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https://www.readbyqxmd.com/read/28213599/health-information-needs-source-preferences-and-engagement-behaviours-of-women-with-metastatic-breast-cancer-across-the-care-continuum-protocol-for-a-scoping-review
#1
Carol A Tucker, M Pilar Martin, Ray B Jones
INTRODUCTION: The health information needs, information source preferences and engagement behaviours of women with metastatic breast cancer (mBC) depend on personal characteristics such as education level, prior knowledge, clinical complications, comorbidities and where they are in the cancer journey. A thorough understanding of the information behaviours of women living with mBC is essential to the provision of optimal care. A preliminary literature review suggests that there is little research on this topic, but that there may be lessons from a slightly broader literature...
February 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28199174/role-of-troponins-i-and-t-and-n-terminal-prohormone-of-brain-natriuretic-peptide-in-monitoring-cardiac-safety-of-patients-with-early-stage-human-epidermal-growth-factor-receptor-2-positive-breast-cancer-receiving-trastuzumab-a-herceptin-adjuvant-study-cardiac
#2
Dimitrios Zardavas, Thomas M Suter, Dirk J Van Veldhuisen, Jutta Steinseifer, Johannes Noe, Sabine Lauer, Nedal Al-Sakaff, Martine J Piccart-Gebhart, Evandro de Azambuja
Purpose Women receiving trastuzumab with chemotherapy are at risk for trastuzumab-related cardiac dysfunction (TRCD). We explored the prognostic value of cardiac markers (troponins I and T, N-terminal prohormone of brain natriuretic peptide [NT-proBNP]) to predict baseline susceptibility to develop TRCD. We examined whether development of cardiac end points or significant left ventricular ejection fraction (LVEF) drop was associated with markers' increases. Patients and Methods Cardiac marker assessments were coupled with LVEF measurements at different time points for 533 patients from the Herceptin Adjuvant (HERA) study who agreed to participate in this study...
October 23, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28197635/fluid-shear-stress-induces-cancer-stem-cell-like-phenotype-in-mcf7-breast-cancer-cell-line-without-inducing-epithelial-to-mesenchymal-transition
#3
Ursula L Triantafillu, Seungjo Park, Nikki L Klaassen, Andrew D Raddatz, Yonghyun Kim
Metastasis is the leading cause of cancer deaths due to the spread of cancer cells through the blood vessels and the subsequent formation of secondary tumors. Metastasizing cancer cells in the human vasculature are called circulating tumor cells (CTCs) and are characterized to express the epithelial cell adhesion molecule (EpCAM). They are further known to survive physiological fluid shear stress (FSS) conditions. However, the effect of FSS on CTC molecular phenotype, such as the epithelial to mesenchymal transition (EMT) and cancer stem cell (CSC) expression, has not been extensively studied...
January 30, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28196771/liver-metastases-from-breast-cancer-what-role-for-surgery-indications-and-results
#4
REVIEW
Nicolas Golse, René Adam
Liver metastases from breast cancer (LMBC) have long been considered as a systemic disease because of the hematological route of dissemination, requiring noncurative management. In fact, despite recent advances in drug therapies personalized to tumor phenotype, the chances of a cure are nil and there is little hope of long-term survivors after nonsurgical management alone. By contrast, there is a growing evidence in the literature for satisfactory long-term results after a combination of chemotherapy and liver resection, with 5-year survival reaching >40% in some series...
January 9, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28196254/effect-of-a-scalp-cooling-device-on-alopecia-in-women-undergoing-chemotherapy-for-breast-cancer-the-scalp-randomized-clinical-trial
#5
Julie Nangia, Tao Wang, Cynthia Osborne, Polly Niravath, Kristen Otte, Steven Papish, Frankie Holmes, Jame Abraham, Mario Lacouture, Jay Courtright, Richard Paxman, Mari Rude, Susan Hilsenbeck, C Kent Osborne, Mothaffar Rimawi
Importance: Chemotherapy may induce alopecia. Although scalp cooling devices have been used to prevent this alopecia, efficacy has not been assessed in a randomized clinical trial. Objectives: To assess whether a scalp cooling device is effective at reducing chemotherapy-induced alopecia and to assess adverse treatment effects. Design, Setting, and Participants: Multicenter randomized clinical trial of women with breast cancer undergoing chemotherapy...
