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https://www.readbyqxmd.com/read/28443627/multifunctionality-of-silver-closo-boranes
#1
Mark Paskevicius, Bjarne R S Hansen, Mathias Jørgensen, Bo Richter, Torben R Jensen
Silver compounds share a rich history in technical applications including photography, catalysis, photocatalysis, cloud seeding and as antimicrobial agents. Here we present a class of silver compounds (Ag2B10H10 and Ag2B12H12) that are semiconductors with a bandgap at 2.3 eV in the green visible light spectrum. The silver boranes have extremely high ion conductivity and dynamic-anion facilitated Ag(+) migration is suggested based on the structural model. The ion conductivity is enhanced more than two orders of magnitude at room temperature (up to 3...
April 26, 2017: Nature Communications
https://www.readbyqxmd.com/read/28435684/comparison-of-the-clinical-characteristics-and-prognosis-of-primary-versus-secondary-acute-gastrointestinal-injury-in-critically-ill-patients
#2
Dong Zhang, Rao Fu, Yanhua Li, Hongyan Li, Yuting Li, Hongxiang Li
BACKGROUND: This prospective study compared clinical characteristics and prognosis between primary (P) and secondary (S) acute gastrointestinal injury (AGI) (P-AGI)/(S-AGI) in critically ill patients. METHODS: This was a prospective, single-center observational study. Patients were included if they had been hospitalized for at least 72 h before the AGI diagnosis. Patients were classified according to severity of gastrointestinal dysfunction, while P-AGI or S-AGI were defined according to whether the gastrointestinal system was directly or indirectly involved...
2017: Journal of Intensive Care
https://www.readbyqxmd.com/read/28419698/collagen-barrier-membranes-do-not-adsorb-hypoxia-mimetic-activity-activity-of-gingival-fibroblasts-cultured-directly-on-collagen-barrier-membranes-loaded-with-hypoxia-mimetic-agents
#3
Diana Al-Habbal, Klara Janjić, Michael Edelmayer, Andreas Moritz, Hermann Agis
Hypoxia-based strategies for applications in oral surgery and periodontology have been proposed where collagen barrier membranes (CBM) are loaded with hypoxia mimetic agents (HMA) to induce a pro-angiogenic response. While it was found that CBM release HMA, it remained unclear if CBM adsorb HMA activity. Here we evaluated the response of oral cells cultured on CBM, supplemented with the HMA dimethyloxalylglycine (DMOG), desferrioxamine (DFO), and l-mimosine (l-MIM). Gingival fibroblasts (GF) were cultured on unwashed CBM as well as on CBM that had been washed with serum-free medium for 48 hours...
April 18, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28404222/the-effect-of-different-extraction-techniques-on-property-and-bioactivity-of-polysaccharides-from-dioscorea-hemsleyi
#4
Chengcheng Zhao, Xia Li, Jing Miao, Songsong Jing, Xuejiao Li, Luqi Huang, Wenyuan Gao
The rhizoma of Dioscorea hemsleyi (DH) has been used as a treatment of diabetes in China for hundreds of years. Polysaccharides in DH were extracted by using ultrasonic-assisted extraction (UAE), cold water extraction (CWE), warm water extraction (WWE) and hot water extraction (HWE), separately. Then the different characterizations of four DH polysaccharide (DHP) samples were analyzed by high-performance liquid chromatography (HPLC), high-performance Gel permeation chromatography (HGPC), ultraviolet-visible spectroscopy(UV), fourier transform-infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM)...
April 9, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28382954/early-traditional-chinese-medicine-bundle-therapy-for-the-prevention-of-sepsis-acute-gastrointestinal-injury-in-elderly-patients-with-severe-sepsis
#5
Yifei Wang, Yunhua Zhang, Ronglin Jiang
This study aimed to study the effect of early traditional Chinese medicine bundle therapy on the prevention of sepsis-associated acute gastrointestinal injury (AGI). This was a multicenter, prospective, observational, non-randomized cohort study of 296 consecutive patients with severe sepsis during 2013/3 and 2014/11; 150 patients received standard treatments (controls) and 146 received traditional Chinese medicine bundle therapy (intervention group) (herbal decoction gavage based on syndrome differentiation, Chinese acupuncture, application of mirabilite, and defecation mixture)...
