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https://www.readbyqxmd.com/read/29924910/differentiating-antiproliferative-and-chemopreventive-modes-of-activity-for-electron-deficient-aryl-isothiocyanates-against-human-mcf-7-cells
#1
Ruthellen H Anderson, Cody J Lensing, Benjamin J Forred, Michael W Amolins, Cassandra L Aegerter, Peter F Vitiello, Jared R Mays
Consumption of Brassica vegetables provides beneficial effects due to organic isothiocyanates (ITCs), a resultant product of the enzymatic hydrolysis of glucosinolate secondary metabolites. The ITC L-sulforaphane (L-SFN) is the principle agent in broccoli that demonstrates several modes of anticancer action. While the anticancer properties of ITCs like L-SFN have been extensively studied and L-SFN has been the subject of multiple human clinical trials, the scope of this work has largely been limited to those derivatives found in nature...
June 20, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29923998/clinical-study-on-postoperative-triple-negative-breast-cancer-with-chinese-medicine-study-protocol-for-an-observational-cohort-trial
#2
Jiajing Chen, Yuenong Qin, Chenping Sun, Wei Hao, Shuai Zhang, Yi Wang, Juan Chen, Lixin Chen, Yiying Ruan, Sheng Liu
BACKGROUND: Breast cancer (BC) poses a tremendous threat to the health of women worldwide, especially triple-negative breast cancers (TNBCs). Currently, the curative effect of traditional Chinese medicine (TCM) has been recognized in more and more people worldwide; however, the specific effect has not been systematically evaluated. The purpose of this cohort study is to evaluate the clinical effects of TCM syndrome differentiation on recurrence and metastasis rate, survival rate, and the quality of life in patients with TNBC...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29923188/stop-routine-screening-for-associated-malignancies-in-cutaneous-non-invasive-vulvar-paget-disease
#3
M van der Linden, M S Schuurman, J Bulten, L F A G Massuger, J IntHout, M A van der Aa, J A de Hullu
BACKGROUND: Vulvar Paget disease (VPD) is extremely rare and thought to be associated with other malignancies. OBJECTIVE: The aim of this study was to evaluate the risk of developing breast, intestinal, and urological malignancies in patients with VPD compared with the general population, and in particular focus on the risk of malignancy in patients with cutaneous non-invasive VPD. METHODS: Data on the oncologic history of patients with any type of VPD between 2000 and 2015 were obtained from PALGA, a nationwide archive containing all pathology reports in the Netherlands...
June 19, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29922090/extramedullary-hematopoiesis-secondary-to-malignant-solid-tumors-a-case-report-and-literature-review
#4
Youting Bao, Zhichao Liu, Meiying Guo, Butuo Li, Xindong Sun, Linlin Wang
Extramedullary hematopoiesis (EMH) usually occurs in hematological disease, but more rarely develops in cases of malignant solid tumors. Due to its features on computed tomography (CT) and magnetic resonance imaging (MRI) that are atypical, EMH in tumor patients might easily be misdiagnosed as metastasis leading to the improper TNM staging and inappropriate therapy. Here, we reported the first case of pleural EMH occurring in a patient with esophageal carcinoma whose pleural lesion was first diagnosed as metastasis and confirmed EMH after the needle biopsy...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29915723/bovine-milk-lactoferrin-selectively-kills-highly-metastatic-prostate-cancer-pc-3-and-osteosarcoma-mg-63-cells-in-vitro
#5
Joana P Guedes, Cátia S Pereira, Lígia R Rodrigues, Manuela Côrte-Real
Prostate cancer and osteosarcoma are the second most common type of cancer affecting men and the fifth most common malignancy among adolescents, respectively. The use of non-toxic natural or natural-derived products has been one of the current strategies for cancer therapy, owing to the reduced risks of induced-chemoresistance development and the absence of secondary effects. In this perspective, lactoferrin (Lf), a natural protein derived from milk, emerges as a promising anticancer agent due to its well-recognized cytotoxicity and anti-metastatic activity...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29914648/long-term-risks-of-secondary-cancer-for-various-whole-and-partial-breast-irradiation-techniques
#6
Nienke Hoekstra, Emmanuelle Fleury, Tomas Rodrigo Merino Lara, Peter van der Baan, Andy Bahnerth, Gerson Struik, Mischa Hoogeman, Jean-Philippe Pignol
INTRODUCTION: For early stage breast cancer patients, non-breast cancer mortality including secondary cancers and cardiac events can overshadow the benefit of adjuvant radiotherapy. This study evaluates the excess risk of secondary cancer for various breast radiotherapy techniques including accelerated partial breast irradiation (APBI). METHODS: Secondary cancers Lifetime Attributable Risks (LAR) were calculated using a modified BEIR-VII formalism to account for the specific survival of breast cancer patients...
