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hepatitis B antiviral therapy

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https://www.readbyqxmd.com/read/28918011/nucleic-acid-polymers-with-accelerated-plasma-and-tissue-clearance-for-chronic-hepatitis-b-therapy
#1
Ingo Roehl, Stephan Seiffert, Celia Brikh, Jonathan Quinet, Catherine Jamard, Nadine Dorfler, Jennifer A Lockridge, Lucyna Cova, Andrew Vaillant
REP 2139 is a nucleic acid polymer (NAP) currently under clinical development for chronic hepatitis B (HBV) therapy. This preclinical study investigated different REP 2139 analogs that would display reduced accumulation in the serum and tissues, while retaining an antiviral effect against HBV infection. REP 2139 analogs were evaluated in human plasma, CD-1 mice, cynomolgus monkeys, and Pekin ducks. Discrete ribose transformation to 2'OH in selected riboadenosines resulted in a slow degradation in acidified human plasma that plateaued after 48 hr...
September 15, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/28914852/-efficiency-of-immunosuppressive-therapy-in-virus-negative-and-virus-positive-patients-with-morphologically-verified-lymphocytic-myocarditis
#2
O V Blagova, A V Nedostup, E A Kogan, V A Sulimov
AIM: To evaluate the efficiency of immunosuppressive therapy (IST) in virus-negative (V-) and virus-positive (V+) patients with lymphocytic myocarditis (LM). SUBJECTS AND METHODS: 60 patients (45 males) (mean age 46.7±11.8 years) with dilated cardiomyopathy (mean left ventricular (LV) end diastolic size (EDS) 6.7±0.7 cm; ejection fraction (EF) 26.2±9.1%) were examined. The diagnosis of active/borderline LM was verified by right ventricular endomyocardial biopsy in 38 patients, by intraoperative LV biopsy in 10, in the study of explanted hearts from 3 patients and at autopsy in 9...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28895871/type-i-interferons-in-the-pathogenesis-and-treatment-of-canine-diseases
#3
REVIEW
Daniela Klotz, Wolfgang Baumgärtner, Ingo Gerhauser
Type I interferons (IFNs) such as IFN-α, IFN-β, IFN-ε, IFN-κ, and IFN-ω represent cytokines, which are deeply involved in the regulation and activation of innate and adaptive immune responses. They possess strong antiviral, antiproliferative, and immunomodulatory activities allowing their use in the therapy of different viral diseases, neoplasms, and immune-mediated disorders, respectively. Initially, treatment strategies were based on nonspecific inducers of type I IFNs, which were soon replaced by different recombinant proteins...
September 2017: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/28895581/corrigendum-improvement-of-liver-fibrosis-after-long-term-antiviral-therapy-assessed-by-fibroscan-in-chronic-hepatitis-b-patients-with-advanced-fibrosis
#4
Young Eun Chon, Jun Yong Park, Sung-Min Myoung, Kyu Sik Jung, Beom Kyung Kim, Seung Up Kim, Do Young Kim, Sang Hoon Ahn, Kwang-Hyub Han
No abstract text is available yet for this article.
September 12, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28895260/changes-of-serum-chitinase-3-like-1-levels-correlate-with-changes-of-liver-fibrosis-measured-by-the-two-established-quantitative-methods-in-chronic-hepatitis-b-patients-following-antiviral-therapy
#5
Lin Wang, Tianhui Liu, Jialing Zhou, Hong You, Jidong Jia
AIM: Non-invasive assessment for liver fibrosis change is still an unmet medical need in the era of antiviral therapy. Therefore, we explore whether the chitinase 3-like 1 (CHI3L1), a serum marker of liver fibrosis, can be used as a non-invasive surrogate marker to fibrosis change during treatment. METHODS: We correlated the serum CHI3L1 levels with liver tissue collagen proportionate area (CPA) in a cohort of 131 CHB patients receiving entecavir-based antiviral therapy for 78 weeks...
