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https://www.readbyqxmd.com/read/29774953/dermoscopic-patterns-of-filiform-papillae-of-the-tongue-in-patients-with-and-without-connective-tissue-autoimmune-diseases
#1
José Manuel Díaz-González, María E Vega-Memije, Adalberto Mosqueda-Taylor, Víctor Noé García-Edgar, Juan Carlos Cuevas-González
BACKGROUND: Connective tissue autoimmune diseases (CTADs) constitute a group of conditions, including rheumatoid arthritis; systemic lupus erythematosus; mixed connective tissue disease; calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia (CREST) syndrome; scleroderma; dermatomyositis; and Sjögren syndrome. There are few studies on the alterations in filiform papillae in CTAD. Thus, the objective of this work was to determine whether there are changes in the macroscopic and dermoscopic patterns of filiform papillae...
May 18, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29760620/anti-endothelial-cell-antibodies-do-not-correlate-with-disease-activity-in-systemic-sclerosis
#2
Małgorzata Michalska-Jakubus, Małgorzata Kowal, Michał Adamczyk, Dorota Krasowska
Introduction: Anti-endothelial cell antibodies (AECA) recognize endothelial cell proteins and are thought to play an important role in vascular damage observed in systemic scleroderma (SSc) and many other autoimmune diseases. In SSc, AECA were found to be more common in patients with pulmonary hypertension, digital ulcers and nailfold capillaroscopic changes. Until now, there have been no studies examining the association between AECA positivity with the activity and duration of the disease...
April 2018: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29728522/muscular-and-extramuscular-clinical-features-of-patients-with-anti-pm-scl-autoantibodies
#3
Rebecca De Lorenzo, Iago Pinal-Fernandez, Wilson Huang, Jemima Albayda, Eleni Tiniakou, Cheilonda Johnson, Jose C Milisenda, Maria Casal-Dominguez, Andrea M Corse, Sonye K Danoff, Lisa Christopher-Stine, Julie J Paik, Andrew L Mammen
OBJECTIVE: To define the clinical features of myositis patients with anti-PM/Scl-75 and/or anti-PM/Scl-100 autoantibodies at disease onset and during the course of disease and compare them to patients with other forms of myositis. METHODS: In this longitudinal cohort study, the prevalence and severity of clinical features at disease onset and during follow-up were compared between anti-PM/Scl-positive patients and those with the antisynthetase syndrome (AS), dermatomyositis (DM), and immune-mediated necrotizing myopathy (IMNM)...
May 4, 2018: Neurology
https://www.readbyqxmd.com/read/29725520/multiple-scattered-and-small-lesions-of-lower-limbs-idiopathic-calcinosis-cutis-a-case-report
#4
N A Ferdaus-Kamudin, N H Mohamed-Haflah
Calcinosis cutis is a rare presentation and not many cases have been reported especially of idiopathic type. We are reporting a case of idiopathic calcinosis cutis of lower limbs in a 33-year old female who presented to our clinic for multiple painless swellings over her lower limbs for the past six months, without any history of trauma or infection. We have decided to observe her condition on regular follow-up and conservative management.
March 2018: Malaysian Orthopaedic Journal
https://www.readbyqxmd.com/read/29676330/lacrimal-punctal-and-peripunctal-involvement-in-calcinosis-cutis
#5
Nandini Bothra, Mohammad Javed Ali, Nikolaos Trakos, Milind N Naik
Calcinosis cutis is a rare metabolic disorder characterized by cutaneous and subcutaneous deposition of insoluble calcium salts. Ocular adnexal involvement is uncommon but mostly seen in males and in the upper eyelid. Solitary lesions are more common than multiple. The treatment of choice is excision biopsy. Histopathological examination provides a definitive diagnosis. Directed systemic investigations help to rule out underlying pathologies and aids further management. The present case reports the punctal and peripunctal involvement in a case of ocular adnexal calcinosis cutis...
May 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29622763/esophageal-mucosal-calcinosis-a-rare-site-of-gastrointestinal-mucosal-calcinosis
#6
Aaron R Huber, Brandon S Sprung, John Miller, Jennifer J Findeis-Hosey
BACKGROUND Gastrointestinal tract mucosal calcinosis (MC) tends to affect the gastric mucosa, while esophageal involvement is rare. Gastric MC may be seen with solid organ transplantation, use of aluminum-containing antacids or sucralfate, malignancy, and chronic renal failure. While the incidence of gastric MC in renal transplant patients undergoing gastric biopsy is common (between 15-29%), to our knowledge esophageal MC has only been previously reported 3 times. CASE REPORT A 68-year-old male dialysis-dependent end stage renal disease status-post deceased donor kidney transplant underwent an esophagogastroduodenoscopy (EGD) for dysphagia and diffuse esophageal wall thickening seen on imaging studies...
April 6, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29606827/scrotal-calcinosis-in-brothers
#7
Young Joon Park, Byung Woo Soh, You Chan Kim
No abstract text is available yet for this article.
