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https://www.readbyqxmd.com/read/29325353/-comparison-of-the-short-term-and-long-term-outcome-between-robotic-gastrectomy-and-laparoscopic-gastrectomy-a-propensity-score-matching-analysis
#1
K C Zhang, B Wei, H Q Xi, J X Cui, J Y Li, Y H Gao, W Q Liang, C Hu, Y Liu, X H Huang, L Chen
Objective: To compare the short-term and long-term outcome between robotic gastrectomy and laparoscopic gastrectomy. Methods: The clinical data of 517 patients who had received robotic gastectomy and laparoscopic gastrectomy between December 2011 and December 2013 at Department of General Surgery, Chinese People's Liberation Army General Hospital was collected. After propensity score matching, 70 patients in robotic gastectomy and 70 patients in laparoscopic gastectomy were identified. Perioperative outcome and overall survival were compared between the two groups using t test, χ(2) test, Kaplan-Meier curve and Log-rank test, respectively...
January 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29322340/the-use-of-a-smartphone-assisted-ventricle-catheter-guide-for-ommaya-reservoir-placement-experience-of-a-retrospective-bi-center-study
#2
Sergey Ozerov, U W Thomale, M Schulz, A Schaumann, A Samarin, E Kumirova
BACKGROUND: For intraventricular chemotherapy (IVC) as part of many oncological treatment protocols, Ommaya reservoir is enabling repeated access to the cerebro-spinal fluid (CSF). The correct placement of the catheter in the ventricle is essential for correct application of drugs, which is enabled by sophisticated techniques such as neuronavigation. OBJECTIVE: In a bi-center retrospective study, we reviewed our experience using a smartphone-assisted ventricle catheter guide as simple solution for correct Ommaya reservoir placement...
January 10, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29319482/perioperative-chemotherapy-for-bladder-cancer-a-qualitative-study-of-physician-knowledge-attitudes-and-behaviour
#3
Melanie Walker, R Christopher Doiron, Simon D French, Deb Feldman-Stewart, D Robert Siemens, William J Mackillop, Christopher M Booth
INTRODUCTION: Use of chemotherapy for muscle-invasive bladder cancer (MIBC) is known to be low. To understand factors driving practice we use the Theoretical Domains Framework (TDF) to identify barriers and enablers of chemotherapy use. METHODS: A convenience sample of Canadian urologists, medical oncologists (MOs) and radiation oncologists (ROs) participated in individual, semi-structured, one-hour telephone interviews. An interview guide was developed using the TDF to assess potential barriers and enablers of chemotherapy use...
December 22, 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29319236/neoadjuvant-chemotherapy-followed-by-minimally-invasive-esophagectomy-is-safe-and-feasible-for-treatment-of-esophageal-squamous-cell-carcinoma
#4
Shaohua Ma, Tiansheng Yan, Dandan Liu, Keyi Wang, Jingdi Wang, Jintao Song, Tong Wang, Wei He, Jie Bai, Liang Jin, Xiaoxin Chen
BACKGROUND: The advantage of neoadjuvant chemotherapy (NAC) followed by open esophagectomy for treatment of esophageal squamous cell carcinoma has been widely recognized. However, the safety and feasibility of NAC for patients receiving minimally invasive esophagectomy (MIE) remain controversial. The purpose of this study was to evaluate the potential impact of prior neoadjuvant chemotherapy on the clinical outcome of MIE by comparing two groups of patients, MIE alone and NAC plus MIE...
January 10, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29308374/alcohol-devitalization-and-replantation-for-primary-malignant-bone-tumors-of-the-knee-joint
#5
Xihai Zhang, Ge Chen, Jun Wang, Lian Tang, Yiran Yin
Background: This paper is aimed at studying the therapeutic effects of in situ replantation of alcohol-devitalized bone segments to treat malignant bone tumors of the knee joint. Methods: We retrospectively analyzed clinical data for 45 patients from January 2013 to January 2016 who underwent replantation following alcohol-devitalization of bone segments and 40 who underwent prosthesis implantation. The two groups were comparable in basal clinical biometric data, including gender, age, tumor type and location, Enneking staging, and maximum tumor diameter...
