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https://www.readbyqxmd.com/read/29151415/-diagnostic-value-of-citrulline-and-intestinal-fatty-acid-binding-protein-on-acute-gastrointestinal-injury-in-critical-patients-a-prospective-study-of-530-patients
#1
Jing Wang, Limei Yu, Yonghong Xia, Yanling Gao, Wenbo Yu, Haihong Sun, Yizhu Sun
OBJECTIVE: To observe the incidence of acute gastrointestinal injury (AGI) in intensive care unit (ICU) patients, and to approach the value of serum citrulline and intestinal fatty acid binding protein (IFABP) on diagnosis of AGI in critical patients. METHODS: A prospective study was conducted. 576 critical patients admitted to ICU of Yantai Yuhuangding Hospital from February 2016 to February 2017 were enrolled. According to the AGI classification proposed by European Society of Intensive Care Medicine (ESICM) in 2012, the AGI and severity of the patients were observed...
November 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29146379/lt-adjuvant-modulates-epitope-specificity-and-improves-the-efficacy-of-murine-antibodies-elicited-by-sublingual-vaccination-with-the-n-terminal-domain-of-streptococcus-mutans-p1
#2
Milene Tavares Batista, Ewerton Lucena Ferreira, Gisela de Souza Pereira, Phillip Stafford, Denicar Lina Nascimento Fabris Maeda, Juliana Falcão Rodrigues, L Jeannine Brady, Stephen Albert Johnston, Luís Carlos de Souza Ferreira, Rita de Cássia Café Ferreira
In this study, we evaluated the immunogenicity, protective efficacy and peptide-based immune signatures of antibodies raised in mice after sublingual immunization with a recombinant form of the P1 (aka AgI/II, PAc) adhesin (P139-512) of Streptococcus mutans, a major etiological agent of dental caries. Sublingual administration of P139-512 in combination with the mucosal adjuvant LTK4R (a derivative of heat-labile LT toxin) induced strong and long-lasting systemic and mucosal immune responses. Incorporation of the adjuvant resulted in an enhancement of the anti-adhesive and anti-colonization activity against S...
November 13, 2017: Vaccine
https://www.readbyqxmd.com/read/29141376/-clinical-significance-of-acute-gastrointestinal-injury-grades-in-inflammatory-response-of-critically-ill-patients
#3
J Wang, Y L Gao, W W Yu, Y H Xia, Y Z Sun
Objective: To explore the value of acute gastrointestinal injury (AGI) grades in inflammatory response of critically ill patients. Methods: Ptients with AGI severity from Ⅰ to Ⅳ were randomly selected(20 for each)from July 2014 to June 2015 in ICU of Yantai Yuhuangding Hospital. The expression of NF-κB were detected by immunofluorescence. The expression of TNF-α and IL-6 were detected by enzyme linked immunosorbent assay (ELISA). Procalcitonin (PCT) and C reactive protein (CRP) were measured. Statistical analysis was carried out...
November 14, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29124880/costus-spiralis-jacq-roscoe-a-novel-source-of-flavones-with-%C3%AE-glycosidase-inhibitory-activity
#4
Ana P de Oliveira, Juliana S Coppede, Bianca W Bertoni, Antônio E M Crotti, Suzelei C França, Ana Maria S Pereira, Silvia H Taleb-Contini
Costus spiralis, a plant used in traditional Brazilian medicine for the treatment of complications in diabetes, was investigated. Assay of hexane, ethyl acetate, methanol and aqueous fractions obtained by partition of a crude methanol extract of dried leaves of C. spiralis revealed that AGI activity was confined to the ethyl acetate fraction. Purification of this fraction yielded schaftoside and isoschaftoside. The AGI activities of the two flavones were lower than, but comparable with, that of the anti-diabetic drug acarbose...
