keyword
https://read.qxmd.com/read/38457547/compound-heterozygosity-for-southeast-asian-hereditary-persistence-of-fetal-hemoglobin-and-%C3%AE-0-thalassemia-results-in-thalassemia-intermedia-pedigree-analysis-and-genetic-research-in-a-family-from-south-china-a-case-report
#21
JOURNAL ARTICLE
Guangli Wang, Huiping Deng, Peng Peng, Haiqing Zheng, Baodong Tian, Chunjiang Zhu
RATIONALE: Compound heterozygotes for deletional β-thalassemia can be difficult to diagnose due to its diverse clinical presentations and no routine screenings. This can lead to disease progression and delay in treatment. PATIENT CONCERNS: We reported pedigree analysis and genetic research in a family with rare β-thalassemia. DIAGNOSIS: Pedigree analysis and genetic research demonstrated that the patient was a compound heterozygote for β-thalassemia CD17/Southeast Asian hereditary persistence of fetal hemoglobin deletion, inherited from the parents...
March 8, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38454409/rna-seq-analysis-of-chlorogenic-acid-intervention-in-duck-embryo-fibroblasts-infected-with-duck-plague-virus
#22
JOURNAL ARTICLE
Yunyun Yang, Qiandong Zhang, Haiqing Cai, Yi Feng, Anlin Wen, Ying Yang, Ming Wen
INTRODUCTION: Chlorogenic acid, the primary active component in Chinese medicines like honeysuckle, exhibits anti-inflammatory and antiviral effects. It has been demonstrated that chlorogenic acid effectively prevents and treats Duck enteritis virus (DEV) infection. This study aims to further elucidate the mechanism by which chlorogenic acid prevents DEV infection. METHODS: Duck embryo fibroblast (DEF) cells were pre-treated with chlorogenic acid before being infected with DEV...
March 7, 2024: Virology Journal
https://read.qxmd.com/read/38450906/precision-unveiled-synergistic-genomic-landscapes-in-breast-cancer-integrating-single-cell-analysis-and-decoding-drug-toxicity-for-elite-prognostication-and-tailored-therapeutics
#23
JOURNAL ARTICLE
Chenglu Jiang, Shengke Zhang, Lai Jiang, Zipei Chen, Haiqing Chen, Jinbang Huang, Jingyi Tang, Xiufang Luo, Guanhu Yang, Jie Liu, Hao Chi
BACKGROUND: Globally, breast cancer, with diverse subtypes and prognoses, necessitates tailored therapies for enhanced survival rates. A key focus is glutamine metabolism, governed by select genes. This study explored genes associated with T cells and linked them to glutamine metabolism to construct a prognostic staging index for breast cancer patients for more precise medical treatment. METHODS: Two frameworks, T-cell related genes (TRG) and glutamine metabolism (GM), stratified breast cancer patients...
March 7, 2024: Environmental Toxicology
https://read.qxmd.com/read/38449635/a-reliable-evaluation-approach-for-multichannel-signal-denoising-algorithms-based-on-a-novel-arterial-pulse-acquisition-system
#24
JOURNAL ARTICLE
Chao Chen, Zhendong Chen, Yuqi Zhou, Yinan Hao, Bo Peng, Xiaohua Xie, Haiqing Xie
BACKGROUND: Tactile sensors are utilized to measure multichannel pulse signals in pulse wave analysis (PWA). Owing to noise interferences, researchers have applied various denoising algorithms on multichannel pulse signals. To comprehensively assess these algorithms, numerous evaluation metrics have been proposed. However, these studies did not investigate the noise mechanisms in depth and lacked reference pulse signals, thus making the evaluations insufficiently objective. MATERIALS AND METHODS: An applicable denoising evaluation approach for multichannel pulse signal algorithms based on an arterial pulse acquisition system is established by superimposing real-world multichannel noise to the reference signals...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38447242/study-on-material-basis-and-anti-hypertensive-metabolomics-of-zhengan-xifeng-tang-zxt-a-comparison-between-zxt-decoction-and-granules
#25
JOURNAL ARTICLE
Haichao Li, Lihua Wang, Hao Zhang, Wenchi Yu, Yunlun Li, Haiqing Jiang, Danyang Wang, Yu Wang
High blood pressure is a serious human health problem and one of the leading risk factors for fatal complications in cardiovascular disease. The ZXT granules were prepared based on the Zhengan-Xifeng-Tang (ZXT) decoction. However, the therapeutic effects of ZXT granules on spontaneous hypertension and the metabolic pathways in which they may intervene are unclear. The aim of this study was to investigate the antihypertensive effect of ZXT granules on spontaneously hypertensive rats (SHR) and to analyze the metabolic pathway of intervention through chemical composition characterization, pharmacodynamics, and serum metabolomics analysis...
