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https://www.readbyqxmd.com/read/28096377/comparative-genomics-reveals-convergent-evolution-between-the-bamboo-eating-giant-and-red-pandas
#1
Yibo Hu, Qi Wu, Shuai Ma, Tianxiao Ma, Lei Shan, Xiao Wang, Yonggang Nie, Zemin Ning, Li Yan, Yunfang Xiu, Fuwen Wei
Phenotypic convergence between distantly related taxa often mirrors adaptation to similar selective pressures and may be driven by genetic convergence. The giant panda (Ailuropoda melanoleuca) and red panda (Ailurus fulgens) belong to different families in the order Carnivora, but both have evolved a specialized bamboo diet and adaptive pseudothumb, representing a classic model of convergent evolution. However, the genetic bases of these morphological and physiological convergences remain unknown. Through de novo sequencing the red panda genome and improving the giant panda genome assembly with added data, we identified genomic signatures of convergent evolution...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28095802/a-case-control-study-investigating-factors-associated-with-high-infant-death-in-saiha-district-of-mizoram-india-bordering-myanmar
#2
Alok K Deb, Shanta Dutta, Chhaihlo Hnichho, Mary Vanlalpeki, Hli Thapi Phosa, Khaila Rakhu, Samuel Lalfakawma Fanai, Manoj Chakrabarti, Samiran Panda
BACKGROUND: Infant mortality has dropped considerably in India over the last 5 years. A sharp contrast to this decline in national average of infant mortality is the rate recorded during 2014-2015 from the southernmost district of Saiha, Mizoram having a common international border with Myanmar. As this district specific rate (113 per 1000 live births) is 3 times higher compared to the national and state average, the present investigation was carried out to identify associated factors...
January 17, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28091600/urinary-profiles-of-luteinizing-hormone-estrogen-and-progestagen-during-the-estrous-and-gestational-periods-in-giant-pandas-ailuropda-melanoleuca
#3
Kailai Cai, Shangmian Yie, Zhihe Zhang, Juan Wang, Zhigang Cai, Li Luo, Yuliang Liu, Hairui Wang, He Huang, Chengdong Wang, Xiangming Huang, Jingchao Lan, Rong Hou
Luteinizing hormone (LH) is one of the main pituitary hormones that regulate ovulation, however its role has not been studied in giant panda. In this study, we developed an ELISA method for the detection of panda urinary LH. We analyzed urinary hormones of 24 female pandas during 36 breeding periods, we found females could easily be impregnated if the first mating occurred within 10 hours after LH peak. We also found the patterns of the ratios of urinary LH and progestagen in pandas that bred and successfully gave birth were significantly different from those that bred but failed to give birth...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28080204/identification-of-hur-target-circular-rnas-uncovers-suppression-of-pabpn1-translation-by-circpabpn1
#4
Kotb Abdelmohsen, Amaresh C Panda, Rachel Munk, Ioannis Grammatikakis, Dawood B Dudekula, Supriyo De, Jiyoung Kim, Ji Heon Noh, Kyoung Mi Kim, Jennifer L Martindale, Myriam Gorospe
HuR influences gene expression programs and hence cellular phenotypes by binding to hundreds of coding and noncoding linear RNAs. However, whether HuR binds to circular RNAs (circRNAs) and impacts on their function is unknown. Here, we have identified en masse circRNAs binding HuR in human cervical carcinoma HeLa cells. One of the most prominent HuR target circRNAs was hsa_circ_0031288, renamed CircPABPN1 as it arises from the PABPN1 pre-mRNA. Further analyses revealed that HuR did not influence CircPABPN1 abundance; interestingly, however, high levels of CircPABPN1 suppressed HuR binding to PABPN1 mRNA...
January 12, 2017: RNA Biology
https://www.readbyqxmd.com/read/28075578/probing-structural-perturbation-in-a-bent-molecular-crystal-with-synchrotron-infrared-microspectroscopy-and-periodic-density-functional-theory-calculations
#5
Ljupco Pejov, Manas K Panda, Taro Moriwaki, Pance Naumov
The range of unit cell orientations generated at the kink of a bent single crystal poses unsurmountable challenges with diffraction analysis and limits the insight into the molecular-scale mechanism of bending. On a plastically bent crystal of hexachlorobenzene it is demonstrated here that spatially resolved microfocus infrared spectroscopy using synchrotron radiation can be applied in conjunction with periodic density functional theory calculations to predict spectral changes or to extract information on structural changes that occur as a consequence of bending...
