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https://www.readbyqxmd.com/read/28805393/disappearance-of-the-superionic-phase-transition-in-sub-5-nm-silver-iodide-nanoparticles
#1
Takayuki Yamamoto, Hirokazu Kobayashi, Loku Singgappulige Rosantha Kumara, Osami Sakata, Kiyofumi Nitta, Tomoya Uruga, Hiroshi Kitagawa
Bulk silver iodide (AgI) is known to show a phase transition from the poorly conducting β/γ-phases into the superionic conducting α-phase at 147 °C. Its transition temperature decreases with decreasing the size of AgI, and the α-phase exists stably at 37 °C in AgI nanoparticles with a diameter of 6.3 nm. In this Letter, we investigated the atomic configuration, the phase transition behavior, and the ionic conductivity of AgI nanoparticles with a diameter of 3.0 nm. The combination of pair distribution function (PDF) analysis and reverse Monte Carlo (RMC) modeling based on high-energy X-ray diffraction (XRD) revealed for the first time that they formed the β/γ-phases with atomic disorder...
August 14, 2017: Nano Letters
https://www.readbyqxmd.com/read/28799343/the-surface-charge-distribution-affects-the-ice-nucleating-efficiency-of-silver-iodide
#2
Brittany Glatz, Sapna Sarupria
Heterogeneous ice nucleation is the primary pathway for ice formation. However, the detailed molecular mechanisms by which surfaces promote or hinder ice nucleation are not well understood. We present results from extensive molecular dynamics simulations of ice nucleation near modified silver iodide (AgI) surfaces. The AgI surfaces are modified to investigate the effects of the surface charge distribution on the rate of ice nucleation. We find that the surface charge distribution has significant effects on ice nucleation...
December 7, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28771145/waterborne-disease-outbreak-detection-an-integrated-approach-using-health-administrative-databases
#3
S Coly, N Vincent, E Vaissiere, M Charras-Garrido, A Gallay, C Ducrot, D Mouly
Hundreds of waterborne disease outbreaks (WBDO) of acute gastroenteritis (AGI) due to contaminated tap water are reported in developed countries each year. Such outbreaks are probably under-detected. The aim of our study was to develop an integrated approach to detect and study clusters of AGI in geographical areas with homogeneous exposure to drinking water. Data for the number of AGI cases are available at the municipality level while exposure to tap water depends on drinking water networks (DWN). These two geographical units do not systematically overlap...
August 2017: Journal of Water and Health
https://www.readbyqxmd.com/read/28768717/formin-2-links-neuropsychiatric-phenotypes-at-young-age-to-an-increased-risk-for-dementia
#4
Roberto Carlos Agís-Balboa, Paulo Pinhero, Nelson Rebola, Cemil Kerimoglu, Eva Benito, Michael Gertig, Sanaz Bahari-Javan, Gaurav Jain, Susanne Burkhardt, Ivana Delalle, Alexander Jatzko, Markus Dettenhofer, Patricia A Zunszain, Andrea Schmitt, Peter Falkai, Julius C Pape, Elisabeth B Binder, Christophe Mulle, Andre Fischer, Farahnaz Sananbenesi
Age-associated memory decline is due to variable combinations of genetic and environmental risk factors. How these risk factors interact to drive disease onset is currently unknown. Here we begin to elucidate the mechanisms by which post-traumatic stress disorder (PTSD) at a young age contributes to an increased risk to develop dementia at old age. We show that the actin nucleator Formin 2 (Fmn2) is deregulated in PTSD and in Alzheimer's disease (AD) patients. Young mice lacking the Fmn2 gene exhibit PTSD-like phenotypes and corresponding impairments of synaptic plasticity, while the consolidation of new memories is unaffected...
August 2, 2017: EMBO Journal
https://www.readbyqxmd.com/read/28762424/low-temperature-conductivity-and-ion-dynamics-in-silver-iodide-silver-metaphosphate-glasses
#5
Layla Badr
Silver iodide-silver metaphosphate glasses xAgI·(1 - x)AgPO3 (x = 0.3, 0.4, and 0.5) have been prepared using the usual melt quenching method. Differential scanning calorimetry has been used to determine the glass transition temperature of the samples. Impedance spectroscopy spanning wide temperature (20 K to 200 K) and frequency (10(-1) Hz to 10(6) Hz) ranges has been employed to investigate the ion dynamics. At high temperatures, below the glass transition temperature and down to around 120 K, the dynamics show the usual behavior of dc and dispersed conductivity due to the random and correlated motion of the ions...
