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https://www.readbyqxmd.com/read/29902806/effect-of-physical-exercise-on-platelet-reactivity-in-patients-with-dual-antiplatelet-therapy
#1
Stefan Brunner, Konstantinos Rizas, Wolfgang Hamm, Michael Mehr, Korbinian Lackermair
It is known that physical exercise may increase platelet activity. However, the effect of exercise on platelet reactivity in patients on dual antiplatelet therapy has not been investigated yet. In our study, 21 patients with coronary artery disease on dual antiplatelet therapy and 10 controls were enrolled. We performed an exercise test using a cycle ergometer and determined the adenosine diphosphate-induced platelet reactivity before and immediately after exercise testing. Additionally, we analysed maximal exercise capacity and an electrocardiogram...
June 14, 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29901633/primary-small-cell-carcinoma-of-the-ureter-case-report-and-review-of-the-literature
#2
Fabiola Farci, Francesca Manassero, Ramona Baldesi, Annamaria Bartolucci, Laura Boldrini, Cesare Selli, Pinuccia Faviana
RATIONALE: Primitive small cell carcinoma of the ureter is extremely rare, in this case report is meticulously described its aggressive clinical course and the pathological clues that help with the diagnosis. Also, a detailed table with the clinico-pathological features of analogous case reports in literature is provided. PATIENT CONCERNS: A 79-year-old female presented with gross hematuria and flank pain. DIAGNOSES: Small cell carcinoma of the ureter...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29894516/immunohistochemical-panel-to-characterize-canine-prostate-carcinomas-according-to-aberrant-p63-expression
#3
Carlos Eduardo Fonseca-Alves, Priscila Emiko Kobayashi, Luis Gabriel Rivera Calderón, Sérgio Luis Felisbino, Jaqueline de Carvalho Rinaldi, Sandra Aparecida Drigo, Silvia Regina Rogatto, Renée Laufer-Amorim
An unusual variant of prostate adenocarcinoma (PC) expressing nuclear p63 in secretory cells instead of the typical basal expression has been reported in men. Nevertheless, the biological behavior and clinical significance of this phenomenon is unknown. In dogs, this unusual PC subtype has not been described. In this study, p63 immunoexpression was investigated in 90 canine PCs and 20 normal prostate tissues (NT). The p63 expression pattern in luminal or basal cells was confirmed in a selected group of 26 PCs and 20 NT by immunohistochemistry and/or Western blotting assays...
2018: PloS One
https://www.readbyqxmd.com/read/29894357/primary-visceral-merkel-cell-carcinoma-a-case-report-and-review-of-the-literature
#4
Andrew Siref, Bonnie Balzer, Andrew Hendifar
A 63-year-old white man with no significant previous medical or surgical history presented with painless jaundice after 3 weeks of dark urine, yellow stools, and a 9-pound weight loss. Bilirubin, aspartate transaminase, alanine transaminase, and alkaline phosphatase were elevated, and a computed tomography scan detected a 10-cm, ill-defined mass at the porta hepatis compressing the common bile duct. He underwent endoscopic retrograde cholangiopancreatography with stenting and ultrasound-guided biopsies. Histologic sections showed a neoplastic population of small ovoid cells with a high N:C ratio, nuclear hyperchromasia, "smoky" chromatin and abundant mitotic figures, and characteristic of high-grade neuroendocrine carcinoma (HGNECA)...
June 7, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29888815/merkel-cell-polyomavirus-integration-pcr-in-bilateral-metachronous-merkel-cell-carcinoma-on-the-nose
#5
Susanne Hanner, Ulrike Wieland, Wolfgang Hartschuh, Alexander Enk, Ferdinand Toberer
An 81-year-old woman presented with a several weeks history of an erythematous tumour at her right nostril (Figure 1a). The tumour was surgically removed. Histopathology showed peritumoral clefts and BerEP4-expression consistent with basal cell carcinoma (Figure 2a). One year later the patient developed a small erythematous tumour at the left nostril (Figure 1b). Histopathology was consistent with a diagnosis of Merkel cell carcinoma (MCC) (Figure 2c,d). The tumour was removed using Mohs micrographic surgery...
June 11, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29886587/-histologic-subtyping-of-poorly-differentiated-solid-lung-cancer-with-molecular-testing-for-epidermal-growth-factor-receptor-mutation-and-alk-gene-rearrangement-an-analyses-of-167-cases
#6
F Fang, Y X Wang, S T Hu, L Yang, J Di, D G Liu, N Lyu
Objective: To study the histological subtyping of poorly differentiated solid lung cancer by using immunohistochemistry and mucin staining along with analysis of epidermal growth factor receptor (EGFR) mutation and anaplastic lymphoma kinase (ALK) gene rearrangement. Methods: Among 827 cases of non-small cell lung cancer at Beijing Hospital from April 2014 to April 2017, 167 cases of solid poorly differentiated lung cancer were identified and histopathologically subtyped by mucin staining (D-PAS) and immunohistochemistry using 10 antibodies (CK7, vimentin, Ki-67, CK5/6, p40, TTF1, Napsin A, CD56, chromogranin A, and synaptophysin)...
