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Glioma lncRNA

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https://www.readbyqxmd.com/read/28621230/lncrna-crnde-triggers-inflammation-through-the-tlr3-nf-%C3%AE%C2%BAb-cytokine-signaling-pathway
#1
Haowen Li, Qi Li, Tao Guo, Wenyan He, Chengya Dong, Yajie Wang
Colorectal neoplasia differentially expressed (CRNDE), an oncogene, is highly expressed in many tumor cells and affects cellular proliferation, migration, invasion, and apoptosis. Its function and mechanism of action is a research hotspot. In this study, microarray analysis was performed to discover the differentially expressed genes in CRNDE over-expression cells. RT² Profiler PCR Array was used to study the expression of genes related to the toll-like receptor (TLR) pathway. We found that over-expression of CRNDE in astrocytes increased the expression of key factors in the toll-like receptor signaling pathway, especially toll-like receptor-3-mediated MyD88-independent pathway...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28600863/silencing-of-lncrna-ccdc26-restrains-the-growth-and-migration-of-glioma-cells-in-vitro-and-in-vivo-via-targeting-mir-203
#2
Shilei Wang, Yuzuo Hui, Xiaoming Li, Qingbin Jia
Gliomas are the most common primary brain tumors with high mortality. The treatment for gliomas is largely limited dueto the uncomprehending pathological mechanism. Here we aimed to investigate the effect of long non-coding RNA (lncRNA) coiled-coil domain-containing 26 (CCDC26) in gliomas progression. In our study, the expression of CCDC26 was found up-regulated in gliomas tissues and cell lines compared with normal tissues and cell lines. Further exploration detected decreased cell proliferation and increased cell apoptosis in U-251 and M059J cells transfected with CCDC26-siRNA...
June 9, 2017: Oncology Research
https://www.readbyqxmd.com/read/28596493/upregulation-of-long-noncoding-rna-hoxa-as3-promotes-tumor-progression-and-predicts-poor-prognosis-in-glioma
#3
Fan Wu, Chuanbao Zhang, Jinquan Cai, Fan Yang, Tingyu Liang, Xiaoyan Yan, Haoyuan Wang, Wen Wang, Jing Chen, Tao Jiang
Long noncoding RNAs (lncRNAs) have recently emerged as new potentially promising therapeutic targets in many cancers. However, their prognostic value and biological functions associated with glioma remain to be elucidated. Here, High-throughput RNAseq was performed to detect the expression profiles of lncRNAs in 325 human glioma tissues. It was shown that a novel lncRNA HOXA-AS3 was one of the most significantly upregulated lncRNAs in glioma tissues. Quantitative PCR further verified the increased expression of HOXA-AS3 in patient samples and glioma cell lines...
May 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28569381/lncrna-tp53tg1-participated-in-the-stress-response-under-glucose-deprivation-in-glioma
#4
Xin Chen, Yang Gao, Deheng Li, Bin Hao, Yiqun Cao
Gliomas are the most common brain tumors of the center nervous system. And long non-coding RNAs (lncRNAs) are non-protein coding transcripts, which have been considered as one type of gene expression regulator for cancer development. In this study, we investigated the role of lncRNA-TP53TG1 in response to glucose deprivation in human gliomas. The expression levels of TP53TG1 in glioma tissues and cells were analyzed by qRT-PCR. In addition, the influence of TP53TG1 on glucose metabolism related genes at the mRNA level during both high and low glucose treatment was detected by qRT-PCR...
June 1, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28551849/long-non-coding-rna-malat1-promotes-proliferation-and-suppresses-apoptosis-of-glioma-cells-through-derepressing-rap1b-by-sponging-mir-101
#5
Zhenjiang Li, Chenyang Xu, Bingqian Ding, Ming Gao, Xinting Wei, Nan Ji
Long non-coding RNAs (lncRNAs) have been recently shown to be dysregulated and closely related to several cancers. Here, we aimed to elucidate the function and the possible molecular mechanisms of lncRNA Metastasis-associated lung Adenocarcinoma transcript-1 (MALAT1) in human glioma. Quantitative real-time PCR (qRT-PCR) was used to detect the expressions of MALAT1, miR-101 and Rap1B mRNA in U251 and U87 cells. The protein level of Rap1B was examined by western blot assays. Moreover, the proliferation and apoptosis of U251 and U87 cells were determined by CCK-8 assay and flow cytometry analysis, respectively...
