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https://www.readbyqxmd.com/read/28446011/development-of-decision-support-formulas-for-the-prediction-of-bladder-outlet-obstruction-and-prostatic-surgery-in-patients-with-lower-urinary-tract-symptom-benign-prostatic-hyperplasia-part-ii-external-validation-and-usability-testing-of-a-smartphone-app
#1
Min Soo Choo, Seong Jin Jeong, Sung Yong Cho, Changwon Yoo, Chang Wook Jeong, Ja Hyeon Ku, Seung-June Oh
PURPOSE: We aimed to externally validate the prediction model we developed for having bladder outlet obstruction (BOO) and requiring prostatic surgery using 2 independent data sets from tertiary referral centers, and also aimed to validate a mobile app for using this model through usability testing. METHODS: Formulas and nomograms predicting whether a subject has BOO and needs prostatic surgery were validated with an external validation cohort from Seoul National University Bundang Hospital and Seoul Metropolitan Government-Seoul National University Boramae Medical Center between January 2004 and April 2015...
April 2017: International Neurourology Journal
https://www.readbyqxmd.com/read/28446010/development-of-decision-support-formulas-for-the-prediction-of-bladder-outlet-obstruction-and-prostatic-surgery-in-patients-with-lower-urinary-tract-symptom-benign-prostatic-hyperplasia-part-i-development-of-the-formula-and-its-internal-validation
#2
Min Soo Choo, Changwon Yoo, Sung Yong Cho, Seong Jin Jeong, Chang Wook Jeong, Ja Hyeon Ku, Seung-June Oh
PURPOSE: As the elderly population increases, a growing number of patients have lower urinary tract symptom (LUTS)/benign prostatic hyperplasia (BPH). The aim of this study was to develop decision support formulas and nomograms for the prediction of bladder outlet obstruction (BOO) and for BOO-related surgical decision-making, and to validate them in patients with LUTS/BPH. METHODS: Patient with LUTS/BPH between October 2004 and May 2014 were enrolled as a development cohort...
April 2017: International Neurourology Journal
https://www.readbyqxmd.com/read/28443676/pre-operative-nomograms-for-predicting-renal-function-at-1-year-after-partial-nephrectomy
#3
Cheuk Fan Shum, Clinton D Bahler, Clint Cary, Timothy A Masterson, Ronald S Boris, Thomas A Gardner, Hristos Z Kaimakliotis, Rick Foster, Richard Bihrle, Michael Koch, James E Slaven, Chandru P Sundaram
INTRODUCTION: Partial nephrectomy (PN) reduces the risk of post-operative chronic renal insufficiency (CRI). However, some patients still develop CRI after PN, and may eventually require dialysis. Being able to predict renal function before PN helps in counseling patients and managing expectations. We aimed to construct nomograms that predict estimated glomerular filtration rate (eGFR), defined by the Modification of Diet in Renal Disease (MDRD) and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formulae, at one year after PN, using only pre-operative covariates as predictors...
April 26, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28438885/prognostic-nomograms-stratify-survival-of-patients-with-hepatocellular-carcinoma-without-portal-vein-tumor-thrombosis-after-curative-resection
#4
Yi-Peng Fu, Yong Yi, Jin-Long Huang, Chu-Yu Jing, Jian Sun, Xiao-Chun Ni, Zhu-Feng Lu, Ya Cao, Jian Zhou, Jia Fan, Shuang-Jian Qiu
BACKGROUND: The prognosis of patients with hepatocellular carcinoma (HCC) without portal vein tumor thrombosis (PVTT) after curative resection is at variance. We identified the risk factors of poor postoperative prognosis and consequently developed prognostic nomograms generating individual risk of death and recurrence for this subgroup of patients with HCC. METHODS: The risk factors were identified and nomograms were developed based on a retrospective study of 734 patients in the primary cohort who underwent curative resection for HCC from 2010 to 2012...
