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https://www.readbyqxmd.com/read/28549174/phosphorylated-sirt1-associates-with-replication-origins-to-prevent-excess-replication-initiation-and-preserve-genomic-stability
#1
Koichi Utani, Haiqing Fu, Sang-Min Jang, Anna B Marks, Owen K Smith, Ya Zhang, Christophe E Redon, Noriaki Shimizu, Mirit I Aladjem
Chromatin structure affects DNA replication patterns, but the role of specific chromatin modifiers in regulating the replication process is yet unclear. We report that phosphorylation of the human SIRT1 deacetylase on Threonine 530 (T530-pSIRT1) modulates DNA synthesis. T530-pSIRT1 associates with replication origins and inhibits replication from a group of 'dormant' potential replication origins, which initiate replication only when cells are subject to replication stress. Although both active and dormant origins bind T530-pSIRT1, active origins are distinguished from dormant origins by their unique association with an open chromatin mark, histone H3 methylated on lysine 4...
May 26, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28539214/validation-of-the-eighth-edition-of-the-tnm-staging-system-for-lung-cancer-in-2043-surgically-treated-patients-with-non-small-cell-lung-cancer
#2
Kezhong Chen, Haiqing Chen, Fan Yang, Xizhao Sui, Xiao Li, Jun Wang
PURPOSE: The International Association for the Study of Lung Cancer has proposed a revision of the Tumor, Node, Metastasis (TNM) classification for lung cancer. The purpose of this study is to evaluate the prognostic value of the eighth edition of the TNM staging system in surgically treated patients with non-small-cell lung cancer. METHODS: Data from 2043 consecutive patients with non-small-cell lung cancer who underwent surgical treatment in our single center between January 2006 and September 2015 were collected and analyzed retrospectively...
April 12, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28537755/a-pilot-study-of-noninvasive-prenatal-diagnosis-of-alpha-and-beta-thalassemia-with-target-capture-sequencing-of-cell-free-fetal-dna-in-maternal-blood
#3
Wenjuan Wang, Yuan Yuan, Haiqing Zheng, Yaoshen Wang, Dan Zeng, Yihua Yang, Xin Yi, Yang Xia, Chunjiang Zhu
AIMS: Thalassemia is a dangerous hematolytic genetic disease. In south China, ∼24% Chinese carry alpha-thalassemia or beta-thalassemia gene mutations. Given the fact that the invasive sampling procedures can only be performed by professionals in experienced centers, it may increase the risk of miscarriage or infection. Thus, most people are worried about the invasive operation. As such, a noninvasive and accurate prenatal diagnosis is needed for appropriate genetic counseling for families with high risks...
May 24, 2017: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/28532047/porous-chitosan-microspheres-for-application-as-quick-in-vitro-and-in-vivo-hemostat
#4
Jixiang Li, Xiaowei Wu, Yanqing Wu, Zonghao Tang, Xun Sun, Meng Pan, Yufeng Chen, Juanjuan Li, Rongdong Xiao, Zhengchao Wang, Haiqing Liu
Controlling massive hemorrhage is of great importance to lower transfusional medical cost, and to reduce death and mobility rate in battlefield and civilian accidents. We reported the fabrication of porous chitosan microspheres (CSMS) with tunable surface pore size by microemulsion combined with thermally induced phase separation technique, and its application as a quick hemostat. Their hemostatic property was characterized by blood clotting kinetics, adherence interaction between red blood cells/platelets and CSMS, in vitro and in vivo hemostasis by rat tail amputation and liver laceration models, and histological analysis...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28523165/plasma-levels-of-matrix-metalloproteinase-9-in-patients-undergoing-off-pump-coronary-artery-bypass-grafting
#5
Haiqing Li, Zhize Yuan, Sen Li, Quan Qi, Jun Liu, Mi Zhou, Junfeng Cai, Anqing Chen, Zhe Wang, Xiaofeng Ye, Qiang Zhao
BACKGROUND: Matrix metalloproteinase 9 (MMP9) has recently emerged as a risk predictor in patients with cardiovascular diseases. However, little is known about the significance of increased plasma MMP9 in patients with perioperative myocardial injury. We aimed to investigate the role of MMP9 in the occurrence of myocardial injury during off-pump coronary artery bypass grafting (OPCAB). METHODS: A total of 34 consecutive patients with coronary artery diseases (CAD) were recruited in this prospective, observational study...
