keyword
MENU ▼
Read by QxMD icon Read
search

Neuroglobin

keyword
https://www.readbyqxmd.com/read/29141514/regulatory-effect-of-neuroglobin-in-the-recovery-of-spinal-cord-injury
#1
Ji-Lin Dai, Yun Lin, Yong-Jian Yuan, Shi-Tong Xing, Yi Xu, Qiang-Hua Zhang, Ji-Kang Min
OBJECTIVE: The present study was aimed to investigate the therapeutic potential of neuroglobin in the recovery of spinal cord injury. METHODS: The male albino Wistar strain rats were used as an experimental model, and adeno associated virus (AAV) was administered in the T12 section of spinal cord ten days prior to the injury. Basso Beattie Bresnahan (BBB) locomotor rating scale was used to determine the recovery of the hind limb during four weeks post-operation...
November 16, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29108649/mapping-hydrophobic-tunnels-and-cavities-in-neuroglobin-with-noble-gas-under-pressure
#2
Nathalie Colloc'h, Philippe Carpentier, Laura C Montemiglio, Beatrice Vallone, Thierry Prangé
Internal cavities are crucial for conformational flexibility of proteins and can be mapped through noble gas diffusion and docking. Here we investigate the hydrophobic cavities and tunnel network in neuroglobin (Ngb), a hexacoordinated heme protein likely to be involved in neuroprotection, using crystallography under noble gas pressure, mostly at room temperature. In murine Ngb, a large internal cavity is involved in the heme sliding mechanism to achieve binding of gaseous ligands through coordination to the heme iron...
November 3, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/29101592/localization-of-neuroglobin-in-the-brain-of-r6-2-mouse-model-of-huntington-s-disease
#3
A Cardinale, F R Fusco, E Paldino, C Giampà, M Marino, M T Nuzzo, V D'Angelo, D Laurenti, G Straccia, D Fasano, D Sarnataro, T Squillaro, S Paladino, Mariarosa A B Melone
Neuroglobin (Ngb) is expressed in the central and peripheral nervous system, cerebrospinal fluid, retina, and endocrine tissues where it is involved in binding O2 and other gasotransmitters. Several studies have highlighted its endogenous neuroprotective function. Huntington's disease (HD), a dominant hereditary disease, is characterized by the gradual loss of neurons in discrete areas of the central nervous system. We analyzed the expression of Ngb in the brain tissue of a mouse model of HD, in order to define the role of Ngb with respect to individual cell type vulnerability in HD and to gender and age of mice...
November 3, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29098407/cytoprotective-effects-of-transgenic-neuroglobin-overexpression-in-an-acute-and-chronic-mouse-model-of-ischemic-heart-disease
#4
Evi Luyckx, Bert R Everaert, Bieke Van der Veken, Wendy Van Leuven, Jean-Pierre Timmermans, Christiaan J Vrints, Guido R Y De Meyer, Wim Martinet, Sylvia Dewilde
Neuroglobin (NGB) is an oxygen-binding protein that is mainly expressed in nervous tissues where it is considered to be neuroprotective during ischemic brain injury. Interestingly, transgenic mice overexpressing NGB reveal cytoprotective effects on tissues lacking endogenous NGB, which might indicate a therapeutic role for NGB in a broad range of ischemic conditions. In the present study, we investigated the effect of NGB overexpression on survival as well as on the size and occurrence of myocardial infarctions (MI) in a mouse model of acute MI (AMI) and a model of advanced atherosclerosis (ApoE (-/-) Fbn1 (C1039G+/-) mice), in which coronary plaques and MI develop in mice being fed a Western-type diet...
November 2, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/29094190/evolution-of-single-domain-globins-in-hydrothermal-vent-scale-worms
#5
J Projecto-Garcia, A-S Le Port, T Govindji, D Jollivet, S W Schaeffer, S Hourdez
Hypoxia at deep-sea hydrothermal vents represents one of the most basic challenges for metazoans, which then requires specific adaptations to acquire oxygen to meet their metabolic needs. Hydrothermal vent scale-worms (Polychaeta; Polynoidae) express large amounts of extracellular single- and multi-domain hemoglobins, in contrast with their shallow-water relatives that only possess intracellular globins in their nervous system (neuroglobins). We sequenced the gene encoding the single-domain (SD) globin from nine species of polynoids found in various vent and deep-sea reduced microhabitats (and associated constraints) to determine if the Polynoidae SD globins have been the targets of diversifying selection...
