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https://www.readbyqxmd.com/read/28431254/hypothalamic-agrp-neurons-drive-stereotypic-behaviors-beyond-feeding
#1
Marcelo O Dietrich, Marcelo R Zimmer, Jeremy Bober, Tamas L Horvath
No abstract text is available yet for this article.
April 20, 2017: Cell
https://www.readbyqxmd.com/read/28423519/vitamin-d-and-vdr-in-cancer-cachexia-and-muscle-regeneration
#2
Andrea Camperi, Fabrizio Pin, Domiziana Costamagna, Fabio Penna, Maria Lopez Menduina, Zaira Aversa, Teresa Zimmers, Roberto Verzaro, Raffaella Fittipaldi, Giuseppina Caretti, Francesco Maria Baccino, Maurizio Muscaritoli, Paola Costelli
Low circulating levels of vitamin D were associated with decreased muscle strength and physical performance. Along this line, the present study was aimed to investigate: i) the therapeutic potential of vitamin D in cancer-induced muscle wasting; ii) the mechanisms by which vitamin D affects muscle phenotype in tumor-bearing animals.Rats bearing the AH130 hepatoma showed decreased circulating vitamin D compared to control rats, while muscle vitamin D receptor (VDR) mRNA was up-regulated. Both circulating vitamin D and muscle VDR expression increased after vitamin D administration, without exerting appreciable effects on body weight and muscle mass...
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28419350/epidemiology-of-meningitis-and-encephalitis-in-the-united-states-from-2011-2014
#3
Rodrigo Hasbun, Ning Rosenthal, J M Balada-Llasat, Jessica Chung, Steve Duff, Samuel Bozzette, Louise Zimmer, Christine C Ginocchio
Background: Large epidemiological studies evaluating the etiologies, management decisions and outcomes of adults with meningitis and encephalitis in the United States (US) are lacking. Methods: Adult patients (≥18 years) with meningitis or encephalitis by ICD-9 codes available in the Premier Healthcare Database during 2011-2014 were analyzed. Results: A total of 26,429 patients with meningitis or encephalitis were identified. The median age was 43 years; 53% were female...
April 17, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28413360/the-cd31-molecule-a-possible-neuroprotective-agent-in-acute-ischemic-stroke
#4
Tobias Boeckh-Behrens, Justus Kleine, Johannes Kaesmacher, Claus Zimmer, Lucas Schirmer, Sophie Simon, Holger Poppert
BACKGROUND: The transmembrane receptor molecule CD31 is known to have immunomodulatory functions, suggesting a possible neuroprotective effect in the context of acute ischemic stroke by restricting an over-activation of secondary immunological processes. This study examines the density of CD31(+) cells in mechanically extracted thrombi of stroke patients with the aim to test whether the occurrence of CD31(+) cells was associated with a beneficial clinical outcome in those patients. METHODS: Thrombi of 122 consecutive patients with large anterior circulation stroke were collected during intracranial mechanical recanalization...
2017: Thrombosis Journal
https://www.readbyqxmd.com/read/28409567/sf3b1-and-bap1-mutations-in-blue-nevus-like-melanoma
#5
Klaus G Griewank, Hansgeorg Müller, Louise A Jackett, Michael Emberger, Inga Möller, Johannes Ap van de Nes, Lisa Zimmer, Elisabeth Livingstone, Thomas Wiesner, Simone L Scholz, Ioana Cosgarea, Antje Sucker, Tobias Schimming, Uwe Hillen, Bastian Schilling, Annette Paschen, Henning Reis, Thomas Mentzel, Heinz Kutzner, Arno Rütten, Rajmohan Murali, Richard A Scolyer, Dirk Schadendorf
Blue nevi are melanocytic tumors originating in the cutaneous dermis. Malignant tumors may arise in association with or resembling blue nevi, so called 'blue nevus-like melanoma', which can metastasize and result in patient death. Identifying which tumors will behave in a clinically aggressive manner can be challenging. Identifying genetic alterations in such tumors may assist in their diagnosis and prognostication. Blue nevi are known to be genetically related to uveal melanomas (eg, both harboring GNAQ and GNA11 mutations)...