April 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28523159/nomograms-for-predicting-recurrence-and-survival-of-invasive-pathological-stage-ia-non-small-cell-lung-cancer-treated-by-video-assisted-thoracoscopic-surgery-lobectomy
#6
Haiqing Chen, Xizhao Sui, Fan Yang, Jun Liu, Jun Wang
BACKGROUND: A considerable portion of pathological stage (p-stage) IA non-small cell lung cancer (NSCLC) patients suffered from death and recurrence after video assisted thoracoscopic surgery (VATS) lobectomy. The purpose of our study was to develop nomograms to predict which subgroup patients were more likely to suffer from recurrence or death. METHODS: Data of invasive p-stage IA NSCLC patients who underwent VATS lobectomy at Peking University People's Hospital from September 2006 to April 2014 were analyzed...
April 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28521633/cd30-expression-in-pediatric-neoplasms-study-of-585-cases
#7
Jinjun Cheng, Haiqing Zhu, John Kim Choi
CD30 is a member of the tumor necrosis factor receptor superfamily, member 8 (TNFRSF8), and its normal expression is restricted to activated T and B cells. In tumor cells, CD30 expression is most commonly associated with lymphoid malignancies (Hodgkin and non-Hodgkin lymphomas) and is a therapeutic target using anti-CD30 antibody. CD30 expression has been reported also in mostly adult non-lymphoid malignancies, raising the possibility of CD30-targeted therapy for additional tumors. In this study, we examined the incidence of CD30 expression in 251 hematopoietic and 334 non-hematopoietic cases of pediatric tumors...
June 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28507120/highly-active-catalyst-derived-from-a-3d-foam-of-fe-po3-2-ni2p-for-extremely-efficient-water-oxidation
#8
Haiqing Zhou, Fang Yu, Jingying Sun, Ran He, Shuo Chen, Ching-Wu Chu, Zhifeng Ren
Commercial hydrogen production by electrocatalytic water splitting will benefit from the realization of more efficient and less expensive catalysts compared with noble metal catalysts, especially for the oxygen evolution reaction, which requires a current density of 500 mA/cm(2) at an overpotential below 300 mV with long-term stability. Here we report a robust oxygen-evolving electrocatalyst consisting of ferrous metaphosphate on self-supported conductive nickel foam that is commercially available in large scale...
May 15, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28495971/cilia-and-flagella-associated-protein-69-regulates-olfactory-transduction-kinetics-in-mice
#9
Anna K Talaga, Frederick N Dong, Johannes Reisert, Haiqing Zhao
Animals detect odorous chemicals through specialized olfactory sensory neurons (OSNs) that transduce odorants into neural electrical signals. We identify a novel and evolutionarily conserved protein, CFAP69, in mice that regulates olfactory transduction kinetics. In the olfactory epithelium CFAP69 is enriched in OSN cilia, where olfactory transduction occurs. Bioinformatic analysis suggests that a large portion of CFAP69 can form Armadillo-type α-helical repeats, which may mediate protein-protein interaction...
May 11, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28476536/translational-pharmacokinetic-pharmacodynamic-analysis-in-the-pharmaceutical-industry-an-iq-consortium-pk-pd-discussion-group-perspective
#10
Harvey Wong, Tonika Bohnert, Valeriu Damian-Iordache, Christopher Gibson, Cheng-Pang Hsu, Anu Shilpa Krishnatry, Bianca M Liederer, Jing Lin, Qiang Lu, Jerome T Mettetal, Daniel R Mudra, Marjoleen J M A Nijsen, Patricia Schroeder, Edgar Schuck, Satyendra Suryawanshi, Patrick Trapa, Alice Tsai, Haiqing Wang, Fan Wu
With inadequate efficacy being the primary cause for the attrition of drug candidates in clinical development, the need to better predict clinical efficacy earlier in the drug development process has increased in importance in the pharmaceutical industry. Here, we review current applications of translational pharmacokinetic-pharmacodynamic (PK-PD) modeling of preclinical data in the pharmaceutical industry, including best practices. Preclinical translational PK-PD modeling has been used in many therapeutic areas and has been impactful to drug development...