May 27, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28548636/long-non-coding-rna-uca1-targets-mir-122-to-promote-proliferation-migration-and-invasion-of-glioma-cells
#6
Yang Sun, Jun-Gong Jin, Wei-Yang Mi, Hao Wu, Shi-Rong Zhang, Qiang Meng, Shi-Tao Zhang
Glioma is the most common and lethal intracranial malignant tumor. Long non-coding RNAs (lncRNAs) have been identifiedas pivotal regulators in the tumorigenesis of glioma. However, the role of lncRNA urothelial carcinoma-associated 1 (UCA1) in the gliomagenesis is still unknown. The purpose of this study is to investigate the underlying function of UCA1 on glioma genesis. Results demonstrated that UCA1 was up-regulated in glioma tissue and indicated the poor prognosis. UCA1 knockdown induced by si-UCA1 significantly suppressed the proliferative, migrative and invasive activity of glioma cell lines (U87 and U251)...
May 5, 2017: Oncology Research
https://www.readbyqxmd.com/read/28501778/upregulation-of-the-long-non-coding-rna-snhg1-predicts-poor-prognosis-promotes-cell-proliferation-and-invasion-and-reduces-apoptosis-in-glioma
#7
Qiang Wang, Qing Li, Peng Zhou, Danni Deng, Lian Xue, Naiyuan Shao, Ya Peng, Feng Zhi
Long non-coding RNAs (lncRNAs), which are non-coding RNAs with a length above 200 nucleotides, have emerged as novel and important gene expression modulators in carcinogenesis. Recent evidence indicates that the lncRNA small nucleolar RNA host gene 1 (SNHG1) functions as an oncogene in several types of human cancers. However, its function in the development of glioma remains unknown. The aim of this research was to investigate the clinical aspects and biological mechanisms of SNHG1 in glioma. SNHG1 expression was measured in glioma tissues and cell lines by quantitative real-time PCR (qRT-PCR)...
July 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28493025/crnde-expression-positively-correlates-with-egfr-activation-and-modulates-glioma-cell-growth
#8
Karrie Mei-Yee Kiang, Xiao-Qin Zhang, Grace Pingde Zhang, Ning Li, Stephen Yin Cheng, Ming-Wai Poon, Jenny Kan-Suen Pu, Wai-Man Lui, Gilberto Ka-Kit Leung
BACKGROUND: The long non-coding RNA CRNDE has emerged as an important regulator in carcinogenesis and cancer progression. While CRNDE has previously been found to be the most highly upregulated lncRNA in glioma, detailed information on its roles in regulating cancer cell growth remains limited. OBJECTIVE: In the present study, we aimed at exploring the functional roles and underlying mechanisms of CRNDE in glioma. METHODS: We applied microarray data analysis to determine the prognostic significance of CRNDE in glioma patients and its correlation with epidermal growth factor receptor (EGFR) activation...
May 11, 2017: Targeted Oncology
https://www.readbyqxmd.com/read/28490034/long-noncoding-rna-crnde-promotes-proliferation-of-gastric-cancer-cells-by-targeting-mir-145
#9
Cheng En Hu, Pei Zhun Du, Hui Dong Zhang, Guang Jian Huang
BACKGROUND/AIMS: The colorectal neoplasia differentially expressed (CRNDE) gene is a long noncoding RNA (lncRNAs) that is upregulated in colorectal cancer and glioma. Here, we investigated the regulatory function of CRNDE in gastric cancer (GC). METHODS: CRNDE and miR-145 expression were assayed by qRT-PCR, and E2F3 protein expression was measured by western blotting. A luciferase reporter assay was used to detect the direct regulation of miR-145 by CRNDE. Cell viability and colony formation of human GC cells were detected using MTT and colony formation assay, respectively...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28489543/integrating-multiple-heterogeneous-networks-for-novel-lncrna-disease-association-inference
#10
Jingpu Zhang, Zuping Zhang, Zhigang Chen, Lei Deng
Accumulating experimental evidence has indicated that long non-coding RNAs (lncRNAs) are critical for the regulation of cellular biological processes implicated in many human diseases. However, only relatively few experimentally supported lncRNA-disease associations have been reported. Developing effective computational methods to infer lncRNA-disease associations is becoming increasingly important. Current network-based algorithms typically use a network representation to identify novel associations between lncRNAs and diseases...