June 15, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29914494/development-of-an-exercise-intervention-for-the-prevention-of-musculoskeletal-shoulder-problems-after-breast-cancer-treatment-the-prevention-of-shoulder-problems-trial-uk-prosper
#7
Helen Richmond, Clare Lait, Cynthia Srikesavan, Esther Williamson, Jane Moser, Meredith Newman, Lauren Betteley, Beth Fordham, Sophie Rees, Sarah E Lamb, Julie Bruce
BACKGROUND: Musculoskeletal shoulder problems are common after breast cancer treatment. There is some evidence to suggest that early postoperative exercise is safe and may improve shoulder function. We describe the development and delivery of a complex intervention for evaluation within a randomised controlled trial (RCT), designed to target prevention of musculoskeletal shoulder problems after breast cancer surgery (The Prevention of Shoulder Problems Trial; PROSPER). METHODS: A pragmatic, multicentre RCT to compare the clinical and cost-effectiveness of best practice usual care versus a physiotherapy-led exercise and behavioural support intervention in women at high risk of shoulder problems after breast cancer treatment...
June 18, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29909105/rationale-and-design-of-the-strain-surveillance-of-chemotherapy-for-improving-cardiovascular-outcomes-succour-trial
#8
Tomoko Negishi, Paaladinesh Thavendiranathan, Kazuaki Negishi, Thomas H Marwick
OBJECTIVES: This study sought to evaluate the hypothesis that global longitudinal strain (GLS) guidance of cardioprotective therapy would improve cardiac function of at-risk patients undergoing potentially cardiotoxic chemotherapy, compared with usual care. BACKGROUND: The conventional criteria for diagnosis of chemotherapy-related cardiac dysfunction (CTRCD) are dependent on the recognition of heart failure symptoms and/or changes in left ventricular ejection fraction...
June 8, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29908524/neoadjuvant-radiotherapy-changing-the-treatment-sequence-to-allow-immediate-free-autologous-breast-reconstruction
#9
Kimberley Hughes, Derek Neoh
BACKGROUND:  Locally advanced breast cancer (LABC) is traditionally treated with a multimodal approach of chemotherapy, surgery, and postmastectomy radiotherapy (PMRT). The advantages of immediate breast reconstruction (IBR) are well described and include improved aesthetic outcomes, fewer surgical procedures, shorter treatment period, and a higher quality of life. However, this sequence makes immediate free autologous reconstruction more challenging as PMRT can have deleterious and unpredictable effects on the flap...
June 16, 2018: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29908344/nitroxide-radical-containing-nanoparticles-attenuate-tumorigenic-potential-of-triple-negative-breast-cancer
#10
Babita Shashni, Yukio Nagasaki
The critical importance of reactive oxygen species (ROS) as oncogene activators and essential secondary messengers in cancer cell survival have been widely reported. Since oxidative stress has been implicated as being pivotal in various cancers, antioxidant therapy seems an apt strategy to abrogate ROS-mediated cellular processes to attenuate cancers. We therefore synthesized ROS scavenging nitroxide radical-containing nanoparticles (RNPs); pH insensitive RNPO and pH sensitive RNPN , to impede the proliferative and metastatic characteristics of the triple negative breast cancer cell line, MDA-MB-231, both in vitro and in vivo...