May 2, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/28475697/off-pump-coronary-artery-bypass-surgery-outcomes-in-patients-with-ischaemic-left-ventricular-systolic-dysfunction-with-or-without-detected-viable-myocardium
#11
Sen Li, Haiqing Li, Zhize Yuan, Baoli Zhang, Anqing Chen, Mi Zhou, Jun Liu, Junfeng Cai, Zhe Wang, Xiaofeng Ye, Qiang Zhao
OBJECTIVES: : The prognostic value of myocardial viability before coronary bypass grafting remains controversial. The present study evaluated the effects of off-pump coronary artery bypass (OPCAB) grafting on patients with coronary artery disease (CAD) with or without viable myocardium (VM) preoperatively detected via nuclear imaging. METHODS: : A total of 115 consecutive patients with 3-vessel disease and impaired left ventricular ejection fraction (LVEF ≤ 45%) who underwent OPCAB grafting were recruited in this prospective study...
May 5, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28473851/benefits-of-levothyroxine-replacement-therapy-on-nonalcoholic-fatty-liver-disease-in-subclinical-hypothyroidism-patients
#12
Lu Liu, Yong Yu, Meng Zhao, Dongmei Zheng, Xu Zhang, Qingbo Guan, Chao Xu, Ling Gao, Jiajun Zhao, Haiqing Zhang
Objectives. To evaluate the effect of levothyroxine (LT4) replacement therapy on nonalcoholic fatty liver disease (NAFLD) in subclinical hypothyroidism (SCH) patients. Methods. This study was a post hoc analysis of a randomized controlled trial and involved 33 significant and 330 mild SCH patients. All of the significant SCH patients received LT4 supplement. The mild SCH patients were grouped as LT4 treated or not. After 15 months of follow-up, prevalence of NAFLD in each group was reevaluated. Subgroup analysis was conducted in mild SCH patients with dyslipidemia...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28469770/fgf-16-protects-against-adverse-cardiac-remodeling-in-the-infarct-diabetic-heart
#13
Yanyan Hu, Li Li, Lin Shen, Haiqing Gao, Fei Yu, Wenbin Yin, Wei Liu
Till now, no functional studies for FGF-16 in diabetic heart have been reported. Therefore, this study aims to evaluate the potential function of FGF-16 in inhibiting adverse cardiac remodeling in post myocardial infarction (MI) of diabetic heart. We investigated the role of fibroblast growth factor-16 (FGF-16) in post-MI remodeling and role of cardio-protection in the diabetic infarct heart. Adult db/db diabetic mice were assigned to sham group, MI group and MI+FGF-16 group, respectively. MI group was induced by permanent coronary artery ligation, and the mice were subjected to 2D trans-thoracic echocardiography 2-4 weeks post-surgery...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28468412/helical-long-period-grating-manufactured-with-a-co-sub-2-sub-laser-on-multicore-fiber
#14
Shen Xiang, Hu Xiongwei, Yang Luyun, Dai Nengli, Wu Jianjun, Zhang Fangfang, Peng Jingang, Li Haiqing, Li Jinyan
We have demonstrated a helical long-period grating (HLPG) manufactured from multicore fiber (MCF) combined with twist and CO<sub>2</sub>-laser heating technology. The MCF we used behaves as a kind of single mode fiber. The nineteen cores of MCF are distributed hexagonally which make the helical structure only exist in core area after heating and twisting. There are several strong couplings between the core and cladding modes at different wavelengths when the grating pitch was 900 µm. The extinction ratio of the main coupling reached 20 dB at 1550 nm...
May 1, 2017: Optics Express
https://www.readbyqxmd.com/read/28465554/survival-changes-in-patients-with-small-cell-lung-cancer-and-disparities-between-different-sexes-socioeconomic-statuses-and-ages
#15
Shuncong Wang, Jianjun Tang, Tiantian Sun, Xiaobin Zheng, Jie Li, Hongliu Sun, Xiuling Zhou, Cuiling Zhou, Hongyu Zhang, Zhibin Cheng, Haiqing Ma, Huanhuan Sun
Small cell lung cancer (SCLC), as a proportion, makes up only 15-17% of lung cancer cases. The development of treatments for SCLC has remained stagnant for decades, and SCLC is expected to persist as a threat to human health. To date, no publications based on large populations have been reported. We calculated survival changes in patients with SCLC during each decade between 1983 and 2012 to determine the roles of race, sex, age, and socioeconomic status (SES) on survival rates based on the Surveillance, Epidemiology, and End Results (SEER) registries...
