keyword
MENU ▼
Read by QxMD icon Read
search

TFF3

keyword
https://www.readbyqxmd.com/read/27918163/-the-role-of-trefoil-factor-family-in-gynecological-disease
#1
D Neubert, R Pilka, D Stejskal, G Krejčí
AIM: Trefoil peptides are a family of small proteins that are expressed in a site-specific fashion by certain epithelial tissues. These peptides appear to be important in mucosal healing processes, in neoplastic disease and in human reproduction. DESIGN: Literature review. SETTING: Department of Obstetrics and Gynaecology, University Hospital, Medical Faculty, Palacký University, Olomouc, Czech Republic; Department of Laboratory Biochemistry, Central Moravian Hospital Trust, Member of Agel holding, Prostějov...
2016: Ceská Gynekologie
https://www.readbyqxmd.com/read/27876210/conditioned-medium-from-ls-174t-goblet-cells-treated-with-oxyresveratrol-strengthens-tight-junctions-in-caco-2-cells
#2
Dahyun Hwang, HyunA Jo, Seonwook Hwang, Jeong-Keun Kim, In-Ho Kim, Young-Hee Lim
BACKGROUND: Strengthening of intestinal tight junctions provides an effective barrier from the external environment. Goblet cell-derived trefoil factor 3 (TFF3) increases transepithelial resistance by upregulating the expression of tight junction proteins. Oxyresveratrol (OXY) is a hydroxyl-substituted stilbene found in the roots, leaves, stems, and fruit of many plants and known to have various biological activities. In this study, we investigated the strengthening effect of OXY on intestinal tight junctions through stimulation of TFF production in goblet cells...
November 18, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27875772/hnf4%C3%AE-is-a-key-gene-that-can-generate-columnar-metaplasia-in-oesophageal-epithelium
#3
Benjamin J Colleypriest, Zoë D Burke, Leonard P Griffiths, Yu Chen, Wei-Yuan Yu, Ramiro Jover, Michael Bock, Leigh Biddlestone, Jonathan M Quinlan, Stephen G Ward, J Mark Farrant, Jonathan M W Slack, David Tosh
Barrett's metaplasia is the only known morphological precursor to oesophageal adenocarcinoma and is characterized by replacement of stratified squamous epithelium by columnar epithelium. The cell of origin is uncertain and the molecular mechanisms responsible for the change in cellular phenotype are poorly understood. We therefore explored the role of two transcription factors, Cdx2 and HNF4α in the conversion using primary organ cultures. Biopsy samples from cases of human Barrett's metaplasia were analysed for the presence of CDX2 and HNF4α...
November 19, 2016: Differentiation; Research in Biological Diversity
https://www.readbyqxmd.com/read/27832633/increased-cerebral-tff1-expression-in-two-murine-models-of-neuroinflammation
#4
Eva B Znalesniak, Ting Fu, Karina Guttek, Ulrike Händel, Dirk Reinhold, Werner Hoffmann
BACKGROUND/AIMS: The trefoil factor family (TFF) peptide TFF1 is a typical secretory product of the gastric mucosa and a very low level of expression occurs in nearly all regions of the murine brain. TFF1 possesses a lectin activity and binding to a plethora of transmembrane glycoproteins could explain the diverse biological effects of TFF1 (e.g., anti-apoptotic effect). It was the aim to test whether TFF expression is changed during neuroinflammation. METHODS: Expression profiling was performed using semi-quantitative RT-PCR analyses in two murine models of neuroinflammation, i...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27829249/dcr3-tff3-and-midkine-are-novel-serum-biomarkers-in-small-intestinal-neuroendocrine-tumors
#5
Katarina Edfeldt, Kosmas Daskalakis, Christofer Bäcklin, Olov Norlén, Eva Tiensuu Janson, Gunnar Westin, Per Hellman, Peter Stålberg
Small intestinal neuroendocrine tumors (SI-NETs) are amine- and peptide producing neoplasms. Most patients display metastases at the time of diagnosis, they have an unpredictable individual disease course and the tumors are often therapy resistant. Chromogranin A (CgA) and 5-hydroxyindoleacetic acid (5-HIAA) are the clinically most used biomarkers today, but there is a great need for novel diagnostic and prognostic biomarkers and new therapeutic targets. Sixty-nine biomarkers were screened in serum from 23 SI-NET patients and 23 healthy controls using multiplex PLA (proximity ligation assay)...
