keyword
MENU ▼
Read by QxMD icon Read
search

Haiqing

keyword
https://www.readbyqxmd.com/read/28436754/5-7-3-4-tetramethoxyflavone-protects-chondrocytes-from-er-stress-induced-apoptosis-through-regulation-of-the-ire1%C3%AE-pathway
#1
Longhuo Wu, Haiqing Liu, Linfu Li, Daohua Xu, Yun Gao, Yingjie Guan, Qian Chen
AIM OF THE STUDY: To investigate the roles of endoplasmic reticulum (ER) transmembrane sensor inositol-requiring enzyme-1 (IRE1)α signaling in ER stress-induced chondrocyte apoptosis, and to determine the molecular mechanisms underlying chondroprotective activity of 5,7,3',4'-tetramethoxyflavone (TMF) from Murraya Exotica. MATERIALS AND METHODS: IRE1α was knocked down by siRNA transfection in chondrocytes, which were harvested from rats' knee cartilages. Chondrocytes with IRE1α deficiency were administrated with tunicamycin (TM) and TMF...
April 24, 2017: Connective Tissue Research
https://www.readbyqxmd.com/read/28433419/disconnect-between-alcohol-induced-alterations-in-chromatin-structure-and-gene-transcription-in-a-mouse-embryonic-stem-cell-model-of-exposure
#2
Kylee J Veazey, Haiqing Wang, Yudhishtar S Bedi, William M Skiles, Richard Cheng-An Chang, Michael C Golding
Alterations to chromatin structure induced by environmental insults have become an attractive explanation for the persistence of exposure effects into subsequent life stages. However, a growing body of work examining the epigenetic impact that alcohol and other drugs of abuse exert consistently notes a disconnection between induced changes in chromatin structure and patterns of gene transcription. Thus, an important question is whether perturbations in the 'histone code' induced by prenatal exposures to alcohol implicitly subvert gene expression, or whether the hierarchy of cellular signaling networks driving development is such that they retain control over the transcriptional program...
January 11, 2017: Alcohol
https://www.readbyqxmd.com/read/28432511/environmental-management-zoning-for-coal-mining-in-mainland-china-based-on-ecological-and-resources-conditions
#3
Haiqing Geng, Fan Chen, Zhiyuan Wang, Jie Liu, Weihua Xu
The purpose of this research is to establish an environmental management zoning for coal mining industry which is served as a basis for making environmental management policies. Based on the specific impacts of coal mining and regional characteristics of environment and resources, the ecological impact, water resources impact, and arable land impact are chose as the zoning indexes to construct the index system. The ecological sensitivity is graded into three levels of low, medium, and high according to analytical hierarchy processes and gray fixed weight clustering analysis, and the water resources sensitivity is divided into five levels of lower, low, medium, high, and higher according to the weighted sum of sub-indexes, while only the arable land sensitive zone was extracted on the basis of the ratio of arable land to the county or city...
May 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28427346/karyotypic-evolution-of-the-medicago-complex-sativa-caerulea-falcata-inferred-from-comparative-cytogenetic-analysis
#4
Feng Yu, Haiqing Wang, Yanyan Zhao, Ruijuan Liu, Quanwen Dou, Jiangli Dong, Tao Wang
BACKGROUND: Polyploidy plays an important role in the adaptation and speciation of plants. The alteration of karyotype is a significant event during polyploidy formation. The Medicago sativa complex includes both diploid (2n = 2× = 16) and tetraploid (2n = 2× = 32) subspecies. The tetraploid M. ssp. sativa was regarded as having a simple autopolyploid origin from diploid ssp. caerulea, whereas the autopolyploid origin of tetraploid ssp. falcata from diploid form ssp. falcata is still in doubt...