February 14, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28195994/an-internet-based-cognitive-behavioral-therapy-for-treatment-induced-menopausal-symptoms-in-breast-cancer-survivors-results-of-a-pilot-study
#6
Vera Atema, Marieke van Leeuwen, Hester S A Oldenburg, Marc van Beurden, Myra S Hunter, Neil K Aaronson
OBJECTIVE: Previous studies demonstrated that a cognitive behavioral therapy (CBT) program delivered in group sessions is effective in alleviating treatment-induced menopausal symptoms in women with breast cancer, but also that in-person CBT is inconvenient for some women and can result in low levels of program compliance. A promising, alternative approach is to use the Internet to make this form of CBT more accessible and feasible for patients. The objective of this study was to evaluate the feasibility and to generate preliminary data on the efficacy of a guided, Internet-based CBT program...
February 13, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28193617/prescribing-tamoxifen-in-primary-care-for-the-prevention-of-breast-cancer-a-national-online-survey-of-gps-attitudes
#7
Samuel G Smith, Robbie Foy, Jennifer A McGowan, Lindsay C Kobayashi, Andrea de Censi, Karen Brown, Lucy Side, Jack Cuzick
BACKGROUND: The cancer strategy for England (2015-2020) recommends GPs prescribe tamoxifen for breast cancer primary prevention among women at increased risk. AIM: To investigate GPs' attitudes towards prescribing tamoxifen. DESIGN AND SETTING: In an online survey, GPs in England, Northern Ireland, and Wales (n = 928) were randomised using a 2 × 2 between-subjects design to read one of four vignettes describing a healthy patient seeking a tamoxifen prescription...
February 13, 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/28192742/breast-cancer-detection-using-single-reading-of-breast-tomosynthesis-3d-mammography-compared-to-double-reading-of-2d-mammography-evidence-from-a-population-based-trial
#8
Nehmat Houssami, Daniela Bernardi, Marco Pellegrini, Marvi Valentini, Carmine Fantò, Livio Ostillio, Paolina Tuttobene, Andrea Luparia, Petra Macaskill
BACKGROUND: Most population breast cancer (BC) screening programs use double-reading of 2D-mammography. We recently reported the screening with tomosynthesis or standard mammography-2 (STORM-2) trial, showing that double-read tomosynthesis (pseudo-3D-mammography) detected more BC than double-read 2D-mammography. In this study, we compare screen-detection measures for single-reading of 3D-mammography with those for double-reading of 2D-mammography, to inform screening practice. METHODS: This is a secondary analysis based on STORM-2 which prospectively compared 3D-mammography and 2D-mammography in sequential screen-readings...
February 10, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28192598/overall-survival-and-the-response-to-radiotherapy-among-molecular-subtypes-of-breast-cancer-brain-metastases-treated-with-targeted-therapies
#9
Jacob A Miller, Rupesh Kotecha, Manmeet S Ahluwalia, Alireza M Mohammadi, Samuel T Chao, Gene H Barnett, Erin S Murphy, Michael A Vogelbaum, Lilyana Angelov, David M Peereboom, John H Suh
BACKGROUND: The current study was conducted to investigate survival and the response to radiotherapy among patients with molecular subtypes of breast cancer brain metastases treated with or without targeted therapies. METHODS: Patients diagnosed with breast cancer brain metastases at a single tertiary care institution were included. The primary outcome was overall survival, whereas secondary outcomes included the cumulative incidences of distant intracranial failure, local failure, and radiation necrosis...
February 13, 2017: Cancer
https://www.readbyqxmd.com/read/28189100/the-impact-of-exercise-during-adjuvant-radiotherapy-for-breast-cancer-on-fatigue-and-quality-of-life-a-systematic-review-and-meta-analysis
#10
REVIEW
Andrea Lipsett, Sarah Barrett, Fatimah Haruna, Karen Mustian, Anita O'Donovan
PURPOSE: Adjuvant radiation therapy (RT) in breast cancer treatment has been proven to enhance outcome, improving recurrence and mortality rates. RT, however, gives rise to unfavourable side-effects, fatigue the most frequent. The aim of this study was to assess the effect of exercise (and different exercise prescription parameters) during adjuvant RT on fatigue among breast cancer patients. Quality of life was a secondary outcome. SEARCH METHODOLOGY AND SELECTION CRITERIA: Randomised controlled trials that investigated the effect of exercise during adjuvant RT on fatigue for breast cancer patients were searched using MEDLINE, EMBASE, Google Scholar, CINAHL, AMED and ClinicalTrials...
