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https://www.readbyqxmd.com/read/29668916/extraintestinal-manifestations-in-vedolizumab-and-anti-tnf-treated-patients-with-inflammatory-bowel-disease
#1
Marla C Dubinsky, Raymond K Cross, William J Sandborn, Millie Long, Xue Song, Nianwen Shi, Yao Ding, Samantha Eichner, Brandee Pappalardo, Arijit Ganguli, Anthony Wang
Background: Extra-intestinal manifestations (EIMs) can impact morbidity in patients with inflammatory bowel diseases (IBD; Crohn's disease [CD] and ulcerative colitis [UC]). This study compared incidence rates of EIMs in patients with moderate to severe IBD receiving gut-selective vedolizumab (VDZ) vs those receiving systemic anti-tumor necrosis factor (anti-TNF) therapies. Methods: Adult IBD patients receiving VDZ or anti-TNFs were identified from the MarketScan claims database from September 28, 2012, through September 30, 2016...
April 13, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29666122/iontophoretic-delivery-of-dexamethasone-phosphate-for-non-infectious-non-necrotising-anterior-scleritis-dose-finding-clinical-trial
#2
Erin C O'Neil, Jiayan Huang, Eric B Suhler, James P Dunn, Victor L Perez, David C Gritz, Kathy McWilliams, Ellen Peskin, Gui-Shuang Ying, Vatinee Y Bunya, Maureen G Maguire, John H Kempen
Currently available treatment options for non-infectious scleritis, including non-steroidal anti-inflammatory drugs, systemic corticosteroids and immunosuppressive therapies, have both efficacy and side effect limitations. Iontophoretic delivery of corticosteroids has been demonstrated to be effective for anterior uveitis and represents a potential new approach to scleritis therapy. We hypothesised that iontophoretic delivery would provide effective and precise medication delivery to the sclera, while limiting systemic exposure and side effects...
April 17, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29664747/scleral-patch-graft-with-a-suture-reinforcement-technique-in-surgical-management-of-necrotizing-scleritis-with-ectasia
#3
Joanne C Wen, Jocelyn Lam, Michael R Banitt
PURPOSE: To describe a technique for reducing and reinforcing scleral thinning in cases of necrotizing scleritis with ectasia. METHODS: Descriptive report of a surgical technique in 2 surgical cases with a video. RESULTS: Successful repair and reduction in uveal prolapse from scleral thinning in 2 cases of necrotizing scleritis with ectasia with a suturing technique using overlapping (weave) compressive suturing over a scleral patch. CONCLUSIONS: In cases of necrotizing scleritis with ectasia in which there is perforation or prolapsing uvea, this technique should be considered...
April 16, 2018: Cornea
https://www.readbyqxmd.com/read/29656910/glycemic-control-is-an-important-modifiable-risk-factor-for-uveitis-in-patients-with-diabetes-a-retrospective-cohort-study-establishing-clinical-risk-and-ophthalmic-disease-burden
#4
Abdus Samad Ansari, Simon de Lusignan, William Hinton, Neil Munro, Simon Taylor, Andrew McGovern
AIM: To characterize the risk uveitis, scleritis or episcleritis in relation to diabetes, glycaemic control, and co-existence of retinopathy. METHODS: Using the Royal College of General Practitioners Research and Surveillance Centre database, we established the prevalence of acute uveitis and scleritis or episcleritis over a six-year period among populations without(n = 889,856) and with diabetes(n = 48,584). We evaluated the impact of glycaemic control on disease risk...
March 23, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29643776/patch-grafting-using-an-ologen-collagen-matrix-to-manage-tubal-exposure-in-glaucoma-tube-shunt-surgery
#5
Masaki Tanito, Ichiya Sano, Yoshifumi Ikeda, Etsuko Fujihara
Purpose: To report the results using an ologen Collagen Matrix as a patch graft in eyes with tubal exposure after tube shunt surgery. Case Reports: Case 1 was an 82-year-old man with tubal exposure in his right eye 26 months after receiving a Baerveldt glaucoma implant. The tube was covered by surrounding conjunctival tissue combined with subconjunctival placement of an ologen Collagen Matrix as a patch graft. Two years after implantation, the tube was not exposed...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29580956/the-use-of-miltefosine-in-the-management-of-refractory-acanthamoeba-keratitis
#6
Shokufeh Tavassoli, Miranda Buckle, Derek Tole, Peter Chiodini, Kieren Darcy
Acanthamoeba keratitis (AK) is a sight threatening infection most commonly affecting contact lens wearers. The authors report a case of intractable A.polyphaga and A.castellanii, with extensive intraocular spread, managed using oral miltefosine. A 59-year old male contact lens wearer was referred to the tertiary corneal service at Bristol Eye Hospital. Vision was hand movements on the left and 6/6 on the right. Clinical examination was consistent with left AK (confirmed by corneal scrape). Management included biguanide (polyhexamethylene biguanide (PHMB) 0...
