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JOURNAL ARTICLE
Jing-Jie Li, Xiao-Peng Wang, Xiang-Yang Bao, Qian-Nan Wang, Zi-Qing Kong, Qing-Bao Guo, Jia-Qi Liu, Gan Gao, Min-Jie Wang, Si-Meng Liu, He-Guan Fu, Huai-Yu Tong, Lian Duan
OBJECTIVE: The aim of this study was to develop and validate a predictive nomogram model for long-term rebleeding events in patients with hemorrhagic moyamoya disease (HMMD). METHODS: In total, 554 patients with HMMD from the Fifth Medical Center of the Chinese PLA General Hospital (5-PLAGH cohort) were included and randomly divided into training (390 patients) and internal validation (164 patients) sets. An independent cohort from the First Medical Center and Eighth Medical Center of Chinese PLA General Hospital (the 1-PLAGH and 8-PLAGH cohort) was used for external validation (133 patients)...
May 10, 2024: Journal of Neurosurgery
#2
JOURNAL ARTICLE
Chuang Wei, Yijun Gao, Peifeng Li
Glioma is a typical malignant tumor of the nervous system. It is of great significance to identify new biomarkers for accurate diagnosis of glioma. In this context, THOC6 has been studied as a highly diagnostic prognostic biomarker, which contributes to improve the dilemma in diagnosing gliomas. We used online databases and a variety of statistical methods, such as Wilcoxon rank sum test, Dunn test and t test. We analyzed the mutation, location and expression profile of THOC6, revealing the network of THOC6 interaction with disease...
May 10, 2024: Medicine (Baltimore)
#3
JOURNAL ARTICLE
Xiongyi Chen, Wenjing Liang, Xiaowen Wu, Yueying Wang, Yansui Hong, Meiyu Xie, Runkun Han, Zhifang Lin
Numerous inflammatory indicators have been demonstrated to be strongly correlated with tumor prognosis. However, the association between inflammatory indicators and the prognosis of patients with nasopharyngeal carcinoma (NPC) receiving treatment with programmed death receptor-1 (PD-1) immunosuppressant monoclonal antibodies remains uncertain. Inflammatory indicators in peripheral blood were collected from 161 NPC patients at 3 weeks after initial PD-1 treatment. Through univariate and multivariate analyses, as well as nomogram and survival analyses, we aimed to identify independent prognostic factors related to 1-year progression-free survival (PFS)...
May 10, 2024: Medicine (Baltimore)
#4
JOURNAL ARTICLE
Lihua Chen, Yu Zhao, Jingjing Qiu, Xiaosheng Lin
Postmenopausal osteoporosis (PMOP) is a common metabolic inflammatory disease. In conditions of estrogen deficiency, chronic activation of the immune system leads to a hypo-inflammatory phenotype and alterations in its cytokine and immune cell profile, although immune cells play an important role in the pathology of osteoporosis, studies on this have been rare. Therefore, it is important to investigate the role of immune cell-related genes in PMOP. PMOP-related datasets were downloaded from the Gene Expression Omnibus database...
May 10, 2024: Medicine (Baltimore)
#5
JOURNAL ARTICLE
Xiang Zhang, Chunzi Zhou, Jingwen Hu, Jingwen Hu, Yueping Ding, Shiqi Chen, Xu Wang, Lei Xu, Zhijun Gou, Shuqiao Zhang, Weiqun Shi
BACKGROUND: nonalcoholic fatty liver disease (NAFLD) is a common liver disease affecting the global population and its impact on human health will continue to increase. Genetic susceptibility is an important factor influencing its onset and progression, and there is a lack of reliable methods to predict the susceptibility of normal populations to NAFLD using appropriate genes. METHODS: RNA sequencing data relating to nonalcoholic fatty liver disease was analyzed using the "limma" package within the R software...
