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https://www.readbyqxmd.com/read/29782878/the-ubiquitin-protein-ligase-e6ap-ube3a-supports-early-encephalomyocarditis-virus-replication
#1
Marybeth Carmody, Joshua T Zimmer, Camille H Cushman, Thao Nguyen, T Glen Lawson
Many viruses make use of, and even direct, the ubiquitin-proteasome system to facilitate the generation of a cellular environment favorable for virus replication, while host cells use selected protein ubiquitylation pathways for antiviral defense. Relatively little information has been acquired, however, regarding the extent to which protein ubiquitylation determines the replication success of picornaviruses. Here we report that the ubiquitin-protein ligase E6AP/UBE3A, recently shown to be a participant in encephalomyocarditis virus (EMCV) 3C protease concentration regulation, also facilitates the early stages of EMCV replication, probably by a mechanism that does not involve 3C protease ubiquitylation...
May 18, 2018: Virus Research
https://www.readbyqxmd.com/read/29781098/pet-imaging-of-the-influence-of-physiological-and-pathological-%C3%AE-synuclein-on-dopaminergic-and-serotonergic-neurotransmission-in-mouse-models
#2
Elise Levigoureux, Caroline Bouillot, Thierry Baron, Luc Zimmer, Sophie Lancelot
AIMS: Alpha-synuclein (α-syn) aggregation is a neuropathological hallmark of neurodegenerative synucleinopathies. This in vivo study explored glucose metabolism and dopaminergic and serotoninergic neurotransmission in KO α-syn, wild-type mice and an accelerated murine model of synucleinopathy (M83). METHODS: MicroPET acquisitions were performed in all animals aged 5-6 months using five radiotracers exploring brain glucose metabolism ([18 F]FDG), dopamine neurotransmission ([11 C]raclopride, [11 C]PE2I) and serotonin neurotransmission ([18 F]MPPF, [11 C]DASB)...
May 20, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29780553/reactivity-enhancement-of-a-diphosphene-by-reversible-n-heterocyclic-carbene-coordination
#3
Debabrata Dhara, Pankaj Kalita, Subhadip Mondal, Ramakirushnan Suriya Narayanan, Kaustubh R Mote, Volker Huch, Michael Zimmer, Cem B Yildiz, David Scheschkewitz, Vadapalli Chandrasekhar, Anukul Jana
Diphosphene TerMes P = PTerMes ( 1 ; TerMes = 2,6-Mes2 C6 H3 ; Mes = 2,4,6-Me3 C6 H2 ) and NHCMe4 2 (NHCMe4 = 1,3,4,5-tetramethylimidazol-2-ylidene) exist in an equilibrium mixture with the NHCMe4 -coordinated diphosphene 3 . While uncoordinated 1 is inert to hydrolysis, the NHC adduct 3 readily undergoes hydrolysis to afford a phosphino-substituted phosphine oxide with the liberation of NHCMe4 . On this basis, conditions suitable for the catalytic use of NHCMe4 were identified. Similarly, while the hydrogenation of free diphosphene 1 with H3 N·BH3 is very slow, 3 reacts instantaneously with H3 N·BH3 at room temperature to afford a dihydrodiphosphane...
May 14, 2018: Chemical Science
https://www.readbyqxmd.com/read/29767270/no-correlation-between-rotation-of-femoral-components-in-the-transverse-plane-and-clinical-outcome-after-total-knee-arthroplasty
#4
Roland Becker, Katharina Bäker, Hagen Hommel, Manfred Bernard, Sebastian Kopf
PURPOSE: It was hypothesized that malrotation of femoral component in total knee arthroplasty (TKA) will significantly impact clinical outcome. METHODS: Eighty-eight consecutive patients with primary osteoarthritis of the knee were prospectively evaluated. They received a cemented posterior stabilized TKA (NexGen, Zimmer/Biomet® Inc., Warsaw, IN, USA). The femoral component was placed in 3° of external rotation referenced to the posterior condylar line. Postoperatively, a CT scan was performed to evaluate rotation of femoral component in the transverse plane...
