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Haematology clinic

Ori Wand, Oshrat E Tayer-Shifman, Shafik Khoury, Alon Y Hershko
INTRODUCTION: There are insufficient data on the aetiologic factors underlying splenic infarction (SI). Therefore, there is no consensus regarding the appropriate diagnostic approach. METHODS: We conducted a retrospective analysis of all patients admitted with SI from 1/2004 to 12/2014. Medical records were screened for the clinical presentation, underlying causes, associated medical conditions and methods of patient evaluation. RESULTS: We found 89 subjects with 90 episodes of SI...
June 21, 2018: Annals of Medicine
María Martínez, Jesica Montero, Adriana Pineda, Víctor Mijares, María Lares, Emily Catalano, Elizabeth Ferrer
Background: Toxocariasis is a widespread zoonosis caused by canine and feline Toxocara spp. In Venezuela, seroepidemiological studies in Aragua State have been carried out only in preschool children. The objective of this study was to determine the prevalence of anti-Toxocara spp. antibodies and identify clinical symptoms and risk factors of Toxocara spp. infection in school children in two municipalities of Aragua State of Venezuela. Methods: A cross-sectional field study with 259 children between 6 and 12 y of age was conducted in six schools in Aragua State...
June 16, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
L M Lobigs, P Peeling, B Dawson, Y O Schumacher
It is well described that numerous environmental factors, including exercise, modulate plasma volume (PV). These modulations prove problematic when a number of haematological markers are measured as a concentration in blood plasma. A primary example is haemoglobin concentration ([Hb]), a marker of erythropoiesis commonly used within medicine and also used to detect blood doping. Natural changes in PV can confound [Hb] values when a volume change is detected rather than a true change in haemoglobin mass (Hbmass ) (e...
June 17, 2018: European Journal of Sport Science
Gita Thanarajasingam, Lori M Minasian, Frederic Baron, Franco Cavalli, R Angelo De Claro, Amylou C Dueck, Tarec C El-Galaly, Neil Everest, Jan Geissler, Christian Gisselbrecht, John Gribben, Mary Horowitz, S Percy Ivy, Caron A Jacobson, Armand Keating, Paul G Kluetz, Aviva Krauss, Yok Lam Kwong, Richard F Little, Francois-Xavier Mahon, Matthew J Matasar, María-Victoria Mateos, Kristen McCullough, Robert S Miller, Mohamad Mohty, Philippe Moreau, Lindsay M Morton, Sumimasa Nagai, Simon Rule, Jeff Sloan, Pieter Sonneveld, Carrie A Thompson, Kyriaki Tzogani, Flora E van Leeuwen, Galina Velikova, Diego Villa, John R Wingard, Sophie Wintrich, John F Seymour, Thomas M Habermann
Tremendous progress in treatment and outcomes has been achieved across the whole range of haematological malignancies in the past two decades. Although cure rates for aggressive malignancies have increased, nowhere has progress been more impactful than in the management of typically incurable forms of haematological cancer. Population-based data have shown that 5-year survival for patients with chronic myelogenous and chronic lymphocytic leukaemia, indolent B-cell lymphomas, and multiple myeloma has improved markedly...
June 12, 2018: Lancet Haematology
J Krygier, G Leemans, R Forsyth, A de Becker, J Gutermuth, M Grosber
BACKGROUND: Pityriasis rubra pilaris (PRP) is a cutaneous syndrome of unknown origin. Most cases are sporadic and acquired. Herein we report a fifth case of PRP-like eruption associated with ponatinib, a tyrosine kinase inhibitor (TKI). PATIENTS AND METHODS: A 60-year-old woman presented at the dermatology department with an erythemato-squamous eruption present for 2weeks. The patient was also being treated in haematology for recurrence of acute lymphoblastic leukaemia...
June 11, 2018: Annales de Dermatologie et de Vénéréologie
Mónika Ecsedy, Béla Csákány, Illés Kovács, Miklós Resch, Zoltán Nagy, Zsuzsa Récsán
We present cases of blinding spontaneous suprachoroidal haemorrhage in anticoagulant taking wet-AMD patients. A retrospective study has been performed to present the clinical course, management and final outcome of spontaneous suprachoroidal haemorrhage in 7 eyes of six age-related macular degeneration patients seen in our clinic from January 2016 to April 2017. All patients were on chronic oral anticoagulant therapy because of cardiovascular disorder. In one patient, haematological disorder was also present modifying significantly the haemostasis...
June 2018: Orvosi Hetilap
L Das, A Bhansali, R Walia
BACKGROUND: Sodium-glucose co-transporter-2 inhibitors are novel antidiabetes drugs that act via inhibition of renal glucose reabsorption. This action causes osmotic diuresis, reduces intravascular volume and is associated with various adverse effects. In the present paper, we describe the first report on the unmasking of underlying polycythemia vera by canagliflozin in a person with Type 2 diabetes mellitus, which was temporally related to the use of the drug. CASE REPORT: A 51-year-old obese man with Type 2 diabetes was prescribed canagliflozin 100 mg for control of his glycaemia...