May 10, 2024: Medicine (Baltimore)
#6
JOURNAL ARTICLE
Zihan Zhu, Jing Lu
RNA editing, as an epigenetic mechanism, exhibits a strong correlation with the occurrence and development of cancers. Nevertheless, few studies have been conducted to investigate the impact of RNA editing on cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC). In order to study the connection between RNA editing and CESC patients' prognoses, we obtained CESC-related information from The Cancer Genome Atlas (TCGA) database and randomly allocated the patients into the training group or testing group...
May 10, 2024: Medicine (Baltimore)
#7
JOURNAL ARTICLE
Li Kun Huo, Kang Yin Chen, Gary Tse, Tong Liu
Inflammation contributes to the pathophysiological processes of coronary artery disease. We evaluated the association between inflammatory biomarkers, neutrophil-to-lymphocyte ratio (NLR), red cell distribution width (RDW), systemic inflammatory index, platelet-lymphocyte ratio, and 1-year all-cause mortality in patients underwent percutaneous coronary intervention (PCI). In this retrospective cohort, we consecutively enrolled 4651 patients who underwent PCI. Baseline demographic details, clinical data, and laboratory parameters on admission were analyzed...
May 10, 2024: Medicine (Baltimore)
#8
JOURNAL ARTICLE
Huajun Cai, Ye Wang, Shoufeng Li, Zhen Pan, Tianbao Xu, Yunjin Wang, Yiyi Zhang, Jinfu Zhuang, Xing Liu, Guoxian Guan
The aim was to assess conditional survival for colon mucinous adenocarcinoma (MAC) patients, and to construct nomograms to predict conditional survival probability. Survival analysis was done using conditional survival, which was defined as the probability of surviving additional y years for patients who have survived for x years. The mathematical definition was express as: CS (y|x) = S (x + y)/S (x). Cox regression analyses were used to identify prognostic factors. A nomogram is constructed to predict conditional disease-free survival (DFS) and overall survival (OS) probability according to years that already survive...
May 10, 2024: Updates in Surgery
#9
JOURNAL ARTICLE
Ting Liu, Guimei Wang, Chunmei Chen, Lihe He, Rensheng Wang
PURPOSE: Sarcopenia, characterized by loss of muscle mass index (SMI), serves as a diagnostic indicator for malnutrition and has been shown to influence cancer treatment outcomes. The objective of this study was to investigate the prognostic significance of sarcopenia on the locally advanced nasopharyngeal carcinoma (laNPC) patients. PATIENTS AND METHODS: 545 patients with stage III-IVa NPC were included in this retrospective study. Sarcopenia was defined using the skeletal muscle index (SMI) determined at the C3 level based on baseline MRI...
May 10, 2024: Japanese Journal of Radiology
#10
JOURNAL ARTICLE
Guangwei Zhang, Haoming Wang, Jianyang Hu, Chenyu Yang, Bingqian Tan, Jiqiang Hu, Mingman Zhang
BACKGROUND: Choledochal cyst with perforation (CC with perforation) rarely occurs, early diagnosis and timely treatment plan are crucial for the treatment of CC with perforation. This study aims to forecast the occurrence of CC with perforation. METHODS: All 1111 patients were conducted, who underwent surgery for choledochal cyst at our hospital from January 2011 to October 2022. We conducted univariate and multivariate logistic regression analysis to screen for independent predictive factors for predicting CC with perforation, upon which established a nomogram...
May 10, 2024: Pediatric Surgery International
#11
JOURNAL ARTICLE
Pengpeng Liu, Ping'an Ding, Honghai Guo, Jiaxuan Yang, Haotian Wu, Jiaxiang Wu, Peigang Yang, Qun Zhao
PURPOSE: Although microsatellite stability/Epithelial-mesenchymal transition (MSS/EMT) subtypes have been reported in multiple cancer prognosis studies, strong confounding factors between MSS/EMT (usually with Lauren's diffuse phenotype) and diffuse gastric cancer (GC) may obscure the independent prognostic value of diffuse GC. Additionally, recent studies suggest a strong correlation between mural stratification based on CT and diffuse GC. This study aims to investigate potential prognostic factors of MSS diffuse GC using mural stratification and to develop a risk assessment model...