August 16, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28745232/in-vitro-%C3%AE-glucosidase-inhibition-by-non-sugar-based-triazoles-of-dibenzoazepine-their-structure-activity-relationship-and-molecular-docking
#6
Maria A Khan, Kulsoom Javaid, Abdul Wadood, Alam Jamal, Farhana Batool, Saba Fazal-Ur-Rehman, Fatima Z Basha, M Iqbal Choudhary
BACKGROUND: α-Glucosidase inhibitors (AGIs) have been reported for their clinical potential against postprandial hyperglycemia, which is responsible for risks associated with diabetes mellitus 2 and cardiovascular diseases (CVDs). Besides, a number of compounds have been reported as potent AGIs, several side effects are associated with them. METHODS: The aim of present work is to explore new and potent molecules as AGIs. Therefore, a library of dibenzoazepine linked triazoles (1-15) was studied for their in vitro α-glucosidase inhibitory activity...
July 26, 2017: Medicinal Chemistry
https://www.readbyqxmd.com/read/28725274/news-in-al-amyloidosis-ash-2016-a%C3%A2-rapidly-evolving-field-of-investigation
#7
REVIEW
Hermine Agis
Amyloidosis is a rare but life-threatening protein misfolding disease. The early diagnosis and enrollment of patients into multicentre trials is of great importance, as is the need for intensive collaboration between multiple medical departments and experienced specialists. In the following review, the most interesting abstracts from the annual American Society of Hematology (ASH) meeting in 2016 are presented. The topics include the limitations of established biomarkers in risk assessment and response evaluation, the introduction of a new biomarker, the comparison of different treatment sequences and the efficacy of a multiple drug regimen in light-chain (AL) amyloidosis...
2017: Memo
https://www.readbyqxmd.com/read/28723559/kmt2a-and-kmt2b-mediate-memory-function-by-affecting-distinct-genomic-regions
#8
Cemil Kerimoglu, M Sadman Sakib, Gaurav Jain, Eva Benito, Susanne Burkhardt, Vincenzo Capece, Lalit Kaurani, Rashi Halder, Roberto Carlos Agís-Balboa, Roman Stilling, Hendrik Urbanke, Andrea Kranz, A Francis Stewart, Andre Fischer
Kmt2a and Kmt2b are H3K4 methyltransferases of the Set1/Trithorax class. We have recently shown the importance of Kmt2b for learning and memory. Here, we report that Kmt2a is also important in memory formation. We compare the decrease in H3K4 methylation and de-regulation of gene expression in hippocampal neurons of mice with knockdown of either Kmt2a or Kmt2b. Kmt2a and Kmt2b control largely distinct genomic regions and different molecular pathways linked to neuronal plasticity. Finally, we show that the decrease in H3K4 methylation resulting from Kmt2a knockdown partially recapitulates the pattern previously reported in CK-p25 mice, a model for neurodegeneration and memory impairment...
July 18, 2017: Cell Reports
https://www.readbyqxmd.com/read/28709443/severity-of-acute-gastrointestinal-injury-grade-is-a-predictor-of-all-cause-mortality-in-critically-ill-patients-a-multicenter-prospective-observational-study
#9
Bangchuan Hu, Renhua Sun, Aiping Wu, Yin Ni, Jingquan Liu, Feng Guo, Lijun Ying, Guoping Ge, Aijun Ding, Yunchao Shi, Changwen Liu, Lei Xu, Ronglin Jiang, Jun Lu, Ronghai Lin, Yannan Zhu, Weidong Wu, Bo Xie
BACKGROUND: In 2012, the European Society of Intensive Care Medicine proposed a definition for acute gastrointestinal injury (AGI) based on current medical evidence and expert opinion. The aim of the present study was to evaluate the feasibility of using the current AGI grading system and to investigate the association between AGI severity grades with clinical outcome in critically ill patients. METHODS: Adult patients at 14 general intensive care units (ICUs) with an expected ICU stay ≥24 h were prospectively studied...
