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https://www.readbyqxmd.com/read/27882107/effects-of-sitagliptin-as-initial-therapy-in-newly-diagnosed-elderly-type-2-diabetics-a-randomized-controlled-study
#1
Xiaoyan Xiao, Xiaopei Cui, Jianbo Zhang, Zhenxia Han, Yu Xiao, Nan Chen, Baoying Li, Mei Cheng, Haiqing Gao, Kuanxiao Tang
The objective of this study was to investigate the characteristics of blood glycemic excursion, incretins and pancreatic hormone secretion in elderly people with newly diagnosed type 2 diabetes mellitus (T2DM) and to study the effects of sitagliptin on glycemic excursion in these subjects. A total of 129 newly diagnosed T2DM patients were enrolled in the study from March 2012 to August 2013. Clinical data, serum incretin, pancreatic hormone and continuous glucose monitoring data were collected. Among these subjects, elderly patients (NEDM) randomly received metformin combined with sitagliptin phosphate or glimepiride for 24 weeks...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27864993/thyrotropin-alters-t-cell-development-in-the-thymus-in-subclinical-hypothyroidism-mouse-model
#2
Kunpeng Wu, Meng Zhao, Chunyan Ma, Haiqing Zhang, Xiaojing Liu, Lingyan Zhou, Jiajun Zhao, Ling Gao, Dan Wang
Subclinical hypothyroidism (SCH) is highly prevalent in the general population and is associated with potential deleterious effects. Although developing T cells express thyroid stimulating hormone receptor (TSH-R), the changes of T cell development in thymus in SCH have not been fully clarified. SCH mouse model, which is characterized by elevated serum TSH but similar thyroid hormone levels, were used to study the role of TSH in T cell development. Thymus weight of SCH mice increased 18% compared with controls...
November 16, 2016: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/27863436/chemotherapy-plus-dendritic-cells-co-cultured-with-cytokine-induced-killer-cells-versus-chemotherapy-alone-to-treat-advanced-non-small-cell-lung-cancer-a-meta-analysis
#3
Cuiling Zhou, Donglan Liu, Jie Li, Huanhuan Sun, Xiaobin Zheng, Shuncong Wang, Guobin Hong, Saradhi Mallampati, Hongliu Sun, Xiuling Zhou, Zhibin Cheng, Hongyu Zhang, Haiqing Ma
This study was aimed to investigate the efficacy and safety of the combination treatment of dendritic cells co-cultured with cytokine-induced killer cells and chemotherapy for patients with advanced non-small-cell lung cancer (NSCLC). Literatures were searched from the Cochrane Library Central, PubMed, Web of Science and EMBASE. The primary endpoint of interest was overall survival (OS), and secondary endpoints were disease control rate (DCR) and progression free survival (PFS). Finally 7 trials published between January 2005 and March 2016 met inclusion criteria and totally 610 patients were enrolled...
November 16, 2016: Oncotarget
https://www.readbyqxmd.com/read/27858890/mild-encephalopathy-with-a-reversible-splenial-lesion-mimicking-transient-ischemic-attack-a-case-report
#4
Kai Dong, Qian Zhang, Jianping Ding, Liankun Ren, Zhen Zhang, Longfei Wu, Wuwei Feng, Haiqing Song
BACKGROUND: Reversible splenial lesion syndrome (RESLES) is a newly recognized syndrome, and a reversible progress associated with transiently reduced diffusion lesion in the splenium of the corpus callosum (SCC) is the typical pathological finding. The routine clinical symptoms include mildly altered states of consciousness, delirium, and seizures. METHODS: We presented a 14-year-old patient with signs suggestive of transient ischemic attack (TIA), including triple episodic weakness on the right upper limb, slurred speech, and bucking, lasting several hours in each time 2 days ago...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27832700/systemic-correction-of-murine-glycogen-storage-disease-type-iv-by-an-aav-mediated-gene-therapy
#5
Haiqing Yi, Quan Zhang, Elizabeth D Brooks, Chunyu Yang, Beth L Thurberg, Priya S Kishnani, Baodong Sun
Deficiency of glycogen branching enzyme (GBE) causes glycogen storage disease type IV (GSD IV), which is characterized by the accumulation of a less branched, poorly soluble form of glycogen called polyglucosan (PG) in multiple tissues. We evaluate the efficacy of gene therapy with an adeno-associated viral (AAV) vector in a mouse model of adult form of GSD IV (<i>Gbe1<sup>ys/ys</sup></i>). An AAV serotype 9 (AAV9) vector containing a human GBE expression cassette (AAV-GBE) was intravenously injected into 14-day-old <i>Gbe1<sup>ys/ys</sup></i> mice at a dose of 5x10<sup>11</sup> vector genomes per mouse...