March 23, 2018: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/29564803/the-impact-of-ocular-manifestations-of-rheumatoid-arthritis-on-the-health-related-quality-of-life-and-the-functional-ability-of-black-africans
#7
Richard Oluyinka Akintayo, Olufemi Oladipo Adelowo, Ochuko Egajifo, Rukayyah Abisoye Popoola, Gbenga Joshua Odunlami, Airenakho Emorinken, Babatunde Hakeem Olaosebikan
Objectives To determine the patterns, predictors and overall impact of ocular manifestations of rheumatoid arthritis (RA) on the health-related quality of life and disability index. METHODS: A total of 50 Nigerian patients with RA were studied. Full ocular evaluation was done to determine the presence of each defined ocular manifestation of RA. All patients completed the Medical Outcome Study 36-Item Short Form Health Survey (SF-36) and the Health Assessment Questionnaire-Disability Index (HAQ-DI) questionnaires...
March 21, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29511745/combination-nivolumab-and-cabiralizumab-associated-acute-bilateral-anterior-and-posterior-scleritis-and-anterior-uveitis
#8
John A Gonzales, Jessica Shantha, Nisha R Acharya
Purpose: To report on a case of uveitis and scleritis resulting as an immune-mediated side effect of cancer immunotherapy with nivolumab and cabiralizumab. Observations: Bilateral anterior nongranulomatous anterior uveitis and bilateral diffuse anterior and posterior scleritis occurred following the use of combination cancer immunotherapy. The uveitis and scleritis resolved following temporary discontinuation of nivolumab and cabiralizumab as well as systemic prednisone...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29503941/case-series-two-cases-of-eyeball-tattoos-with-short-term-complications
#9
Gonzalo Duarte, Rashel Cheja, Diana Pachón, Carolina Ramírez, Lourdes Arellanes
Purpose: To report two cases of eyeball tattoos with short-term post procedural complications. Observations: Case 1 is a 26-year-old Mexican man that developed orbital cellulitis and posterior scleritis 2 h after an eyeball tattoo. Patient responded satisfactorily to systemic antibiotic and corticosteroid treatment. Case 2 is a 17-year-old Mexican man that developed two sub-episcleral nodules in the ink injection sites immediately after the procedure. Conclusions and importance: Eyeball tattoos are performed by non-ophthalmic trained personnel...
April 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29503939/anterior-infectious-necrotizing-scleritis-secondary-to-pseudomonas-aeruginosa-infection-following-intravitreal-ranibizumab-injection
#10
Razek Georges Coussa, Susan M Wakil, Hady Saheb, David E Lederer, Karin M Oliver, Devinder P Cheema
Purpose: To report the occurrence and management of severe infectious scleritis in a 75 year-old woman following intravitreal ranibizumab injection. Observations: A 75 year-old monocular woman receiving monthly intravitreal ranibizumab injection for wet age related macular degeneration in the left eye presented with severe dull pain, decreased vision, and scleral melt with discharge 2 weeks after her last injection. The dilated fundus exam was devoid of vitritis...
April 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29496270/-scleritis-and-systemic-diseases-what-should-know-the-internist
#11
P Bielefeld, D Saadoun, E Héron, S Abad, H Devilliers, C Deschasse, S Trad, D Sène, G Kaplanski, P Sève
Scleritis is an inflammatory disease of the sclera; outer tunic of the eye on which the oculomotor muscles are inserted. It can be associated with a systemic disease up to one time out of 3. These associated diseases are mainly rheumatoid arthritis, vasculitis, including granulomatosis with polyangiitis in the first line and spondyloarthropathies. Before mentioning such an etiology, it is necessary to eliminate an infectious cause, mainly herpetic, which is regularly underestimated. The classification of scleritis is clinical...
February 26, 2018: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29480270/successful-management-of-bee-sting-induced-aspergillus-fumigatus-endophthalmitis-and-scleritis
#12
Mohit Dogra, Subina Narang, Sunandan Sood, Panchmi Gupta
Ocular bee stings are known to cause corneal melts, corneal infiltrates, cataracts, and secondary glaucoma. Our patient presented with scleritis, corneal infiltrates, and endophthalmitis after a ocular bee sting. Topical treatment led to resolution of anterior segment inflammation, but the scleritis and vitreous inflammation worsened. Vitrectomy with intravitreal antibiotics was done and scrapings from the scleral abscess showed growth of Aspergillus fumigatus on culture. Repeat vitrectomy with silicone oil was needed for retinal detachment...
March 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29474126/association-of-low-vitamin-d-levels-with-noninfectious-uveitis-and-scleritis
#13
Stephanie M Llop, Samaneh Davoudi, Lynn K Stanwyck, Shaleen Sathe, Lisa Tom, Tina Ahmadi, Lindsay Grotting, George N Papaliodis, Lucia Sobrin
PURPOSE: To determine whether an association between Vitamin D and noninfectious ocular inflammation exists. METHODS: Retrospective case-control study with 765 patients (333 uveitis cases, 103 scleritis cases, 329 controls). Logistic regression models examined the relationship between hypovitaminosis D and ocular inflammation. RESULTS: The odds of having uveitis were 1.92 times higher for patients with hypovitaminosis D compared to patients with normal Vitamin D levels in the multivariate analysis [odds ratio (OR) = 1...
