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https://www.readbyqxmd.com/read/27936474/-three-years-follow-up-study-after-refractive-small-incision-lenticule-extraction-smile-using-500%C3%A2-khz-femtosecond-laser-in-fast-mode
#1
A Messerschmidt-Roth, W Sekundo, A Lazaridis, S Schulze
Background: The aim of this clinical trial was to check the results of laser built-in settings 3 years after ReLEx SMILE for moderate and high myopia in unselected "real life" patients. Patients and Methods: 50 myopic eyes of 27 patients were called in for examination after 3 years. 25 of these eyes with a preoperative myopia under - 6D comprised the "moderate myopia subgroup". All surgeries were performed with the 500 kHz VisuMax® femtosecond laser (Carl Zeiss Meditec AG, Jena) in the "fast mode" setting...
December 9, 2016: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/27931238/elaboration-of-a-nomogram-to-predict-nonsentinel-node-status-in-breast-cancer-patients-with-positive-sentinel-node-intraoperatively-assessed-with-one-step-nucleic-amplification-retrospective-and-validation-phase
#2
Franco Di Filippo, Simona Di Filippo, Anna Maria Ferrari, Raffaele Antonetti, Alessandro Battaglia, Francesca Becherini, Laia Bernet, Renzo Boldorini, Catherine Bouteille, Simonetta Buglioni, Paolo Burelli, Rafael Cano, Vincenzo Canzonieri, Pierluigi Chiodera, Alfredo Cirilli, Luigi Coppola, Stefano Drago, Luca Di Tommaso, Privato Fenaroli, Roberto Franchini, Andrea Gianatti, Diana Giannarelli, Carmela Giardina, Florence Godey, Massimo M Grassi, Giuseppe B Grassi, Siobhan Laws, Samuele Massarut, Giuseppe Naccarato, Maria Iole Natalicchio, Sergio Orefice, Fabrizio Palmieri, Tiziana Perin, Manuela Roncella, Massimo G Roncalli, Antonio Rulli, Angelo Sidoni, Corrado Tinterri, Maria C Truglia, Isabella Sperduti
BACKGROUND: Tumor-positive sentinel lymph node (SLN) biopsy results in a risk of non sentinel node metastases in micro- and macro-metastases ranging from 20 to 50%, respectively. Therefore, most patients underwent unnecessary axillary lymph node dissections. We have previously developed a mathematical model for predicting patient-specific risk of non sentinel node (NSN) metastases based on 2460 patients. The study reports the results of the validation phase where a total of 1945 patients were enrolled, aimed at identifying a tool that gives the possibility to the surgeon to choose intraoperatively whether to perform or not axillary lymph node dissection (ALND)...
December 8, 2016: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/27930844/development-and-external-validation-of-a-biopsy-derived-nomogram-to-predict-risk-of-ipsilateral-extraprostatic-extension
#3
Rashid Sayyid, Nathan Perlis, Ardalanejaz Ahmad, Andrew Evans, Ants Toi, Michael Horrigan, Antonio Finelli, Alexandre Zlotta, Girish Kulkarni, Robert Hamilton, Christopher Morash, Neil Fleshner
OBJECTIVES: To develop and externally validate a nomogram that predicts risk of side-specific EPE at time of surgery, using commonly available pre-operative markers. MATERIALS AND METHODS: A consecutive sample of 753 men treated by radical prostatectomy at University Health Network, between 2009 and 2015, was used to develop the nomogram. The validation cohort consisted of 311 men treated by radical prostatectomy at Ottawa Hospital Research Institute, between 1992 and 2014...
December 8, 2016: BJU International
https://www.readbyqxmd.com/read/27927860/prediction-of-outcome-from-adult-bacterial-meningitis-in-a-high-hiv-seroprevalence-resource-poor-setting-using-the-malawi-adult-meningitis-score-mams
#4
Emma C Wall, Mavuto Mukaka, Matthew Scarborough, Katherine Ma Ajdukiewicz, Katharine E Cartwright, Mulinda Nyirenda, Brigitte Denis, Theresa J Allain, Brian Faragher, David G Lalloo, Robert S Heyderman
: Acute bacterial meningitis (ABM) in adults residing in resource-poor countries is associated with mortality rates in excess of 50%. To improve outcome, interventional trials and standardised clinical algorithms are urgently required. To optimise these processes we developed and validated an outcome prediction tool to identify ABM patients at greatest risk of death. METHODS: We derived a nomogram using mortality predictors derived from a logistic regression model of a discovery database of adult Malawian ABM patients (n=523, 65% CSF culture positive)...
