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https://www.readbyqxmd.com/read/28725274/news-in-al-amyloidosis-ash-2016-a%C3%A2-rapidly-evolving-field-of-investigation
#1
REVIEW
Hermine Agis
Amyloidosis is a rare but life-threatening protein misfolding disease. The early diagnosis and enrollment of patients into multicentre trials is of great importance, as is the need for intensive collaboration between multiple medical departments and experienced specialists. In the following review, the most interesting abstracts from the annual American Society of Hematology (ASH) meeting in 2016 are presented. The topics include the limitations of established biomarkers in risk assessment and response evaluation, the introduction of a new biomarker, the comparison of different treatment sequences and the efficacy of a multiple drug regimen in light-chain (AL) amyloidosis...
2017: Memo
https://www.readbyqxmd.com/read/28723559/kmt2a-and-kmt2b-mediate-memory-function-by-affecting-distinct-genomic-regions
#2
Cemil Kerimoglu, M Sadman Sakib, Gaurav Jain, Eva Benito, Susanne Burkhardt, Vincenzo Capece, Lalit Kaurani, Rashi Halder, Roberto Carlos Agís-Balboa, Roman Stilling, Hendrik Urbanke, Andrea Kranz, A Francis Stewart, Andre Fischer
Kmt2a and Kmt2b are H3K4 methyltransferases of the Set1/Trithorax class. We have recently shown the importance of Kmt2b for learning and memory. Here, we report that Kmt2a is also important in memory formation. We compare the decrease in H3K4 methylation and de-regulation of gene expression in hippocampal neurons of mice with knockdown of either Kmt2a or Kmt2b. Kmt2a and Kmt2b control largely distinct genomic regions and different molecular pathways linked to neuronal plasticity. Finally, we show that the decrease in H3K4 methylation resulting from Kmt2a knockdown partially recapitulates the pattern previously reported in CK-p25 mice, a model for neurodegeneration and memory impairment...
July 18, 2017: Cell Reports
https://www.readbyqxmd.com/read/28709443/severity-of-acute-gastrointestinal-injury-grade-is-a-predictor-of-all-cause-mortality-in-critically-ill-patients-a-multicenter-prospective-observational-study
#3
Bangchuan Hu, Renhua Sun, Aiping Wu, Yin Ni, Jingquan Liu, Feng Guo, Lijun Ying, Guoping Ge, Aijun Ding, Yunchao Shi, Changwen Liu, Lei Xu, Ronglin Jiang, Jun Lu, Ronghai Lin, Yannan Zhu, Weidong Wu, Bo Xie
BACKGROUND: In 2012, the European Society of Intensive Care Medicine proposed a definition for acute gastrointestinal injury (AGI) based on current medical evidence and expert opinion. The aim of the present study was to evaluate the feasibility of using the current AGI grading system and to investigate the association between AGI severity grades with clinical outcome in critically ill patients. METHODS: Adult patients at 14 general intensive care units (ICUs) with an expected ICU stay ≥24 h were prospectively studied...
July 14, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28709107/efficient-bacterial-inactivation-with-z-scheme-agi-bi2moo6-under-visible-light-irradiation
#4
Jialiang Liang, Fuyang Liu, Jun Deng, Mian Li, Meiping Tong
A novel Z-scheme AgI/Bi2MoO6 hybrid photocatalyst was fabricated via a solvothermal-precipitation approach to disinfect bacteria in water. Powder X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), scanning electron microscopic (SEM) equipped with energy-dispersive X-ray spectroscopy (EDX), high resolution transmission electron microscope (HRTEM), UV-vis diffuse reflectance spectra (DRS), as well as photoluminescence spectra (PL) were employed to characterize the fabricated photocatalyst. Due to the stronger redox potential and better separation of charge carriers induced by the Z-scheme structure, the optimal synthesized AgI/Bi2MoO6 exhibited excellent disinfection activity towards both Gram-negative strain Escherichia coli (E...
