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https://www.readbyqxmd.com/read/28431428/computational-and-in-vitro-experimental-investigation-of-intrathecal-drug-distribution-parametric-study-of-the-effect-of-injection-volume-cerebrospinal-fluid-pulsatility-and-drug-uptake
#1
Kevin M Tangen, Roxanne Leval, Ankit I Mehta, Andreas A Linninger
BACKGROUND: Intrathecal drug delivery is an attractive option to circumvent the blood-brain barrier for pain management through its increased efficacy of pain relief, reduction in adverse side effects, and cost-effectiveness. Unfortunately, there are limited guidelines for physicians to choose infusion or drug pump settings to administer therapeutic doses to specific regions of the spine or the brain. Although empiric trialing of intrathecal drugs is critical to determine the sustained side effects, currently there is no inexpensive in vitro method to guide the selection of spinal drug delivery parameters...
May 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28427846/vaccines-are-different-a-systematic-review-of-budget-impact-analyses-of-vaccines
#2
REVIEW
Priscilla Magalhaes Loze, Luciana Bertholim Nasciben, Ana Marli Christovam Sartori, Alexander Itria, Hillegonda Maria Dutilh Novaes, Patrícia Coelho de Soárez
INTRODUCTION: Several countries require manufacturers to present a budget impact analysis (BIA), together with a cost-effectiveness analysis, to support national funding requests. However, guidelines for conducting BIA of vaccines are scarce. OBJECTIVES: To analyze the methodological approaches used in published budget impact analysis (BIA) of vaccines, discussing specific methodological issues related to vaccines. MATERIAL AND METHODS: This systematic review of the literature on BIA of vaccines was carried out in accordance with the Centre for Reviews and Dissemination - CRD guidelines...
April 17, 2017: Vaccine
https://www.readbyqxmd.com/read/28427762/multidisciplinary-management-of-head-and-neck-cancer-first-expert-consensus-using-delphi-methodology-from-the-spanish-society-for-head-and-neck-cancer-part-2
#3
REVIEW
A Rueda, J Giralt, M Mañós, A Lozano, A Sistiaga, E García-Miragall, J Cacicedo, F Esteban, B Scola, J Contreras, A Ruiz, A Carral, G González-Aniceto, M Pastor, J J Herranz, M Bernal, R Mesía
Head and neck cancer is one of the most frequent malignances worldwide. Despite the site-specific multimodality therapy, up to half of the patients will develop recurrence. Treatment selection based on a multidisciplinary tumor board represents the cornerstone of head and neck cancer, as it is essential for achieving the best results, not only in terms of outcome, but also in terms of organ-function preservation and quality of life. Evidence-based international and national clinical practice guidelines for head and neck cancer not always provide answers in terms of decision-making that specialists have to deal with in their daily practice...
April 17, 2017: Oral Oncology
https://www.readbyqxmd.com/read/28427761/multidisciplinary-management-of-head-and-neck-cancer-first-expert-consensus-using-delphi-methodology-from-the-spanish-society-for-head-and-neck-cancer-part-1
#4
REVIEW
M Mañós, J Giralt, A Rueda, J Cabrera, J Martinez-Trufero, J Marruecos, A Lopez-Pousa, J P Rodrigo, B Castelo, J Martínez-Galán, F Arias, M Chaves, J J Herranz, V Arrazubi, N Baste, A Castro, R Mesía
Head and neck cancer is one of the most frequent malignances worldwide. Despite the site-specific multimodality therapy, up to half of the patients will develop recurrence. Treatment selection based on a multidisciplinary tumor board represents the cornerstone of head and neck cancer, as it is essential for achieving the best results, not only in terms of outcome, but also in terms of organ-function preservation and quality of life. Evidence-based international and national clinical practice guidelines for head and neck cancer not always provide answers in terms of decision-making that specialists must deal with in their daily practice...
April 17, 2017: Oral Oncology
https://www.readbyqxmd.com/read/28422798/anterior-versus-posterior-thoracic-discectomy-a-systematic-review
#5
Eoghan T Hurley, Andrew B Maye, Marcus Timlin, Frank G Lyons
STUDY DESIGN: Systematic literature review OBJECTIVE.: To systematically review the current evidence in the literature on thoracic discectomies, to compare the clinical outcomes and to determine whether there is evidence to support the use of either the anterior or posterior approach. SUMMARY OF BACKGROUND DATA: Thoracic disc herniations often present with myelopathy, radiculopathy or a combination of both. The posterior approach for thoracic discectomy has been associated with a lower complication rate, but no systematic exists comparing the clinical outcomes...
