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https://www.readbyqxmd.com/read/27831589/the-anti-inflammatory-vasostatin-2-attenuates-atherosclerosis-in-apoe-mice-and-inhibits-monocyte-macrophage-recruitment
#1
Weixin Xiong, Xiaoqun Wang, Daopeng Dai, Bao Zhang, Lin Lu, Rong Tao
We showed previously that reduced level of vasostatin-2 (VS-2) correlates to the presence and severity of coronary artery disease. In this study, we aimed to figure out the role of chromogranin A (CGA) derived VS-2 in the development of atherosclerosis and monocyte/macrophage recruitment. Apolipoprotein E-deficient (ApoE(-/-)) mice fed a high-fat diet exhibited attenuated lesion size by 65 % and 41 % in En face and aortic root Oil red O staining, MOMA-2 positive area by 64 %, respectively, in VS-2 treatment group compared with PBS group...
November 10, 2016: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/27595734/vasostatin-1-stops-structural-remodeling-and-improves-calcium-handling-via-the-enos-no-pkg-pathway-in-rat-hearts-subjected-to-chronic-%C3%AE-adrenergic-receptor-activation
#2
Dandan Wang, Yingguang Shan, Yan Huang, Yanhong Tang, Yuting Chen, Ran Li, Jing Yang, Congxin Huang
PURPOSE: Chronically elevated catecholamine levels activate cardiac β-adrenergic receptors, which play a vital role in the pathogenesis of heart failure. Evidence suggests that vasostatin-1 (VS-1) exerts anti-adrenergic effects on isolated and perfused hearts in vitro. Whether VS-1 ameliorates hypertrophy/remodeling by inducing the chronic activation of β-adrenergic receptors is unknown. The present study aims to test the efficacy of using VS-1 to treat the advanced hypertrophy/remodeling that result from chronic β-adrenergic receptor activation and to determine the cellular and molecular mechanisms that underlie this response...
October 2016: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/27531191/chromogranin-a-production-and-fragmentation-in-patients-with-takayasu-arteritis
#3
Enrico Tombetti, Barbara Colombo, Maria Chiara Di Chio, Silvia Sartorelli, Maurizio Papa, Annalaura Salerno, Enrica Paola Bozzolo, Elisabetta Tombolini, Giulia Benedetti, Claudia Godi, Chiara Lanzani, Patrizia Rovere-Querini, Alessandro Del Maschio, Alessandro Ambrosi, Francesco De Cobelli, Maria Grazia Sabbadini, Elena Baldissera, Angelo Corti, Angelo A Manfredi
BACKGROUND: Chromogranin-A (CgA) is a secretory protein processed into peptides that regulate angiogenesis and vascular cells activation, migration and proliferation. These processes may influence arterial inflammation and remodelling in Takayasu arteritis (TA). METHODS: Plasma levels of full-length CgA (CgA439), CgA fragments lacking the C-terminal region (CgA-FRs) and the N-terminal fragment, CgA1-76 (vasostatin-1, VS-1) were analysed in 42 patients with TA and 20 healthy age-matched controls...
2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27484122/catestatin-vasostatin-cortisol-temperature-heart-rate-respiratory-rate-scores-of-the-short-form-of-the-glasgow-composite-measure-pain-scale-and-visual-analog-scale-for-stress-and-pain-behavior-in-dogs-before-and-after-ovariohysterectomy
#4
Thanikul Srithunyarat, Odd V Höglund, Ragnvi Hagman, Ulf Olsson, Mats Stridsberg, Anne-Sofie Lagerstedt, Ann Pettersson
BACKGROUND: The stress reaction induced by surgery and associated pain may be detrimental for patient recovery and should be minimized. The neuropeptide chromogranin A (CGA) has shown promise as a sensitive biomarker for stress in humans. Little is known about CGA and its derived peptides, catestatin (CST) and vasostatin (VS), in dogs undergoing surgery. The objectives of this study were to investigate and compare concentrations of CGA epitopes CST and VS, cortisol, body temperature, heart rate, respiratory rate, scores of the short form of the Glasgow composite measure pain scale (CMPS-SF) and visual analog scales (VAS) for stress and pain behavior in dogs before and after ovariohysterectomy...