November 10, 2016: Human Gene Therapy
https://www.readbyqxmd.com/read/27827501/ligand-triggered-electrostatic-self-assembly-of-cds-nanosheet-au-nanocrystal-nanocomposites-for-versatile-photocatalytic-redox-applications
#6
Qingchi Xu, Jiaxin Zeng, Haiqing Wang, Xingyun Li, Jun Xu, Jianyang Wu, Guangcan Xiao, Fang-Xing Xiao, Xiangyang Liu
A facile and efficient ligand-triggered electrostatic self-assembly strategy has been developed to fabricate a series of Au/CdS nanosheet (Ns) (Au-CdS Ns) nanocomposites with varied weight addition ratios of Au nanoparticles (NPs) by judiciously utilizing the intrinsic surface charge properties of assembly units, through which uniform dispersion and controllable deposition of Au NPs on the CdS Ns were achieved. Versatile probe reactions including photocatalytic oxidation of an organic dye pollutant, selective photocatalytic reduction of aromatic nitro compounds and photocatalytic hydrogen production reactions under visible light irradiation and ambient conditions were used to systematically evaluate the photoredox performances of the as-assembled well-defined Au-CdS Ns nanocomposites...
December 7, 2016: Nanoscale
https://www.readbyqxmd.com/read/27805408/highly-efficient-hydrogen-evolution-from-edge-oriented-ws2-1-x-se2x-particles-on-three-dimensional-porous-nise2-foam
#7
Haiqing Zhou, Fang Yu, Jingying Sun, Hangtian Zhu, Ishwar Kumar Mishra, Shuo Chen, Zhifeng Ren
The large consumption of natural fossil fuels and accompanying environmental problems are driving the exploration of cost-effective and robust catalysts for hydrogen evolution reaction (HER) in water splitting. Tungsten dichalcogenides (WS2, WSe2, etc.) are promising candidates for such purpose, but their HER performances are inherently limited by the sparse catalytic edge sites and poor electrical conductivity. Here we demonstrate a highly active and stable HER catalyst by integrating ternary tungsten sulfoselenide WS2(1-x)Se2x particles with a 3D porous metallic NiSe2 foam, in which good electrical conductivity, good contact, high surface area, and high-density active edge sites are simultaneously obtained, thus contributing to good catalytic performance: large cathode current density (- 10 mA/cm2 at - 88 mV), low Tafel slope (46...
November 2, 2016: Nano Letters
https://www.readbyqxmd.com/read/27792924/production-of-%C3%AE%C2%B5-poly-lysine-by-streptomyces-albulus-pd-1-via-solid-state-fermentation
#8
Delei Xu, Haiqing Yao, Zhaoxian Xu, Rui Wang, Zheng Xu, Sha Li, Xiaohai Feng, Youhua Liu, Hong Xu
The aim of this study was to produce ε-poly-lysine (ε-PL) by Streptomyces albulus PD-1 through solid-state fermentation (SSF) using agro-industrial residues. Maximum ε-PL production (86.62mg/g substrate) was obtained a mixed substrate of rapeseed cake and wheat bran (2:1, w/w) supplemented with glucose (4%, w/w), (NH4)2SO4 (3%, w/w), with an initial moisture content of 65%, initial pH of 7.0 and inoculum size of 13% v/w, incubated at 30°C for 8days. The results of scanning electron microscopy indicated that the filamentous thallus could penetrate the substrate surface...
October 14, 2016: Bioresource Technology
https://www.readbyqxmd.com/read/27784237/the-roles-of-endoplasmic-reticulum-stress-in-the-pathophysiological-development-of-cartilage-and-chondrocytes
#9
Xiaoliang Yuan, Haiqing Liu, Linfu Li, Hai Liu, Jianqiong Yang, Weimei Shi, Longhuo Wu
Endoplasmic reticulum (ER) has evolved an adaptive mechanism called unfolded protein response (UPR) at the initial stage to restore cellular homeostasis. The three ER transmembrane sensors, including IRE1α, PERK, and ATF6 are the key factors to decide cell fates. They exhibit both advantageous and disadvantageous effects, which depending on the micro-environmental state of cells. ER stress has been implicated in chondrocytes proliferation, differentiation, and hypertrophy through regulating transcriptional factors SOX9, Ihh, BMP-2, RUNX, and HIF1/2α...
