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https://www.readbyqxmd.com/read/27924730/congenital-malformations-attributed-to-prenatal-exposure-to-cyclophosphamide
#1
Padmanabhan Rengasamy
Cyclophosphamide (CPA) remains one of the most widely prescribed anticancer drugs. It is also used in the treatment of rheumatoid arthritis, childhood nephrotic syndrome and systemic lupus erythematosus. It is a potent immunosuppressive agent. It is commonly used in blood and bone marrow transplantation. With the growing trend among women postponing childbearing, the number of women who are diagnosed with breast cancer is also increasing thus escalating the chances of exposure of the unborn child to antineoplastic drugs...
December 6, 2016: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/27924639/similar-developmental-fluctuations-of-hepato-renal-xanthine-oxidoreductase-gene-expression-and-xanthine-oxidase-activity-in-layer-and-broiler-chicken-embryos
#2
D Naseri, K Asasi, I Karimi
1. Xanthine oxidase (XO) has many physiological functions associated with the synthesis of both antioxidant (uric acid: UA) and numerous oxidants (e.g., H2O2), which makes it an important regulator of the cellular redox potential involving organogenesis. The ontogenetic study of hepatic and renal XO makes a better understanding of the putative role of this enzyme in the development of these tissues. 2. Developmental changes of gene expression of xanthine oxidoreductase (XOR), XO activity and UA content of liver and kidney tissues in both broiler and layer chicken embryos were examined during incubation d 14 to 21...
December 7, 2016: British Poultry Science
https://www.readbyqxmd.com/read/27921294/temporal-dissociation-of-developmental-events-in-the-chick-eye-under-low-temperature-conditions
#3
Hideaki Iida, Tiantian Yang, Sadao Yasugi, Yasuo Ishii
The chick embryonic eye is an excellent model for the study of vertebrate organogenesis. Key events in eye development involve thickening, invagination and cytodifferentiation of the lens primordium. While these events occur successively at different developmental stages, the extent to which these events are temporally related is largely unknown. Here we show that the lens invagination is highly sensitive to temperature. Lowering of incubation temperature to 29°C at embryonic day 2 delayed the onset of invagination of the lens, but not thickening and cytodifferentiation, leading to abnormal protrusion of the eye...
December 6, 2016: Development, Growth & Differentiation
https://www.readbyqxmd.com/read/27912840/the-semaphorins-and-their-receptors-as-modulators-of-tumor-progression
#4
Gera Neufeld, Yelena Mumblat, Tanya Smolkin, Shira Toledano, Inbal Nir-Zvi, Keren Ziv, Ofra Kessler
The semaphorins were initially characterized as repulsive axon guidance factors. However, they are currently also recognized as important regulators of diverse biological processes which include regulation of immune responses, angiogenesis, organogenesis, and a variety of additional physiological and developmental functions. The semaphorin family consists of more than 20 genes divided into seven subfamilies, all of which contain the sema domain signature. They usually transduce signals by activation of receptors belonging to the plexin family, either directly, or indirectly following the binding of some semaphorins to receptors of the neuropilin family which subsequently associate with plexins...
November 2016: Drug Resistance Updates: Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy
https://www.readbyqxmd.com/read/27911332/type-0-spinal-muscular-atrophy-further%C3%A2-delineation-of-prenatal-and%C3%A2-postnatal-features-in-16-patients
#5
Sarah Grotto, Jean-Marie Cuisset, Stéphane Marret, Séverine Drunat, Patricia Faure, Séverine Audebert-Bellanger, Isabelle Desguerre, Vincent Flurin, Anne-Gaëlle Grebille, Anne-Marie Guerrot, Hubert Journel, Gilles Morin, Ghislaine Plessis, Sylvain Renolleau, Joëlle Roume, Brigitte Simon-Bouy, Renaud Touraine, Marjolaine Willems, Thierry Frébourg, Eric Verspyck, Pascale Saugier-Veber
BACKGROUND: Spinal muscular atrophy (SMA) is caused by homozygous inactivation of the SMN1 gene. The SMN2 copy number modulates the severity of SMA. The 0SMN1/1SMN2 genotype, the most severe genotype compatible with life, is expected to be associated with the most severe form of the disease, called type 0 SMA, defined by prenatal onset. OBJECTIVE: The aim of the study was to review clinical features and prenatal manifestations in this rare SMA subtype. METHODS: SMA patients with the 0SMN1/1SMN2 genotype were retrospectively collected using the UMD-SMN1 France database...
