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https://www.readbyqxmd.com/read/28445151/trefoil-factor-3-mediation-of-oncogenicity-and-chemoresistance-in-hepatocellular-carcinoma-is-akt-bcl-2-dependent
#1
Ming-Liang You, Yi-Jun Chen, Qing-Yun Chong, Ming-Ming Wu, Vijay Pandey, Ru-Mei Chen, Liang Liu, Lan Ma, Zheng-Sheng Wu, Tao Zhu, Peter E Lobie
The efficacious treatment of hepatocellular carcinoma (HCC) remains a challenge, partially being attributed to intrinsic chemoresistance. Previous reports have observed increased TFF3 expression in HCC. Herein, we investigated the functional role of TFF3 in progression of HCC, and in both intrinsic and acquired chemoresistance. TFF3 expression was observed to be upregulated in HCC and associated with poor clinicopathological features and worse patient survival outcome. Functionally, forced expression of TFF3 in HCC cell lines increased cell proliferation, cell survival, anchorage-independent and 3D matrigel growth, cell invasion and migration, and in vivo tumor growth...
April 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28405143/diagnostic-value-evaluation-of-trefoil-factors-family-3-for-the-early-detection-of-colorectal-cancer
#2
Hui Xie, Jian-Hai Guo, Wei-Min An, Sheng-Tao Tian, Hai-Peng Yu, Xue-Ling Yang, Hua-Ming Wang, Zhi Guo
AIM: The purpose of this study was to evaluate the diagnostic value of trefoil factor family 3 (TFF3) for the early detection of colorectal cancer (CC). METHODS: Serum TFF3 and carcino-embryonic antigen (CEA) were detected in 527 individuals, including 115 healthy control (HC), 198 colorectal adenoma (CA), and 214 CC individuals in the training group. RESULTS: Serum TFF3 showed no significant correlation with age, gender, or tumor location but showed significant correlation with the tumor stage...
March 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28393177/difficulty-in-obtaining-the-complete-mrna-coding-sequence-at-5-%C3%A2-region-5-%C3%A2-end-mrna-artifact-causes-consequences-in-biology-and-medicine-and-possible-solutions-for-obtaining-the-actual-amino-acid-sequence-of-proteins-review
#3
Lorenza Vitale, Maria Caracausi, Raffaella Casadei, Maria Chiara Pelleri, Allison Piovesan
The known difficulty in obtaining the actual full length, complete sequence of a messenger RNA (mRNA) may lead to the erroneous determination of its coding sequence at the 5' region (5' end mRNA artifact), and consequently to the wrong assignment of the translation start codon, leading to the inaccurate prediction of the encoded polypeptide at its amino terminus. Among the known human genes whose study was affected by this artifact, we can include disco interacting protein 2 homolog A (DIP2A; KIAA0184), Down syndrome critical region 1 (DSCR1), SON DNA binding protein (SON), trefoil factor 3 (TFF3) and URB1 ribosome biogenesis 1 homolog (URB1; KIAA0539) on chromosome 21, as well as receptor for activated C kinase 1 (RACK1, also known as GNB2L1), glutaminyl‑tRNA synthetase (QARS) and tyrosyl-DNA phosphodiesterase 2 (TDP2) along with another 474 loci, including interleukin 16 (IL16)...
April 6, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28357642/genome-wide-gene-expression-profiling-of-tongue-squamous-cell-carcinoma-by-rna-seq
#4
Hai Xia Zhang, Ou Sheng Liu, Chao Deng, Yan He, Ye Qian Feng, Jin An Ma, Chun Hong Hu, Zhan Gui Tang
OBJECTIVE: Tongue squamous cell carcinoma (TSCC) is significantly more malignant than other type of oral squamous cell carcinoma (OSCC). In this study, we aimed to identify specific global gene expression signatures of TSCC to investigate the more invasive behavior of the deeply infiltrating cancer. METHODS: Using RNA-seq technology, we detected gene expression of 20 TSCCs, 20 matched paratumor tissues, and 10 healthy normal mucosa tissues. Enrichment analysis of gene ontology (GO) and pathway was conducted using online tools DAVID for the dysregulated genes...
March 29, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28357579/epithelial-cell-types-and-their-proposed-roles-in-maintaining-the-mucosal-barrier-in-human-chagasic-megacolonic-mucosa
#5
Christian Koch, Alexandre B M da Silveira, Enio C de Oliveira, Karl Quint, Winfried Neuhuber, Axel Brehmer, Samir Jabari
Patients suffering from chagasic megacolon must have an intact mucosal barrier as they survive this chronic disease for decades. A key structure of the mucosal barrier are epithelial cells. Vasoactive-intestinal-peptide (VIP)-positive nerve fibres are involved in influencing, e.g., epithelial cell proliferation, mucus secretion (e.g., mucin 2 and trefoil factor 3 of goblet cells) and inflammation or autoimmunity, all putative and/or known factors altered in chagasic megacolon. We analyzed qualitatively and quantitatively goblet cells, their specific markers, such as mucin 2 (MUC2) and trefoil factor 3 (TFF3) and enterocytes, the relation of VIP-immunoreactive nerve fibres to the epithelia, the distribution of gelsolin, a protein involved in chronic inflammation processes in the epithelia, and the proliferation rate of epithelial cells by combined 4',6-diamidino-2-phenylindole (DAPI) and phosphohistone-H3 (PHH3) staining...
