Caragh P Stapleton, Andreas Heinzel, Weihua Guan, Peter J van der Most, Jessica van Setten, Graham M Lord, Brendan J Keating, Ajay K Israni, Martin H de Borst, Stephan J L Bakker, Harold Snieder, Michael E Weale, Florence Delaney, Maria P Hernandez-Fuentes, Roman Reindl-Schwaighofer, Rainer Oberbauer, Pamala A Jacobson, Patrick B Mark, Fiona A Chapman, Paul J Phelan, Claire Kennedy, Donal Sexton, Susan Murray, Alan Jardine, Jamie P Traynor, Amy Jayne McKnight, Alexander P Maxwell, Laura J Smyth, William S Oetting, Arthur J Matas, Roslyn B Mannon, David P Schladt, David N Iklé, Gianpiero L Cavalleri, Peter J Conlon
Genetic variation across the human leukocyte antigen loci is known to influence renal-transplant outcome. However, the impact of genetic variation beyond the human leukocyte antigen loci is less clear. We tested the association of common genetic variation and clinical characteristics, from both the donor and recipient, with posttransplant eGFR at different time-points, out to 5 years posttransplantation. We conducted GWAS meta-analyses across 10 844 donors and recipients from five European ancestry cohorts...
August 2019: American Journal of Transplantation