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https://www.readbyqxmd.com/read/29352959/a-flat-tire-in-the-colon
#1
Vincent Zimmer, Philipp A Schnabel, Frank Lammert
No abstract text is available yet for this article.
January 17, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29346747/sensorimotor-integration-for-decision-making-how-the-worm-steers
#2
Harris S Kaplan, Manuel Zimmer
Animals' movements actively shape their perception and subsequent decision making. In this issue of Neuron, Liu et al. (2018) show how C. elegans nematodes steer toward an odorant: a dedicated interneuron class integrates oscillatory olfactory signals, generated by head swings, with corollary discharge motor signals.
January 17, 2018: Neuron
https://www.readbyqxmd.com/read/29337073/neofunctionalization-of-duplicated-p450-genes-drives-the-evolution-of-insecticide-resistance-in-the-brown-planthopper
#3
Christoph T Zimmer, William T Garrood, Kumar Saurabh Singh, Emma Randall, Bettina Lueke, Oliver Gutbrod, Svend Matthiesen, Maxie Kohler, Ralf Nauen, T G Emyr Davies, Chris Bass
Gene duplication is a major source of genetic variation that has been shown to underpin the evolution of a wide range of adaptive traits [1, 2]. For example, duplication or amplification of genes encoding detoxification enzymes has been shown to play an important role in the evolution of insecticide resistance [3-5]. In this context, gene duplication performs an adaptive function as a result of its effects on gene dosage and not as a source of functional novelty [3, 6-8]. Here, we show that duplication and neofunctionalization of a cytochrome P450, CYP6ER1, led to the evolution of insecticide resistance in the brown planthopper...
January 4, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29335749/diversity-among-pou-transcription-factors-in-chromatin-recognition-and-cell-fate-reprogramming
#4
REVIEW
Vikas Malik, Dennis Zimmer, Ralf Jauch
The POU (Pit-Oct-Unc) protein family is an evolutionary ancient group of transcription factors (TFs) that bind specific DNA sequences to direct gene expression programs. The fundamental importance of POU TFs to orchestrate embryonic development and to direct cellular fate decisions is well established, but the molecular basis for this activity is insufficiently understood. POU TFs possess a bipartite 'two-in-one' DNA binding domain consisting of two independently folding structural units connected by a poorly conserved and flexible linker...
January 15, 2018: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29335483/pilot-study-to-assess-visualization-and-therapy-of-inflammatory-mechanisms-after-vessel-reopening-in-a-mouse-stroke-model
#5
Ebba Beller, Laura Reuter, Anne Kluge, Christine Preibisch, Ute Lindauer, Alexei Bogdanov, Friederike Lämmer, Claire Delbridge, Kaspar Matiasek, Benedikt J Schwaiger, Tobias Boeckh-Behrens, Claus Zimmer, Alexandra S Gersing
After reperfusion therapy in stroke patients secondary inflammatory processes may increase cerebral damage. In this pilot study, effects of anti-inflammatory therapy were assessed in a middle cerebral artery occlusion (MCAO) mouse model after reperfusion. 1 hour after MCAO, the artery was reopened and tacrolimus or NaCl were administered intra-arterially. Perfusion-weighted (PWI) and diffusion-weighted images (DWI) were obtained by MRI during MCAO. DWI, T2- and T1-weighted images with and without Bis-5HT-DTPA administration were obtained 24 hours after MCAO...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29329910/the-effects-of-exercise-intensity-and-post-exercise-recovery-time-on-cortical-activation-as-revealed-by-eeg-alpha-peak-frequency
#6
B Gutmann, P Zimmer, T Hülsdünker, J Lefebvre, S Binnebößel, M Oberste, W Bloch, H K Strüder, A Mierau
Acute physical exercise (APE) induces an increase in the individual alpha peak frequency (iAPF), a cortical parameter associated with neural information processing speed. The aim of this study was to further scrutinize the influence of different APE intensities on post-exercise iAPF as well as its time course after exercise cessation. 95 healthy young (18-35 years) subjects participated in two randomized controlled experiments (EX1 and EX2). In EX1, all participants completed a graded exercise test (GXT) until exhaustion and were randomly allocated into different delay groups (immediately 0, 30, 60 and 90 minutes after GXT)...