April 21, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/28425486/lamin-b1-is-required-for-mature-neuron-specific-gene-expression-during-olfactory-sensory-neuron-differentiation
#5
Crystal M Gigante, Michele Dibattista, Frederick N Dong, Xiaobin Zheng, Sibiao Yue, Stephen G Young, Johannes Reisert, Yixian Zheng, Haiqing Zhao
B-type lamins are major constituents of the nuclear lamina in all metazoan cells, yet have specific roles in the development of certain cell types. Although they are speculated to regulate gene expression in developmental contexts, a direct link between B-type lamins and developmental gene expression in an in vivo system is currently lacking. Here, we identify lamin B1 as a key regulator of gene expression required for the formation of functional olfactory sensory neurons. By using targeted knockout in olfactory epithelial stem cells in adult mice, we show that lamin B1 deficient neurons exhibit attenuated response to odour stimulation...
April 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/28420985/mapping-dorsal-and-ventral-caudate-in-older-adults-method-and-validation
#6
Haiqing Huang, Peter T Nguyen, Nadine A Schwab, Jared J Tanner, Catherine C Price, Mingzhou Ding
The caudate nucleus plays important roles in cognition and affect. Depending on associated connectivity and function, the caudate can be further divided into dorsal and ventral aspects. Dorsal caudate, highly connected to dorsolateral prefrontal cortex (DLPFC), is implicated in executive function and working memory; ventral caudate, more interconnected with the limbic system, is implicated in affective functions such as pain processing. Clinically, certain brain disorders are known to differentially impact dorsal and ventral caudate...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28408942/identification-of-tengfu-jiangya-tablet-target-biomarkers-with-quantitative-proteomic-technique
#7
Jingwen Xu, Yunlun Li, Shijun Zhang, Haiqiang Jiang, Nan Wang, Haiqing Lin
Tengfu Jiangya Tablet (TJT) is a well accepted antihypertension drug in China and its major active components were Uncaria total alkaloids and Semen Raphani soluble alkaloid. To further explore treatment effects mechanism of TJT on essential hypertension, a serum proteomic study was performed. Potential biomarkers were quantified in serum of hypertension individuals before and after taking TJT with isobaric tags for relative and absolute quantitation (iTRAQ) coupled two-dimensional liquid chromatography followed electrospray ionization-tandem mass spectrometry (2D LC-MS/MS) proteomics technique...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28395219/synthesis-and-biological-evaluation-of-morpholine-substituted-diphenylpyrimidine-derivatives-mor-dppys-as-potent-egfr-t790m-inhibitors-with-improved-activity-toward-the-gefitinib-resistant-non-small-cell-lung-cancers-nsclc
#8
Zhendong Song, Shanshan Huang, Haiqing Yu, Yu Jiang, Changyuan Wang, Qiang Meng, Xiaohong Shu, Hunjun Sun, Kexin Liu, Yanxia Li, Xiaodong Ma
Potential new EGFR(T790M) inhibitors comprised of structurally modified diphenylpyrimidine derivatives bearing a morpholine functionality (Mor-DPPYs) were used to improve the activity and selectivity of gefitinib-resistant non-small cell lung cancer (NSCLC) treatment. This led to the identification of inhibitor 10c, which displayed high activity against EGFR(T790M/L858R) kinase (IC50 = 0.71 nM) and repressed H1975 cell replication harboring EGFR(T790M) mutations at a concentration of 0.037 μM. Inhibitor 10c demonstrated high selectivity (SI = 631...
April 2, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28385955/cyberbullying-perpetration-and-victimisation-among-junior-and-senior-high-school-students-in-guangzhou-china
#9
Jiaming Rao, Haiqing Wang, Minhui Pang, Jianwei Yang, Jiayi Zhang, Yunfeng Ye, Xiongfei Chen, Shengyong Wang, Xiaomei Dong
OBJECTIVES: Cyberbullying research in China is in early stage. This study describes the cyberbullying experiences of junior and senior high school students in Guangzhou, China, and to examine the risk factors associated with cyberbullying perpetrators, victims and perpetrator-victims among students. We also investigated the frequency of cyberbullying and coping strategies of student victims. METHODS: Participants were 2590 students in grades 7, 8, 9 and 10 from six junior and senior high schools in October 2015 in Guangzhou, in south China, who completed a questionnaire...
