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Bernd Zimmer, Hiba Sino
PURPOSE: The objective of this investigation was to develop equations to describe the geometric relations among "targeted incisor inclinations" (tU1, tL1) accommodating different cephalometric norms (Ricketts, Bergen, etc.) with the "expected inclinations" (eU1, eL1), as they can be generated by bracket torque values according to Andrews, Roth, Ricketts, and MBT. METHODS: In its key parts, the present study is a theoretical work in which structural relationships are described using standard mathematical and geometric methodologies...
March 15, 2018: Journal of Orofacial Orthopedics, Fortschritte der Kieferorthopädie
Kamila Cagliari Zenki, Eduardo Kalinine, Eduardo R Zimmer, Thainá Garbino Dos Santos, Ben Hur Marins Mussulini, Luis Valmor Cruz Portela, Diogo Lösch de Oliveira
Several works have demonstrated that status epilepticus (SE) induced-neurodegeneration appears to involve an overactivation of N-methyl-D-aspartate receptors and treatment with high-affinity NMDAR antagonists is neuroprotective against this brain damage. However, these compounds display undesirable side effects for patients since they block physiological NMDA receptor dependent-activity. In this context, memantine (MN), a well tolerable low-affinity NMDAR channel blocker, will be a promising alternative, since it does not compromise the physiological role of NMDA receptors on synaptic transmission...
March 12, 2018: Neurotoxicology
L Zimmer, P Fourneret
Methylphenidate (MPH) remains the only accessible psychostimulant used in France in the attention and behavior disturbances of attention deficit disorder with or without hyperactivity (ADHD). Its prescription has been extended during the past decade to other neurodevelopmental disorders in children and adolescents, also associated with a deficit of attentional resources or, more broadly, fragility of executive functions. Despite its efficiency, validated by more than 400 randomized controlled and double-blind studies, and the good tolerance of MPH in these indications, this treatment remains limited in France because of many fears and other prejudices on the part of medical practitioners and/or families...
March 12, 2018: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
Juliane Kupsch, Thomas Jackisch, Klaus E Matzel, Joerg Zimmer, Andreas Schreiber, Anja Sims, Helmut Witzigmann, Sigmar Stelzner
PURPOSE: Severity of anorectal dysfunction after low anterior resection is associated with various patient- and treatment-related factors. We aimed to quantify anorectal dysfunction after treatment for rectal cancer using the low anterior resection syndrome (LARS) score. METHODS: We retrieved from a prospective database 331 eligible patients on whom anterior resection for rectal cancer had been performed from 2000 to 2014. All patients were sent a LARS score accompanied by a supplementary questionnaire...
March 15, 2018: International Journal of Colorectal Disease
Stefanie Bette, Melanie Barz, Thomas Huber, Christoph Straube, Friederike Schmidt-Graf, Stephanie E Combs, Claire Delbridge, Julia Gerhardt, Claus Zimmer, Bernhard Meyer, Jan S Kirschke, Tobias Boeckh-Behrens, Benedikt Wiestler, Jens Gempt
Recent studies suggested that postoperative hypoxia might trigger invasive tumor growth, resulting in diffuse/multifocal recurrence patterns. Aim of this study was to analyze distinct recurrence patterns and their association to postoperative infarct volume and outcome. 526 consecutive glioblastoma patients were analyzed, of which 129 met our inclusion criteria: initial tumor diagnosis, surgery, postoperative diffusion-weighted imaging and tumor recurrence during follow-up. Distinct patterns of contrast-enhancement at initial diagnosis and at first tumor recurrence (multifocal growth/progression, contact to dura/ventricle, ependymal spread, local/distant recurrence) were recorded by two blinded neuroradiologists...
March 14, 2018: Scientific Reports
A Beltz, D Gösswein, S Zimmer, R H Stauber, J Hagemann, S Strieth, C Matthias, J Künzel
BACKGROUND: The TNM (tumor, nodes, metastasis) classification is updated periodically according to the literature and international recommendations. With the 8th edition, notable changes have been developed especially with regard to oropharyngeal cancer. MATERIALS AND METHODS: The modifications as well as the practicability of the classification for staging of oropharyngeal cancers are demonstrated on the basis of cases from the tumor database. RESULTS: The latest edition of the TNM classification realizes requirements to differentiate between human papilloma virus (HPV) positive and HPV-negative tumors during staging...