April 18, 2017: Spine
https://www.readbyqxmd.com/read/28420250/the-european-association-of-preventive-cardiology-exercise-prescription-in-everyday-practice-and-rehabilitative-training-expert-tool-a-digital-training-and-decision-support-system-for-optimized-exercise-prescription-in-cardiovascular-disease-concept-definitions
#6
Dominique Hansen, Paul Dendale, Karin Coninx, Luc Vanhees, Massimo F Piepoli, Josef Niebauer, Veronique Cornelissen, Roberto Pedretti, Eva Geurts, Gustavo R Ruiz, Ugo Corrà, Jean-Paul Schmid, Eugenio Greco, Constantinos H Davos, Frank Edelmann, Ana Abreu, Bernhard Rauch, Marco Ambrosetti, Simona S Braga, Olga Barna, Paul Beckers, Maurizio Bussotti, Robert Fagard, Pompilio Faggiano, Esteban Garcia-Porrero, Evangelia Kouidi, Michel Lamotte, Daniel Neunhäuserer, Rona Reibis, Martijn A Spruit, Christoph Stettler, Tim Takken, Cajsa Tonoli, Carlo Vigorito, Heinz Völler, Patrick Doherty
Background Exercise rehabilitation is highly recommended by current guidelines on prevention of cardiovascular disease, but its implementation is still poor. Many clinicians experience difficulties in prescribing exercise in the presence of different concomitant cardiovascular diseases and risk factors within the same patient. It was aimed to develop a digital training and decision support system for exercise prescription in cardiovascular disease patients in clinical practice: the European Association of Preventive Cardiology Exercise Prescription in Everyday Practice and Rehabilitative Training (EXPERT) tool...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28419753/systematic-review-of-gender-differences-in-sepsis-management-and-outcomes
#7
Kim Reina Failla, Cynthia D Connelly
PURPOSE: Contributors to disparities in sepsis management have been attributed to genetic susceptibility, differences in clinical presentation, and healthcare delivery. The influence of gender on survival or mortality of patients with sepsis-related diagnoses is unclear. The purpose of the current study was to systematically review published research to identify factors and outcomes associated with sepsis management and outcomes based on gender differences. METHODS: Covering a period from 2006 to 2016, a literature search was conducted on four electronic data bases including the Cumulative Index to Nursing and Allied Health Literature (CINAHL), EBSCO, MedlinePlus, and PubMed...
April 18, 2017: Journal of Nursing Scholarship
https://www.readbyqxmd.com/read/28418710/lung-cancer-guidelines-in-sweden-denmark-norway-and-finland-a-comparison
#8
Niels Lyhne Christensen, Antti Jekunen, Sebastian Heinonen, Susanne Oksbjerg Dalton, Torben Riis Rasmussen
BACKGROUND: The Nordic countries are similar in terms of demographics and health care organization. Yet there are marked differences in lung cancer mortality, for which Denmark historically has had the poorest outcome. One of several possible reasons for these differences could have to do with how lung cancer is diagnosed and treated in the different Nordic countries. However, among the four most populous Nordic countries: Sweden, Denmark, Norway and Finland, there is a paucity of knowledge about differences and similarities in recommendations in the national guidelines for non-small cell lung cancer (NSCLC) and the methodology by which the guidelines are developed...
April 18, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28416092/cytokines-and-c-reactive-protein-alterations-with-respect-to-cognitive-impairment-in-schizophrenia-and-bipolar-disorder-a-systematic-review
#9
REVIEW
Błażej Misiak, Bartłomiej Stańczykiewicz, Kamila Kotowicz, Janusz K Rybakowski, Jerzy Samochowiec, Dorota Frydecka
BACKGROUND: The aim of this article was to perform a systematic review of studies investigating the association between peripheral levels of cytokines and C-reactive protein (CRP), cytokine gene polymorphisms and cognition in patients with schizophrenia and bipolar disorder (BD). METHODS: The following databases: PubMed, CINAHL Complete, Academic Search Complete, ERIC and Health Source: Nursing/Academic Edition databases were searched according to the PRISMA guidelines...