May 4, 2017: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://www.readbyqxmd.com/read/28475287/lncrna-ccat1-promotes-glioma-tumorigenesis-by-sponging-mir-181b
#11
Bingzhou Cui, Baoshan Li, Qi Liu, Youqiang Cui
Colon cancer-associated transcript 1 (CCAT1), a long non-coding RNA (lncRNA), is upregulated and has a vital role in the pathogenesis of numerous cancers. Recently, its high expression was found in glioma tissues. miR-181b is downregulated in glioma and acts as a tumor suppressor. However, the exact mechanism of CCAT1 action in the regulation of glioma development remains unknown. CCAT1 and miR-181b expression was firstly examined in glioma tissue samples by real-time PCR. An RNA interference approach was used to downregulate CCAT1 expression and we analyzed the underlying mechanism of CCAT1 by using bioinformatics analysis, CCK-8 assay, Transwell assay, flow cytometry, luciferase assay, RNA immunoprecipitation, real-time PCR, Western blot, and xenograft models...
May 5, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28469789/long-non-coding-rna-xist-exerts-oncogenic-functions-in-human-glioma-by-targeting-mir-137
#12
Zong Wang, Jiangwei Yuan, Li Li, Yang Yang, Xuchang Xu, Ying Wang
Long non-coding RNA (lncRNA) X inactivate-specific transcript (XIST) acts as an important regulator in tumor progression. However, its expression and the underlying mechanism in glioma remain unclear. The aim of this study was to explore the potential function of XIST in glioma progression. In the present study, our data showed that the expression of XIST was significantly up-regulated in glioma tissues and enhanced the proliferation of glioma cells. The expression of miR-137 was significantly decreased in glioma tissues...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28425476/lncrnas2pathways-identifying-the-pathways-influenced-by-a-set-of-lncrnas-of-interest-based-on-a-global-network-propagation-method
#13
Junwei Han, Siyao Liu, Zeguo Sun, Yunpeng Zhang, Fan Zhang, Chunlong Zhang, Desi Shang, Haixiu Yang, Fei Su, Yanjun Xu, Chunquan Li, Huan Ren, Xia Li
Long non-coding RNAs (lncRNAs) have been demonstrated to play essential roles in diverse cellular processes and biological functions. Exploring the functions associated with lncRNAs may help provide insight into their underlying biological mechanisms. The current methods primarily focus on investigating the functions of individual lncRNAs; however, essential biological functions may be affected by the combinatorial effects of multiple lncRNAs. Here, we have developed a novel computational method, LncRNAs2Pathways, to identify the functional pathways influenced by the combinatorial effects of a set of lncRNAs of interest based on a global network propagation algorithm...
April 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28423669/the-novel-long-non-coding-rna-talnec2-regulates-tumor-cell-growth-and-the-stemness-and-radiation-response-of-glioma-stem-cells
#14
Shlomit Brodie, Hae Kyung Lee, Wei Jiang, Simona Cazacu, Cunli Xiang, Laila M Poisson, Indrani Datta, Steve Kalkanis, Doron Ginsberg, Chaya Brodie
Despite advances in novel therapeutic approaches for the treatment of glioblastoma (GBM), the median survival of 12-14 months has not changed significantly. Therefore, there is an imperative need to identify molecular mechanisms that play a role in patient survival. Here, we analyzed the expression and functions of a novel lncRNA, TALNEC2 that was identified using RNA seq of E2F1-regulated lncRNAs. TALNEC2 was localized to the cytosol and its expression was E2F1-regulated and cell-cycle dependent. TALNEC2 was highly expressed in GBM with poor prognosis, in GBM specimens derived from short-term survivors and in glioma cells and glioma stem cells (GSCs)...