March 1, 2024: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://read.qxmd.com/read/38433762/high-krt17-expression-in-tumour-budding-indicates-immunologically-hot-tumour-budding-and-predicts-good-survival-in-patients-with-colorectal-cancer
#26
JOURNAL ARTICLE
Wenfeng Liang, Haiqing Jie, Hao Xie, Yebohao Zhou, Wenxin Li, Liang Huang, Zhenxing Liang, Huashan Liu, Xiaobin Zheng, Ziwei Zeng, Liang Kang
OBJECTIVES: Emerging evidence has demonstrated that tumour budding (TB) is negatively associated with T-lymphocyte infiltration in CRC. Despite extensive research, the molecular characteristics of immunologically 'hot' TB remain poorly understood. METHODS: We quantified the number of TB by haematoxylin-eosin (H&E) sections and the densities of CD3+ and CD8+ T-lymphocytes by immunohistochemistry in a CRC cohort of 351 cases who underwent curative resection. We analysed the differential expression and T-lymphocyte infiltration score of 37 human epithelial keratins in CRC using RNA sequencing from the TCGA dataset...
2024: Clinical & Translational Immunology
https://read.qxmd.com/read/38433494/the-thalamic-covariance-network-is-associated-with-cognitive-deficits-in-patients-with-cerebral-small-vascular-disease
#27
JOURNAL ARTICLE
Wei Yan, Siwei Tang, Li Chen, Ting Lei, Haiqing Li, Yuxing Jiang, Miao He, Lijing Zhou, Yajun Li, Chen Zeng, Hongjian Li
OBJECTIVE: Abnormalities in the gray matter structure of cerebral small vessel disease (CSVD) have been observed throughout the brain. However, whether cortico-cortical connections exist between regions of gray matter atrophy in patients with CSVD has not been fully elucidated. This question was tested by comparing the gray matter covariance networks in CSVD patients with and without cognitive impairment (CI). METHODS: We performed multivariate modeling of the gray matter volume measurements of 61 patients with CI (CSVD-CI), 85 patients without CI (CSVD-NC), and 108 healthy controls using source-based morphological analysis (SBM) to obtain gray matter structural covariance networks at the population level...
March 3, 2024: Annals of Clinical and Translational Neurology
https://read.qxmd.com/read/38432464/assessment-of-occurrence-partitioning-and-ecological-risk-for-144-steroid-hormones-in-taihu-lake-using-uplc-ms-ms-with-machine-learning-model
#28
JOURNAL ARTICLE
Li Zhao, Chao Wang, Fuhong Sun, Haiqing Liao, Hong Chang, Xudong Jia
Steroid hormones (SHs) have attracted mounting attention due to their endocrine-disrupting effects on humans and aquatic organisms. However, the lack of analytical methods and toxicity data for a large number of SHs has limited the effective management of SH contamination in the water-sediment systems. In this study, we developed a highly sensitive analytical method for the simultaneous quantification of 144 SHs to investigate their occurrence, spatial distribution and partitioning in the water and sediment in Taihu Lake...