April 2018: Annals of Dermatology
https://www.readbyqxmd.com/read/29602558/does-nailfold-capillaroscopy-help-predict-future-outcomes-in-systemic-sclerosis-a-systematic-literature-review
#8
REVIEW
Dolcie Paxton, John D Pauling
BACKGROUND: Nailfold capillaroscopy (NC) is an important diagnostic tool in systemic sclerosis (SSc). Confirmation of NC as a prognostic factor could facilitate earlier intervention and slow disease progression in SSc. We undertook a systematic literature review to evaluate the prognostic value of NC in predicting SSc disease progression. METHODS: Standardised searches of EMBASE and MEDLINE were undertaken to identify longitudinal studies of adult subjects with SSc reporting the prognostic value of NC for any aspect of disease progression and/or survival...
February 14, 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29598989/facial-calcinosis-cutis-in-a-woman-with-paraneoplastic-dermatomyositis
#9
M Herrero-Moyano, C Martínez-Mera, C García-García, E Dauden
No abstract text is available yet for this article.
March 26, 2018: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29594503/hyperphosphatemic-tumoral-calcinosis-caused-by-fgf23-compound-heterozygous-mutations-what-are-the-therapeutic-options-for-a-better-control-of-phosphatemia
#10
Debora Claramunt-Taberner, Aurélia Bertholet-Thomas, Marie-Christine Carlier, Frédérique Dijoud, Franck Chotel, Caroline Silve, Justine Bacchetta
BACKGROUND: Hyperphosphatemic familial tumoral calcinosis (HFTC) is a rare autosomal recessive disease caused by mutations in genes encoding FGF23 or its regulators, and leading to functional deficiency or resistance to fibroblast growth factor 23 (FGF23). Subsequent biochemical features include hyperphosphatemia due to increased renal phosphate reabsorption, and increased or inappropriately normal 1,25-dihydroxyvitamin D (1,25-D) levels. CASE-DIAGNOSIS/TREATMENT: A 15-year-old girl was referred for a 1...
March 28, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29584607/calcinosis-cutis-and-negative-pressure-wound-therapy-as-adjuncts-to-surgical-management-case-report-and-review-of-the-literature
#11
Florian Radu, Masaru Nishiaoki, Martine A Louis
Calcinosis cutis (CC), or calcium deposition in soft tissue, can cause significant morbidity associated with arthralgias and ulceration. This condition has an elusive pathophysiology and is often associated with autoimmune disorders, significantly impacting the disease burden. The clinical presentation of CC varies, and there is no gold standard treatment modality. The case of a 50-year-old woman with scleroderma and a rare presentation of milky drainage of a left hip ulcer secondary to underlying CC that was treated successfully with surgery and negative pressure wound therapy is reported herein...
March 2018: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29579373/calcinosis-of-the-mandible-in-dermatomyositis
#12
Andrea Fava, Lisa Christopher-Stine
A 52-year-old woman presented to the Rheumatology clinic complaining of new tender nodules along the inferior border of her jaw. She has an 8-year history of amyopathic dermatomyositis with anti-MDA5 antibodies complicated by interstitial lung disease. Her current treatments include tacrolimus, prednisone and hydroxychloroquine. She noticed the nodules during the most recent flare of her skin disease one month prior. On exam, she had 2 tender, hard, mobile nodules measuring approximately 5mm each located at 4cm and 2...
March 26, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29548779/dialysis-as-a-treatment-option-for-a-patient-with-normal-kidney-function-and-familial-tumoral-calcinosis-due-to-a-compound-heterozygous-fgf23-mutation
#13
Patrícia T Goldenstein, Precil D Neves, Bruno E Balbo, Rosilene M Elias, Alexandre C Pereira, Luiz F Onuchic, Harald Jüppner, Vanda Jorgetti, Hugo Abensur, Rosa Maria Moysés
Primary tumoral calcinosis is a rare autosomal recessive disorder characterized by ectopic calcified tumoral masses. Mutations in 3 genes (GALNT3, FGF23, and KL) have been linked to this human disorder. We describe a case of a 28-year-old man with a history of painful firm masses over his right and left gluteal region, right clavicle region, knees, and left elbow. Biochemical analysis disclosed hyperphosphatemia (phosphate, 9.0 mg/dL) and normocalcemia (calcium, 4.8 mg/dL), with normal kidney function and fractional excretion of phosphate of 3%...
