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Neuroglobin

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https://www.readbyqxmd.com/read/28632164/the-role-of-hemoproteins-hemoglobin-myoglobin-and-neuroglobin-in-endogenous-thiosulfate-production-processes
#1
REVIEW
Anna Bilska-Wilkosz, Małgorzata Iciek, Magdalena Górny, Danuta Kowalczyk-Pachel
Thiosulfate formation and biodegradation processes link aerobic and anaerobic metabolism of cysteine. In these reactions, sulfite formed from thiosulfate is oxidized to sulfate while hydrogen sulfide is transformed into thiosulfate. These processes occurring mostly in mitochondria are described as a canonical hydrogen sulfide oxidation pathway. In this review, we discuss the current state of knowledge on the interactions between hydrogen sulfide and hemoglobin, myoglobin and neuroglobin and postulate that thiosulfate is a metabolically important product of this processes...
June 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28601977/neuroglobin-protects-rats-from-sepsis-associated-encephalopathy-via-a-pi3k-akt-bax-dependent-mechanism
#2
Songyun Deng, Yuhang Ai, Hua Gong, Caixia Chen, Qianyi Peng, Li Huang, Long Wu, Lemeng Zhang, Lina Zhang
Sepsis-associated encephalopathy (SAE) is a common complication of sepsis, and has no generally accepted treatment due to its complicated pathophysiology. Previously, we demonstrated the protective role of neuroglobin (Ngb) in SAE rats, but the exact mechanism has not been determined. To investigate the potential neuroprotective roles and mechanisms of Ngb, Sprague-Dawley rats were used. Overexpression of Ngb via intracerebroventricular injection with Ngb plasmids attenuated brain damage assessed by hematoxylin and eosin (HE) staining and neurological dysfunction assessed by Morris water maze test...
June 10, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28540323/neuroglobin-can-prevent-or-reverse-glaucomatous-progression-in-dba-2j-mice
#3
Hélène Cwerman-Thibault, Christophe Lechauve, Sébastien Augustin, Delphine Roussel, Élodie Reboussin, Ammara Mohammad, Julie Degardin-Chicaud, Manuel Simonutti, Hong Liang, Françoise Brignole-Baudouin, Anne Maron, Thomas Debeir, Marisol Corral-Debrinski
Mitochondrial dysfunction is responsible for hereditary optic neuropathies. We wished to determine whether preserving mitochondrial bioenergetics could prevent optic neuropathy in a reliable model of glaucoma. DBA/2J mice exhibit elevated intraocular pressure, progressive degeneration of their retinal ganglion cells, and optic neuropathy that resembles glaucoma. We established that glaucoma in these mice is directly associated with mitochondrial dysfunction: respiratory chain activity was compromised in optic nerves 5 months before neuronal loss began, and the amounts of some mitochondrial proteins were reduced in retinas of glaucomatous mice...
June 16, 2017: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/28536200/modulation-of-sensory-information-processing-by-a-neuroglobin-in-caenorhabditis-elegans
#4
Shigekazu Oda, Yu Toyoshima, Mario de Bono
Sensory receptor neurons match their dynamic range to ecologically relevant stimulus intensities. How this tuning is achieved is poorly understood in most receptors. The roundworm Caenorhabditis elegans avoids 21% O2 and hypoxia and prefers intermediate O2 concentrations. We show how this O2 preference is sculpted by the antagonistic action of a neuroglobin and an O2-binding soluble guanylate cyclase. These putative molecular O2 sensors confer a sigmoidal O2 response curve in the URX neurons that has highest slope between 15 and 19% O2 and approaches saturation when O2 reaches 21%...
June 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28535644/-effect-of-neuroglobin-on-oxygen-glucose-deprivation-and-reoxygenation-induced-autophagy-in-a-human-neuroblastoma-cell-line
#5
S Y Deng, Y H Ai, H Gong, L Wu, C X Chen, Y M Wang, Z Y Liu, L Huang, Q Y Peng, L N Zhang
Objective: To investigate the effect of neuroglobin on oxygen-glucose deprivation and reoxygenation (OGD/R) induced autophagy in a human neuroblastoma cell line (SH-SY5Y). Methods: SH-SY5Y cells were transfected with plasmids (or vector) to establish a stable cell line of NGB overexpression (OE). After treated with OGD/R, cells were collected for the analyses of mRNA (Atg5, Atg7, BECN1 and FUNDC1) and protein levels of LC3. Furthermore, mitochondrial and cytosolic fractions were isolated for protein levels of PINK1 and Parkin...