March 13, 2018: HNO
Matthias Christian Reichert, Juozas Kupcinskas, Marcin Krawczyk, Christoph Jüngst, Markus Casper, Frank Grünhage, Beate Appenrodt, Vincent Zimmer, Susanne Nicole Weber, Algimantas Tamelis, Jaune Ieva Lukosiene, Neringa Pauziene, Gediminas Kiudelis, Laimas Jonaitis, Christoph Schramm, Tobias Goeser, Antje Schulz, Maciej Malinowski, Matthias Glanemann, Limas Kupcinskas, Frank Lammert
BACKGROUND: Colonic diverticulosis is one of the most common gastroenterological disorders. Although diverticulosis is typically benign, many individuals develop diverticulitis or other aspects of diverticular disease. Diverticulosis is thought to stem from a complex interaction of environmental, dietary, and genetic factors; however, the contributing genetic factors remain unknown. OBJECTIVE: The aim of our present study was to determine the role of genetic variants within genes encoding for collagens of the connective tissue in diverticulosis...
March 12, 2018: Diseases of the Colon and Rectum
Rüdiger M Zimmerer, Nils-Claudius Gellrich, Sophie von Bülow, Edward Bradley Strong, Edward Ellis, Maximilian E H Wagner, Gregorio Sanchez Aniceto, Alexander Schramm, Michael P Grant, Lim Thiam Chye, Alvaro Rivero Calle, Frank Wilde, Daniel Perez, Gido Bittermann, Nicholas R Mahoney, Marta Redondo Alamillos, Joanna Bašić, Marc Metzger, Michael Rasse, Jan Dittman, Elke Rometsch, Kathrin Espinoza, Ronny Hesse, Carl-Peter Cornelius
PURPOSE: Reconstruction of orbital wall fractures is demanding and has improved dramatically with the implementation of new technologies. True-to-original accuracy of reconstruction has been deemed essential for good clinical outcome, and reasons for unfavorable clinical outcome have been researched extensively. However, no detailed analysis on the influence of plate position and surface contour on clinical outcome has yet been published. MATERIALS AND METHODS: Data from a previous study were used for an ad-hoc analysis to identify predictors for unfavorable outcome, defined as diplopia or differences in globe height and/or globe projection of >2 mm...
February 1, 2018: Journal of Cranio-maxillo-facial Surgery
Adolph V Lombardi, Antonio G Manocchio, Keith R Berend, Michael J Morris, Joanne B Adams
INTRODUCTION: Short stem femoral components in primary total hip arthroplasty (THA) have increased in popularity since the advent of minimally invasive surgical techniques. The concept of a short stem is particularly compatible with tapered designs where the goal is to offload forces proximally in the femur. The purpose of this retrospective review was to review our early experience with a short, tapered titanium femoral component with updated design features. MATERIALS AND METHODS: Beginning in November 2011 through February 2012, 92 consented patients (93 hips), at a single center, were treated with primary cementless THA using a short stem, tapered femoral component (Taperloc® Complete Microplasty; Zimmer Biomet, Warsaw, Indiana) and were available for review with a minimum two-year follow-up...
March 12, 2018: Surgical Technology International
Karim Sabeh, Milad Alam, Samuel Rosas, Shahrose Hussain, Michaela Schneiderbauer
INTRODUCTION: The growing trends of total knee arthroplasty (TKA) foreshadow an inevitable increase in the financial burden on healthcare expenditure estimated to almost nine billion dollars annually. This study aims to demonstrate the potential savings when using all-polyethylene (AP) compared to metal-backed (MB) tibial components and describes the cost variability amongst three major commercially available implants. MATERIALS AND METHODS: The cost of AP versus MB implants was analyzed using a large nationwide database, Emergency Care Research Institute (ECRI)...
March 12, 2018: Surgical Technology International
Florian Erhard, Anne Halenius, Cosima Zimmermann, Anne L'Hernault, Daniel J Kowalewski, Michael P Weekes, Stefan Stevanovic, Ralf Zimmer, Lars Dölken
Ribosome profiling has been used to predict thousands of short open reading frames (sORFs) in eukaryotic cells, but it suffers from substantial levels of noise. PRICE ( is a computational method that models experimental noise to enable researchers to accurately resolve overlapping sORFs and noncanonical translation initiation. We experimentally validated translation using major histocompatibility complex class I (MHC I) peptidomics and observed that sORF-derived peptides efficiently enter the MHC I presentation pathway and thus constitute a substantial fraction of the antigen repertoire...
March 12, 2018: Nature Methods
Y L Rodrigues, M T Mathew, L G Mercuri, J S P da Silva, B Henriques, J C M Souza
The aim of this study was to perform a literature review on the use of finite element modeling (FEM) for the evaluation of the biomechanical behavior of temporomandibular joint replacement (TMJR) devices. An electronic search of online medical and scientific literature database was conducted using selected search terms. The search identified 307 studies, of which 19 were considered relevant to this study. Of the 19 selected studies, 10 (52.6%) investigated the influence of geometry and fixation methods, while two (10...
