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https://www.readbyqxmd.com/read/29328376/identification-of-a-novel-compound-heterozygous-mutation-of-the-cyp21a2-gene-causing-21%C3%A2-hydroxylase-deficiency-in-a-chinese-pedigree
#1
Jia Liu, Xiujuan Zhang, Haiqing Zhang, Li Fang, Jin Xu, Qingbo Guan, Chao Xu
21‑Hydroxylase deficiency (21‑OHD) is the most common cause of congenital adrenal hyperplasia. Inherited in an autosomal recessive manner, 21‑OHD is caused by mutations in the cytochrome P450 family 21 subfamily A member 2 (CYP21A2) gene. The present study was designed to investigate the genetic characteristics of one Chinese pedigree and to identify the genotype‑phenotype association, thereby facilitating the precise diagnosis of 21‑OHD at the molecular level. Members of a Chinese family with 21‑OHD were screened for mutations in the CYP21A2 gene...
January 8, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29321521/coherence-measure-in-terms-of-the-tsallis-relative-%C3%AE-entropy
#2
Haiqing Zhao, Chang-Shui Yu
Coherence is the most fundamental quantum feature of the nonclassical systems. The understanding of coherence within the resource theory has been attracting increasing interest among which the quantification of coherence is an essential ingredient. A satisfactory measure should meet certain standard criteria. It seems that the most crucial criterion should be the strong monotonicity, that is, average coherence doesn't increase under the (sub-selective) incoherent operations. Recently, the Tsallis relative α entropy has been tried to quantify the coherence...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29317700/comparative-analysis-of-gene-expression-profiles-of-human-dental-fluorosis-and-kashin-beck-disease
#3
Qiang Zhang, Jing Ma, Haiqing Liu, Duolong He, Lilin Chen, Haikun Wu, Hong Jiang, Qing Lu, Shenglu Bai
To explore the pathologies of Kashin-Beck disease (KBD) and KBD accompanied with dental fluorosis (DF), we conducted a comparative analysis of gene expression profiles. 12 subjects were recruited, including 4 KBD patients, 4 patients with KBD and DF and 4 healthy subjects. Genome-wide expression profiles from their peripheral blood mononuclear cells were evaluated by customized oligonucleotide microarray. R programming software was used for the microarray data analysis followed by functional enrichment analysis through KOBAS...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29310407/shoulder-dislocation-combined-with-proximal-humerus-fracture-in-children-a-case-report-and-literature-review
#4
Sheng Jin, Haiqing Cai, Yunlan Xu
RATIONALE: Proximal humerus fracture occuring simultaneously with dislocation of a shoulder in children is extremely rare, with only a few recent reports of on such cases having been reported. PATIENT CONCERNS: A 6-year-old girl fell from a ladder and landed on her dominant right arm with pain in the right shoulder and unable to perform movements; her shoulder did not allow for passive movements as well. DIAGNOSES: Proximal humerus fracture combined with shoulder dislocation...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29284675/test-retest-reproducibility-for-the-tau-pet-imaging-agent-flortaucipir-f-18
#5
Michael D Devous, Abhinay D Joshi, Michael Navitsky, Sudeepti Southekal, Michael J Pontecorvo, Haiqing Shen, Ming Lu, William R Shankle, John P Seibyl, Ken Marek, Mark A Mintun
Background: Alzheimer's disease (AD) is characterized by beta-amyloid plaques (Aβ) and tau neurofibrillary tangles (NFTs). There are several PET imaging biomarkers for Aβ including 11C-PiB and 18F florbetapir. Recently, PET tracers for tau NFTs have become available and have shown utility in detection and monitoring of neurofibrillary pathology over time. Flortaucipir F 18 is one such tracer. Initial clinical studies indicated greater tau binding in AD and MCI patients compared to controls in a pattern consistent with tau pathology observed at autopsy...