April 6, 2017: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/28371709/effect-of-filtration-mode-and-backwash-water-on-hydraulically-irreversible-fouling-of-ultrafiltration-membrane
#10
Haiqing Chang, Baicang Liu, Heng Liang, Huarong Yu, Senlin Shao, Guibai Li
To investigate the effect of filtration mode and backwash water on ultrafiltration (UF) membrane performance, total fouling index (TFI) and hydraulic irreversible fouling index (HIFI) for constant pressure (CP) filtration and constant flux (CF) filtration were compared. Kaolin, humic acid (HA) and sodium alginate (SA) solutions were used as feed solutions, and then the fouled membranes were backwashed with UF permeate or ultrapure water. Results showed that when the kaolin solution was filtrated, the filtration mode had a limited effect on the membrane fouling, and low TFI and HIFI were observed...
July 2017: Chemosphere
https://www.readbyqxmd.com/read/28356010/the-emerging-roles-of-rassf5-in-human-malignancy
#11
Shuofeng Li, Jingwei Teng, Haiqing Li, Junnian Zheng, Feifei Chen
Ras association domain family member 5 (RASSF5, also named NORE1) is an identified member of the RASSF gene family which could bind selectively to activated Ras and func¬tion as an antineoplastic effector in multiple cellular regulations. While high expressed in majority of normal tissues, RASSF5 is epigenetically inactivated by promoter hypermethylation in numerous cancer cell lines and primary cancers, suggesting it as a potential tumor suppressor. Nevertheless, the physiologic significance of RASSF5 in tumorigenesis remains unclear...
March 27, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28350089/mir%C3%A2-150-inhibits-proliferation-and-tumorigenicity-via-retarding-g1-s-phase-transition-in-nasopharyngeal-carcinoma
#12
Xiangyong Li, Fumei Liu, Bihua Lin, Haiqing Luo, Meilian Liu, Jinhua Wu, Caihong Li, Ronggang Li, Xin Zhang, Keyuan Zhou, Dong Ren
Cancer cells are characterized by a pathological manifestation of uncontrolled proliferation, which results in tumor formation. Therefore, it is necessary to improve understanding of the underlying mechanism of cell cycle control. Here, we report that miR‑150 is downregulated in nasopharyngeal carcinoma tissues and cells. Upregulation of miR‑150 suppresses nasopharyngeal carcinoma (NPC) cell proliferation and induces G1/S arrest in vitro, and inhibits tumorigenesis in vivo. Conversely, silencing miR‑150 yields the opposite effect...
March 10, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28341871/erratum-to-considering-total-intracranial-volume-and-other-nuisance-variables-in-brain-voxel-based-morphometry-in-idiopathic-pd
#13
Samuel Crowley, Haiqing Huang, Jared Tanner, Qing Zhao, Nadine A Schwab, Loren Hizel, Daniel Ramon, Babette Brumback, Mingzhou Ding, Catherine C Price
No abstract text is available yet for this article.
March 24, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28338541/intralesional-treatment-with-5-fluorouracil-and-steroid-improves-allergic-contact-dermatitis-without-causing-skin-atrophy-and-rebound-lesions
#14
Xiangming Chen, Guojiang Wang, Qingwen Zeng, Haiqing Zhang, Yang Hu, Aihua Yu, Ting Li
No abstract text is available yet for this article.
March 23, 2017: Dermatitis
https://www.readbyqxmd.com/read/28334358/ranges-of-cervical-intervertebral-disc-deformation-during-an-in-vivo-dynamic-flexion-extension-of-the-neck
#15
Yan Yu, Haiqing Mao, Jing-Sheng Li, Tsung-Yuan Tsai, Liming Cheng, Kirkham B Wood, Guoan Li, Thomas D Cha
While abnormal loading is widely believed to cause cervical spine disc diseases, in vivo cervical disc deformation during dynamic neck motion has not been well delineated. This study investigated the range of cervical disc deformation during an in vivo functional flexion-extension of the neck. Ten asymptomatic human subjects were tested using a combined dual fluoroscopic imaging system (DFIS) and magnetic resonance imaging (MRI)-based three-dimensional (3D) modeling technique. Overall disc deformation was determined using the changes of the space geometry between upper and lower endplates of each intervertebral segment (C3/4, C4/5, C5/6, and C6/7)...