March 1, 2024: Chemosphere
https://read.qxmd.com/read/38428235/feasibility-of-replacing-proton-exchange-membranes-with-pressure-driven-membranes-in-membrane-electrochemical-reactors-for-high-salinity-organic-wastewater-treatment
#29
JOURNAL ARTICLE
Zhongsen Yan, Xiaolei Chen, Haiqing Chang, Heliang Pang, Gongduan Fan, Kaiqin Xu, Heng Liang, Fangshu Qu
Membrane electrochemical reactor (MER) shows superiority to electrochemical oxidation (EO) in high salinity organic wastewater (HSOW) treatment, but requirement of proton exchange membranes (PEM) increases investment and maintenance cost. In this work, the feasibility of using low-cost pressure-driven membranes as the separation membrane in MER system was systematically investigated. Commonly used pressure-driven membranes, including loose membranes such as microfiltration (MF) and ultrafiltration (UF), as well as dense membranes like nanofiltration (NF) and reverse osmosis (RO), were employed in the study...
February 19, 2024: Water Research
https://read.qxmd.com/read/38425993/increasing-the-sensor-channels-a-solution-for-the-pressing-offsets-that-cause-the-physiological-parameter-inaccuracy-in-radial-artery-pulse-signal-acquisition
#30
JOURNAL ARTICLE
Chao Chen, Zhendong Chen, Hongmiin Luo, Bo Peng, Yinan Hao, Xiaohua Xie, Haiqing Xie, Xinxin Li
Introduction: In studies of pulse wave analysis, single-channel sensors only adopt single temporal pulse signals without spatial information to show pulse-feeling patterns. Multi-channel arterial pulse signals, also named as three-dimensional pulse images (3DPIs), provide the spatial and temporal characteristics of radial pulse signals. When involving single or few-channel sensors, pressing offsets have substantial impacts on obtaining inaccurate physiological parameters like tidal peak (P2 ). Methods: This study discovers the pressing offsets in multi-channel pulse signals and analyzes the relationship between the pressing offsets and time of P2 (T2 ) by qualifying the pressing offsets...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38421433/analyzing-microbial-community-and-volatile-compound-profiles-in-the-fermentation-of-cigar-tobacco-leaves
#31
JOURNAL ARTICLE
Mingzhu Zhang, Dongfeng Guo, Haiqing Wang, Guanglong Wu, Yaqi Shi, Jinlong Zhou, Eryong Zhao, Tianfei Zheng, Xingjiang Li
Variations in industrial fermentation techniques have a significant impact on the fermentation of cigar tobacco leaves (CTLs), consequently influencing the aromatic attributes of the resulting cigars. The entire fermentation process of CTLs can be categorized into three distinct phases: phase 1 (CTLs prior to moisture regain), phase 2 (CTLs post-moisture regain and pile fermentation), and phase 3 (CTLs after fermentation and drying). These phases were determined based on the dynamic changes in microbial community diversity...
February 29, 2024: Applied Microbiology and Biotechnology
https://read.qxmd.com/read/38411318/immunogenicity-of-avelumab-in-patients-with-metastatic-merkel-cell-carcinoma-or-advanced-urothelial-carcinoma
#32
JOURNAL ARTICLE
Ping Hu, Haiqing Isaac Dai, James Bourdage, Dongli Zhou, Ky Trang, Karey Kowalski, Carlo Bello, Jennifer Hibma, Akash Khandelwal, Kyra Cowan, Jennifer Dong, Karthik Venkatakrishnan, Wei Gao
Like other monoclonal antibodies, immune checkpoint inhibitors may be immunogenic in some patients, potentially affecting pharmacokinetics (PKs) and clinical outcomes. In post hoc analyses, we characterized antidrug antibody (ADA) development with avelumab monotherapy in patients with metastatic Merkel cell carcinoma (mMCC) from the JAVELIN Merkel 200 trial (first-line [1L; N = 116] and second-line or later [≥2L; N = 88] cohorts) or with advanced urothelial carcinoma (aUC) from the JAVELIN Bladder 100 (1L maintenance [N = 350]) and JAVELIN Solid Tumor (≥2L [N = 249]) trials...
