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renal kidney scope

Subramanian Vaidyanathan, Azi Samsudin, Gurpreet Singh, Peter L Hughes, Bakul M Soni, Fahed Selmi
INTRODUCTION: Paraplegic patients are at greater risk of developing complications following ureteroscopic lithotripsy because of urine infection associated with neuropathic bladder, difficulties in access due to altered anatomy of urinary bladder and urethra, spinal curvature, spasticity, and contractures. We report the occurrence of large subcapsular hematoma following ureteroscopy and discuss lessons we learn from this case. CASE REPORT: A 48-year-old male patient with spina bifida underwent ureteroscopy with laser lithotripsy and ureteric stenting for left ureteric stone and staghorn calculus with hydronephrosis; laser lithotripsy was repeated after 3 months; both procedures were performed by a senior urologist and did not result in any complications...
2016: International Medical Case Reports Journal
Ł Czyżewski, J Wyzgał, E Czyżewska, A Kurowski, J Sierdziński, A Łabuś, Z Truszewski, Ł Szarpak
BACKGROUND: Monitoring of the function of the implanted kidney in renal transplant recipients (RTRs) is one of the superior elements of adequate therapeutic actions. The aim of this study was to assess the conventional and unconventional factors affecting the estimated glomerular filtration rate (eGFR) with the Modification of Diet in Renal Disease (MDRD), Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), and Cockcroft-Gault (C-G) formulas among the RTRs. METHODS: The study included 144 RTRs (mean age 52 years)...
June 2016: Transplantation Proceedings
Huiying Sun, Kaizhong Wang, Haiyan Wei, Zhe Li, Hui Zhao
: Melamine (Mel) is used widely as a basic organic chemical intermediate in several products. Within the last 10 years there have been two high-profile Mel exposures that caused toxicological concern, especially regarding food adulteration. OBJECTIVE: This study aimed to determine the toxicity of Mel and one of its homologs, cyanuric acid (Cya), in vitro and in vivo. MATERIALS AND METHODS: The IC50 of Mel and Cya was determined by the MTT assay in NRK-52E and 293T cell lines...
July 17, 2016: Toxicology Mechanisms and Methods
Hilary M Miller, Allison Tong, David J Tunnicliffe, Denise Campbell, Jule Pinter, Robert J Commons, Eugene Athan, Jonathan C Craig, Nicole Gilroy, Julianne Green, Belinda Henderson, Martin Howell, Rhonda L Stuart, Carolyn van Eps, Muh Geot Wong, Janak de Zoysa, Meg J Jardine
Introduction The integration of patient and caregiver input into guideline development can help to ensure that clinical care addresses patient expectations, priorities, and needs. We aimed to identify topics and outcomes salient to patients and caregivers for inclusion in the Kidney Health Australia Caring for Australasians with Renal Impairment (KHA-CARI) clinical practice guideline on the screening and management of infectious microorganisms in hemodialysis units. Methods A facilitated workshop was conducted with 11 participants (patients [n = 8], caregivers [n = 3])...
July 8, 2016: Hemodialysis International
Neville R Dossabhoy, Bhupinder Sangha, Mihály B Tapolyai, Tibor Fülöp
BACKGROUND: Removal of tunneled dialysis catheters (TDC) usually occurs in dedicated procedure suites and is performed relatively rarely at the bedside. Scarce evidence exists in the literature to assess the safety and success of this procedure when performed during supervised academic training. PATIENTS AND METHODS: We conducted a retrospective chart review of all TDC removals performed on an outpatient basis by nephrology fellows under faculty supervision during a 5-year period at an academic Veterans Affairs Medical Center...
July 12, 2016: Journal of Vascular Access
Aashish Sharma, Jose J Zaragoza, Gianluca Villa, Leonardo C Ribeiro, Renhua Lu, Marco Sartori, Elena Faggiana, Massimo de Cal, Grazia M Virzi, Valentina Corradi, Alessandra Brocca, Faeq Husain-Syed, Alessandra Brendolan, Claudio Ronco
BACKGROUND: Renal function reserve (RFR) describes the capacity of the kidney to increase glomerular filtration rate (GFR) in response to physiological or pathological stimuli. The scope of our study was to evaluate the optimal level of stimulation using different doses of protein load (PL) for a standard renal stress test (RST). METHODS: 18 young healthy individuals were given sessions of PL with 1 and 2 g/kg body weight. Endogenous creatinine clearance was calculated...
