Read by QxMD icon Read


Ángel Agis-Torres, Paz Recio, María Elvira López-Oliva, María Pilar Martínez, María Victoria Barahona, Sara Benedito, Salvador Bustamante, Miguel Ángel Jiménez-Cidre, Albino García-Sacristán, Dolores Prieto, Vítor S Fernandes, Medardo Hernández
Nitric oxide (NO) and hydrogen sulfide (H2 S) play a pivotal role in nerve-mediated relaxation of the bladder outflow region. In the bladder neck, a marked phosphodiesterase type 4 (PDE4) expression has also been described and PDE4 inhibitors, as rolipram, produce smooth muscle relaxation. This study investigates the role of PDE4 isoenzyme in bladder neck gaseous inhibitory neurotransmission. We used Western blot and double immunohistochemical staining for the detection of NPP4 (PDE4) and PDE4A and organ baths for isometric force recording to roflumilast and tadalafil, PDE4 and PDE5, respectively, inhibitors in pig and human samples...
March 16, 2018: Scientific Reports
Jialiang Liang, Fuyang Liu, Mian Li, Wen Liu, Meiping Tong
Magnetic Fe3 O4 @BiOI@AgI (FBA) spheres were synthesized through a multi-step process. The fabricated photocatalysts were characterized by different techniques. To testify the visible light driven photocatalytic activity of FBA, Rhodamine B and Bisphenol A were chosen as model common and emerging organic contaminants, respectively. While, gram-negative strain Escherichia coli was selected as model waterborne bacteria. The results showed that under visible light irradiation, FBA contained strong photocatalytic degradation capacity towards both RhB and BPA...
March 10, 2018: Water Research
Mohammad Kassem, Igor Alekseev, Maria Escorne-Bokova, David Le Coq, Eugene Bychkov
Conductivity isotherms of (CdTe)x (AgI)0.5- x/2 (As2Te3)0.5- x/2 glasses (0.0 ≤ x ≤ 0.15) reveal a non-monotonic behavior with increasing CdTe content reminiscent of mixed cation effect in oxide and chalcogenide glasses. Nevertheless, the apparent similarity appears to be partly incorrect. Using110m Ag tracer diffusion measurements, we show that semiconducting CdTe additions produce a dual effect: (1) decreasing the Ag+ ion transport by a factor of ≈200 with a simultaneous increase of the diffusion activation energy, and (2) increasing the electronic conductivity by 1...
March 14, 2018: Journal of Physical Chemistry. B
Klara Janjić, Barbara Cvikl, Christoph Kurzmann, Andreas Moritz, Hermann Agis
BACKGROUND: To understand the responses of the dental pulp to hypoxia is of high relevance for regenerative endodontics and dental traumatology. Here, we aimed to reveal the effects of hypoxia and the hypoxia mimetic agent L-mimosine (L-MIM) on the production of sclerostin (SOST) and dickkopf-1 (DKK-1) in human dental pulp-derived cells (DPC). METHODS: DPC in monolayer, spheroid and tooth slice cultures were treated with L-MIM or hypoxia. Resazurin-based toxicity and MTT assays were performed to determine cell viability...
March 9, 2018: BMC Oral Health
B B Li, Y Cai, Y Z Pan, M Li, Y Fang, T Tian, X M Yan
Objective: To evaluate the association between corneal biomechanical parameters and visual field (VF) progression in normal tension glaucoma (NTG) using the Corvis-ST device, and to evaluate the ability of corneal biomechanical parameters to predict the VF progression. Methods: Corneal biomechanical parameters of newly diagnosed NTG patients were obtained using Corvis-ST in the baseline follow-up visit. The VF progression was defined as a 4-point increase in the Advanced Glaucoma Intervention Study (AGIS) score compared to the baseline in three consecutive follow-up visits (per 3-6 months)...