November 1, 2017: Journal of Molecular Evolution
https://www.readbyqxmd.com/read/29078150/the-influence-of-the-cys46-cys55-disulfide-bond-on-the-redox-and-spectroscopic-properties-of-human-neuroglobin
#6
Marzia Bellei, Carlo Augusto Bortolotti, Giulia Di Rocco, Marco Borsari, Lidia Lancellotti, Antonio Ranieri, Marco Sola, Gianantonio Battistuzzi
Neuroglobin is a monomeric globin containing a six-coordinate heme b, expressed in the nervous system, which exerts an important neuroprotective role. In the human protein (hNgb), Cys46 and Cys55 form an intramolecular disulfide bond under oxidizing conditions, whose cleavage induces a helix-to-strand rearrangement of the CD loop that strengthens the bond between the heme iron and the distal histidine. Hence, it is conceivable that the intramolecular disulfide bridge modulates the functionality of human neuroglobin by controlling exogenous ligand binding...
October 16, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29075122/adeno-associated-virus-mediated-neuroglobin-overexpression-ameliorates-the-n-methyl-n-nitrosourea-induced-retinal-impairments-a-novel-therapeutic-strategy-against-photoreceptor-degeneration
#7
Ye Tao, Zhen Yang, Wei Fang, Zhao Ma, Yi Fei Huang, Zhengwei Li
Retinal degeneration (RD) is a heterogeneous group of inherited dystrophies leading to blindness. The N-methyl-N-nitrosourea (MNU)-administered mouse is used as a pharmacologically induced RD animal model in various therapeutic investigations. The present study found the retinal neuroglobin (NGB) expression in the MNU-administered mice was significantly lower than in normal controls, suggesting NGB was correlated with RD. Subsequently, an adeno-associated virus (AAV)-2-mCMV-NGB vector was delivered into the subretinal space of the MNU-administered mice...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29038003/hemin-supports-the-survival-of-photoreceptors-injured-by-n-methyl-n-nitrosourea-the-contributory-role-of-neuroglobin-in-photoreceptor-degeneration
#8
Ye Tao, Zhao Ma, Bei Liu, Wei Fang, Limin Qin, Yi Fei Huang, Lu Wang, Yanling Gao
Retina is a critical component of the central nerve system that is responsible for the conversion of light stimulus into electrical spikes. Retinitis pigmentosa (RP) comprises a heterogeneous group of inherited retinal dystrophies leading to blindness. We examined retinal neuroglobin (Ngb) expression in a pharmacologically induced RP animal model, the N-Methyl-N-nitrosourea (MNU) administered mice. The retinal Ngb expression in MNU administered mice attenuated following a time dependent manner, suggesting Ngb was involved in the photoreceptor degeneration...
October 13, 2017: Brain Research
https://www.readbyqxmd.com/read/29031607/hearing-without-neuroglobin
#9
Manuela Nowotny, Lenneke Kiefer, Daniel Andre, Andrej Fabrizius, Thomas Hankeln, Stefan Reuss
Neuroglobin (Ngb) is a member of the globin family of respiratory proteins, which was recently observed in many neurons of the auditory pathways. Up to now, however, nothing was known about the role of Ngb in hearing processes. We therefore studied auditory function by recording distortion-product otoacoustic emissions (DPOAE) and auditory brainstem responses (ABRs) in wild-type (C57BL/6N) and Ngb-knockout mice. In KO mice, DPOAE thresholds were moderately augmented in the range of 5-18 kHz, reaching statistical significance at 8 and 10 kHz, while the ABR thresholds were not different between groups...
October 13, 2017: Neuroscience
https://www.readbyqxmd.com/read/28951213/a-novel-function-of-neuroglobin-for-neuroregeneration-in-mice-after-optic-nerve-injury
#10
Kayo Sugitani, Yoshiki Koriyama, Mayuko Sera, Kunizo Arai, Kazuhiro Ogai, Keisuke Wakasugi
Neuroglobin (Ngb) is a recently discovered heme protein in the vertebrate brain that can bind to oxygen molecules. Mammalian Ngb plays a crucial role in neuroprotection under conditions of oxidative stress. To investigate other potential functions of Ngb, we investigated the mouse retinal Ngb system following optic nerve injury. In the retina of control mice, Ngb immunoreactivity was limited to the retinal ganglion cell (RGC) layer, and this immunoreactivity rapidly decreased to less than 50% of the control level 5 days after optic nerve injury...