July 2016: Clinical Nephrology
Stephanie Thompson, Alex Clark, Anita Molzahn, Scott Klarenbach, Marcello Tonelli
BACKGROUND: For people with end-stage kidney disease on hemodialysis, exercise during the dialysis treatment (intradialytic exercise) may promote exercise adherence and enhance aspects of the dialysis treatment. However, intradialytic exercise programs are complex and how to adapt program components to local context so that the program is more likely to attain its intended health outcomes have not been well described. To increase the uptake of exercise in clinical practice, more evidence is needed on how contextual factors influence the program's impact...
2016: Systematic Reviews
Silvia Proietti, Laurian Dragos, Wilson Molina, Steeve Doizi, Guido Giusti, Olivier Traxer
PURPOSE: To evaluate LithoVue, the new single-use digital flexible ureteroscope, in a human cadaveric model and compare it with a nondisposable fiber optic and digital flexible ureteroscopes. MATERIALS AND METHODS: LithoVue, a conventional fiber optic, and digital flexible ureteroscopes were each tested in four renal units of recently deceased female cadavers by three surgeons. The following parameters were analyzed: accessibility to the kidney and navigation of the entire collecting system with and without ureteral access sheath (UAS), lower pole access measuring the deflection of the ureteroscope with the working channel empty, and with inside two different baskets and laser fibers...
June 2016: Journal of Endourology
Daljit K Hothi, Lynsey Stronach, Kate Sinnott
Pediatric home hemodialysis is infrequently performed despite a growing need globally among patients with end-stage renal disease who do not have immediate access to a kidney transplant. In this review, we expand the scope of the Implementing Hemodialysis in the Home website and associated supplement published previously in Hemodialysis International and offer information tailored to the pediatric population. We describe the experience and outcomes of centers managing pediatric patients, and offer recommendations and practical tools to assist clinicians in providing quotidian dialysis for children, including infrastructural and staffing needs, equipment and prescriptions, and patient selection and training...
July 2016: Hemodialysis International
Michelle Hladunewich, Dori Schatell
Pregnancy in women with end stage renal disease on renal replacement therapy is uncommon due to the physiologic changes associated with renal failure as well as the complexities and risk involved in managing these patients. As most of these women had long periods of illness with chronic kidney disease, the effects of their chronic illness together with the current societal trends to delay child bearing to a more advanced maternal age can hamper fertility. For those able to conceive, intensified hemodialysis (HD), through longer and/or more frequent dialysis sessions, offers improved maternal and neonatal outcomes...
July 2016: Hemodialysis International
Matthew A Ladda, Kerry B Goralski
CKD affects a significant proportion of the world's population, and the prevalence of CKD is increasing. Standard practice currently is to adjust the dose of renally eliminated medications as kidney function declines in effort to prevent adverse drug reactions. It is increasingly becoming recognized that CKD also impacts nonrenal clearance mechanisms such as hepatic and intestinal cytochrome P450 (CYP) enzymes and drug transport proteins, the latter of which is beyond the scope of this review. CYPs are responsible for the metabolism of many clinically used drugs...
March 2016: Advances in Chronic Kidney Disease
Jeremie M Lever, Ravindra Boddu, James F George, Anupam Agarwal
SIGNIFICANCE: Acute kidney injury (AKI) and chronic kidney disease (CKD) represent a considerable burden in healthcare. The heme oxygenase (HO) system plays an important role in regulating oxidative stress and is protective in a variety of human and animal models of kidney disease. Preclinical studies of the HO system have led to the development of several clinical trials targeting the enzyme or its products. RECENT ADVANCES: Connection of HO, ferritin, and other proteins involved in iron regulation has provided important insight into mechanisms of damage in AKI...
July 20, 2016: Antioxidants & Redox Signaling
Anna Francis, Madeleine Didsbury, Wai H Lim, Siah Kim, Sarah White, Jonathan C Craig, Germaine Wong
BACKGROUND: Low socioeconomic status (SES) and geographic disparity have been associated with worse outcomes and poorer access to pre-emptive transplantation in the adult end-stage kidney disease (ESKD) population, but little is known about their impact in children with ESKD. The aim of our study was to determine whether access to pre-emptive transplantation and transplant outcomes differ according to SES and geographic remoteness in Australia. METHODS: Using data from the Australia and New Zealand Dialysis and Transplant Registry (1993-2012), we compared access to pre-emptive transplantation, the risk of acute rejection and graft failure, based on SES and geographic remoteness among Australian children with ESKD (≤ 18 years), using adjusted logistic and Cox proportional hazard modelling...