December 28, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29239477/effect-of-incorporation-of-nature-chemicals-in-water-ice-glazing-on-freshness-and-shelf-life-of-pacific-saury-cololabis-saira-during-18-%C3%A2-c-frozen-storage
#6
Haibo Luo, Weihua Wang, Wei Chen, Haiqing Tang, Li Jiang, Zhifang Yu
BACKGROUND: Microbial spoilage and lipid oxidation are two major factors causing freshness deterioration of Pacific saury (Cololabis saira) during frozen storage. To provide a remedy, the effects of several natural chemicals incorporated alone or in combination in traditional water ice-glazing on the freshness and shelf-life of Pacific saury during frozen storage at -18 °C were investigated. Pacific sauries were subjected to individual quick freezing (IQF) followed by immediately dipping into cold tap water (control) or solutions containing nisin, chitosan, phytic acid (single-factor experiment) or their combinations [(L9 (34 ) orthogonal experiment] for 10 s at 1 °C, and then packaged in polypropylene bags before frozen storage at -18 °C...
December 14, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29218003/eye-drops-for-activation-of-dreadds
#7
William T Keenan, Diego C Fernandez, Lukas J Shumway, Haiqing Zhao, Samer Hattar
Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are an important tool for modulating and understanding neural circuits. Depending on the DREADD system used, DREADD-targeted neurons can be activated or repressed in vivo following a dose of the DREADD agonist clozapine-N-oxide (CNO). Because DREADD experiments often involve behavioral assays, the method of CNO delivery is important. Currently, the most common delivery method is intraperitoneal (IP) injection. IP injection is both a fast and reliable technique, but it is painful and stressful particularly when many injections are required...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/29207678/systematic-review-and-meta-analysis-of-the-prognostic-value-of-preoperative-platelet-to-lymphocyte-ratio-in-patients-with-urothelial-carcinoma
#8
Shuiqing Wu, Qi Wan, Ran Xu, Xuan Zhu, Haiqing He, Xiaokun Zhao
A large number of studies have investigated the prognostic value of the platelet-to-lymphocyte ratio (PLR) in patients diagnosed with urothelial carcinoma, but the evidence from these papers is conflicting. This systematic review and meta-analysis was carried out to assess the role of PLR in urothelial carcinoma patients. After a systematic search of the PubMed, Embase, Web of science databases, the associations between PLR and overall survival (OS), cancer-specific survival (CSS)/disease-specific survival (DSS), and relapse-free survival (RFS)/disease-free survival (DFS) were analyzed in urothelial carcinoma patients...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29188657/-synchronous-carcinoma-of-the-floor-of-mouth-carcinoma-with-esophageal-carcinoma-a-case-report
#9
Su Hua, Guo Xincheng, Wang Haiqing
This study presents a case of synchronous multiple primary cancers involving floor of mouth carcinoma with esophageal carcinoma. Literature was reviewed to summarize the incidence, location, diagnosis, treatment characteristics, and prognosis to improve understanding and awareness of the multiple primary cancer. As a result, early discovery, early diagnosis, and effective treatment can help prolong survival and improve the quality of life of patients.
October 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/29188246/fast-and-scalable-synthesis-of-uniform-zirconium-hafnium-based-metal-organic-framework-nanocrystals
#10
Ting He, Xiaobin Xu, Bing Ni, Haiqing Wang, Yong Long, Wenping Hu, Xun Wang
Metal-organic frameworks based on zirconium or hafnium possess tantalizing commercial prospects due to their high stability but require a long reaction time to form crystals. The fast synthesis of uniform Zr-, Hf-MOF nanocrystals at scale is of key importance in the potential commercial application of MOFs. In this work, we have developed a versatile strategy through controlling the hydrolysis and nucleation of metal salts in the presence of acetic acid and water; up to 24 grams of UiO-66-NH2 nanocrystals with a uniform octahedron could be synthesized within 15 minutes using a one step method...
November 30, 2017: Nanoscale
https://www.readbyqxmd.com/read/29179511/the-role-of-endobronchial-ultrasound-elastography-in-the-diagnosis-of-mediastinal-and-hilar-lymph-nodes
#11
Ye Gu, Hong Shi, Chunxia Su, Xiaoxia Chen, Shijia Zhang, Wei Li, Fengying Wu, Guanghui Gao, Hao Wang, Haiqing Chu, Caicun Zhou, Fei Zhou, Shengxiang Ren
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has been widely used for diagnosis and mediastinal lymph nodes staging in patients with suspicious lung cancer. Ultrasound elastography is a novel sonographical technique that can evaluate tissue compressibility. The aim of the present study was to investigate the diagnostic yield of elastography for differentiating malignant and benign mediastinal lymph nodes. Conventional EBUS B-mode features, including size, shape, border distinction, echogenicity, central hilar structure with central blood vessel and coagulation necrosis were also evaluated...