November 25, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28948468/tibolone-reduces-oxidative-damage-and-inflammation-in-microglia-stimulated-with-palmitic-acid-through-mechanisms-involving-estrogen-receptor-beta
#11
Oscar Hidalgo-Lanussa, Marco Ávila-Rodriguez, Eliana Baez-Jurado, Jairo Zamudio, Valentina Echeverria, Luis Miguel Garcia-Segura, George E Barreto
High concentrations of palmitic acid in plasma increase both the inflammation associated with obesity and the susceptibility to develop a neurodegenerative event. In the brain, the inflammatory response is mediated by activated microglial cells, which undergo morphological and biochemical changes and can directly affect cell viability. Recent evidence shows that the use of estrogenic compounds can control microglia-induced inflammation with promising results. In this study, we explored the actions of the synthetic steroid tibolone on BV-2 microglia cells stimulated with palmitic acid...
September 25, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28929379/erratum-to-anatomical-specificity-of-the-brain-in-the-modulation-of-neuroglobin-and-cytoglobin-genes-after-chronic-bisphenol-a-exposure
#12
Rodrigo Rodrigues da Conceição, Janaina Sena de Souza, Kelen Carneiro de Oliveira, Rui Monteiro de Barros Maciel, Marco Aurélio Romano, Renata Marino Romano, Magnus Régios Dias da Silva, Maria Izabel Chiamolera, Gisele Giannocco
No abstract text is available yet for this article.
December 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28918749/effect-of-low-temperature-on-globin-expression-respiratory-metabolic-enzyme-activities-and-gill-structure-of-litopenaeus-vannamei
#13
Meng Wu, Nan Chen, Chun-Xiao Huang, Yan He, Yong-Zhen Zhao, Xiao-Han Chen, Xiu-Li Chen, Huan-Ling Wang
Low temperature frequently influences growth, development, and even survival of aquatic animals. In the present study, physiological and molecular responses to low temperature in Litopenaeus vannamei were investigated. The cDNA sequences of two oxygen-carrying proteins, cytoglobin (Cygb) and neuroglobin (Ngb), were isolated. Protein structure analysis revealed that both proteins share a globin superfamily domain. Real-time PCR analysis indicated that Cygb and Ngb mRNA levels gradually increased during decrease in temperatures from 25 to 15°C and then decreased at 10°C in muscle, brain, stomach, and heart, except for a continuing increase in gills, whereas they showed a different expression trend in the hepatopancreas...
July 2017: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/28904863/chimeric-zhhh-neuroglobin-acts-as-a-cell-membrane-penetrating-inducer-of-neurite-outgrowth
#14
Nozomu Takahashi, Wataru Onozuka, Seiji Watanabe, Keisuke Wakasugi
Neuroglobin (Ngb) is a heme protein expressed in the vertebrate brain. We previously engineered a chimeric Ngb protein, in which module M1 of human Ngb is replaced by that of zebrafish Ngb, and showed that the chimeric ZHHH Ngb has a cell membrane-penetrating activity similar to that of zebrafish Ngb and also rescues cells from death caused by hypoxia/reoxygenation as does human Ngb. Recently, it was reported that overexpression of mammalian Ngb in neuronal cells induces neurite outgrowth. In this study, we performed neurite outgrowth assays of chimeric Ngb using rat pheochromocytoma PC12 cells...
September 2017: FEBS Open Bio
https://www.readbyqxmd.com/read/28880206/comparative-response-of-brain-to-chronic-hypoxia-and-hyperoxia
#15
REVIEW
Laura Terraneo, Michele Samaja
Two antithetic terms, hypoxia and hyperoxia, i.e., insufficient and excess oxygen availability with respect to needs, are thought to trigger opposite responses in cells and tissues. This review aims at summarizing the molecular and cellular mechanisms underlying hypoxia and hyperoxia in brain and cerebral tissue, a context that may prove to be useful for characterizing not only several clinically relevant aspects, but also aspects related to the evolution of oxygen transport and use by the tissues. While the response to acute hypoxia/hyperoxia presumably recruits only a minor portion of the potentially involved cell machinery, focusing into chronic conditions, instead, enables to take into consideration a wider range of potential responses to oxygen-linked stress, spanning from metabolic to genic...
