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Tomohito Morosaki, Ryo Iijima, Tsubasa Suzuki, Wei-Wei Wang, Shigeru Nagase, Takayoshi Fujii
Bis(sulfane)carbon(0) (BSC; Ph2S→C←SPh2 (1)) is successfully synthesized by deprotonation of the corresponding protonated salt 1·HTfO. The diprotonated salt 1·(HTfO)2 as the starting material can be also easily accessed by the deimination of iminosulfane(sulfane)carbon(0) (iSSC)·HBF4. Density functional theory calculations revealed the peculiar electronic structure of 1 having two lone pairs of electrons at the central carbon atom. The largest proton affinities (PA(1): 297.5 kcal mol-1; PA(2) 183.7 kcal mol-1) and the highest energy levels of the HOMOs (HOMO: -4...
March 23, 2017: Chemistry: a European Journal
Michael J Messner, Philip Berger, Julie Javier
Public water systems (PWSs) in the United States generate total coliform (TC) and Escherichia coli (EC) monitoring data, as required by the Total Coliform Rule (TCR). We analyzed data generated in 2011 by approximately 38,000 small (serving fewer than 4101 individuals) undisinfected public water systems (PWSs). We used statistical modeling to characterize a distribution of TC detection probabilities for each of nine groupings of PWSs based on system type (community, non-transient non-community, and transient non-community) and population served (less than 101, 101-1000 and 1001-4100 people)...
March 14, 2017: International Journal of Hygiene and Environmental Health
Eva-Maria Mozgan, Michael Edelmayer, Klara Janjić, Manuela Pensch, Michael B Fischer, Andreas Moritz, Hermann Agis
BACKGROUND: Platelet preparations can stimulate the healing process and have mitogenic properties. We hypothesized that collagen barrier membranes (CBM), clinically used in guided bone regeneration and guided tissue regeneration, can serve as carriers for platelet secretome. METHODS: Secretome was generated from washed platelets and unwashed platelets (washed/unwashed PSEC) and lyophilized onto CBM. Overall appearance of CBM was evaluated by scanning electron microscopy...
March 21, 2017: BMC Oral Health
Monica L Vetter, Peter F Hitchcock
This report emerges from a workshop convened by the National Eye Institute (NEI) as part of the "Audacious Goals Initiative" (AGI). The workshop addressed the replacement of retinal ganglion cells (RGCs) from exogenous and endogenous sources, and sought to identify the gaps in our knowledge and barriers to progress in devising cellular replacement therapies for diseases where RGCs die. Here, we briefly review relevant literature regarding common diseases associated with RGC death, the genesis of RGCs in vivo, strategies for generating transplantable RGCs in vitro, and potential endogenous cellular sources to regenerate these cells...
March 2017: Translational Vision Science & Technology
Xiao-Ju Wen, Cheng-Gang Niu, Min Ruan, Lei Zhang, Guang-Ming Zeng
In this paper, CeO2 microplates were synthesized by a sol-gel auto-combustion method. AgI nanoparticles (NPs) were then deposited onto the surface of CeO2 via a facile deposition-precipitation method. The as-prepared AgI/CeO2 samples were characterized by various analytical techniques. The composites exhibited superior photocatalytic activities for the organic dyes (RhB) and the refractory pollutant (tetracycline (TC), a typical antibiotic) degradation under visible light irradiation. The CA-19.03 sample exhibited the highest photocatalytic activity...
July 1, 2017: Journal of Colloid and Interface Science
Franciele Hinterholz Knebel, Miyuki Uno, Thais F Galatro, Luziane Potrich Bellé, Sueli Mieko Oba-Shinjo, Suely Kazue N Marie, Ana Campa
Serum amyloid A1 (SAA1) is a sensitive acute phase reactant primarily produced by the liver in response to acute inflammation. We have recently shown that SAA affects proliferation, migration, and invasion of glioblastoma cell lines, which suggest its participation in the malignant process. Consistently, levels of SAA have been used as a non-invasive biomarker for the prognosis of many cancers. In this study, we aimed to investigate SAA serum levels and expression of SAA genes in human astrocytomas tissues...
March 11, 2017: Journal of Neuro-oncology
Dusan Hirjak, Robert C Wolf, Barbara Pfeifer, Ulrich Seidl, Anne K Thomann, Katharina M Kubera, Johannes Schröder, Klaus H Maier-Hein, Philipp A Thomann
BACKGROUND: Autobiographical memory (AM) is part of declarative memory and includes both semantic and episodic aspects. AM deficits are among the major complaints of patients with Alzheimer's disease (AD) even in early or preclinical stages. OBJECTIVES: Previous MRI studies AD patients have showed that deficits in semantic and episodic AM are associated with hippocampal alterations. However, the question which specific hippocampal subfields and adjacent extrahippocampal structures contribute to deficits of AM in individuals with mild cognitive impairment (MCI) and AD patients has not been investigated so far...