May 23, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28500341/determinants-of-neuroglobin-plasticity-highlighted-by-joint-coarse-grained-simulations-and-high-pressure-crystallography
#6
Nathalie Colloc'h, Sophie Sacquin-Mora, Giovanna Avella, Anne-Claire Dhaussy, Thierry Prangé, Beatrice Vallone, Eric Girard
Investigating the effect of pressure sheds light on the dynamics and plasticity of proteins, intrinsically correlated to functional efficiency. Here we detail the structural response to pressure of neuroglobin (Ngb), a hexacoordinate globin likely to be involved in neuroprotection. In murine Ngb, reversible coordination is achieved by repositioning the heme more deeply into a large internal cavity, the "heme sliding mechanism". Combining high pressure crystallography and coarse-grain simulations on wild type Ngb as well as two mutants, one (V101F) with unaffected and another (F106W) with decreased affinity for CO, we show that Ngb hinges around a rigid mechanical nucleus of five hydrophobic residues (V68, I72, V109, L113, Y137) during its conformational transition induced by gaseous ligand, that the intrinsic flexibility of the F-G loop appears essential to drive the heme sliding mechanism, and that residue Val 101 may act as a sensor of the interaction disruption between the heme and the distal histidine...
May 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28495447/characterization-of-gene-expression-associated-with-the-adaptation-of-the-nematode-c-elegans-to-hypoxia-and-reoxygenation-stress-reveals-an-unexpected-function-of-the-neuroglobin-glb-5-in-innate-immunity
#7
Binyamin Zuckerman, Zohar Abergel, Veronica Zelmanovich, Leonor Romero, Rachel Abergel, Leonid Livshits, Yoav Smith, Einav Gross
Oxygen (O2) is a double-edged sword to cells, for while it is vital for energy production in all aerobic animals and insufficient O2 (hypoxia) can lead to cell death, the reoxygenation of hypoxic tissues may trigger the generation of reactive oxygen species (ROS) that can destroy any biological molecule. Indeed, both hypoxia and hypoxia-reoxygenation (H/R) stress are harmful, and may play a critical role in the pathophysiology of many human diseases, such as myocardial ischemia and stroke. Therefore, understanding how animals adapt to hypoxia and H/R stress is critical for developing better treatments for these diseases...
May 8, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28466269/pdgf-bb-preserves-mitochondrial-morphology-attenuates-ros-production-and-upregulates-neuroglobin-in-an-astrocytic-model-under-rotenone-insult
#8
Ricardo Cabezas, Nelson E Vega-Vela, Juliana González-Sanmiguel, Janneth González, Paula Esquinas, Valentina Echeverria, George E Barreto
Platelet-derived growth factor, subtype BB (PDGF-BB) is a mitogenic growth factor produced in different cell types such as platelets, fibroblasts, neurons, and astrocytes. Previous reports have shown that different PDGF isoforms exert a neuroprotective effect in neurons and astrocytes against multiple degenerative insults. Previously, we showed that pretreatment with PDGF-BB for 24 h increased cell viability, preserved nuclear morphology and mitochondrial membrane potential following stimulation with rotenone, and reduced free radical production nearly to control conditions...
May 2, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28428250/functional-roles-of-globin-proteins-in-hypoxia-tolerant-ectothermic-vertebrates
#9
Angela Fago
Globins are heme-containing proteins ubiquitously expressed in vertebrates, where they serve a broad range of biological functions, directly or indirectly related to the tight control of oxygen levels and its toxic products in vivo. Perhaps the most investigated of all proteins, hemoglobin and myoglobin are primarily involved in oxygen transport and storage, but also in facilitating arterial vasodilation, suppressing mitochondrial respiration and preventing tissue oxidative damage via accessory redox enzymatic activities during hypoxia...
April 20, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28410531/tumor-grade-related-expression-of-neuroglobin-is-negatively-regulated-by-ppar%C3%AE-and-confers-antioxidant-activity-in-glioma-progression
#10
Jing Hu, Xiyue Cao, Dejiang Pang, Qihui Luo, Yuanfeng Zou, Bin Feng, Lixia Li, Zhengli Chen, Chao Huang
Neuroglobin (NGB), distributed mainly in central and peripheral nervous systems, is a nerve globin with neuroprotective effects against oxidative stress resulting from hypoxia and ischemia. Recent studies have indicated that the expression of NGB is related to neurodegenerative disorders and cancers, but the molecular mechanisms for its transcriptional regulation and protection are not well defined. Here, we report that the expression of NGB in glioma is grade related and is negatively regulated by PPARγ. Specific PPARγ agonist reduces the expression of NGB, while its inhibitor enhances the expression...