May 10, 2024: Abdominal Radiology
#12
JOURNAL ARTICLE
Maria C Sighinolfi, Tommaso Calcagnile, Marco Ticonosco, Shaniko Kaleci, Stefano DI Bari, Simone Assumma, Luca Sarchi, Enrico Panio, Riccardo Ferrari, Adele Piro, Alberto Ragusa, Silvia Ciarlariello, Rodrigo D DA Silva, Roberto LA Rocca, Ester Illiano, Alessio Paladini, Francesco Persico, Davide Giraudo, Enrico DE Marzo, Riccardo Grisanti, Guglielmo Mantica, Esteban Emiliani, Massimo Madonia, Michele Salvetti, Pierfrancesco Bassi, Emanuele Montanari, Pierluigi Bove, Alchiede Simonato, Timothy D Averch, Francesco Porpiglia, Alessandro Calarco, Sebastiano Bruschetta, Fabio Manferrari, Francisco P Daels, Maria A Cerruto, Alessandro Antonelli, Giorgio Mazzon, Antonio Celia, Claudio Simeone, Stefano Zaramella, Alberto Saita, Elisabetta Costantini, Ettore Mearini, Mauro DE Dominicis, Vincenzo Mirone, Fernando J Kim, Stefania Ferretti, Stefano Puliatti, Bernardo Rocco, Salvatore Micali
BACKGROUND: Stone nomogram by Micali et al., able topredict treatment failure of shock-wave lithotripsy (SWL), retrograde intrarenal surgery (RIRS) and percutaneous nephrolithotomy (PNL) in the management of single 1-2 cm renal stones, was developed on 2605 patients and showed a high predictive accuracy, with an area under ROC curve of 0.793 at internal validation. The aim of the present study is to externally validate the model to assess whether it displayed a satisfactory predictive performance if applied to different populations...
May 10, 2024: Minerva urology and nephrology
#13
JOURNAL ARTICLE
Zhen-Ni Guo, Yang Qu, Zi-Duo Shen, Jia Liu, Zhong-Xiu Wang, Ying-Ying Sun, Ke-Jia Zhang, Junlei Chang, Xiang-Kun Si, Hang Jin, Xin Sun, Yi Yang
AIMS: To investigate the characteristics of dynamic cerebral autoregulation (dCA) after intravenous thrombolysis (IVT) and assess the relationship between dCA and prognosis. METHODS: Patients with unilateral acute ischemic stroke receiving IVT were prospectively enrolled; those who did not were selected as controls. All patients underwent dCA measurements, by quantifying the phase difference (PD) and gain, at 1-3 and 7-10 days after stroke onset. Simultaneously, two dCA-based nomogram models were established to verify the predictive value of dCA for patients with mild-to-moderate stroke...
May 2024: CNS Neuroscience & Therapeutics
#14
REVIEW
D Y Chow, J R H Tay, G G Nascimento
This study reviews and appraises the methodological and reporting quality of prediction models for tooth loss in periodontitis patients, including the use of regression and machine learning models. Studies involving prediction modeling for tooth loss in periodontitis patients were screened. A search was performed in MEDLINE via PubMed, Embase, and CENTRAL up to 12 February 2022, with citation chasing. Studies exploring model development or external validation studies for models assessing tooth loss in periodontitis patients for clinical use at any time point, with all prediction horizons in English, were considered...
May 10, 2024: Journal of Dental Research
#15
JOURNAL ARTICLE
Alessandra Borghi, Alessandro Gronchi
PURPOSE OF REVIEW: Prognostication of soft tissue sarcomas is challenging due to the diversity of prognostic factors, compounded by the rarity of these tumors. Nomograms are useful predictive tools that assess multiple variables simultaneously, providing estimates of individual likelihoods of specific outcomes at defined time points. Although these models show promising predictive ability, their use underscores the need for further methodological refinement to address gaps in prognosis accuracy...