May 16, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29765788/early-pulmonary-interstitial-emphysema-in-preterm-neonates-respiratory-management-and-case-report-in-nonventilated-very-low-birth-weight-twins
#5
Judith Gronbach, Harald Ehrhardt, Klaus-Peter Zimmer, Markus Waitz
Early pulmonary interstitial emphysema in extreme preterm neonates is closely linked with respiratory distress syndrome and exposure to mechanical ventilation. In severe cases, maintaining adequate gas exchange aiming to avoid further lung damage and other neonatal morbidities associated with systemic/pulmonary hypoperfusion, prolonged hypoxia, and respiratory acidosis can be challenging and requires in-depth knowledge into the pathophysiology of the disease. Herein, we report on very low birth weight twins who developed early pulmonary interstitial emphysema during noninvasive respiratory support...
April 2018: American Journal of Perinatology Reports
https://www.readbyqxmd.com/read/29764010/the-tenting-into-an-external-snare-technique-a-novel-singlechannel-traction-approach-for-endoscopic-resection-of-difficultto-access-lesions-using-a-wide-necked-cap
#6
https://www.readbyqxmd.com/read/29762383/starch-tolerance-and-the-short-bowel
#7
Jan de Laffolie, Hassan Y Naim, Silvia Rudloff, Klaus-Peter Zimmer
Short bowel syndrome with intestinal failure is a rare disease with a massive impairment in quality of life, requiring a multidisciplinary team approach to medical, surgical, and nutritional therapy. Current pharmacological and surgical therapeutic options are limited; an important cornerstone is enteral and parenteral nutrition. The changed physiology of carbohydrate digestion plays a major role in the adaptation process and can be a target for specific enteral nutrition interventions. An important prognostic factor is the preservation of at least portions of the colon in continuity with small bowel...
June 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29762090/alzheimer-disease-and-mild-cognitive-impairment-integrated-pulsed-arterial-spin-labeling-mri-and-18-f-fdg-pet
#8
Isabelle Riederer, Karl Peter Bohn, Christine Preibisch, Eva Wiedemann, Claus Zimmer, Panagiotis Alexopoulos, Stefan Förster
Purpose To compare PET/MR hypoperfusion and hypometabolism in patients with Alzheimer disease (AD) and mild cognitive impairment (MCI) compared with healthy control (HC) participants. Materials and Methods Maps of cerebral blood flow (CBF; pulsed arterial spin-labeling [ASL] MRI), glucose metabolism (fluorine 18 [18 F] fluorodeoxyglucose [FDG] PET), and gray matter (GM) volume (structural T1-weighted MRI) were calculated from integrated PET/MR data in 45 patients with AD (mean age, 69 years ± 9 [standard deviation]; age range, 51-89 years), 20 patients with MCI (mean age, 64 years ± 10; age range, 45-82 years), and 11 HC participants (mean age, 65 years ± 8; age range, 54-80 years) between 2011 and 2014...
May 15, 2018: Radiology
https://www.readbyqxmd.com/read/29758333/hepatitis-b-virus-specific-t-cell-responses-after-stopping-nucleos-t-ide-analogue-therapy-in-hbeag-negative-chronic-hepatitis-b
#9
Franziska Rinker, Christine L Zimmer, Christoph Höner Zu Siederdissen, Michael P Manns, Anke R M Kraft, Heiner Wedemeyer, Niklas K Björkström, Markus Cornberg
BACKGROUND AND AIMS: Treatment with nucleos(t)ide analogues (NA) leads to HBV DNA suppression in most patients with chronic hepatitis B (CHB), but HBsAg loss rates are low. Upon NA discontinuation, HBV DNA can return rapidly with ensuing ALT flares and induction of cytokines. Several studies reported higher HBsAg loss rates after stopping therapy, but at present, it is unclear if cell-mediated immune responses are altered after treatment discontinuation. The aim of this study was to characterise T cell responses during the early phase of virological relapse following discontinuation of NA therapy in HBeAg-negative patients...