April 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28376673/effect-of-prolyl-hydroxylase-inhibitor-loaded-collagen-barrier-membranes-on-osteoclastogenesis-and-osteoblastogenesis
#6
Michael Edelmayer, Diana Al-Habbal, Manuela Pensch, Klara Janjić, Hermann Agis
Prolyl hydroxylase inhibitors induce a proangiogenic response and are therefore proposed to optimize regenerative approaches in periodontics and oral surgery. Here the effect of the prolyl hydroxylase inhibitors dimethyloxalylglycine and deferoxamine, released from collagen barrier membranes, on osteoclastogenesis and osteoblastogenesis was evaluated. Collagen barrier membranes were loaded with dimethyloxalylglycine and deferoxamine. Release studies were performed and supernatants were taken after 1, 3, 6, 24, and 48 h...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28369101/risk-factors-for-gastroenteritis-associated-with-canal-swimming-in-two-cities-in-the-netherlands-during-the-summer-of-2015-a-prospective-study
#7
Rosa Joosten, Gerard Sonder, Saara Parkkali, Diederik Brandwagt, Ewout Fanoy, Lapo Mughini-Gras, Willemijn Lodder, Erik Ruland, Evelien Siedenburg, Suzanne Kliffen, Wilfrid van Pelt
Urban canal swimming events are popular in the Netherlands. In 2015, two city canal swimming events took place, in Utrecht (Utrecht Singel Swim, USS) and in Amsterdam (Amsterdam City Swim, ACS). This prospective study characterizes the health risks associated with swimming in urban waters. Online questionnaires were sent to 160 (USS) and 2,692 (ACS) participants, with relatives of participants who did not swim completing the questionnaire as a control. Swimming water specimens and stool specimens of diarrheic participants in the ACS group were analysed...
2017: PloS One
https://www.readbyqxmd.com/read/28365209/special-commentary-early-clinical-development-of-cell-replacement-therapy-considerations-for-the-national-eye-institute-audacious-goals-initiative
#8
REVIEW
Leonard A Levin, Joan W Miller, Donald J Zack, Martin Friedlander, Lois E H Smith
The National Eye Institute launched the Audacious Goals Initiative (AGI) in 2013 with the aim "to restore vision through the regeneration of neurons and neural connections in the eye and visual system." An AGI Town Hall held at the Association for Research in Vision and Ophthalmology Annual Meeting in 2016 brought together basic, translational, and clinical scientists to address the clinical implications of the AGI, with a particular emphasis on diseases amenable to regenerative medicine and strategies to deal with barriers to progess...
March 29, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28362369/monovalent-cation-doping-of-ch3nh3pbi3-for-efficient-perovskite-solar-cells
#9
Mojtaba Abdi-Jalebi, M Ibrahim Dar, Aditya Sadhanala, Satyaprasad P Senanayak, Michael Grätzel, Richard H Friend
Here, we demonstrate the incorporation of monovalent cation additives into CH3NH3PbI3 perovskite in order to adjust the optical, excitonic, and electrical properties. The possibility of doping was investigated by adding monovalent cation halides with similar ionic radii to Pb(2+), including Cu(+), Na(+), and Ag(+). A shift in the Fermi level and a remarkable decrease of sub-bandgap optical absorption, along with a lower energetic disorder in the perovskite, was achieved. An order-of-magnitude enhancement in the bulk hole mobility and a significant reduction of transport activation energy within an additive-based perovskite device was attained...
March 19, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28356059/association-between-acute-gastrointestinal-injury-and-biomarkers-of-intestinal-barrier-function-in-critically-ill-patients
#10
Hongxiang Li, Ying Chen, Feifei Huo, Yushan Wang, Dong Zhang
BACKGROUND: To assess the associations of biomarkers of intestinal barrier function and other clinical variables with acute gastrointestinal injury (AGI) grade, and of these clinical variables with mortality in critically ill patients. METHODS: This was a single-center, observational, prospective study. Patients were included if they were diagnosed with AGI and underwent tests for the measurement of plasma levels of intestinal fatty acid-binding protein (i-FABP), D-lactate (D-la), and lipopolysaccharide...