2016: BMC Research Notes
https://www.readbyqxmd.com/read/27395818/association-of-decreased-serum-vasostatin-2-level-with-ischemic-chronic-heart-failure-and-with-mace-in-3-year-follow-up-vasostatin-2-prevents-heart-failure-in-myocardial-infarction-rats
#5
Wen Qi Pan, Yu Hu He, Qian Su, Jie Yang, Yue Hua Fang, Feng Hua Ding, Xiao Xiang Yan, Zhu Hui Liu, Xiao Qun Wang, Ke Yang, Rui Yan Zhang, Wei Feng Shen, Feng Ru Zhang, Lin Lu
BACKGROUND: We investigated whether serum vasostatin-2 level is related to chronic heart failure (CHF) in patients with previous myocardial infarction (MI) and MACE in 3-year follow-up. The biological effect of vasostatin-2 on ischemic HF was evaluated in animal experiments. METHODS: After exclusion of the subjects not eligible, this study included 450 patients with CHF and previous MI, and 149 healthy controls. Serum vasostatin-2 level was analyzed. CHF patients were followed up for three years and major adverse cardiac events (MACE) were recorded, defined as reinfarction, target-vessel revascularization, cardiovascular death and refractory HF requiring hospitalizations...
October 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27203389/inhibition-of-chronic-lymphocytic-leukemia-progression-by-full-length-chromogranin-a-and-its-n-terminal-fragment-in-mouse-models
#6
Mimma Bianco, Anna Gasparri, Luca Generoso, Emma Assi, Barbara Colombo, Lydia Scarfò, Maria T S Bertilaccio, Cristina Scielzo, Pamela Ranghetti, Eleonora Dondossola, Maurilio Ponzoni, Federico Caligaris-Cappio, Paolo Ghia, Angelo Corti
Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of leukemic B cells in peripheral blood, bone marrow (BM) and lymphoid tissues, and by their recirculation between these compartments. We observed that circulating chromogranin A (CgA) and its N-terminal fragment (called vasostatin-1, CgA1-76), two neuroendocrine secretory polypeptides that enhance the endothelial barrier function, are present in variable amounts in the blood of CLL patients. Studies in animal models showed that daily administration of full-length human CgA1-439 (0...
July 5, 2016: Oncotarget
https://www.readbyqxmd.com/read/27185276/detection-of-vasostatin-1-specific-cd8-t-cells-in-non-obese-diabetic-mice-that-contribute-to-diabetes-pathogenesis
#7
E Nikoopour, O Krougly, E Lee-Chan, S M Mansour Haeryfar, B Singh
Chromogranin A (ChgA) is an antigenic target of pathogenic CD4(+) T cells in a non-obese diabetic (NOD) mouse model of type 1 diabetes (T1D). Vasostatin-1 is a naturally processed fragment of ChgA. We have now identified a novel H2-K(d) -restricted epitope of vasostatin-1, ChgA 36-44, which elicits CD8(+) T cell responses in NOD mice. By using ChgA 36-44/K(d) tetramers we have determined the frequency of vasostatin-1-specific CD8(+) T cells in pancreatic islets and draining lymph nodes of NOD mice. We also demonstrate that vasostatin-1-specific CD4(+) and CD8(+) T cells constitute a significant fraction of islet-infiltrating T cells in diabetic NOD mice...
September 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/26721428/vasostatin-2-inhibits-cell-proliferation-and-adhesion-in-vascular-smooth-muscle-cells-which-are-associated-with-the-progression-of-atherosclerosis
#8
Jianghong Hou, Xiaolin Xue, Junnong Li
Recently, the serum expression level of vasostatin-2 was found to be reduced and is being studied as an important indicator to assess the presence and severity of coronary artery disease; the functional properties of vasostatin-2 and its relationship with the development of atherosclerosis remains unclear. In this study, we attempted to detect the expression of vasostatin-2 and its impact on human vascular smooth muscle cells (VSMCs). Quantitative real-time PCR (qRT-PCR) and western blot were used to assess the expression level of vasostatin-2 in VSMCs between those from atherosclerosis and disease-free donors; we found that vasostatin-2 was significantly down-regulated in atherosclerosis patient tissues and cell lines...
January 22, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/25983374/altered-chromogranin-a-circulating-levels-in-meniere-s-disease
#9
Roberto Teggi, Barbara Colombo, Matteo Trimarchi, Mimma Bianco, Angelo Manfredi, Mario Bussi, Angelo Corti
OBJECTIVES: Meniere's disease (MD) is an inner ear disorder characterized by episodic vertigo, ear fullness, and hearing loss; usually vertigo attacks cluster in specific period. We studied in MD patients the circulating levels of chromogranin A (CgA) and vasostatin-1 (VS-1), secreted by the neuroendocrine system and involved in the regulation of the endothelial barrier function. METHODS: Serum levels were assessed in 37 MD patients and 36 controls. The ratio between VS-1 and CgA was calculated...