July 14, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28709107/efficient-bacterial-inactivation-with-z-scheme-agi-bi2moo6-under-visible-light-irradiation
#10
Jialiang Liang, Fuyang Liu, Jun Deng, Mian Li, Meiping Tong
A novel Z-scheme AgI/Bi2MoO6 hybrid photocatalyst was fabricated via a solvothermal-precipitation approach to disinfect bacteria in water. Powder X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), scanning electron microscopic (SEM) equipped with energy-dispersive X-ray spectroscopy (EDX), high resolution transmission electron microscope (HRTEM), UV-vis diffuse reflectance spectra (DRS), as well as photoluminescence spectra (PL) were employed to characterize the fabricated photocatalyst. Due to the stronger redox potential and better separation of charge carriers induced by the Z-scheme structure, the optimal synthesized AgI/Bi2MoO6 exhibited excellent disinfection activity towards both Gram-negative strain Escherichia coli (E...
July 6, 2017: Water Research
https://www.readbyqxmd.com/read/28705175/serotype-specific-role-of-antigen-i-ii-in-the-initial-steps-of-the-pathogenesis-of-the-infection-caused-by-streptococcus-suis
#11
Sarah Chuzeville, Jean-Philippe Auger, Audrey Dumesnil, David Roy, Sonia Lacouture, Nahuel Fittipaldi, Daniel Grenier, Marcelo Gottschalk
Streptococcus suis is one of the most important post-weaning porcine bacterial pathogens worldwide. The serotypes 2 and 9 are often considered the most virulent and prevalent serotypes involved in swine infections, especially in Europe. However, knowledge of the bacterial factors involved in the first steps of the pathogenesis of the infection remains scarce. In several pathogenic streptococci, expression of multimodal adhesion proteins known as antigen I/II (AgI/II) have been linked with persistence in the upper respiratory tract and the oral cavity, as well as with bacterial dissemination...
July 14, 2017: Veterinary Research
https://www.readbyqxmd.com/read/28702908/water-quality-and-health-in-northern-canada-stored-drinking-water-and-acute-gastrointestinal-illness-in-labrador-inuit
#12
Carlee J Wright, Jan M Sargeant, Victoria L Edge, James D Ford, Khosrow Farahbakhsh, Inez Shiwak, Charlie Flowers, Sherilee L Harper
One of the highest self-reported incidence rates of acute gastrointestinal illness (AGI) in the global peer-reviewed literature occurs in Inuit communities in the Canadian Arctic. This high incidence of illness could be due, in part, to the consumption of contaminated water, as many northern communities face challenges related to the quality of municipal drinking water. Furthermore, many Inuit store drinking water in containers in the home, which could increase the risk of contamination between source and point-of-use (i...
July 12, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28696664/evaluation-of-silver-zeolites-sorbents-toward-their-ability-to-promote-stable-ch3i-storage-as-agi-precipitates
#13
Bruno Azambre, Mouheb Chebbi
In this study, up to 13 different silver zeolites sorbents were prepared by repeated ion exchange from their parent structures (FAU X and Y, MOR, *BEA, MFI, FER), characterized, and evaluated for their ability to capture methyl iodide in the context of a nuclear severe accident. A novel methodology was implemented to establish structure-activity relationships between sorbent properties and iodine trapping stability. After saturation of the zeolite bed with CH3I during a dynamic breakthrough experiment at 100 °C, a two-step quantitative desorption method was elaborated with the aim to quantify separately the CH3I fractions trapped by physisorption, chemisorption, or reacted as AgI precipitates...
July 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28685995/meta-analysis-and-critical-review-on-the-efficacy-and-safety-of-alpha-glucosidase-inhibitors-in-asian-and-non-asian-populations
#14
Xueying Gao, Xiaoling Cai, Wenjia Yang, Yifei Chen, Xueyao Han, Linong Ji
AIMS: To evaluate the efficacy and safety of alpha glucosidase inhibitors (AGI) in Asian and non-Asian type 2 diabetic patients. MATERIALS AND METHODS: Studies were identified through a literature search of MEDLINE, EMBASE, and other databases until December 2016. All statistical analyses were conducted in Review Manager statistical software by computing the weighted mean difference (WMD) or odds ratio (OR) and 95% confidence interval (CI). RESULTS: A total of 67 studies were included...