May 26, 2018: Biomaterials
https://www.readbyqxmd.com/read/29904382/retinoic-acid-receptor-related-orphan-receptors-critical-roles-in-tumorigenesis
#11
REVIEW
Jinshuo Fan, Zhilei Lv, Guanghai Yang, Ting Ting Liao, Juanjuan Xu, Feng Wu, Qi Huang, Mengfei Guo, Guorong Hu, Mei Zhou, Limin Duan, Shuqing Liu, Yang Jin
Retinoic acid receptor-related orphan receptors (RORs) include RORα (NR1F1), RORβ (NR1F2), and RORγ (NR1F3). These receptors are reported to activate transcription through ligand-dependent interactions with co-regulators and are involved in the development of secondary lymphoid tissues, autoimmune diseases, inflammatory diseases, the circadian rhythm, and metabolism homeostasis. Researches on RORs contributing to cancer-related processes have been growing, and they provide evidence that RORs are likely to be considered as potential therapeutic targets in many cancers...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29902299/association-of-t-cell-receptor-repertoire-use-with-response-to-combined-trastuzumab-lapatinib-treatment-of-her2-positive-breast-cancer-secondary-analysis-of-the-neoaltto-randomized-clinical-trial
#12
Ryan L Powles, David Redmond, Christos Sotiriou, Sherene Loi, Debora Fumagalli, Paolo Nuciforo, Nadia Harbeck, Evandro de Azambuja, Severine Sarp, Serena Di Cosimo, Jens Huober, Jose Baselga, Martine Piccart-Gebhart, Olivier Elemento, Lajos Pusztai, Christos Hatzis
Importance: Dual anti-HER2 blockade increased the rate of pathologic complete response (pCR) in the Neoadjuvant Lapatinib and/or Trastuzumab Treatment Optimisation (NeoALTTO) trial, and high immune gene expression was associated with pCR in all treatment arms. So far, no marker has been identified that is specifically associated with the benefit from dual HER2 blockade. Objective: To examine if use of the T-cell β chain variable genes adds to the potential association of immune gene signatures with response to dual HER2 blockade...
June 14, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29902286/association-of-somatic-driver-alterations-with-prognosis-in-postmenopausal-hormone-receptor-positive-her2-negative-early-breast-cancer-a-secondary-analysis-of-the-big-1-98-randomized-clinical-trial
#13
Stephen J Luen, Rebecca Asher, Chee Khoon Lee, Peter Savas, Roswitha Kammler, Patrizia Dell'Orto, Olivia Maria Biasi, David Demanse, Lellean JeBailey, Sinead Dolan, Wolfgang Hackl, Beat Thuerlimann, Giuseppe Viale, Marco Colleoni, Meredith M Regan, Sherene Loi
Importance: A range of somatic driver alterations has been described in estrogen receptor-positive, HER2-negative (ER+/HER2-) early breast cancer (BC); however, the clinical relevance is unknown. Objective: To investigate associations of driver alterations with prognosis and the role of PIK3CA mutations in prediction of benefit associated with endocrine therapy in postmenopausal patients with ER+/HER2- early BC treated with tamoxifen or letrozole. Design, Setting, and Participants: The Breast International Group (BIG) 1-98 trial randomized 8010 postmenopausal patients with hormone receptor-positive, operable, invasive BC to monotherapy with letrozole, tamoxifen, or a sequential strategy for 5 years...
June 14, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29900185/portable-impulse-radar-detector-for-breast-cancer-a-pilot-study
#14
Shinsuke Sasada, Norio Masumoto, Hang Song, Keiko Kajitani, Akiko Emi, Takayuki Kadoya, Koji Arihiro, Takamaro Kikkawa, Morihito Okada
Microwave breast imaging is a painless and nonradiation method. This pilot study aimed to evaluate the detective capability and feasibility of a prototype of a portable breast cancer detector using a radar-based imaging system. Five patients with histologically confirmed breast cancers with a minimum diameter of 1 cm were enrolled in this study. The antenna array dome of the device was placed on the breast of the patient in a supine position for 15 min per single examination. The primary endpoint was a detection rate of breast cancers...
April 2018: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29896404/primary-breast-cancer-relapse-as-metastasis-to-the-cervix-uteri-a-case-report
#15
Aude Thouvenot, Yasmine Bizet, Laurent S Baccar, Michele Lamuraglia
Metastasis of non-gynaecological tumours to the cervix is a rare event, and metastasis from breast cancer is even rarer, with only a limited number of such cases reported in the literature to date. We herein report the case of an 86-year-old female patient who had undergone mastectomy and axillary lymphadenectomy for invasive ductal cell breast carcinoma 2 years prior, followed by adjuvant hormonal therapy with letrozole. During hospitalization for anemia associated with an inflammatory syndrome and abdominal pain with menorrhagia, an abdominal ultrasound examination revealed a suspicious uterine mass with irregular contours and abnormal vascularization with associated increase of the blood level of cancer antigen 15-3 to 34 kU/l...
