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https://www.readbyqxmd.com/read/29145656/refining-operative-strategies-for-optic-nerve-decompression-a-morphometric-analysis-of-transcranial-and-endoscopic-endonasal-techniques-using-clinical-parameters
#1
Steven L Gogela, Lee A Zimmer, Jeffrey T Keller, Norberto Andaluz
BACKGROUND: Various approaches can be considered for decompression of the intracanalicular optic nerve. Although clinical experience has been reported, no quantitative study has yet compared the extent of decompression achieved by an endoscopic endonasal versus transcranial approach. OBJECTIVE: Toward this aim, our morphometric analysis compared both approaches by quantifying the circumferential degree of optic canal decompression that is possible before any meningeal violation, which would result in cerebrospinal fluid (CSF) leak...
May 3, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29143737/validation-of-elisa-methods-for%C3%A2-quantification-of-the-major-birch-allergen-bet-v-1-bsp090
#2
S Kaul, J Zimmer, O Dehus, A Constanzo, A DaasConstanzo, K-H Buchheit, J Asturias, M C Arilla, D Barber, A Bertocchi, B Brunetto, J A Carnes, M Chapman, G Chaudemanche, J Dayan-Kenigsberg, S Döring, F Führer, M T Gallego, P Iacovacci, K M Hanschmann, T Holzhauser, M Hrabina, A Ledesma, P Moingeon, E Nony, C Pini, G Plunkett, M Raulf, G Reese, E Sandberg, I Sander, B Smith, D Strecker, C Valerio, R van Ree, B Weber, S Vieths
To date, the potency of allergen products in Europe is expressed in manufacturer-specific units relative to a product-specific in-house reference. Consequently, cross-product comparability of allergen products from different manufacturers with respect to strength and efficacy is impossible. The Biological Standardisation Programme (BSP) project BSP090 addresses this issue via the establishment of reference standards in conjunction with ELISA methods for the quantification of major allergens in allergen products...
2017: Pharmeuropa Bio & Scientific Notes
https://www.readbyqxmd.com/read/29136625/caries-preventive-effect-of-salt-fluoridation-in-preschool-children-in-the-gambia-a-prospective-controlled-interventional-study
#3
Rainer A Jordan, Andreas Schulte, Alexander C Bockelbrink, Sarah Puetz, Ella Naumova, Lars G Wärn, Stefan Zimmer
The aim of this study was to investigate the anticaries effect of fluoridated salt in a communal feeding program for preschool children. In the Gambian city of Brikama, drinking water had a low fluoride content (0.1 mg F-/L) and young children did not use toothpaste for oral hygiene. Its 2 preschools served as clusters for the trial. Random allocation of the kindergartens was performed by one person not involved in the study, and the clinical examinations were carried out using the envelope method. Meals were prepared with fluoridated salt (250 mg F-/kg salt) in the intervention group but not in the control group...
November 15, 2017: Caries Research
https://www.readbyqxmd.com/read/29135718/case-report-adenocarcinoma-of-the-lacrimal-gland-presenting-as-an-abduction-deficit
#4
Crystal L DeLuca, Regina E Zimmers
SIGNIFICANCE: It is imperative to follow the clinical guidelines for abduction deficits to ensure prompt diagnosis of potentially serious etiologies and monitor only those in which a microvascular etiology is most likely. This case reports highlights a rare diagnosis of a malignant tumor of the lacrimal gland presenting as an abduction deficit. PURPOSE: Tumors of the lacrimal gland can cause abduction deficits, which may mimic an abducens nerve palsy. Abducens nerve palsies are often encountered by optometrists...
November 11, 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/29135335/retrospective-study-of-tapered-1-piece-implants-placed-over-a-10-year-period-in-a-single-private-practice
#5
John Minichetti, Joseph C D'Amore, Anna Yj Hong
Today clinicians have a variety of treatment modalities available to address the increasing number of implant procedures performed each year. Single-stage implant surgery is now commonly used in implant dentistry. With patient demands for immediate restoration, the utilization of 1-piece implants is gaining acceptance. This article reports the results of tapered 1-piece implants (Zimmer Biomet) placed in a single practice over a 10-year period. A total of 33 1-piece dental implants were placed in 24 patients and provisionally restored out of occlusion at the time of surgery...