March 2024: Clinical and Translational Science
https://read.qxmd.com/read/38407656/correlation-study-on-microbial-communities-and-volatile-flavor-compounds-in-cigar-tobacco-leaves-of-diverse-origins
#33
JOURNAL ARTICLE
Haiqing Wang, Dongfeng Guo, Mingzhu Zhang, Guanglong Wu, Yaqi Shi, Jinglong Zhou, Naihong Ding, Xiangsong Chen, Xingjiang Li
To elucidate the significant influence of microorganisms on geographically dependent flavor formation by analyzing microbial communities and volatile flavor compounds (VFCs) in cigar tobacco leaves (CTLs) obtained from China, Dominica, and Indonesia. Microbiome analysis revealed that the predominant bacteria in CTLs were Staphylococcus, Aerococcus, Pseudomonas, and Lactobacillus, while the predominant fungi were Aspergillus, Wallemia, and Sampaiozyma. The microbial communities of CTLs from different origins differed to some extent, and the diversity and abundance of bacteria were greater than fungi...
February 26, 2024: Applied Microbiology and Biotechnology
https://read.qxmd.com/read/38406194/detection-of-dynamic-changes-of-electrodermal-activity-to-predict-the-classroom-performance-of-college-students
#34
JOURNAL ARTICLE
Haiqing Yu, Minpeng Xu, Xiaolin Xiao, Fangzhou Xu, Dong Ming
It is emphasized in the Self-regulated learning (SRL) framework that self-monitoring of learning state is vital for students to keep effective in studying. However, it's still challenging to get an accurate and timely understanding of their learning states during classes. In this study, we propose to use electrodermal activity (EDA) signals which are deemed to be associated with physiological arousal state to predict the college student's classroom performance. Twenty college students were recruited to attend eight lectures in the classroom, during which their EDA signals were recorded simultaneously...
February 2024: Cognitive Neurodynamics
https://read.qxmd.com/read/38404067/cohering-plasma-into-adhesive-gel-by-natural-biopolymer-nanoparticle-hybrid-powder-for-efficient-hemostasis-and-wound-healing
#35
JOURNAL ARTICLE
Yan Fang, Yukai Lin, Linyu Wang, Qinhui Chen, Yunxiang Weng, Caixia Sun, Haiqing Liu
Hemostatic powder is commonly used in emergency bleeding control due to its suitability for irregularly shaped wounds, ease of use, and stable storage. However, traditional powder often has limited tissue adhesion and weak thrombus support, which makes it vulnerable to displacement by blood flow. Herein, we have developed a tricomponent hemostatic powder (MQS) composed of mesoporous bioactive glass nanoparticle (MBG), positively charged quaternized chitosan (QCS), and negatively charged catechol-modified alginate (SADA)...
February 25, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38395457/association-of-non-obstructive-dyspnoea-with-all-cause-mortality-and-incident-chronic-obstructive-pulmonary-disease-a-systematic-literature-review-and-meta-analysis
#36
JOURNAL ARTICLE
Yuyan Hou, Fan Wu, Huanhuan Fan, Haiqing Li, Binwei Hao, Zhishan Deng, Xiaoyan Lu, Yumin Zhou, Pixin Ran
BACKGROUND: Controversy exists regarding the association between non-obstructive dyspnoea and the future development of chronic obstructive pulmonary disease (COPD) and mortality. Therefore, we aimed to evaluate the association of non-obstructive dyspnoea with mortality and incident COPD in adults. METHODS: We searched PubMed, Embase, and Web of Science to identify studies published from inception to 13 May 2023. Eligibility screening, data extraction, and quality assessment of the retrieved articles were conducted independently by two reviewers...