March 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
Tomoki Yoneda, Daiki Mori, Tyuji Hoshino, Saburo Neya
A meso-aryl and β-alkyl substituted new sapphyrin 1 and its rhodium(I) and silver complexes were synthesized. Sapphyrin 1 was so stable that the non-inverted and warped structure could be analyzed by X-ray crystallography even in its neutral state. The bis-rhodium(I) comlex 1Rh2 has a more planar structure than 1 with enhanced aromaticity over the conjugation circuit. On the other hand, silver metalation into 1 caused a marked core rearrangement into neo-confused sapphyrin 1Ag with a C(α)-N bond and a twisted macrocycle...
March 7, 2018: Chemistry, An Asian Journal
Ceylan Bal, Erol R Ağış, Murat Büyükşekerci, Meşide Gündüzöz, Lütfiye Tutkun, Ömer H Yılmaz
OBJECTIVES: We designed the present study to determine the effect of occupational exposure to asphalt fumes on oxidative status and DNA damage in road paving workers. METHODS: Sixty road paving workers exposed to asphalt fumes and forty non-exposed control subjects were recruited. Occupational exposure to PAHs was assessed by urinary 1-hydroxypyrene (1-OHP) excretion. Serum thiol disulfide homeostasis (TDH), total oxidant status (TOS) and total antioxidant status (TAS) and urinary 8-hydro-deoxyguanosine (8-OH-dG) level were evaluated by automated colourimetric method...
March 7, 2018: American Journal of Industrial Medicine
David S Hersh, Sen Peng, Jimena G Dancy, Rebeca Galisteo, Jennifer M Eschbacher, Rudy J Castellani, Jonathan E Heath, Teklu Legesse, Anthony J Kim, Graeme F Woodworth, Nhan L Tran, Jeffrey A Winkles
The TNF receptor superfamily member Fn14 is overexpressed by many solid tumor types, including glioblastoma (GBM), the most common and lethal form of adult brain cancer. GBM is notable for a highly infiltrative growth pattern and several groups have reported that high Fn14 expression levels can increase tumor cell invasiveness. We reported previously that the mesenchymal and proneural GBM transcriptomic subtypes expressed the highest and lowest levels of Fn14 mRNA, respectively. Given the recent histopathological re-classification of human gliomas by the World Health Organization based on isocitrate dehydrogenase 1 (IDH1) gene mutation status, we extended this work by comparing Fn14 gene expression in IDH1 wild-type (WT) and mutant (R132H) gliomas and in cell lines engineered to overexpress the IDH1 R132H enzyme...
February 16, 2018: Journal of Neuro-oncology
Minkyung Lee, Jeong Seon Ryu, Chang Hae Suh, In Young Hyun
RATIONALE: F-fluorodeoxyglucose (F-FDG) positron emission tomography/computed tomography (PET/CT) has the potential to become an important imaging tool for the diagnosis of suspected aortoiliac bypass graft infection (AGI). PATIENT CONCERNS: A 76-year-old man presented with incidental findings of intense F-FDG activity in previous operation site of aortobiiliac bypass graft in the initial staging of small cell lung cancer (SCLC). DIAGNOSES: Based on F-FDG PET/CT examination, preliminary differential diagnosis was AGI...
February 2018: Medicine (Baltimore)
Duo Heng Cui, Yi Fan Zheng, Lin Guo Liang, Xu Chun Song
Herein, a novel visible-light-driven heterojunction AgI/WO3 nanocomposite was successfully prepared using a facile two-step hydrothermal-precipitation process and applied for photodegradation of organic pollutants. The information of phase structures, morphology, optical properties of the asprepared samples was analysed in detail by XRD, TEM, EDS, STEM, DRS measurement and so on. Formation of the heterostructure and intimate interactions between AgI and WO3 can promote highly effective photogenerated electron-hole pairs separation, which enable the heterojuctions to perform excellent photocatalytic activity as greatly enhanced photocatalysts compared to that of pristine AgI and WO3 for decomposing Rhodamine B (RhB) dye under visible light irradiation...