December 7, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27923290/computerised-analysis-of-antepartum-foetal-heart-parameters-new-reference-ranges
#5
Natascia Giuliano, Maria Laura Annunziata, Francesca Giovanna Esposito, Salvatore Tagliaferri, Andrea Di Lieto, Giovanni Magenes, Maria Gabriella Signorini, Marta Campanile, Domenico Arduini
We selected 4012 cCTG records (one trace for each patient) performed in healthy pregnancies from 30th to 42nd gestational week using foetal heart rate (FHR), short-term variability (STV), long-term irregularity (LTI), Delta, approximate entropy (ApEn), spectral components as low frequency (LF), median frequency (MF), high frequency (HF) and LF/(HF + MF) ratio were analysed. Reference nomograms were created and sensitivity and specificity for the prediction of foetal compromise were calculated which were 90% and 89%, respectively...
December 6, 2016: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27919990/validation-and-enhancement-of-the-clinicopathological-melanoma-nomogram-via-incorporation-of-a-molecular-marker-in-the-primary-tumor
#6
Samer A Naffouje, Rand Naffouje, Jinsong Chen, George I Salti
BACKGROUND/AIM: To validate the melanoma nomogram and improve its function in prediction of nodal dissemination by incorporating a molecular marker in the model. Microphthalmia transcription factor (MITF) is an important regulator of melanocyte homeostasis and differentiation. We have shown that the grade of MITF expression in primary melanoma cells can serve as a predictor of nodal status. Many efforts to identify the nodal spread in cutaneous melanoma using non-invasive means have been recently undertaken...
December 2016: Anticancer Research
https://www.readbyqxmd.com/read/27919349/familial-combined-hyperlipidemia-and-hyperlipoprotein-a-as-phenotypic-mimics-of-familial-hypercholesterolemia-frequencies-associations-and-predictions
#7
Katrina L Ellis, Jing Pang, Dick C Chan, Amanda J Hooper, Damon A Bell, John R Burnett, Gerald F Watts
BACKGROUND: A significant proportion of index cases presenting with phenotypic familial hypercholesterolemia (FH) are not found to have a pathogenic mutation and may have other inherited conditions. OBJECTIVES: Familial combined hyperlipidemia (FCHL) and elevated lipoprotein(a) [Lp(a)] may mimic FH, but the frequency and correlates of these disorders among mutation-negative FH patients have yet to be established. METHODS: The frequency of FCHL and elevated Lp(a) was investigated in 206 FH mutation-negative index cases attending a specialist lipid clinic...
November 2016: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/27917904/glycoprotein-130-is-associated-with-adverse-postoperative-clinical-outcomes-of-patients-with-late-stage-non-metastatic-gastric-cancer
#8
Yifan Cao, Heng Zhang, Hao Liu, Chao Lin, Ruochen Li, Songyang Wu, Hongyong He, He Li, Jiejie Xu
The interaction of glycoprotein 130 (gp130) with the cytokines of Interleukin-6 (IL-6) family has proved to play a crucial part in several cancers. Our current study is designed to discover the clinical prognostic significance of gp130 in non-metastatic gastric cancer. We examined intratumoral gp130 expression in retrospectively enrolled 370 gastric cancer patients who underwent radical gastrectomy with standard D2 lymphadenectomy at Zhongshan Hospital of Fudan University during 2007 and 2008 by immunohistochemical staining...
December 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27916194/standard-outcome-indicators-after-colon-cancer-resection-creation-of-a-nomogram-for-autoevaluation
#9
Jorge Sancho-Muriel, Matteo Frasson, David Hervás, Blas Flor-Lorente, José Luis Ramos Rodriguez, Manuel Romero Simó, Jordi Escoll Rufino, Marta Santamaría Olabarrieta, José Viñas Martinez, Manolo López Bañeres, Eduardo García-Granero
INTRODUCTION: Lately there has been an increasing interest in identifying quality standards in different pathologies, among them colon cancer due to its great prevalence. The main goal of this study is to define the quality standards of colon cancer surgery based on a large prospective national study dataset. METHODS: Data from the prospective national study ANACO were used. This study included a consecutive series of patients operated on for colon cancer in 52 Spanish hospitals (2011-2012)...