November 10, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/29113364/alpha-glucosidase-inhibitors-and-risk-of-cancer-in-patients-with-diabetes-mellitus-a-systematic-review-and-meta-analysis
#5
Yiming Zhao, Yongjian Wang, Hanyu Lou, Lizhen Shan
Several studies have shown that anti-diabetic medications may modify the risk of cancer. We performed a systematic review and meta-analysis to evaluate the effect of alpha-glucosidase inhibitors (AGIs) on the risk of cancer in patients with diabetes mellitus. We conducted a systematic search of Medline, EMBASE, and Web of Science databases, up to September 30, 2016. Random-effects model was used to estimate the summary odds ratios (ORs) with 95% CI. Twenty-five studies (14 cohort, 7 case-control, and 4 randomized controlled trials) involving 1,285,433 patients with diabetes were included...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29112160/reclamation-of-marine-chitinous-materials-for-the-production-of-%C3%AE-glucosidase-inhibitors-via-microbial-conversion
#6
Van Bon Nguyen, San-Lang Wang
Six kinds of chitinous materials have been used as sole carbon/nitrogen (C/N) sources for producing α-glucosidase inhibitors (aGI) by Paenibacillus sp. TKU042. The aGI productivity was found to be highest in the culture supernatants using demineralized crab shell powder (deCSP) and demineralized shrimp shell powder (deSSP) as the C/N source. The half maximal inhibitory concentration (IC50) and maximum aGI activity of fermented deCSP (38 µg/mL, 98%), deSSP (108 µg/mL, 89%), squid pen powder (SPP) (422 µg/mL, 98%), and shrimp head powder (SHP) (455 µg/mL, 92%) were compared with those of fermented nutrient broth (FNB) (81 µg/mL, 93%) and acarbose (1095 µg/mL, 74%), a commercial antidiabetic drug...
November 7, 2017: Marine Drugs
https://www.readbyqxmd.com/read/29100990/evaluation-of-the-multiplex-pcr-allplex-gi-assay-in-the-detection-of-bacterial-pathogens-in-diarrheic-stool-samples
#7
Ariadna Martín, Ana Pérez-Ayala, Fernando Chaves, David Lora, M Ángeles Orellana
Rapid and accurate detection of the pathogens that cause gastrointestinal infection is important for appropriate therapy and proper infection control. This study assesses the performance of a new molecular assay for simultaneous detection of 13 different gastrointestinal bacteria in stool specimens. Using the Allplex GI-Bacteria (AGI-BI/AGI-BII) assay, a total of 394 stool samples were tested and the results were compared with culturing on selective differential followed by identification by mass spectroscopy...
October 31, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/29100898/effectiveness-of-national-and-subnational-infection-prevention-and-control-interventions-in-high-income-and-upper-middle-income-countries-a-systematic-review
#8
REVIEW
Lesley Price, Jennifer MacDonald, Lynn Melone, Tracey Howe, Paul Flowers, Kay Currie, Evonne Curran, Valerie Ness, Debbie Waddell, Sarkis Manoukian, Agi McFarland, Claire Kilpatrick, Julie Storr, Anthony Twyman, Benedetta Allegranzi, Jacqui Reilly
Evidence-based guidance for national infection prevention and control (IPC) programmes is needed to support national and global capacity building to reduce health-care-associated infection and antimicrobial resistance. In this systematic review we investigate evidence on the effectiveness of IPC interventions implemented at national or subnational levels to inform the development of WHO guidelines on the core components of national IPC programmes. We searched CENTRAL, CINAHL, Embase, MEDLINE, and WHO IRIS databases for publications between Jan 1, 2000, and April 19, 2017...
October 31, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29100106/l-mimosine-and-hypoxia-enhance-angiopoietin-like-4-production-involving-hypoxia-inducible-factor-1alpha-insights-from-monolayer-and-spheroid-cultures-of-dental-pulp-derived-cells-and-tooth-slice-cultures
#9
Klara Janjić, Umar Alhujazy, Andreas Moritz, Hermann Agis
OBJECTIVE: Angiopoietin-like 4 (Angptl4) is an angiogenesis modulating signaling factor and as such involved in blood vessel formation but also in hard tissue resorption. Here we hypothesized that the hypoxia mimetic agent L-mimosine (L-MIM) and hypoxia stimulate the production of Angptl4 in the dental pulp. MATERIAL AND METHODS: Monolayer and spheroid cultures of primary human dental pulp-derived cells (DPC) were treated with L-MIM or hypoxia. Furthermore, tooth slice cultures were performed...
October 16, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29096873/sexual-satisfaction-following-bariatric-surgery-a-prospective-exploratory-study
#10
Manuel Ferrer-Márquez, María Ángeles Pomares-Callejón, Inmaculada Fernández-Agis, Ricardo Belda-Lozano, Elisabet Vidaña-Márquez, Alberto Soriano-Maldonado
INTRODUCTION: Bariatric surgery improves sexual function in obese individuals, although the extent to which sexual satisfaction is improved following surgery is unknown. The aims of this study were 1) to describe sexual satisfaction in severely/morbidly obese men and women candidates for bariatric surgery; 2) to assess the effects of bariatric surgery on sexual satisfaction at 12-months follow-up; and 3) to assess whether weight changes at follow-up following bariatric surgery are associated with changes in sexual satisfaction...