September 12, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28893758/antiretroviral-therapy-for-pregnant-women-living-with-hiv-or-hepatitis-b-a-systematic-review-and-meta-analysis
#6
Reed A Siemieniuk, Farid Foroutan, Reza Mirza, Jinell Mah Ming, Paul E Alexander, Arnav Agarwal, Olufunmilayo Lesi, Arnaud Merglen, Yaping Chang, Yuan Zhang, Hassan Mir, Elliot Hepworth, Yung Lee, Dena Zeraatkar, Gordon H Guyatt
OBJECTIVE: To assess the impact of various antiretroviral/antiviral regimens in pregnant women living with HIV or hepatitis B virus (HBV). DESIGN: We performed random effects meta-analysis for HIV-related outcomes and network meta-analysis for HBV outcomes, and used the Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework to assess quality separately for each outcome. DATA SOURCES: Embase and Medline to February 2017...
September 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28885711/hepatitis-b-amongst-immigrants-from-myanmar-genotypes-and-their-clinical-relevance
#7
Thomas R Schulz, Rosalind Edwards, M Christine Thurnheer, Lilly Yuen, Margaret Littlejohn, Peter Revill, Melissa Chu, Firuz Tanyeri, Amanda Wade, Beverley-Ann Biggs, Joseph Sasadeusz
Hepatitis B virus (HBV) from 76 adult immigrants in Australia from Myanmar was characterised to determine the prevalence of different HBV genotypes and subgenotypes. A mutational analysis was then performed to determine the presence of clinically significant mutations and correlate them to clinical outcomes. Initial genotyping revealed 68 patients with genotype C (89.5%) and eight patients with genotype B (10.5%). Phylogenetic analysis revealed the large majority of the genotype C infections were of subgenotype C1 (67/68)...
September 8, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28883690/direct-acting-antiviral-agents-against-hepatitis-c-virus-and-lipid-metabolism
#8
EDITORIAL
Tatsuo Kanda, Mitsuhiko Moriyama
Hepatitis C virus (HCV) infection induces steatosis and is accompanied by multiple metabolic alterations including hyperuricemia, reversible hypocholesterolemia and insulin resistance. Total cholesterol, low-density lipoprotein-cholesterol and triglyceride levels are increased by peginterferon and ribavirin combination therapy when a sustained virologic response (SVR) is achieved in patients with HCV. Steatosis is significantly more common in patients with HCV genotype 3 but interferon-free regimens are not always effective for treating HCV genotype 3 infections...
August 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28882423/hepatitis-b-virus-related-mortality-in-rheumatoid-arthritis-patients-undergoing-long-term-low-dose-glucocorticoid-treatment-a-population-based-study
#9
Sheng-Shun Yang, Chin-Tun Hung, Shu-Fen Li, Horng-Mo Lee, Yueh-Chin Chung, Hsin-Hua Chen, Shu-Chuan Chang
BACKGROUND/PURPOSE: Glucocorticoids (GC) are commonly used in rheumatoid arthritis (RA) patients which bears a risk of hepatitis B virus (HBV) reactivation. The purpose of this study was to investigate the risk of HBV-related mortality under long-term low-dose GCs in Taiwanese RA patients. METHODS: We retrospectively analyzed 45,423 RA patients using National Health Insurance Research Database from January 1999 to December 2011. Of them, 2204 patients had the diagnosis of HBV and were classified into four groups according to GCs regimens...
September 4, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28881690/perioperative-entecavir-for-patients-with-hbv-related-hepatocellular-carcinoma-and-low-levels-of-viral-dna-analysis-using-propensity-score-matching
#10
Bao-Hong Yuan, Ru-Hong Li, Wei-Ping Yuan, Bang-De Xiang, Ming-Hua Zheng, Tian Yang, Jian-Hong Zhong, Le-Qun Li
The safety and efficacy of perioperative antiviral therapy for patients with hepatitis B virus related hepatocellular carcinoma and low serum levels of hepatitis B virus DNA are unknown. This retrospective study compared serum levels of hepatitis B virus DNA, liver function, morbidity, and length of hospital stay between patients who underwent hepatic resection alone and patients who received entecavir therapy before and after resection (n = 44 in each group). Propensity score matching was used to reduce confounding due to baseline differences between the groups...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28880694/pronounced-decline-of-serum-hbsag-in-chronic-hepatitis-b-patients-with-long-term-effective-nucleos-t-ide-analogs-therapy
#11
Meng-Lan Wang, En-Qiang Chen, Chuan-Min Tao, Tao-You Zhou, Juan Liao, Dong-Mei Zhang, Juan Wang, Hong Tang
AIMS: This study aims to investigate the kinetics of serum HBsAg levels in chronic hepatitis B patients with long-term nucleos(t)ide analogs (NAs) therapy. METHODS: This was a retrospective clinical study. Serum HBsAg in serial samples of 94 patients, who received at least 8 years of NAs therapy, were measured using Elecsys(®) HBsAg II Quant Assay. RESULTS: In this cohort, serum HBsAg levels reduced from 3.80 log10 IU/mL at baseline to 2...
