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https://www.readbyqxmd.com/read/29926173/relationship-of-ocular-presentation-in-granulomatosis-with-polyangiitis-to-autoantibodies-and-disease-activity
#1
T A Gheita, E M Abd El Latif
OBJECTIVE: The aim of this study was to assess disease characteristics, autoantibodies, and disease activity in granulomatosis with polyangiitis (GPA) patients with ocular manifestations. METHODS: The cohort included 46 GPA patients visiting the ophthalmology clinic. Ocular manifestations were recorded, clinical and slit lamp examinations were performed. The Birmingham Vasculitis Activity Score (BVAS) was recorded. Laboratory investigations and the antineutrophil cytoplasmic antibody (ANCA) assay were performed...
June 20, 2018: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/29925554/cogan-s-syndrome-with-pyoderma-gangrenosum-management-of-two-uncommon-disorders-with-aggressive-presentation-in-a-patient
#2
Ezolene Pei-Chin Chua, Richard B Mallett, Sandeep Dahiya
Pyoderma gangrenosum (PG) coexisting with Cogan's syndrome (CS) is uncommon, although cutaneous manifestations are known to develop in CS. A middle-aged white female patient had chronic relapsing PG requiring ciclosporin and prednisolone. Despite receiving optimal doses of ciclosporin and prednisolone, she developed acute vestibulo-auditory symptoms as a result of CS. Ciclosporin was switched to methotrexate and prednisolone was increased. However, she continued to develop acute scleritis, requiring methylprednisolone pulses, and still had further flares of PG...
June 19, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29904831/pain-in-optic-neuropathies
#3
Stefania Bianchi Marzoli, Alessandra Criscuoli
Pain occurs with optic neuropathies associated with inflammatory central nervous system diseases (MS and NMO), idiopathic intracranial hypertension and spontaneous hypotension, giant cell arteritis, immunomediated systemic diseases, compressive lesions, or infective disorders. Pain can precede the onset of visual loss in acute optic neuritis, it can be irradiated to the orbital region in giant cell arteritis and parasellar compressive optic neuropathies, or it may be located to the back of the eye with posterior scleritis...
June 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29846785/clinical-features-of-different-orbital-manifestations-of-granulomatosis-with-polyangiitis
#4
D S Ismailova, J V Abramova, P I Novikov, Y O Grusha
PURPOSE: The aim of this study was to distinguish different forms of orbital involvement in granulomatosis with polyangiitis (GPA) and to compare their clinical course and outcomes. METHODS: Two hundred twenty-six consecutive patients with GPA were retrospectively studied. All patients fulfilled the classification criteria of American College of Rheumatology; diagnosis of localized GPA was established according to Chapel Hill Consensus. Of those, 74 patients with orbital disease were enrolled into further investigation of different forms of orbital disease...
May 30, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29843653/a-case-of-scleritis-associated-rheumatoid-arthritis-accompanying-an-intraocular-elevated-lesion
#5
Takatoshi Kobayashi, Nanae Takai, Rei Tada, Hiromi Shoda, Teruyo Kida, Tsunehiko Ikeda, Takurou Ozaki, Shigeki Makino
BACKGROUND: Scleritis and/or uveitis sometimes accompanies patients who suffer from rheumatoid arthritis. However, few studies have reported scleritis and/or uveitis accompanying a fundus elevated lesion, such as an intraocular tumor. In this study, we report a case of rheumatoid uveitis associated with an intraocular elevated lesion. CASE PRESENTATION: A 66-year-old female visited another eye clinic and was diagnosed as bilateral anterior uveitis, and was prescribed steroid eye drops for treatment...
May 30, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29796754/clinical-characteristics-and-ocular-complications-of-patients-with-scleritis-in-japanese
#6
Rie Tanaka, Toshikatsu Kaburaki, Kazuyoshi Ohtomo, Mitsuko Takamoto, Keiko Komae, Jiro Numaga, Yujiro Fujino, Makoto Aihara
PURPOSE: To investigate the clinical characteristics of Japanese patients with scleritis STUDY DESIGN: Retrospective study METHODS: The clinical records of 123 patients with scleritis, who presented to the University of Tokyo Hospital between January, 2004 and December, 2015, were retrospectively reviewed. RESULTS: The cohort comprised 55 men and 68 women (mean age, 57.8±16.4 years), of which 76 showed anterior diffuse scleritis, 17 showed anterior nodular scleritis, 10 showed anterior necrotizing scleritis, and 20 showed posterior scleritis...
May 23, 2018: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29794824/limbal-stem-cell-deficiency-secondary-to-diffuse-non-necrotizing-anterior-scleritis-a-clinicopathological-report
#7
Lin Wei Khoo, Michelle Attzs, Sathish Srinivasan, Fiona Roberts
PURPOSE: To report a case of limbal stem cell deficiency (LSCD) secondary to diffuse non-necrotizing anterior scleritis (DNNAS). METHOD: Interventional case report with clinicopathologic correlation. A 69-year-old white woman with known Crohn disease presented with DNNAS. The acute inflammatory phase was treated with topical and systemic steroids. After DNNAS, she developed secondary LSCD with loss of limbal palisades of Vogt and conjunctivalization of the corneal surface and corneal haze...