June 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Richard J MacIsaac, Elif I Ekinci, Erosha Premaratne, Zhong X Lu, Jas-Mine Seah, Yue Li, Ray Boston, Glenn M Ward, George Jerums
BACKGROUND: Our hypothesis was that both the Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) and Modification of Diet in Renal Disease (MDRD) equations would underestimate directly measured GFR (mGFR) to a similar extent in people with diabetes and preserved renal function. METHODS: In a cross-sectional study, bias (eGFR - mGFR) was compared for the CKD-EPI and MDRD equations, after stratification for mGFR levels. We also examined the ability of the CKD-EPI compared with the MDRD equation to correctly classify subjects to various CKD stages...
2015: BMC Nephrology
Aijaz Gundroo, Mareena Zachariah, Neeraj Singh, Rajeev Sharma
PURPOSE OF REVIEW: Alemtuzumab (Campath) usage as a preconditioning agent in kidney transplantation has gained considerable interest in the recent future. Alemtuzumab is currently available only by special request from Sanofi through its Campath distribution program. It is restricted to transplant programs with prior and continued experience with the agent. There may be a resurgence of interest for the utilization of this agent because of its ease of administration, and less cost and comparable or improved outcome in comparison to other induction agents...
December 2015: Current Opinion in Organ Transplantation
Patricia D Wilson
INTRODUCTION: Polycystic kidney disease (PKD) is a common genetic disease in which renal enlargement and loss of function is caused by progressive expansion of tubular cysts. To reverse the detrimental effects of PKD gene mutation(s) and to slow cystic expansion, new drug therapies are required. AREAS COVERED: The underlying cell biology leading to identification of molecular targets for PKD is reviewed. Specific focus is on studies published at the early pre-clinical level...
2016: Expert Opinion on Therapeutic Targets
Delicia Gentille Lorente, Jorge Gentille Lorente, Teresa Salvadó Usach
OBJECTIVE: To assess the prevalence of kidney failure in patients from a primary care centre in a basic healthcare district with laboratory availability allowing serum creatinine measurements. DESIGN: An observational descriptive cross-sectional study. DATA SOURCES: A basic healthcare district serving 23,807 people aged ≥ 18 years. RESULTS: Prevalence of kidney failure among 17,240 patients having at least one laboratory measurement available was 8...
2015: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
Yolanda W Ng, Manpreet Singh, Minnie M Sarwal
Kidney transplant is the preferred treatment of pediatric end-stage renal disease. One of the most challenging aspects of pediatric kidney transplant is the prevention and treatment of antibody-mediated rejection (ABMR), which is one of the main causes of graft dysfunction and early graft loss. Most challenges are similar to those faced in adult kidney transplants; however, factors unique to the pediatric realm include naivety of the immune system and the small number of studies and randomized controlled trials available when considering pharmacological treatment options...
April 2015: Drugs
Isabelle Binet
No abstract text is available yet for this article.
May 2015: Transplant International: Official Journal of the European Society for Organ Transplantation
Maria C Haller, Sabine N van der Veer, Evi V Nagler, Charlie Tomson, Andrew Lewington, Brenda R Hemmelgarn, Martin Gallagher, Michael Rocco, Gregorio Obrador, Raymond Vanholder, Jonathan C Craig, Wim van Biesen
BACKGROUND: Worldwide, several bodies produce renal guidelines, potentially leading to duplication of effort while other topics may remain uncovered. A collaborative work plan could improve efficiency and impact, but requires a common approved methodology. The aim of this study was to identify organizational and methodological similarities and differences among seven major renal guideline bodies to identify methodological barriers to a collaborative effort. METHODS: An electronic 62-item survey with questions based on the Institute of Medicine standards for guidelines was completed by representatives of seven major organizations producing renal guidelines: the Canadian Society of Nephrology (CSN), European Renal Best Practice (ERBP), Kidney Disease Improving Global Outcome (KDIGO), Kidney Health Australia-Caring for Australians with Renal Insufficiency (KHA-CARI), Kidney Disease Outcome Quality Initiative (KDOQI), Sociedad Latino-Americano de Nefrologia e Hipertension (SLANH) and United Kingdom Renal Association (UK-RA)...
July 2015: Nephrology, Dialysis, Transplantation
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