December 1, 2016: Cirugía Española
https://www.readbyqxmd.com/read/27912898/a-clinical-prediction-model-for-prolonged-air-leak-after-pulmonary-resection
#10
Adam Attaar, Daniel G Winger, James D Luketich, Matthew J Schuchert, Inderpal S Sarkaria, Neil A Christie, Katie S Nason
OBJECTIVE: Prolonged air leak increases costs and worsens outcomes after pulmonary resection. We aimed to develop a clinical prediction tool for prolonged air leak using pretreatment and intraoperative variables. METHODS: Patients who underwent pulmonary resection for lung cancer/nodules (from January 2009 to June 2014) were stratified by prolonged parenchymal air leak (>5 days). Using backward stepwise logistic regression with bootstrap resampling for internal validation, candidate variables were identified and a nomogram risk calculator was developed...
October 14, 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27911274/high-expression-of-mucin13-associates-with-grimmer-postoperative-prognosis-of-patients-with-non-metastatic-clear-cell-renal-cell-carcinoma
#11
Zhiying Xu, Yidong Liu, Yuanfeng Yang, Jieti Wang, Guodong Zhang, Zheng Liu, Hangcheng Fu, Zewei Wang, Haiou Liu, Jiejie Xu
BACKGROUND: Mucin13 (MUC13) is a transmembrane glycoprotein that is aberrantly expressed in ovarian and gastro-intestinal tumors, but its role in renal cell carcinoma remains elusive. The purpose of this study is to evaluate the prognostic value of MUC13 expression in patients with non-metastatic clear cell renal cell carcinoma (ccRCC) after surgical resection. RESULTS: MUC13 high expression was associated with high Fuhrman grade (p < 0.001), high SSIGN score (p = 0...
November 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/27898745/-internet-based-opportunities-in-breast-cancer-diagnostics-and-research
#12
Ádám Nagy, Balázs Gyõrffy
A new generation of internet-based diagnostic and research tools have arrived in the last decade. The most extensive group of these includes programs predicting the expected survival mainly by utilizing clinical data of the patient. This includes Adjuvant! Online, the MSKCC and MD Anderson nomograms and the UK-based PREDICT algorithm. A common feature of all these is the comparison of the given patient to previously treated breast cancer samples, and evaluating the clinical outcome of these previous patients...
November 29, 2016: Magyar Onkologia
https://www.readbyqxmd.com/read/27890682/implementation-of-dynamically-updated-prediction-models-at-the-point-of-care-at-a-major-cancer-center-making-nomograms-more-like-netflix
#13
Andrew J Vickers, Mathew Kent, Peter T Scardino
No abstract text is available yet for this article.
November 24, 2016: Urology
https://www.readbyqxmd.com/read/27889982/external-validation-and-evaluation-of-reliability-and-validity-of-the-triple-d-score-to-predict-stone-free-status-after-shock-wave-lithotripsy
#14
Faruk Ozgor, Muhammed Tosun, Yunus Kayali, Metin Savun, Murat Binbay, Abdulkadir Tepeler
OBJECTIVE: The Triple D scoring system is defined as novel and simple nomogram using the main parameters (skin-to-stone distance, stone density, and volume) in order to indicate most appropriate patients for shock-wave lithotripsy (SWL). We aimed to evaluate the accuracy of the Triple D scoring system in predicting SWL success rates. PATIENTS AND METHODS: In two tertiary academic centers, charts were retrospectively analyzed of patients who had, between January 2014 and May 2016, been treated by SWL for radiopaque kidney stones...
November 27, 2016: Journal of Endourology
https://www.readbyqxmd.com/read/27887636/development-and-validation-of-a-nomogram-for-predicting-the-survival-of-patients-with-non-metastatic-nasopharyngeal-carcinoma-after-curative-treatment
#15
Wenhua Liang, Guanzhu Shen, Yaxiong Zhang, Gang Chen, Xuan Wu, Yang Li, Anchuan Li, Shiyang Kang, Xi Yuan, Xue Hou, Peiyu Huang, Yan Huang, Hongyun Zhao, Ying Tian, Chong Zhao, Li Zhang
BACKGROUND: The TNM staging system is far from perfect in predicting the survival of individual cancer patients because only the gross anatomy is considered. The survival rates of the patients who have the same TNM stage disease vary across a wide spectrum. This study aimed to develop a nomogram that incorporates other clinicopathologic factors for predicting the overall survival (OS) of non-metastatic nasopharyngeal carcinoma (NPC) patients after curative treatments. METHODS: We retrospectively collected the clinical data of 1520 NPC patients who were diagnosed histologically between November 2000 and September 2003...
