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Neuroglobin

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https://www.readbyqxmd.com/read/28428250/functional-roles-of-globin-proteins-in-hypoxia-tolerant-ectothermic-vertebrates
#1
Angela Fago
Globins are heme-containing proteins ubiquitously expressed in vertebrates, where they serve a broad range of biological functions, directly or indirectly related to the tight control of oxygen levels and its toxic products in vivo. Perhaps the most investigated of all proteins, hemoglobin and myoglobin are primarily involved in oxygen transport and storage, but also in facilitating arterial vasodilation, suppressing mitochondrial respiration and preventing tissue oxidative damage via accessory redox enzymatic activities during hypoxia...
April 20, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28410531/tumor-grade-related-expression-of-neuroglobin-is-negatively-regulated-by-ppar%C3%AE-and-confers-antioxidant-activity-in-glioma-progression
#2
Jing Hu, Xiyue Cao, Dejiang Pang, Qihui Luo, Yuanfeng Zou, Bin Feng, Lixia Li, Zhengli Chen, Chao Huang
Neuroglobin (NGB), distributed mainly in central and peripheral nervous systems, is a nerve globin with neuroprotective effects against oxidative stress resulting from hypoxia and ischemia. Recent studies have indicated that the expression of NGB is related to neurodegenerative disorders and cancers, but the molecular mechanisms for its transcriptional regulation and protection are not well defined. Here, we report that the expression of NGB in glioma is grade related and is negatively regulated by PPARγ. Specific PPARγ agonist reduces the expression of NGB, while its inhibitor enhances the expression...
April 1, 2017: Redox Biology
https://www.readbyqxmd.com/read/28378164/computational-evidence-support-the-hypothesis-of-neuroglobin-also-acting-as-an-electron-transfer-species
#3
Licia Paltrinieri, Giulia Di Rocco, Gianantonio Battistuzzi, Marco Borsari, Marco Sola, Antonio Ranieri, Laura Zanetti-Polzi, Isabella Daidone, Carlo Augusto Bortolotti
Neuroglobin (Ngb) is a recently identified hexa-coordinated globin, expressed in the nervous system of humans. Its physiological role is still debated: one hypothesis is that Ngb serves as an electron transfer (ET) species, possibly by reducing cytochrome c and preventing it to initiate the apoptotic cascade. Here, we use the perturbed matrix method (PMM), a mixed quantum mechanics/molecular dynamics approach, to investigate the redox thermodynamics of two neuroglobins, namely the human Ngb and GLB-6 from invertebrate Caenorhabditis elegans...
April 4, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28359933/recombinant-human-erythropoietin-offers-neuroprotection-through-inducing-endogenous-erythropoietin-receptor-and-neuroglobin-in-a-neonatal-rat-model-of-periventricular-white-matter-damage
#4
Lihua Zhu, Li Huang, Quan Wen, Ting Wang, Lixing Qiao, Li Jiang
Recombinant human erythropoietin (rh-EPO) has been reported to have protective effects against brain injury. The purpose of this study was to evaluate the levels of erythropoietin receptor (EPOR) and neuroglobin (Ngb) in a neonatal rat model of periventricular white matter damage (PWMD), and to identify the relationship between the two proteins. On postnatal day 3 (P3), rats underwent permanent ligation of the right common carotid artery followed by 6% O2 for 4h (HI) or sham operation and normoxic exposure (sham)...
March 27, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28332151/blockade-of-neuroglobin-reduces-protection-of-conditioned-medium-from-human-mesenchymal-stem-cells-in-human-astrocyte-model-t98g-under-a-scratch-assay
#5
Eliana Baez-Jurado, Gina Guio Vega, Gjumrakch Aliev, Vadim V Tarasov, Paula Esquinas, Valentina Echeverria, George E Barreto
Previous studies have indicated that paracrine factors (conditioned medium) increase wound closure and reduce reactive oxygen species in a traumatic brain injury in vitro model. Although the beneficial effects of conditioned medium from human adipose tissue-derived mesenchymal stem cells (hMSCA-CM) have been previously suggested for various neurological diseases, their actions on astrocytic cells are not well understood. In this study, we have explored the effect of hMSCA-CM on human astrocyte model (T98G cells) subjected to scratch assay...
