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Christian Wehner, Klara Janjić, Hermann Agis
Plasmin is a proteolytic enzyme that is crucial in fibrinolysis. In oral tissues, the plasminogen system plays an essential role in physiological and pathological processes, which in addition to fibrinolysis include degradation of extracellular matrix, inflammation, immune response, angiogenesis, tissue remodeling, cell migration, and wound healing. Oral tissues reveal a change in the plasminogen system during pathological processes such as periodontitis, peri-implantitis, or pulpitis, as well as in response to mechanical load...
October 5, 2016: Archives of Oral Biology
Karla Köpke, Kerstin Prahm, Silke Buda, Walter Haas
BACKGROUND: Every year epidemic waves of influenza and other acute respiratory infections (ARIs) cause a highly variable burden of disease in the population. Thus, assessment of the situation and adaptation of prevention strategies have to rely on real time syndromic surveillance. OBJECTIVE: We have established an ICD-10-based electronic system allowing rapid capture and transmission of information on ARI (SEED(ARI)), in Germany. Here we report the evaluation of this new system based on results of the syndromic and virologic surveillance carried out by the working group on influenza in Germany (AGI)...
October 13, 2016: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
Siwar Chibani, Mouheb Chebbi, Sébastien Lebègue, Laurent Cantrel, Michael Badawi
Silver modified zeolites with a mordenite structure can capture volatile iodine compounds (I2 and ICH3) which can be released during a severe nuclear accident. However under these particular conditions, molecules such as CO and H2O present in the containment atmosphere are expected to inhibit the adsorption of iodine compounds. In the present work, periodic density functional theory calculations have been carried out to investigate the interaction of I2, ICH3, H2O and CO molecules in silver-exchanged mordenite with various Si/Al ratios with the aim of finding values that favor a selective adsorption of I2 and ICH3...
September 14, 2016: Physical Chemistry Chemical Physics: PCCP
M Jahurul Islam, D Amaranatha Reddy, Noh Soo Han, Jiha Choi, Jae Kyu Song, Tae Kyu Kim
An oxygen-vacancy rich, bismuth oxyiodide-based Z-scheme 3D hierarchical MoS2/BiOI/AgI ternary nanocomposite photocatalyst was fabricated using a simple precipitation process in ethylene glycol and water. The presence of oxygen-vacancies in BiOI and the two-dimensional nature of molybdenum disulfides in the composite prolongs the charge carrier lifetime through a Z-scheme system and enhances the performance of the photocatalyst for the degradation of rhodamine B. On the basis of efficient separation of photoexcited electron-hole pairs, a mechanism is proposed whereby MoS2 and oxygen vacancy states increase charge carrier lifetimes and improve the photocatalytic activity...
September 14, 2016: Physical Chemistry Chemical Physics: PCCP
Arnab Palui, Anirban Shaw, A Ghosh
We have studied the dynamics of silver ions in AgI-doped Ag2O-SeO2-MoO3 mixed former glasses in wide frequency and temperature ranges. We have observed that the ionic conductivity exhibits a mixed glass network former effect for low AgI content. The scaling for the conductivity spectra shows that the mechanism of charge carrier dynamics is independent of temperature and composition. We have obtained a mobile Ag(+) ion concentration from the Nernst-Einstein relation, which is found to be independent of temperature, but slightly dependent on composition...
September 21, 2016: Physical Chemistry Chemical Physics: PCCP
Ceylan Bal, Erol Rauf Ağış, Meşide Gündüzöz, Murat Büyükşekerci, Murat Alışık, Orhan Şen, Engin Tutkun, Ömer Hınç Yılmaz
Lead is a toxic heavy metal, and prevention of human exposure to lead has not been accomplished yet. The toxicity of lead is continually being investigated, and the molecular mechanisms of its toxicity are still being revealed. In this study, we used a novel method to examine thiol (SH)/disulfide homeostasis in workers who were occupationally exposed to lead. A total of 80 such workers and 70 control subjects were evaluated, and their native and total SH values were measured in serum using a novel method; their blood lead levels were also assessed...
October 3, 2016: Toxicology and Industrial Health
José Ansín Agís, Fran Ramil, Dale R Calder
One new genus (Schizoplumularia) and three new species (Schizoplumularia vervoorti, S. geniculata and S. elegans) of plumulariids are recognized and described from large collections of plumularioid hydroids collected in New Caledonia and vicinity during several French expeditions. During taxonomic studies of these hydroids, colonies were compared with type material of Plumularia insignis Allman, 1883 and several other similar species-group taxa. As a result, three of the latter (P. flabellum Allman, 1883, P...