June 1, 2018: Journal of Nanoscience and Nanotechnology
Yuan Jiang, Mingdi Zhang, Songyi Lin, Sheng Cheng
The composition, structure, and proper positioning of amino acid in a peptide are closely related to its antioxidant activity. In this study, we purified antioxidant peptides from corn protein hydrolysates (CPH) and identified novel antioxidant peptides from fraction CPH2-III as Ala-Gly-Ile/Leu-Pro-Met (AGI/LPM; 487.62Da) and His-Ala-Ile/Leu-Gly-Ala (HAI/LGA; 467.53Da). AGLPM and HALGA exhibited better oxygen radical absorbance capacities than AGIPM and HAIGA did (P<0.05), as assessed using HepG2 cells with the cellular antioxidant activity assay (CAA) and electron spin resonance (ESR) spectroscopy...
March 2018: Food Research International
Noemi Pavo, Anna Cho, Raphael Wurm, Guido Strunk, Maria Krauth, Hermine Agis, Martin Hülsmann
BACKGROUND: Elevated levels of cardiovascular markers including N-terminal B-type natriuretic peptide (NT-proBNP) have been shown to be associated with disease severity and mortality in an unselected population of cancer patients without cardiac disease. The aim of the present study was to investigate whether NT-proBNP levels are related to disease severity in multiple myeloma (MM) and to assess the natural course of NT-proBNP levels throughout disease progression. MATERIALS AND METHODS: We retrospectively analyzed a total of 118 patients with MM, who were followed-up routinely...
February 8, 2018: European Journal of Clinical Investigation
Feng Guo, Weilong Shi, HuiBo Wang, Mumei Han, Weisheng Guan, Hui Huang, Yang Liu, Zhenhui Kang
Removal of antibiotics from aqueous solutions by photocatalysis is an advanced technology for environmental remediation. Herein, we have fabricated a series of AgX (X = I, Br)/CuBi2O4 composites through an in-situ precipitation method. The photocatalytic activity of the obtained photocatalysts was measured by the degradation of tetracycline (TC) under visible light irradiation (λ > 420 nm). All the AgX (X = I, Br)/CuBi2O4 composites exhibit much higher photocatalytic activity than that of pure CuBi2O4...
February 1, 2018: Journal of Hazardous Materials
Laurent Maron, Chen Wang, Li Xiang, Yan Yang, Jian Fang, Xuebing Leng, Yaofeng Chen
The alkylidene bridged scandium-copper/silver heterobimetallic complexes were synthesized and structurally characterized. The complexes contain different Sc-C and M-C (M = CuI, AgI) bonds. Reactivity of the scandium-copper heterobimetallic complex was also studied, which reveals that the heterobimetallic complex is a reaction intermediate for transmetalation of akylidene group from ScIII to CuI. The scandium-copper heterobimetallic complex also undergoes an addition reaction with CO, resulting in the formation of new C=C double bond...
February 7, 2018: Chemistry: a European Journal
Razieh Talebi
Multicolour photochromic behaviour in light-sensitive Ag-AgCl and Ag-AgI thin films at room temperature was investigated and compared. Although it seemed that the Ag-Ag halide thin films have similar optical properties, their optical responses to a monochromatic laser beam are completely different. It is shown that Ag-AgCl thin film changes its colour under light irradiation to the same colour of the incident light, regardless of the polarization state of the laser beam. In contrast, the Ag-AgI thin film changes to complementary colours of the incident beam...
February 7, 2018: Physical Chemistry Chemical Physics: PCCP
Mariana Dennehy, Pilar Amo-Ochoa, Eleonora Freire, Sebastián Suárez, Emilia Halac, Ricardo Baggio
Among the potential applications of coordination polymers, electrical conductivity ranks high in technological interest. We report the synthesis, crystal structure and spectroscopic analysis of an AgI-thiosaccharinate one-dimensional coordination polymer {systematic name: catena-poly[[[aquatetrakis(μ3-1,1-dioxo-1,2-benzisothiazole-3-thiolato-κ3N:S3:S3)tetrasilver(I)]-μ2-4,4'-(propane-1,3-diyl)dipyridine-κ2N:N'] dimethyl sulfoxide hemisolvate]}, {[Ag4(C7H4NO2S2)4(C13H14N2)(H2O)]·0.5C2H6OS}n, with the 4,4'-(propane-1,3-diyl)dipyridine ligand acting as a spacer...