May 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28465495/pelvic-reconstruction-with-different-rod-screw-systems-following-enneking-type-i-i-iv-resection-a-clinical-study
#16
Peng Lin, Youyou Shao, Huigen Lu, Zhengliang Zhang, Haiqing Lin, Shengdong Wang, Binghao Li, Hengyuan Li, Zhan Wang, Nong Lin, Zhaoming Ye
The mechanical outcomes of patients with pelvic bone tumors involving zone I or zone I + IV who received resection and different reconstructions are not clear. Therefore, the purpose of this study was to compare the outcomes of different rod-screw systems in reconstruction for these patients, and evaluate the relative risk of mechanical failure for them. We reviewed 30 patients for a mean duration of 40.4 months of follow-up (range, 13.1-162.2 months), five patients had mechanical complications. The mechanical survival rate of two-rod and four-screw (TRFS) group was significantly higher than one-rod and two-screw (ORTS) group (p = 0...
April 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28459218/survival-improvement-in-patients-with-non-small-cell-lung-cancer-between-1983-and-2012-analysis-of-the-surveillance-epidemiology-and-end-results-database
#17
Shuncong Wang, Tiantian Sun, Huanhuan Sun, Xiaobo Li, Jie Li, Xiaobin Zheng, Saradhi Mallampati, Hongliu Sun, Xiuling Zhou, Cuiling Zhou, Hongyu Zhang, Zhibin Cheng, Haiqing Ma
Non-small cell lung cancer is the most common malignancy in males; it constitutes the majority of lung cancer cases and requires massive medical resources. Despite improvements in managing non-small cell lung cancer, long-term survival remains very low. This study evaluated survival improvement in patients with non-small cell lung cancer in each decade between 1983 and 2012 to determine the impact of race, sex, age, and socioeconomic status on the survival rates in these patients. We extracted data on non-small cell lung cancer cases in each decade between 1983 and 2012 from the Surveillance, Epidemiology, and End Results registries...
May 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28455983/pd-l1-expression-as-poor-prognostic-factor-in-patients-with-non-squamous-non-small-cell-lung-cancer
#18
Cuiling Zhou, Jianjun Tang, Huanhuan Sun, Xiaobin Zheng, Zhanyu Li, Tiantian Sun, Jie Li, Shuncong Wang, Xiuling Zhou, Hongliu Sun, Zhibin Cheng, Hongyu Zhang, Haiqing Ma
OBJECTIVES: The role of programmed cell death ligand 1 (PD-L1) in non-small cell lung cancer (NSCLC), especially according to histologic type, remains controversial. The purpose of this study was to assess PD-L1 expression and its association with overall survival (OS) and clinicopathologic characteristics in NSCLC. MATERIAL AND METHODS: Formalin-fixed paraffin-embedded specimens were obtained from 108 patients with surgically resected primary NSCLC. PD-L1 expression was assessed via immunohistochemistry using a histochemistry score system...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28448024/synthesis-of-hydrogels-with-antifouling-properties-as-membranes-for-water-purification
#19
Thien N Tran, Sankara N Ramanan, Haiqing Lin
Hydrogels have been widely utilized to enhance the surface hydrophilicity of membranes for water purification, increasing the antifouling properties and thus achieving stable water permeability through membranes over time. Here, we report a facile method to prepare hydrogels based on zwitterions for membrane applications. Freestanding films can be prepared from sulfobetaine methacrylate (SBMA) with a crosslinker of poly(ethylene glycol) diacrylate (PEGDA) via photopolymerization. The hydrogels can also be prepared by impregnation into hydrophobic porous supports to enhance the mechanical strength...
April 7, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28447711/alleviative-effect-of-grape-seed-proanthocyanidin-extract-on-small-artery-vascular-remodeling-in-spontaneous-hypertensive-rats-via-inhibition-of-collagen-hyperplasia
#20
Ying Liang, Haiqing Gao, Jian Wang, Quanzhen Wang, Shaohua Zhao, Jun Zhang, Jie Qiu
Vascular remodeling is a primary contributor to the initiation and development of hypertension, which has a pathological association with subsequent multi-organ damage. Grape seed proanthocyanidin extracts (GSPE) exhibit protective cardiovascular effects, resulting from their anti‑oxidant and anti‑inflammatory properties. However, the function and mechanism underlying the effect of GSPE on small artery remodeling remain to be elucidated. The present study investigated the effect of GSPE on vascular remodeling in the mesenteric small arteries of spontaneous hypertensive rats (SHR)...
May 2017: Molecular Medicine Reports
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