July 6, 2017: Water Research
https://www.readbyqxmd.com/read/28705175/serotype-specific-role-of-antigen-i-ii-in-the-initial-steps-of-the-pathogenesis-of-the-infection-caused-by-streptococcus-suis
#5
Sarah Chuzeville, Jean-Philippe Auger, Audrey Dumesnil, David Roy, Sonia Lacouture, Nahuel Fittipaldi, Daniel Grenier, Marcelo Gottschalk
Streptococcus suis is one of the most important post-weaning porcine bacterial pathogens worldwide. The serotypes 2 and 9 are often considered the most virulent and prevalent serotypes involved in swine infections, especially in Europe. However, knowledge of the bacterial factors involved in the first steps of the pathogenesis of the infection remains scarce. In several pathogenic streptococci, expression of multimodal adhesion proteins known as antigen I/II (AgI/II) have been linked with persistence in the upper respiratory tract and the oral cavity, as well as with bacterial dissemination...
July 14, 2017: Veterinary Research
https://www.readbyqxmd.com/read/28702908/water-quality-and-health-in-northern-canada-stored-drinking-water-and-acute-gastrointestinal-illness-in-labrador-inuit
#6
Carlee J Wright, Jan M Sargeant, Victoria L Edge, James D Ford, Khosrow Farahbakhsh, Inez Shiwak, Charlie Flowers, Sherilee L Harper
One of the highest self-reported incidence rates of acute gastrointestinal illness (AGI) in the global peer-reviewed literature occurs in Inuit communities in the Canadian Arctic. This high incidence of illness could be due, in part, to the consumption of contaminated water, as many northern communities face challenges related to the quality of municipal drinking water. Furthermore, many Inuit store drinking water in containers in the home, which could increase the risk of contamination between source and point-of-use (i...
July 12, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28696664/evaluation-of-silver-zeolites-sorbents-toward-their-ability-to-promote-stable-ch3i-storage-as-agi-precipitates
#7
Bruno Azambre, Mouheb Chebbi
In this study, up to 13 different silver zeolites sorbents were prepared by repeated ion exchange from their parent structures (FAU X and Y, MOR, *BEA, MFI, FER), characterized, and evaluated for their ability to capture methyl iodide in the context of a nuclear severe accident. A novel methodology was implemented to establish structure-activity relationships between sorbent properties and iodine trapping stability. After saturation of the zeolite bed with CH3I during a dynamic breakthrough experiment at 100 °C, a two-step quantitative desorption method was elaborated with the aim to quantify separately the CH3I fractions trapped by physisorption, chemisorption, or reacted as AgI precipitates...
July 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28685995/meta-analysis-and-critical-review-on-the-efficacy-and-safety-of-alpha-glucosidase-inhibitors-in-asian-and-non-asian-populations
#8
Xueying Gao, Xiaoling Cai, Wenjia Yang, Yifei Chen, Xueyao Han, Linong Ji
AIMS: To evaluate the efficacy and safety of alpha glucosidase inhibitors (AGI) in Asian and non-Asian type 2 diabetic patients. MATERIALS AND METHODS: Studies were identified through a literature search of MEDLINE, EMBASE, and other databases until December 2016. All statistical analyses were conducted in Review Manager statistical software by computing the weighted mean difference (WMD) or odds ratio (OR) and 95% confidence interval (CI). RESULTS: A total of 67 studies were included...
July 7, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28670349/epigenetic-mechanisms-during-ageing-and-neurogenesis-as-novel-therapeutic-avenues-in-human-brain-disorders
#9
REVIEW
Raúl Delgado-Morales, Roberto Carlos Agís-Balboa, Manel Esteller, María Berdasco
Ageing is the main risk factor for human neurological disorders. Among the diverse molecular pathways that govern ageing, epigenetics can guide age-associated decline in part by regulating gene expression and also through the modulation of genomic instability and high-order chromatin architecture. Epigenetic mechanisms are involved in the regulation of neural differentiation as well as in functional processes related to memory consolidation, learning or cognition during healthy lifespan. On the other side of the coin, many neurodegenerative diseases are associated with epigenetic dysregulation...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28662917/accumulative-scfv-fc-antibody-gene-integration-into-the-hprt-chromosomal-locus-of-chinese-hamster-ovary-cells
#10
Xue Wang, Yoshinori Kawabe, Risa Kato, Takeshi Hada, Akira Ito, Yoshimasa Yamana, Masako Kondo, Masamichi Kamihira
We have previously developed an accumulative site-specific gene integration system (AGIS) using Cre-recombinase and mutated loxP sites. AGIS enables repeated transgene integration into a predetermined chromosomal site in mammalian cells. However, the process of establishing cells with multiple integrated copies of the transgene is still time-consuming. In the present study, we describe an improved version of AGIS that facilitates and accelerates the establishment of high-producer Chinese hamster ovary (CHO) cells...