June 11, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
Alejandro Callejas-Díaz, Cristina Fernández-Pérez, Antonio Ramos-Martínez, Elena Múñez-Rubio, Isabel Sánchez-Romero, Juan Antonio Vargas Núñez
BACKGROUND AND OBJECTIVES: Pseudomonas aeruginosa bacteraemia is associated with a very high mortality, conditioned by comorbidity, source, severity of the episode and lack of adequate treatment. The aim of the study is to know the mortality and prognostic factors of bacteraemia by P.aeruginosa in our hospital. PATIENTS AND METHODS: We conducted a retrospective study of P.aeruginosa bacteraemia detected between 2009 and 2014. Epidemiological, clinical and microbiological characteristics were described...
June 6, 2018: Medicina Clínica
A P Douglas, K A Thursky, L J Worth, E Drummond, A Hogg, R J Hicks, M A Slavin
PURPOSE: Invasive fungal infections (IFIs) are common in immunocompromised patients. While early diagnosis can reduce otherwise high morbidity and mortality, conventional CT has suboptimal sensitivity and specificity. Small studies have suggested that the use of FDG PET/CT may improve the ability to detect IFI. The objective of this study was to describe the proven and probable IFIs detected on FDG PET/CT at our centre and compare the performance with that of CT for localization of infection, dissemination and response to therapy...
June 7, 2018: European Journal of Nuclear Medicine and Molecular Imaging
Michael O Mireku, Leslie L Davidson, Romeo Zoumenou, Achille Massougbodji, Michel Cot, Florence Bodeau-Livinec
OBJECTIVE: To investigate the relationship between prenatal geophagy, maternal prenatal haematological indices, malaria, helminth infections and cognitive and motor development among offspring. METHODS: At least a year after delivery, 552 of 863 HIV-negative mothers with singleton births who completed a clinical trial comparing the efficacy of sulfadoxine-pyrimethamine and mefloquine during pregnancy in Allada, Benin, responded to a nutrition questionnaire including their geophageous habits during pregnancy...
June 7, 2018: Tropical Medicine & International Health: TM & IH
Jeffrey Jones, Anthony Mato, Steven Coutre, John C Byrd, Richard R Furman, Peter Hillmen, Anders Osterborg, Constantine Tam, Stephan Stilgenbauer, William G Wierda, Nyla A Heerema, Karl Eckert, Fong Clow, Cathy Zhou, Alvina D Chu, Danelle F James, Susan M O'Brien
Patients with chronic lymphocytic leukaemia/small lymphocytic lymphoma (CLL/SLL) with deletion 17p [del(17p)] have poor outcomes with chemoimmunotherapy. Ibrutinib is indicated for the treatment of CLL/SLL, including del(17p) CLL/SLL, and allows for treatment without chemotherapy. This integrated analysis was performed to evaluate outcomes in 230 patients with relapsed/refractory del(17p) CLL/SLL from three ibrutinib studies. With a median of 2 prior therapies (range, 1-12), 18% and 79% of evaluable patients had del(11q) or unmutated IGHV, respectively...
June 5, 2018: British Journal of Haematology
Cho-Hao Lee, Chin Lin, Ching-Liang Ho, Jung-Chung Lin
Several new anti-fungal agents have become available for primary fungal prophylaxis of neutropenia fever in haematological malignancy patients. Our aim was to synthesize all evidence on efficacy and enable an integrated comparison of all current treatments.We performed a systematic literature review to identify all publicly available evidence from randomized controlled trials (RCT). We searched Embase, PubMed, the Cochrane Central Register of Controlled Clinical Trials, and the website In total, 54 RCTs were identified, including 13 treatment options...
June 4, 2018: Antimicrobial Agents and Chemotherapy
Jacob Moell, Anna Svenningsson, Margareta Af Sandeberg, Magnus Larsson, Mats Heyman, Arja Harila-Saari, Anna Nilsson
AIM: This study examined the clinical characteristics of central line associated blood stream infections occurring within 30 days after insertion versus later infections in paediatric cancer patients, and the subsequent risk for premature catheter removal. METHODS: This was a retrospective study of children aged 0-18 years who were diagnosed with cancer from 2013-2014 at the Astrid Lindgren Children Hospital, Sweden. Clinical and microbiology data for each patient was collected for 365 days after the central venous catheter was inserted...
June 4, 2018: Acta Paediatrica
E Focà, G Cavaglià, S Rusconi, A Cascavilla, G Cenderello, A Re, S Casari, L van den Bogaart, P L Zinzani, D Caracciolo, G Di Perri, A Bonito, A Lucchini, G Cassola, P Viale, A Calcagno
OBJECTIVES: Lymphoproliferative disorders are often observed in HIV-positive patients. Combination antiretroviral treatment (cART) during antineoplastic chemotherapy is beneficial, but little is known about the clinical outcome according to different antiretroviral combinations. The aim of the study was to address this gap in current knowledge. METHODS: A retrospective study was conducted in five large Italian centres for the period from 1998 to 2015; HIV-positive patients diagnosed with lymphoma were included and demographic, clinical and therapeutic variables were recorded and associated with clinical outcomes...