October 25, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27753266/environmentally-friendly-solid-phase-microextraction-coupled-with-gas-chromatography-and-mass-spectrometry-for-the-determination-of-biogenic-amines-in-fish-samples
#10
Jie Huang, Ning Gan, Fangying Lv, Yuting Cao, Changrong Ou, Haiqing Tang
In this work, a facile and environmentally friendly solid-phase microextraction assay based on on-fiber derivatization coupled with gas chromatography and mass spectrometry was developed for determining four nonvolatile index biogenic amines (putrescine, cadaverine, histamine, and tyramine) in fish samples. In the assay, the fiber was firstly dipped into a solution with isobutyl chloroformate as derivatization reagent and isooctane as extraction solvent. Thus, a thin organic liquid membrane coating was developed...
October 18, 2016: Journal of Separation Science
https://www.readbyqxmd.com/read/27747161/alglucosidase-alfa-treatment-alleviates-liver-disease-in-a-mouse-model-of-glycogen-storage-disease-type-iv
#11
Haiqing Yi, Fengqin Gao, Stephanie Austin, Priya S Kishnani, Baodong Sun
Patients with progressive hepatic form of GSD IV often die of liver failure in early childhood. We tested the feasibility of using recombinant human acid-α glucosidase (rhGAA) for treating GSD IV. Weekly intravenously injection of rhGAA at 40 mg/kg for 4 weeks significantly reduced hepatic glycogen accumulation, lowered liver/body weight ratio, and reduced plasma ALP and ALT activities in GSD IV mice. Our data suggests that rhGAA is a potential therapy for GSD IV.
December 2016: Molecular Genetics and Metabolism Reports
https://www.readbyqxmd.com/read/27723130/structurally-defined-3d-nanographene-assemblies-via-bottom-up-chemical-synthesis-for-highly-efficient-lithium-storage
#12
Hung-Ju Yen, Hsinhan Tsai, Ming Zhou, Edward F Holby, Samrat Choudhury, Aiping Chen, Lyudmyla Adamska, Sergei Tretiak, Timothy Sanchez, Srinivas Iyer, Hanguang Zhang, Lingxiang Zhu, Haiqing Lin, Liming Dai, Gang Wu, Hsing-Lin Wang
Functionalized 3D nanographenes with controlled electronic properties have been synthesized through a multistep organic synthesis method and are further used as promising anode materials for lithium-ion batteries, exhibiting a much increased capacity (up to 950 mAh g(-1) ), three times higher than that of the graphite anode (372 mAh g(-1) ).
October 10, 2016: Advanced Materials
https://www.readbyqxmd.com/read/27717156/combining-arterial-spin-labeling-with-functional-magnetic-resonance-imaging-measurement-for-characterizing-patients-with-minimal-hepatic-encephalopathy
#13
Ying Li, Huaijun Liu, Jiping Yang, Xin Tian, Haiqing Yang, Zuojun Geng
AIM: Our objective is to explore key changes in brain functions in relation to minimal hepatic encephalopathy (MHE). We incorporated both resting-state functional magnetic resonance imaging (fMRI) and arterial spin labeling (ASL) to enhance the detection of MHE. METHODS: We undertook fMRI scanning for 56 MHE patients and 66 healthy controls. Region functional connectivity was carried out to assess the connectivity status between pairs of regions among 90 brain regions...
October 7, 2016: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/27716784/the-mechanism-of-proinflammatory-hdl-generation-in-sickle-cell-disease-is-linked-to-cell-free-hemoglobin-via-haptoglobin
#14
Xiang Ji, Yimin Feng, Hui Tian, Wei Meng, Weiling Wang, Na Liu, Jun Zhang, Lingshu Wang, Jian Wang, Haiqing Gao
In sickle cell disease (SCD), the inflammatory properties of high-density lipoprotein (HDL) can be changed by cell-free hemoglobin (Hb), which is released into the blood during hemolysis. Hb in the plasma of SCD patients or mice can bind with HDL specifically inducing an inflammatory reaction. In our study, we found increased amounts of inflammatory factor proteins in the chronic oxidative state of SCD with higher levels of Hb, haptoglobin (Hp) and hemopexin (Hx) in the apolipoprotein A-I (ApoA-1) particles of HDL and the role of HDL is changed from being anti-inflammatory to proinflammatory...
2016: PloS One
https://www.readbyqxmd.com/read/27686654/structural-insights-into-ire1-functions-in-the-unfolded-protein-response
#15
Jianqiong Yang, Haiqing Liu, Linfu Li, Hai Liu, Weimei Shi, Xiaoliang Yuan, Longhuo Wu
IRE1 signaling is the most evolutionarily conserved branch in the UPR. IRE1 is an ER stress sensor and provides a structure-based platform for the unfolded proteins docking, which causes the luminal domain conformational change and oligomerization. This self-association of IRE1 facilitates the phosphorylation of activation loop, which unlocks the auto-inhibition in the kinase domain. The activating mechanistic cascade is thus initiated to induce DFG-in conformational change and movement of αC-helix to the active site...