September 7, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28880197/short-course-of-postoperative-hepatitis-b-immunoglobulin-plus-antivirals-prevents-reinfection-of-liver-transplant-recipients
#12
Kavita Radhakrishnan, Aileen Chi, David J Quan, John P Roberts, Norah A Terrault
BACKGROUND: Hepatitis B immune globulin (HBIG) has been an integral component of prophylaxis against hepatitis B virus (HBV) recurrence in liver transplantation (LT) recipients, but HBIG is costly and inconvenient to administer, prompting consideration of alternative regimens. METHODS: In this retrospective cohort, we report on the success of antiviral therapy combined with a short course (in hospital only) HBIG in liver transplant recipients with HBV DNA less than 100 IU/mL pre-LT...
September 2017: Transplantation
https://www.readbyqxmd.com/read/28879707/analysis-of-hepatitis-c-virus-ns5a-region-in-patients-with-cirrhosis-using-an-ultra-deep-pyrosequencing-method
#13
Fahriye Keskin, Sevgi Ciftci, Filiz Akyuz, Neslihan Abaci, Aris Cakiris, Umit Akyuz, Kadir Demir, Fatih Besisik, Duran Ustek, Sabahattin Kaymakoglu
BACKGROUND: HCV (Hepatitis C Virus) is genetically more diverse than HBV and HIV (Human Immunodeficiency Virus) and exists as quasispecies within infected individuals. This is due to the lack of efficient proofreading of the viral RNA-dependent RNA polymerase. Consequently, quasispecies emerge depending on the mutation rate of the viral polymerase, which may display a high level of genetic variability in a population. In infected individuals, HCV replicates and circulates as quasispecies composed of a complex mixture of different but closely related genomes that undergoes continuous change due to competitive selection and cooperation between arising mutants...
September 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28874869/can-transient-elastography-predict-fibrosis-regression-in-patients-with-chronic-hepatitis-b-during-long-term-antiviral-therapy
#14
Rui Huang, Xiaomin Yan, Yong Liu, Zhaoping Zhang, Chao Wu
No abstract text is available yet for this article.
September 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28865176/feasibility-of-dynamic-risk-prediction-for-hepatocellular-carcinoma-development-in-patients-with-chronic-hepatitis-b
#15
Mi Young Jeon, Hye Won Lee, Seung Up Kim, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Kwang-Hyub Han, Sang Hoon Ahn
BACKGROUND & AIMS: Several risk prediction models for hepatocellular carcinoma (HCC) development are available. We explored whether the use of risk prediction models can dynamically predict HCC development at different time points in chronic hepatitis B (CHB) patients. METHODS: Between 2006 and 2014, 1,397 CHB patients were recruited. All patients underwent serial transient elastography at intervals of >6 months. RESULTS: The median age of the study population (931 males and 466 females) was 49...
September 2, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28860352/factors-contributing-to-the-antiviral-effectiveness-of-tenofovir
#16
Rachel Ann Murphy, Monica Ann Valentovic
Over 1 million people in the United States are living with Human Immunodeficiency Virus (HIV) which may progress to Acquired Immunodeficiency Disease. The use of antiviral therapy has successfully controlled the rate of viral growth in patients. Antiviral agents improve the quality of life and reduce the potential for spreading HIV; HIV is currently considered a chronic disease provided patients are compliant with their antiviral medications. Tenofovir is a nucleoside transcriptase inhibitor that prevents viral replication and is approved for treatment of HIV and chronic hepatitis B infection...