September 19, 2016: Zootaxa
Dimitris Papamichail, Ioanna Petraki, Chrisoula Arkoudis, Agis Terzidis, Emmanouil Smyrnakis, Alexis Benos, Takis Panagiotopoulos
BACKGROUND: Research on Roma health is fragmentary as major methodological obstacles often exist. Reliable estimates on vaccination coverage of Roma children at a national level and identification of risk factors for low coverage could play an instrumental role in developing evidence-based policies to promote vaccination in this marginalized population group. METHODS: We carried out a national vaccination coverage survey of Roma children. Thirty Roma settlements, stratified by geographical region and settlement type, were included; 7-10 children aged 24-77 months were selected from each settlement using systematic sampling...
October 2, 2016: European Journal of Public Health
Stephanie A Houston, Azizah Ugusman, Sukanya Gnanadesikan, Simon Kennedy
Succinobucol is a phenolic antioxidant with anti-inflammatory and antiplatelet effects. Given the importance of oxidant stress in modulating platelet-platelet and platelet-vessel wall interactions, the aim of this study was to establish if antioxidant activity was responsible for the antiplatelet activity of succinobucol. Platelet aggregation in response to collagen and adenosine diphosphate (ADP) was studied in rabbit whole blood and platelet-rich plasma using impedance aggregometry. The effect of oxidant stress on aggregation, platelet lipid peroxides, and vascular tone was studied by incubating platelets, washed platelets or preconstricted rabbit iliac artery rings respectively with a combination of xanthine and xanthine oxidase (X/XO)...
September 29, 2016: Platelets
Honghong Chang, Jia Lv, Haochun Zhang, Bing Zhang, Wenlong Wei, Yan Qiao
Chloramphenicol (CAP) is an antibiotic used for a variety of infections, however, it is banned for use in food-producing animals due to its hazards to humans blood. Herein, the highly sensitive photoresponsive colorimetric immunoassay was exploited based on AgI/TiO2 heterojunction nanomaterials. Firstly, chitosan modified AgI/TiO2 photocatalyst (CS-AgI/TiO2) was synthesized by deposition-precipitation method, which was characterized by transmission electron microscope (TEM), scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy (EDX), X-ray powder diffraction (XRD), UV-Vis diffuse reflectance spectroscopy (DRS) and Fourier transform infrared spectroscopy (FTIR)...
September 2, 2016: Biosensors & Bioelectronics
Dongyu Xu, Bo Gao, Li Gao, Huaidong Zhou, Xingjuan Zhao, Shuhua Yin
The Three Gorges Reservoir (TGR) is the largest reservoir in China. Cadmium (Cd) is a primary pollutant in the TGR, and its speciation and bioavailability have attracted extensive attention since TGR submergence. In this study, Chelex-100 DGT (diffusive gradient in thin films) and the sequential extraction method were used to investigate the bioavailable Cd in sediments obtained from a typical tributary (Meixi) and mainstream (Yangtze) in the TGR. The total Cd concentrations in sediments of the four stations were also determined...
November 2016: Environmental Pollution
Vítor S Fernandes, Paz Recio, Elvira López-Oliva, María Pilar Martínez, Ana Sofía Ribeiro, María Victoria Barahona, Ana Cristina Martínez, Sara Benedito, Ángel Agis-Torres, Alberto Cabañero, Gemma M Muñoz, Albino García-Sacristán, Luis M Orensanz, Medardo Hernández
Hydrogen sulfide (H2S) is a gasotransmitter employed for intra- and inter-cellular communication in almost all organ systems. This study investigates the role of endogenous H2S in nerve-evoked relaxation of pig terminal bronchioles with 260 μm medium internal lumen diameter. High expression of the H2S synthesis enzyme cystathionine γ-lyase (CSE) in the bronchiolar muscle layer and strong CSE-immunoreactivity within nerve fibers distributed along smooth muscle bundles were observed. Further, endogenous H2S generated in bronchiolar membranes was reduced by CSE inhibition...
September 4, 2016: Pulmonary Pharmacology & Therapeutics
Longhao Zhang, Qiyan Chen, Ling Li, Joey S W Kwong, Pengli Jia, Pujing Zhao, Wen Wang, Xu Zhou, Mingming Zhang, Xin Sun
Alpha-glucosidase inhibitors (AGIs) was reported to be associated with several rare adverse hepatic events, but with inconsistent results. We aimed to investigate the risk of hepatotoxicity associated with the use of AGIs in patients with type 2 diabetes mellitus (T2DM), and performed a systematic review and meta-analysis. Fourteen studies (n = 2881) were eligible, all of which were RCTs. Meta-analysis of data regarding elevation of more than 3-fold the upper limit of normal (ULN) of AST and ALT showed statistically significant differences between AGIs treatment versus control (OR 6...