September 27, 2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/27684849/elastic-stable-intramedullary-nailing-for-severely-displaced-distal-tibial-fractures-in-children
#16
Kaiying Shen, Haiqing Cai, Zhigang Wang, Yunlan Xu
Elastic stable intramedullary nailing (ESIN) has became a well-accepted method of osteosynthesis of diaphyseal fractures in the skeletally immature patient for many advantages, the purpose of this study is to evaluate the preliminary results of this minimally invasive treatment for severely displaced distal tibial diaphyseal metaphyseal junction (DTDMJ) fractures.This study was carried out over a 6-year period. Twenty-one severely displaced DTDMJ fractures treated using ESIN were evaluated clinically and radiographically...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27682129/evaluation-of-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry-for-identification-of-mycobacterium-abscessus-subspecies-according-to-whole-genome-sequencing
#17
Liulin Luo, Weijia Liu, Bing Li, Mengling Li, Dongdong Huang, Linjie Jing, Huiping Chen, Jinghui Yang, Jun Yue, Fang Wang, Haiqing Chu, Zhemin Zhang
This study was undertaken to evaluate the utility of matrix-assisted laser desorption ionization-time of flight mass spectrometry with the Vitek MS Plus system for identifying Mycobacterium abscessus subspecies in order to facilitate more rapid and appropriate therapy. A total of 175 clinical M. abscessus strains were identified by whole genome sequencing analysis: 139 M. abscessus subsp. abscessus and 36 M. abscessus subsp. massiliense The research-use-only (RUO) Saramis Knowledge Base database V.4.12 was modified accordingly by adding 40 M...
September 28, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27668122/capitalizing-resolving-power-of-density-gradient-ultracentrifugation-by-freezing-and-precisely-slicing-centrifuged-solution-enabling-identification-of-complex-proteins-from-mitochondria-by-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry
#18
Haiqing Yu, Joann J Lu, Wei Rao, Shaorong Liu
Density gradient centrifugation is widely utilized for various high purity sample preparations, and density gradient ultracentrifugation (DGU) is often used for more resolution-demanding purification of organelles and protein complexes. Accurately locating different isopycnic layers and precisely extracting solutions from these layers play a critical role in achieving high-resolution DGU separations. In this technique note, we develop a DGU procedure by freezing the solution rapidly (but gently) after centrifugation to fix the resolved layers and by slicing the frozen solution to fractionate the sample...
2016: Journal of Analytical Methods in Chemistry
https://www.readbyqxmd.com/read/27639197/toxicity-of-cerium-and-thorium-on-daphnia-magna
#19
Yuhui Ma, Jingkun Wang, Can Peng, Yayun Ding, Xiao He, Peng Zhang, Na Li, Tu Lan, Dongqi Wang, Zhaohui Zhang, Fuhong Sun, Haiqing Liao, Zhiyong Zhang
Cerium (Ce) and thorium (Th) are always thought to be chemically similar and have comparable toxic properties on living organisms. In the present study, the acute and chronic toxicity of these two elements to freshwater crustacean Daphnia magna were investigated in the modified reconstituted water (6mg/L KCl, 123mg/L MgSO4·7H2O, and 294mg/L CaCl2·2H2O in Milli-Q water, pH 7.8). It seemed that Ce and Th had comparable acute toxicity on Daphnia: 24/48h EC50 for Th and Ce were 7.3/4.7μM and 16.4/10.7μM, respectively...
September 14, 2016: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27633712/efficient-hydrogen-evolution-by-ternary-molybdenum-sulfoselenide-particles-on-self-standing-porous-nickel-diselenide-foam
#20
Haiqing Zhou, Fang Yu, Yufeng Huang, Jingying Sun, Zhuan Zhu, Robert J Nielsen, Ran He, Jiming Bao, William A Goddard Iii, Shuo Chen, Zhifeng Ren
With the massive consumption of fossil fuels and its detrimental impact on the environment, methods of generating clean power are urgent. Hydrogen is an ideal carrier for renewable energy; however, hydrogen generation is inefficient because of the lack of robust catalysts that are substantially cheaper than platinum. Therefore, robust and durable earth-abundant and cost-effective catalysts are desirable for hydrogen generation from water splitting via hydrogen evolution reaction. Here we report an active and durable earth-abundant transition metal dichalcogenide-based hybrid catalyst that exhibits high hydrogen evolution activity approaching the state-of-the-art platinum catalysts, and superior to those of most transition metal dichalcogenides (molybdenum sulfide, cobalt diselenide and so on)...
2016: Nature Communications
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