June 26, 2017: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/28656722/formation-of-spheroids-by-dental-pulp-derived-cells-in-the-presence-of-hypoxia-and-hypoxia-mimetic-agents
#11
K Janjić, B Lilaj, A Moritz, H Agis
AIM: To evaluate the impact of hypoxia and hypoxia mimetic agents (HMA) on the formation and activity of spheroids by dental pulp-derived cells (DPC). METHODOLOGY: DPC on agarose-coated plates were treated with hypoxia and the HMA dimethyloxallyl glycine (DMOG), desferrioxamine (DFO) and L-mimosine (L-MIM). Images of spheroids were taken directly after seeding and at 6h and 24h. Spheroid sizes were quantified by area measurement with ImageJ software. Viability was assessed with Live-Dead staining, MTT and resazurin-based toxicity assay...
June 28, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/28655919/facile-fabrication-of-nanofibrillated-chitin-ag2o-heterostructured-aerogels-with-high-iodine-capture-efficiency
#12
Runan Gao, Yun Lu, Shaoliang Xiao, Jian Li
Nanofibrillated chitin/Ag2O aerogels were fabricated for radioiodine removal. Chitin was first fabricated into nanofibers with abundant acetyl amino groups (-NHCOCH3) on the surface. Then, highly porous chitin nanofiber (ChNF) aerogels were obtained via freeze-drying. The ChNF aerogels exhibited a low bulk density of 2.19 mg/cm(3) and a high specific surface area of 179.71 m(2)/g. Ag2O nanoparticles were evenly anchored on the surfaces of ChNF scaffolds via strong interactions with -NHCOCH3 groups, subsequently yielding Ag2O@ChNF heterostructured aerogels...
June 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28654267/ternary-silver-halide-nanocrystals
#13
Sasitha C Abeyweera, Kowsalya D Rasamani, Yugang Sun
Nanocrystalline silver halides (AgX) such as AgCl, AgBr, and AgI, a class of semiconductor materials with characteristics of both direct and indirect band gaps, represent the most crucial components in traditional photographic processing. The nanocrystal surfaces provide sensitivity specks that can turn into metallic silver, forming an invisible latent image, upon exposure to light. The photographic processing implies that the AgX nanoparticles possess unique properties. First, pristine AgX nanoparticles absorb light only at low efficiency to convert surface AgX into tiny clusters of silver atoms...
June 27, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28635152/a-novel-dna-structure-containing-agi-mediated-g-g-and-c-c-base-pairs
#14
Hehua Liu, Fusheng Shen, Phensinee Haruehanroengra, Qingqing Yao, Yunshan Cheng, Yiqing Chen, Chun Yang, Jing Zhang, Baixing Wu, Qiang Luo, Ruixue Cui, Jixi Li, Jinbiao Ma, Jia Sheng, Jianhua Gan
Metallo-base pairs have been extensively utilized in many research fields, including genetic code extension, novel therapeutics development, and various nanodevice designs. Compared to other cations, AgI is more flexible in pairing with natural base pairs. Herein, we present a DNA structure containing two C-AgI-C pairs and one first time reported G-AgI-G pair in a short 8mer DNA strand. This structure not only discloses the detailed insights into these AgI-base pairing patterns in DNA, but also represents the first nonhelical DNA structure driven by the heavy metal ions, further contributing to the structural diversity of DNA...
June 20, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28631531/interleukin-1-receptor-antagonist-anakinra-intravenous-immunoglobulin-and-corticosteroids-in-the-management-of-critically-ill-adult-patients-with-hemophagocytic-lymphohistiocytosis
#15
Philipp Wohlfarth, Hermine Agis, Guido A Gualdoni, Johannes Weber, Thomas Staudinger, Peter Schellongowski, Oliver Robak
BACKGROUND: Hemophagocytic lymphohistiocytosis (HLH) causes multiple organ dysfunction frequently leading to intensive care unit (ICU) referral and/or death. We report on a series of critically ill adult patients treated with a non-etoposide-based regimen including interleukin 1 antagonist anakinra, intravenous immunoglobulin (IVIG), and/or corticosteroids (CS) for HLH. METHODS: Eight adult (≥18 years) ICU patients having received treatment with anakinra ± IVIG ± CS for HLH between March 2014 and March 2016 at a large tertiary care university hospital (Medical University of Vienna, Vienna, Austria) were retrospectively analyzed...