March 29, 2017: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/28346473/oral-administration-of-bifidobacterium-bifidum-g9-1-alleviates-rotavirus-gastroenteritis-through-regulation-of-intestinal-homeostasis-by-inducing-mucosal-protective-factors
#6
Tomohiro Kawahara, Yutaka Makizaki, Yosuke Oikawa, Yoshiki Tanaka, Ayako Maeda, Masaki Shimakawa, Satoshi Komoto, Kyoko Moriguchi, Hiroshi Ohno, Koki Taniguchi
Human rotavirus (RV) infection is a leading cause of dehydrating diarrhea in infants and young children worldwide. Since therapeutic approaches to RV gastroenteritis are limited to alleviation of dehydration with oral rehydration solutions, more direct approaches to palliate symptoms of RV gastroenteritis are required. Treatments with probiotics have been increasingly recognized as alternative safe and low cost treatments for moderate infectious diarrhea. In this study, Bifidobacterium bifidum G9-1 (BBG9-1), which has been used as an intestinal drug for several decades, was shown to have a remarkable protective effect against RV gastroenteritis in a suckling mice model...
2017: PloS One
https://www.readbyqxmd.com/read/28346392/impact-of-novel-sorghum-bran-diets-on-dss-induced-colitis
#7
Lauren E Ritchie, Stella S Taddeo, Brad R Weeks, Raymond J Carroll, Linda Dykes, Lloyd W Rooney, Nancy D Turner
We have demonstrated that polyphenol-rich sorghum bran diets alter fecal microbiota; however, little is known regarding their effect on colon inflammation. Our aim was to characterize the effect of sorghum bran diets on intestinal homeostasis during dextran sodium sulfate (DSS)-induced colitis. Male Sprague-Dawley rats (N = 20/diet) were provided diets containing 6% fiber from cellulose, or Black (3-deoxyanthocyanins), Sumac (condensed tannins) or Hi Tannin Black (both) sorghum bran. Colitis was induced (N = 10/diet) with three separate 48-h exposures to 3% DSS, and feces were collected...
March 27, 2017: Nutrients
https://www.readbyqxmd.com/read/28149533/tff3-dependent-resistance-of-human-colorectal-adenocarcinoma-cells-ht-29-b6-to-apoptosis-is-mediated-by-mir-491-5p-regulation-of-lncrna-prins
#8
Carlos Hanisch, Jutta Sharbati, Barbara Kutz-Lohroff, Otmar Huber, Ralf Einspanier, Soroush Sharbati
Tumour necrosis factor-α (TNF-α) is a double-edged cytokine associated with pathogenesis of inflammatory-related cancers being also able to induce cancer cell death. In the process of tumour development or metastasis, cancer cells can become resistant to TNF-α. In trefoil factor 3 (TFF3) overexpressing colorectal adenocarcinoma cells (HT-29/B6), we observed enhanced resistance against TNF-α/interferon gamma-induced apoptosis. TFF3 is a secreted small peptide that supports intestinal tissue repair but is also involved in intestinal tumour progression and scattering...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28104986/expression-of-trefoil-factors-and-twist1-in-colorectal-cancer-and-their-correlation-with-metastatic-potential-and-prognosis
#9
Akram Yusup, Bailikezi Huji, Cheng Fang, Fei Wang, Tuerxunjiang Dadihan, Hai-Jiang Wang, Halmurat Upur
AIM: To detect the expression of trefoil factors (TFFs) and TWIST1 in colorectal cancer (CRC) and analyze their correlation with metastasis and survival. METHODS: This study examined the expression of TFF1, TFF3 and TWIST1 in a total of 75 tumor samples, 47 matched normal samples (15 cm from the lesion margin), 30 metastatic lymph nodes, and 10 liver metastatic cancer samples from patients with CRC. The relationship was then analyzed between the protein expression and different clinical records...