January 11, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28075132/discovery-of-imidazo-1-2-a-pyridine-ethers-and-squaramides-as-selective-and-potent-inhibitors-of-mycobacterial-adenosine-triphosphate-atp-synthesis
#6
Subramanyam J Tantry, Shankar D Markad, Vikas Shinde, Jyothi Bhat, Gayathri Balakrishnan, Amit K Gupta, Anisha Ambady, Anandkumar V Raichurkar, Chaitanyakumar Kedari, Sreevalli Sharma, Naina V Mudugal, Ashwini Narayan, C N Naveen Kumar, Robert Nanduri, Sowmya Bharath, Jitendar Reddy, Vijender Panduga, Prabhakar K R, Karthikeyan Kandaswamy, Ramanatha Saralaya, Parvinder Kaur, Neela Dinesh, Supreeth Guptha, Kirsty Rich, David Murray, Helen Plant, Marian Preston, Helen Ashton, Darren Plant, Jarrod Walsh, Peter Alcock, Kathryn Naylor, Matthew Collier, James Whiteaker, Robert E McLaughlin, Meenakshi Mallya, Manoranjan Panda, Suresh Rudrapatna, Vasanthi Ramachandran, Radha K Shandil, Vasan K Sambandamurthy, Khisimuzi Mdluli, Christopher B Cooper, Harvey Rubin, Takahiro Yano, Pravin S Iyer, Shridhar Narayanan, Stefan Kavanagh, Kakoli Mukherjee, V Balasubramanian, Vinayak P Hosagrahara, Suresh Solapure, Sudha Ravishankar, Shahul Hameed P
The approval of bedaquiline to treat tuberculosis has validated adenosine triphosphate (ATP) synthase as an attractive target to kill Mycobacterium tuberculosis. Herein, we report the discovery of two diverse lead series imidazo[1,2-a]pyridine ethers (IPE) and squaramides (SQA) as inhibitors of mycobacterial ATP-synthesis. Through medicinal chemistry exploration, we established a robust structure activity relationship of these two scaffolds resulting in nanomolar potencies in an ATP-synthesis inhibition assay...
January 11, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28071981/genetic-variation-in-wild-and-hatchery-population-of-catla-catla-hamilton-1822-analyzed-through-mtdna-cytochrome-b-region
#7
Bijay Kumar Behera, Swaraj Priyaranjan Kunal, Vishwamitra Singh Baisvar, Dharmendra Kumar Meena, Debarata Panda, Sudip Pakrashi, Prasenjit Paria, Pronob Das, Dipesh Debnath, Pranaya Kumar Parida, Basanta Kumar Das, Joykrushna Jena
Catla (Catla catla) is a one of the most harvested Indian major carps and is widely cultured fish species in Indian subcontinent. In the present study, genetic variability between hatchery and wild stocks of Catla was surveyed using sequence data of mitochondrial DNA of partial 307 bp of cytochrome b region. A total of 174 Catla individuals were examined from three different river basins and hatcheries. Significant genetic heterogeneity was observed for the sequence data (FST = 0.308, p ≤ 0.001)...
January 10, 2017: Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
https://www.readbyqxmd.com/read/28071641/epidemiological-data-and-case-load-spectrum-of-patients-presenting-to-bone-and-soft-tissue-disease-management-group-at-a-tertiary-cancer-center
#8
A Gulia, A Puri, S Chorge, P K Panda
INTRODUCTION AND BACKGROUND: This study was conducted to know the spectrum and number of bone and soft tissue (BST) tumors presenting to our institute. We needed to assess the gap between the number of patients seen and infrastructure available, and based on this information, help formulate guidelines for optimum utilization of resources and to provide best possible evidence-based cancer care. SETTINGS AND DESIGNS: This is a prospective observational study (epidemiological)...
April 2016: Indian Journal of Cancer
https://www.readbyqxmd.com/read/28070848/intravaginal-delivery-of-polyphenon-60-and-curcumin-nanoemulsion-gel
#9
Atinderpal Kaur, Yashaswee Saxena, Rakhi Bansal, Sonal Gupta, Amit Tyagi, Rakesh Kumar Sharma, Javed Ali, Amulya Kumar Panda, Reema Gabrani, Shweta Dang
Polyphenon 60 (P60) and curcumin (CUR) were loaded in a single nanoemulsion system and their combined antibacterial action was studied against uropathogenic Escherichia coli. To enhance availability at target organs and to inhibit enzymatic degradation in gastro intestinal tract, vaginal route of administration was explored. P60 + CUR nanoemulsion (NE) was formulated by ultra-sonication and optimized using Box-Behnken design. Optimized NE showed Z-average of 211.2 nm, polydispersity index of 0.343, and zeta potential of -32...