2015: Disease Markers
https://www.readbyqxmd.com/read/25297920/chromogranin-a-a-paradoxical-player-in-angiogenesis-and-vascular-biology
#10
REVIEW
Karen B Helle, Angelo Corti
Half a century after the discovery of chromogranin A as a secreted product of the catecholamine storage granules in the bovine adrenal medulla, the physiological role for the circulating pool of this protein has been recently coined, namely as an important player in vascular homeostasis. While the circulating chromogranin A since 1984 has proved to be a significant and useful marker of a wide range of pathophysiological and pathological conditions involving the diffuse neuroendocrine system, this protein has now been assigned a physiological "raison d'etre" as a regulator in vascular homeostasis...
January 2015: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/25271003/effect-of-chromogranin-a-derived-vasostatin-1-on-laser-induced-choroidal-neovascularization-in-the-mouse
#11
Silvia Maestroni, Anna Maestroni, Simona Ceglia, Gemma Tremolada, Monica Mancino, Angelina Sacchi, Rosangela Lattanzio, Ilaria Zucchiatti, Angelo Corti, Francesco Bandello, Gianpaolo Zerbini
PURPOSE: To verify the effect of vasostatin-1 (VS-1), an anti-angiogenic fragment of chromogranin A, in the prevention of choroidal neovascularization (CNV) in an established mouse model of laser-induced ocular neovascularization. METHODS: Bruch's membrane, the innermost layer of the choroid, was broken by laser photocoagulation in C57/Bl6 mice, to induce CNV. Mice were then treated daily for 14 days by intraperitoneal injection of VS-1 or vehicle (6 mice/group)...
May 2015: Acta Ophthalmologica
https://www.readbyqxmd.com/read/25177680/the-surging-role-of-chromogranin-a-in-cardiovascular-homeostasis
#12
REVIEW
Bruno Tota, Tommaso Angelone, Maria C Cerra
Together with Chromogranin B and Secretogranins, Chromogranin A (CGA) is stored in secretory (chromaffin) granules of the diffuse neuroendocrine system and released with noradrenalin and adrenalin. Co-stored within the granule together with neuropeptideY, cardiac natriuretic peptide hormones, several prohormones and their proteolytic enzymes, CGA is a multifunctional protein and a major marker of the sympatho-adrenal neuroendocrine activity. Due to its partial processing to several biologically active peptides, CGA appears an important pro-hormone implicated in relevant modulatory actions on endocrine, cardiovascular, metabolic, and immune systems through both direct and indirect sympatho-adrenergic interactions...
2014: Frontiers in Chemistry
https://www.readbyqxmd.com/read/24997628/plasmid-encoding-vasostatin-inhibited-the-growth-and-metastasis-of-human-hepatocellular-carcinoma-cells
#13
Xing-Chen Peng, Ming Wang, Xu-Xia Chen, Jing Liu, Gui-Hua Xiao, Hong-Li Liao
The growth and metastasis of solid tumors depends on angiogenesis. Anti-angiogenesis therapy may represent a promising therapeutic option. Vasostatin, the N-terminal domain of calreticulin, is a very potent endogenous inhibitor of angiogenesis and tumor growth. In this study, we attempted to investigate whether plasmid-encoding vasostatin complexed with cationic liposome could suppress the growth and metastasis of hepatocellular carcinoma in vivo and discover its possible mechanism of action. Apoptosis induction of pSecTag2B-vasostatin plasmid on murine endothelial cells (MS1) was examined by flow cytometric analysis in vitro...
October 2014: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/24942148/inhibition-of-angiogenesis-by-a-synthetic-fusion-protein-vtf-derived-from-vasostatin-and-tumstatin
#14
Quliang Gu, Cihuang Sun, Jinxian Luo, Tianyuan Zhang, Lijing Wang
The inhibition of angiogenesis represents a potential strategy for antitumor therapy. A novel synthetic fusion protein VTF, composed of bioactive fragments from two different angiogenesis inhibitors, vasostatin and tumstatin with a (Gly-Ser-Gly)2 bridge, was generated using the pET-15b expression vector. The fusion protein VTF showed significantly enhanced efficacy in inhibiting human endothelial cell proliferation and tube formation and neovascularization on chick embryo chorioallantoic membrane. Moreover, VTF suppressed the growth of B16 melanoma and the formation of tumor blood vessels potently in vivo...