March 22, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28320188/clinical-significance-of-changes-in-serum-neuroglobin-and-hif-1%C3%AE-concentrations-during-the-early-phase-of-acute-ischemic-stroke
#6
Lixia Xue, Hao Chen, Kaili Lu, Jiankang Huang, Hao Duan, Yuwu Zhao
BACKGROUND: Neuroglobin (NGB) has been described as a neuroprotective agent in cerebral ischemia, hypoxia inducible factor (HIF) has shown an important role in modulating hypoxic and ischemic injury, and therefore they have the potential to impact outcomes after acute ischemic stroke (AIS). Thus, we investigated early changes in the concentrations of serum NGB and HIF-1α after AIS and evaluated the relations of both NGB and HIF-1α to stroke severity and prognosis. METHODS: We prospectively measured the serum concentrations of NGB and HIF-1α in 40 patients with AIS at 24, 48, 72, and 96h after stroke...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28316021/hemin-protects-against-oxygen-glucose-deprivation-induced-apoptosis-activation-via-neuroglobin-in-sh-sy5y-cells
#7
Yun-Jia Wang, Qian-Yi Peng, Song-Yun Deng, Cai-Xia Chen, Long Wu, Li Huang, Li-Na Zhang
This study aimed to investigate the mechanism underlying the neuroprotective effect of hemin in oxygen-glucose deprivation (OGD)-treated neurons. OGD-treated SH-SY5Y cells (human neuroblastoma cells) were used in the study. The cellular viability of SH-SY5Y cells was assessed by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, and the cell apoptosis rate was determined by flow cytometry analysis with Annexin V-fluorescein isothiocyanate and propidium iodide staining with or without hemin pretreatment...
March 18, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28293020/untangling-the-relationship-between-diet-and-visceral-fat-mass-through-blood-metabolomics-and-gut-microbiome-profiling
#8
T Pallister, M A Jackson, T C Martin, C A Glastonbury, A Jennings, M Beaumont, R P Mohney, K S Small, A MacGregor, C J Steves, A Cassidy, T D Spector, C Menni, A M Valdes
BACKGROUND/OBJECTIVES: Higher visceral fat mass (VFM) is associated with an increased risk for developing cardio-metabolic diseases. The mechanisms by which an unhealthy diet pattern may influence VF development has yet to be examined through cutting-edge multi-omic methods. Therefore, our objective was to examine the dietary influences on VFM and identify gut microbiome and metabolite profiles that link food intakes to VFM. SUBJECTS/METHODS: In 2218 twins with VFM, food intake and metabolomics data available we identified food intakes most strongly associated with VFM in 50% of the sample, then constructed and tested the 'VFM diet score' in the remainder of the sample...
March 15, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28246171/a-distal-ligand-mutes-the-interaction-of-hydrogen-sulfide-with-human-neuroglobin
#9
Markus Ruetz, Jacques Kumutima, Brianne E Lewis, Milos R Filipovic, Nicolai Lehnert, Timothy L Stemmler, Ruma Banerjee
Hydrogen sulfide is a critical signaling molecule, but high concentrations cause cellular toxicity. A four-enzyme pathway in the mitochondrion detoxifies H2S by converting it to thiosulfate and sulfate. Recent studies have shown that globins like hemoglobin and myoglobin can also oxidize H2S to thiosulfate and hydropolysulfides. Neuroglobin, a globin enriched in the brain, was reported to bind H2S tightly and was postulated to play a role in modulating neuronal sensitivity to H2S in conditions such as stroke...
April 21, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28193153/molecular-evolution-of-globin-genes-in-gymnotiform-electric-fishes-relation-to-hypoxia-tolerance
#10
Ran Tian, Mauricio Losilla, Ying Lu, Guang Yang, Harold Zakon
BACKGROUND: Nocturnally active gymnotiform weakly electric fish generate electric signals for communication and navigation, which can be energetically taxing. These fish mainly inhabit the Amazon basin, where some species prefer well-oxygenated waters and others live in oxygen-poor, stagnant habitats. The latter species show morphological, physiological, and behavioral adaptations for hypoxia-tolerance. However, there have been no studies of hypoxia tolerance on the molecular level. Globins are classic respiratory proteins...