May 11, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29756805/age-related-changes-in-working-memory-age-affects-relational-but-not-conjunctive-feature-binding
#10
Alexander Kirmsse, Hubert D Zimmer, Ullrich K H Ecker
In contrast to long-term memory, age-related association deficits in working memory are found only inconsistently. The authors hypothesized that type of binding is critical for the occurrence of such deficits. Relational binding abilities (associating separate visual units) should degrade with age, whereas more automatic conjunctive binding abilities (associating features within an object) should not. They contrasted associative memory and item memory using a change-detection task with colors and shapes in younger (18-33 years) and older (64-82 years) healthy adults...
May 2018: Psychology and Aging
https://www.readbyqxmd.com/read/29753641/consistency-of-normalized-cerebral-blood-volume-values-in-glioblastoma-using-different-leakage-correction-algorithms-on-dynamic-susceptibility-contrast-magnetic-resonance-imaging-data-without-and-with-prebolus
#11
Dennis Hedderich, Anne Kluge, Thomas Pyka, Claus Zimmer, Jan S Kirschke, Benedikt Wiestler, Christine Preibisch
BACKGROUND AND PURPOSE: Several leakage correction algorithms for dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI)-based cerebral blood volume (CBV) measurement have been proposed, and combination with a preload of contrast agent is generally recommended. A single bolus application scheme would largely simplify and facilitate standardized clinical applications, while reducing contrast agent (CA) dose. The aim of this study was, therefore, to investigate whether appropriate leakage correction redundantizes prebolus application by comparing normalized DSC-based CBV (nCBV) measures of two consecutive CA boli...
May 10, 2018: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/29750473/dermatologische-rezepturen-in-deutschland-relevanz-f%C3%A3-r-die-versorgung
#12
Petra Staubach, Stefan Salzmann, Adriane Peveling-Oberhag, Veronika Weyer, Sebastian Zimmer, Gabriele Gradl, Berenice M Lang
No abstract text is available yet for this article.
May 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29750454/extemporaneous-formulations-in-germany-relevance-for-everyday-clinical-practice
#13
Petra Staubach, Stefan Salzmann, Adriane Peveling-Oberhag, Veronika Weyer, Sebastian Zimmer, Gabriele Gradl, Berenice M Lang
BACKGROUND: Extemporaneous formulations broaden the spectrum of therapeutic options for topical treatment in particular and thus improve patient care. The latest amendment to the Regulation on the Operation of Pharmacies issued in 2012 brought about changes in prescribing and manufacturing practices. The aim of the present study was to assess the relevance of extemporaneous formulations in everyday clinical practice. METHODS: We used data from the German Institute for Drug Use Evaluation (DAPI) to analyze the prescribing practice for compounded preparations in Germany between the fourth quarter of 2011 and the third quarter of 2014...
May 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29748186/dicer-in-macrophages-prevents-atherosclerosis-by-promoting-mitochondrial-oxidative-metabolism
#14
Yuanyuan Wei, Judit Corbalán-Campos, Rashmi Gurung, Lucia Natarelli, Mengyu Zhu, Nicole Exner, Florian Erhard, Franziska Greulich, Claudia Geißler, N Henriette Uhlenhaut, Ralf Zimmer, Andreas Schober
Background -Alternative macrophage activation, which relies on mitochondrial oxidative metabolism, plays a central role in resolution of inflammation and prevents atherosclerosis. Moreover, macrophages handle large amounts of cholesterol and triglycerides derived from the engulfed modified lipoproteins during atherosclerosis. Although several microRNAs regulate macrophage polarization, the role of microRNA-generating enzyme Dicer in macrophage activation during atherosclerosis is unknown. Methods -To evaluate the role of Dicer in atherosclerosis, Apoe-/- mice with or without macrophage-specific Dicer deletion were fed a high-fat diet for 12 weeks...
May 10, 2018: Circulation
https://www.readbyqxmd.com/read/29747561/similar-radiological-results-with-accelerometer-based-navigation-versus-conventional-technique-in-total-knee-arthroplasty
#15
Ing How Moo, Jerry Yong Qiang Chen, Dickson Hong Him Chau, See Wei Tan, Adrian Cheng Kiang Lau, Yee Sze Teo
BACKGROUND: The Zimmer iASSIST system is an accelerometer-based, portable navigation device for total knee arthroplasty (TKA) that does not require the use of a large console for alignment feedback as required in computer-assisted surgery. The purpose of this study was to determine the accuracy of the accelerometer-based system in component positioning and overall mechanical alignment. METHODS: Two groups of 30 patients each with primary osteoarthritis underwent TKA using either conventional method or Zimmer iASSIST navigation in 2013 was retrospectively studied...
