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https://www.readbyqxmd.com/read/28101153/upregulated-effects-of-mir-7-in-methicillin-resistant-staphylococcus-aureus
#1
Hong Zhang, Haiqing Li, Yan Liu, Qingyan Li, Yufang Bi, Guiqing Fang
The aim of the study was to investigate the characteristic function of the upregulated effects of miR-7 in methicillin-resistant Staphylococcus aureus (MRSA). After separating the MRSA in clinic, the expression of miR-7 mRNA was tested by reverse transcription polymerase chain reaction. The overexpression, inhibition of miR-7, and control group were established by plasmid in vitro. Following transfection of the bacterial strain, the effect of β-lactam antibiotics in minimum inhibitory concentration (MIC) was observed using the microporous dilution method, and antibacterial effects in vitro were observed using the dynamic growth curve method...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28099350/retrospective-observational-study-comparing-the-international-hip-dysplasia-institute-classification-with-the-tonnis-classification-of-developmental-dysplasia-of-the-hip
#2
Mingyuan Miao, Haiqing Cai, Liwei Hu, Zhigang Wang
The Tonnis radiographic classification of developmental dysplasia of the hip (DDH) has been widely used. The International Hip Dysplasia Institute (IHDI) classification, a new classification system recently developed by the IHDI, is beginning to be applied to evaluate DDH with the absence of an ossification center. This study aimed to validate its reliability in evaluating DDH with an ossification center and compared the 2 classifications in evaluating all DDH hips. In addition, the prediction values of the 2 classifications on clinical management selection were compared...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28099343/efficacy-and-safety-of-bisphosphonates-in-management-of-low-bone-density-in-inflammatory-bowel-disease-a-meta-analysis
#3
Liwei Yao, Haiqing Wang, Wenwei Dong, Zhenxin Liu, Haijiao Mao
This study aims to determine whether bisphosphonates are safe, as well as effective against bone mineral loss in inflammatory bowel disease (IBD). A computerized search of electronic databases from 1966 to 2016 was performed. Randomized controlled trials (RCTs) were included in this review to evaluate the role of bisphosphonates in the management of osteoporosis in IBD patients. A revised 7-point Jadad scale was used to evaluate the quality of each study. Overall, 13 RCTs and 923 patients met the inclusion criteria of this meta-analysis...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28099141/antitumor-activity-of-a-trans-thiosemicarbazone-schiff-base-palladium-ii-complex-on-human-gastric-adenocarcinoma-cells
#4
Bingchang Zhang, Haiqing Luo, Qinjuan Xu, Lirong Lin, Bing Zhang
The development of transition-metal-based antitumor drug candidates increases the metallopharmaceuticals study dramatically. Two trans-thiosemicarbazone-based, Schiff base palladium (Pd) (II) complexes, DMABTSPd (TSPd) and DMABPTSPd (PTSPd), were prepared and characterized as described in our previous study. Here, we investigated whether the two complexes have antitumor effect on human gastric adenocarcinoma cell lines, BGC-823 and SGC-7901, compared with normal human gastric mucosal epithelial cell line, Ges-1...
January 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28098186/a-novel-multi-target-regression-framework-for-time-series-prediction-of-drug-efficacy
#5
Haiqing Li, Wei Zhang, Ying Chen, Yumeng Guo, Guo-Zheng Li, Xiaoxin Zhu
Excavating from small samples is a challenging pharmacokinetic problem, where statistical methods can be applied. Pharmacokinetic data is special due to the small samples of high dimensionality, which makes it difficult to adopt conventional methods to predict the efficacy of traditional Chinese medicine (TCM) prescription. The main purpose of our study is to obtain some knowledge of the correlation in TCM prescription. Here, a novel method named Multi-target Regression Framework to deal with the problem of efficacy prediction is proposed...
