of Aeromonas hydrophila gastroenteritis reported in the literature have occurred in pediatric, elderly, and/or immunocompromised patients. We present a case of subacute watery diarrhea due to A. hydrophila infection in an otherwise healthy 48-year-old female patient with prior abdominal surgeries and recent hospitalization for a catheter-associated urinary tract infection (CAUTI) for which she received antibiotics...
January 2024: Curēus
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