keyword
https://read.qxmd.com/read/38456228/lncrna-lucat1-promotes-glioblastoma-progression-by-enhancing-hif1%C3%AE-activity
#1
JOURNAL ARTICLE
Haidong Huang, Hariti Shah, Jing Hao, Jianhong Lin, Richard A Prayson, Liangqi Xie, Shideng Bao, Abhishek A Chakraborty, Eckhard Jankowsky, Jianjun Zhao, Jennifer S Yu
BACKGROUND: Hypoxia is associated with poor prognosis in many cancers including glioblastoma (GBM). Glioma stem-like cells (GSCs) often reside in hypoxic regions and serve as reservoirs for disease progression. Long non-coding RNAs (lncRNAs) have been implicated in GBM. However, the lncRNAs that modulate GSC adaptations to hypoxia are poorly understood. Identification of these lncRNAs may provide new therapeutic strategies to target GSCs under hypoxia. METHODS: lncRNAs induced by hypoxia in GSCs were identified by RNAseq...
March 8, 2024: Neuro-oncology
https://read.qxmd.com/read/38422369/long-non-coding-rna-kb-1460a1-5-promotes-ferroptosis-by-inhibiting-mtor-srebp-1-scd1-mediated-polyunsaturated-fatty-acid-desaturation-in-glioma
#2
JOURNAL ARTICLE
Lixia Xu, Binli Wen, Qiaoli Wu, Shan Lu, Jianwen Liao, Lidong Mo, Qingguo Li, Xiaoguang Tong, Hua Yan
Ferroptosis is a new form of regulated cell death caused by the iron-dependent peroxidation of phospholipids and is related to cell metabolism, redox homeostasis and various signalling pathways related to cancer. The long noncoding RNA (lncRNA) KB-1460A1.5 acts as a tumour suppressor gene to regulate tumour growth in gliomas, but its molecular network regulatory mechanism is still unclear. In this study, we found that KB-1460A1.5 can induce ferroptosis in glioma and enhance sensitivity to RSL3, a ferroptosis inducer...
February 29, 2024: Carcinogenesis
https://read.qxmd.com/read/38376452/identification-and-verification-on-prognostic-index-of-glioblastoma-immune-related-lncrnas
#3
JOURNAL ARTICLE
Guofu Zheng, Qingsong Jiang, Cai Jiang, Xingxin Zhu, Yongjie Wang
BACKGROUND: Glioblastoma (GBM) is the most common cause of primary brain malignancy. Recently, many immune-related long noncoding ribonucleic acids (ir-lncRNAs) are indicated to be closely related to the regulation of the immune microenvironment and immune cell infiltration of GBM. OBJECTIVES: Through the joint analysis of multiple public databases, key ir-lncRNAs in GBM were screened. The ir-lncRNAs were used to construct risk-scoring models and promote the development of novel GBM biomarkers...
February 20, 2024: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/38366205/roles-of-hotair-long-non-coding-rna-in-gliomas-and-other-cns-disorders
#4
REVIEW
Faraz Ahmad, Ravi Sudesh, A Toufeeq Ahmed, Shafiul Haque
HOX transcript antisense intergenic RNA (HOTAIR) is a long non-coding RNA (lncRNA) which is increasingly being perceived as a tremendous molecular mediator of brain pathophysiology at multiple levels. Epigenetic regulation of target gene expression carried out by HOTAIR is thorough modulation of chromatin modifiers; histone methyltransferase polycomb repressive complex 2 (PRC2) and histone demethylase lysine-specific demethylase 1 (LSD1). Incidentally, HOTAIR was the first lncRNA shown to elicit sponging of specific microRNA (miRNA or miR) species in a trans-acting manner...