November 9, 2016: Neuroendocrinology
https://www.readbyqxmd.com/read/27758987/prognostic-significance-of-surfactant-protein-a-surfactant-protein-d-clara-cell-protein-16-s100-protein-trefoil-factor-3-and-prostatic-secretory-protein-94-in-idiopathic-pulmonary-fibrosis-sarcoidosis-and-chronic-pulmonary-obstructive-disease
#6
Martina Doubková, Michal Karpíšek, Jiri Mazoch, Jana Skřičková, Michael Doubek
BACKGROUND: Identification of serum and bronchoalveolar lavage fluid (BALF) biomarkers may facilitate diagnosis and prognostication in various lung disorders. OBJECTIVE: Serum and BALF levels of surfactant protein A (SP-A), surfactant protein D (SP-D), Clara cell protein 16 (CC16), S100 protein, trefoil factor 3 (TFF3), and prostatic secretory protein 94 (PSP94) were evaluated in 94 consecutive patients (idiopathic pulmonary fibrosis (IPF; n=18), sarcoidosis (n=25), chronic obstructive pulmonary disease (COPD; n=51)), and in 155 healthy controls...
October 7, 2016: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
https://www.readbyqxmd.com/read/27731922/inducible-gene-modification-in-the-gastric-epithelium-of-tff1-creert2-tff2-rtta-tff3-luc-mice
#7
Stefan Thiem, Moritz F Eissmann, Emma Stuart, Joachim Elzer, Anna Jonas, Michael Buchert, Matthias Ernst
Temporal and spatial regulation of genes mediated by tissue-specific promoters and conditional gene expression systems provide a powerful tool to study gene function in health, disease and during development. Although transgenic mice expressing the Cre recombinase in the gastric epithelium have been reported, there is a lack of models that allow inducible and reversible gene modification in the stomach. Here, we exploited the gastrointestinal epithelium-specific expression pattern of the three trefoil factor (Tff) genes and bacterial artificial chromosome transgenesis to generate a novel mouse strain that expresses the CreERT2 recombinase and the reverse tetracycline transactivator (rtTA)...
October 12, 2016: Genesis: the Journal of Genetics and Development
https://www.readbyqxmd.com/read/27731893/trefoil-factor-peptide-3-is-positively-correlated-with-the-viscoelastic-properties-of-the-cervical-mucus-plug
#8
Sara Kjaer Bastholm, Mie Hesselund Samson, Naja Becher, Lea Kirstine Hansen, Peter Reimer Stubbe, Ioannis S Chronakis, Ebba Nexo, Niels Uldbjerg
INTRODUCTION: The viscoelastic properties of the cervical mucus plug are considered essential for the occlusion of the cervical canal and thereby for protection against ascending infections during pregnancy. Factors controlling this property are virtually unknown. This study explores a possible role of trefoil factor peptides 1, 2 and 3 (TFF1-3); peptides believed to influence mucus viscosity. MATERIALS AND METHODS: The study is based on spontaneously shed cervical mucus plugs from 14 women in active labor...
October 12, 2016: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/27724849/mining-kidney-toxicogenomic-data-by-using-gene-co-expression-modules
#9
Mohamed Diwan M AbdulHameed, Danielle L Ippolito, Jonathan D Stallings, Anders Wallqvist
BACKGROUND: Acute kidney injury (AKI) caused by drug and toxicant ingestion is a serious clinical condition associated with high mortality rates. We currently lack detailed knowledge of the underlying molecular mechanisms and biological networks associated with AKI. In this study, we carried out gene co-expression analyses using DrugMatrix-a large toxicogenomics database with gene expression data from rats exposed to diverse chemicals-and identified gene modules associated with kidney injury to probe the molecular-level details of this disease...
October 10, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27699037/trefoil-factor-3-expression-in-epithelial-ovarian-cancer-exerts-a-minor-effect-on-clinicopathological-parameters
#10
Friederike Hoellen, Athina Kostara, Thomas Karn, Uwe Holtrich, Ahmed El-Balat, Mike Otto, Achim Rody, Lars C Hanker
The role of trefoil factor 3 (intestinal) (TFF3) has been analyzed in numerous cancers, such as breast and gastrointestinal cancer, and has been associated with poor prognosis. However, the role of TFF3 in ovarian cancers is not clear. Expression analysis of TFF3 in 91 ovarian cancer patients was performed by immunohistochemistry of primary paraffin-embedded tumor samples. The results were scored according to staining intensity and percentage of positive tumor cells resulting in an immune-reactive score (IRS) of 0-12...