August 2017: Redox Biology
https://www.readbyqxmd.com/read/28378164/computational-evidence-support-the-hypothesis-of-neuroglobin-also-acting-as-an-electron-transfer-species
#11
Licia Paltrinieri, Giulia Di Rocco, Gianantonio Battistuzzi, Marco Borsari, Marco Sola, Antonio Ranieri, Laura Zanetti-Polzi, Isabella Daidone, Carlo Augusto Bortolotti
Neuroglobin (Ngb) is a recently identified hexa-coordinated globin, expressed in the nervous system of humans. Its physiological role is still debated: one hypothesis is that Ngb serves as an electron transfer (ET) species, possibly by reducing cytochrome c and preventing it to initiate the apoptotic cascade. Here, we use the perturbed matrix method (PMM), a mixed quantum mechanics/molecular dynamics approach, to investigate the redox thermodynamics of two neuroglobins, namely the human Ngb and GLB-6 from invertebrate Caenorhabditis elegans...
April 4, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28359933/recombinant-human-erythropoietin-offers-neuroprotection-through-inducing-endogenous-erythropoietin-receptor-and-neuroglobin-in-a-neonatal-rat-model-of-periventricular-white-matter-damage
#12
Lihua Zhu, Li Huang, Quan Wen, Ting Wang, Lixing Qiao, Li Jiang
Recombinant human erythropoietin (rh-EPO) has been reported to have protective effects against brain injury. The purpose of this study was to evaluate the levels of erythropoietin receptor (EPOR) and neuroglobin (Ngb) in a neonatal rat model of periventricular white matter damage (PWMD), and to identify the relationship between the two proteins. On postnatal day 3 (P3), rats underwent permanent ligation of the right common carotid artery followed by 6% O2 for 4h (HI) or sham operation and normoxic exposure (sham)...
March 27, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28332151/blockade-of-neuroglobin-reduces-protection-of-conditioned-medium-from-human-mesenchymal-stem-cells-in-human-astrocyte-model-t98g-under-a-scratch-assay
#13
Eliana Baez-Jurado, Gina Guio Vega, Gjumrakch Aliev, Vadim V Tarasov, Paula Esquinas, Valentina Echeverria, George E Barreto
Previous studies have indicated that paracrine factors (conditioned medium) increase wound closure and reduce reactive oxygen species in a traumatic brain injury in vitro model. Although the beneficial effects of conditioned medium from human adipose tissue-derived mesenchymal stem cells (hMSCA-CM) have been previously suggested for various neurological diseases, their actions on astrocytic cells are not well understood. In this study, we have explored the effect of hMSCA-CM on human astrocyte model (T98G cells) subjected to scratch assay...
March 22, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28320188/clinical-significance-of-changes-in-serum-neuroglobin-and-hif-1%C3%AE-concentrations-during-the-early-phase-of-acute-ischemic-stroke
#14
Lixia Xue, Hao Chen, Kaili Lu, Jiankang Huang, Hao Duan, Yuwu Zhao
BACKGROUND: Neuroglobin (NGB) has been described as a neuroprotective agent in cerebral ischemia, hypoxia inducible factor (HIF) has shown an important role in modulating hypoxic and ischemic injury, and therefore they have the potential to impact outcomes after acute ischemic stroke (AIS). Thus, we investigated early changes in the concentrations of serum NGB and HIF-1α after AIS and evaluated the relations of both NGB and HIF-1α to stroke severity and prognosis. METHODS: We prospectively measured the serum concentrations of NGB and HIF-1α in 40 patients with AIS at 24, 48, 72, and 96h after stroke...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28316021/hemin-protects-against-oxygen-glucose-deprivation-induced-apoptosis-activation-via-neuroglobin-in-sh-sy5y-cells
#15
Yun-Jia Wang, Qian-Yi Peng, Song-Yun Deng, Cai-Xia Chen, Long Wu, Li Huang, Li-Na Zhang
This study aimed to investigate the mechanism underlying the neuroprotective effect of hemin in oxygen-glucose deprivation (OGD)-treated neurons. OGD-treated SH-SY5Y cells (human neuroblastoma cells) were used in the study. The cellular viability of SH-SY5Y cells was assessed by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, and the cell apoptosis rate was determined by flow cytometry analysis with Annexin V-fluorescein isothiocyanate and propidium iodide staining with or without hemin pretreatment...
