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https://www.readbyqxmd.com/read/27913827/intra-lesional-spatial-correlation-of-static-and-dynamic-fet-pet-parameters-with-mri-based-cerebral-blood-volume-in-patients-with-untreated-glioma
#1
Jens Göttler, Mathias Lukas, Anne Kluge, Stephan Kaczmarz, Jens Gempt, Florian Ringel, Mona Mustafa, Bernhard Meyer, Claus Zimmer, Markus Schwaiger, Stefan Förster, Christine Preibisch, Thomas Pyka
PURPOSE: (18)F-fluorethyltyrosine-(FET)-PET and MRI-based relative cerebral blood volume (rCBV) have both been used to characterize gliomas. Recently, inter-individual correlations between peak static FET-uptake and rCBV have been reported. Herein, we assess the local intra-lesional relation between FET-PET parameters and rCBV. METHODS: Thirty untreated glioma patients (27 high-grade) underwent simultaneous PET/MRI on a 3 T hybrid scanner obtaining structural and dynamic susceptibility contrast sequences...
December 2, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27911020/changes-in-resting-state-connectivity-in-musicians-with-embouchure-dystonia
#2
Bernhard Haslinger, Jonas Noé, Eckart Altenmüller, Valentin Riedl, Claus Zimmer, Tobias Mantel, Christian Dresel
OBJECTIVE: Embouchure dystonia is a highly disabling task-specific dystonia in professional brass musicians leading to spasms of perioral muscles while playing the instrument. As they are asymptomatic at rest, resting-state functional magnetic resonance imaging in these patients can reveal changes in functional connectivity within and between brain networks independent from dystonic symptoms. METHODS: We therefore compared embouchure dystonia patients to healthy musicians with resting-state functional magnetic resonance imaging in combination with independent component analyses...
December 2, 2016: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/27907264/the-legacy-of-large-regime-shifts-in-shallow-lakes
#3
Joy M Ramstack Hobbs, William O Hobbs, Mark B Edlund, Kyle D Zimmer, Kevin M Theissen, Natalie Hoidal, Leah M Domine, Mark A Hanson, Brian R Herwig, James B Cotner
Ecological shifts in shallow lakes from clear-water macrophyte-dominated to turbid-water phytoplankton-dominated are generally thought of as rapid short-term transitions. Diatom remains in sediment records from shallow lakes in the Prairie Pothole Region of North America provide new evidence that the long-term ecological stability of these lakes is defined by the legacy of large regime shifts. We examine the modern and historical stability of 11 shallow lakes. Currently, four of the lakes are in a clear-water state, three are consistently turbid-water, and four have been observed to change state from year to year (transitional)...
December 2016: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/27904720/clinical-results-of-lateral-unicompartmental-knee-arthroplasty-minimum-2-year-follow-up
#4
Kyung Tae Kim, Song Lee, Jeehyoung Kim, Jin Woo Kim, Min Su Kang
BACKGROUND: We investigated the clinical results and early complications after lateral unicompartmental knee arthroplasty (UKA) using the Zimmer unicompartmental high-flex knee (ZUK) prosthesis with a minimum follow-up of 2 years. METHODS: Twenty-seven patients (30 cases) who underwent lateral UKA with the ZUK prosthesis between January 2011 and February 2014 were selected for this study. The mean age of the patients was 63.3 years at the time of surgery, and the mean followup was 3 years and 2 months (range, 24 to 48 months)...
December 2016: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/27903236/erratum-to-adrenal-cortex-expression-quantitative-trait-loci-in-a-german-holstein%C3%A2-%C3%A3-%C3%A2-charolais-cross
#5
Bodo Brand, Markus O Scheinhardt, Juliane Friedrich, Daisy Zimmer, Norbert Reinsch, Siriluck Ponsuksili, Manfred Schwerin, Andreas Ziegler
No abstract text is available yet for this article.