July 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29893791/trastuzumab-versus-observation-for-her2-non-amplified-early-breast-cancer-with-circulating-tumor-cells-eortc-90091-10093-big-1-12-treat-ctc-a-randomized-phase-2-trial
#16
M Ignatiadis, S Litière, F Rothe, S Riethdorf, C Proudhon, T Fehm, K Aalders, H Forstbauer, P Fasching, E Brain, P Vuylsteke, E Guardiola, R Lorenz, K Pantel, K Tryfonidis, W Janni, M Piccart, C Sotiriou, B Rack, J-Y Pierga
Background: Trastuzumab improves the outcome of women with HER2 positive breast cancer. We aimed to assess whether trastuzumab decreases the detection rate of Circulating Tumor Cells (CTCs) in women with high risk, HER2 non-amplified, early breast cancer. Patients and Methods: The EORTC 90091-10093 BIG 1-12 Treat CTC is a phase 2 trial, conducted in 70 hospitals and 6 CTC laboratories across 5 European countries. Patients with centrally confirmed HER2 non-amplified breast cancer and ≥1 centrally confirmed CTC per 15mL of blood by CellSearch® following surgery and (neo)adjuvant chemotherapy were randomized (1:1) to 6 cycles of trastuzumab intravenously versus 18 weeks of observation...
June 11, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29893790/palbociclib-as-single-agent-or-in-combination-with-the-endocrine-therapy-received-before-disease-progression-for-estrogen-receptor-positive-her2-negative-metastatic-breast-cancer-trend-trial
#17
L Malorni, G Curigliano, A M Minisini, S Cinieri, C A Tondini, K D'Hollander, G Arpino, A Bernardo, A Martignetti, C Criscitiello, F Puglisi, M Pestrin, G Sanna, E Moretti, E Risi, C Biagioni, A McCartney, L Boni, M Buyse, I Migliaccio, L Biganzoli, A Di Leo
Background: The activity of palbociclib as a single agent in advanced breast cancer has not been extensively studied, with the only available clinical data limited to heavily pre-treated patients. Pre-clinical data suggests palbociclib may partially reverse endocrine resistance, though this hypothesis has not been evaluated in previous clinical studies. This phase II, open-label, multi-center study examined the activity of palbociclib monotherapy, as well as palbociclib given in combination with the same endocrine therapy (ET) that was received prior to disease progression, in post-menopausal women with moderately pre-treated, estrogen receptor-positive, HER2 negative advanced breast cancer...
June 11, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29893769/modulation-of-rb-phosphorylation-and-antiproliferative-response-to-palbociclib-the-preoperative-palbociclib-pop-randomized-clinical-trial
#18
M Arnedos, M A Bayar, B Cheaib, V Scott, I Bouakka, A Valent, J Adam, V Leroux-Kozal, V Marty, A Rapinat, C Mazouni, B Sarfati, I Bieche, C Balleyguier, D Gentien, S Delaloge, M Lacroix-Triki, S Michiels, F Andre
Background: The CDK4/6 inhibitor Palbociclib is a new standard treatment in hormone-receptor positive breast cancer patients. No predictive biomarkers have been identified and no pharmacodynamics has properly been described so far. Patients and methods: Patients with early breast cancer were randomized 3:1 to oral palbociclib 125mg daily for 14 days until the day before the surgery vs. no treatment. Primary objective was antiproliferative response defined as a natural logarithm of Ki67 expression at day 15 below 1...
June 11, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29893331/assessment-of-accuracy-of-out-of-field-dose-calculations-by-tigrt-treatment-planning-system-in-radiotherapy
#19
Mohammad Taghi Bahreyni Toossi, Shokouhozaman Soleymanifard, Bagher Farhood, Shokoufeh Mohebbi, David Davenport
Aim: The objective was to quantify the accuracy of dose calculation for out-of-field regions by the commercially available TiGRT version 1.2 (LinaTech, Sunnyvale, CA, USA) treatment planning system (TPS) for a clinical treatment delivered on a Siemens Primus with the single energy of 6 MV. Materials and Methods: Two tangential open fields were planned by TiGRT TPS to irradiate the left breast of a RANDO phantom. Dose values to out-of-field points were calculated by TiGRT TPS...
April 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29891105/are-mammographically-occult-additional-tumors-identified-more-than-2-cm-away-from-the-primary-breast-cancer-on-mri-clinically-significant
#20
Sarah Goodman, Victoria Mango, Lauren Friedlander, Elise Desperito, Ralph Wynn, Richard Ha
RATIONALE AND OBJECTIVES: To evaluate the clinical significance of mammographically occult additional tumors identified more than 2cm away from the primary breast cancer on preoperative magnetic resonance imaging (MRI). MATERIALS AND METHODS: An Institutional Review Board approved review of consecutive preoperative breast MRIs performed from 1/1/08 to 12/31/14, yielded 667 patients with breast cancer. These patients underwent further assessment to identify biopsy proven mammographically occult breast tumors located more than 2cm away from the edge of the primary tumor...
June 8, 2018: Academic Radiology
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