January 9, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29329302/phylogeography-and-conservation-genetics-of-the-rare-and-relict-bretschneidera-sinensis-akaniaceae
#7
Mei-Na Wang, Lei Duan, Qi Qiao, Zheng-Feng Wang, Elizabeth A Zimmer, Zhong-Chao Li, Hong-Feng Chen
Bretschneidera sinensis, a class-I protected wild plant in China, is a relic of the ancient Tertiary tropical flora endemic to Asia. However, little is known about its genetics and phylogeography. To elucidate the current phylogeographic patterns and infer the historical population dynamics of B. sinensis, and to make recommendations for its conservation, three non-coding regions of chloroplast DNA (trnQ-rps16, rps8-rps11, and trnT-trnL) were amplified and sequenced across 256 individuals from 23 populations of B...
2018: PloS One
https://www.readbyqxmd.com/read/29322270/recent-developments-in-evaluation-and-treatment-of-lateral-patellar-instability
#8
REVIEW
Alexander Zimmerer, Christian Sobau, Peter Balcarek
Recent years have been characterized by an ongoing increase in knowledge about the different conditions associated with lateral patellar instability. This increase in knowledge provides differentiated approaches to the various pathologies of the patellofemoral joint. Though current guidelines consider medial patellofemoral ligament (MPFL) reconstruction the basic treatment for the unstable patella, medial soft tissue-stabilizing procedures should not be interpreted as stand-alone procedures in every case. The influence of different anatomical factors leading to patellar instability, as well as their impact on clinical outcome measures, is becoming increasingly apparent and deserves further attention...
January 10, 2018: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/29322233/high-isotropic-resolution-t2-mapping-of-the-lumbosacral-plexus-with-t2-prepared-3d-turbo-spin-echo
#9
Nico Sollmann, Dominik Weidlich, Barbara Cervantes, Elisabeth Klupp, Carl Ganter, Hendrik Kooijman, Ernst J Rummeny, Claus Zimmer, Jan S Kirschke, Dimitrios C Karampinos
PURPOSE: Isotropic high-resolution three-dimensional (3D) magnetic resonance neurography (MRN) is increasingly used to depict even small and highly oblique nerves of the lumbosacral plexus (LSP). The present study introduces a T2 mapping sequence (T2-prepared 3D turbo spin echo) that is B1-insensitive and enables quantitative assessment of LSP nerves. METHODS: In this study 15 healthy subjects (mean age 28.5 ± 3.8 years) underwent 3 T MRN of the LSP area three times...
January 10, 2018: Clinical Neuroradiology
https://www.readbyqxmd.com/read/29320481/architecture-of-a-channel-forming-o-antigen-polysaccharide-abc-transporter
#10
Yunchen Bi, Evan Mann, Chris Whitfield, Jochen Zimmer
O-antigens are cell surface polysaccharides of many Gram-negative pathogens that aid in escaping innate immune responses. A widespread O-antigen biosynthesis mechanism involves the synthesis of the lipid-anchored polymer on the cytosolic face of the inner membrane, followed by transport to the periplasmic side where it is ligated to the lipid A core to complete a lipopolysaccharide molecule. In this pathway, transport to the periplasm is mediated by an ATP-binding cassette (ABC) transporter, called Wzm-Wzt...
January 10, 2018: Nature
https://www.readbyqxmd.com/read/29319895/the-onset-of-fretting-at-the-head-stem-connection-in-hip-arthroplasty-is-affected-by-head-material-and-trunnion-design-under-simulated-corrosion-conditions
#11
Fiachra E Rowan, Amanda Wach, Timothy M Wright, Douglas E Padgett
Mechanically assisted crevice corrosion (MACC) is a mechanism for trunnion damage in total hip arthroplasties (THAs). Retrieval studies have shown reduced MACC-related damage for ceramic heads compared with cobalt-chromium (CoCr) heads. We propose that ceramic heads demonstrate fretting at higher cyclic compressive loads than CoCr heads on titanium alloy trunnions in a simulated corrosion model. A closed electrochemical chamber was used to measure fretting current onset loads for two modern titanium alloy trunnions (Zimmer 12/14 and Stryker V-40) in which trunnion failure has been reported...