October 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/29167635/physical-exercise-promotes-novel-object-recognition-memory-in-spontaneously-hypertensive-rats-after-ischemic-stroke-by-promoting-neural-plasticity-in-the-entorhinal-cortex
#12
Xiaona Pan, Ting Jiang, Liying Zhang, Haiqing Zheng, Jing Luo, Xiquan Hu
Cerebral ischemia leads to memory impairment, and several studies have indicated that physical exercise (PE) has memory-improving effects after ischemia. This study was designed to further explore the specific role of PE in novel object recognition (NOR) memory after stroke and the exact cortical regions in which memory is restored by PE. Spontaneously hypertensive rats (SHR) were subjected to transient middle cerebral artery occlusion (tMCAO) or sham surgery, followed by 26 days of PE starting on day 3 post-tMCAO...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29165724/protective-effect-and-potential-mechanism-of-simvastatin-on-myocardial-injury-induced-by-diabetes-with-hypoglycemia
#13
Haiqing Li, Qianqian Zhao, Rong Liu, Lan Yang, Huanzhen Chen, Xiangli Cui
Background Simvastatin has been reported to reduce cardiovascular related morbidity and mortality in clinical trials which was independent of its cholesterol-lowering effect. This study aims to investigate the protective effect of simvastatin on myocardial injury caused by diabetic hypoglycemia and the possible underlying mechanism. Methods We used streptozotocin (STZ) at a dose of 55 mg/kg to induce diabetes mellitus (DM) and over-dose insulin to induce hypoglycemia to establish diabetic hypoglycemia rat models...
November 17, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29152654/nephrin-loss-is-reduced-by-grape-seed-proanthocyanidins-in-the-experimental-diabetic-nephropathy-rat-model
#14
Xianhua Li, Zhaoli Gao, Haiqing Gao, Baoying Li, Tao Peng, Bei Jiang, Xiangdong Yang, Zhao Hu
Diabetic nephropathy (DN) is one of the major causes of end‑stage renal failure. Grape seed proanthocyanidin extracts (GSPE) are known to act as antioxidants. The current study aimed to determine the effects of GSPE on the streptozotocin (STZ)‑induced diabetic rat model and to explore the underlying mechanism of its action. Wistar rats were induced into a diabetic state by injection of STZ and were treated with 250 mg·kg‑1·day‑1 GSPE for 24 weeks. Kidney samples were collected for observation of renal pathological changes by light microscope (periodic acid‑Schiff staining) and electron microscopy...
October 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29143257/environmental-characteristics-and-changes-of-sediment-pore-water-dissolved-organic-matter-in-four-chinese-lakes
#15
Khan M G Mostofa, Wen Li, Fengchang Wu, Cong-Qiang Liu, Haiqing Liao, Li Zeng, Min Xiao
Sediment pore waters were examined in four Chinese lakes (Bosten, Qinghai, Chenghai and Dianchi) to characterise the sources of dissolved organic matter (DOM) and their microbial changes in the sediment depth profiles. Parallel factor (PARAFAC) modelling on the sample fluorescence spectra confirmed that the pore water DOM was mostly composed of two components with a mixture of both allochthonous and autochthonous fulvic acid-like substances in three lakes, except Lake Dianchi, and protein-like components in Lake Bosten...