April 24, 2017: Oncologist
https://www.readbyqxmd.com/read/28435823/blood-pressure-nomograms-for-children-and-adolescents-by-age-and-body-mass-index-in-tehran-iran
#5
Neamatollah Ataei, Masoud Baikpour, Mostafa Hosseini, Mahmoud Yousefifard, Mohammad Fayaz, Fatemeh Ataei, Arash Abbasi
BACKGROUND: Normal standard references of blood pressure (BP) for children and adolescents should be constructed according to anthropometric indices. Therefore, we aimed to produce BP reference percentiles by body mass index (BMI). METHODS: Data on demographic characteristics, anthropometric indices and BP values of 16246 3-18-year-old children and adolescents from 3 cross-sectional studies conducted in Tehran were included. To justify the need for BMI adjustment, quantile regression model was applied for different percentiles of systolic and diastolic BPs with age, sex, and the corresponding BMI percentiles...
March 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28433249/multicenter-analysis-of-impact-of-anastomotic-leakage-on-long-term-oncologic-outcomes-after-curative-resection-of-colon-cancer
#6
Saori Goto, Suguru Hasegawa, Koya Hida, Ryuji Uozumi, Yukihide Kanemitsu, Toshiaki Watanabe, Kenichi Sugihara, Yoshiharu Sakai
BACKGROUND: In rectal cancer, anastomotic leakage was reported to have a negative impact on both short- and long-term outcomes. However, there is limited data on the impact of anastomotic leakage on oncologic outcomes in patients with colon cancer. We aimed to evaluate the impact of anastomotic leakage on disease recurrence and long-term survival after curative resection of colon cancer. METHODS: This multicenter, retrospective cohort study of 4,919 consecutive patients utilized data from the Japanese Society for Cancer of the Colon and Rectum...
April 19, 2017: Surgery
https://www.readbyqxmd.com/read/28433235/-stone-free-rate-assesment-after-percutaneous-nephrolithotomy-using-nephrolitometric-nomogram
#7
Jason Damián Landa-Salas, Juan Ramón Torres-Anguiano, Efraín Maldonado-Alcaraz, Virgilio Augusto Lopez-Samano, Eduardo Alonso Serrano-Brambila, Jorge Moreno-Palacios
BACKGROUND: Percutaneous nephrolithotomy remains the standard of care for kidney stones larger than 2cm. Therefore, setting a prognosis for complete stone resolution through this method is essential. The prognostic tools available have limited prediction. OBJECTIVES: To evaluate the stone-free rate in patients undergoing percutaneous nephrolithotomy with the Clinical Research Office of the Endourological Society nomogram and suggest modifications to improve the classification...
April 19, 2017: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/28430613/development-of-comprehensive-nomograms-for-evaluating-overall-and-cancer-specific-survival-of-laryngeal-squamous-cell-carcinoma-patients-treated-with-neck-dissection
#8
Xiao Shi, Wei-Ping Hu, Qing-Hai Ji
BACKGROUND: Neck dissection for laryngeal squamous cell carcinoma (LSCC) patients could provide complementary prognostic information for AJCC N staging, like lymph node ratio (LNR). The aim of this study was to develop effective nomograms to better predict survival for LSCC patients treated with neck dissection. RESULTS: 2752 patients were identified and randomly divided into training (n = 2477) and validation (n = 275) cohorts. The 3- and 5-year probabilities of cancer-specific mortality (CSM) were 30...
February 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28429830/establishment-and-evaluation-of-a-novel-biomarker-based-nomogram-for-malignant-phaeochromocytomas-and-paragangliomas
#9
Xu Zhong, Lei Ye, TingWei Su, Jing Xie, Weiwei Zhou, Yiran Jiang, Lei Jiang, Guang Ning, Weiqing Wang
OBJECTIVE: No single histological or molecular marker is diagnostic for malignant phaeochromocytomas and paragangliomas (PPGLs). This study aimed to establish and evaluate a prognostic nomogram to improve the prediction of metastatic probability in individual PPGL patients. METHODS: Three hundred and forty-seven consecutive PPGL patients from January 2002 through December 2014 were randomly divided into a training set (n=208) and a validation set (n=139). A multivariate logistic regression analysis of selected prognostic features was performed, and a nomogram to predict metastasis was constructed...