January 10, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29316801/economic-analysis-of-rapid-multiplex-polymerase-chain-reaction-testing-for-meningitis-encephalitis-in-pediatric-patients
#12
Steve Duff, Rodrigo Hasbun, Christine C Ginocchio, Joan-Miquel Balada-Llasat, Louise Zimmer, Samuel A Bozzette
AIM: We assessed the possible economic impact of a rapid test in pediatric patients with suspected community-acquired meningitis/encephalitis. MATERIALS & METHODS: Modeling simulated diagnosis, clinical decisions, resource use/costs of standard of care (SOC) and two cerebrospinal fluid testing strategies using FilmArray® (FA), a US FDA-cleared system that provides results in approximately 1 h. RESULTS: Pathogens detected by FA caused approximately 75% of cases, 97% of which would be accurately diagnosed with FA...
January 10, 2018: Future Microbiology
https://www.readbyqxmd.com/read/29316343/circulating-monocyte-chemoattractant-protein-1-mcp-1-is-associated-with-cachexia-in-treatment-na%C3%A3-ve-pancreatic-cancer-patients
#13
Erin E Talbert, Heather L Lewis, Matthew R Farren, Mitchell L Ramsey, Jeffery M Chakedis, Priyani Rajasekera, Ericka Haverick, Angela Sarna, Mark Bloomston, Timothy M Pawlik, Teresa A Zimmers, Gregory B Lesinski, Phil A Hart, Mary E Dillhoff, Carl R Schmidt, Denis C Guttridge
BACKGROUND: Cancer-associated wasting, termed cancer cachexia, has a profound effect on the morbidity and mortality of cancer patients but remains difficult to recognize and diagnose. While increases in circulating levels of a number of inflammatory cytokines have been associated with cancer cachexia, these associations were generally made in patients with advanced disease and thus may be associated with disease progression rather than directly with the cachexia syndrome. Thus, we sought to assess potential biomarkers of cancer-induced cachexia in patients with earlier stages of disease...
January 7, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29316108/disilenyl-silylene-reactivity-of-a-cyclotrisilene
#14
David Scheschkewitz, Kinga Leszczyńska, Hui Zhao, Lukas Klemmer, Volker Huch, Michael Zimmer
The highly reactive silicon congeners of cyclopropene, cyclotrisilenes (c-Si₃R₄), typically undergo either π-addition to the Si=Si double bond or σ-insertion into the Si-Si single bond. In contrast, treatment of c-Si₃Tip₄ (Tip = 2,4,6-iPr₃C₆H₂) with styrene and benzil results in ring opening of the three-membered ring to formally yield the [1+2] and [1+4] cycloaddition product of the isomeric disilenyl silylene to the C=C bond and the 1,2-diketone π system, respectively. At elevated temperature, styrene is released from the [1+2] addition product leading to the thermodynamically favored housane species after [2+2] cycloaddition of styrene and c-Si₃Tip₄...
January 5, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29315358/htt-db-new-features-and-updates
#15
Bruno Reis Dotto, Evelise Leis Carvalho, Alexandre Freitas da Silva, Filipe Zimmer Dezordi, Paulo Marcos Pinto, Tulio de Lima Campos, Antonio Mauro Rezende, Gabriel da Luz Wallau
Horizontal Transfer (HT) of genetic material between species is a common phenomenon among Bacteria and Archaea species and several databases are available for information retrieval and data mining. However, little attention has been given to this phenomenon among eukaryotic species mainly due to the lower proportion of these events. In the last years, a vertiginous amount of new HT events involving eukaryotic species was reported in the literature, highlighting the need of a common repository to keep the scientific community up to date and describe overall trends...