July 7, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28670349/epigenetic-mechanisms-during-ageing-and-neurogenesis-as-novel-therapeutic-avenues-in-human-brain-disorders
#15
REVIEW
Raúl Delgado-Morales, Roberto Carlos Agís-Balboa, Manel Esteller, María Berdasco
Ageing is the main risk factor for human neurological disorders. Among the diverse molecular pathways that govern ageing, epigenetics can guide age-associated decline in part by regulating gene expression and also through the modulation of genomic instability and high-order chromatin architecture. Epigenetic mechanisms are involved in the regulation of neural differentiation as well as in functional processes related to memory consolidation, learning or cognition during healthy lifespan. On the other side of the coin, many neurodegenerative diseases are associated with epigenetic dysregulation...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28662917/accumulative-scfv-fc-antibody-gene-integration-into-the-hprt-chromosomal-locus-of-chinese-hamster-ovary-cells
#16
Xue Wang, Yoshinori Kawabe, Risa Kato, Takeshi Hada, Akira Ito, Yoshimasa Yamana, Masako Kondo, Masamichi Kamihira
We have previously developed an accumulative site-specific gene integration system (AGIS) using Cre-recombinase and mutated loxP sites. AGIS enables repeated transgene integration into a predetermined chromosomal site in mammalian cells. However, the process of establishing cells with multiple integrated copies of the transgene is still time-consuming. In the present study, we describe an improved version of AGIS that facilitates and accelerates the establishment of high-producer Chinese hamster ovary (CHO) cells...
June 26, 2017: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/28656722/formation-of-spheroids-by-dental-pulp-derived-cells-in-the-presence-of-hypoxia-and-hypoxia-mimetic-agents
#17
K Janjić, B Lilaj, A Moritz, H Agis
AIM: To evaluate the impact of hypoxia and hypoxia mimetic agents (HMA) on the formation and activity of spheroids by dental pulp-derived cells (DPC). METHODOLOGY: DPC on agarose-coated plates were treated with hypoxia and the HMA dimethyloxallyl glycine (DMOG), desferrioxamine (DFO) and L-mimosine (L-MIM). Images of spheroids were taken directly after seeding and at 6h and 24h. Spheroid sizes were quantified by area measurement with ImageJ software. Viability was assessed with Live-Dead staining, MTT and resazurin-based toxicity assay...
June 28, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/28655919/facile-fabrication-of-nanofibrillated-chitin-ag2o-heterostructured-aerogels-with-high-iodine-capture-efficiency
#18
Runan Gao, Yun Lu, Shaoliang Xiao, Jian Li
Nanofibrillated chitin/Ag2O aerogels were fabricated for radioiodine removal. Chitin was first fabricated into nanofibers with abundant acetyl amino groups (-NHCOCH3) on the surface. Then, highly porous chitin nanofiber (ChNF) aerogels were obtained via freeze-drying. The ChNF aerogels exhibited a low bulk density of 2.19 mg/cm(3) and a high specific surface area of 179.71 m(2)/g. Ag2O nanoparticles were evenly anchored on the surfaces of ChNF scaffolds via strong interactions with -NHCOCH3 groups, subsequently yielding Ag2O@ChNF heterostructured aerogels...
June 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28654267/ternary-silver-halide-nanocrystals
#19
Sasitha C Abeyweera, Kowsalya D Rasamani, Yugang Sun
Nanocrystalline silver halides (AgX) such as AgCl, AgBr, and AgI, a class of semiconductor materials with characteristics of both direct and indirect band gaps, represent the most crucial components in traditional photographic processing. The nanocrystal surfaces provide sensitivity specks that can turn into metallic silver, forming an invisible latent image, upon exposure to light. The photographic processing implies that the AgX nanoparticles possess unique properties. First, pristine AgX nanoparticles absorb light only at low efficiency to convert surface AgX into tiny clusters of silver atoms...
June 27, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28635152/a-dna-structure-containing-ag-i-mediated-g-g-and-c-c-base-pairs
#20
Hehua Liu, Fusheng Shen, Phensinee Haruehanroengra, Qingqing Yao, Yunshan Cheng, Yiqing Chen, Chun Yang, Jing Zhang, Baixing Wu, Qiang Luo, Ruixue Cui, Jixi Li, Jinbiao Ma, Jia Sheng, Jianhua Gan
Metal-mediated base pairs have been extensively utilized in many research fields, including genetic-code extension, novel therapeutics development, and nanodevice design. Compared to other cations, Ag(I) is more flexible in pairing with natural base pairs. Herein, we present a DNA structure containing two C-Ag(I) -C pairs and the first reported G-Ag(I) -G pair in a short 8mer DNA strand. This structure not only provides detailed insight into these Ag(I) -mediated base-pairing patterns in DNA, but also represents the first nonhelical DNA structure driven by heavy-metal ions, thus further contributing to the structural diversity of DNA...
August 1, 2017: Angewandte Chemie
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