January 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28070169/overexpression-of-trefoil-factor-3-tff3-contributes-to-the-malignant-progression-in-cervical-cancer-cells
#10
Zhaohu Yuan, Dandan Chen, Xiaojie Chen, Huikuan Yang, Yaming Wei
BACKGROUND: There remains a great need for effective therapies for cervical cancers, the majority of which are aggressive leaving patients with poor prognosis. METHODS AND RESULTS: Here, we identify a novel candidate therapeutic target, trefoil factor 3 (TFF3) which overexpressed in cervical cancer cells and was associated with reduced postoperative survival. Functional studies demonstrated that TFF3 overexpression promoted the proliferation and invasion of cervical cancer cells, and inhibited the apoptosis by inducing the mRNA changes in SiHa and Hela cell lines...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28011908/genital-injury-signatures-and-microbiome-alterations-associated-with-depot-medroxyprogesterone-acetate-usage-and-intravaginal-drying-practices
#11
Kenzie D Birse, Laura M Romas, Brandon L Guthrie, Peter Nilsson, Rose Bosire, James Kiarie, Carey Farquhar, Kristina Broliden, Adam D Burgener
Background.: Increasing evidence suggests depot medroxyprogesterone acetate (DMPA) and intravaginal practices may be associated with human immunodeficiency virus (HIV-1) infection risk; however, the mechanisms are not fully understood. This study evaluated the effect of DMPA and intravaginal practices on the genital proteome and microbiome to gain mechanistic insights. Methods.: Cervicovaginal secretions from 86 Kenyan women, including self-reported DMPA users (n = 23), nonhormonal contraceptive users (n = 63), and women who practice vaginal drying (n = 46), were analyzed using tandem-mass spectrometry...
February 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28002630/profiling-of-kidney-injury-biomarkers-in-patients-receiving-cisplatin-time-dependent-changes-in-the-absence-of-clinical-nephrotoxicity
#12
B George, X Wen, N Mercke, M Gomez, C O'Bryant, D W Bowles, Y Hu, S L Hogan, M S Joy, L M Aleksunes
The success of cisplatin-containing regimens to treat solid tumors is limited, in part, by nephrotoxicity. In rodents, several urinary proteins have emerged that are sensitive indicators of cisplatin-induced kidney injury. We sought to characterize time-dependent changes in the urinary concentrations of 12 proteins, including kidney injury molecule-1 (KIM-1), calbindin, beta 2-microglobulin (β2M), and trefoil factor 3 (TFF3) after cisplatin therapy. Urine was collected at baseline, 3 days (range, 2-5 days), and 10 days (range, 9-11 days) from 57 patients with solid tumors receiving outpatient cisplatin therapy (≥25 mg/m(2) )...
April 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27942836/comparison-of-three-different-application-routes-of-butyrate-to-improve-colonic-anastomotic-strength-in-rats
#13
J W A M Bosmans, A C H M Jongen, B T C Boonen, S van Rijn, F Scognamiglio, L Stucchi, M J J Gijbels, E Marsich, N D Bouvy
INTRODUCTION: Despite extensive research, anastomotic leakage (AL) remains one of the most dreaded complications after colorectal surgery. Since butyrate enemas are known to enhance anastomotic healing, several administration routes have been explored in this study. METHODS: Three intraluminal approaches involving butyrate were investigated: (1) butyrin-elucidating patch, (2) a single injection of hyaluronan-butyrate (HA-But) prior to construction of the proximal anastomosis and (3) rectal hyaluronan-butyrate (HA-But) enemas designed for distal anastomoses...
March 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/27918163/-the-role-of-trefoil-factor-family-in-gynecological-disease
#14
D Neubert, R Pilka, D Stejskal, G Krejčí
AIM: Trefoil peptides are a family of small proteins that are expressed in a site-specific fashion by certain epithelial tissues. These peptides appear to be important in mucosal healing processes, in neoplastic disease and in human reproduction. DESIGN: Literature review. SETTING: Department of Obstetrics and Gynaecology, University Hospital, Medical Faculty, Palacký University, Olomouc, Czech Republic; Department of Laboratory Biochemistry, Central Moravian Hospital Trust, Member of Agel holding, Prostějov...
2016: Ceská Gynekologie
https://www.readbyqxmd.com/read/27876210/conditioned-medium-from-ls-174t-goblet-cells-treated-with-oxyresveratrol-strengthens-tight-junctions-in-caco-2-cells
#15
Dahyun Hwang, HyunA Jo, Seonwook Hwang, Jeong-Keun Kim, In-Ho Kim, Young-Hee Lim
BACKGROUND: Strengthening of intestinal tight junctions provides an effective barrier from the external environment. Goblet cell-derived trefoil factor 3 (TFF3) increases transepithelial resistance by upregulating the expression of tight junction proteins. Oxyresveratrol (OXY) is a hydroxyl-substituted stilbene found in the roots, leaves, stems, and fruit of many plants and known to have various biological activities. In this study, we investigated the strengthening effect of OXY on intestinal tight junctions through stimulation of TFF production in goblet cells...