November 14, 2017: Journal of Oral Implantology
https://www.readbyqxmd.com/read/29134833/introduction
#6
Richard B Zimmer
No abstract text is available yet for this article.
October 2017: Journal of the American Psychoanalytic Association
https://www.readbyqxmd.com/read/29129942/priorities-for-research-in-soil-ecology
#7
Nico Eisenhauer, Pedro M Antunes, Alison E Bennett, Klaus Birkhofer, Andrew Bissett, Matthew A Bowker, Tancredi Caruso, Baodong Chen, David C Coleman, Wietse de Boer, Peter de Ruiter, Thomas H DeLuca, Francesco Frati, Bryan S Griffiths, Miranda M Hart, Stephan Hättenschwiler, Jari Haimi, Michael Heethoff, Nobuhiro Kaneko, Laura C Kelly, Hans Petter Leinaas, Zoë Lindo, Catriona Macdonald, Matthias C Rillig, Liliane Ruess, Stefan Scheu, Olaf Schmidt, Timothy R Seastedt, Nico M van Straalen, Alexei V Tiunov, Martin Zimmer, Jeff R Powell
The ecological interactions that occur in and with soil are of consequence in many ecosystems on the planet. These interactions provide numerous essential ecosystem services, and the sustainable management of soils has attracted increasing scientific and public attention. Although soil ecology emerged as an independent field of research many decades ago, and we have gained important insights into the functioning of soils, there still are fundamental aspects that need to be better understood to ensure that the ecosystem services that soils provide are not lost and that soils can be used in a sustainable way...
July 2017: Pedobiologia
https://www.readbyqxmd.com/read/29129292/targeting-myeloid-cells-in-the-tumor-sustaining-microenvironment
#8
REVIEW
Jonathan Schupp, Franziska K Krebs, Niklas Zimmer, Emily Trzeciak, Detlef Schuppan, Andrea Tuettenberg
Myeloid cells are the most abundant cells in the tumor microenvironment (TME). The tumor recruits and modulates endogenous myeloid cells to tumor-associated macrophages (TAM), dendritic cells (DC), myeloid-derived suppressor cells (MDSC) and neutrophils (TAN), to sustain an immunosuppressive environment. Pathologically overexpressed mediators produced by cancer cells like granulocyte-macrophage colony-stimulating- and vascular endothelial growth factor induce myelopoiesis in the bone marrow. Excess of myeloid cells in the blood, periphery and tumor has been associated with tumor burden...
November 2, 2017: Cellular Immunology
https://www.readbyqxmd.com/read/29128092/quality-requirements-for-allergen-extracts-and-allergoids-for-allergen-immunotherapy
#9
REVIEW
J Zimmer, A Bonertz, S Vieths
All allergen products for allergen immunotherapy currently marketed in the European Union are pharmaceutical preparations derived from allergen-containing source materials like pollens, mites and moulds. Especially this natural origin results in particular demands for the regulatory requirements governing allergen products. Furthermore, the development of regulatory requirements is complicated by the so far missing universal link between certain quality parameters, in particular biological potency, on the one hand and clinical efficacy on the other hand...
November 8, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29122101/the-revival-of-the-doctor-patient-relationship
#10
EDITORIAL
Klaus-Peter Zimmer
No abstract text is available yet for this article.
October 20, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/29121399/alcohol-drinking-and-blood-alcohol-concentration-revisited
#11
Julian E Dilley, Emily Nicholson, Stephen M Fischer, Robin Zimmer, Janice C Froehlich
BACKGROUND: It is widely assumed that the amount of alcohol in the blood reflects the amount of alcohol consumed. However, several factors in addition to amount of alcohol consumed can influence blood alcohol concentration (BAC). The current study examines the effect of alcohol dose, concentration, and volume on BAC in rats with a high alcohol drinking (HAD) phenotype. METHODS: Study one examined the relationship between the amount of alcohol consumed and BAC. Alcohol-naïve, male, HAD rats (N=7) were given access to alcohol for 2 hrs/day for 9 consecutive days with food and water ad libitum...