October 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/29302727/implications-of-stoma-formation-as-part-of-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy
#6
H Jacoby, Y Berger, L Barda, N Sharif, Y Zager, A Lebedyev, M Gutman, A Hoffman
BACKGROUND: Formation of protective stoma as part of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) may be an effective tool in reducing anastomotic leak incidence. Our aim was to evaluate the incidence and implications of stoma formation during CRS-HIPEC and to examine whether a creation of protective stoma reduces the postoperative morbidity. METHODS: A cohort retrospective analysis of all CRS-HIPEC procedures performed between 2004 and 2016 was conducted...
January 4, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29299362/tumor-response-evaluation-after-neoadjuvant-chemotherapy-in-locally-advanced-gastric-adenocarcinoma-a-prospective-multi-center-cohort-study
#7
Pietro Achilli, Paolo De Martini, Marco Ceresoli, Giulio M Mari, Andrea Costanzi, Dario Maggioni, Raffaele Pugliese, Giovanni Ferrari
Background: To verify the prognostic value of the pathologic and radiological tumor response after neoadjuvant chemotherapy in the treatment of locally advanced gastric adenocarcinoma. Methods: A total of 67 patients with locally advanced gastric cancer (clinical ≥ T2 or nodal disease and without evidence of distant metastases) underwent perioperative chemotherapy (ECF or ECX regimen) from December 2009 through June 2015 in two surgical units. Histopathological and radiological response to chemotherapy were evaluated by using tumor regression grade (TRG) (Becker's criteria) and volume change assessed by CT...
December 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29288614/laparoscopic-hipec-for-peritoneal-carcinomatosis-from-gastric-cancer-technique-and-early-outcomes-of-our-first-cases
#8
Irina Bălescu, Daniela Godoroja, Mircea Gongu, Victor Tomulescu, Cătălin Copăescu
Gastric cancer remains one of the most aggressive malignancies, being associated with very poor therapeutic outcomes, especially in the advanced disease patients. Due to this evidence, finding a better treatment, a better control and higher survival rates is the current scientific focus of the medical community. Once the benefits of cytoreductive surgery in association with intraperitoneal hyperthermy (HIPEC) have been widely demonstrated in patients presenting peritoneal carcinomatosis from colorectal or ovarian origin,attention was focused on the possible benefit of this method in patients diagnosed with peritoneal carcinomatosis with gastric origin...
November 2017: Chirurgia
https://www.readbyqxmd.com/read/29285376/neoadjuvant-treatment-with-cisplatin-and-s-1-in-elderly-patients-with-oesophagogastric-adenocarcinoma-and-locoregional-disease-two-case-reports-and-review-of-the-literature
#9
Caspar Franck, Ali Canbay, Peter Malfertheiner, Marino Venerito
Perioperative platinum/fluoropyrimidine-based chemotherapy is the therapeutic standard for oesophagogastric cancer (OAC) patients with locoregional disease. The preoperative condition directly affects postoperative prognosis; thus, particularly for elderly patients, a perioperative regimen with a favourable side effect profile is highly desirable. In the palliative setting, the combination of cisplatin and S-1 (Cis/S-1) was found to be as effective as cisplatin/5-fluorouracil, but with a more favourable side effect profile...
December 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29281852/evolution-of-cystectomy-care-over-a-11-years-period-in-a-high-volume-tertiary-referral-center
#10
Aldo Brassetti, Axel Möller, Oscar Laurin, Jonas Höijer, Christofer Adding, Ayako Miyakawa, Abolfazl Hosseini, Peter Wiklund
OBJECTIVES: To describe the evolution RC care over 11 years in a referral center. MATERIALS AND METHODS: Clinical data of patients undergoing either open RC (ORC) or robot-assisted RC (RARC) for cT1-4aN0M0 bladder cancer (BCa) at our center between 01/2006 and 12/2016 were retrospectively evaluated. Crude and propensity score weighted log-binomial regression analyses assessed the association between pre-/perioperative variables and the risk of reoperation, intensive care unit (ICU) admission and death within 90 days after RC...