May 23, 2018: Cornea
https://www.readbyqxmd.com/read/29781927/a-case-of-corneal-neovascularization-misdiagnosed-as-total-limbal-stem-cell-deficiency
#8
Qihua Le, C Michael Samson, Sophie X Deng
PURPOSE: To report a case of corneal neovascularization misdiagnosed as total limbal stem cell deficiency (LSCD). METHODS: This is a case report of a 61-year-old woman who has a history of bilateral idiopathic scleritis, keratitis, and uveitis for more than 20 years. She was diagnosed with total LSCD in her left eye based on clinical presentation alone and was confirmed as a candidate for limbal transplantation at several major tertiary eye care centers in the United States...
May 16, 2018: Cornea
https://www.readbyqxmd.com/read/29780955/management-of-inadvertent-needle-penetration-resulting-in-subretinal-triamcinolone-acetonide-and-retinal-detachment
#9
Kimberly D Tran, Ashley M Crane, Harry W Flynn
Purpose: To report management of inadvertent needle penetration during subtenons triamcinolone acetonide administration resulting in retinal detachment. Observations: A 71-year-old female with history of diabetes, hypothyroidism, and mild myopia underwent subtenons triamcinolone acetonide (TA) injection in the right eye for nodular scleritis. There was unexpected patient movement concurrent with the injection resulting in needle penetration, subretinal and intravitreal injection of TA, superotemporal retinal break, and macula-involving retinal detachment...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29780912/orbital-implant-exposure-after-acanthamoeba-panophthalmitis
#10
Meredith S Baker, Amanda C Maltry, Nasreen A Syed, Richard C Allen
Purpose: Acanthamoeba is a protozoa that can lead to severe ocular disease and sequelae. Although intraocular Acanthamoeba infection is rare, the following case demonstrates an unusual presentation of recurrent Acanthamoeba infection in a 30 year old contact lens wearing male. Observations: After presenting with recurrent Acanthamoeba keratitis and undergoing various treatments, the patient developed nodular scleritis, which evolved into panophthalmitis, and ultimately, required enucleation...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29780901/nocardial-scleritis-a-case-report-and-a-suggested-algorithm-for-disease-management-based-on-a-literature-review
#11
Laura Pires da Cunha, Verena Juncal, Cecília Godoy Carvalhaes, Sylvia Cardoso Leão, Erica Chimara, Denise Freitas
Purpose: To report a case of nocardial scleritis and to propose a logical treatment algorithm based on a literature review. Observations: It is important to suspect a nocardial infection when evaluating anterior unilateral scleritis accompanied by multiple purulent or necrotic abscesses, especially in male patients with a history of chronic ocular pain and redness, trauma inflicted by organic materials, or recent ophthalmic surgery. A microbiological investigation is essential...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29764818/necrotising-scleritis-keratitis-and-uveitis-in-primary-antiphospholipid-syndrome
#12
Brijesh Takkar, Sudarshan Khokhar, Uma Kumar, Pradeep Venkatesh
Ocular manifestations of antiphospholipid syndrome typically include thromboembolic and neuro-ophthalmic complications. In this report we present a case of inflammation of the ocular coats in a patient diagnosed with antiphospholipid syndrome 16 years prior. We discuss management of the case and the possible aetiology of the rare association.
May 14, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29738013/atypical-posterior-scleritis-mimicking-choroidal-melanoma
#13
Heba M Alsharif, Saad A Al-Dahmash
We report a case of atypical posterior scleritis mimicking amelanotic choroidal melanoma. A 30-year-old healthy Filipino man, with a history of painless subacute loss of vision in his left eye over 5 months, was referred to our institute for further workup and management. On examination, visual acuity of the left eye was 20/200. Anterior segment examination yielded unremarkable results, with injected conjunctiva and quiet episcleral blood vessels, while fundus examination revealed non-pigmented nasal choroidal mass, with significant subretinal fluid resembling amelanotic choroidal melanoma...
May 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29719652/simultaneous-unilateral-presentation-of-three-different-ocular-manifestations-of-granulomatosis-with-polyangiitis
#14
Ali Salehi, Farzan Kianersi, Heshmatollah Ghanbari, Zahra Dastborhan, Ebrahim Gerami, Elnaz Pirmoazzen
Purpose: To report the simultaneous presentation of three ocular manifestations of granulomatosis with polyangiitis in one eye. Case Report: A 42-year-old man with a confirmed diagnosis of granulomatosis with polyangiitis was referred to the emergency room with sudden blurred vision. Eye examination showed hyperemic conjunctiva due to necrotizing scleritis in the superior nasal quadrant of the left eye, a mass in the left superior lid, as well as central retinal artery occlusion in the same eye...