March 29, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28355949/differences-in-the-suppression-of-distortion-product-otoacoustic-emissions-by-contralateral-white-noise-between-patients-with-acute-or-chronic-tinnitus
#11
Maria Riga, Agis Komis, Pavlos Marangoudakis, Stefanos Naxakis, Eleftherios Ferekidis, Dimitrios Kandiloros, Vasilios Danielides
OBJECTIVE: The mechanisms underlying the shift from acute tinnitus to chronic remain obscure. An association between tinnitus and medial olivocochlear bundle (MOCB) reflex dysfunction has been hypothesised by several studies. The differences between participants with acute and chronic tinnitus have not yet been investigated. DESIGN: Participants were examined with distortion product otoacoustic emissions (DPOAEs) suppression elicited by contralateral white noise...
March 30, 2017: International Journal of Audiology
https://www.readbyqxmd.com/read/28350992/expression-of-circadian-core-clock-genes-in-fibroblasts-of-human-gingiva-and-periodontal-ligament-is-modulated-by-l-mimosine-and-hypoxia-in-monolayer-and-spheroid-cultures
#12
Klara Janjić, Christoph Kurzmann, Andreas Moritz, Hermann Agis
OBJECTIVE: The circadian clock is involved in a plethora of physiological processes including bone formation and tooth development. While expression of circadian core clock genes was observed in various tissues, their role in the periodontium is unclear. We hypothesized that periodontal cells express circadian core clock genes and that their levels are modulated by hypoxia mimetic agents and hypoxia. MATERIAL AND METHODS: Fibroblasts of human gingiva (GF) and periodontal ligament (PDLF) in monolayer and spheroid cultures were treated with the hypoxia mimetic agent L-Mimosine (L-MIM) or hypoxia...
March 14, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28346347/biosynthesis-of-%C3%AE-glucosidase-inhibitors-by-a-newly-isolated-bacterium-paenibacillus-sp-tku042-and-its-effect-on-reducing-plasma-glucose-in-a-mouse-model
#13
Van Bon Nguyen, Anh Dzung Nguyen, Yao-Haur Kuo, San-Lang Wang
Paenibacillus sp. TKU042, a bacterium isolated from Taiwanese soil, produced α-glucosidase inhibitors (aGIs) in the culture supernatant when commercial nutrient broth (NB) was used as the medium for fermentation. The supernatant of fermented NB (FNB) showed stronger inhibitory activities than acarbose, a commercial anti-diabetic drug. The IC50 and maximum α-glucosidase inhibitory activities (aGIA) of FNB and acarbose against α-glucosidase were 81 μg/mL, 92% and 1395 μg/mL, 63%, respectively. FNB was found to be strongly thermostable, retaining 95% of its relative activity, even after heating at 100 °C for 30 min...
March 25, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28340700/highly-photosensitive-colorimetric-immunoassay-for-tumor-marker-detection-based-on-cu-2-doped-ag-agi-nanocomposite
#14
Bing Zhang, Xue Wang, Yanling Zhao, Jia Lv, Hongyun Meng, Honghong Chang, Hui Zhang, Wenlong Wei
Visual detection of tumor markers with accuracy and selectivity exhibits significant advantages for cancer early diagnosis due to its low-cost and simple analytical instruments. Herein, a highly photosensitive colorimetric immunoassay for carcino embryonie antigen (CEA, as a model) detection based on Cu(2+) doped Ag-AgI nanocomposite was constructed. First, Cu(2+) doped Ag-AgI nanocomposite (Cu(2+)/Ag-AgI) owned the ability of oxidization of TMB was synthesized by impregnation method, which was characterized by transmission electron microscope (TEM), scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy (EDX), X-ray powder diffraction (XRD), UV-Vis diffuse reflectance spectroscopy (DRS) and X-ray photoelectron spectroscopy (XPS)...
May 15, 2017: Talanta
https://www.readbyqxmd.com/read/28337803/synthesis-electronic-structure-and-reactivities-of-two-sulfur-stabilized-carbones-exhibiting-four-electron-donor-ability
#15
Tomohito Morosaki, Ryo Iijima, Tsubasa Suzuki, Wei-Wei Wang, Shigeru Nagase, Takayoshi Fujii
Bis(sulfane)carbon(0) (BSC; Ph2S→C←SPh2 (1)) is successfully synthesized by deprotonation of the corresponding protonated salt 1·HTfO. The diprotonated salt 1·(HTfO)2 as the starting material can be also easily accessed by the deimination of iminosulfane(sulfane)carbon(0) (iSSC)·HBF4. Density functional theory calculations revealed the peculiar electronic structure of 1 having two lone pairs of electrons at the central carbon atom. The largest proton affinities (PA(1): 297.5 kcal mol-1; PA(2) 183.7 kcal mol-1) and the highest energy levels of the HOMOs (HOMO: -4...