March 14, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29546502/biocompatibility-of-new-materials-based-on-nano-structured-nitinol-with-titanium-and-tantalum-composite-surface-layers-experimental-analysis-in-vitro-and-in-vivo
#14
Mikhail A Sevost'yanov, Elena O Nasakina, Alexander S Baikin, Konstantin V Sergienko, Sergey V Konushkin, Mikhail A Kaplan, Alexey V Seregin, Alexander V Leonov, Valery A Kozlov, Alexey V Shkirin, Nikolai F Bunkin, Alexey G Kolmakov, Sergey V Simakov, Sergey V Gudkov
A technology for obtaining materials from nanostructured nitinol with titanium- or tantalum-enriched surface layers was developed. Surface layers enriched with titanium or tantalum were shown to provide a decrease in the formation of reactive oxygen species and long-lived protein radicals in comparison to untreated nitinol. It was determined that human peripheral vessel myofibroblasts and human bone marrow mesenchymal stromal cells grown on nitinol bases coated with titanium or tantalum-enriched surface layers exhibit a nearly two times higher mitotic index...
March 15, 2018: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29534337/differential-clinical-associations-of-anti-nuclear-matrix-protein-2-autoantibodies-in-patients-with-idiopathic-inflammatory-myopathies
#15
Hanbo Yang, Xin Lu, Qinglin Peng, Wei Jiang, Jingli Shi, Yamei Zhang, He Chen, Guochun Wang
OBJECTIVE: To investigate the associations between anti-NXP-2 autoantibody levels and disease activity as well as calcinosis severity. METHODS: The serum levels of anti-NXP-2 autoantibodies were determined in 709 idiopathic inflammatory myopathies (IIMs) and also serially measured by an in-house enzyme-linked immunosorbent assay using recombinant MORC3. Patients with anti-NXP-2 autoantibodies were divided into two subgroups: with or without calcinosis. The associations of anti-NXP-2 autoantibody levels with organ-specific disease activity, serum creatine kinase (CK) levels, and calcinosis severity were investigated in cross-sectional and longitudinal analyses...
March 13, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29532742/the-ability-of-fluorescence-angiography-to-detect-local-ischemia-in-patients-with-heel-ulceration
#16
Valerie S Marmolejo, Jonathan F Arnold
Heel ulcerations are a significant burden of care in both hospital and long-term care settings. The presence of peripheral arterial disease as a contributing factor to delayed healing is often not recognized, resulting in prolonged healing and high patient morbidity and mortality. Formal vascular evaluation and intervention is often not performed as these patients can have palpable pedal pulses while having localized ischemia of the heel. As routine noninvasive vascular studies can be affected by medial calcinosis and collateralization and do not specifically assess tissue perfusion to the heel, a false sense of security of adequate perfusion for healing can result...
June 2018: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/29525847/ultrasound-characterization-of-cutaneous-ulcers-in-systemic-sclerosis
#17
Yossra A Suliman, Suzanne Kafaja, John Fitzgerald, Ximena Wortsman, Jonathan Grotts, Marco Matucci-Cerrinic, Veena K Ranganath, Daniel E Furst
Skin ulcers in scleroderma (SSc) patients are considered a major challenge, both in clinical assessment and treatment decisions. The objective of our study is to assess ultrasonographic (US) morphology of skin ulcers in SSc patients and evaluate if US will be of value in enhancing our clinical information and influence our management plans. We examined a convenience sample of 21 skin ulcers reported in 10 SSc patients by US. We used a previously published US definition of normal skin and developed a preliminary US definition of skin ulcer...
June 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29512978/dermoscopic-features-of-milia-like-calcinosis-cutis
#18
Ilaria Proietti, Nicoletta Bernardini, Alessandra Mambrin, Ersilia Tolino, Massimiliano Mancini, Vincenzo Petrozza, Concetta Potenza
No abstract text is available yet for this article.
March 6, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29491659/multiple-asymptomatic-juxta-articular-nodules-mimicking-tuberous-xanthoma-a-unusual-presentation-of-tophaceous-gout
#19
Sidharth Tandon, Kabir Sardana, Purnima Malhotra, Jasmeet Singh
Asymptomatic, juxta-articular nodules are an uncommon morphology, which is usually diagnosed as xanthomas, calcinosis cutis or rheumatoid nodules. This study was represented as a case of gout, which is a disorder of purine metabolism resulting in elevation of serum uric acid and deposition of monosodium urate crystals within and around joints and manifests clinically as inflammatory arthritis. Urate crystal deposits have also been found in tendons, ligaments, viscera, and the skin, with the term "tophi" being used for the non-articular deposits...
October 2017: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/29490598/imaging-helps-guide-physical-therapy-treatment-in-a-patient-with-diffuse-systemic-sclerosis-scleroderma
#20
Rosemarie A Curley, Alycia Markowski
A 50-year-old woman with an 8-year history of diffuse systemic sclerosis, a form of scleroderma, was referred by her rheumatologist to physical therapy for decreased finger range of motion (ROM) and pain that adversely affected her dexterity and ability to perform activities of daily living. To determine whether joint mobilization would be appropriate for this patient, posterior-to-anterior and modified lateral radiographs of both hands were requested by the physical therapist. Images showed significant bone loss in the distal phalanges of both thumbs and in the left third and fourth digits, and calcinosis in the tips of both thumbs...
March 2018: Journal of Orthopaedic and Sports Physical Therapy
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