November 9, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29120945/a-comparison-of-red-cell-rejuvenation-versus-mechanical-washing-for-the-prevention-of-transfusion-associated-organ-injury-in-swine
#12
Marcin J Woźniak, Saqib Qureshi, Nikol Sullo, William Dott, Rebecca Cardigan, Michael Wiltshire, Mintu Nath, Nishith N Patel, Tracy Kumar, Alison H Goodall, Gavin J Murphy
BACKGROUND: We evaluated the effects of two interventions that modify the red cell storage lesion on kidney and lung injury in experimental models of transfusion. METHODS: White-landrace pigs (n = 32) were allocated to receive sham transfusion (crystalloid), 14-day stored allogeneic red cells, 14-day red cells washed using the red cells washing/salvage system (CATS; Fresenius, Germany), or 14-day red cells rejuvenated using the inosine solution (Rejuvesol solution; Zimmer Biomet, USA) and washed using the CATS device...
November 9, 2017: Anesthesiology
https://www.readbyqxmd.com/read/29119301/whole-body-vibration-added-to-treatment-as-usual-is-effective-in-adolescents-with-depression-a-partly-randomized-three-armed-clinical-trial-in-inpatients
#13
Heidrun Lioba Wunram, Stefanie Hamacher, Martin Hellmich, Maxi Volk, Franziska Jänicke, Franziska Reinhard, Wilhelm Bloch, Philipp Zimmer, Christine Graf, Eckhard Schönau, Gerd Lehmkuhl, Stephan Bender, Oliver Fricke
There is growing evidence for the effectiveness of exercise in the treatment of adult major depression. With regard to adolescents, clinical trials are scarce. Due to the inherent symptoms of depression (lack of energy, low motivation to exercise), endurance training forms could be too demanding especially in the first weeks of treatment. We hypothesized that an easy-to-perform passive muscular training on a whole body vibration (WBV) device has equal anti-depressive effects compared to a cardiovascular training, both administered as add-ons to treatment as usual (TAU)...
November 8, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29118575/adherence-to-fingolimod-in-multiple-sclerosis-an-investigator-initiated-prospective-observational-single-center-cohort-study
#14
Andrea Zimmer, Michael Coslovsky, Ivo Abraham, Bernhard F Décard
Objectives: Adherence to multiple sclerosis (MS) treatment is essential to optimize the likelihood of full treatment effect. This prospective, observational, single-center cohort study investigated adherence to fingolimod over the 2 years following treatment initiation. Two facets of adherence - implementation and persistence - were examined and compared between new and experienced users of disease-modifying treatments (DMTs). Materials and methods: Implementation rates were based on the proportion of days covered and calculated as percentages per half-yearly visits and over 2 years, captured through refill data, pill count, and self-report...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29117290/the-dna-methyltransferase-1-dnmt1-controls-the-shape-and-dynamics-of-migrating-poa-derived-interneurons-fated-for-the-murine-cerebral-cortex
#15
Daniel Pensold, Judit Symmank, Anne Hahn, Thomas Lingner, Gabriela Salinas-Riester, Bryan R Downie, Fabian Ludewig, Anne Rotzsch, Natja Haag, Nico Andreas, Katrin Schubert, Christian A Hübner, Tomas Pieler, Geraldine Zimmer
The proliferative niches in the subpallium generate a rich cellular variety fated for diverse telencephalic regions. The embryonic preoptic area (POA) represents one of these domains giving rise to the pool of cortical GABAergic interneurons and glial cells, in addition to striatal and residual POA cells. The migration from sites of origin within the subpallium to the distant targets like the cerebral cortex, accomplished by the adoption and maintenance of a particular migratory morphology, is a critical step during interneuron development...
December 1, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29114028/dynamic-proteomics-of-herpes-simplex-virus-infection
#16
Nir Drayman, Omer Karin, Avi Mayo, Tamar Danon, Lev Shapira, Dor Rafael, Anat Zimmer, Anat Bren, Oren Kobiler, Uri Alon
The cellular response to viral infection is usually studied at the level of cell populations. Currently, it remains an open question whether and to what extent cell-to-cell variability impacts the course of infection. Here we address this by dynamic proteomics-imaging and tracking 400 yellow fluorescent protein (YFP)-tagged host proteins in individual cells infected by herpes simplex virus 1. By quantifying time-lapse fluorescence imaging, we analyze how cell-to-cell variability impacts gene expression from the viral genome...