October 2014: Anti-cancer Drugs
https://www.readbyqxmd.com/read/24722573/vasostatin-inhibits-vegf-induced-endothelial-cell-proliferation-tube-formation-and-induces-cell-apoptosis-under-oxygen-deprivation
#15
Qun Shu, Wenjiao Li, Haichuan Li, Gang Sun
Anti-angiogenesis treatment has been a promising new form of cancer therapy. Endothelial cells are critical for vascular homeostasis and play important roles in angiogenesis, vascular and tissue remodeling. Vasostatin, the 180 amino acid N-terminal fragment of the calreticulin protein, is reported to be a potent endogenous inhibitor of angiogenesis, suppressing tumor growth. However, the mechanism of these effects has not been sufficiently investigated. This study was performed to investigate the possible mechanism of vasostatin effects on primary cultured human umbilical vein endothelial cells (HUVEC)...
2014: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/24671122/biological-function-and-clinical-relevance-of-chromogranin-a-and-derived-peptides
#16
Maria Angela D'amico, Barbara Ghinassi, Pascal Izzicupo, Lamberto Manzoli, A Di Baldassarre
Chromogranin A (CgA (CHGA)) is the major soluble protein co-stored and co-released with catecholamines and can function as a pro-hormone by giving rise to several bioactive peptides. This review summarizes the physiological functions, the pathogenic implications, and the recent use of these molecules as biomarkers in several pathological conditions. A thorough literature review of the electronic healthcare databases MEDLINE, from January 1985 to September 2013, was conducted to identify articles and studies concerned with CgA and its processing...
2014: Endocrine Connections
https://www.readbyqxmd.com/read/24665742/-cardiovascular-effects-and-pathophysiological-significance-of-vasostatins
#17
Xiao-Jing Cui, Lei Meng, Wen-Hui Ding
No abstract text is available yet for this article.
December 2013: Sheng Li Ke Xue Jin Zhan [Progress in Physiology]
https://www.readbyqxmd.com/read/24443235/vasostatin-1-antigenic-epitope-mapping-for-induction-of-cellular-and-humoral-immune-responses-to-chromogranin-a-autoantigen-in-nod-mice
#18
Enayat Nikoopour, Rebecca Cheung, Stacey Bellemore, Olga Krougly, Edwin Lee-Chan, Mats Stridsberg, Bhagirath Singh
The chromogranin A (ChgA) 29-42 sequence is the antigenic epitope for the BDC2.5 CD4(+) T-cell receptor in NOD mice (H-2(g7) ). We have now characterized the binding register of the ChgA 29-42 peptide for the I-A(g7) molecule. Truncation of the peptide demonstrated that the KCVLEVISD sequence 34-42 is the binding register and extension of this sequence by flanking residues increased its binding affinity and antigenic capacity. We employed anti-ChgA peptide antibodies generated against different fragments of ChgA for immunostaining of pancreatic islet sections from NOD mice...
April 2014: European Journal of Immunology
https://www.readbyqxmd.com/read/24260544/chromogranin-a-and-its-fragments-as-regulators-of-small-intestinal-neuroendocrine-neoplasm-proliferation
#19
Francesco Giovinazzo, Simon Schimmack, Bernhard Svejda, Daniele Alaimo, Roswitha Pfragner, Irvin Modlin, Mark Kidd
INTRODUCTION: Chromogranin A is a neuroendocrine secretory product and its loss is a feature of malignant NEN de-differentiation. We hypothesized that chromogranin A fragments were differentially expressed during NEN metastasis and played a role in the regulation of NEN proliferation. METHODS: Chromogranin A mRNA (PCR) and protein (ELISA/western blot) were studied in 10 normal human mucosa, 5 enterochromaffin cell preparations, 26 small intestinal NEN primaries and 9 liver metastases...
2013: PloS One
https://www.readbyqxmd.com/read/24205998/the-comparison-of-endogenous-angiogenesis-inhibitors-in-normotensive-and-preeclamptic-placentas-an-immunohistochemical-study
#20
COMPARATIVE STUDY
Ercan Ayaz, Yusuf Nergiz, Selcuk Tunik, Ahmet Yalinkaya
OBJECTIVE: Recently, it has been reported that endogenous angiogenesis inhibitors play a key role in the pathophysiology of preeclampsia. Thrombospondin-1, angiostatin and vasostatin are endogenous angiogenesis inhibitors and so far have not been shown in placenta at the immunohistochemical level. The aim of this study was to compare staining patterns of these endogenous angiogenesis inhibitors immunohistochemically in placentas of preeclamptic and normotensive pregnant women. METHODS: Into the study, placentas from 20 preeclamptic and 20 normotensive pregnant women were included...
February 2014: Hypertension in Pregnancy
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