November 30, 2016: BMC Genetics
https://www.readbyqxmd.com/read/27901517/ideomotor-limb-apraxia-as-a-staging-tool-in-individuals-with-alzheimer-s-disease-iliad
#6
William D Soulsby, Nezar El-Ruwie, Shravan Gatla, Katelyn Anderson Zimmer, Safa Najmi, Alexander Chen, John T Chibnall, George T Grossberg
BACKGROUND: Ideomotor apraxia (IMA) is known to affect individuals with Alzheimer's disease (AD). Combined with impaired cognitive function, IMA can support evidence of probable AD. However, apraxia is a condition that is difficult to diagnose. The Postural Knowledge Test (PKT), developed by Mozaz et al, was designed to easily identify limb apraxia in multiple sclerosis yet demonstrated potential utility for AD. ILIAD is a pilot study to investigate correlation between the PKT and Mini-Mental State Examination (MMSE)...
November 2016: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://www.readbyqxmd.com/read/27897337/spectroscopic-structural-and-kinetic-investigation-of-the-ultrafast-spin-crossover-in-an-unusual-cobalt-ii-semiquinonate-radical-complex
#7
Fabian Rupp, Katharina Chevalier, Michèle Graf, Markus Schmitz, Harald Kelm, Anneken Grün, Manuel Zimmer, Markus Gerhards, Christoph van Wüllen, Hans-Jörg Krüger, Rolf Diller
A comprehensive spectroscopic and structural investigation of [CoII(L-N4tBu2)(dbsq)][B(p-C6H4Cl)4] (1, L-N4tBu2 = N,N'-di-tert-butyl-2,11-diaza[3.3](2,6)pyridinophane, dbsq1- = 3,5-di-tert-butylsemiquinonate), the first known octahedral complex with a low-spin (ls) CoII semiquinonate ground state, is reported. Above 200 K, solids as well as solutions of 1 exhibit thermally induced spin-crossover (SCO) from the ls to the high-spin (hs) CoII semiquinonate state instead of the frequently observed valence tautomerism from ls CoIII catecholate to hs CoII semiquinonate...
November 29, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27895348/a-6-year-evaluation-of-223-tapered-dental-implants-and-associated-prosthesis-in-92-patients-at-a-university-hospital
#8
Sana Ehsen Nagi, Farhan Raza Khan, Rabia Ali
The aim of the retrospective study was to assess the clinical and radiographic outcome of the dental implant surgery and prosthetics. It was conducted at the Aga Khan University Hospital, Karachi, and comprised of medical charts and radiographic records of patients visiting between 2010 and 2015. Variables such as implant dimensions, final prosthesis, method of retention, loading protocol and patient factors were analysed. A total of 223 implants (143(64.1%) in maxilla and 80(35.9%) in mandible) were placed in 92 subjects (50(54...
October 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27894866/transcriptional-regulation-of-the-sodium-channel-gene-scn5a-by-gata4-in-human-heart
#9
Anna Tarradas, Mel Lina Pinsach-Abuin, Carlos Mackintosh, Oriol Llorà-Batlle, Alexandra Pérez-Serra, Montserrat Batlle, Félix Pérez-Villa, Thomas Zimmer, Ivan Garcia-Bassets, Ramon Brugada, Pedro Beltran-Alvarez, Sara Pagans
Aberrant expression of the sodium channel gene (SCN5A) has been proposed to disrupt cardiac action potential and cause human cardiac arrhythmias, but the mechanisms of SCN5A gene regulation and dysregulation still remain largely unexplored. To gain insight into the transcriptional regulatory networks of SCN5A, we surveyed the promoter and first intronic regions of the SCN5A gene, predicting the presence of several binding sites for GATA transcription factors (TFs). Consistent with this prediction, chromatin immunoprecipitation (ChIP) and sequential ChIP (Re-ChIP) assays show co-occupancy of cardiac GATA TFs GATA4 and GATA5 on promoter and intron 1 SCN5A regions in fresh-frozen human left ventricle samples...
November 25, 2016: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/27894148/catastrophic-failure-of-regenerex-tibial-components-a-case-series
#10
Gavin Stormont, Daniel Stormont
The aim of this study was to analyze short-term metal failures in well-placed Signature-guided Regenerex (Zimmer Biomet, Warsaw, IN) tibial components in a limited patient series. A retrospective, consecutive, nonrandomized, unblinded study from a limited cohort of young active osteoarthritis patients was conducted. All cases received a Regenerex tibial component which we evaluated for metal failure. Patients met the then current indications from the Center for Medicare and Medicaid Services Guidelines for knee replacement...