February 8, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28185119/biallelic-brca2-mutations-in-two-black-south-african-children-with-fanconi-anaemia
#11
Candice Feben, Careni Spencer, Anneline Lochan, Nakita Laing, Karen Fieggen, Engela Honey, Tasha Wainstein, Amanda Krause
Fanconi anaemia (FA) is a genotypically and phenotypically heterogeneous genetic condition, characterized cytogenetically by chromosomal instability and breakage secondary to impaired DNA repair mechanisms. Affected individuals typically manifest growth restriction and congenital physical abnormalities and most progress to hematological disease including bone marrow aplasia. A rare genetic subtype of FA (FA-D1) is caused by biallelic mutations in the BRCA2 gene. Affected individuals manifest severe congenital anomalies and significant pigmentary changes and are additionally at risk for early onset leukemia and certain solid organ malignancies, including Wilms tumors and brain tumors...
February 9, 2017: Familial Cancer
https://www.readbyqxmd.com/read/28184263/a-low-dose-of-droperidol-decreases-the-desflurane-concentration-needed-during-breast-cancer-surgery-a-randomized-double-blinded-study
#12
Maiko Satomoto, Yushi U Adachi, Koshi Makita
BACKGROUND: Droperidol (DHB) reportedly reduces the dose of propofol needed to achieve hypnosis when anesthesia is induced and decreases the bispectral index (BIS) in propofol-sedated patients during spinal anesthesia. We reported previously that supplemental DHB decreased the BIS after the administration of sevoflurane and remifentanil. This study investigated the effect of DHB on desflurane (DES) consumption in a clinical setting. METHODS: We conducted a prospective, randomized double-blinded study of 35 women with American Society of Anesthesiologist physical status I or II who underwent a mastectomy...
February 2017: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/28181805/lissoclibadin-1-a-polysulfur-aromatic-alkaloid-from-the-indonesian-ascidian-lissoclinum-cf-badium-induces-caspase-dependent-apoptosis-in-human-colon-cancer-cells-and-suppresses-tumor-growth-in-nude-mice
#13
Takeo Tatsuta, Masahiro Hosono, Henki Rotinsulu, Defny S Wewengkang, Deiske A Sumilat, Michio Namikoshi, Hiroyuki Yamazaki
Lissoclibadins, polysulfur aromatic alkaloids, were isolated from the Indonesian ascidian Lissoclinum cf. badium. Lissoclibadins 1 (1), 3 (2), 4 (3), 7 (4), 8 (5), and 14 (6) inhibited the growth of four human solid cancer cell lines: HCT-15 (colon adenocarcinoma), HeLa-S3 (cervix adenocarcinoma), MCF-7 (breast adenocarcinoma), and NCI-H28 (mesothelioma). Lissoclibadin 1 (1) exerted the most potent cytotoxic effects in vitro and mainly promoted apoptosis through an intrinsic pathway with the activation of a caspase-dependent pathway in HCT-15 cells...
February 9, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28181131/randomized-trial-of-aromatherapy-versus-conventional-care-for-breast-cancer-patients-during-perioperative-periods
#14
Kentaro Tamaki, Akiko Komatsu Fukuyama, Shigeharu Terukina, Yoshihiko Kamada, Kano Uehara, Miwa Arakaki, Kazuko Yamashiro, Minoru Miyashita, Takanori Ishida, Keely May McNamara, Noriaki Ohuchi, Nobumitsu Tamaki, Hironobu Sasano
PURPOSE: Several studies focused on the effect of aromatherapy on mood, quality of life (QOL), and physical symptoms in patients with cancer. We compared the effects on QOL, vital signs, and sleep quality between aromatherapy and conventional therapy during perioperative periods of the breast cancer patients in this study. METHODS: Patients were randomly assigned in a 2:1 ratio to receive aromatherapy or usual care. The primary endpoint was QOL, which was assessed using the quality of life questionnaire QLQ-C30, Version 3...
February 8, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28178714/liver-directed-embolization-for-the-long-term-control-of-hypercalcemia-of-malignancy-in-metastatic-breast-cancer
#15
Sowmya Nanjappa, Carlos A Pla-Fernandez, Susmitha Apuri, Loretta Loftus, Bela Kis
Hypercalcemia of malignancy is a common complication of certain types of cancers. No standard therapies exist for the treatment of hypercalcemia secondary to paraneoplastic syndromes that result in the long-term control of serum calcium levels. We report a case of metastatic breast cancer with parathyroid hormone-related protein associated with hypercalcemia of malignancy that was treated with transarterial embolization of the hepatic metastatic lesions.