2016: Scientific Reports
Hong Dai, Shupei Zhang, Zhensheng Hong, Yanyu Lin
It is a great challenge to fabricate multiplex and convenient photoelectrochemical biosensors for ultrasensitive determination of biomarkers. Herein, a fascinating potentiometric addressable photoelectrochemical biosensor was reported for double biomarkers' detection by varying the applied bias in the detection process. In this biosensor, the nanocomposite of cube anatase TiO2 mesocrystals and polyamidoamine dendrimers modified a dual disk electrode as an excellent photoelectrochemical sensing matrix. Subsequently, two important biomarkers in serum for prostate cancer, prostate-specific antigen and human interleukin-6, were immobilized onto the different disks of modified electrode via glutaraldehyde bridges...
October 4, 2016: Analytical Chemistry
Guanliu Yu, Yao Wang, Shouguo Wang, Changmin Duan, Liangmeng Wei, Jing Gao, Tongjie Chai, Yumei Cai
The aim of this study was to evaluate effects of microbial aerosols on immune function of ducks and shed light on the establishment of microbial aerosol concentration standards for poultry. A total of 1800 1-d-old cherry valley ducks were randomly divided into five groups (A, B, C, D, and E) with 360 ducks in each. To obtain objective data, each group had three replications. Concentrations of airborne bacteria, fungi, endotoxin in different groups were created by controlling ventilation and bedding cleaning frequency...
2016: Frontiers in Microbiology
J Tomas-Roig, E Benito, R C Agis-Balboa, F Piscitelli, S Hoyer-Fender, V Di Marzo, U Havemann-Reinecke
Regular use of marijuana during adolescence enhances the risk of long-lasting neurobiological changes in adulthood. The present study was aimed at assessing the effect of long-term administration of the synthetic cannabinoid WIN55212.2 during adolescence in young adult mice. Adolescent mice aged 5 weeks were subjected daily to the pharmacological action of WIN55212.2 for 3 weeks and were then left undisturbed in their home cage for a 5-week period and finally evaluated by behavioral testing. Mice that received the drug during adolescence showed memory impairment in the Morris water maze, as well as a dose-dependent memory impairment in fear conditioning...
August 31, 2016: Addiction Biology
Nina Worel, Gerhard Fritsch, Hermine Agis, Alexandra Böhm, Georg Engelich, Gerda C Leitner, Klaus Geissler, Karoline Gleixner, Peter Kalhs, Veronika Buxhofer-Ausch, Felix Keil, Gerhard Kopetzky, Viktor Mayr, Werner Rabitsch, Regina Reisner, Konrad Rosskopf, Reinhard Ruckser, Claudia Zoghlami, Niklas Zojer, Hildegard T Greinix
Plerixafor in combination with granulocyte-colony stimulating factor (G-CSF) is approved for autologous stem cell mobilization in poor mobilizing patients with multiple myeloma or malignant lymphoma. The purpose of this study was to evaluate efficacy and safety of plerixafor in an immediate rescue approach, administrated subsequently to G-CSF alone or chemotherapy and G-CSF in patients at risk for mobilization failure. Eighty-five patients mobilized with G-CSF alone or chemotherapy were included. Primary endpoint was the efficacy of the immediate rescue approach of plerixafor to achieve ≥2...
August 31, 2016: Journal of Clinical Apheresis
Sh Sohrabnezhad, M Rassa, E Mohammadi Dahanesari
In this study silver halides (AgX, X=Cl, Br, I) in montmorillonite (MMT) were prepared by dispersion method in dark. AgNO3 was used as a silver precursor. The nanocomposites (NCs) (AgX-MMT) were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), and ultraviolet-visible diffuse reflectance spectroscopy (DRS). The powder X-ray diffraction showed intercalation of AgCl and AgBr nanoparticles (NPs) into the clay interlayer space. The diffuse reflectance spectra indicated a broad surface plasmon resonance (SPR) absorption band in the visible region for AgCl-MMT and AgBr-MMT NCs, resulting of metallic Ag nanoparticles (Ag NPs)...
October 2016: Journal of Photochemistry and Photobiology. B, Biology
Hongxiang Li, Dong Zhang, Yushan Wang, Shujie Zhao
PURPOSE: This prospective study investigated the association between disease severity and acute gastrointestinal injury (AGI) grade and between prognosis and AGI. METHODS: In 12 teaching hospitals in China, patients in intensive care units who had received a diagnosis of AGI were enrolled (N = 196). Their demographics, body mass index, Acute Physiology and Chronic Health Evaluation II score, Sepsis-related Organ Failure Assessment score, mechanical ventilation, acute kidney injury, intensive care unit stay, and 7-day and 28-day mortality were recorded...
May 10, 2016: Journal of Critical Care
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