November 29, 2016: Journal of Neuromuscular Diseases
https://www.readbyqxmd.com/read/27894513/complement-in-the-fundamental-processes-of-the-cell
#6
Owen A Hawksworth, Liam G Coulthard, Trent M Woodruff
Once regarded solely as an activator of innate immunity, it is now clear that the complement system acts in an assortment of cells and tissues, with immunity only one facet of a diverse array of functions under the influence of the complement proteins. Throughout development, complement activity has now been demonstrated from early sperm-egg interactions in fertilisation, to regulation of epiboly and organogenesis, and later in refinement of cerebral synapses. Complement has also been shown to regulate homeostasis of adult tissues, controlling cell processes such as migration, survival, repair, and regeneration...
November 25, 2016: Molecular Immunology
https://www.readbyqxmd.com/read/27892540/pancreatic-mesenchyme-regulates-islet-cellular-composition-in-a-patched-hedgehog-dependent-manner
#7
Daniel Hibsher, Alona Epshtein, Nufar Oren, Limor Landsman
Pancreas development requires restrained Hedgehog (Hh) signaling activation. While deregulated Hh signaling in the pancreatic mesenchyme has been long suggested to be detrimental for proper organogenesis, this association was not directly shown. Here, we analyzed the contribution of mesenchymal Hh signaling to pancreas development. To increase Hh signaling in the pancreatic mesenchyme of mouse embryos, we deleted Patched1 (Ptch1) in these cells. Our findings indicate that deregulated Hh signaling in mesenchymal cells was sufficient to impair pancreas development, affecting both endocrine and exocrine cells...
November 28, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27888193/conserved-and-novel-functions-of-programmed-cellular-senescence-during-vertebrate-development
#8
Hongorzul Davaapil, Jeremy P Brockes, Maximina H Yun
Cellular senescence, a form of stable cell cycle arrest traditionally associated with tumour suppression, has been recently found to occur during mammalian development. Here, we show that cell senescence is an intrinsic part of the developmental programme in amphibians. Programmed senescence occurs in specific structures at defined time-windows during amphibian development. It contributes to the physiological degeneration of the amphibian pronephros and to the development of the cement gland and oral cavity...
November 25, 2016: Development
https://www.readbyqxmd.com/read/27884048/microrna-142-is-a-multifaceted-regulator-in-organogenesis-homeostasis-and-disease
#9
REVIEW
A Shrestha, R T Mukhametshina, S Taghizadeh, E Vásquez-Pacheco, H Cabrera-Fuentes, A Rizvanov, B Mari, G Carraro, S Bellusci
Over the last decade, microRNA-142 (miR-142) is emerging as a major regulator of cell fate decision in the hematopoietic system. However, miR-142 is expressed in many other tissues and recent evidence suggest that it may play a more pleiotropic role during embryonic development. In addition, miR-142 has been shown to play important functions in disease. miR-142 displays a functional role in cancer, virus infection, inflammation and immune tolerance. Both a guide strand (miR-142-3p) and passenger strand (miR-142-5p) are generated from the miR-142 hairpin...
November 24, 2016: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/27883217/nitric-oxide-is-involved-in-methane-induced-adventitious-root-formation-in-cucumber
#10
Fang Qi, Zhixin Xiang, Ninghai Kou, Weiti Cui, Daokun Xu, Ren Wang, Dan Zhu, Wenbiao Shen
Our previous studies revealed that methane (CH4 ) induces adventitious rooting in cucumber. However, the corresponding molecular mechanism is still elusive. In this work, we discovered that CH4 triggered the accumulation of nitric oxide (NO) and thereafter cucumber adventitious rooting, mimicking the inducing effects of sodium nitroprusside (SNP) and NONOate (two NO-releasing compounds). Above mentioned responses were sensitive to NO scavenger(s), showing that the accumulation of NO and adventitious root development were respectively impaired...