October 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27626280/forced-trefoil-factor-family-peptide-3-tff3-expression-reduces-growth-viability-and-tumorigenicity-of-human-retinoblastoma-cell-lines
#11
Jan Große-Kreul, Maike Busch, Claudia Winter, Stefanie Pikos, Harald Stephan, Nicole Dünker
Trefoil factor family (TFF) peptides have been shown to effect cell proliferation, apoptosis, migration and invasion of normal cells and various cancer cell lines. In the literature TFF peptides are controversially discussed as tumor suppressors and potential tumor progression factors. In the study presented, we investigated the effect of TFF3 overexpression on growth, viability, migration and tumorigenicity of the human retinoblastoma cell lines Y-79, WERI-Rb1, RBL-13 and RBL-15. As revealed by WST-1 and TUNEL assays as well as DAPI and BrdU cell counts, recombinant human TFF3 significantly lowers retinoblastoma cell viability and increases apoptosis levels...
2016: PloS One
https://www.readbyqxmd.com/read/27609758/identification-of-genes-differentially-expressed-in-menstrual-breakdown-and-repair
#12
Premila Paiva, Michelle G Lockhart, Jane E Girling, Moshe Olshansky, Nicole Woodrow, Jennifer L Marino, Martha Hickey, Peter A W Rogers
STUDY QUESTION: Does the changing molecular profile of the endometrium during menstruation correlate with the histological profile of menstruation. SUMMARY ANSWER: We identified several genes not previously associated with menstruation; on Day 2 of menstruation (early-menstruation), processes related to inflammation are predominantly up-regulated and on Day 4 (late-menstruation), the endometrium is predominantly repairing and regenerating. WHAT IS KNOWN ALREADY: Menstruation is induced by progesterone withdrawal at the end of the menstrual cycle and involves endometrial tissue breakdown, regeneration and repair...
September 8, 2016: Molecular Human Reproduction
https://www.readbyqxmd.com/read/27546365/trefoil-factor-3-tff3-from-human-breast-milk-activates-par-2-receptors-of-the-intestinal-epithelial-cells-ht-29-regulating-cytokines-and-defensins
#13
G J Barrera, G Sanchez Tortolero
Trefoil factors are effector molecules in gastrointestinal tract physiology. Each one improves healing of the gastrointestinal tract. Trefoil factors may be grouped into three classes: the gastric peptides (TFF1), spasmolytic peptide (TFF2) and intestinal trefoil factor (TFF3). Significant amounts of TFF3 are present in human breast milk. Previously, we have reported that trefoil factor 3 isolated from human breast milk produces down regulation of cytokines and promotes human beta defensins expression in intestinal epithelial cells...
2016: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/27442005/protein-profiling-of-nasopharyngeal-aspirates-of-hospitalized-and-outpatients-revealed-cytokines-associated-with-severe-influenza-a-h1n1-pdm09-virus-infections-a-pilot-study
#14
Yu Fu, Lana Gaelings, Petri Jalovaara, Laura Kakkola, Mervi T Kinnunen, Hannimari Kallio-Kokko, Miia Valkonen, Anu Kantele, Denis E Kainov
Influenza A viruses (IAV) mutate rapidly and cause seasonal epidemics and occasional pandemics, which result in substantial number of patient visits to the doctors and even hospitalizations. We aimed here to identify inflammatory proteins, which levels correlated to clinical severity of the disease. For this we analysed 102 cytokines and growth factors in human nasopharyngeal aspirate (NPA) samples of 27 hospitalized and 27 outpatients diagnosed with influenza A(H1N1)pdm09 virus infection. We found that the relative levels of monocyte differentiation antigen CD14, lipocalin-2 (LCN2), C-C-motif chemokine 20 (CCL20), CD147, urokinase plasminogen activator surface receptor (uPAR), pro-epidermal growth factor (EGF), trefoil factor 3 (TFF3), and macrophage migration inhibitory factor (MIF) were significantly lower (p<0...
October 2016: Cytokine
https://www.readbyqxmd.com/read/27330011/endometriosis-leads-to-an-increased-trefoil-factor-3-concentration-in-the-peritoneal-cavity-but-does-not-alter-systemic-levels
#15
Diana Henze, Wolf-Dietrich Doecke, Daniela Hornung, Inoncent Agueusop, Oliver von Ahsen, Kathrin Machens, Arndt A Schmitz, Isabella Gashaw
This study analyzed whether trefoil factor 3 (TFF3) is locally elevated and correlated with common biomarkers and inflammatory processes in endometriosis. Peritoneal fluid (PF) was obtained from 50 women and serum from 124 women with or without endometriosis. Experimental endometriosis was induced in female C57BL/6 mice by syngeneic transplantation of uterine tissue to the abdominal wall. Levels of TFF3 in PF of women with endometriosis were significantly increased (P < .05) and correlated with local levels of known biomarkers for endometriosis: cancer antigen (CA) 125, CA-19-9, interleukin 8, monocyte chemotactic protein 1, and matrix metalloproteinase 7...