February 1, 2018: Acta Crystallographica. Section C, Structural Chemistry
Shibaji Basak, Jens Christian Léon, Annaleizle Ferranco, Renu Sharma, Marian Hebenbrook, Alan Lough, Jens Mueller, Heinz-Bernhard Kraatz
The histidine derivative L1 of the DNA intercalator naphthalenediimide (NDI) forms a triangular AgI complex (C2). The interactions of L1 and of C2 with DNA were studied by circular dichroism (CD) and UV/vis spectroscopy and by viscosity studies. Different binding modes were observed for L1 and for C2, as the Ag complex C2 is too large in size to act as an intercalator. If AgI is added to the NDI molecule that is already intercalated into a duplex, higher order complexes are formed within the DNA duplex and cause disruptions in the helical duplex structure, which leads to a significant decrease in the characteristic CD features of B-DNA...
January 31, 2018: Chemistry: a European Journal
Patrick Schuss, Alexis Hadjiathanasiou, Dietrich Klingmüller, Ági Güresir, Hartmut Vatter, Erdem Güresir
Transsphenoidal surgery is a common procedure in patients with pituitary adenomas. Several techniques have been previously postulated to achieve sufficient sellar reconstruction to avoid cerebrospinal fluid (CSF) leakage. We analyzed our institutional database concerning two sellar reconstruction techniques and development of postoperative CSF leakage. From 2009 to 2015, 255 patients underwent transsphenoidal pituitary surgery at our institution. According to the technique used for sellar reconstruction, patients were divided into two groups: (1) with muscle patch and fibrin glue and (2) with fibrin glue alone...
February 1, 2018: Neurosurgical Review
Daniela Rodrigues-Amorim, Tania Rivera-Baltanás, Benito Regueiro, Carlos Spuch, María Elena de Las Heras, Raul Váquez-Noguerol Méndez, Maria Nieto-Araujo, C Barreiro-Villar, Jose M Olivares, Roberto C Agís-Balboa
OBJECTIVES: Schizophrenia is a poorly understood chronic disease. Its pathophysiology is complex, dynamic, and linked to epigenetic mechanisms and microbiota involvement. Nowadays, correlating schizophrenia with the environment makes sense owing, to its multidimensional implications: temporal and spatial variability. Microbiota involvement and epigenetic mechanisms are factors that are currently being considered to better understand another dimension of schizophrenia. METHODS: This review summarizes and discusses currently available information, focusing on the microbiota, epigenetic mechanisms, technological approaches aimed at performing exhaustive analyses of the microbiota, and psychotherapies, to establish future perspectives...
January 31, 2018: World Journal of Biological Psychiatry
Jungdae Park, Hee-Kyung Na, Hyun Kyong Shon, Hye Young Son, Yong-Min Huh, Sang-Won Lee, Tae Geol Lee
The development of analytical tools for accurate and sensitive detection of intracellular metabolites associated with mutated metabolic enzymes is important in cancer diagnosis and staging. The gene encoding the metabolic enzyme isocitrate dehydrogenase 1 (IDH1) is mutated in various cancers, and mutant IDH1 could represent a good biomarker and potent target for cancer therapy. Owing to a mutation in an important arginine residue in the catalytic pocket, mutant IDH1 catalyzes the production of 2-hydroxyglutarate (2-HG) instead of its wild type product α-ketoglutarate (α-KG), which is involved in multiple cellular pathways involving the hydroxylation of proteins, ribonucleic acid, and deoxyribose nucleic acid (DNA)...
January 30, 2018: Biointerphases
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"