March 18, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28293020/untangling-the-relationship-between-diet-and-visceral-fat-mass-through-blood-metabolomics-and-gut-microbiome-profiling
#16
T Pallister, M A Jackson, T C Martin, C A Glastonbury, A Jennings, M Beaumont, R P Mohney, K S Small, A MacGregor, C J Steves, A Cassidy, T D Spector, C Menni, A M Valdes
BACKGROUND/OBJECTIVES: Higher visceral fat mass (VFM) is associated with an increased risk for developing cardio-metabolic diseases. The mechanisms by which an unhealthy diet pattern may influence VF development has yet to be examined through cutting-edge multi-omic methods. Therefore, our objective was to examine the dietary influences on VFM and identify gut microbiome and metabolite profiles that link food intakes to VFM. SUBJECTS/METHODS: In 2218 twins with VFM, food intake and metabolomics data available we identified food intakes most strongly associated with VFM in 50% of the sample, then constructed and tested the 'VFM diet score' in the remainder of the sample...
March 15, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28246171/a-distal-ligand-mutes-the-interaction-of-hydrogen-sulfide-with-human-neuroglobin
#17
Markus Ruetz, Jacques Kumutima, Brianne E Lewis, Milos R Filipovic, Nicolai Lehnert, Timothy L Stemmler, Ruma Banerjee
Hydrogen sulfide is a critical signaling molecule, but high concentrations cause cellular toxicity. A four-enzyme pathway in the mitochondrion detoxifies H2S by converting it to thiosulfate and sulfate. Recent studies have shown that globins like hemoglobin and myoglobin can also oxidize H2S to thiosulfate and hydropolysulfides. Neuroglobin, a globin enriched in the brain, was reported to bind H2S tightly and was postulated to play a role in modulating neuronal sensitivity to H2S in conditions such as stroke...
April 21, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28193153/molecular-evolution-of-globin-genes-in-gymnotiform-electric-fishes-relation-to-hypoxia-tolerance
#18
Ran Tian, Mauricio Losilla, Ying Lu, Guang Yang, Harold Zakon
BACKGROUND: Nocturnally active gymnotiform weakly electric fish generate electric signals for communication and navigation, which can be energetically taxing. These fish mainly inhabit the Amazon basin, where some species prefer well-oxygenated waters and others live in oxygen-poor, stagnant habitats. The latter species show morphological, physiological, and behavioral adaptations for hypoxia-tolerance. However, there have been no studies of hypoxia tolerance on the molecular level. Globins are classic respiratory proteins...
February 13, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/28103511/neuroglobin-functions-as-a-prognostic-marker-and-promotes-the-tumor-growth-of-glioma-via-suppressing-apoptosis
#19
Bei Zhang, Mingze Chang, Juanhong Wang, Yong Liu
Neuroglobin (Ngb) has been reported to be upregulated by hypoxia and plays an anti-apoptotic function. Previous studies have reported that Ngb is expressed in human glioblastoma cells and up-regulated in hypoxic microregions of glioblastoma tumor xenografts. While, the clinical significance of Ngb and its function in human glioma keep unknown. Ngb expression was analyzed in 86 glioma tissues and 20 normal brain tissues. Results showed that Ngb was significantly overexpressed in glioma tissues compared to normal brain tissues...
April 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28056323/-the-role-of-neuroglobin-in-oxygen-glucose-deprivation-and-reoxygenation-induced-mitochondrial-depolarization-and-reactive-oxygen-species-production-in-sh-sy5y-cells
#20
S Y Deng, Y H Ai, L N Zhang, L Wu, C X Chen, Y M Wang, Z Y Liu, L Huang, Q Y Peng
Objective: To investigate the role of neuroglobin (NGB) in oxygen-glucose deprivation and reoxygenation (OGD/R) induced mitochondrial depolarization and reactive oxygen species (ROS)production in a human neuroblastoma cell line (SH-SY5Y). Methods: SH-SY5Y cells were transfected with lentivirus to establish a stable cell line of NGB knockdown (KD). After treated with OGD/R, cells were collected at different time points to analyze NGB mRNA and protein levels. Furthermore, cells were stained with JC-1 and DCFH-DA to evaluate mitochondrial depolarization and ROS production by inverted fluorescence microscope...
January 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
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