April 13, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28413843/methodology-used-to-assess-acceptability-of-oral-pediatric-medicines-a-systematic-literature-search-and-narrative-review
#10
REVIEW
Punam Mistry, Hannah Batchelor
BACKGROUND: Regulatory guidelines require that any new medicine designed for a pediatric population must be demonstrated as being acceptable to that population. There is currently no guidance on how to conduct or report on acceptability testing. AIM: Our objective was to undertake a review of the methods used to assess the acceptability of medicines within a pediatric population and use this review to propose the most appropriate methodology. METHODS: We used a defined search strategy to identify literature reports of acceptability assessments of medicines conducted within pediatric populations and extracted information about the tools used in these studies for comparison across studies...
April 17, 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/28413129/return-to-play-after-osteochondral-autograft-transplantation-of-the-capitellum-a-systematic-review
#11
REVIEW
Jacob M Kirsch, Jared R Thomas, Moin Khan, Whitney A Townsend, Jeffrey N Lawton, Asheesh Bedi
PURPOSE: To determine the rate of return to play and to identify lesion or osteochondral graft characteristics that may influence the return to competitive athletics after osteochondral autograft transplantation (OAT) for symptomatic osteochondritis dissecans (OCD) lesions. METHODS: A systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A duplicate search of PubMed, Embase, Scopus, Web of Science, and CENTRAL databases was performed, beginning from the database inception dates through July 2016, for all articles evaluating the return to play after OAT for OCD lesions of the capitellum...
April 13, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28412464/grade-equity-guidelines-1-health-equity-in-guideline-development-introduction-and-rationale
#12
Vivian A Welch, Elie A Akl, Gord Guyatt, Kevin Pottie, Javier Eslava-Schmalbach, Mohammed T Ansari, Hans de Beer, Matthias Briel, Tony Dans, Inday Dans, Monica Hultcrantz, Janet Jull, Srinivasa Vittal Katikireddi, Joerg Meerpohl, Rachael Morton, Annhild Mosdol, Jennifer Petkovic, Holger Schünemann, Ravi Sharaf, Jasvinder Singh, Roger Stanev, Thomy Tonia, Mario Tristan, Sigurd Vitols, Joseph Watine, Peter Tugwell
OBJECTIVES: This paper introduces the rationale and methods for explicitly considering health equity in the GRADE methodology for development of clinical, public health and health system guidelines. STUDY DESIGN AND SETTING: guidance for guideline development STUDY DESIGN AND SETTING: We searched for guideline methodology papers, conceptual papers about health equity and examples of guidelines which considered health equity explicitly. We held three meetings with GRADE working group members, and invited comments from the GRADE working group listserve RESULTS: We developed three papers on incorporating equity considerations into the overall approach to guideline development, rating certainty and assembling the evidence base and evidence to decision/recommendation...
April 12, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28412463/frameworks-for-adaptation-of-health-guidelines-a-methodological-survey
#13
REVIEW
Andrea Darzi, Elias A Abou-Jaoude, Arnav Agarwal, Chantal Lakis, Wojtek Wiercioch, Nancy Santesso, Hneine Brax, Fadi El-Jardali, Holger J Schünemann, Elie A Akl
BACKGROUND: Our objective was to identify and describe published frameworks for adaptation of clinical, public health and health services guidelines. METHODS: We included reports describing methods of adaptation of guidelines in sufficient detail to allow its reproducibility. We searched Medline, and EMBASE databases. We also searched personal files, as well manuals and handbooks of organizations and professional societies that proposed methods of adaptation and adoption of guidelines...
April 12, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28409220/pet-and-pet-ct-with-radiolabeled-choline-in-prostate-cancer-a-critical-reappraisal-of-20-years-of-clinical-studies
#14
REVIEW
Giampiero Giovacchini, Elisabetta Giovannini, Rossella Leoncini, Mattia Riondato, Andrea Ciarmiello
We here aim to provide a comprehensive and critical review of the literature concerning the clinical applications of positron emission tomography/computed tomography (PET/CT) with radiolabeled choline in patients with prostate cancer (PCa). We will initially briefly summarize the historical context that brought to the synthesis of [(11)C]choline, which occurred exactly 20 years ago. We have arbitrarily grouped the clinical studies in three different periods, according to the year in which they were published and according to their relation with their applications in urology, radiotherapy and oncology...
April 14, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28409200/return-to-sport-after-shoulder-arthroplasty-a-systematic-review-and-meta-analysis
#15
Joseph N Liu, Michael E Steinhaus, Grant H Garcia, Brenda Chang, Kara Fields, David M Dines, Russell F Warren, Lawrence V Gulotta
PURPOSE: With increasing incidence and indications for shoulder arthroplasty, there is an increasing emphasis on the ability to return to sports. The main goal of this study was to determine the rate of return to sport after shoulder arthroplasty. METHODS: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed to perform this systematic review and meta-analysis. A search was performed on MEDLINE, Scopus, EMBASE, and the Cochrane Library...