January 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27875772/hnf4%C3%AE-is-a-key-gene-that-can-generate-columnar-metaplasia-in-oesophageal-epithelium
#16
Benjamin J Colleypriest, Zoë D Burke, Leonard P Griffiths, Yu Chen, Wei-Yuan Yu, Ramiro Jover, Michael Bock, Leigh Biddlestone, Jonathan M Quinlan, Stephen G Ward, J Mark Farrant, Jonathan M W Slack, David Tosh
Barrett's metaplasia is the only known morphological precursor to oesophageal adenocarcinoma and is characterized by replacement of stratified squamous epithelium by columnar epithelium. The cell of origin is uncertain and the molecular mechanisms responsible for the change in cellular phenotype are poorly understood. We therefore explored the role of two transcription factors, Cdx2 and HNF4α in the conversion using primary organ cultures. Biopsy samples from cases of human Barrett's metaplasia were analysed for the presence of CDX2 and HNF4α...
January 2017: Differentiation; Research in Biological Diversity
https://www.readbyqxmd.com/read/27832633/increased-cerebral-tff1-expression-in-two-murine-models-of-neuroinflammation
#17
Eva B Znalesniak, Ting Fu, Karina Guttek, Ulrike Händel, Dirk Reinhold, Werner Hoffmann
BACKGROUND/AIMS: The trefoil factor family (TFF) peptide TFF1 is a typical secretory product of the gastric mucosa and a very low level of expression occurs in nearly all regions of the murine brain. TFF1 possesses a lectin activity and binding to a plethora of transmembrane glycoproteins could explain the diverse biological effects of TFF1 (e.g., anti-apoptotic effect). It was the aim to test whether TFF expression is changed during neuroinflammation. METHODS: Expression profiling was performed using semi-quantitative RT-PCR analyses in two murine models of neuroinflammation, i...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27829249/dcr3-tff3-and-midkine-are-novel-serum-biomarkers-in-small-intestinal-neuroendocrine-tumors
#18
Katarina Edfeldt, Kosmas Daskalakis, Christofer Bäcklin, Olov Norlén, Eva Tiensuu Janson, Gunnar Westin, Per Hellman, Peter Stålberg
Small intestinal neuroendocrine tumors (SI-NETs) are amine- and peptide producing neoplasms. Most patients display metastases at the time of diagnosis, they have an unpredictable individual disease course and the tumors are often therapy resistant. Chromogranin A (CgA) and 5-hydroxyindoleacetic acid (5-HIAA) are the clinically most used biomarkers today, but there is a great need for novel diagnostic and prognostic biomarkers and new therapeutic targets. Sixty-nine biomarkers were screened in serum from 23 SI-NET patients and 23 healthy controls using multiplex PLA (proximity ligation assay)...
November 9, 2016: Neuroendocrinology
https://www.readbyqxmd.com/read/27758987/prognostic-significance-of-surfactant-protein-a-surfactant-protein-d-clara-cell-protein-16-s100-protein-trefoil-factor-3-and-prostatic-secretory-protein-94-in-idiopathic-pulmonary-fibrosis-sarcoidosis-and-chronic-pulmonary-obstructive-disease
#19
COMPARATIVE STUDY
Martina Doubková, Michal Karpíšek, Jiri Mazoch, Jana Skřičková, Michael Doubek
BACKGROUND: Identification of serum and bronchoalveolar lavage fluid (BALF) biomarkers may facilitate diagnosis and prognostication in various lung disorders. OBJECTIVE: Serum and BALF levels of surfactant protein A (SP-A), surfactant protein D (SP-D), Clara cell protein 16 (CC16), S100 protein, trefoil factor 3 (TFF3), and prostatic secretory protein 94 (PSP94) were evaluated in 94 consecutive patients (idiopathic pulmonary fibrosis (IPF; n=18), sarcoidosis (n=25), chronic obstructive pulmonary disease (COPD; n=51)), and in 155 healthy controls...
October 7, 2016: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
https://www.readbyqxmd.com/read/27731922/inducible-gene-modification-in-the-gastric-epithelium-of-tff1-creert2-tff2-rtta-tff3-luc-mice
#20
Stefan Thiem, Moritz F Eissmann, Emma Stuart, Joachim Elzer, Anna Jonas, Michael Buchert, Matthias Ernst
Temporal and spatial regulation of genes mediated by tissue-specific promoters and conditional gene expression systems provide a powerful tool to study gene function in health, disease, and during development. Although transgenic mice expressing the Cre recombinase in the gastric epithelium have been reported, there is a lack of models that allow inducible and reversible gene modification in the stomach. Here, we exploited the gastrointestinal epithelium-specific expression pattern of the three trefoil factor (Tff) genes and bacterial artificial chromosome transgenesis to generate a novel mouse strain that expresses the CreERT2 recombinase and the reverse tetracycline transactivator (rtTA)...
December 2016: Genesis: the Journal of Genetics and Development
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