March 23, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28336442/total-coliform-and-e-coli-in-public-water-systems-using-undisinfected-ground-water-in-the-united-states
#16
Michael J Messner, Philip Berger, Julie Javier
Public water systems (PWSs) in the United States generate total coliform (TC) and Escherichia coli (EC) monitoring data, as required by the Total Coliform Rule (TCR). We analyzed data generated in 2011 by approximately 38,000 small (serving fewer than 4101 individuals) undisinfected public water systems (PWSs). We used statistical modeling to characterize a distribution of TC detection probabilities for each of nine groupings of PWSs based on system type (community, non-transient non-community, and transient non-community) and population served (less than 101, 101-1000 and 1001-4100 people)...
March 14, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28327149/release-kinetics-and-mitogenic-capacity-of-collagen-barrier-membranes-supplemented-with-secretome-of-activated-platelets-the-in-vitro-response-of-fibroblasts-of-the-periodontal-ligament-and-the-gingiva
#17
Eva-Maria Mozgan, Michael Edelmayer, Klara Janjić, Manuela Pensch, Michael B Fischer, Andreas Moritz, Hermann Agis
BACKGROUND: Platelet preparations can stimulate the healing process and have mitogenic properties. We hypothesized that collagen barrier membranes (CBM), clinically used in guided bone regeneration and guided tissue regeneration, can serve as carriers for platelet secretome. METHODS: Secretome was generated from washed platelets and unwashed platelets (washed/unwashed PSEC) and lyophilized onto CBM. Overall appearance of CBM was evaluated by scanning electron microscopy...
March 21, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28316878/report-on-the-national-eye-institute-audacious-goals-initiative-replacement-of-retinal-ganglion-cells-from-endogenous-cell-sources
#18
Monica L Vetter, Peter F Hitchcock
This report emerges from a workshop convened by the National Eye Institute (NEI) as part of the "Audacious Goals Initiative" (AGI). The workshop addressed the replacement of retinal ganglion cells (RGCs) from exogenous and endogenous sources, and sought to identify the gaps in our knowledge and barriers to progress in devising cellular replacement therapies for diseases where RGCs die. Here, we briefly review relevant literature regarding common diseases associated with RGC death, the genesis of RGCs in vivo, strategies for generating transplantable RGCs in vitro, and potential endogenous cellular sources to regenerate these cells...
March 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/28301831/agi-nanoparticles-decorated-ceo2-microsheets-photocatalyst-for-the-degradation-of-organic-dye-and-tetracycline-under-visible-light-irradiation
#19
Xiao-Ju Wen, Cheng-Gang Niu, Min Ruan, Lei Zhang, Guang-Ming Zeng
In this paper, CeO2 microplates were synthesized by a sol-gel auto-combustion method. AgI nanoparticles (NPs) were then deposited onto the surface of CeO2 via a facile deposition-precipitation method. The as-prepared AgI/CeO2 samples were characterized by various analytical techniques. The composites exhibited superior photocatalytic activities for the organic dyes (RhB) and the refractory pollutant (tetracycline (TC), a typical antibiotic) degradation under visible light irradiation. The CA-19.03 sample exhibited the highest photocatalytic activity...
July 1, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28283801/serum-amyloid-a1-is-upregulated-in-human-glioblastoma
#20
Franciele Hinterholz Knebel, Miyuki Uno, Thais F Galatro, Luziane Potrich Bellé, Sueli Mieko Oba-Shinjo, Suely Kazue N Marie, Ana Campa
Serum amyloid A1 (SAA1) is a sensitive acute phase reactant primarily produced by the liver in response to acute inflammation. We have recently shown that SAA affects proliferation, migration, and invasion of glioblastoma cell lines, which suggest its participation in the malignant process. Consistently, levels of SAA have been used as a non-invasive biomarker for the prognosis of many cancers. In this study, we aimed to investigate SAA serum levels and expression of SAA genes in human astrocytomas tissues...
March 11, 2017: Journal of Neuro-oncology
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