November 15, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29141829/cerebral-cortical-encephalitis-followed-by-recurrent-cns-demyelination-in-a-patient-with-concomitant-anti-mog-and-anti-nmda-receptor-antibodies
#16
Lei Zhou, Jingzi ZhangBao, Haiqing Li, Xiaoyang Li, Yongheng Huang, Min Wang, Chongbo Zhao, Jiahong Lu, Chuanzhen Lu, Yuxin Li, Chao Quan
We report the case of a patient who initially presented with fever, headache and seizure. MRI revealed a fluid attenuation inversion recovery (FLAIR) high-intensity lesion involving the right temporal, parietal and occipital cortex. Afterwards, the patient developed three recurrent episodes, manifested as brainstem encephalitis, optic neuritis and ADEM-like illness successively, indicating demyelination. Both of his serum anti-MOG and CSF anti-NMDAR antibodies were proved positive by transfected cell based assays...
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29137257/kaempferol-induces-hepatocellular-carcinoma-cell-death-via-endoplasmic-reticulum-stress-chop-autophagy-signaling-pathway
#17
Haiqing Guo, Wei Lin, Xiangying Zhang, Xiaohui Zhang, Zhongjie Hu, Liying Li, Zhongping Duan, Jing Zhang, Feng Ren
Kaempferol is a flavonoid compound that has gained widespread attention due to its antitumor functions. However, the underlying mechanisms are still not clear. The present study investigated the effect of kaempferol on hepatocellular carcinoma and its underlying mechanisms. Kaempferol induced autophagy in a concentration- and time-dependent manner in HepG2 or Huh7 cells, which was evidenced by the significant increase of autophagy-related genes. Inhibition of autophagy pathway, through 3-methyladenine or Atg7 siRNA, strongly diminished kaempferol-induced apoptosis...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29136110/meta-connectomic-analysis-reveals-commonly-disrupted-functional-architectures-in-network-modules-and-connectors-across-brain-disorders
#18
Zhiqiang Sha, Mingrui Xia, Qixiang Lin, Miao Cao, Yanqing Tang, Ke Xu, Haiqing Song, Zhiqun Wang, Fei Wang, Peter T Fox, Alan C Evans, Yong He
Neuropsychiatric disorders are increasingly conceptualized as disconnection syndromes that are associated with abnormal network integrity in the brain. However, whether different neuropsychiatric disorders show commonly dysfunctional connectivity architectures in large-scale brain networks remains largely unknown. Here, we performed a meta-connectomic study to identify disorder-related functional modules and brain regions by combining meta-analyses of 182 published resting-state functional MRI studies in 11 neuropsychiatric disorders and graph-theoretical analyses of 3 independent resting-state functional MRI datasets with healthy and diseased populations (Alzheimer's disease and major depressive disorder [MDD])...
November 9, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29135069/impaired-secretion-of-active-glp-1-in-patients-with-hypertriglyceridaemia-a-novel-lipotoxicity-paradigm
#19
Xiangxiang Wang, Jia Liu, Chaolin Li, Meng Zhao, Lu Liu, Qingbo Guan, Haiqing Zhang, Xu Zhang, Ling Gao, Jiajun Zhao, Yongfeng Song
AIM: Lipotoxicity plays an important role in the pathogenesis of β-cell dysfunction. Glucagon-like peptide-1 (GLP-1) is an incretin hormone that exerts beneficial effects on the number and function of islet β cells. However, the effect of lipotoxicity on GLP-1 secretion is still unknown. METHODS: Twenty-five patients who were newly diagnosed with diabetes were recruited from 400 subjects based on 75 g Oral Glucose Tolerance Test (OGTT). Patients were divided into diabetes (DM) and DM combined with hypertriglyceridaemia (DM+HTG) groups according to their serum triglyceride (TG) levels...
November 14, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29128492/expression-of-potassium-dependent-sodium-calcium-exchanger-in-the-murine-lens
#20
Alicia De Maria, Haiqing Zhao, Steven Bassnett
Loss of intracellular calcium homeostasis may contribute to the opacification of lens tissue during cortical cataract formation. In healthy lenses, the concentration of intracellular calcium is maintained at levels far below electrochemical equilibrium but the identity of the calcium extrusion mechanism in lens fiber cells has remained elusive. Previous studies focused on the role of plasma membrane calcium ATPases and sodium-calcium exchangers. Here, we examined the expression of mRNA transcripts encoding potassium-dependent sodium-calcium exchangers (Nckx's, encoded by the Slc24 gene family) in the mouse lens...
November 9, 2017: Experimental Eye Research
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