November 7, 2017: MBio
https://www.readbyqxmd.com/read/29113757/eight-hundred-twenty-five-medial-mobile-bearing-unicompartmental-knee-arthroplaties-the-first-10-year-us%C3%A2-multi-center-survival-analysis
#17
Omar K Alnachoukati, John W Barrington, Keith R Berend, Michael C Kolczun, Roger H Emerson, Adolph V Lombardi, David R Mauerhan
BACKGROUND: FDA approval for the Oxford phase III device was approved for use in the United States in 2004. This study seeks to provide the first long-term, large patient sample size, Oxford phase III multi-site survivorship study in the United States, investigating patient reported outcomes of pain and function, while also providing an in-depth analysis of causes for revision, and finally addressing recent advancements that can help aid the unicompartmental knee arthroplasty (UKA) process and further improve partial knee survivorship...
October 16, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29112102/an-assessment-of-the-academic-impact-of-shock-society-members
#18
Daniel P Milgrom, Leonidas G Koniaris, Nakul P Valsangkar, Neha Lad, Teresa M Bell, Brandon Wojcik, Teresa A Zimmers
Professional society membership enhances career development and productivity by offering opportunities for networking and learning about recent advances in the field. The quality and contribution of such societies can be measured in part through the academic productivity, career status, and funding success rates of their members. Here, using Scopus, NIH RePORTER and departmental websites, we compare characteristics of the Shock Society membership to those of the top 55 NIH-funded American university and hospital-based departments of surgery...
November 3, 2017: Shock
https://www.readbyqxmd.com/read/29112069/neuropsychological-performance-in-african-children-with-hiv-enrolled-in-a-multi-site-anti-retroviral-clinical-trial
#19
Michael J Boivin, Linda Barlow-Mosha, Miriam Chernoff, Barbara Laughton, Bonnie Zimmer, Celeste Joyce, Mutsa Bwakura-Dangarembizi, Mmule Ratswana, Nasreen Abrahams, Lee Fairlie, Hermien Gous, Portia Kamthunzi, Katie McCarthy, Itziar Familiar-Lopez, Patrick Jean-Phillippe, Joan Coetzee, Avy Violari, Mark Cotton, Paul Palumbo
OBJECTIVE & DESIGN: Children with HIV infection (HIV+) are at neuropsychological risk, but few studies have evaluated this at multiple sites in low and middle income countries (LMICs). We compared neuropsychological outcomes at enrollment (>5 yrs age) among HIV+, HIV-uninfected perinatally-exposed (HEU), and HIV unexposed (HU) children from 4 sub-Saharan countries. METHODS: IMPAACT P1060 compared Nevirapine (NVP) versus Lopinavir/Ritonavir (LPVr)-based ART in HIV-infected children 6 to 35 months of age...
November 2, 2017: AIDS
https://www.readbyqxmd.com/read/29107231/influence-of-the-rdl-a301s-mutation-in-the-brown-planthopper-nilaparvata-lugens-on-the-activity-of-phenylpyrazole-insecticides
#20
William T Garrood, Christoph T Zimmer, Oliver Gutbrod, Bettina Lüke, Martin S Williamson, Chris Bass, Ralf Nauen, T G Emyr Davies
We discovered the A301S mutation in the RDL GABA-gated chloride channel of fiprole resistant rice brown planthopper, Nilaparvata lugens populations by DNA sequencing and SNP calling via RNASeq. Ethiprole selection of two field N. lugens populations resulted in strong resistance to both ethiprole and fipronil and resulted in fixation of the A301S mutation, as well as the emergence of another mutation, Q359E in one of the selected strains. To analyse the roles of these mutations in resistance to phenylpyrazoles, three Rdl constructs: wild type, A301S and A301S+Q359E were expressed in Xenopus laevis oocytes and assessed for their sensitivity to ethiprole and fipronil using two-electrode voltage-clamp electrophysiology...
October 2017: Pesticide Biochemistry and Physiology
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