Lynn Pulliam, Bing Sun, Erin McCafferty, Steven A Soper, Malgorzata A Witek, Mengjia Hu, Judith M Ford, Sarah Song, Dimitrios Kapogiannis, Marshall J Glesby, Daniel Merenstein, Phyllis C Tien, Heather Freasier, Audrey French, Heather McKay, Monica M Diaz, Igho Ofotokun, Jordan E Lake, Joseph B Margolick, Eun-Young Kim, Steven R Levine, Margaret A Fischl, Wei Li, Jeremy Martinson, Norina Tang
Long COVID (LongC) is associated with a myriad of symptoms including cognitive impairment. We reported at the beginning of the COVID-19 pandemic that neuronal-enriched or L1CAM+ extracellular vesicles (nEVs) from people with LongC contained proteins associated with Alzheimer's disease (AD). Since that time, a subset of people with prior COVID infection continue to report neurological problems more than three months after infection. Blood markers to better characterize LongC are elusive. To further identify neuronal proteins associated with LongC, we maximized the number of nEVs isolated from plasma by developing a hybrid EV Microfluidic Affinity Purification (EV-MAP) technique...
March 29, 2024: International Journal of Molecular Sciences