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Khan M G Mostofa, Wen Li, Fengchang Wu, Cong-Qiang Liu, Haiqing Liao, Li Zeng, Min Xiao
Sediment pore waters were examined in four Chinese lakes (Bosten, Qinghai, Chenghai and Dianchi) to characterise the sources of dissolved organic matter (DOM) and their microbial changes in the sediment depth profiles. Parallel factor (PARAFAC) modelling on the sample fluorescence spectra confirmed that the pore water DOM was mostly composed of two components with a mixture of both allochthonous and autochthonous fulvic acid-like substances in three lakes, except Lake Dianchi, and protein-like components in Lake Bosten...
November 15, 2017: Environmental Science and Pollution Research International
Lei Zhou, Jingzi ZhangBao, Haiqing Li, Xiaoyang Li, Yongheng Huang, Min Wang, Chongbo Zhao, Jiahong Lu, Chuanzhen Lu, Yuxin Li, Chao Quan
We report the case of a patient who initially presented with fever, headache and seizure. MRI revealed a fluid attenuation inversion recovery (FLAIR) high-intensity lesion involving the right temporal, parietal and occipital cortex. Afterwards, the patient developed three recurrent episodes, manifested as brainstem encephalitis, optic neuritis and ADEM-like illness successively, indicating demyelination. Both of his serum anti-MOG and CSF anti-NMDAR antibodies were proved positive by transfected cell based assays...
November 2017: Multiple Sclerosis and related Disorders
Haiqing Guo, Wei Lin, Xiangying Zhang, Xiaohui Zhang, Zhongjie Hu, Liying Li, Zhongping Duan, Jing Zhang, Feng Ren
Kaempferol is a flavonoid compound that has gained widespread attention due to its antitumor functions. However, the underlying mechanisms are still not clear. The present study investigated the effect of kaempferol on hepatocellular carcinoma and its underlying mechanisms. Kaempferol induced autophagy in a concentration- and time-dependent manner in HepG2 or Huh7 cells, which was evidenced by the significant increase of autophagy-related genes. Inhibition of autophagy pathway, through 3-methyladenine or Atg7 siRNA, strongly diminished kaempferol-induced apoptosis...
October 10, 2017: Oncotarget
Zhiqiang Sha, Mingrui Xia, Qixiang Lin, Miao Cao, Yanqing Tang, Ke Xu, Haiqing Song, Zhiqun Wang, Fei Wang, Peter T Fox, Alan C Evans, Yong He
Neuropsychiatric disorders are increasingly conceptualized as disconnection syndromes that are associated with abnormal network integrity in the brain. However, whether different neuropsychiatric disorders show commonly dysfunctional connectivity architectures in large-scale brain networks remains largely unknown. Here, we performed a meta-connectomic study to identify disorder-related functional modules and brain regions by combining meta-analyses of 182 published resting-state functional MRI studies in 11 neuropsychiatric disorders and graph-theoretical analyses of 3 independent resting-state functional MRI datasets with healthy and diseased populations (Alzheimer's disease and major depressive disorder [MDD])...
November 9, 2017: Cerebral Cortex
Xiangxiang Wang, Jia Liu, Chaolin Li, Meng Zhao, Lu Liu, Qingbo Guan, Haiqing Zhang, Xu Zhang, Ling Gao, Jiajun Zhao, Yongfeng Song
AIM: Lipotoxicity plays an important role in the pathogenesis of β-cell dysfunction. Glucagon-like peptide-1 (GLP-1) is an incretin hormone that exerts beneficial effects on the number and function of islet β cells. However, the effect of lipotoxicity on GLP-1 secretion is still unknown. METHODS: Twenty-five patients who were newly diagnosed with diabetes were recruited from 400 subjects based on 75 g Oral Glucose Tolerance Test (OGTT). Patients were divided into diabetes (DM) and DM combined with hypertriglyceridaemia (DM+HTG) groups according to their serum triglyceride (TG) levels...
November 14, 2017: Diabetes/metabolism Research and Reviews
Alicia De Maria, Haiqing Zhao, Steven Bassnett
Loss of intracellular calcium homeostasis may contribute to the opacification of lens tissue during cortical cataract formation. In healthy lenses, the concentration of intracellular calcium is maintained at levels far below electrochemical equilibrium but the identity of the calcium extrusion mechanism in lens fiber cells has remained elusive. Previous studies focused on the role of plasma membrane calcium ATPases and sodium-calcium exchangers. Here, we examined the expression of mRNA transcripts encoding potassium-dependent sodium-calcium exchangers (Nckx's, encoded by the Slc24 gene family) in the mouse lens...
November 9, 2017: Experimental Eye Research
Wenbo Zhao, Ruiwen Che, Shuyi Shang, Chuanjie Wu, Chuanhui Li, Longfei Wu, Jian Chen, Jiangang Duan, Haiqing Song, Hongqi Zhang, Feng Ling, Yuping Wang, David Liebeskind, Wuwei Feng, Xunming Ji
BACKGROUND AND PURPOSE: Chinese patients largely experience acute ischemic stroke (AIS) because of large artery atherosclerosis rather than cardioembolism, and whether tirofiban is safe and effective in these patients treated with endovascular thrombectomy (ET) is unknown. This study evaluated the safety and efficacy of tirofiban in Chinese patients with AIS treated with ET. METHODS: This observational study is based on a single-center prospective registry study...