June 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29885405/insulinoma-associated-protein-1-is-a-novel-sensitive-and-specific-marker-for-small-cell-carcinoma-of-the-prostate
#7
Wei Xue, Zhixiang Xin, Yong Zhang, Zhou Jiang, Ling Zhao, Liancheng Fan, Yanqing Wang, Shaowei Xie, Xun Shangguan, Yinjie Zhu, Jiahua Pan, Qiang Liu, Yiran Huang, Baijun Dong
The correct diagnosis of small cell carcinoma (SCC) of the prostate is critical because of its aggressive behavior and poor prognosis. The histopathologic diagnosis could be challenging without neuroendocrine markers, which currently has limitations. Insulinomaassociated protein 1 (INSM1), a zinc-finger transcription factor, is considered to play an important role in the development of several neuroendocrine precursor cells. Its diagnosis value has only recently been evaluated. In this study, we analyzed the expression of INSM in three high-throughput RNA sequencing data sets and performed INSM1 immunohistochemistry on a large series of prostatic SCCs and nonneuroendocrine prostate tissues...
June 6, 2018: Human Pathology
https://www.readbyqxmd.com/read/29882219/endocrine-mucin-producing-sweat-gland-carcinoma-clinicopathologic-immunohistochemical-and-molecular-analysis-of-eleven-cases-with-emphasis-on-myb-immunoexpression
#8
L Held, A Ruetten, H Kutzner, G Palmedo, B John, T Mentzel
BACKGROUND: Endocrine mucin-producing sweat gland carcinoma (EMPSGC) is a rare low-grade primary cutaneous sweat gland carcinoma with predilection for the periorbital skin in elderly female patients. METHODS: We describe eleven cases of EMPSGC using a broad panel of immunohistochemical markers including BerEP4, cytokeratin 7, CAM 5.2; synaptophysin, chromogranin, cytokeratin 20, Ki67, progesterone receptor, and estrogen receptor. Calponin (1A4) and p63 were used to detect surrounding myoepithelial cells...
June 7, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29866603/salivary-biomarkers-for-the-diagnosis-and-monitoring-of-neurological-diseases
#9
REVIEW
Raymond Farah, Hayat Haraty, Ziad Salame, Youssef Fares, David M Ojcius, Najwane Said Sadier
Current research efforts on neurological diseases are focused on identifying novel disease biomarkers to aid in diagnosis, provide accurate prognostic information and monitor disease progression. With advances in detection and quantification methods in genomics, proteomics and metabolomics, saliva has emerged as a good source of samples for detection of disease biomarkers. Obtaining a sample of saliva offers multiple advantages over the currently tested biological fluids as it is a non-invasive, painless and simple procedure that does not require expert training or harbour undesirable side effects for the patients...
April 2018: Biomedical Journal
https://www.readbyqxmd.com/read/29862475/importance-of-immunohistochemical-detection-of-somatostatin-receptors
#10
Attila Zalatnai, Eszter Galambos, Eszter Perjési
The long-acting somatostatin analogs represent important weapons in treatment protocols of patients with neuroendocrine tumors. Because these peptides preferentially bind to the specific somatostatin receptors, the targeted therapy requires detection of them. As one of the national consulting centers, here we present the results of the immunohistochemically positive neuroendocrine neoplasms diagnosed between 2010 and 2014. Twenty-four paraffin-embedded cases (14 females 10 men, 21-79 years) from different localizations were found to express somatostatin-receptor type 2 (SSTR2)...
June 3, 2018: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/29858590/serum-chromogranin-a-based-prognosis-in-metastatic-castration-resistant-prostate-cancer
#11
Karthik V Giridhar, Cristobal Sanhueza, David W Hillman, Hassan Alkhateeb, Rachel Carlson, Winston Tan, Brian A Costello, Fernando Quevedo, Lance Pagliaro, Manish Kohli
OBJECTIVE: To determine the prognostic value of serum chromogranin-A (CGA) in a two-cohort study of men with metastatic castrate resistant prostate cancer (mCRPC) and to compare with circulating tumor cells (CTCs)-based prognosis. PATIENTS AND METHODS: A two-cohort-based evaluation for serum CGA for prognostication in CRPC stage was performed using a screening cohort of 256 men with mCRPC and an independent validation cohort of 92 men with mCRPC. In both cohorts, men receiving proton pump inhibitors and those with non-castrate levels of testosterone (>50 ng/dl) were excluded...
June 1, 2018: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29850019/oral-lactoferrin-influences-psychological-stress-in-humans-a-single-dose-administration-crossover-study
#12
Tokiko Shinjo, Keishoku Sakuraba, Atsuko Nakaniida, Tomoyo Ishibashi, Miki Kobayashi, Yuya Aono, Yoshio Suzuki
Lactoferrin is a secretory protein with various physiological functions. Bovine lactoferrin has been demonstrated to alleviate psychological stresses in rats, but this effect in humans has not yet been assessed. The present study aimed to investigate the changes in psychological stress markers following a calculation task, with either lactoferrin or a placebo orally administered prior to the task. A total of 16 healthy female college students visited Juntendo University, Inzai, Japan following an overnight fast...