August 31, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28859219/significance-of-definitions-of-relapse-after-discontinuation-of-oral-antivirals-in-hbeag-negative-chronic-hepatitis-b
#17
George V Papatheodoridis, Spilios Manolakopoulos, Tung-Hung Su, Spyros Siakavellas, Chun-Jen Liu, Anastasia Kourikou, Hung-Chih Yang, Jia-Horng Kao
Relapses are observed in most HBeAg-negative chronic hepatitis B patients who discontinue nucleos(t)ide analogues (NAs), but the rates of relapse vary widely among studies and whether all patients with relapse need retreatment is unclear. The aim of this study was to assess the impact of different definitions on the rates of post-treatment relapse and therefore on the probability of retreatment in such patients who discontinued effective long-term NAs therapy. In total, 130 non-cirrhotic HBeAg-negative chronic hepatitis B patients before NAs were included...
August 31, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28857900/regression-of-liver-fibrosis-over-a-24-week-period-after-completing-direct-acting-antiviral-therapy-in-patients-with-chronic-hepatitis-c-receiving-care-within-the-national-hepatitis-c-elimination-program-in-georgia-results-of-hepatology-clinic-hepa-experience
#18
Ekaterine Dolmazashvili, Akaki Abutidze, Nikoloz Chkhartishvili, Marine Karchava, Lali Sharvadze, Tengiz Tsertsvadze
OBJECTIVE: We assessed the impact of direct-acting antiviral (DAA) therapy on liver fibrosis regression measured by transient elastography (TE) in patients with chronic hepatitis C virus (HCV) infection. PATIENTS AND METHODS: A prospective cohort study was carried out in HCV monoinfected patients with advanced liver fibrosis or cirrhosis receiving interferon (IFN)-containing or IFN-free DAA therapy. Liver stiffness (LS) score more than 14.5 kPa indicated LS-defined cirrhosis...
August 29, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28845882/rare-clinically-significant-hepatic-events-and-hepatitis-b-reactivation-occur-more-frequently-following-rather-than-during-direct-acting-antiviral-therapy-for-chronic-hepatitis-c-data-from-a-national-us-cohort
#19
Marina Serper, Kimberly A Forde, David E Kaplan
Recently, cases of hepatitis B virus reactivation (HBVr) with direct acting antiviral therapy (DAAs) for HCV have been reported. However, few data exist from large, Western cohorts. The study objectives were to evaluate the incidence of alanine aminotransferase (ALT) flares, clinically significant hepatic events, and HBVr among a national cohort of US veterans with prior exposure to HBV (anti-HBc+) treated with DAAs. We used a national administrative database to identify patients treated with DAAs from January 2014 through November 2016 and obtained clinical and demographic as well as HBV and HCV treatment data...
August 28, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28840583/therapeutic-implications-of-granulocyte-colony-stimulating-factor-in-patients-with-acute-on-chronic-liver-failure-increased-survival-and-containment-of-liver-damage
#20
Biplob Kumar Saha, Mamun Al Mahtab, Sheikh Mohammad Fazle Akbar, Sheikh Mohammad Noor-E-Alam, Ayub Al Mamun, Sharker Mohammad Shahadat Hossain, Mohammad Ashraful Alam, Ahmed Lutful Moben, Faiz Ahmad Khondaker, Forhadul Islam Chowdhury, Ruksana Raihan, Salimur Rahman, Ashok Kumar Choudhury
BACKGROUND AND PURPOSE: Mobilization of bone marrow-derived stem cells by granulocyte colony stimulating factor (G-CSF) supports hepatic regeneration and may augment clinical improvement in patients with acute-on-chronic liver failure (ACLF). The aim of this study is to assess the impact of G-CSF on complications and transplant-free survival in patients with ACLF. METHODS: Thirty-two patients with ACLF defined by Asian Pacific Association for the Study of the Liver (APASL) criteria were openly randomized to control (group A) or intervention (group B) receiving G-CSF (5 μg/kg/day, for 6 consecutive days) in addition to standard medical therapy with antiviral drugs...
August 24, 2017: Hepatology International
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