May 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28381990/knockdown-of-long-non-coding-rna-kcnq1ot1-restrained-glioma-cells-malignancy-by-activating-mir-370-ccne2-axis
#15
Wei Gong, Jian Zheng, Xiaobai Liu, Yunhui Liu, Junqing Guo, Yana Gao, Wei Tao, Jiajia Chen, Zhiqing Li, Jun Ma, Yixue Xue
Accumulating evidence has highlighted the potential role of long non-coding RNAs (lncRNAs) as biomarkers and therapeutic targets in solid tumors. Here, we elucidated the function and possible molecular mechanisms of lncRNA KCNQ1OT1 in human glioma U87 and U251 cells. Quantitative Real-Time polymerase chain reaction (qRT-PCR) demonstrated that KCNQ1OT1 expression was up-regulated in glioma tissues and cells. Knockdown of KCNQ1OT1 exerted tumor-suppressive function in glioma cells. Moreover, a binding region was confirmed between KCNQ1OT1 and miR-370 by dual-luciferase assays...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28379612/the-long-non-coding-rna-tp73-as1-interacted-with-mir-142-to-modulate-brain-glioma-growth-through-hmgb1-rage-pathway
#16
Rong Zhang, Hekun Jin, Fan Lou
P73 antisense RNA 1T (non-protein coding), also known as TP73-AS1 or PDAM, is a long non-coding RNA which may regulate apoptosis via regulation of p53-dependent anti-apoptotic genes. An abnormal change of TP73-AS1 expression was noticed in cancers. The effects of TP73-AS1 in brain glioma growth and the underlying mechanism remain unclear so far. In the present study, TP73-AS1 was specifically upregulated in brain glioma tissues and cell lines and was associated with poorer prognosis in patients with glioma...
April 5, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28368417/oncogenic-effects-of-evolutionarily-conserved-noncoding-rna-econexin-on-gliomagenesis
#17
S Deguchi, K Katsushima, A Hatanaka, K Shinjo, F Ohka, T Wakabayashi, H Zong, A Natsume, Y Kondo
Accumulating studies have demonstrated the importance of long noncoding RNAs (lncRNAs) during oncogenic transformation. However, because most lncRNAs are currently uncharacterized, the identification of novel oncogenic lncRNAs is difficult. Given that intergenic lncRNA have substantially less sequence conservation patterns than protein-coding genes across species, evolutionary conserved intergenic lncRNAs are likely to be functional. The current study identified a novel intergenic lncRNA, LINC00461 (ECONEXIN) using a combined approach consisting of searching lncRNAs by evolutionary conservation and validating their expression in a glioma mouse model...
April 3, 2017: Oncogene
https://www.readbyqxmd.com/read/28350082/hotair-upregulates-an-18-gene-cell-cycle-related-mrna-network-in-glioma
#18
Kai Huang, Jia Sun, Chao Yang, Yunfei Wang, Bingcong Zhou, Chunsheng Kang, Lei Han, Qixue Wang
HOTAIR is a tumor promoting long non-coding RNA (lncRNA) with roles in multiple cancers. However, the role of HOTAIR in glioma has not been well charaterized. Genes that positively correlated with HOTAIR were identified from the Chinese Glioma Genome Atlas and constructed into an interacting network. In total, 18 genes with P-values <0.01 were further extracted and constructed into a subnetwork. Real-time PCR, western blot and immunofluorescence analyses were employed to examine the expression of the genes after HOTAIR overexpression or knockdown...
March 7, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28338200/glioma-cells-promote-angiogenesis-through-the-release-of-exosomes-containing-long-non-coding-rna-pou3f3
#19
H-L Lang, G-W Hu, Y Chen, Y Liu, W Tu, Y-M Lu, L Wu, G-H Xu
OBJECTIVE: Angiogenesis is a key event in the progression of gliomas, and emerging evidence suggests that exosomes are signaling extracellular organelles that modulate the tumor microenvironment and promote angiogenesis and tumor progression. This study aimed to explore the mechanism by which glioma-derived exosomes affect angiogenesis. MATERIALS AND METHODS: qRT-PCR was used to determine the expression level of linc-POU3F3 in glioma tissue as well as glioma cell lines...
March 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28293170/an-insight-into-the-increasing-role-of-lncrnas-in-the-pathogenesis-of-gliomas
#20
REVIEW
Yuanliang Yan, Zhijie Xu, Zhi Li, Lunquan Sun, Zhicheng Gong
Long non-coding RNAs (LncRNAs) are essential epigenetic regulators with critical roles in tumor initiation and malignant progression. However, the roles and mechanisms of aberrantly expressed lncRNAs in the pathogenesis of gliomas are not fully understood. With the development of deep sequencing analyses, an extensive amount of functional non-coding RNAs has been discovered in glioma tissues and cell lines. Additionally, the contributions of several lncRNAs, such as Hox transcript antisense intergenic RNA, H19 and Colorectal neoplasia differentially expressed, previously reported to be involved in other pathogenesis and processes to the oncogenesis of glioblastoma are currently addressed...
2017: Frontiers in Molecular Neuroscience
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