March 9, 2017: Hippocampus
C Knoop, M Edelmayer, K Janjić, M Pensch, M B Fischer, R Gruber, H Agis
BACKGROUND AND OBJECTIVE: In regenerative dentistry, platelet preparations are applied to stimulate bone healing and periodontal regeneration. Here, we pursue a strategy where bone substitutes are used as carriers for platelet-released supernatants. The mitogenic capacity and release kinetics of loaded bone substitutes were assessed. MATERIAL AND METHODS: Platelet-released supernatants of washed platelets (washed PRS) and platelet-released supernatants of unwashed platelets (unwashed PRS) were lyophilized onto the bone substitutes deproteinized bovine bone mineral, hydroxyapatite and β-tricalcium phosphate...
March 6, 2017: Journal of Periodontal Research
Maxime Rioux, Yannick Ledemi, Steeve Morency, Elton Soares de Lima Filho, Younès Messaddeq
In recent years, the fabrication of multifunctional fibers has expanded for multiple applications that require the transmission of both light and electricity. Fibers featuring these two properties are usually composed either of a single material that supports the different characteristics or of a combination of different materials. In this work, we fabricated (i) novel single-core step-index optical fibers made of electrically conductive AgI-AgPO3-WO3 glass and (ii) novel multimaterial fibers with different designs made of AgI-AgPO3-WO3 glass and optically transparent polycarbonate and poly (methyl methacrylate) polymers...
March 3, 2017: Scientific Reports
Wen Wu, Xiaomeng Lv, Jiaxi Wang, Jimin Xie
Using freshly prepared water-soluble KBr crystal as facile, low-cost sacrificial template, AgBr nanocubes were synthesized through one-pot precipitation method, then navy bean shaped AgI/AgBr biphasic heterostructures were synthesized through anion-exchange reaction and encased within few-layer h-BN to obtain final product. The obtained heterostructured AgI/AgBr/h-BN composite without plasmonic noble metal nanoparticles was used as stable and high active photocatalyst for dye degradation under visible light irradiation, comparing both with self-prepared normal AgBr, AgBr cubes, AgI/AgBr navy beans and other related catalysts reported in the literature...
February 22, 2017: Journal of Colloid and Interface Science
Chao-Yun Cai, Li Rao, Yong Rao, Jin-Xuan Guo, Zhi-Zun Xiao, Jing-Yu Cao, Zhi-Shu Huang, Bo Wang
Two series of compounds (chalcones and bis-chalcones) were designed, synthesized, and evaluated as α-glucosidase inhibitors (AGIs) with 1-deoxynojirimycin as positive control in vitro. Most of the compounds with two or four hydroxyl groups showed better inhibitory activities than 1-deoxynojirimycin towards α-glucosidase with noncompetitive mechanism. Moreover, most of the hydroxy bis-chalcones exhibit good α-glucosidase inhibitory activities in enzyme test. Inspiringly, bis-chalcones 2g (at 1 μM concentration) has stronger effect than 1-deoxynojirimycin on reducing the glucose level in HepG-2 cells (human liver cancer cell line)...
April 21, 2017: European Journal of Medicinal Chemistry
Barbara Cvikl, Samuel C Hess, Richard J Miron, Hermann Agis, Dieter Bosshardt, Thomas Attin, Patrick R Schmidlin, Adrian Lussi
BACKGROUND: Damage or exposure of the dental pulp requires immediate therapeutic intervention. METHODS: This study assessed the biocompatibility of a silver-containing PLGA/TCP-nanofabric scaffold (PLGA/Ag-TCP) in two in vitro models, i.e. the material adapted on pre-cultured cells and cells directly cultured on the material, respectively. Collagen saffolds with and without hyaluronan acid (Coll-HA; Coll) using both cell culturing methods and cells growing on culture plates served as reference...
February 27, 2017: BMC Oral Health
Wei Zhang, Li Zhou, Jun Shi, Huiping Deng
A visible-light-driven heterostructured AgI/g-C3N4 was prepared by a deposition-precipitation method. The composition, structure, morphology, and optical properties of the photocatalyst were characterized by Brunauer-Emmett-Teller method (BET), X-ray powder diffraction (XRD), Fourier transform-infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), transmission electron microscope (TEM), scanning electron microscope (SEM), UV-vis diffused reflectance spectroscopy (DRS), photoluminescence spectroscopy (PL), photocurrent, and electrochemical impedance spectroscopy (EIS), respectively...