January 2017: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/28177921/axillary-staging-in-breast-cancer-patients-treated-with-neoadjuvant-chemotherapy-in-two-dutch-phase-iii-studies
#16
Birgit E P J Vriens, Kristien B M I Keymeulen, Judith R Kroep, Ayoub Charehbili, Petronella G Peer, Maaike de Boer, Maureen J B Aarts, Esther M Heuts, Vivianne C G Tjan-Heijnen, The Dutch Breast Cancer Research Group Boog
BACKGROUND: Primary aim of our study was to assess the impact of timing of sentinel node procedure, pre- versus post-neoadjuvant chemotherapy, on final pathologic node-negative rate (pN0) in patients with clinically node-negative (cN0) breast cancer. Secondary endpoint was the usability of the sentinel node procedure in patients with clinically node-positive disease that converted to cN0 after neoadjuvant chemotherapy. PATIENTS AND METHODS: Patients were enrolled in two sequentially conducted Dutch phase III trials, studying the impact of two neoadjuvant chemotherapy schedules and use of zoledronic acid on complete pathologic response rate...
February 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28176013/impact-of-reproductive-factors-on-breast-cancer-subtypes-in-postmenopausal-women-a-retrospective-single-center-study
#17
Alexandra von Au, Mona Klotzbuecher, Lorenz Uhlmann, Mark Boudewijns, Laura Michel, Markus Wallwiener, Joerg Heil, Michael Golatta, Joachim Rom, Christof Sohn, Andreas Schneeweiss, Florian Schuetz, Christoph Domschke
PURPOSE: Some reproductive factors are well-known general risk factors for breast cancer (BC). On the other hand, BC subtypes also have a high prognostic value. Correlations, however, that link these risk factors to the development of a particular one of the different BC subtypes are still poorly understood. The primary objective of our study was to assess the influence of different reproductive factors (duration of breastfeeding, parity, and age at first childbirth) on pathological BC subtypes...
February 7, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28174484/non-anthracycline-containing-docetaxel-and-cyclophosphamide-regimen-is-associated-with-sustained-worse-outcome-compared-with-docetaxel-anthracycline-and-cyclophosphamide-in-neoadjuvant-treatment-of-triple-negative-and-her2-positive-breast-cancer-patients-updated
#18
Xiaosong Chen, Guolin Ye, Chenfang Zhang, Xinzheng Li, Kunwei Shen
OBJECTIVE: A previous study demonstrated that non-anthracycline-containing docetaxel plus cyclophosphamide (TC) regimen was inferior to docetaxel, anthracycline and cyclophosphamide (TAC) in neoadjuvant treatment of triple-negative breast cancer (TNBC) and human epidermal growth factor receptor-2-(HER2)-positive breast cancer in a short-term follow-up. Herein, long-term follow-up survival outcomes have been investigated. METHODS: TNBC or HER2-positive patients were randomized to receive 6 cycles of TC or TAC neoadjuvant treatment...
December 2016: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/28169209/place-of-death-for-hospice-cared-terminal-patients-with-cancer-a-nationwide-retrospective-study-in-taiwan
#19
Heng-Yi Lin, Shih-Chao Kang, Yu-Chun Cheng, Yin-Chieh Chang, Wei-Shu Wang, Su-Shun Lo
BACKGROUND: Hospice care has been part of the Taiwan health-care system for 20 years. Detailed information on the place of death for terminal cancer patients is lacking. Impending death discharge (IDD) is unique in Taiwan, and our study aims to compare IDD with in-hospice death among terminal cancer patients under hospice care. METHODS: This retrospective study used claims data of decedents of cancer from the National Health Insurance Research Database of Taiwan from 2007 to 2010...
February 3, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28166765/optitrain-a-randomised-controlled-exercise-trial-for-women-with-breast-cancer-undergoing-chemotherapy
#20
Y Wengström, K A Bolam, S Mijwel, C J Sundberg, M Backman, M Browall, J Norrbom, H Rundqvist
BACKGROUND: Women with breast cancer undergoing chemotherapy suffer from a range of detrimental disease and treatment related side-effects. Exercise has shown to be able to counter some of these side-effects and improve physical function as well as quality of life. The primary aim of the study is to investigate and compare the effects of two different exercise regimens on the primary outcome cancer-related fatigue and the secondary outcomes muscle strength, function and structure, cardiovascular fitness, systemic inflammation, skeletal muscle gene activity, health related quality of life, pain, disease and treatment-related symptoms in women with breast cancer receiving chemotherapy...
February 6, 2017: BMC Cancer
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