May 2018: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/29746490/clinical-evaluation-of-semi-automatic-open-source-algorithmic-software-segmentation-of-the-mandibular-bone-practical-feasibility-and-assessment-of-a-new-course-of-action
#16
Jürgen Wallner, Kerstin Hochegger, Xiaojun Chen, Irene Mischak, Knut Reinbacher, Mauro Pau, Tomislav Zrnc, Katja Schwenzer-Zimmerer, Wolfgang Zemann, Dieter Schmalstieg, Jan Egger
INTRODUCTION: Computer assisted technologies based on algorithmic software segmentation are an increasing topic of interest in complex surgical cases. However-due to functional instability, time consuming software processes, personnel resources or licensed-based financial costs many segmentation processes are often outsourced from clinical centers to third parties and the industry. Therefore, the aim of this trial was to assess the practical feasibility of an easy available, functional stable and licensed-free segmentation approach to be used in the clinical practice...
2018: PloS One
https://www.readbyqxmd.com/read/29740255/computing-diffusivities-from-particle-models-out-of-equilibrium
#17
Peter Embacher, Nicolas Dirr, Johannes Zimmer, Celia Reina
A new method is proposed to numerically extract the diffusivity of a (typically nonlinear) diffusion equation from underlying stochastic particle systems. The proposed strategy requires the system to be in local equilibrium and have Gaussian fluctuations but it is otherwise allowed to undergo arbitrary out-of-equilibrium evolutions. This could be potentially relevant for particle data obtained from experimental applications. The key idea underlying the method is that finite, yet large, particle systems formally obey stochastic partial differential equations of gradient flow type satisfying a fluctuation-dissipation relation...
April 2018: Proceedings. Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29738596/relatively-high-complication-and-revision-rates-of-the-mayo-%C3%A2-metaphysical-conservative-femoral-stem-in-young-patients
#18
Tal Frenkel Rutenberg, Yaniv Warshevski, Aviram Gold, Nadav Shasha, Nimrod Snir, Ofir Chechik, Oleg Dolkart, Dynai Eilig, Amir Herman, Ehud Rath, Moti Kramer, Michael Drexler
The Mayo metaphysical conservative femoral stem (Zimmer, Warsaw, Indiana) is a wedge-shaped implant designed to transfer loads proximally, reduce femoral destruction, and enable the preservation of bone stock in the proximal femur. Thus, it is a potentially preferred prosthesis for active, non-elderly patients who may require additional future surgeries. This retrospective case study analyzed the outcomes of consecutive patients who underwent total hip replacements with this stem between May 2001 and February 2013...
May 8, 2018: Orthopedics
https://www.readbyqxmd.com/read/29732467/permanent-brain-damage-following-parasuicide-with-severe-insulin-induced-hypoglycaemia
#19
Andreas Holstein, Markus Zimmer, Mathias Rohde, Brian M Frier
No abstract text is available yet for this article.
May 7, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29731246/gdf11-induces-kidney-fibrosis-renal-cell-epithelial-to-mesenchymal-transition-and-kidney-dysfunction-and-failure
#20
Marianne Pons, Leonidas G Koniaris, Sharon M Moe, Juan C Gutierrez, Aurora Esquela-Kerscher, Teresa A Zimmers
BACKGROUND: GDF11 modulates embryonic patterning and kidney organogenesis. Herein, we sought to define GDF11 function in the adult kidney and in renal diseases. METHODS: In vitro renal cell lines, genetic, and murine in vivo renal injury models were examined. RESULTS: Among tissues tested, Gdf11 was highest in normal adult mouse kidney. Expression was increased acutely after 5/6 nephrectomy, ischemia-reperfusion injury, kanamycin toxicity, or unilateral ureteric obstruction...
May 3, 2018: Surgery
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