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https://read.qxmd.com/read/125649/enzymatic-oxidation-and-reduction-of-c19-delta5-3beta-hydroxysteroids-by-hepatic-microsomes-v-testosterone-as-a-neonatal-determinant-in-rats-of-the-7-and-16alpha-hydroxylation-and-reduction-of-3beta-hydroxyandrost-5-en-17-one-dha
#21
JOURNAL ARTICLE
T Tabei, W L Heinrichs
The oxido-reductive metabolism of [14C]dehydroepiandrosterone (DHA) by hepatic microsomes from 40- or 70-day-old rats of either sex castrated neonatally has been compared after several treatment regimens with testosterone propionate (TP). The low transformation rate of DHA to 16-oxygenated metabolites produced by neonatal orchiectomy (0.09 +/- 0.04 nmoles min-1 mg-1), was not restored in 70-day-old males by either neonatal or pubertal treatment with TP. The rates were only partially restored (0.74 +/- 0.44) toward nromal adult levels (1...
August 1975: Endocrinology
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