May 1, 2024: Current Opinion in Oncology
#16
JOURNAL ARTICLE
Jinyu Hu, Qinxuan Xu, Yuchang Fei, Zhengwei Tan, Lei Pan
Gastric Cancer (GC) has become one of the most important causes of cancer-related deaths worldwide due to its intractability. Studying the mechanisms of gastric carcinogenesis, recurrence, and metastasis, and searching for new therapeutic targets have become the main directions of today's gastric cancer research. Lactate is considered a metabolic by-product of tumor aerobic glycolysis, which can regulate tumor development through various mechanisms, including cell cycle regulation, immunosuppression, and energy metabolism...
May 9, 2024: Current Molecular Medicine
#17
JOURNAL ARTICLE
Xinghao Ma, Xiumin Lu, Xiaoyang Jiang, Jiajia Wang, Tingting Wang, Li Zhang
INTRODUCTION: the prognostic nutritional index (PNI) and platelet-lymphocyte ratio (PLR) have been found to correlate with outcomes following radical gastrectomy for gastric cancer (GC). OBJECTIVES: to construct a nomogram combining PNI and PLR for individually forecasting the risk of postoperative pulmonary infection (POI) following D2 radical gastrectomy for GC. METHODS: retrospectively, clinical data was gathered from 404 patients treated with D2 radical gastrectomy for GC...
April 26, 2024: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
#18
JOURNAL ARTICLE
Jinjing Guo, Zhibing Jiang, Yiping Xia, Hui Wang, Qun Tang, Bin Meng
BACKGROUND: A serious consequence of diabetes is diabetic nephropathy (DN), which is commonly treated by statins. Studies evaluating the effects of statin medication have yielded inconsistent results regarding the potential association with diabetic nephropathy. To manage diabetic nephropathy's onset and improve the quality of life of patients, it is imperative to gain a comprehensive understanding of its contributing factors. DATA AND METHODS: Our study was conducted using the National Health and Nutrition Examination Survey (NHANES) as well as weighted multivariate logistic regression models to determine the odds ratio (OR) and 95% confidence intervals (95%CI) for diabetic nephropathy...
2024: Frontiers in Endocrinology
#19
JOURNAL ARTICLE
Yunyang Wu, Shenhui Yin, Chunzhen Li, Liyuan Zhao, Mengqi Song, Yizhi Yu, Ling Tang, Yanlong Yang
Melanoma is the most aggressive type of skin cancer and has a high mortality rate once metastasis occurs. Hypoxia is a universal characteristic of the microenvironment of cancer and a driver of melanoma progression. In recent years, long noncoding RNAs (lncRNAs) have attracted widespread attention in oncology research. In this study, screening was performed and revealed seven hypoxia-related lncRNAs AC008687.3, AC009495.1, AC245128.3, AL512363.1, LINC00518, LINC02416 and MCCC1-AS1 as predictive biomarkers. A predictive risk model was constructed via univariate Cox regression analysis, least absolute shrinkage and selection operator (LASSO), and multivariate Cox regression analyses...
2024: American Journal of Cancer Research
#20
JOURNAL ARTICLE
Chenxi Liu, Liqiang Zhou, Zhiqing Chen
The aim of the present study was to investigate the function of 29 E26 (ETS) transcription factor families in gastric cancer (GC) and determine their association with prognosis. Our analysis of the expression of the ETS family revealed that 28 genes were dysregulated in GC, and that their expression was associated with multiple clinicopathological features (P<0.05). Based on the expression signature of the ETS family, consensus clustering was performed to generate two gastric cancer subtypes. These subtypes exhibited differences in overall survival (OS, P = 0...
2024: American Journal of Cancer Research
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