April 21, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28428062/a-nomogram-to-predict-prognosis-after-surgery-in-early-stage-non-small-cell-lung-cancer-in-elderly-patients
#10
Fenghao Sun, Ke Ma, Xiaodong Yang, Ming Li, Yu Shi, Cheng Zhan, Wei Jiang, Qun Wang
BACKGROUND: The aim of this study was to identify risk factors affecting overall survival (OS) of elderly patients with early stage NSCLC, and develop a nomogram for prognostic prediction of these patients using data from the Surveillance, Epidemiology, and End Results (SEER) database. METHODS: Data from the SEER database of patients aged ≥ 65 years with early (T1N0M0) NSCLC diagnosed between 2004 and 2013 were examined. The prognostic effect of each variable on survival was evaluated using the Kaplan-Meier method and the Cox proportional hazards regression model...
April 17, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28427516/prognostic-and-predictive-biomarkers-in-neuroendocrine-tumours
#11
REVIEW
David L Chan, Stephen J Clarke, Connie I Diakos, Paul J Roach, Dale L Bailey, Simron Singh, Nick Pavlakis
Neuroendocrine tumours are extremely heterogeneous malignancies. Despite marked heterogeneity in clinical course and prognosis, few biomarkers exist to help predict prognosis and guide treatment. Many tumour-based biomarkers (Ki-67, mitotic count, genetic/epigenetic changes and microRNAs) exist, but only Ki-67 and mitotic count have strong evidence to support their routine use. Blood-based markers are easily repeatable, but currently established biomarkers (chromogranin A and urinary 5-HIAA) are difficult to measure accurately in practice...
May 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28427214/high-mucin-5ac-expression-predicts-adverse-postoperative-recurrence-and-survival-of-patients-with-clear-cell-renal-cell-carcinoma
#12
Haijian Zhang, Yidong Liu, Huyang Xie, Weisi Liu, Qiang Fu, Dengfu Yao, Jiejie Xu, Jianxin Gu
BACKGROUND: Mucin 5AC (MUC5AC), as a member of secreted/gel-forming mucin family, was frequently found to be abnormally expressed in inflammation or malignant diseases. However, the clinic pathologic features and prognostic values of MUC5AC in clear-cell renal cell carcinoma (ccRCC) have not been reported up to now. METHODS: MUC5AC expression was analyzed by immunohistochemistry on tissue microarrays. Kaplan-Meier survival curves, Univariate and Multivariate Cox analysis and newly-established nomogram model were performed to evaluate the prognostic value...
March 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28426465/neoadjuvant-treatment-a-novel-standard
#13
Sandro Pasquali, Elena Palassini, Silvia Stacchiotti, Paolo G Casali, Alessandro Gronchi
PURPOSE OF REVIEW: The aim of this study was to summarize developments in the adjuvant/neoadjuvant chemotherapy of high-risk adult-type soft tissue sarcomas (STS). RECENT FINDINGS: The role of adjuvant/neaodjuvant chemotherapy in these patients is controversial, with a meta-analysis suggesting a 10% survival benefit. Recently, a randomized controlled trial in high-risk STS of extremities and trunk wall showed a 20% improvement in progression-free and overall survival after three preoperative cycles of epirubicin along with ifosfamide compared with a histology-tailored chemotherapy...
April 19, 2017: Current Opinion in Oncology
https://www.readbyqxmd.com/read/28424937/model-to-predict-cause-specific-mortality-in-patients-with-head-and-neck-adenoid-cystic-carcinoma-a-competing-risk-analysis
#14
Weidong Shen, Naoko Sakamoto, Limin Yang
PURPOSE: The main objective of this study was to evaluate the cumulative incidence of cause-specific death and other causes of death for patients with head and neck adenoid cystic carcinoma (ACC). The secondary aim was to model the probability of cause-specific death and build a competing risk nomogram to predict cause-specific mortality for this disease. METHODS: Data were extracted from the US National Cancer Institute's Surveillance Epidemiology, and End Results (SEER)-18 dataset...
April 19, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28423668/ahnak2-is-a-potential-prognostic-biomarker-in-patients-with-pdac
#15
Di Lu, Junxiong Wang, Xiaoyan Shi, Bing Yue, Jianyu Hao
BACKGROUND: AHNAK nucleoprotein 2 (AHNAK2) belongs to the AHNAK protein family. The studies of AHNAK2 are limited. A recent study reported that AHNAK2 might be a biomarker for pancreatic ductal adenocarcinoma (PDAC); however, tissue-based experiments have not been conducted. The aim of this study was to determine the tissue expression of AHNAK2 and to find the correlation between AHNAK2 and overall survival rate in PDAC. RESULTS: AHNAK2 is highly expressed in PDAC (n=79) compared with adjacent normal tissues (n=64, P<0...