April 2018: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/29719651/combined-tenonplasty-and-scleral-graft-for-refractory-pseudomonas-scleritis-following-pterygium-removal-with-mitomycin-c-application
#15
Heidar Siatiri, Nima Mirzaee-Rad, Shruti Aggarwal, Ahmad Kheirkhah
Purpose: To report a surgical approach combining scleral patch graft and tenonplasty for successful management of refractory Pseudomonas scleritis following pterygium removal with mitomycin C application. Case Report: A 75-year-old diabetic woman with a history of prior pterygium excision and mitomycin C application developed infectious necrotizing scleritis caused by Pseudomonas aeruginosa . Owing to progression of scleritis despite medical management, the patient underwent surgery...
April 2018: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/29718374/epidemiology-of-hypocomplementaemic-urticarial-vasculitis-anti-c1q-vasculitis
#16
Christopher Sjöwall, Thomas Mandl, Lillemor Skattum, Martin Olsson, Aladdin J Mohammad
Objectives: The aim was to describe the clinical characteristics and epidemiology of hypocomplementaemic urticarial vasculitis (HUV; anti-C1q vasculitis) in two geographically defined areas of Sweden. Methods: In the health-care districts surrounding Skåne University Hospital (mean population 950 560) and Linköping University Hospital (mean population 428 503), all incident cases of HUV residing within the study areas at the onset of disease were identified during the years 2000-15...
April 30, 2018: Rheumatology
https://www.readbyqxmd.com/read/29668916/extraintestinal-manifestations-in-vedolizumab-and-anti-tnf-treated-patients-with-inflammatory-bowel-disease
#17
Marla C Dubinsky, Raymond K Cross, William J Sandborn, Millie Long, Xue Song, Nianwen Shi, Yao Ding, Samantha Eichner, Brandee Pappalardo, Arijit Ganguli, Anthony Wang
Background: Extra-intestinal manifestations (EIMs) can impact morbidity in patients with inflammatory bowel diseases (IBD; Crohn's disease [CD] and ulcerative colitis [UC]). This study compared incidence rates of EIMs in patients with moderate to severe IBD receiving gut-selective vedolizumab (VDZ) vs those receiving systemic anti-tumor necrosis factor (anti-TNF) therapies. Methods: Adult IBD patients receiving VDZ or anti-TNFs were identified from the MarketScan claims database from September 28, 2012, through September 30, 2016...
April 13, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29666122/iontophoretic-delivery-of-dexamethasone-phosphate-for-non-infectious-non-necrotising-anterior-scleritis-dose-finding-clinical-trial
#18
Erin C O'Neil, Jiayan Huang, Eric B Suhler, James P Dunn, Victor L Perez, David C Gritz, Kathy McWilliams, Ellen Peskin, Gui-Shuang Ying, Vatinee Y Bunya, Maureen G Maguire, John H Kempen
Currently available treatment options for non-infectious scleritis, including non-steroidal anti-inflammatory drugs, systemic corticosteroids and immunosuppressive therapies, have both efficacy and side effect limitations. Iontophoretic delivery of corticosteroids has been demonstrated to be effective for anterior uveitis and represents a potential new approach to scleritis therapy. We hypothesised that iontophoretic delivery would provide effective and precise medication delivery to the sclera, while limiting systemic exposure and side effects...
April 17, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29664747/scleral-patch-graft-with-a-suture-reinforcement-technique-in-surgical-management-of-necrotizing-scleritis-with-ectasia
#19
Joanne C Wen, Jocelyn Lam, Michael R Banitt
PURPOSE: To describe a technique for reducing and reinforcing scleral thinning in cases of necrotizing scleritis with ectasia. METHODS: Descriptive report of a surgical technique in 2 surgical cases with a video. RESULTS: Successful repair and reduction in uveal prolapse from scleral thinning in 2 cases of necrotizing scleritis with ectasia with a suturing technique using overlapping (weave) compressive suturing over a scleral patch. CONCLUSIONS: In cases of necrotizing scleritis with ectasia in which there is perforation or prolapsing uvea, this technique should be considered...
July 2018: Cornea
https://www.readbyqxmd.com/read/29656910/glycemic-control-is-an-important-modifiable-risk-factor-for-uveitis-in-patients-with-diabetes-a-retrospective-cohort-study-establishing-clinical-risk-and-ophthalmic-disease-burden
#20
Abdus Samad Ansari, Simon de Lusignan, William Hinton, Neil Munro, Simon Taylor, Andrew McGovern
AIM: To characterize the risk uveitis, scleritis or episcleritis in relation to diabetes, glycaemic control, and co-existence of retinopathy. METHODS: Using the Royal College of General Practitioners Research and Surveillance Centre database, we established the prevalence of acute uveitis and scleritis or episcleritis over a six-year period among populations without(n = 889,856) and with diabetes(n = 48,584). We evaluated the impact of glycaemic control on disease risk...
June 2018: Journal of Diabetes and its Complications
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