February 16, 2024: Cellular and Molecular Neurobiology
https://read.qxmd.com/read/38322836/expression-of-lncrnas-in-glioma-a-lighthouse-for-patients-with-glioma
#5
REVIEW
Xiaolin Lu, Dongzhi Zhang
Glioma is the most common malignant tumour in the central nervous system, accounting for approximately 30 % of the primary tumours of this system. The World Health Organization grades for glioma include: Grade I (pilocytic astrocytoma), Grade II (astrocytoma, oligodastoma, etc.), Grade III (anaplastic astrocytoma, anaplastic oligodastoma, etc.) and Grade IV (glioblastoma). With grade increases, the proliferation, invasion and other malignant biological properties of the glioma are enhanced, and the treatment results are less satisfactory...
February 15, 2024: Heliyon
https://read.qxmd.com/read/38258133/biomolecules-to-biomarkers-u87mg-marker-evaluation-on-the-path-towards-glioblastoma-multiforme-pathogenesis
#6
JOURNAL ARTICLE
Markéta Pokorná, Viera Kútna, Saak V Ovsepian, Radoslav Matěj, Marie Černá, Valerie Bríd O'Leary
The heterogeneity of the glioma subtype glioblastoma multiforme (GBM) challenges effective neuropathological treatment. The reliance on in vitro studies and xenografted animal models to simulate human GBM has proven ineffective. Currently, a dearth of knowledge exists regarding the applicability of cell line biomolecules to the realm of GBM pathogenesis. Our study's objectives were to address this preclinical issue and assess prominin-1, ICAM-1, PARTICLE and GAS5 as potential GBM diagnostic targets. The methodologies included haemoxylin and eosin staining, immunofluorescence, in situ hybridization and quantitative PCR...
January 18, 2024: Pharmaceutics
https://read.qxmd.com/read/38244670/long-non-coding-rna-cox10-as1-promotes-glioma-progression-by-competitively-binding-mir-1-3p-to-regulate-orc6-expression
#7
JOURNAL ARTICLE
Ge Zhang, Xiang Tao, Bao-Wei Ji, Jie Gong
Glioma is one of the most common and difficult to cure malignant primary tumors of the central nervous system. Long non-coding RNA (lncRNA) has been reported to play important functions in biological processes of many tumors, including glioma. In our study, we aimed to reveal the role and molecular mechanisms of lncRNA COX10-AS1 in regulating the progression of glioma. First of all, we showed that lncRNA COX10-AS1 was significantly increased in glioma tissues and cell lines, and high-expressed COX10-AS1 was associated with a poor prognosis in glioma patients...
January 18, 2024: Neuroscience
https://read.qxmd.com/read/38235619/lncrna-psmb8-as1-increases-glioma-malignancy-via-the-mir-382-3p-bcat1-axis
#8
JOURNAL ARTICLE
Haibo Liu, Jie Zhang, Jiamin Li, Xiaoying Cao, Kai Yu, Xun Xia, Zongxi Li, Fengbo Wang
BACKGROUND: This study aimed to investigate the specific roles of the long non-coding RNA (lncRNA) proteasome 20S subunit beta 8 (PSMB8)-antisense RNA 1 (AS1)/microRNA (miR)-382-3p/branched-chain amino acid transaminase 1 (BCAT1) interaction network in gliomas. METHODS: Western blotting and quantitative reverse transcription-polymerase chain reaction were performed to assess the expression levels of lncRNA PSMB8-AS1, BCAT1, and miR-382-3p. Moreover, the cell proliferation, migration, and apoptosis were assessed using the cell counting kit-8, Transwell, and caspase-3 activity assays, respectively...
January 2024: Translational Oncology
https://read.qxmd.com/read/38229597/development-of-an-m6a-related-lncrnas-signature-predicts-tumor-stemness-and-prognosis-for-low-grade-glioma-patients
#9
JOURNAL ARTICLE
Dahua Xu, Peihu Li, Chunrui Zhang, Yutong Shen, Jiale Cai, Qingchen Wei, Meng Cao, Zhizhou Xu, Deng Wu, Hong Wang, Xiaoman Bi, Bo Wang, Kongning Li
BACKGROUND: Growing evidence has revealed that m6A modification of long noncoding RNAs (lncRNAs) dynamically controls tumor stemness and tumorigenesis-related processes. However, the prognostic significance of m6A-related lncRNAs and their associations with stemness in low-grade glioma (LGG) remain to be clarified. METHODS: A multicenter transcriptome analysis of lncRNA expression in 1,247 LGG samples was performed in this study. The stemness landscape of LGG tumors was presented and associations with clinical features were revealed...
