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Apne of prematurity

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https://www.readbyqxmd.com/read/25833984/dietary-%C3%AF-3-polyunsaturated-fatty-acids-decrease-retinal-neovascularization-by-adipose-endoplasmic-reticulum-stress-reduction-to-increase-adiponectin
#1
Zhongjie Fu, Chatarina A Lofqvist, Zhuo Shao, Ye Sun, Jean-Sebastien Joyal, Christian G Hurst, Ricky Z Cui, Lucy P Evans, Katherine Tian, John Paul SanGiovanni, Jing Chen, David Ley, Ingrid Hansen Pupp, Ann Hellstrom, Lois E H Smith
BACKGROUND: Retinopathy of prematurity (ROP) is a vision-threatening disease in premature infants. Serum adiponectin (APN) concentrations positively correlate with postnatal growth and gestational age, important risk factors for ROP development. Dietary ω-3 (n-3) long-chain polyunsaturated fatty acids (ω-3 LCPUFAs) suppress ROP and oxygen-induced retinopathy (OIR) in a mouse model of human ROP, but the mechanism is not fully understood. OBJECTIVE: We examined the role of APN in ROP development and whether circulating APN concentrations are increased by dietary ω-3 LCPUFAs to mediate the protective effect in ROP...
April 2015: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/24427493/early-aggressive-parenteral-nutrition-induced-high-insulin-like-growth-factor-1-igf-1-and-insulin-like-growth-factor-binding-protein-3-igfbp3-levels-can-prevent-risk-of-retinopathy-of-prematurity
#2
Emrah Can, Ali Bülbül, Sinan Uslu, Fatih Bolat, Serdar Cömert, Asiye Nuhoğlu
OBJECTIVE: To evaluate early aggressive vs. conservative nutrition and its effect on Retinopathy of Prematurity (ROP) in <32 weeks of gestation neonates. METHODS: A prospective, randomized, clinical study was conducted in NICU with a total of 75 preterm infants. In the intervention group, infants received early aggressive nutrition immediately after birth, in the control group infants were started on conventional parenteral nutrition (PN). Blood samples were obtained for Insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 3 (IGFBP3) levels before commencement of PN on the first postnatal day, and from week 1 to 6 every week...
August 2013: Iranian Journal of Pediatrics
https://www.readbyqxmd.com/read/23931276/circulating-aminopeptidase-activities-in-men-and-women-with-essential-hypertension
#3
R Sánchez-Agesta Ortega, J M Arias de Saavedra-Alías, A Liébana-Cañada, B Sánchez-Muñoz, J M Martínez-Martos, M J Ramírez-Expósito
Essential hypertension is one of the major contributors to premature morbidity and mortality due to the incresased risk for coronary heart disease, stroke, renal disease, peripheral vascular disease and vascular dementia for both men and women. However, its basic causes remain unknown. In the present work we studied the activity of several proteolytic regulatory enzymes related to renin-angiotensin-system (RAS) (aminopeptidase A, APA; aminopeptidase N, APN; aminopeptidase B, APB; and insulin-regulated aminopeptidase, IRAP); with oxytocin regulation (oxytocinase); with the metabolism of GnRH and TRH (pyrrolidone carboxypeptidase, Pcp); and with enkephalins metabolism (enkephalindegrading activity, EDA), to elucidate their role in the mechanisms responsible of essential hypertension and to discuss the possible gender differences...
2013: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/22333254/-correlation-of-adiponectin-gene-snp-45t-g-polymorphism-and-premature-coronary-heart-disease-of-han-ethnic-males
#4
Nan-nan Zhou, Jing-ming Zhuo, Jian-chun Wang, Xiao-dong Li, Lin Ye
OBJECTIVE: To examine the relationship between single nucleotide polymorphism (SNP) of adiponectin (APN) locus +45T/G and Han male patients with premature coronary artery heart disease (pCAD). METHODS: A total of 423 male patients of Han ethnic group (< 55 yr old) undergoing coronary arteriography were recruited. Among them, 358 patients were diagnosed as pCAD while another 65 normal control (NC). All subjects were genotyped for adiponectin gene SNP +45 by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay...
December 27, 2011: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/19342600/adiponectin-suppresses-pathological-microvessel-formation-in-retina-through-modulation-of-tumor-necrosis-factor-alpha-expression
#5
Akiko Higuchi, Koji Ohashi, Shinji Kihara, Kenneth Walsh, Noriyuki Ouchi
The fat-derived hormone adiponectin has been shown to have a protective role in macrovascular disorders. However, nothing is known about the function of adiponectin in retinal microvessel disease. Here, we investigated the causal role of adiponectin in retinal vessel formation and inflammation under conditions of hypoxia. When neonatal mice were subjected to ischemia-induced retinopathy, pathological retinal neovascularization during ischemia was exacerbated in adiponectin-knockout (APN-KO) mice compared with wild-type mice (neovascular area: 17...
May 8, 2009: Circulation Research
https://www.readbyqxmd.com/read/12357042/glucagon-like-peptide-2-enhances-maltase-glucoamylase-and-sucrase-isomaltase-gene-expression-and-activity-in-parenterally-fed-premature-neonatal-piglets
#6
Yvette M Petersen, Jan Elnif, Mette Schmidt, Per T Sangild
Exogenous glucagon-like peptide 2 (GLP-2) mimics the stimulatory effect of enteral nutrition on intestinal mucosal growth in preterm neonatal pigs. Little is known about its effects on small intestinal function. In this study, we investigated whether the trophic actions of GLP-2 and enteral nutrition are paralleled by effects on small intestinal function. Cesarean-delivered piglets (92% of gestation) were given either a parenteral nutrient infusion [total parenteral nutrition (TPN), n = 7], TPN + human GLP-2 (25 nmol/kg/d, n = 8), or enteral nutrition (ENT, n = 6) for 6 d...
October 2002: Pediatric Research
https://www.readbyqxmd.com/read/7815318/neonatal-case-management-a-challenge-for-advanced-practice-nurses
#7
P L Bell
With a presidential commitment to health care reform, advanced practice nurses (APNs) are challenged to rethink critical care for the growing number of premature infants born each year. Threats of shortened lengths of stay force APNs to case manage the long-term needs of compromised neonates in their homes and communities. Recent studies have shown that earlier discharge from neonatal intensive care units with proper home follow-up is not only cost saving, but is also safe and beneficial to the infant and family...
September 1994: Journal of Perinatal & Neonatal Nursing
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