February 13, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/28103511/neuroglobin-functions-as-a-prognostic-marker-and-promotes-the-tumor-growth-of-glioma-via-suppressing-apoptosis
#11
Bei Zhang, Mingze Chang, Juanhong Wang, Yong Liu
Neuroglobin (Ngb) has been reported to be upregulated by hypoxia and plays an anti-apoptotic function. Previous studies have reported that Ngb is expressed in human glioblastoma cells and up-regulated in hypoxic microregions of glioblastoma tumor xenografts. While, the clinical significance of Ngb and its function in human glioma keep unknown. Ngb expression was analyzed in 86 glioma tissues and 20 normal brain tissues. Results showed that Ngb was significantly overexpressed in glioma tissues compared to normal brain tissues...
April 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28056323/-the-role-of-neuroglobin-in-oxygen-glucose-deprivation-and-reoxygenation-induced-mitochondrial-depolarization-and-reactive-oxygen-species-production-in-sh-sy5y-cells
#12
S Y Deng, Y H Ai, L N Zhang, L Wu, C X Chen, Y M Wang, Z Y Liu, L Huang, Q Y Peng
Objective: To investigate the role of neuroglobin (NGB) in oxygen-glucose deprivation and reoxygenation (OGD/R) induced mitochondrial depolarization and reactive oxygen species (ROS)production in a human neuroblastoma cell line (SH-SY5Y). Methods: SH-SY5Y cells were transfected with lentivirus to establish a stable cell line of NGB knockdown (KD). After treated with OGD/R, cells were collected at different time points to analyze NGB mRNA and protein levels. Furthermore, cells were stained with JC-1 and DCFH-DA to evaluate mitochondrial depolarization and ROS production by inverted fluorescence microscope...
January 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/27957684/huntingtin-polyq-mutation-impairs-the-17%C3%AE-estradiol-neuroglobin-pathway-devoted-to-neuron-survival
#13
Maria Teresa Nuzzo, Marco Fiocchetti, Pierangela Totta, Mariarosa A B Melone, Antonella Cardinale, Francesca R Fusco, Stefano Gustincich, Francesca Persichetti, Paolo Ascenzi, Maria Marino
Among several mechanisms underlying the well-known trophic and protective effects of 17β-estradiol (E2) in the brain, we recently reported that E2 induces the up-regulation of two anti-apoptotic and neuroprotectant proteins: huntingtin (HTT) and neuroglobin (NGB). Here, we investigate the role of this up-regulation. The obtained results indicate that E2 promotes NGB-HTT association, induces the localization of the complex at the mitochondria, and protects SK-N-BE neuroblastoma cells and murine striatal cells, which express wild-type HTT (i...
December 12, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27951646/phe28-b10-induces-channel-forming-cytotoxic-amyloid-fibrillation-in-human-neuroglobin-the-brain-specific-hemoglobin
#14
Sheetal Uppal, Amit Kumar Singh, Richa Arya, Debanjan Tewari, Neha Jaiswal, Abhijeet Kapoor, Amal Kanti Bera, Alo Nag, Suman Kundu
Since its discovery, neuroglobin (Ngb), a neuron-specific oxygen binding hemoglobin, distinct from the classical myoglobin and blood hemoglobin, has attracted attention as an endogenous neuroprotectant. Recent reports suggest that Ngb protects neurons from brain stroke, ischemic stress-induced degeneration, and other brain disorders. Proteins with a specific role in neuroprotection are often associated with neurodegeneration, as well, depending on the cellular environment or specific cellular triggers that tilt the balance one way or the other...
December 13, 2016: Biochemistry
https://www.readbyqxmd.com/read/27928027/five-coordinate-h64q-neuroglobin-as-a-ligand-trap-antidote-for-carbon-monoxide-poisoning
#15
Ivan Azarov, Ling Wang, Jason J Rose, Qinzi Xu, Xueyin N Huang, Andrea Belanger, Ying Wang, Lanping Guo, Chen Liu, Kamil B Ucer, Charles F McTiernan, Christopher P O'Donnell, Sruti Shiva, Jesús Tejero, Daniel B Kim-Shapiro, Mark T Gladwin
Carbon monoxide (CO) is a leading cause of poisoning deaths worldwide, with no available antidotal therapy. We introduce a potential treatment paradigm for CO poisoning, based on near-irreversible binding of CO by an engineered human neuroglobin (Ngb). Ngb is a six-coordinate hemoprotein, with the heme iron coordinated by two histidine residues. We mutated the distal histidine to glutamine (H64Q) and substituted three surface cysteines with less reactive amino acids to form a five-coordinate heme protein (Ngb-H64Q-CCC)...
