Ting Chen, Yuki Mori, Chizuko Inui-Yamamoto, Yutaka Komai, Yoshiyuki Tago, Shinichi Yoshida, Yoshitsugu Takabatake, Yoshitaka Isaka, Kohji Ohno, Yoshichika Yoshioka
INTRODUCTION: To investigate the biodistribution and retention properties of the new super paramagnetic iron oxide (new SPIO: mean hydrodynamic diameter, 100 nm) nanoparticles, which have concentrated polymer brushes in the outer shell and are difficult for phagocytes to absorb, and to compare the new SPIO with clinically approved SPIO (Resovist: mean hydrodynamic diameter, 57 nm). MATERIALS AND METHODS: 16 male C57BL/6N mice were divided in two groups according to the administered SPIO (n = 8 for each group; intravenous injection does, 0...
October 10, 2017: Magnetic Resonance in Medical Sciences: MRMS