February 23, 2024: BMJ Open Respiratory Research
https://read.qxmd.com/read/38392657/membrane-separation-technology-in-direct-air-capture
#37
REVIEW
Pavlo Ignatusha, Haiqing Lin, Noe Kapuscinsky, Ludmila Scoles, Weiguo Ma, Bussaraporn Patarachao, Naiying Du
Direct air capture (DAC) is an emerging negative CO2 emission technology that aims to introduce a feasible method for CO2 capture from the atmosphere. Unlike carbon capture from point sources, which deals with flue gas at high CO2 concentrations, carbon capture directly from the atmosphere has proved difficult due to the low CO2 concentration in ambient air. Current DAC technologies mainly consider sorbent-based systems; however, membrane technology can be considered a promising DAC approach since it provides several advantages, e...
January 24, 2024: Membranes
https://read.qxmd.com/read/38390161/night-shift-work-was-associated-with-functional-outcomes-in-acute-ischemic-stroke-patients-treated-with-endovascular-thrombectomy
#38
JOURNAL ARTICLE
Wantong Yu, Jin Ma, Wenting Guo, Jiali Xu, Jun Xu, Sijie Li, Changhong Ren, Longfei Wu, Chuanjie Wu, Chuanhui Li, Jian Chen, Jiangang Duan, Qingfeng Ma, Haiqing Song, Wenbo Zhao, Xunming Ji
OBJECTIVE: This study aimed to explore the impact of late night shift work on the functional outcomes of patients with acute ischemic stroke (AIS) treated with endovascular thrombectomy (EVT). METHODS: Consecutive AIS patients who underwent EVT between June 2019 and June 2021 were enrolled and divided into non-night shift work and night shift work groups based on their occupational histories. The primary outcome was the modified Rankin Scale score defined 3-month functional outcome...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38377550/integrating-network-pharmacology-and-experimental-validation-to-reveal-the-mechanism-of-vine-grape-tea-polyphenols-on-hyperuricemia-induced-renal-injury-in-mice
#39
JOURNAL ARTICLE
Xiaoli Li, Baoying Li, Xinyue Meng, Fei Yu, Xin Yu, Wenqian Zhao, Yajuan Wang, Haiqing Gao, Mei Cheng, Lihong Zhong
Hyperuricemia (HUA) is a metabolic disease and contributes to renal injury (RI). Vine grape tea polyphenols (VGTP) have been widely used to treat HUA and RI. However, the potential mechanism of VGTP activity remains unclear. To explore the underlying mechanism of VGTP treatment for HUA-induced RI based on network pharmacology that is confirmed by an in vivo study. All ingredients of VGTP were retrieved using a Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform and Comparative Toxicogenomics Database systems...
February 19, 2024: Journal of Medicinal Food
https://read.qxmd.com/read/38372265/low-loading-mixed-matrix-materials-fractal-like-structure-and-peculiarly-enhanced-gas-permeability
#40
JOURNAL ARTICLE
Taliehsadat Alebrahim, Liang Huang, Heshali K Welgama, Narjes Esmaeili, Erda Deng, Shiwang Cheng, Durga Acharya, Cara M Doherty, Anita J Hill, Clayton Rumsey, Martin Trebbin, Timothy R Cook, Haiqing Lin
Mixed matrix materials (MMMs) containing metal-organic framework (MOF) nanoparticles are attractive for membrane carbon capture. Particularly, adding <5 mass % MOFs in polymers dramatically increased gas permeability, far surpassing the Maxwell model's prediction. However, no sound mechanisms have been offered to explain this unusual low-loading phenomenon. Herein, we design an ideal series of MMMs containing polyethers (one of the leading polymers for CO2 /N2 separation) and discrete metal-organic polyhedra (MOPs) with cage sizes of 2-5 nm...
February 19, 2024: ACS Applied Materials & Interfaces
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