January 9, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28069524/atg14-facilitated-lipophagy-in-cancer-cells-induce-er-stress-mediated-mitoptosis-through-a-ros-dependent-pathway
#10
Subhadip Mukhopadhyay, Isabel R Schlaepfer, Bryan C Bergman, Prashanta Kumar Panda, Prakash Priyadarshi Praharaj, Prajna Paramita Naik, Rajesh Agarwal, Sujit Kumar Bhutia
Understanding the dynamics of autophagy and apoptosis crosstalk in cancer progression remains a challenging task. Here, we reported how the autophagy protein ATG14 induces lipophagy-mediated mitochondrial apoptosis. The overexpression of ATG14 in HeLa cells inhibited cell viability and increased mitochondrial apoptosis and endoplasmic reticulum (ER) stress. Furthermore, inhibition of this ATG14-induced autophagy promoted apoptosis. ATG14 overexpression resulted in the accumulation of stearic acid and oleic acid free fatty acids (FFA), with a concomitant decrease in the number of lipid droplets...
January 6, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28069236/recent-advancements-in-the-sonophotocatalysis-spc-and-doped-sonophotocatalysis-dspc-for-the-treatment-of-recalcitrant-hazardous-organic-water-pollutants
#11
REVIEW
Debabrata Panda, Sivakumar Manickam
: Sonophotocatalysis (SPC) is considered to be one of the important wastewater treatment techniques and hence attracted the attention of researchers to eliminate recalcitrant hazardous organic pollutants from aqueous phase. In general, SPC refers to the integrated use of ultrasonic sound waves, ultraviolet radiation and the addition of a semiconductor material which functions as a photocatalyst. Current research has brought numerous improvements in the SPC based treatment by opting visible light irradiation, nanocomposite catalysts and numerous catalyst supports for better stability and performance...
May 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28067055/chemical-composition-and-antioxidant-activity-of-essential-oil-from-leaves-and-rhizomes-of-curcuma-angustifolia-roxb
#12
Sudipta Jena, Asit Ray, Anwesha Banerjee, Ambika Sahoo, Noohi Nasim, Suprava Sahoo, Basudeba Kar, Jeetendranath Patnaik, Pratap Chandra Panda, Sanghamitra Nayak
The essential oil extracted from rhizome and leaf of Curcuma angustifolia Roxb. (Zingiberaceae) was characterised by gas chromatography-mass spectrometry (GC-MS). The GC-MS analysis revealed the presence of 32 and 35 identified constituents, comprising 92.6% and 92% of total leaf and rhizome oil, respectively. Curzerenone (33.2%), 14-hydroxy-δ-cadinene (18.6%) and γ-eudesmol acetate (7.3%) were the main components in leaf oil. In rhizome oil, curzerenone (72.6%), camphor (3.3%) and germacrone (3.3%) were found to be the major constituents...
January 9, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28062908/role-of-altered-cerebello-thalamo-cortical-network-in-the-neurobiology-of-essential-tremor
#13
Abhishek Lenka, Ketaki Swapnil Bhalsing, Rajanikant Panda, Ketan Jhunjhunwala, Rajini M Naduthota, Jitender Saini, Rose Dawn Bharath, Ravi Yadav, Pramod Kumar Pal
INTRODUCTION: Essential tremor (ET) is the most common movement disorder among adults. Although ET has been recognized as a mono-symptomatic benign illness, reports of non-motor symptoms and non-tremor motor symptoms have increased its clinical heterogeneity. The neural correlates of ET are not clearly understood. The aim of this study was to understand the neurobiology of ET using resting state fMRI. METHODS: Resting state functional MR images of 30 patients with ET and 30 age- and gender-matched healthy controls were obtained...
January 6, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28054219/intracranial-aspergillosis-in-an-immunocompetent-young-woman
#14
Prasan Kumar Panda, Sunil Kumar Mavidi, Naveet Wig, Ajay Garg, Aasma Nalwa, M C Sharma
Intracranial aspergillosis (ICA) is very rare in the immunocompetent individuals, usually misdiagnosed as a tumor or an abscess. A high index of clinical suspicion is required in patients who present with focal neurological deficits, headache, or seizures. We report the case of a 25-year-old immunocompetent female, who presented with a 15-month history of headache, seizures, left-sided proptosis and ophthalmoplegia, and right hemiparesis. Recovery from the symptoms and decrease in the lesion size seen on the radiological assessment were achieved through two decompressive craniotomies followed by prolonged combined systemic antifungal therapies...