March 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28418838/predicting-level-2-axillary-lymph-node-metastasis-in-a-chinese-breast-cancer-population-post-neoadjuvant-chemotherapy-development-and-assessment-of-a-new-predictive-nomogram
#16
Caigang Liu, Yanlin Jiang, Xin Gu, Zhen Xu, Liping Ai, Hao Zhang, Guanglei Chen, Lisha Sun, Yue Li, Hong Xu, Huizi Gu, Ying Yu, Yangyang Xu, Qiyong Guo
BACKGROUND: We aimed to develop a new nomogram to predict the probability of level 2 axillary lymph node metastasis (L-2-ALNM) in breast cancer (BC) patients treated with neoadjuvant chemotherapy (NAC). METHODS: Data were collected from 709 patients who received neoadjuvant chemotherapy and then underwent axillary lymph node (ALN) dissection between May 2009 and December 2015 at the Liaoning Cancer Hospital. The level 2 axillary lymph node metastasis (L-2-ALNM ) nomogram was created from the logistic regression model...
March 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28417967/nomograms-for-predicting-the-prognostic-value-of-serological-tumor-biomarkers-in-colorectal-cancer-patients-after-radical-resection
#17
Qingguo Li, Weixing Dai, Yaqi Li, Ye Xu, Xinxiang Li, Sanjun Cai
A wide range of serum tumor biomarkers, including CA19-9, CA242, CA72-4, CA50, and CA125, has been studied in association with colorectal cancer (CRC). However, few previous studies have comprehensively considered the above tumor biomarkers to assess their clinical significance in predicting prognosis. Data from Fudan University Shanghai Cancer Center (FUSCC) between January 1, 2007 and December 30, 2012 was retrospectively analyzed. Univariate and multivariate analyses were performed to assess the association between prognostic factors and survival outcomes...
April 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28417592/individualising-the-dose-of-allopurinol-in-patients-with-gout
#18
Diluk R W Kannangara, Garry G Graham, Daniel F B Wright, Sophie L Stocker, Ian Portek, Kevin D Pile, Murray L Barclay, Kenneth M Williams, Lisa K Stamp, Richard O Day
AIMS: The aims of the study were to 1) determine if a plasma oxypurinol concentration-response relationship or an allopurinol dose-response relationship best predicts the dose requirements of allopurinol in the treatment of gout; and, 2) to construct a nomogram for calculating the optimum maintenance dose of allopurinol to achieve target serum urate (SU) concentrations. METHODS: A non-linear regression analysis was used to examine the plasma oxypurinol concentration- and allopurinol dose-response relationships with serum urate...
April 18, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28417341/external-validation-of-a-nomogram-including-the-computed-tomography-imaging-score-to-predict-indolent-renal-masses
#19
X Chen, B Wan, D Yang, H Zhao, W Tan
PURPOSE: To assess a nomogram including the computed tomography (CT) score and body mass index (BMI) that was constructed to predict indolent diseases in a cohort of patients with renal masses. MATERIALS AND METHODS: The data collected from patients undergoing partial nephrectomy (PN) or radical nephrectomy (RN) between January 2012 and September 2016 were analyzed. Two urologic surgeons and a radiologist reviewed the images to determine the CT score. Postoperative pathological assessment was performed to categorize renal masses as either indolent or aggressive...
April 17, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28415740/development-and-validation-of-nomograms-for-predicting-survival-in-patients-with-non-metastatic-colorectal-cancer
#20
Huihong Jiang, Erjiang Tang, Dan Xu, Ying Chen, Yong Zhang, Min Tang, Yihua Xiao, Zhiyong Zhang, Xiaxing Deng, Huaguang Li, Moubin Lin
BACKGROUND: This study aimed to develop nomograms for predicting survival in patients with non-metastatic colorectal cancer (CRC). RESULTS: On multivariate analyses of the derivation set, the nomograms for OS and CSS shared common significant prognostic factors: age, first-degree relative cancer history, differentiation grade, vessels/nerves invasion, TNM stage, CEA, CA19-9 and PNI. The nomograms displayed good accuracy in predicting OS and CSS, with C-indexes of 0...
March 13, 2017: Oncotarget
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