January 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28097811/fc-silent-anti-cd154-domain-antibody-effectively-prevents-non-human-primate-renal-allograft-rejection
#6
Steven C Kim, Walter Wakwe, Laura B Higginbotham, David V Mathews, Cynthia P Breeden, Allison C Stephenson, Joe Jenkins, Elizabeth Strobert, Karen Price, Laura Price, Robert Kuhn, Haiqing Wang, Aaron Yamniuk, Suzanne Suchard, Alton B Farris, Thomas C Pearson, Christian P Larsen, Mandy L Ford, Anish Suri, Steven Nadler, Andrew B Adams
The advent of costimulation blockade provides the prospect for targeted therapy with improved graft survival in transplant patients. Perhaps the most effective costimulation blockade in experimental models is the use of reagents to block the CD40/CD154 pathway. Unfortunately, successful clinical translation of anti-CD154 therapy has not been achieved. In an attempt to develop an agent that is as effective as previous CD154 blocking antibodies but lacks the risk of thromboembolism, we evaluated the efficacy and safety of a novel anti-human CD154 domain antibody (dAb, BMS-986004)...
January 17, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28094769/ipsc-derived-%C3%AE-cells-model-diabetes-due-to-glucokinase-deficiency
#7
Haiqing Hua, Linshan Shang, Hector Martinez, Matthew Freeby, Mary Pat Gallagher, Thomas Ludwig, Liyong Deng, Ellen Greenberg, Charles LeDuc, Wendy K Chung, Robin Goland, Rudolph L Leibel, Dieter Egli
No abstract text is available yet for this article.
January 17, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28070745/considering-total-intracranial-volume-and-other-nuisance-variables-in-brain-voxel-based-morphometry-in-idiopathic-pd
#8
Samuel Crowley, Haiqing Huang, Jared Tanner, Qing Zho, Nadine A Schwab, Loren Hizel, Daniel Ramon, Babette Brumback, Mingzhou Ding, Catherine C Price
Voxel-based morphometry (VBM) studies of Parkinson's disease (PD), have yielded mixed results, possibly due to several studies not accounting for common nuisance variables (age, sex, and total intracranial volume [TICV]). TICV is particularly important because there is evidence for larger TICV in PD. We explored the influence of these covariates on VBM by 1) comparing PD patients and controls before adding covariates, after adding age and sex, and after adding age, sex and TICV, and 2) by comparing controls split into large and small TICV before and after controlling for TICV, with age and sex accounted for in both analyses...
January 9, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28069946/wnt5a-is-essential-for-hippocampal-dendritic-maintenance-and-spatial-learning-and-memory-in-adult-mice
#9
Chih-Ming Chen, Lauren L Orefice, Shu-Ling Chiu, Tara A LeGates, Samer Hattar, Richard L Huganir, Haiqing Zhao, Baoji Xu, Rejji Kuruvilla
Stability of neuronal connectivity is critical for brain functions, and morphological perturbations are associated with neurodegenerative disorders. However, how neuronal morphology is maintained in the adult brain remains poorly understood. Here, we identify Wnt5a, a member of the Wnt family of secreted morphogens, as an essential factor in maintaining dendritic architecture in the adult hippocampus and for related cognitive functions in mice. Wnt5a expression in hippocampal neurons begins postnatally, and its deletion attenuated CaMKII and Rac1 activity, reduced GluN1 glutamate receptor expression, and impaired synaptic plasticity and spatial learning and memory in 3-mo-old mice...
January 9, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28069442/novel-signaling-of-dynorphin-at-%C3%AE%C2%BA-opioid-receptor-bradykinin-b2-receptor-heterodimers
#10
Bingyuan Ji, Haiqing Liu, Rumin Zhang, Yunlu Jiang, Chunmei Wang, Sheng Li, Jing Chen, Bo Bai
The κ-opioid receptor (KOR) and bradykinin B2 receptor (B2R) are involved in a variety of important physiological processes and share many similar characteristics in terms of their distribution and functions in the nervous system. We first demonstrated the endogenous expression of KOR and B2R in human SH-SY5Y cells and their co-localization on the membrane of human embryonic kidney 293 (HEK293) cells. Bioluminescence and fluorescence resonance energy transfer and the proximity ligation assay were exploited to demonstrate the formation of functional KOR and B2R heteromers in transfected cells...