April 14, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28407423/orthopaedic-biofilm-infections
#6
REVIEW
Werner Zimmerli, Parham Sendi
Many infections of the musculoskeletal system are biofilm infections that develop on non-living surfaces. Microorganisms adhere either on dead bone (sequesters) or implants. As a rule for a curative concept, chronic osteomyelitis or implant-associated bone infection must be treated with a combination of surgery and antimicrobial therapy. If an implant is kept in place, or a new device is implanted before complete healing of infection, a biofilm-active antibiotic should be used. Rifamycins are active against biofilms of staphylococci, and fluoroquinolones against those of Gram-negative bacilli...
April 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28403779/design-synthesis-and-biological-evaluation-of-betulinic-acid-derivatives-as-new-antitumor-agents-for-leukemia
#7
Fernanda Waechter, Gloria Santos Silva, Julia Willig, Cristiane Bernardes de Oliveira, Bruna Domingues Vieira, Daniela Barreto Trivella, Aline Rigon Zimmer, Andréia Buffon, Diogo André Pilger, Simone Gnoatto
Chronic myeloid leukemia (CML) is currently treated with imatinib, a Bcr-Abl inhibitor. However, resistance to this drug usually develops over time. Triptolide, a diterpenoid triepoxide, has been shown active against CML cells resistant to imatinib, acting mainly on the level of Bcr-Abl transcription inhibition. Here, we used the triterpene betulinic acid, a known proteasome inhibitor with potential antileukemic activity, as a scaffold for the generation of analogues with predicted triptolide biological activity...
April 12, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28398163/the-effect-of-parenting-practices-on-the-severity-of-gingival-bleeding-in-children
#8
Santhosh Kumar, Jyothi Tadakamadla, Melanie Zimmer-Gembeck, Jeroen Kroon, Ratilal Lalloo, Newell Walter Johnson
BACKGROUND: Studies have consistently reported that parenting practices having an impact on eating styles which determine obesity levels in children. However, there is no study that evaluated the association of parenting practices on gingivitis in children using path analysis to evaluate if oral health-related behaviour mediates this association. This study aimed to test a model of the parenting and family demographic factors that could account for gingivitis in children, with a focus on the mediational roles of oral health-related behaviours and oral hygiene status...
March 10, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28392176/increased-frequency-of-topical-steroids-provides-benefit-in-patients-with-recalcitrant-postsurgical-macular-edema
#9
Peter A Campochiaro, Yong S Han, Tahreem A Mir, Saleema Kherani, Gulnar Hafiz, Claudia Krispel, T Y Alvin Liu, Jiangxia Wang, Adrienne W Scott, Ingrid Zimmer-Galler
PURPOSE: To compare standard and frequent topical steroids for postsurgical macular edema (ME) DESIGN: Randomized clinical trial METHODS: Subjects with postsurgical ME stratified into post-cataract surgery ME (PCSME) and post-other surgery ME (POSME) were randomized to ketorolac four times a day (qid) + 1% prednisolone acetate (PA) every hour while awake (q1hWA, group 1) or qid (group 2). Mean change from baseline best corrected visual acuity (BCVA) was determined at week 12 after which group 2 subjects with persistent edema were crossed over to PA q1hWA...
April 6, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28392135/ten-year-cross-sectional-study-of-mechanically-assisted-crevice-corrosion-in-1352-consecutive-patients-with-metal-on-polyethylene-total-hip-arthroplasty
#10
Daniel K Hussey, Brian J McGrory
BACKGROUND: Mechanically assisted crevice corrosion (MACC) in metal-on-polyethylene total hip arthroplasty (THA) is of concern, but its prevalence, etiology, and natural history are incompletely understood. METHODS: From January 2003 to December 2012, 1352 consecutive THA surgeries using a titanium stem, cobalt-chromium alloy femoral head, and highly cross-linked polyethylene liner from a single manufacturer were performed. Patients were followed at 1-year and 5-year intervals for surveillance, but also seen earlier if they had symptoms...