June 1, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/28324950/a-preliminary-evaluation-of-myoelectrical-energy-distribution-of-the-front-neck-muscles-in-pharyngeal-phase-during-normal-swallowing
#16
Mingxing Zhu, Wanzhang Yang, Oluwarotimi Williams Samuel, Yun Xiang, Jianping Huang, Haiqing Zou, Guanglin Li
Pharyngeal phase is a central hub of swallowing in which food bolus pass through from the oral cavity to the esophageal. Proper understanding of the muscular activities in the pharyngeal phase is useful for assessing swallowing function and the occurrence of dysphagia in humans. In this study, high-density (HD) surface electromyography (sEMG) was used to study the muscular activities in the pharyngeal phase during swallowing tasks involving three healthy male subjects. The root mean square (RMS) of the HD sEMG data was computed by using a series of segmented windows as myoelectrical energy...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28302959/natural-history-of-mild-subclinical-hypothyroidism-in-a-middle-aged-and-elderly-chinese-population-a-prospective-study
#17
Xiang Li, Donghu Zhen, Meng Zhao, Lu Liu, Qingbo Guan, Haiqing Zhang, Shujian Ge, Xulei Tang, Ling Gao
Subclinical hypothyroidism (SCH) has a high global prevalence. Most SCH patients have mild cases (thyrotropin ≤10 mIU/L). Treatment recommendations for mild SCH are controversial, which raises concerns about the natural history of mild SCH. We aimed to clarify the natural history of mild SCH. This is a prospective population-based study. We measured thyroid function in 11,000 participants in the REACTION study and followed 505 newly diagnosed mild SCH patients aged 40-years or older between 2011 and 2014...
March 7, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28290536/corrigendum-evaluation-of-the-bone-ligament-and-tendon-insertions-based-on-raman-spectrum-and-its-pca-and-cls-analysis
#18
Yang Wu, Yu Dong, Jia Jiang, Haiqing Li, Tongming Zhu, Shiyi Chen
No abstract text is available yet for this article.
March 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28284341/mog-antibody-associated-demyelinating-disease-of-the-cns-a-clinical-and-pathological-study-in-chinese-han-patients
#19
Lei Zhou, Yongheng Huang, Haiqing Li, Jie Fan, Jingzi Zhangbao, Hai Yu, Yuxin Li, Jiahong Lu, Chongbo Zhao, Chuanzhen Lu, Min Wang, Chao Quan
We aim to evaluate the clinical relevance of MOG-ab in a cohort of Chinese Han adults with CNS inflammatory demyelinating diseases (IDDs). MOG-ab and AQP4-ab were examined through a fixed cell based indirect immune-fluorescence assay in 86 patients with CNS-IDDs. MOG-ab was positive in 12 patients, while AQP4-ab was positive in 31 patients; none double positives. Optic neuritis (ON) was the most frequent symptom at onset (75.0%) or during the whole disease course (83.3%) of MOG-ab associated IDDs (MOG-IDDs); 79...
April 15, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/28281580/association-of-scn10a-polymorphisms-with-the-recurrence-of-atrial-fibrillation-after-catheter-ablation-in-a-chinese-han-population
#20
Haiqing Wu, Juan Xu, Songwen Chen, Genqing Zhou, Baozhen Qi, Yong Wei, En Hu, Dongdong Tang, Gang Chen, Hongli Li, Liqun Zhao, Yongyong Shi, Shaowen Liu
The nonsynonymous SCN10A single nucleotide polymorphism (SNP) rs6795970 has been reported to associate with PR interval and atrial fibrillation (AF) and in strong linkage disequilibrium (LD) with the AF-associated SNP rs6800541. In this study, we investigated whether rs6795970 polymorphisms are associated with AF recurrence after catheter ablation. A total of 502 consecutive patients with AF who underwent catheter ablation were included. AF recurrence was defined as a documented episode of any atrial arrhythmias lasting ≥30 s after a blanking period of 3 months...
March 10, 2017: Scientific Reports
keyword
keyword
32524
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"