January 7, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28053034/simultaneous-loss-of-nckx4-and-cng-channel-desensitization-impairs-olfactory-sensitivity
#11
Christopher H Ferguson, Haiqing Zhao
: In vertebrate olfactory sensory neurons (OSNs), Ca(2+) plays key roles in both mediating and regulating the olfactory response. Ca(2+) enters OSN cilia during the response through the olfactory cyclic nucleotide-gated (CNG) channel and stimulates a depolarizing chloride current by opening the olfactory Ca(2+)-activated chloride channel to amplify the response. Ca(2+) also exerts negative regulation on the olfactory transduction cascade, through mechanisms that include reducing the CNG current by desensitizing the CNG channel via Ca(2+)/calmodulin (CaM), to reduce the response...
January 4, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28051848/one-step-assembly-of-molecular-separation-membranes-by-direct-atomizing-oligomer
#12
Hongwei Fan, Ren Wang, Linglong Shan, Hao Yan, Jie Li, Shulan Ji, Haiqing Lin, Guojun Zhang
Polymeric membranes are important materials for efficient sieving of targeted components at the molecular level, and have made significant advancement in many industrial applications such as biofuel production, water purification, fuel combustion and carbon dioxide capture. Although their separation efficiencies have been investigated enormously, lack of more efficient, greener and lower-cost membrane fabrication mechanisms is still a major hurdle for mass production, because the conventional membrane-making process is always time-consuming and highly inefficient, and simultaneously consumes a large amount of organic solvents...
January 4, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28045576/combination-therapy-with-l-arginine-and-%C3%AE-pd-l1-antibody-boosts-immune-response-against-osteosarcoma-in-immunocompetent-mice
#13
Xiaojun He, Haiqing Lin, Li Yuan, Binghao Li
L-arginine supplementation was recently proved to promote the function of immune cells, especially T-cells, by facilitating T-cell proliferation, differentiation and survival in vivo. Cytotoxic CD8(+) plays a crucial role in modulating anti-cancer response mediated by the immune system, but was restricted by exhaustion. Thus, we hypothesized that L-arginine, in combination with α-PD-L1 antibody, may provide a favored environment for T-cell response against osteosarcoma. Immunocompetent BALB/c mouse models bearing orthotopic and metastatic osteosarcoma were established to validate this conjecture...
January 3, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28045146/synthesis-driven-structure-dependent-optical-behavior-in-phase-tunable-nayf4-yb-er-based-motifs-and-associated-heterostructures
#14
Haiqing Liu, Jinkyu Han, Coray McBean, Crystal S Lewis, Prahlad Kumar Routh, Mircea Cotlet, Stanislaus S Wong
Understanding the key parameters necessary for generating uniform Er,Yb co-activated NaYF4 possessing various selected phases (i.e. cubic or hexagonal) represents an important chemical strategy towards tailoring optical behavior in these systems. Herein, we report on a straightforward hydrothermal synthesis in which the separate effects of reaction temperature, reaction time, and precursor stoichiometry in the absence of any surfactant were independently investigated. Interestingly, the presence and the concentration of NH4OH appear to be the most critical determinants of the phase and morphology...
January 18, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28044148/ar-p-bond-construction-by-the-pd-catalyzed-oxidative-cross-coupling-of-arylsilanes-with-h-phosphonates-via-c-si-bond-cleavage
#15
Haiqing Luo, Haidong Liu, Xingwei Chen, Keke Wang, Xuzhong Luo, Kejun Wang
A novel and efficient methodology that allows for the construction of Ar-P bonds via the Pd-catalyzed oxidative cross-coupling reaction of various arylsilanes with H-phosphonates leading to valuable arylphosphonates has been developed.