September 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28829495/the-expression-and-mechanism-of-bdnf-and-ngb-in-perihematomal-tissue-in-rats-with-intracerebral-hemorrhage
#16
Y-C Guo, X-K Song, Y-F Xu, J-B Ma, J-J Zhang, P-J Han
OBJECTIVE: To analyze how changes in the levels of brain-derived neurotrophic factor (BDNF) and neuroglobin (NGB) affect learning and memory in rats with intracerebral hemorrhage. MATERIALS AND METHODS: Thirty male Sprague-Dawley rats were randomly divided into the control group, sham operation group and model group with 10 rats each. The rats in the control group were untreated, while those in the sham operation group were treated with sterile saline instead of type VII collagenase injection in the globus pallidus...
August 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28803930/identification-of-neuroglobin-as-a-novel-player-in-anti-bacterial-responses-in-amphioxus
#17
Yu Bai, Shousheng Liu, Xia Wang, Xiaoyuan Du, Guangdong Ji, Shicui Zhang
Theoretical considerations support various functions of neuroglobin (Ngb), but further studies are required for full characterization of these functions. In this study, we identified the presence of a single Ngb gene, BjNgb, in the amphioxus Branchiostoma japonicum. BjNgb was expressed in various tissues including the notochord, gonads (ovary and testis) and gill, and up-regulated significantly in response to the challenge with LPS and LTA, suggesting involvement in immune response of amphioxus against bacterial infection...
December 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28774717/recombinant-neuroglobin-ameliorates-early-brain-injury-after-subarachnoid-hemorrhage-via-inhibiting-the-activation-of-mitochondria-apoptotic-pathway
#18
Fuxiang Chen, Jing Lu, Fan Chen, Zhangya Lin, Yuanxiang Lin, Lianghong Yu, Xingfen Su, Peisen Yao, Bin Cai, Dezhi Kang
Neuroglobin (Ngb) overexpression is considered as an intrinsic neuroprotective response. Therefore, exogenous Ngb increased in brain tissues has become a promising therapeutic strategy for neurological diseases. Previous studies demonstrated that transactivator of transcription (TAT) protein transduction domain was able to mediate synthetic Ngb entrance into neurons, and then protected brain from hypoxia-ischemic injury. However, the role of recombinant Ngb on early brain injury following subarachnoid hemorrhage (SAH) has not been elucidated...
July 31, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28760441/retinal-metabolism-a-comparative-look-at-energetics-in-the-retina
#19
REVIEW
Michael W Country
The retina is part of the central nervous system, and shares the characteristically high metabolism of the brain. The high energy demand of the retina is normally matched with a large supply of metabolites. When supply does not equal demand (e.g. if retinal blood flow is impaired), retinal neurons are at risk of excitotoxic cell death and vision is impaired or lost. Understanding the energetic budget of the retina is therefore crucial for understanding the pathology and treatment of retinal disease. In this minireview I give an overview of the energetics of the retina, with a focus on lessons learnt from comparative physiology...
July 29, 2017: Brain Research
https://www.readbyqxmd.com/read/28721559/anatomical-specificity-of-the-brain-in-the-modulation-of-neuroglobin-and-cytoglobin-genes-after-chronic-bisphenol-a-exposure
#20
Rodrigo Rodrigues da Conceição, Janaina Sena de Souza, Kelen Carneiro de Oliveira, Rui Monteiro de Barros Maciel, Marco Aurélio Romano, Renata Marino Romano, Magnus Régios Dias da Silva, Maria Izabel Chiamolera, Gisele Giannocco
The aim of this study was to investigate the influence of Bisphenol A (BPA) exposure on Neuroglobin (Ngb) and Cytoglobin (Cygb) as well as oxidative stress gene expression in the cerebellum, hippocampus, hypothalamus and cortex. Male Wistar rats were randomly divided into 3 groups: Control and two groups receiving 2 different daily BPA dosages, 5 or 25 mg/kg from postnatal day 50 (PND50) through PND90 and they were euthanized at PND105. In the cortex, we found an increase in Ngb gene expression and also in superoxide dismutase 1 and Catalase (Cat)...
December 2017: Metabolic Brain Disease
keyword
keyword
32538
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"