November 25, 2016: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/27886686/preoperative-versus-postoperative-initiation-of-warfarin-therapy-in-patients-undergoing-total-hip-and-knee-arthroplasty
#16
REVIEW
Cara Cipriano, Nicholas Erdle, Kai Li, Brian Curtin
The optimal strategy for postoperative deep venous thrombosis prophylaxis remains controversial in hip and knee arthroplasty. Warfarin causes transient hypercoagulability; however, the optimal timing of treatment remains unclear. We evaluated the effects of preoperative versus postoperative warfarin therapy with a primary endpoint of perioperative change in hemoglobin. Warfarin was dosed according to a standard nomogram. No difference in perioperative hemoglobin change was observed. The preoperative group demonstrated higher INRs...
January 2017: Orthopedic Clinics of North America
https://www.readbyqxmd.com/read/27885853/nomogram-for-radiation-induced-hypothyroidism-prediction-in-nasopharyngeal-carcinoma-after-treatment
#17
Ren Luo, Mei Li, Zhining Yang, Yizhou Zhan, Baotian Huang, Jiayang Lu, Zhenxi Xu, Zhixiong Lin
OBJECTIVE: The aim of this study was to develop a nomogram for radiation-induced hypothyroidism (RHT) prediction. METHODS: We collected data from 164 NPC patients in our previous prospective study. Biochemical hypothyroidism (HT) was defined as a serum thyroid stimulating hormone (TSH) level greater than the normal value. We collected both clinical and dose-volume factors. A univariate Cox regression analysis was performed to identify RHT risk factors. Optimal predictors were selected according to the least absolute shrinkage and selection operator (LASSO)...
November 25, 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27885441/bayesian-comparative-assessment-of-diagnostic-accuracy-of-low-dose-ct-scan-and-ultrasonography-in-the-diagnosis-of-urolithiasis-after-the-application-of-the-stone-score
#18
Laila Cochon, Jeffrey Smith, Amado Alejandro Baez
OBJECTIVE: The objective of our study was to assess the diagnostic quality of low-dose computed tomography (CT) when compared to ultrasound (US) in diagnosis of urolithiasis using STONE score as a predictor of pre-test probability and the Bayesian statistical model to calculate post-test probabilities (POST) for both diagnostic tests. METHODS: STONE score was used to form risk groups to obtain pre-test probabilities. Likelihood ratios (LR) were calculated from external data for low-dose CT and US...
November 25, 2016: Emergency Radiology
https://www.readbyqxmd.com/read/27885062/quantifying-risk-of-early-relapse-in-patients-with-first-demyelinating-events-prediction-in-clinical-practice
#19
Tim Spelman, Claire Meyniel, Juan Ignacio Rojas, Alessandra Lugaresi, Guillermo Izquierdo, Francois Grand'Maison, Cavit Boz, Raed Alroughani, Eva Havrdova, Dana Horakova, Gerardo Iuliano, Pierre Duquette, Murat Terzi, Pierre Grammond, Raymond Hupperts, Jeannette Lechner-Scott, Celia Oreja-Guevara, Eugenio Pucci, Freek Verheul, Marcela Fiol, Vincent Van Pesch, Edgardo Cristiano, Thor Petersen, Fraser Moore, Tomas Kalincik, Vilija Jokubaitis, Maria Trojano, Helmut Butzkueven
BACKGROUND: Characteristics at clinically isolated syndrome (CIS) examination assist in identification of patient at highest risk of early second attack and could benefit the most from early disease-modifying drugs (DMDs). OBJECTIVE: To examine determinants of second attack and validate a prognostic nomogram for individualised risk assessment of clinical conversion. METHODS: Patients with CIS were prospectively followed up in the MSBase Incident Study...
November 24, 2016: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/27875859/clinical-significance-of-preoperative-renal-function-and-gross-hematuria-for-intravesical-recurrence-after-radical-nephroureterectomy-for-upper-tract-urothelial-carcinoma
#20
Takeshi Hashimoto, Jun Nakashima, Takeshi Kashima, Yosuke Hirasawa, Kenji Shimodaira, Tatsuo Gondo, Yoshihiro Nakagami, Kazunori Namiki, Yutaka Horiguchi, Yoshio Ohno, Makoto Ohori, Masaaki Tachibana
OBJECTIVES: To investigate the predictive values of perioperative factors and to develop a nomogram for intravesical recurrence after radical nephroureterectomy in patients with upper urinary tract urothelial carcinoma. METHODS: A retrospective analysis of 144 patients who underwent radical nephroureterectomy from 1996 to 2014 was carried out. The actuarial probabilities of the intravesical recurrence-free survival rate were calculated using the Kaplan-Meier method...
November 22, 2016: International Journal of Urology: Official Journal of the Japanese Urological Association
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