January 1, 2018: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/29313542/a-programmable-platform-for-sub-second-multichemical-dynamic-stimulation-and-neuronal-functional-imaging-in-c-elegans
#16
T Rouse, G Aubry, Y Cho, M Zimmer, H Lu
Caenorhabditis elegans (C. elegans) is a prominent model organism in neuroscience, as its small stereotyped nervous system offers unique advantages for studying neuronal circuits at the cellular level. Characterizing temporal dynamics of neuronal circuits is essential to fully understand neuronal processing. Characterization of the temporal dynamics of chemosensory circuits requires a precise and fast method to deliver multiple stimuli and monitor the animal's neuronal activity. Microfluidic platforms have been developed that offer an improved control of chemical delivery compared to manual methods...
January 9, 2018: Lab on a Chip
https://www.readbyqxmd.com/read/29313319/early-experience-with-a-tapered-titanium-porous-plasma-sprayed-stem-with-updated-design
#17
Antonio G Manocchio, Keith R Berend, Michael J Morris, Joanne B Adams, Adolph V Lombardi
INTRODUCTION: The Taperloc® Complete femoral stem (Zimmer Biomet, Warsaw, Indiana) builds on the widespread clinical success of the original Taperloc design used since 1982. Enhancements to the Complete design include a lowered caput-collum-diaphyseal (CCD) angle from 138° to 133° for improved offset, optimized neck taper with polished neck flats to increase range of motion, reduced distal geometry to improve proximal canal fill, and gradual off-loading that is the goal of tapered geometry...
December 22, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/29309041/first-application-of-segmental-trabecular-metal-cones-in-a-custom-made-revision-tumor-prosthesis-of-the-knee-a-technical-note
#18
Roslind Karolina Hackenberg, Jochen Nessler, Dietmar Pierre König
BACKGROUND: Tumor prostheses are established as a standard procedure in tumors of the lower extremities. Septic and aseptic loosening remains the main reason for the failure of tumor prostheses. Due to bone defects, the possibilities of anchoring revision prostheses are limited. Trabecular metal cones are established in prosthetic revision surgery. However, the use of segmental trabecular metal cones in a custom-made tumor revision prosthesis has not yet been described. OBJECTIVE: A 58-year-old patient, who initially received a resection of the distal femur and reconstruction with a tumor prosthesis due to chondrosarcoma, attended our clinic...
December 29, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/29305540/direct-from-blood-culture-disk-diffusion-to-determine-antimicrobial-susceptibility-of-gram-negative-bacteria-preliminary-report-from-the-clinical-and-laboratory-standards-institute-methods-development-and-standardization-working-group
#19
Sukantha Chandrasekaran, April Abbott, Shelley Miller, Barb Zimmer, Mel Weinstein, Lauri Thrupp, John Hejna, Lindsey Walker, Tracy Ammann, Thomas Kirn, Robin Patel, Romney M Humphries
The performance of disk diffusion, using broth from positive blood cultures as inoculum ("direct disk diffusion", dDD), was evaluated for a collection of 20 challenge isolates of Enterobacteriaceae, Acinetobacter baumannii and Pseudomonas aeruginosa. Isolates seeded into human blood were inoculated into BACTEC™ Plus Aerobic/F, VersaTREK REDOX 1 and BacT/ALERT FA Plus bottles and incubated on the respective automated blood culture systems. Disk diffusion results were compared to reference disk diffusion. Categorical agreement (CA) of dDD, after removal of random errors due to natural MIC variation, was 87...
January 5, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29305101/development-of-a-hybrid-computational-experimental-framework-for-evaluation-of-damage-mechanisms-of-a-linked-semiconstrained-total-elbow-system
#20
Danial Sharifi Kia, Ryan Willing
BACKGROUND: Long-term durability of total elbow arthroplasty (TEA) is a concern, and bearing wear or excessive deformations may necessitate early revision. The current study used experimental wear testing and computational finite element modeling to develop a hybrid computational and experimental framework for the evaluation of TEA damage mechanisms. METHODS: Three Coonrad-Morrey (Zimmer-Biomet Inc., Warsaw, IN, USA) TEA implants were used for experimental wear testing for 200,000  cycles...
January 2, 2018: Journal of Shoulder and Elbow Surgery
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