December 27, 2017: BJU International
https://www.readbyqxmd.com/read/29277807/cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-in-elderly-patients-complete-cytoreduction-is-feasible-and-crucial-for-improved-survival-despite-high-carcinomatosis-index
#11
Samer A Naffouje, George I Salti
BACKGROUND: We aimed to study the surgical outcomes of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in elderly patients, and investigate whether the pursuit of complete cytoreduction implies a survival benefit despite a high peritoneal carcinomatosis index (PCI). PATIENTS AND METHODS: All CRS and HIPEC procedures performed for patients with peritoneal surface malignancy (PSM) ≥65 years old between 2005-2017 were included. A control group comprising patients 60-64 years old who underwent CRS and HIPEC over the same period was also selected for comparison of characteristics and outcomes...
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29260635/comparison-of-two-indices-to-annotate-complications-after-radical-nephroureterectomy
#12
Rosa Park, Christopher Rjepaj, Kathleen Lehman, Jay D Raman
INTRODUCTION: The Clavien-Dindo (CD) and Comprehensive Complication Index (CCI) are two grading systems that annotate adverse events following surgical procedures. We compare these two classification systems in a cohort of patients undergoing radical nephroureterectomy (RNU). MATERIALS AND METHODS: The charts of 110 consecutive RNU patients were reviewed for complications occurring within 30 days of surgery. Grading by the CD classification system and values for CCI were calculated...
December 2017: Canadian Journal of Urology
https://www.readbyqxmd.com/read/29260244/-the-use-of-tumor-therapeutics-in-the-perioperative-period
#13
REVIEW
V Luber, J Wagner, J F Lock, U A Dietz, S Lichthardt, N Matthes, K Krajinovic, C-T Germer, A Wiegering, S Knop
In 2010 Germany had 447,300 new cases of cancer. From 2000 to 2010 the incidence of cancer increased by 21% in men and by 14% in women. The change in the age structure with an aging population is the crucial influencing factor. Various cancer types can now be treated by oral antitumor agents used as a chronic medication. Physicians must decide whether the oral antitumor agents can be continued perioperatively or if certain drugs must be paused and if so, with what risks. Oral antitumor agents are a very heterogeneous group of medication...
December 19, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29258674/surgical-outcomes-after-neoadjuvant-chemotherapy-and-ipilimumab-for-non-small-cell-lung-cancer
#14
Chi-Fu Jeffrey Yang, Frances McSherry, Nicholas R Mayne, Xiaofei Wang, Mark F Berry, Betty Tong, David H Harpole, Thomas A D'Amico, Jared D Christensen, Neal E Ready, Jacob A Klapper
BACKGROUND: The objective of this study was to evaluate the safety and feasibility of using neoadjuvant chemotherapy plus ipilimumab followed by surgery as a treatment strategy for stage II-IIIA non-small-cell lung cancer. METHODS: From 2013 to 2017, postoperative data from patients who underwent surgery after neoadjuvant chemotherapy plus ipilimumab in the TOP1201 trial, an open label phase II trial (NCT01820754), were prospectively collected. The surgical outcomes from TOP1201 were compared with outcomes in a historical cohort of patients receiving standard preoperative chemotherapy followed by surgery identified from our institution's prospectively collected thoracic surgery database...