December 7, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27867483/brain-globins-in-physiology-and-pathology
#16
REVIEW
Luo-Kun Xie, Shao-Hua Yang
Globins are globular proteins for either transport or storage of oxygen which are critical for cellular metabolism. Four globins have been identified in rodent and human brains. Among them, neuroglobin, cytoglobin and hemoglobin chains are constitutively expressed in normal brain, while myoglobin is only expressed in some neurological disorders. Studies on the molecular structure, expression and functional features of these brain globins indicated that they may play crucial roles in maintenance of neural cell survival and activity, including neurons and astrocytes...
July 2016: Medical Gas Research
https://www.readbyqxmd.com/read/27852417/-influences-of-dna-methylation-upon-neuroglobin-sustained-expression-in-oxygen-glucose-deprivation-model
#17
L N Zhang, S B Hu, S Y Deng, C X Chen, L Wu, Q Y Peng, L Huang, Y H Ai
Objective: To investigate the influences of genomic DNA methylation upon neuroglobin sustained expression in oxygen- glucose deprivation model. Methods: With A549 cell strain as the research object, the control group were cultivated in the complete medium containing 10 μmol/L of 5-azacytidine for 4 days, and the control group was cultivated in the complete medium for 4 days.Then carried out oxygen glucose deprivation treatment for 4 h.Detecting neuroglobin expression, DNA methyltransferase expression, cell inhibition ratio and DNA methylation level at different time points...
October 25, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27825818/neuroglobin-from-structure-to-function-in-health-and-disease
#18
REVIEW
Paolo Ascenzi, Alessandra di Masi, Loris Leboffe, Marco Fiocchetti, Maria Teresa Nuzzo, Maurizio Brunori, Maria Marino
In 2000, the third member of the globin family was discovered in human and mouse brain and named neuroglobin (Ngb). Ngb is a monomeric 3/3 globin structurally similar to myoglobin and to the α- and β-chains of hemoglobin, however it displays a bis-histidyl six-coordinate heme-Fe atom. Therefore, ligand binding to the Ngb metal center is limited from the dissociation of the distal His(E7)64-Fe bond. From its discovery, more than 500 papers on Ngb structure, expression, reactivity, and localization have been published to highlight its biochemical properties and its role(s) in health and disease...
December 2016: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/27809238/neuroglobin-a-factor-playing-for-nerve-cell-survival
#19
REVIEW
Diego Guidolin, Cinzia Tortorella, Manuela Marcoli, Guido Maura, Luigi F Agnati
Cell death represents the final outcome of several pathological conditions of the central nervous system and available evidence suggests that in both acute injuries and neurodegenerative diseases it is often associated with mitochondrial dysfunction. Thus, the possibility to prevent mitochondrial events involved in cell death might represent efficient tools to limit neuronal damage. In recent years, increased attention has been paid to the endogenous protein neuroglobin, since accumulating evidence showed that its high expression was associated with preserved mitochondrial function and to an increased survival of nerve cells in vitro and in vivo in a variety of experimental models of cell insult...
October 31, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27787886/neuroglobin-protects-astroglial-cells-from-hydrogen-peroxide-induced-oxidative-stress-and-apoptotic-cell-death
#20
Fatma Amri, Ikram Ghouili, Mohamed Amri, Alice Carrier, Olfa Masmoudi-Kouki
Oxidative stress, resulting from accumulation of reactive oxygen species, plays a critical role in astroglial cell death occurring in diverse neuropathological conditions. Numerous studies indicate that neuroglobin (Ngb) promotes neuron survival, but nothing is known regarding the action of Ngb in astroglial cell survival. Thus, the purpose of this study was to investigate the potential glioprotective effect of Ngb on hydrogen peroxide (H2 O2 )-induced oxidative stress and apoptosis in cultured mouse astrocytes...
January 2017: Journal of Neurochemistry
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