2024: Stem Cells International
https://read.qxmd.com/read/38193984/m-6-a-mediated-upregulation-of-lncrna-chaserr-promotes-the-progression-of-glioma-by-modulating-the-mir-6893-3p-trim14-axis
#10
JOURNAL ARTICLE
Xingwei Wu, Minjie Fu, Chang Ge, Hanyu Zhou, Haoyu Huang, Min Zhong, Mengying Zhang, Hao Xu, Guoping Zhu, Wei Hua, Kun Lv, Hui Yang
Long noncoding RNAs (lncRNAs) play crucial roles in tumor progression and are dysregulated in glioma. However, the functional roles of lncRNAs in glioma remain largely unknown. In this study, we utilized the TCGA (the Cancer Genome Atlas database) and GEPIA2 (Gene Expression Profiling Interactive Analysis 2) databases and observed the overexpression of lncRNA CHASERR in glioma tissues. We subsequently investigated this phenomenon in glioma cell lines. The effects of lncRNA CHASERR on glioma proliferation, migration, and invasion were analyzed using in vitro and in vivo experiments...
January 9, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38161583/crnde-a-pivotal-oncogenic-long-non-coding-rna-in-cancers
#11
REVIEW
Yi Zhen Hor, Shamala Salvamani, Baskaran Gunasekaran, Koh Rhun Yian
Colorectal Neoplasia Differentially Expressed (CRNDE), a long non-coding RNA that was initially identified as aberrantly expressed in colorectal cancer (CRC) has also been observed to exhibit elevated expression in various other human malignancies. Recent research has accumulated substantial evidence implicating CRNDE as an oncogenic player, exerting influence over critical cellular processes linked to cancer progression. Particularly, its regulatory interactions with microRNAs and proteins have been shown to modulate pathways that contribute to carcinogenesis and tumorigenesis...
December 2023: Yale Journal of Biology and Medicine
https://read.qxmd.com/read/38141017/a-transcription-factor-znf384-regulated-by-linc00265-activates-the-expression-of-ifi30-to-stimulate-malignant-progression-in-glioma
#12
JOURNAL ARTICLE
Jian Yang, Shenghe Yang, Jinlian Cai, Hongjin Chen, Lihua Sun, Jiajia Wang, Guoqiang Hou, Shuo Gu, Jie Ma, Jianwei Ge
Glioma remains one of the most challenging primary brain malignancies to treat. Long noncoding RNAs (lncRNAs) and mRNAs (mRNAs) are implicated in regulating the malignant phenotypes of cancers including glioma. This study aimed to elucidate the functions and mechanisms of lncRNA LINC00265 and mRNA IFI30 in the pathogenesis of glioma. Quantitative real-time polymerase chain reaction (RT-qPCR) analysis revealed the upregulated expression of LINC00265 and IFI30 in glioma cells compared to normal human astrocytes...
December 23, 2023: ACS Chemical Neuroscience
https://read.qxmd.com/read/38116063/identification-of-rp11-770j1-4-as-immune-related-lncrna-regulating-the-ctxn1-cgas-sting-axis-in-histologically-lower-grade-glioma
#13
JOURNAL ARTICLE
Qiyuan Zhuang, Chaxian Liu, Yihan Hu, Ying Liu, Yingying Lyu, Yuheng Liao, Liang Chen, Hui Yang, Ying Mao
Human gliomas are lethal brain cancers. Emerging evidence revealed the regulatory role of long noncoding RNAs (lncRNAs) in tumors. Here, we performed a comprehensive analysis of the expression profiles of RNAs in histologically lower-grade glioma (LGG). Enrichment analysis revealed that glioma is influenced by immune-related signatures. Survival analysis further established the close correlation between network features and glioma prognosis. Subsequent experiments showed lncRNA RP11-770J1.4 regulates CTXN1 expression through hsa-miR-124-3p...