October 30, 2017: Cirugía Española
https://www.readbyqxmd.com/read/29073468/enhanced-escherichia-coli-inactivation-and-oxytetracycline-hydrochloride-degradation-by-a-z-scheme-silver-iodide-decorated-bismuth-vanadate-nanocomposite-under-visible-light-irradiation
#11
Dan-Lin Guan, Cheng-Gang Niu, Xiao-Ju Wen, Hai Guo, Can-Hui Deng, Guang-Ming Zeng
Novel Z-scheme AgI/BiVO4 photocatalysts were fabricated by a chemical deposition-precipitation approach. The photocatalytic activities of the obtained catalysts were evaluated by disinfection of Escherichia coli (E. coli) and degradation of oxytetracycline hydrochloride (OTC-HCl) under visible-light irradiation. The BA3 (contained 9.09% of AgI) exhibited the highest photocatalytic activity and maintained good stability. It could completely inactivate 7.0×10(7) CFU/mL of E. coli in 50 min and degrade 80% of OTC-HCl in 60 min...
October 17, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29068991/the-prescribing-trend-of-oral-antidiabetic-agents-for-type-2-diabetes-in-taiwan-an-8-year-population-based-study
#12
Wei-Min Chu, Hsin-En Ho, Kuang-Hua Huang, Yu-Tse Tsan, Yi-Sheng Liou, Yueh-Hsin Wang, Meng-Chih Lee, Yu-Ching Li
The purpose of this study was to evaluate the prescription trend and pattern of oral antidiabetic (OAD) medications, which are extensively used worldwide for treating type 2 diabetes, in 2 age groups.In this population-based study, data obtained from the National Health Insurance Research Database, Taiwan, were analyzed to investigate the prescription trend of all types of OAD medications during 2005 to 2012. We used descriptive statistics to demonstrate the trend of prescription patterns stratified by age (aged 65 years and above or younger than 65)...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29047219/addition-of-dipeptidyl-peptidase-4-inhibitors-to-insulin-treatment-in-type-2-diabetes-patients-a-meta-analysis
#13
Wenjia Yang, Xiaoling Cai, Xueying Gao, Yifei Chen, Chen Ling, Linong Ji
AIMS: To evaluate the efficacy and safety of combining insulin therapy with dipeptidyl peptidase 4 (DPP-4) inhibitors compared to combining insulin therapy with placebo or other antihyperglycaemic agents. MATERIALS AND METHODS: A literature search was conducted via electronic databases. The inclusion criteria were randomized controlled trials (RCTs) comparing the addition of DPP-4 inhibitors to insulin with the addition of placebo or other active hypoglycaemic agents to insulin therapy, study duration of no less than 12 weeks performed in type 2 diabetes patients, and the availability of outcome data to evaluate a change in the HbA1c ...
October 19, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29042557/mechanocaloric-effects-in-superionic-thin-films-from-atomistic-simulations
#14
Arun K Sagotra, Daniel Errandonea, Claudio Cazorla
Solid-state cooling is an energy-efficient and scalable refrigeration technology that exploits the adiabatic variation of a crystalline order parameter under an external field (electric, magnetic, or mechanic). The mechanocaloric effect bears one of the greatest cooling potentials in terms of energy efficiency owing to its large available latent heat. Here we show that giant mechanocaloric effects occur in thin films of well-known families of fast-ion conductors, namely Li-rich (Li3OCl) and type-I (AgI), an abundant class of materials that routinely are employed in electrochemistry cells...
October 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/29036849/newly-developed-learning-and-verbal-memory-test-tamv-i-normative-data-for-spanish-speaking-pediatric-population
#15
D Rivera, L Olabarrieta-Landa, B V Rabago Barajas, M J Irías Escher, M Saracostti Schwartzman, R Ferrer-Cascales, P Martín-Lobo, J A Calderón, M A Aguilar Uriarte, A I Peñalver Guia, R Camlla Ynga, C E García-Guerrero, I Fernandez-Agis, A García-Gómez-Pastrana, J A Ibañéz-Alfonso, H Gómez, J Galarza-Del-Angel, C García de la Cadena, J C Arango-Lasprilla
OBJECTIVE: To generate normative data for the Learning and Verbal Memory Test (TAMV-I) in Spanish-speaking pediatric populations. METHOD: The sample consisted of 4,373 healthy children from nine countries in Latin America (Chile, Cuba, Ecuador, Guatemala, Honduras, Mexico, Paraguay, Peru, and Puerto Rico) and Spain. Each participant was administered the TAMV-I as part of a larger neuropsychological battery. Free recall, memory delay and recognition scores were normed using multiple linear regressions and standard deviations of residual values...