June 4, 2018: HIV Medicine
Alexander Egle, Michael Steurer, Thomas Melchardt, Lukas Weiss, Franz Josef Gassner, Nadja Zaborsky, Roland Geisberger, Kemal Catakovic, Tanja Nicole Hartman, Lisa Pleyer, Daniela Voskova, Josef Thaler, Alois Lang, Michael Girschikofsky, Andreas Petzer, Richard Greil
Despite recent advances, chemoimmunotherapy remains a standard for fit previously untreated chronic lymphocytic leukaemia patients. Lenalidomide had activity in early monotherapy trials, but tumour lysis and flare proved major obstacles in its development. We combined lenalidomide in increasing doses with six cycles of fludarabine and rituximab (FR), followed by lenalidomide/rituximab maintenance. In 45 chemo-naive patients, included in this trial, individual tolerability of the combination was highly divergent and no systematic toxicity determining a maximum tolerated dose was found...
June 4, 2018: Annals of Hematology
Kathryn E Ackerman, Bryan Holtzman, Katherine M Cooper, Erin F Flynn, Georgie Bruinvels, Adam S Tenforde, Kristin L Popp, Andrew J Simpkin, Allyson L Parziale
Low energy availability (EA) is suspected to be the underlying cause of both the Female Athlete Triad and the more recently defined syndrome, Relative Energy Deficiency in Sport (RED-S). The International Olympic Committee (IOC) defined RED-S as a syndrome of health and performance impairments resulting from an energy deficit. While the importance of adequate EA is generally accepted, few studies have attempted to understand whether low EA is associated with the health and performance consequences posited by the IOC...
June 2, 2018: British Journal of Sports Medicine
Jorge Cortes, Alexander E Perl, Hartmut Döhner, Hagop Kantarjian, Giovanni Martinelli, Tibor Kovacsovics, Philippe Rousselot, Björn Steffen, Hervé Dombret, Elihu Estey, Stephen Strickland, Jessica K Altman, Claudia D Baldus, Alan Burnett, Alwin Krämer, Nigel Russell, Neil P Shah, Catherine C Smith, Eunice S Wang, Norbert Ifrah, Guy Gammon, Denise Trone, Deborah Lazzaretto, Mark Levis
BACKGROUND: Old age and FMS-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) mutations in patients with acute myeloid leukaemia are associated with early relapse and poor survival. Quizartinib is an oral, highly potent, and selective next-generation FLT3 inhibitor with clinical antileukaemic activity in relapsed or refractory acute myeloid leukaemia. We aimed to assess the efficacy and safety of single-agent quizartinib in patients with relapsed or refractory acute myeloid leukaemia...
May 30, 2018: Lancet Oncology
Niels Obel, Ram B Dessau, Karen A Krogfelt, Jacob Bodilsen, Nanna S Andersen, Jens K Møller, Casper Roed, Lars H Omland, Claus B Christiansen, Svend Ellermann-Eriksen, Jette M Bangsborg, Klaus Hansen, Thomas L Benfield, Kenneth J Rothman, Henrik T Sørensen, Christian Ø Andersen, Anne-Mette Lebech
OBJECTIVE: To estimate long term survival, health, and educational/social functioning in patients with Lyme neuroborreliosis compared with the general population. DESIGN: Nationwide population based cohort study using national registers. SETTING: Denmark. PARTICIPANTS: All Danish residents diagnosed during 1986-2016 as having Lyme neuroborreliosis (n=2067), defined as a positive Borrelia burgdorferi intrathecal antibody test and a clinical diagnosis of Lyme borreliosis, and a comparison cohort from the general population matched on sex and date of birth (n=20 670)...
May 30, 2018: BMJ: British Medical Journal
Nirali Shah, Dhrubajyoti Borpojari, Kalyan Sarma, M Ayub Ali, Basanta Saikia, Hitesh Bayan, Fazal Ali Ahmed, Gunjan Das
An 8 years old male Burmese Red Serow ( Capricornis sumatraensis sub species rubidus ) from Aizawl Zoological Park was presented to the Teaching Veterinary Clinical Complex. An exploratory skin scraping revealed existence of nymphal as well as adult stages of mites of the Psoroptes spp. which were not associated with any overt lesions typical to mite infestation such as pruritus, erythema or scaling of the epidermis. The mites were identified as per their morphology, size and shape. Haemato-biochemical analysis revealed alteration of certain haematological and biochemical parameters...
June 2018: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
C Feben, T Wainstein, J Kromberg, F Essop, A Krause
Fanconi anaemia (FA) is an inherited genetic disorder characterised by somatic anomalies, bone marrow failure and an increased predisposition to solid tumours and haematological malignancies. South African (SA) black and Afrikaner individuals are at higher than average risk for this condition owing to genetic founder mutations in certain Fanconi-associated genes. This review explores the epidemiology, clinical presentation, diagnostic modalities and recommended care of affected patients, focusing on the founder population groups in SA...
April 25, 2018: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
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