June 20, 2016: Reproductive Sciences
https://www.readbyqxmd.com/read/27282818/mtor-signalling-in-the-nucleus-accumbens-shell-is-critical-for-augmented-effect-of-tff3-on-behavioural-response-to-cocaine
#16
Yi-Xiao Luo, Hua Han, Juan Shao, Yuan Gao, Xi Yin, Wei-Li Zhu, Ying Han, Hai-Shui Shi
Neuropeptides play important roles in modulating the rewarding value of abused drugs. Trefoil factor 3 (TFF3) was recently reported to modulate withdrawal syndrome of morphine, but the effects of TFF3 on the cocaine-induced behavioral changes are still elusive. In the present study, cocaine-induced hyperlocomotion and conditioned place preference (CPP) rat paradigms were provided to investigate the role of TFF3 in the reward response to cocaine. High-performance liquid chromatography (HPLC) analysis was used to analyse the dopamine concentration...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27262626/trefoil-factor-3-related-to-gastrointestinal-failure-in-pediatric-critical-illness
#17
M-J Ma, B Han, S-Q Xu
BACKGROUND: To determine the relationship between the serum concentration of trefoil factor 3 (TFF3) and gastrointestinal failure (GIF) in pediatric critical illness in order to provide knowledge for disease management. MATERIALS AND METHODS: We enrolled 137 cases and divided them into three groups, including a control group (group A), critical illness without GIF (group B), and critical illness with GIF (group C). The serum TFF3 concentration was determined by ELISA and compared among the groups...
July 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/27229483/arhgap17-a-rhogtpase-activating-protein-regulates-mucosal-and-epithelial-barrier-function-in-the-mouse-colon
#18
So-Young Lee, Hwain Kim, Kyoungmi Kim, Hyunji Lee, Seungbok Lee, Daekee Lee
Coordinated regulation of the actin cytoskeleton by the Rho GTPase family is required for the maintenance of polarity in epithelial cells as well as for their proliferation and migration. A RhoGTPase-activating protein 17 (Arhgap17) is known to be involved in multiple cellular processes in vitro, including the maintenance of tight junctions and vesicle trafficking. However, the function of Arhgap17 has not been studied in the physiological context. Here, we generated Arhgap17-deficient mice and examined the effect in the epithelial and mucosal barriers of the intestine...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27220894/serum-level-of-trefoil-factor-2-can-predict-the-extent-of-gastric-spasmolytic-polypeptide-expressing-metaplasia-in-the-h-pylori-infected-gastric-cancer-relatives
#19
Hsin-Yu Kuo, Wei-Lun Chang, Yi-Chun Yeh, Yu-Ching Tsai, Chung-Tai Wu, Hsiu-Chi Cheng, Hsiao-Bai Yang, Cheng-Chang Lu, Bor-Shyang Sheu
BACKGROUND & AIMS: Gastric cancer has familial clustering in incidence, and the familial relatives of gastric cancer sufferers are prone to have spasmolytic polypeptide-expressing metaplasia (SPEM), and intestinal metaplasia (IM) after H. pylori infection. This study tested whether serum pepsinogen I/II and trefoil factor family (TFF) proteins can predict SPEM or IM in the H. pylori-infected relatives of patients with gastric cancer. METHODS: We prospectively enrolled 119 H...
May 25, 2016: Helicobacter
https://www.readbyqxmd.com/read/27192909/-construction-and-screening-effective-sequence-of-shrna-targeting-human-trefoil-factor-3
#20
Jingfang Wu, Dongmei Wang, Gang Xue, Yamin Chen, Wenjing Zhang, Jing Zhang, Shaoying Li
OBJECTIVE: Trefoil factor 3 plays a pivot role in oncogenic transformation, growth and metastatic extension of solid tumours besides mucosal protection. We screened the best siRNA sequence targeting human TFF3 by the transient-transfection of the lentiviral mediated shRNA into thyroid carcinoma K1 cells which secrete TFF3 themselves. METHOD: Four siRNA transcription template hairpin structure target potential sites in human TFF3 mRNA sequence(132,170,258 and 537 bp,seperately) were selected and synthesized,as well as one negative shRNA(shRNAC)...
January 2016: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
keyword
keyword
32504
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"