December 16, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29249869/short-term-postoperative-cognitive-dysfunction-and-inflammatory-response-in-patients-undergoing-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-a-pilot-study
#15
Hui Yu, Rui Dong, Yayuan Lu, Xi Yang, Chang Chen, Zongze Zhang, Mian Peng
Objectives: To assess the association between short-term postoperative cognitive dysfuction (POCD) and inflammtory response in patients undergoing cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Design: A prospective cohort study. Setting: University medical centre. Participants: Fifty-one adult patients who had undergone CRS-HIPEC and twenty control participants. Measurements: The inflammatory marker levels in plasma and cognitive function were measured...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/29248381/high-grade-thalamic-gliomas-microsurgical-treatment-and-prognosis-analysis
#16
Biwu Wu, Chao Tang, Yang Wang, Zhiqi Li, Shukun Hu, Wei Hua, Wengang Li, Shan Huang, Junfeng Ma, Yi Zhang
This retrospective study is aimed to investigate the efficacy of microsurgical treatment for high-grade thalamic gliomas, and to analyze the relevant prognosis. From May 2011 to Aug 2015, 49 patients with thalamic gliomas underwent microsurgical resection, and received chemotherapy and radiotherapy postoperatively. The postoperative symptoms and complications were documented, and the overall survival (OS) and the progression-free survival (PFS) data were collected. The prognostic factors were evaluated by univariate and multivariate analyses...
December 13, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29242018/current-practice-in-cytoreductive-surgery-and-hipec-for-metastatic-peritoneal-disease-spanish-multicentric-survey
#17
Rafael Morales-Soriano, Neus Esteve-Pérez, Juan José Segura-Sampedro, Pedro Cascales-Campos, Pedro Barrios
INTRODUCTION: Radical Cytoreductive Surgery (CRS) with Hyperthermic Intraperitoneal Chemotherapy (HIPEC), has been proposed as the current standard of treatment for metastatic peritoneal disease by several tumors. Despite its widely utilization, there seems to be a great variability in their organization, clinical practice, and safety among centers. AIM OF THE STUDY: To obtain updated information on clinical practice in different perioperative areas of the CRS-HIPEC...
December 6, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29241177/surgical-management-of-recurrent-intracranial-gliomas
#18
Sherise D Ferguson, Eric N Momin, Jeffrey S Weinberg
In cases of recurrent gliomas, the treatment options are limited and not yet standardized. Choices usually include re-operation, systemic chemotherapy, salvage re-irradiation, and supportive care, which can be used either separately or in combination. From a surgical perspective, management of recurrent brain tumor poses a significant challenge, as the desire to attain aggressive lesion resection must be balanced against the need to preserve neurological functions and to maximize the quality of life. Additionally, specific practical difficulties in performing repeat craniotomies and significant risk of perioperative morbidity in such cases necessitate careful selection of the optimal candidates for surgery...
2018: Progress in Neurological Surgery
https://www.readbyqxmd.com/read/29224818/reconstruction-after-salvage-laryngectomy
#19
David H Yeh, Axel Sahovaler, Kevin Fung
Both early and advanced stage laryngeal cancers are treated with organ-preserving strategies including radiation alone or concurrent chemoradiotherapy. While organ-preserving modalities have proven effective in eradicating cancer while also preserving laryngeal function, there remains a proportion of cases where residual or recurrent cancer prevails, or conversely, where radiotherapy renders a larynx dysfunctional. In these circumstances, salvage total laryngectomy is often the surgical treatment. The effects of radiotherapy to the neck, amplified by chemotherapy, can create an inhospitable surgical environment, making the salvage laryngectomy an operation fraught with the potential for major complications such as the dreaded pharyngocutaneous fistula...
December 2017: Oral Oncology
https://www.readbyqxmd.com/read/29220299/perioperative-management-of-extremity-soft-tissue-sarcomas
#20
Rick L Haas, Alessandro Gronchi, Michiel A J van de Sande, Elizabeth H Baldini, Hans Gelderblom, Christina Messiou, Eva Wardelmann, Axel Le Cesne
Surgery is potentially curative for primary nonmetastatic extremity soft tissue sarcomas. After surgery alone, patients may remain at risk for local recurrences and/or metastatic disease. To reduce the likelihood of a local relapse, the addition of radiotherapy (RT) to limb-sparing surgery may result in higher local control rates of at least 85%. Generally, it can be stated that local control after both preoperative and postoperative RT is comparable, but that preoperative RT comes with a more favorable toxicity profile after prolonged follow-up, albeit at the cost of a higher wound complication rate...
December 8, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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