November 24, 2016: Physiologia Plantarum
https://www.readbyqxmd.com/read/27878992/fusca3-interacting-with-leafy-cotyledon2-controls-lateral-root-formation-through-regulating-yucca4-gene-expression-in-arabidopsis-thaliana
#11
Li Ping Tang, Chao Zhou, Shan Shan Wang, Jia Yuan, Xian Sheng Zhang, Ying Hua Su
Lateral root (LR) development is a post-embryonic organogenesis event that gives rise to most of the underground parts of higher plants. Auxin promotes LR formation, but the molecular mechanisms involved in this process are still not well understood. We analyzed LR formation induced by FUSCA3 (FUS3), a B3 domain transcription factor, which may function by promoting auxin biosynthesis during this process. We identified FUS3-interacting proteins that function in LR formation. In addition, we searched for the common targets of both FUS3 and its interacting protein...
November 23, 2016: New Phytologist
https://www.readbyqxmd.com/read/27873560/embryonic-development-in-zungaro-jahu
#12
Camila Marques, Francine Faustino, Bruno Bertolucci, Maria do Carmo Faria Paes, Regiane Cristina da Silva, Laura Satiko Okada Nakaghi
The aim of this study was to characterize the embryonic development of Zungaro jahu, a fresh water teleostei commonly known as 'jaú'. Samples were collected at pre-determined times from oocyte release to larval hatching and analysed under light microscopy, transmission electron microscopy and scanning electron microscopy. At the first collection times, the oocytes and eggs were spherical and yellowish, with an evident micropyle. Embryo development took place at 29.4 ± 1.5°C and was divided into seven stages: zygote, cleavage, morula, blastula, gastrula, organogenesis, and hatching...
November 22, 2016: Zygote: the Biology of Gametes and Early Embryos
https://www.readbyqxmd.com/read/27872633/a-factor-linking-floral-organ-identity-and-growth-revealed-by-characterization-of-the-tomato-mutant-unfinished-flower-development-ufd
#13
Sandra Poyatos-Pertíñez, Muriel Quinet, Ana Ortíz-Atienza, Fernando J Yuste-Lisbona, Clara Pons, Estela Giménez, Trinidad Angosto, Antonio Granell, Juan Capel, Rafael Lozano
Floral organogenesis requires coordinated interactions between genes specifying floral organ identity and those regulating growth and size of developing floral organs. With the aim to isolate regulatory genes linking both developmental processes (i.e., floral organ identity and growth) in the tomato model species, a novel mutant altered in the formation of floral organs was further characterized. Under normal growth conditions, floral organ primordia of mutant plants were correctly initiated, however, they were unable to complete their development impeding the formation of mature and fertile flowers...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27869716/a-genome-wide-identification-and-analysis-of-the-basic-helix-loop-helix-transcription-factors-in-brown-planthopper-nilaparvata-lugens
#14
Pin-Jun Wan, San-Yue Yuan, Wei-Xia Wang, Xu Chen, Feng-Xiang Lai, Qiang Fu
The basic helix-loop-helix (bHLH) transcription factors in insects play essential roles in multiple developmental processes including neurogenesis, sterol metabolism, circadian rhythms, organogenesis and formation of olfactory sensory neurons. The identification and function analysis of bHLH family members of the most destructive insect pest of rice, Nilaparvata lugens, may provide novel tools for pest management. Here, a genome-wide survey for bHLH sequences identified 60 bHLH sequences (NlbHLHs) encoded in the draft genome of N...
November 18, 2016: Genes
https://www.readbyqxmd.com/read/27864511/root-nodule-symbiosis-in-lotus-japonicus-drives-the-establishment-of-distinctive-rhizosphere-root-and-nodule-bacterial-communities
#15
Rafal Zgadzaj, Ruben Garrido-Oter, Dorthe Bodker Jensen, Anna Koprivova, Paul Schulze-Lefert, Simona Radutoiu
Lotus japonicus has been used for decades as a model legume to study the establishment of binary symbiotic relationships with nitrogen-fixing rhizobia that trigger root nodule organogenesis for bacterial accommodation. Using community profiling of 16S rRNA gene amplicons, we reveal that in Lotus, distinctive nodule- and root-inhabiting communities are established by parallel, rather than consecutive, selection of bacteria from the rhizosphere and root compartments. Comparative analyses of wild-type (WT) and symbiotic mutants in Nod factor receptor5 (nfr5), Nodule inception (nin) and Lotus histidine kinase1 (lhk1) genes identified a previously unsuspected role of the nodulation pathway in the establishment of different bacterial assemblages in the root and rhizosphere...