October 10, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/29035656/clinical-laboratory-and-hemostatic-findings-in-cats-with-naturally-occurring-sepsis
#16
Sigal Klainbart, Limor Agi, Tali Bdolah-Abram, Efrat Kelmer, Itamar Aroch
OBJECTIVE To characterize clinical and laboratory findings in cats with naturally occurring sepsis, emphasizing hemostasis-related findings, and evaluate these variables for associations with patient outcomes. DESIGN Prospective, observational, clinical study. ANIMALS 31 cats with sepsis and 33 healthy control cats. PROCEDURES Data collected included history; clinical signs; results of hematologic, serum biochemical, and hemostatic tests; diagnosis; and outcome (survival vs death during hospitalization or ≤ 30 days after hospital discharge)...
November 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29035028/stress-mediated-enhancement-of-ionic-conductivity-in-fast-ion-conductors
#17
Arun K Sagotra, Claudio Cazorla
Finding solid-state electrolytes with high ionic conductivity near room temperature is an important prerequisite for developing all-solid-state electrochemical batteries. Here, we investigate the effects of point defects (vacancies) and biaxial stress on the superionic properties of fast-ion conductors (represented by the archetypal compounds CaF2, Li-rich antiperovskite Li3OCl, and AgI) by using classical molecular dynamics and first-principles simulation methods. We find that the critical superionic temperature of all analyzed families of fast-ion conductors can be reduced by several hundreds of degrees through the application of relatively small biaxial stresses (|σ| ≤ 1 GPa) on slightly defective samples (cv ∼ 1%)...
November 8, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29031292/a-new-integrated-tlc-mu-atr-sers-advanced-approach-for-the-identification-of-trace-amounts-of-dyes-in-mixtures
#18
Giorgia Sciutto, Silvia Prati, Irene Bonacini, Lucio Litti, Moreno Meneghetti, Rocco Mazzeo
The present research is focused on the setting up of an advanced analytical system for the detection of synthetic dyes. The system is based on the combination of an innovative thin layer chromatography (TLC) plate coupled with enhanced infrared (MU-ATR, metal underlayer attenuated total reflection) and Surface Enhanced Raman (SERS) spectroscopy. In particular, a TLC plate made of silver iodide (AgI) applied onto a gold coated glass slide (AgI@Au) is proposed as an efficient stationary phase for the separation of dyes mixtures...
October 23, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28979070/%C3%AE-glucosidase-inhibitory-activity-of-selected-malaysian-plants
#19
REVIEW
Dzatil Awanis Mohd Bukhari, Mohammad Jamshed Siddiqui, Siti Hadijah Shamsudin, Md Mukhlesur Rahman, Siti Zaiton Mat So'ad
Diabetes is a common metabolic disease indicated by unusually high plasma glucose level that can lead to major complications such as diabetic neuropathy, retinopathy, and cardiovascular diseases. One of the effective therapeutic managements of the disease is to reduce postprandial hyperglycemia through inhibition of α-glucosidase, a carbohydrate-hydrolyzing enzyme to retard overall glucose absorption. In recent years, a plenty of research works have been conducted looking for novel and effective α-glucosidase inhibitors (AGIs) from natural sources as alternatives for the synthetic AGI due to their unpleasant side effects...
July 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/28976509/dissociative-iodomethane-adsorption-on-ag-mor-and-the-formation-of-agi-clusters-an-ab-initio-molecular-dynamics-study
#20
Tomáš Bučko, Siwar Chibani, Jean-François Paul, Laurent Cantrel, Michael Badawi
Radioactive iodine species belong to the most dangerous components of nuclear effluents and waste produced by nuclear facilities. In this work, we use computer simulations at the periodic DFT level to investigate dissociative adsorption of iodomethane on silver-exchanged mordenite, which is among the most effective sorbents of iodine species available today. The structure, energetics, and mobility of complexes Ag-(CH3I) and Ag-(CH3I)2 formed upon adsorption of iodomethane on Ag(+) sites are investigated using the ab initio MD approach...
October 18, 2017: Physical Chemistry Chemical Physics: PCCP
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