April 13, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28407919/analytical-validation-of-an-ultraviolet-visible-procedure-for-determining-lutein-concentration-and-application-to-lutein-loaded-nanoparticles
#16
Jéssica Thaís do Prado Silva, Anderson Clayton da Silva, Julia Maria Tonin Geiss, Pedro Henrique Hermes de Araújo, Daniela Becker, Lívia Bracht, Fernanda Vitória Leimann, Evandro Bona, Gustavo Petri Guerra, Odinei Hess Gonçalves
Lutein is a carotenoid presenting known anti-inflammatory and antioxidant properties. Lutein-rich diets have been associated with neurological improvement as well as reduction of the risk of vision loss due to Age-Related Macular Degeneration (AMD). Micro and nanoencapsulation have demonstrated to be effective techniques in protecting lutein against degradation and also in improving its bioavailability. However, actual lutein concentration inside the capsules and encapsulation efficiency are key parameters that must be precisely known when designing in vitro and in vivo tests...
September 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28407674/-strategies-for-the-treatment-of-community-acquired-pneumonia-in-hiv-positive-patients
#17
B T Schleenvoigt, J Rupp, G Rohde, J K Rockstroh, G Fätkenheuer, M W Pletz
Study purpose According to the Robert Koch Institute, 84,700 people in Germany suffer from HIV infection. One-third of the affected persons is over 50 years old. In Germany, community-acquired pneumonia (CAP) is a widespread disease with more than 250,000 cases per year. Incidence and mortality increase with the age of the affected individuals. For this reason, diagnostic and therapeutic strategies are needed to guide medical care of HIV-infected patients presenting with CAP. Methodology HIV therapists were interviewed about their diagnostic approach, risk stratification strategy and therapeutic approach to HIV-associated community-acquired pneumonia (HIV( +)/CAP) using a questionnaire...
April 2017: Pneumologie
https://www.readbyqxmd.com/read/28407472/introduction-to-the-centers-for-disease-control-and-prevention-and-healthcare-infection-control-practices-advisory-committee-guideline-for-prevention-of-surgical-site-infection-prosthetic-joint-arthroplasty-section
#18
John Segreti, Javad Parvizi, Elie Berbari, Philip Ricks, Sandra I Berríos-Torres
Peri-prosthetic joint infection (PJI) is a severe complication of total joint arthroplasty that appears to be increasing as more of these procedures are performed. Numerous risk factors for incisional (superficial and deep) and organ/space (e.g., PJI) surgical site infections (SSIs) have been identified. A better understanding and reversal of modifiable risk factors may lead to a reduction in the incidence of incisional SSI and PJI. The Centers for Disease Control and Prevention (CDC) and the Healthcare Infection Control Practices Advisory Committee (HICPAC) recently updated the national Guideline for Prevention of Surgical Site Infection...
April 13, 2017: Surgical Infections
https://www.readbyqxmd.com/read/28407140/development-and-testing-of-candidate-items-for-inclusion-in-a-new-rheumatoid-arthritis-stiffness-patient-reported-outcome-measure
#19
Serena Halls, Emma Dures, John R Kirwan, Jon Pollock, Gill Baker, Avis Edmunds, Sarah Hewlett
Objective.: To qualitatively develop and test a set of candidate items for a new RA stiffness patient-reported outcome measure (PROM) that capture the patient perspective. This is an essential first step in PROM development, prior to quantitative development, assessment and validation. Methods.: Focus groups further examined the previously developed stiffness conceptual model and explored the patient perspective regarding stiffness assessment. Data were analysed using thematic analysis...
April 11, 2017: Rheumatology
https://www.readbyqxmd.com/read/28406669/methodology-of-performance-scoring-in-the-d2-sustained-attention-test-cumulative-reliability-functions-and-practical-guidelines
#20
Michael B Steinborn, Robert Langner, Hagen C Flehmig, Lynn Huestegge
We provide a psychometric analysis of commonly used performance indices of the d2 sustained-attention test, and give methodical guidelines and recommendations, based on this research. We examined experimental effects of repeated testing on performance speed and accuracy (omission and commission errors), and further evaluated aspects of test reliability by means of cumulative reliability function (CRF) analysis. These aspects were also examined for a number of alternative (yet commonly used) scoring techniques and valuation methods...
April 13, 2017: Psychological Assessment
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