March 18, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28392068/novel-through-the-scope-technique-for-biliary-plastic-stent-removal-exchange
#11
Vincent Zimmer, Frank Lammert
No abstract text is available yet for this article.
March 1, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28390770/rationale-and-design-of-the-marrowstim-pad-kit-for-the-treatment-of-critical-limb-ischemia-in-subjects-with-severe-peripheral-arterial-disease-mobile-trial-investigating-autologous-bone-marrow-cell-therapy-for-critical-limb%C3%A2-ischemia
#12
S Keisin Wang, Linden A Green, Raghu L Motaganahalli, Michael G Wilson, Andres Fajardo, Michael P Murphy
OBJECTIVE: Critical limb ischemia (CLI) continues to place a significant encumbrance on patients and the health care system as it progresses to limb loss and long-term disability. Traditional methods of revascularization offer a significant benefit; however, for one-third of CLI patients, these surgical options are not technically possible or patency is severely limited by disease burden (deemed "poor-option" for revascularization). In a previous phase I trial, we demonstrated intramuscular injection of concentrated bone marrow aspirate (cBMA) via MarrowStim (Zimmer Biomet, Warsaw, Ind) harvest is safe and may decrease major amputation in patients with CLI unfit for surgical revascularization...
April 5, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28389393/omalizumab-is-effective-in-cold-urticaria-results-of-a-randomized-placebo-controlled-trial
#13
Martin Metz, Andrea Schütz, Karsten Weller, Marina Gorczyza, Sebastian Zimmer, Petra Staubach, Hans F Merk, Marcus Maurer
No abstract text is available yet for this article.
April 4, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28387780/-oligo-aromatic-species-with-one-or-two-conjugated-si-double-bond-length-as-m-dash-si-bonds-near-ir-emission-of-anthracenyl-bridged-tetrasiladiene
#14
Naim M Obeid, Lukas Klemmer, Daniel Maus, Michael Zimmer, Jonathan Jeck, Iulia Bejan, Andrew J P White, Volker Huch, Gregor Jung, David Scheschkewitz
A series of aryl disilenes Tip2Si[double bond, length as m-dash]Si(Tip)Ar (2a-c) and para-arylene bridged tetrasiladienes, Tip2Si[double bond, length as m-dash]Si(Tip)-LU-Si(Tip)[double bond, length as m-dash]SiTip2 (3a-d) are synthesized by the transfer of the Tip2Si[double bond, length as m-dash]SiTip unit to aryl halides and dihalides by nucleophilic disilenides Tip2Si[double bond, length as m-dash]SiTipLi (Tip = 2,4,6-iPr3C6H2, Ar = aryl substituent, LU = para-arylene linking unit). The scope of the nucleophilic Si[double bond, length as m-dash]Si transfer reaction is demonstrated to also include substrates of considerable steric bulk such as mesityl or duryl halides Ar-X (Ar = Mes = 2,4,6-Me3C6H2; Ar = Dur = 2,3,5,6-Me4C6H, X = Br or I)...
April 7, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28387355/transgenerational-transmission-of-a-stress-coping-phenotype-programmed-by-early-life-stress-in-the-japanese-quail
#15
Cédric Zimmer, Maria Larriva, Neeltje J Boogert, Karen A Spencer
An interesting aspect of developmental programming is the existence of transgenerational effects that influence offspring characteristics and performance later in life. These transgenerational effects have been hypothesized to allow individuals to cope better with predictable environmental fluctuations and thus facilitate adaptation to changing environments. Here, we test for the first time how early-life stress drives developmental programming and transgenerational effects of maternal exposure to early-life stress on several phenotypic traits in their offspring in a functionally relevant context using a fully factorial design...