November 10, 2017: Stroke; a Journal of Cerebral Circulation
ZhiPeng Yu, Kai Dong, Hong Chang, XiaoQin Huang, Yi Ren, ChunQiu Fan, QingFeng Ma, HaiQing Song, Qian Zhang, Jing Zhang, LiYuan Huang
To survey the epidemiological characteristics and clinical features on epilepsy in eight ethnic groups in Yunnan province of China. METHODES: The investigation was based on the WHO questionnaire and ICBERG screening questionnaire. This study was performed through random cluster sampling and door-to-door survey. RESULTS: A total of 76,302 individuals from eight ethnic groups were surveyed. The crude prevalence of epilepsy ranged from 1.2/1000 to 6.5/1000 in the eight ethnic groups, and the age-adjusted prevalence of epilepsy was from 2...
November 7, 2017: Epilepsy Research
Da Zhou, Ran Meng, Xuxiang Zhang, Linlin Guo, Sijie Li, Weijuan Wu, Jiangang Duan, Haiqing Song, Yuchuan Ding, Xunming Ji
BACKGROUND: Idiopathic intracranial hypertension (IIH) is characterized by abnormally elevated intracranial pressure (ICP) without identifiable etiology. Recently, however, a subset of patients with presumed IIH have been found with isolated internal jugular vein (IJV) stenosis in the absence of intracranial abnormalities. METHODS: Fifteen consecutive patients were screened from 46 patients suspected as IIH and were finally confirmed as isolated IJV stenosis. The stenotic IJV was corrected with stenting when a trans-stenotic mean pressure gradient (∆MPG) was equal or higher than 5...
November 8, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
Rong Cai, Rongfeng Song, Pengfei Pang, Yan Yan, Yifeng Liao, Cuiling Zhou, Shuncong Wang, Xiuling Zhou, Huaping Wang, Hongyu Zhang, Huanhuan Sun, Haiqing Ma
BACKGROUND: Many studies have combined sorafenib with transcatheter arterial chemoembolization (TACE) to treat patients with advanced hepatocellular carcinoma (HCC), but the results are disputable. Thus, we conducted this meta-analysis to assess the efficacy and safety of the combination treatment in patients with advanced HCC. METHODS: Clinical data were collected from a computer search of literature published from January 2009 to June 2016 in PubMed, Web of Science, the Cochrane Library, China National Knowledge Infrastructure (CNKI), Wan Fang and the China Science and Technology Journal Database (CSTJ)...
November 6, 2017: BMC Cancer
Haiqing Ye, Qian Li, Zhengzhe Zhang, Maocheng Sun, Changhui Zhao, Tiehua Zhang
Nonalcoholic fatty liver disease (NAFLD) is the main cause of chronic liver disease worldwide. Previous evidence indicates that probiotics can be applied as a therapeutic agent for NAFLD. In this study, the potential probiotic strain Lactobacillus paracasei Jlus66 was isolated from natural fermented milk by a culture-dependent method, and its probiotic potentials were tested by established in vitro tests. In addition, the protective effect of Lactobacillus paracasei Jlus66 against NAFLD was evaluated in rat models...
November 6, 2017: Food & Function
Weijia Liu, Bing Li, Haiqing Chu, Zhemin Zhang, Liulin Luo, Wei Ma, Shiyi Yang, Qi Guo
Clarithromycin resistance is increasing dramatically among Mycobacterium abscessus complex. The main resistance mechanisms are mutations in the erm(41) and rrl genes. Here we report PCR-based denaturing gradient gel electrophoresis (DGGE) as an alternative method for rapidly detection of mutations in erm(41) and rrl among M. abscessus isolates. Four primer sets targeting the full-length erm(41) gene and a 354bp fragment of the rrl gene were designed. A combination of 16 different DGGE patterns were observed for erm(41) gene, including 16 in M...
October 24, 2017: Journal of Microbiological Methods
Shen Tang, Yuyang Liu, Xinhang Wang, Ziwei Liang, Haiqing Cai, Laiming Mo, Deqiang Xiao, Songchao Guo, Yiqiang Ouyang, Bin Sun, Cailing Lu, Xiyi Li
PP2Acα2 is a recently discovered PP2Acα alternative splicing isoform that can be induced following serum withdrawal. It shows enhanced binding to immunoglobulin binding protein 1 and is overexpressed in chronic lymphocytic leukemia patients. Current knowledge concerning PP2Acα2 is limited. In this study, we induced and cloned PP2Acα2 from HL-60 cells and human lymphocytes, transfected them into human embryonic kidney 293 cells and constructed a stable overexpression cell line. We found that PP2Acα2 mRNA inhibits expression of its longer isoform PP2Acα mRNA but had no effect on the final protein expression and modification of this longer isoform...