February 14, 2017: Journal of Colloid and Interface Science
B C Hu, R H Sun, A P Wu, Y Ni, J Q Liu, L J Ying, Q P Xu, G P Ge, Y C Shi, C W Liu, L Xu, R H Lin, R L Jiang, J Lu, Y N Zhu, W D Wu, X J Ding, B Xie
Objective: To investigate the feasibility of utilizing the current acute gastrointestinal injury(AGI) grading system, and explore the association of severity of AGI grade with clinical outcome in critically ill patients. Methods: The adult patients from 14 general ICUs in Zhejiang Province with an expected admission to ICU for at least 24 h were recruited, and all clinical, laboratory, and survival data were prospectively collected. The AGI grade was daily assessed based on GIsymptoms, feeding details and organ dysfunctionon the first week of admission to ICU...
February 7, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Kayla M Quinnies, Erin P Harris, Rodney W Snyder, Susan S Sumner, Emilie F Rissman
Di-(2-ethylhexyl) phthalate (DEHP) is an endocrine disrupting chemical commonly used as a plasticizer in medical equipment, food packaging, flooring, and children's toys. DEHP exposure during early development has been associated with adverse neurobehavioral outcomes in children. In animal models, early exposure to DEHP results in abnormal development of the reproductive system as well as altered behavior and neurodevelopment. Based on these data, we hypothesized that developmental exposure to DEHP would decrease social interactions and increase anxiety-like behaviors in mice in a dose-dependent manner, and that the effects would persist over generations...
2017: PloS One
Richard N Besingi, Iwona B Wenderska, Dilani B Senadheera, Dennis G Cvitkovitch, Joanna R Long, Zezhang T Wen, L Jeannine Brady
Amyloids have been identified as functional components of the extracellular matrix of bacterial biofilms. Streptococcus mutans is an established etiologic agent of dental caries and biofilm dweller. In addition to the previously identified amyloidogenic adhesin P1 (aka AgI/II, PAc), we show that the naturally occurring Antigen A derivative of S. mutans wall-associated protein A (WapA), and the secreted protein SMU_63c, can also form amyloid fibrils. P1, WapA and SMU_63c were found to significantly influence biofilm development and architecture, and all three proteins were shown by immunogold electron microscopy to reside within fibrillar extracellular matrix of the biofilms...
January 28, 2017: Microbiology
A Pini, H Merk, A Carnahan, I Galanis, E VAN Straten, K Danis, M Edelstein, A Wallensten
In 2013-2014, the Public Health Agency of Sweden developed a web-based participatory surveillance system, Hӓlsorapport, based on a random sample of individuals reporting symptoms weekly online, to estimate the community incidence of self-reported acute gastrointestinal (AGI), acute respiratory (ARI) and influenza-like (ILI) illnesses and their severity. We evaluated Hӓlsorapport's acceptability, completeness, representativeness and its data correlation with other surveillance data. We calculated response proportions and Spearman correlation coefficients (r) between (i) incidence of illnesses in Hӓlsorapport and (ii) proportions of specific search terms to medical-advice website and reasons for calling a medical advice hotline...
January 31, 2017: Epidemiology and Infection
Jacek Wojaczyński, Justyna Maciołek, Piotr J Chmielewski
A fully conjugated system 4 consisting of two 2-aza-21-carbaporphyrin (NCP) subunits bridged by dipyrrin was synthesized by a highly selective condensation of 3-pyrrole-NCP 2 with aryl aldehydes. The free base 4 as well as its silver(III) complex 5 exhibited flexibility of the bridge allowing synergetic binding of Ag(I) , thus leading to a mixed-valence tetraporphyrinic assembly consisting of eight silver atoms which was characterized both in the solid state and in solution. Binding of chiral acid by 4 and 5 was shown by observation of an induced optical activity of the adducts...
January 30, 2017: Chemistry, An Asian Journal
Jennifer Pettersson, Alireza Daryapeyma, Peter Gillgren, Rebecka Hultgren
BACKGROUND: Aortic graft infections (AGI) are rare, with an incidence of 0.6%-3% among patients with aortic grafts. Most previous reports are based on single-center material with limited follow-up. Because of the paucity of these cases, the optimal treatment remains unclear. A factor possibly affecting the mortality rate of these infections is whether the index procedure was emergency or elective. The aim of this study was to investigate the incidence of AGI and assess the long-term outcome after emergency and non-emergency aortic reconstruction in a large population...
January 27, 2017: Surgical Infections
Azam Bolhassani, Noushin Davoudi, Elnaz Agi, Fatemeh Motevalli
Virus-like particles (VLPs) could be improved into successful immunogens as well as a potent delivery vehicle, but however, the current expression systems for VLPs production have some limitations. Recently, we developed a novel strategy to produce two HCV VLPs containing core or coreE1E2 proteins using stably transfected Leishmania tarentolae promastigotes. Then, BALB/c mice were injected by both viral like particles in different immunization strategies such as homologous DNA-, homologous VLP-, and heterologous DNA/ VLP-based immunizations...
January 25, 2017: Current Drug Delivery
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