November 28, 2016: Journal of Knee Surgery
https://www.readbyqxmd.com/read/27890891/mid-term-clinical-results-of-versys-hip-system-zimmer-uncemented-total-hip-replacement-arthroplasty
#11
Hidemi Kawaji, Takuya Uematsu, Naoya Hoshikawa, Hiroshi Watanabe, Shinro Takai
: Recent reports suggest that uncemented total hip replacement arthroplasty (THR) results in favorable short- to mid-term clinical results. In the present study, we assessed the mid-term clinical results of VerSys Hip System uncemented THR at our hospital. MATERIALS AND METHODS: We studied patients who received THR using VerSys Hip System and who could be followed-up more than 3 years. Clinical records were used to retrospectively identify patient characteristics, which included age, gender, disease requiring THR, preoperative and postoperative pain score of the Japan Orthopaedic Association scoring system, range of motion in flexion and abduction, operating time, intraoperative complication, and additional operation or revision surgery...
2016: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/27889581/handling-of-hazardous-drugs-effect-of-an-innovative-teaching-session-for-nursing-students
#12
Janine Zimmer, Stefanie Hartl, Katrin Standfuß, Till Möhn, Astrid Bertsche, Roberto Frontini, Martina P Neininger, Thilo Bertsche
BACKGROUND: Imparting knowledge and practical skills in hazardous drug handling in nursing students' education is essential to prevent hazardous exposure and to preserve nurses' health. OBJECTIVES: This study aimed at comparing routine nursing education with an additional innovative teaching session. DESIGN: A prospective controlled study in nursing students was conducted in two study periods: (i) a status-quo period (routine education on handling hazardous drugs) followed by (ii) an intervention period (additional innovative teaching session on handling hazardous drugs)...
November 13, 2016: Nurse Education Today
https://www.readbyqxmd.com/read/27883997/cbt4bn-a-randomized-controlled-trial-of-online-chat-and-face-to-face-group-therapy-for-bulimia-nervosa
#13
Stephanie C Zerwas, Hunna J Watson, Sara M Hofmeier, Michele D Levine, Robert M Hamer, Ross D Crosby, Cristin D Runfola, Christine M Peat, Jennifer R Shapiro, Benjamin Zimmer, Markus Moessner, Hans Kordy, Marsha D Marcus, Cynthia M Bulik
OBJECTIVE: Although cognitive-behavioral therapy (CBT) represents the first-line evidence-based psychotherapy for bulimia nervosa (BN), most individuals seeking treatment do not have access to this specialized intervention. We compared an Internet-based manualized version of CBT group therapy for BN conducted via a therapeutic chat group (CBT4BN) to the same treatment conducted via a traditional face-to-face group therapy (CBTF2F). METHOD: In a two-site, randomized, controlled noninferiority trial, we tested the hypothesis that CBT4BN would not be inferior to CBTF2F...
November 25, 2016: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/27872905/interferon-driven-deletion-of-antiviral-b-cells-at-the-onset-of-chronic-infection
#14
Benedict Fallet, Kerstin Narr, Yusuf I Ertuna, Melissa Remy, Rami Sommerstein, Karen Cornille, Mario Kreutzfeldt, Nicolas Page, Gert Zimmer, Florian Geier, Tobias Straub, Hanspeter Pircher, Kevin Larimore, Philip D Greenberg, Doron Merkler, Daniel D Pinschewer
Inadequate antibody responses and perturbed B cell compartments represent hallmarks of persistent microbial infections, but the mechanisms whereby persisting pathogens suppress humoral immunity remain poorly defined. Using adoptive transfer experiments in the context of a chronic lymphocytic choriomeningitis virus (LCMV) infection of mice, we have documented rapid depletion of virus-specific B cells that coincided with the early type I interferon response to infection. We found that the loss of activated B cells was driven by type I interferon (IFN-I) signaling to several cell types including dendritic cells, T cells and myeloid cells...