January 3, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28038942/novel-thrombopoietin-mimetic-peptides-bind-c-mpl-receptor-synthesis-biological-evaluation-and-molecular-modeling
#16
Yaquan Liu, Fang Tian, Dejuan Zhi, Haiqing Wang, Chunyan Zhao, Hongyu Li
Thrombopoietin (TPO) acts in promoting the proliferation of hematopoietic stem cells and by initiating specific maturation events in megakaryocytes. Now, TPO-mimetic peptides with amino acid sequences unrelated to TPO are of considerable pharmaceutical interest. In the present paper, four new TPO mimetic peptides that bind and activate c-Mpl receptor have been identified, synthesized and tested by Dual-Luciferase reporter gene assay for biological activities. The molecular modeling research was also approached to understand key molecular mechanisms and structural features responsible for peptide binding with c-Mpl receptor...
December 20, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28017227/comparison-of-stent-versus-medical-therapy-for-symptomatic-patients-with-intracranial-atherosclerotic-stenosis-a-meta-analysis
#17
Qian Zhang, Kai Dong, Haiqing Song
PURPOSE: To compare the outcomes of intracranial stent implantation and medical therapy for treatment of severe intracranial stenosis. METHODS: Articles were identified from Medline, Cochrane, EMBASE, and Google Scholar published up to August 25, 2016. Eligible studies reported stroke occurrence, transient ischemic attack (TIA), and event-free survival rates in patients who suffered recent TIA or stroke caused by stenosis of a major intracranial artery and treated with either medical therapy or stenting...
January 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27989107/atomic-h-induced-mo2c-hybrid-as-an-active-and-stable-bifunctional-electrocatalyst
#18
Xiujun Fan, Yuanyue Liu, Zhiwei Peng, Zhenhua Zhang, Haiqing Zhou, Xianming Zhang, Boris I Yakobson, William A Goddard, Xia Guo, Robert H Hauge, James M Tour
Mo2C nanocrystals (NCs) anchored on vertically aligned graphene nanoribbons (VA-GNR) as hybrid nanoelectrocatalysts (Mo2C-GNR) are synthesized through the direct carbonization of metallic Mo with atomic H treatment. The growth mechanism of Mo2C NCs with atomic H treatment is discussed. The Mo2C-GNR hybrid exhibits highly active and durable electrocatalytic performance for the hydrogen-evolution reaction (HER) and oxygen-reduction reaction (ORR). For HER, in an acidic solution the Mo2C-GNR has an onset potential of 39 mV and a Tafel slope of 65 mV dec(-1), and in a basic solution Mo2C-GNR has an onset potential of 53 mV, and Tafel slope of 54 mV dec(-1)...
January 3, 2017: ACS Nano
https://www.readbyqxmd.com/read/27979616/ocean-acidification-one-potential-driver-of-phosphorus-eutrophication
#19
Changzi Ge, Yanchao Chai, Haiqing Wang, Manman Kan
Harmful algal blooms which may be limited by phosphorus outbreak increases currently and ocean acidification worsens presently, which implies that ocean acidification might lead to phosphorus eutrophication. To verify the hypothesis, oxic sediments were exposed to seawater with different pH 30days. If pH was 8.1 and 7.7, the total phosphorus (TP) content in sediments was 1.52±0.50 and 1.29±0.40mg/g. The inorganic phosphorus (IP) content in sediments exposed to seawater with pH8.1 and 7.7 was 1.39±0.10 and 1...
December 12, 2016: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/27974198/proline-catabolism-modulates-innate-immunity-in-caenorhabditis-elegans
#20
Haiqing Tang, Shanshan Pang
Metabolic pathways are regulated to fuel or instruct the immune responses to pathogen threats. However, the regulatory roles for amino acid metabolism in innate immune responses remains poorly understood. Here, we report that mitochondrial proline catabolism modulates innate immunity in Caenorhabditis elegans. Modulation of proline catabolic enzymes affects host susceptibility to bacterial pathogen Pseudomonas aeruginosa. Mechanistically, proline catabolism governs reactive oxygen species (ROS) homeostasis and subsequent activation of SKN-1, a critical transcription factor regulating xenobiotic stress response and pathogen defense...
December 13, 2016: Cell Reports
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