February 23, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29452446/sj%C3%A3-gren-s-disease-associated-with-severe-retinal-vasculitis-and-or-necrotizing-scleritis-two-cases
#14
Sophie Lopez Baumann, Amelie Borgeat Kaeser, Flore Valerio, Francois Spertini, Yan Guex-Crosier
No abstract text is available yet for this article.
February 16, 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29449499/clinical-correlates-outcomes-and-predictors-of-inflammatory-ocular-disease-associated-with-rheumatoid-arthritis-in-the-biologic-era
#15
Cristian Caimmi, Cynthia S Crowson, Wendy M Smith, Eric L Matteson, Ashima Makol
OBJECTIVE: Inflammatory ocular disease (IOD) is a rare but severe extraarticular manifestation of rheumatoid arthritis (ExRA) with high mortality. The aim of our study was to examine clinical characteristics of IOD in rheumatoid arthritis (RA) and their effect on disease severity and outcomes in recent years. METHODS: A retrospective cohort of RA patients with IOD evaluated between 1996 and 2013 was assembled and compared to RA comparators without IOD and matched for age, sex, and disease duration...
February 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29441167/is-this-a-worrisome-red-eye-episcleritis-in-the-primary-care-setting
#16
Amr Salama, Arwa Elsheikh, Richard Alweis
Episcleritis is the inflammation of the thin, loose, highly vascular connective tissue layer that lies between the conjunctiva and sclera. Incidence is less than 1/1000. It is more common in women and those between 40 and 50 years of age. Most cases are idiopathic. It is classified into simple and nodular. Most attacks resolve within 1-3 months. The nodular type tends to be more recurrent and painful. It presents with acute onset of redness, lacrimation, and photophobia. The diagnosis of is essentially clinical, and eye pain or tenderness should raise the concern for scleritis...
2018: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29433463/scedosporium-apiospermum-infectious-scleritis-following-posterior-subtenon-triamcinolone-acetonide-injection-a-case-report-and-literature-review
#17
REVIEW
Daisuke Todokoro, Junki Hoshino, Ayaka Yo, Koichi Makimura, Junko Hirato, Hideo Akiyama
BACKGROUND: Ubiquitous fungi of the Scedosporium apiospermum species complex (SASC) cause various opportunistic infections. Posterior subtenon triamcinolone acetonide (STTA) injection is a standard therapy for intraocular inflammation and macular edema. We report a case of Scedosporium apiospermum infectious scleritis after a posterior STTA injection. CASE PRESENTATION: A 75-year-old man received a posterior STTA injection to treat macular edema in his left eye...
February 13, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29382031/anterior-scleritis-following-intravitreal-injections-in-a-patient-with-rheumatoid-arthritis-a-case-report
#18
So Jung Ryu, Min Ho Kang, Mincheol Seong, Heeyoon Cho, Yong Un Shin
RATIONALE: Surgically induced scleritis is a rare complication following ophthalmologic surgery such as cataract surgery, pterygium excision, strabismus surgery, and retinal detachment repair. Rheumatoid arthritis (RA) is the connective tissue disease most commonly associated with scleritis. PATIENT CONCERNS: A 70-year-old woman visited our clinic with complaint of visual disturbance, ocular pain, and conjunctival injection in her right eye of 1 month's duration...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29370565/clinical-profile-of-scleritis-in-children
#19
Parthopratim Dutta Majumder, Sowkath Ali, Amala George, Sudha Ganesh, Jyotirmay Biswas
PURPOSE: To describe the clinical pattern of scleritis in patients ≤16 years of age at a tertiary care eye hospital in India. METHODS: The medical records of 24 eyes of 20 children with scleritis were included in this retrospective study. Collected data included age, subsets of uveitis, best corrected visual acuities (BCVA), detailed laboratory investigations and treatment. RESULTS: Mean age at presentation was 12.2 ± 2.5 years. Scleritis was unilateral in 80% patients and an equal gender distribution was observed...
January 25, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29369534/autoimmunity-in-uveitis
#20
Josianne C Ten Berge, Marco W J Schreurs, Paul L A van Daele, Aniki Rothova
PURPOSE: Recent insights into the pathogenesis of immune-mediated diseases proposed a new classification, which includes autoimmune and auto-inflammatory diseases. The prevalence of specific autoimmune and auto-inflammatory diseases in uveitis and/or scleritis is not yet known. In this study, we examine the presence of systemic immune-mediated diseases in patients with uveitis and/or scleritis and put a special emphasis on autoimmune disorders by reporting on their clinical manifestations and visual prognosis...
January 25, 2018: Acta Ophthalmologica
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