December 2023: MedComm
https://read.qxmd.com/read/38084701/histone-lactylation-derived-linc01127-promotes-the-self-renewal-of-glioblastoma-stem-cells-via-the-cis-regulating-the-map4k4-to-activate-jnk-pathway
#14
JOURNAL ARTICLE
Lulu Li, Ziwei Li, Xiangqi Meng, Xinyu Wang, Dan Song, Yuxiang Liu, Tianye Xu, Jie Qin, Nan Sun, Kaifu Tian, Junzhe Zhong, Daohan Yu, Yu Song, Tianlang Hou, Chuanlu Jiang, Qun Chen, Jinquan Cai
Gliomas are the most prevalent and aggressive brain tumors, exhibiting high proliferation, abnormal glycolysis, and poor prognosis. LncRNAs act as regulatory molecules and play crucial roles in the malignant behaviors of GBM cells, including cell self-renewal. However, the regulatory mechanisms involved are largely unknown. In this study, we performed bioinformatics analysis to explore NF-κB pathway-related lncRNAs. ECAR and qRT-PCR were used to measure the relationship between glycolytic activity and lncRNA expression...
November 28, 2023: Cancer Letters
https://read.qxmd.com/read/38040698/tmem44-as1-promotes-esophageal-squamous-cell-carcinoma-progression-by-regulating-the-igf2bp2-gpx4-axis-in-modulating-ferroptosis
#15
JOURNAL ARTICLE
Ruotong Yang, Junhu Wan, Liwei Ma, Fuyou Zhou, Zhengwu Yang, Zhuofang Li, Mingyuan Zhang, Liang Ming
The long non-coding RNA (lncRNA) TMEM44-AS1 is a novel lncRNA whose pro-carcinogenic role in gastric cancer and glioma has been demonstrated. However, its function in esophageal squamous cell carcinoma (ESCC) is unknown. In this study, we identified that TMEM44-AS1 was highly expressed in ESCC tissues and cells. Functionally, TMEM44-AS1 promoted ESCC cell proliferation, invasion and metastasis in vitro and in vivo. TMEM44-AS1 inhibited ferroptosis in ESCC cells, and ferroptosis levels were significantly increased after knockdown of TMEM44-AS1...
December 1, 2023: Cell Death Discovery
https://read.qxmd.com/read/38022537/construction-and-experimental-validation-of-a-signature-for-predicting-prognosis-and-immune-infiltration-analysis-of-glioma-based-on-disulfidptosis-related-lncrnas
#16
JOURNAL ARTICLE
Youwei Guo, Zhipeng Jiang, Quan Chen, Dongcheng Xie, Yi Zhou, Wen Yin, Zihan Wang, Binbin Wang, Caiping Ren, Xingjun Jiang
BACKGROUNDS: Disulfidptosis, a newly discovered mechanism of programmed cell death, is believed to have a unique role in elucidating cancer progression and guiding cancer therapy strategies. However, no studies have yet explored this mechanism in glioma. METHODS: We downloaded data on glioma patients from online databases to address this gap. Subsequently, we identified disulfidptosis-related genes from published literature and verified the associated lncRNAs. RESULTS: Through univariate, multivariate, and least absolute shrinkage and selection operator (LASSO) regression algorithms analyses, we identified 10 lncRNAs...