January 4, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28051146/impacts-of-canine-distemper-virus-infection-on-the-giant-panda-population-from-the-perspective-of-gut-microbiota
#15
Na Zhao, Meng Li, Jing Luo, Supen Wang, Shelan Liu, Shan Wang, Wenting Lyu, Lin Chen, Wen Su, Hua Ding, Hongxuan He
The recent increase in infectious disease outbreaks has been directly linked to the global loss of biodiversity and the decline of some endangered species populations. Between December 2014 and March 2015, five captive giant pandas died due to canine distemper virus (CDV) infection in China. CDV has taken a heavy toll on tigers and lions in recent years. Here, we describe the first gut microbiome diversity study of CDV-infected pandas. By investigating the influence of CDV infection on gut bacterial communities in infected and uninfected individuals and throughout the course of infection, we found that CDV infection distorted the gut microbiota composition by reducing the prevalence of the dominant genera, Escherichia and Clostridium, and increasing microbial diversity...
January 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28050485/metabolic-derangements-in-lichen-planus-a-case-control-study
#16
Bikash Ranjan Kar, Maitreyee Panda, Nibedita Patro
INTRODUCTION: An association between psoriasis and metabolic syndrome has been established in previous studies. Lichen Planus (LP) is also a chronic inflammatory disease morphologically related to psoriasis and few studies have shown association of metabolic derangements in LP. AIM: To study the association of metabolic derangements in LP. MATERIALS AND METHODS: A prospective case control study was undertaken for a period of one year. Age and sex matched patients of LP and other non-inflammatory diseases were taken as cases and controls respectively...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28042769/discovery-of-an-unexplored-protein-structural-scaffold-of-serine-protease-from-big-blue-octopus-octopus-cyanea-a-new-prospective-lead-molecule
#17
Subhamay Panda, Leena Kumari
BACKGROUND: Serine proteases are a group of enzymes that hydrolyses the peptide bonds in proteins. In mammals, these enzymes help in the regulation of several major physiological functions such as digestion, blood clotting, responses of immune system, reproductive functions and the complement system. OBJECTIVE: Serine proteases obtained from the venom of Octopodidae family is a relatively unexplored area of research. In the present work, we tried to effectively utilize comparative composite molecular modeling technique...
January 2, 2017: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/28039891/atmospheric-deposition-exposes-qinling-pandas-to-toxic-pollutants
#18
Yi-Ping Chen, Ying-Juan Zheng, Qiang Liu, Yi Song, Zhi-Sheng An, Qing-Yi Ma, Aaron M Ellison
The giant panda (Ailuropoda melanoleuca) is one of the most endangered animals in the world, and it is recognized worldwide as a symbol for conservation. A previous study showed that wild and captive pandas, especially those of the Qinling subspecies, were exposed to toxicants in their diet of bamboo; the ultimate origin of these toxicants is unknown. Here we show that atmospheric deposition is the most likely origin of heavy metals and persistent organic pollutants (POPs) in the diets of captive and wild Qinling pandas...
December 31, 2016: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/28035119/a-case-of-pseudorheumatism-with-submasseteric-abscess-and-hlh-in-a-patient-with-visceral-leishmaniasis-a-diagnostic-dilemma
#19
Prasan Kumar Panda, Srikant Mohta, S K Sharma, Animesh Ray, Sudheer Arava, Surabhi Vyas
No abstract text is available yet for this article.
October 2016: Journal of Vector Borne Diseases
https://www.readbyqxmd.com/read/28029044/oxidative-aza-annulation-of-enynyl-azides-to-2-keto-formyl-1h-pyrroles
#20
Chada Raji Reddy, Sujatarani A Panda, Andhavaram Ramaraju
A method for the construction of pyrroles bearing 2-keto or formyl group through the intramolecular oxidative aza-annulation of enynyl azides is reported for the first time. It involves a sequential carbon-nitrogen/carbon-oxygen bond formations and the combination of AuCl3 with AgSbF6 was identified as suitable reagent system to promote the present reaction. The required enynyl azides are readily prepared from Morita-Baylis-Hillman (MBH) acetates of acetylenic aldehydes.
December 28, 2016: Journal of Organic Chemistry
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