January 1, 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/28625262/-predictive-value-of-sofa-score-combined-agi-grading-system-in-elderly-patients-with-sepsis-a-retrospective-analysis-with-91-patients
#16
Lingling Wang, Rui Chen, Zexun Mo, Jiahui Dong, Zhaokun Sun, Fei Xiao, Shaoting Hu, Richeng Xiong, Jie Sun, Zhou Yu, Zhenhui Guo
OBJECTIVE: To explore the predictive value of sequential organ failure assessment (SOFA) score combined the acute gastrointestinal injury (AGI) grading system in critical elderly patients with sepsis. METHODS: A retrospective analysis was conducted. Elderly patients with sepsis aged > 60 years admitted to medical intensive care unit (MICU) of General Hospital of Guangzhou Military Command from March 2014 to December 2015 and experiencing critical care over 48 hours were enrolled...
February 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28624733/gastrointestinal-illness-linked-to-incidents-in-drinking-water-distribution-networks-in-sweden
#17
Melle Säve-Söderbergh, John Bylund, Annika Malm, Magnus Simonsson, Jonas Toljander
During recent years, knowledge gaps on drinking water-related gastrointestinal illness have been identified, especially for non-epidemic cases. Pathogen contamination of drinking water during distribution has been suggested to contribute to these cases, but the risk factors are not yet fully understood. During 2014-2015, we conducted an epidemiological study in five municipalities in Sweden, to assess whether incidents in the drinking water distribution system influence the risk of gastrointestinal illness...
June 5, 2017: Water Research
https://www.readbyqxmd.com/read/28617608/anti-ice-nucleating-activity-of-surfactants-against-silver-iodide-in-water-in-oil-emulsions
#18
Takaaki Inada, Toshie Koyama, Hiroyuki Tomita, Takuya Fuse, Chikako Kuwabara, Keita Arakawa, Seizo Fujikawa
Various water-soluble substances are known as anti-ice nucleating agents (anti-INAs), which inhibit heterogeneous ice nucleation initiated by ice nucleating agents (INAs). Among them, several surfactants are reportedly effective as anti-INAs especially against silver iodide (AgI), which is a typical inorganic INA that induces heterogeneous ice nucleation at relatively high temperatures. In this study, the anti-ice nucleating activities of seven surfactants were examined in emulsified surfactant solutions containing AgI particles...
June 28, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28613122/water-quality-and-inuit-health-an-examination-of-drinking-water-consumption-perceptions-and-contamination-in-rigolet-canada
#19
Carlee Wright
Canadian Inuit have often reported concerns about the quality of their municipal drinking water; research has also shown that some Inuit communities experience some of the highest incidence rates of self-reported acute gastrointestinal illness (AGI) in Canada and globally. The goal of this thesis research was to investigate drinking water perceptions and consumption patterns, as well as water contamination and potential associations with AGI in the Inuit community of Rigolet, Canada. Three census cross-sectional surveys captured data on AGI, drinking water, and water storage (2012-2014); additionally, bacterial contamination of household drinking water was assessed alongside the 2014 survey...
2017: International Journal of Circumpolar Health
https://www.readbyqxmd.com/read/28609620/imparting-icephobicity-with-substrate-flexibility
#20
Thomas Vasileiou, Thomas M Schutzius, Dimos Poulikakos
Ice accumulation hinders the performance of, and poses safety threats for, infrastructure both on the ground and in the air. Previously, rationally designed superhydrophobic surfaces have demonstrated some potential as a passive means to mitigate ice accretion; however, further studies on material solutions that reduce impalement and the contact time for impacting supercooled droplets (high viscosity) and can also repel droplets that freeze during surface contact are urgently needed. Here we demonstrate the collaborative effect of substrate flexibility and surface micro/nanotexture on enhancing both icephobicity and the repellency of viscous droplets (typical of supercooled water)...
June 28, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
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