November 18, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27863467/microarray-analysis-reveals-a-potential-role-of-lncrnas-expression-in-cardiac-cell-proliferation
#16
Jue Wang, Zhimin Geng, Jiakan Weng, Longjie Shen, Ming Li, Xueli Cai, Chengchao Sun, Maoping Chu
BACKGROUND: Long non-coding RNAs (LncRNAs) have been identified to play important roles in epigenetic processes that underpin organogenesis. However, the role of LncRNAs in the regulation of transition from fetal to adult life of human heart has not been evaluated. METHODS: Immunofiuorescent staining was used to determine the extent of cardiac cell proliferation. Human LncRNA microarrays were applied to define gene expression signatures of the fetal (13-17 weeks of gestation, n = 4) and adult hearts (30-40 years old, n = 4)...
November 18, 2016: BMC Developmental Biology
https://www.readbyqxmd.com/read/27861793/a-novel-foxn1-egfp-mouse-model-identifies-bmp4-induced-maintenance-of-foxn1-expression-and-thymic-epithelial-progenitor-populations
#17
Marco Barsanti, Joanna M C Lim, Michael L Hun, Natalie Lister, Kahlia Wong, Maree V Hammett, Ailin Lepletier, Richard L Boyd, Antonietta Giudice, Ann P Chidgey
Although forkhead-box n1 (Foxn1) is a critical thymic epithelial cell regulator in thymus organogenesis, its association with epithelial differentiation and homeostasis in the postnatal and aged thymic microenvironment remains conflicting. Consequently, we have generated a Foxn1(eGFP/+) knock-in mouse model that allows for refined investigation of the aging thymic epithelium. This reporter line differs from those previously published in that concomitant expression of enhanced green fluorescent protein enables live cell sorting of Foxn1(+) cell populations...
November 10, 2016: European Journal of Immunology
https://www.readbyqxmd.com/read/27861562/digitor-dasciz-has-multiple-roles-in-drosophila-development
#18
Saheli Sengupta, Uttama Rath, Changfu Yao, Michael Zavortink, Chao Wang, Jack Girton, Kristen M Johansen, Jørgen Johansen
In this study we provide evidence that the spindle matrix protein Skeletor in Drosophila interacts with the human ASCIZ (also known as ATMIN and ZNF822) ortholog, Digitor/dASCIZ. This interaction was first detected in a yeast two-hybrid screen and subsequently confirmed by pull-down assays. We also confirm a previously documented function of Digitor/dASCIZ as a regulator of Dynein light chain/Cut up expression. Using transgenic expression of a mCitrine-labeled Digitor construct, we show that Digitor/dASCIZ is a nuclear protein that is localized to interband and developmental puff chromosomal regions during interphase but redistributes to the spindle region during mitosis...
2016: PloS One
https://www.readbyqxmd.com/read/27852218/rna-seq-based-transcriptomic-map-reveals-new-insights-into-mouse-salivary-gland-development-and-maturation
#19
Christian Gluck, Sangwon Min, Akinsola Oyelakin, Kirsten Smalley, Satrajit Sinha, Rose-Anne Romano
BACKGROUND: Mouse models have served a valuable role in deciphering various facets of Salivary Gland (SG) biology, from normal developmental programs to diseased states. To facilitate such studies, gene expression profiling maps have been generated for various stages of SG organogenesis. However these prior studies fall short of capturing the transcriptional complexity due to the limited scope of gene-centric microarray-based technology. Compared to microarray, RNA-sequencing (RNA-seq) offers unbiased detection of novel transcripts, broader dynamic range and high specificity and sensitivity for detection of genes, transcripts, and differential gene expression...
November 16, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27852061/thyroid-transcription-factor-foxe1-interacts-with-ets-factor-elk1-to-co-regulate-tert
#20
Martyn Bullock, Grace Lim, Cheng Li, In Ho Choi, Shivansh Kochhar, Chris Liddle, Lei Zhang, Roderick J Clifton-Bligh
BACKGROUND: Although FOXE1 was initially recognized for its role in thyroid organogenesis, more recently a strong association has been identified between the FOXE1 locus and thyroid cancer. The role of FOXE1 in adult thyroid, and in particular regarding cancer risk, has not been well established. We hypothesised that discovering key FOXE1 transcriptional partners would in turn identify regulatory pathways relevant to its role in oncogenesis. RESULTS: In a transcription factor-binding array, ELK1 was identified to bind FOXE1...
November 11, 2016: Oncotarget
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