March 8, 2018: International Journal of Oral and Maxillofacial Surgery
Tomislav A Zrnc, Jürgen Wallner, Wolfgang Zemann, Mauro Pau, Christian Gstettner, Luka Brcic, Alexandre T Assaf, Hamid Hassanzadeh, Matthias Feichtinger, Katja Schwenzer-Zimmerer
OBJECTIVES: Determination of tumor margins in patients with squamous cell carcinoma of the head and neck (SCCHN) is mostly based on preoperative magnetic resonance imaging (MRI) or computed tomography scans (CT). Local recurrence of disease is often correlated with the presence of positive resection margins after surgical treatment. Positron emission tomography/computed tomography (PET/CT) imaging plays a crucial role in the assessment of patients with SCCHN. The purpose of this study was to determine whether PET/CT could predict tumor extension...
February 19, 2018: Journal of Cranio-maxillo-facial Surgery
H Sino, B Zimmer, I Schelper, S Schenk-Kazan, F Streibelt
PURPOSE: To determine the reproducibility and statistical measures of the torque coordination angle (TCA). METHODS: A total of 107 final cephalograms and corresponding casts were included, all reflecting treatment outcomes that met high qualitative standards, one of them being a Peer Assessment Rating (PAR) score of ≤3. Based on these records, the TCA was measured as a parameter to identify differences related to tooth morphology and bracket position between the torque-relevant reference plane at the bracket base and the long axis of a tooth...
March 9, 2018: Journal of Orofacial Orthopedics, Fortschritte der Kieferorthopädie
Jakub Śliwa, Anna Rosner-Tenerowicz, Anna Kryza-Ottou, Sylvester Ottou, Artur Wiatrowski, Michał Pomorski, Lesław Sozański, Mariusz Zimmer
BACKGROUND: Pelvic organ prolapse is the most frequent medical condition in women in the postmenopausal age. The pathophysiology is multifactorial. OBJECTIVES: The purpose of this paper was to analyze the prevalence of selected anamnestic factors in the population of women treated due to pelvic organ prolapse in the 2nd Department and Clinic of Obstetrics and Gynecology Wroclaw Medical University (Poland). MATERIAL AND METHODS: A total of 104 medical histories of women treated in the 2nd Department and Clinic of Obstetrics and Gynecology in the years 2012-2013 due to pelvic organ prolapse were analyzed...
February 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Dick Zimmer
No abstract text is available yet for this article.
April 2018: American Journal of Public Health
Amanda E Coleman, Scott A Brown, Marcus Stark, Lawrence Bryson, Alicia Zimmerman, Tanja Zimmering, Anne M Traas
Objectives The aim of this study was to compare the effects of multiple once- or twice-daily oral dosage rates of the angiotensin II, type-1 receptor blocker, telmisartan (TEL), or placebo (PLA) on indirect systolic arterial blood pressure (SBP) in awake, clinically normal cats. Methods Utilizing an incomplete crossover design and following a 14 day acclimation period, 28 healthy laboratory cats were randomized to undergo treatment with three of the following 14 day treatment protocols, each separated by a 1 week washout period: oral PLA q24h, oral TEL at a dosage of 1, 1...
March 1, 2018: Journal of Feline Medicine and Surgery
Vishnupriya Gourineni, Maria L Stewart, Didem Icoz, J Paul Zimmer
Ingredients delivering functional and nutritional benefits are of interest to food manufacturers. Isomaltooligosaccharides (IMOs) which serve as alternate sweeteners fit into this category. IMOs are a mixture of α-(1 → 6) and α-(1 → 4)-linked glucose oligomers, synthesized by an enzymatic reaction from starch (corn, tapioca). The aim of this study was to evaluate the fermentability and glycemic response of IMO in a healthy population. Two randomized, double-blind, placebo-controlled, cross-over human studies were conducted...
March 3, 2018: Nutrients
V Zimmer
No abstract text is available yet for this article.
March 3, 2018: Clinical Gastroenterology and Hepatology
Karen Steindorf, Martina E Schmidt, Philipp Zimmer
A growing number of literature reports positive effects of physical activity and exercise. These effects concern prevention, mortality and progress of cancer. Furthermore they show a reduction of disease- and treatment-specific side effects, which implies a better patients' quality of life. Evidence shows a decreased mortality risk in patients with physically active cancer of colon, breast, ovaries and prostate. Activity recommendations for patients with cancer do not differ from those for healthy persons...
March 2018: Deutsche Medizinische Wochenschrift
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