October 21, 2016: Science Immunology
https://www.readbyqxmd.com/read/27869336/use-of-the-synergist-piperonyl-butoxide-can-slow-the-development-of-alpha-cypermethrin-resistance-in-the-whitefly-bemisia-tabaci
#15
C T Zimmer, M Panini, K S Singh, E L Randall, L M Field, E Roditakis, E Mazzoni, C Bass
The development of insecticide resistance in insect pests of crops is a growing threat to sustainable food production, and strategies that slow the development of resistance are therefore urgently required. The insecticide synergist piperonyl butoxide (PBO) inhibits certain insect detoxification systems and so may delay the evolution of metabolic resistance. In the current study we characterized resistance development in the silverleaf whitefly, Bemisia tabaci, after selection with either a neonicotinoid (thiacloprid) or pyrethroid (alpha-cypermethrin) insecticide alone or in combination with PBO...
November 21, 2016: Insect Molecular Biology
https://www.readbyqxmd.com/read/27869329/novel-compound-heterozygous-synaptojanin-1-mutation-causes-l-dopa-responsive-dystonia-parkinsonism-syndrome
#16
Marc-Alexander Rauschendorf, Meike Jost, Friedrich Stock, Andreas Zimmer, Bernd Rösler, Michel Rijntjes, Tobias Piroth, Volker Arnd Coenen, Peter Christoph Reinacher, Philipp T Meyer, Lars Frings, Cornelius Weiller, Judith Fischer, Stephan Klebe
No abstract text is available yet for this article.
November 21, 2016: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/27864579/automated-segmentation-reveals-silent-radiographic-progression-in-adult-onset-vanishing-white-matter-disease
#17
Thomas Huber, Marina Herwerth, Esther Alberts, Jan S Kirschke, Claus Zimmer, Ruediger Ilg
Adult-onset vanishing white-matter disease (VWM) is a rare autosomal recessive disease with neurological symptoms such as ataxia and paraparesis, showing extensive white-matter hyperintensities (WMH) on magnetic resonance (MR) imaging. Besides symptom-specific scores like the International Cooperative Ataxia Rating Scale (ICARS), there is no established tool to monitor disease progression. Because of extensive WMH, visual comparison of MR images is challenging. Here, we report the results of an automated method of segmentation to detect alterations in T2-weighted fluid-attenuated-inversion-recovery (FLAIR) sequences in a one-year follow-up study of a clinically stable patient with genetically diagnosed VWM...
November 18, 2016: Neuroradiology Journal
https://www.readbyqxmd.com/read/27863254/acute-exposure-to-high-environmental-ammonia-hea-triggers-the-emersion-response-in-the-green-shore-crab
#18
Alex M Zimmer, Chris M Wood
The physiological effects of high environmental ammonia (HEA) exposure have been well documented in many aquatic species. In particular, it has recently been demonstrated that exposure to ammonia in fish leads to a similar hyperventilatory response as observed during exposure to hypoxia. In littoral crabs, such as the green crab (Carcinus maenas), exposure to severe hypoxia triggers an emersion response whereby crabs escape hypoxia to breathe air. We hypothesized that exposure to HEA in green crabs would lead to a similar behavioural response which is specific to ammonia...
November 15, 2016: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/27862108/predictors-of-dropout-in-face-to-face-and-internet-based-cognitive-behavioral-therapy-for-bulimia-nervosa-in-a-randomized-controlled-trial
#19
Hunna J Watson, Michele D Levine, Stephanie C Zerwas, Robert M Hamer, Ross D Crosby, Caroline S Sprecher, Amy O'Brien, Benjamin Zimmer, Sara M Hofmeier, Hans Kordy, Markus Moessner, Christine M Peat, Cristin D Runfola, Marsha D Marcus, Cynthia M Bulik
OBJECTIVE: We sought to identify predictors and moderators of failure to engage (i.e., pretreatment attrition) and dropout in both Internet-based and traditional face-to-face cognitive-behavioral therapy (CBT) for bulimia nervosa. We also sought to determine if Internet-based treatment reduced failure to engage and dropout. METHOD: Participants (N = 191, 98% female) were randomized to Internet-based CBT (CBT4BN) or traditional face-to-face group CBT (CBTF2F). Sociodemographics, clinical history, eating disorder severity, comorbid psychopathology, health status and quality of life, personality and temperament, and treatment-related factors were investigated as predictors...
November 12, 2016: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/27861159/pharmacological-agonists-for-more-targeted-cns-radio-pharmaceuticals
#20
EDITORIAL
Luc Zimmer
No abstract text is available yet for this article.
November 16, 2016: Oncotarget
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