April 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28383070/agrobiodiversity-and-a-sustainable-food-future
#16
Karl S Zimmerer, Stef de Haan
No abstract text is available yet for this article.
April 6, 2017: Nature Plants
https://www.readbyqxmd.com/read/28380455/targeted-next-generation-sequencing-of-mucosal-melanomas-identifies-frequent-nf1-and-ras-mutations
#17
Ioana Cosgarea, Selma Ugurel, Antje Sucker, Elisabeth Livingstone, Lisa Zimmer, Mirjana Ziemer, Jochen Utikal, Peter Mohr, Christiane Pfeiffer, Claudia Pföhler, Uwe Hillen, Susanne Horn, Dirk Schadendorf, Klaus G Griewank, Alexander Roesch
PURPOSE: Mucosal melanoma represents ~1% of all melanomas, frequently having a poor prognosis due to diagnosis at a late stage of disease. Mucosal melanoma differs from cutaneous melanoma not only in terms of poorer clinical outcome but also on the molecular level having e.g. less BRAF and more frequent KIT mutations than cutaneous melanomas. For the majority of mucosal melanomas oncogenic driver mutations remain unknown. EXPERIMENTAL DESIGN AND RESULTS: In our study, 75 tumor tissues from patients diagnosed with mucosal melanoma were analyzed, applying a targeted next generation sequencing panel covering 29 known recurrently mutated genes in melanoma...
March 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28380440/monoglyceride-lipase-deficiency-affects-hepatic-cholesterol-metabolism-and-lipid-dependent-gut-transit-in-apoe-mice
#18
Nemanja Vujic, Melanie Korbelius, Christina Leopold, Madalina Duta-Mare, Silvia Rainer, Stefanie Schlager, Madeleine Goeritzer, Dagmar Kolb, Thomas O Eichmann, Clemens Diwoky, Andreas Zimmer, Robert Zimmermann, Achim Lass, Branislav Radovic, Dagmar Kratky
Monoglyceride lipase (MGL) hydrolyzes monoglycerides (MGs) to glycerol and fatty acids. Among various MG species MGL also degrades 2-arachidonoylglycerol (2-AG), the most abundant endocannabinoid and potent activator of cannabinoid receptors (CBR) 1 and 2. MGL-knockout (-/-) mice exhibit pronounced 2-AG accumulation, but lack central cannabimimetic effects due to CB1R desensitization. We have previously shown that MGL affects plaque stability in apolipoprotein E (ApoE)-/- mice, an established animal model for dyslipidemia and atherosclerosis...
March 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28378104/the-role-of-parental-rearing-practices-and-family-demographics-on-oral-health-related-quality-of-life-in-children
#19
S Kumar, M J Zimmer-Gembeck, J Kroon, R Lalloo, N W Johnson
OBJECTIVES: To evaluate the direct and indirect (via oral health-related behaviour) effects of parental rearing practices on children's Oral Health-Related Quality of Life (OHRQoL) within a family-focused, comprehensive predictive model. METHODS: Participants were 11- to 14-year-old children and their parents living in Telangana State, India (N = 1130). Children were clinically assessed for dental caries, gingivitis, oral hygiene status, fluorosis, and malocclusion, and completed a self-administered questionnaire on oral health-related behaviour and OHRQoL...
April 4, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28376248/keystone-predation-and-molecules-of-keystone-significance
#20
Richard K Zimmer, Graham A Ferrier, Steven J Kim, Rachel R Ogorzalek Loo, Cheryl Ann Zimmer, Joseph A Loo
Keystone species structure ecological communities and are major determinants of biodiversity. A synthesis of research on keystone species is nonetheless missing a critical component -NDASH- the sensory mechanisms for behavioral interactions that determine population- and community-wide attributes. Here, we establish the chemosensory basis for keystone predation by sea stars (Pisaster ochraceus) on mussels. This consumer-resource interaction is prototypic of top-down driven trophic cascades. Each mussel species (Mytilus californianus and M...
April 4, 2017: Ecology
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