October 21, 2017: Biochemical and Biophysical Research Communications
Haoshi Zhang, Lan Tian, Huiyang Lu, Ming Zhou, Haiqing Zou, Peng Fang, Fuan Yao, Guanglin Li
Continuous electrocardiogram (ECG) monitoring is significant for prevention of heart disease and is becoming an important part of personal and family health care. In most of the existing wearable solutions, conventional metal sensors and corresponding chips are simply integrated into clothes and usually could only collect few leads of ECG signals that could not provide enough information for diagnosis of cardiac diseases such as arrhythmia and myocardial ischemia. In this study, a wearable 12-lead ECG acquisition system with fabric electrodes was developed and could simultaneously process 12 leads of ECG signals...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Mingxing Zhu, Faya Liang, Oluwarotimi Williams Samuel, Shixiong Chen, Wanzhang Yang, Lin Lu, Haiqing Zou, Peng Li, Guanglin Li
Phonation is controlled by complex synergism of muscles over the front neck region. Proper evaluation of the muscular activities in this region would not only help to estimate phonation function, but may also provide characteristics to diagnose dysphonia. While surface electromyography (sEMG) technique has been used to study the physiological aspects of phonation in previous studies, it remains unclear if the phonating function could be dynamically characterized by the sEMG signals of the neck muscles associated with phonation...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Haiqing Bai, Gillian M Schiralli Lester, Laura C Petishnok, David A Dean
Productive transfection and gene transfer requires not simply entry of DNA into cells and subsequent transcription from an appropriate promoter, but also a number of intracellular events that allow the DNA to move from the extracellular surface of the cell into and through the cytoplasm, and ultimately across the nuclear envelope and into the nucleus before any transcription can initiate. Immediately upon entry into the cytoplasm, naked DNA, either delivered through physical techniques or after disassembly of DNA-carrier complexes, associates with a large number of cellular proteins that mediate subsequent interactions with the microtubule network for movement towards the microtubule organizing center and the nuclear envelope...
October 20, 2017: Bioscience Reports
Haiqing Wang, Lei Li, Wentao Bo, Aixiang Liu, Xielin Feng, Yong Hu, Lang Tian, Hui Zhang, Xiaoli Tang, Lixia Zhang, Mingyi Zhang
BACKGROUND: Postoperative liver failure remains the main complication and predominant cause of hepatectomy-related mortality for patients undergoing liver resection. AIM: Our aim is to investigate whether immediate postoperative Fibrosis-4 could predict postoperative liver failure. METHODS: We retrospectively enrolled 1353 consecutive hepatocellular carcinoma patients undergoing radical resection. The characteristics and clinical outcomes were compared between patients with high and low immediate postoperative Fibrosis-4...
October 4, 2017: Digestive and Liver Disease
Fengze Sun, Huanhuan Sun, Xiangqiong Mo, Jianjun Tang, Yifeng Liao, Shuncong Wang, Yonghui Su, Haiqing Ma
BACKGROUND: Gastric cancer (GC) has the fifth highest incidence rate of all cancers and has a poor prognosis. However, no recent large-scale and long-term studies have evaluated the incidence and survival rates of individuals with GC. METHODS: In order to explore the change of GC incidence and survival rates by age, gender, race, socioeconomic status (SES), incidence data and survival status of patients with GC between 1984 and 2013 were abstracted from the Surveillance, Epidemiology and End Results (SEER) database...
October 19, 2017: Journal of Gastroenterology and Hepatology
Wang Qin, Jixiang Li, Jianbing Tu, Hongqin Yang, Qinhui Chen, Haiqing Liu
Low temperature thermally induced phase separation (LT-TIPS) of chitosan solution was developed to fabricate porous chitosan membranes (p-CSMs), which were composed of short nanofibers with diameter of 40-60nm. Compared to the conventional acetic acid/water solvent, a mixed solvent of acetic acid/ethanol/water was used to prepare chitosan solution. The effect of solvent composition, quenching temperature and time, and coagulant on the p-CSM morphology were systematically explored. The optimum conditions for fabricating p-CSM was to quench 2% chitosan/2% acetic acid in water/ethanol (70/30) at -20°C for 12h, followed by coagulating in 1% Na2CO3 in water/ethanol (50/50)...
December 15, 2017: Carbohydrate Polymers
Zhongwei Xu, Xing Luo, Luyun Yang, Jinggang Peng, Haiqing Li, Jinyan Li
We report on a passively Q-switched Yb-doped all-fiber (YDF) ring laser based on stimulated Brillouin scattering (SBS) feedback in a 20-m single-mode fiber (SMF). The Q-switched pulses are generated from the Stokes pulses of SBS and amplified in the YDF. The 10-ns self-Q-switched pulses with ∼1  kW maximum peak power are obtained. The repetition frequency of the pulse train is tuned from 4 to 12.6 kHz by changing the pump power in the experiment. A bandpass filter inserted in the laser cavity was used to suppress the time jitter of the Q-switched pulses...
June 10, 2017: Applied Optics
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