2023: Frontiers in Immunology
https://read.qxmd.com/read/38020906/exosomal-non-coding-rnas-in-glioma-progression-insights-into-tumor-microenvironment-dynamics-and-therapeutic-implications
#17
REVIEW
Davide Marangon, Davide Lecca
Gliomas are the most common and deadly types of brain tumors, known for their extensive genetic and epigenetic variability, which poses considerable challenges for pharmacological treatment. Glioma heterogeneity is also related to their intricate and dynamic tumor microenvironment (TME), which comprises a diverse array of cell types, including immune cells, vascular cells, glial cells, and neural precursors, collectively influencing tumor behavior and progression. A pivotal aspect of this intercellular communication relies on the exchange of extracellular vesicles (EVs), which contain and transfer complex molecular cargoes typical of their cells of origin, such as proteins, lipids, carbohydrates, metabolites, and non-coding RNAs (ncRNAs), that encompass microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs)...
2023: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/37980347/lncrna-inheg-promotes-glioma-stem-cell-maintenance-and-tumorigenicity-through-regulating-rrna-2-o-methylation
#18
JOURNAL ARTICLE
Lihui Liu, Ziyang Liu, Qinghua Liu, Wei Wu, Peng Lin, Xing Liu, Yuechuan Zhang, Dongpeng Wang, Briana C Prager, Ryan C Gimple, Jichuan Yu, Weixi Zhao, Qiulian Wu, Wei Zhang, Erzhong Wu, Xiaomin Chen, Jianjun Luo, Jeremy N Rich, Qi Xie, Tao Jiang, Runsheng Chen
Glioblastoma (GBM) ranks among the most lethal of human cancers, containing glioma stem cells (GSCs) that display therapeutic resistance. Here, we report that the lncRNA INHEG is highly expressed in GSCs compared to differentiated glioma cells (DGCs) and promotes GSC self-renewal and tumorigenicity through control of rRNA 2'-O-methylation. INHEG induces the interaction between SUMO2 E3 ligase TAF15 and NOP58, a core component of snoRNP that guides rRNA methylation, to regulate NOP58 sumoylation and accelerate the C/D box snoRNP assembly...
November 18, 2023: Nature Communications
https://read.qxmd.com/read/37950931/exploring-the-role-of-lncrna-neat1-knockdown-in-regulating-apoptosis-across-multiple-cancer-types-a-review
#19
REVIEW
Md Sadique Hussain, Gaurav Gupta, Muhammad Afzal, Safar M Alqahtani, Vijaya Paul Samuel, Waleed Hassan Almalki, Imran Kazmi, Sami I Alzarea, Shakir Saleem, Harish Dureja, Sachin Kumar Singh, Kamal Dua, Lakshmi Thangavelu
Long non-coding RNAs (lncRNAs) have emerged as pivotal regulators of gene expression, contributing significantly to a diverse range of cellular processes, including apoptosis. One such lncRNA is NEAT1, which is elevated in several types of cancer and aid in cancer growth. However, recent studies have also demonstrated that the knockdown of NEAT1 can inhibit cancer cells proliferation, movement, and infiltration while enhancing apoptosis. This article explores the function of lncRNA NEAT1 knockdown in regulating apoptosis across multiple cancer types...
October 31, 2023: Pathology, Research and Practice
https://read.qxmd.com/read/37941063/lncrna-mafg-as1-is-involved-in-human-cancer-progression
#20
REVIEW
Penghui Li, Xiao Ma, Xinyu Gu
Long noncoding RNAs (lncRNAs) refer to a type of non-protein-coding transcript of more than 200 nucleotides. LncRNAs play fundamental roles in disease development and progression, and lncRNAs are dysregulated in many pathophysiological processes. Thus, lncRNAs may have potential value in clinical applications. The lncRNA, MAF BZIP Transcription Factor G (MAFG)-AS1, is dysregulated in several cancer, including breast cancer, lung cancer, liver cancer, bladder cancer, colorectal cancer, gastric cancer, esophagus cancer, prostate cancer, pancreatic cancer, ovarian cancer, and glioma...
November 8, 2023: European Journal of Medical Research
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