May 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29843922/embryonal-brain-tumor-with-unknown-primary-lesion-and-massive-cerebrospinal-fluid-dissemination-a-case-report
#13
Hirotomo Tanaka, Daisuke Yamamoto, Mitsuru Ikeda, Masashi Morikawa, Kayo Ueda, Kazuhiro Tanaka, Takashi Sasayama, Eiji Kohmura
The 2007 World Health Organization Classification of Tumors of the Central Nervous System (CNS) categorized embryonal tumors of the CNS into three classes: medulloblastoma, CNS primitive neuroectodermal tumor, and atypical teratoid/rhabdoid tumor. Due to the lack of specific histological features, it was sometimes difficult to accurately differentiate CNS embryonal tumors pathologically. Here, we report a case of a young man, who presented with headache. Gadolinium-enhanced magnetic resonance imaging demonstrated massive lesions in the cerebrospinal fluid space, which strongly suggested leptomeningeal dissemination of a brain tumor...
May 26, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29807524/exploring-the-possible-prognostic-role-of-b-lymphocyte-stimulator-blys-in-a-large-series-of-patients-with-neuroendocrine-tumors
#14
Franco Grimaldi, Fabio Vescini, Veronica Tonelli, Cinzia Pistis, Elda Kara, Vincenzo Triggiani, Elio Tonutti, Francesco Curcio, Martina Fabris
BACKGROUND AND OBJECTIVE: BLyS (B-Lymphocyte stimulator) is over-expressed in several tumoral settings, with direct or indirect effects on neoplastic proliferation and possibly representing a therapeutic target. In this study we explored the role of BLyS in a large population of patients with neuroendocrine tumors (NETs). METHODS: The study analyzed the stored sera of 124 consecutive unselected patients with NETs: 36 lung carcinoids (24 typical, 12 atypical), 47 gastroenteric tract and 41 pancreatic (30 non-functioning and 11 functioning: 9 insulinomas, 2 glucagonomas)...
May 28, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29805630/low-accuracy-of-chromogranin-a-for-diagnosing-early-stage-pancreatic-neuroendocrine-tumors
#15
Chao-Ming Tseng, Tsu-Yao Cheng, Tai-Been Chen, Yu-Wen Tien, Chien-Chuan Chen, Jaw-Town Lin, Hsiu-Po Wang
The aim of the present study was to evaluate the clinical utility of plasma chromogranin A (CgA) in patients diagnosed with early-stage pancreatic neuroendocrine tumors (PNETs) in terms of diagnostic value and treatment response. A total of 35 patients with PNETs were prospectively enrolled from August 2010 to April 2014. Demographic and clinicopathological data were collected, and serial plasma CgA levels were measured. Tumor responses were defined by the Response Evaluation Criteria In Solid Tumors criteria...
June 2018: Oncology Letters
https://www.readbyqxmd.com/read/29803758/increase-in-chromogranin-a-and-serotonin-positive-cells-in-pouch-mucosa-of-patients-with-ulcerative-colitis-undergoing-proctocolectomy
#16
Paolo Giuffrida, Alessandro Vanoli, Elena Biletta, Catherine Klersy, Gaetano Bergamaschi, Gianluca M Sampietro, Sandro Ardizzone, Ombretta Luinetti, Michele Martino, Marco Vincenzo Lenti, Nicola Aronico, Marco Curti, Rachele Manca, Paolo Fociani, Marta Truffi, Fabio Corsi, Gino Roberto Corazza, Antonio Di Sabatino
BACKGROUND: Inflammatory bowel disease (IBD) is associated with neuroendocrine cell hyperplasia. AIMS: We investigated neuroendocrine cells in J-pouches of patients with ulcerative colitis undergoing restorative proctocolectomy and ileal pouch-anal anastomosis. METHODS: Sections from pouch biopsies of 17 patients and ileal biopsies of 17 active IBD patients and 16 controls were processed by immunohistochemistry for chromogranin A (CgA) and serotonin...
April 28, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29788534/prospective-evaluation-of-68-ga-dotatate-pet-ct-in-limited-disease-neuroendocrine-tumors-and-or-elevated-serum-neuroendocrine-biomarkers
#17
Sophie Gabriel, Philippe Garrigue, Laetitia Dahan, Frédéric Castinetti, Frédéric Sebag, Karine Baumstark, Cendrine Archange, Jha Abhishek, Karel Pacak, Benjamin Guillet, David Taïeb
CONTEXT: The 68 Ga-labelled somatostatin analogues (68 Ga-DOTA-SSAs) is becoming popular as an important diagnostic tool in neuroendocrine tumors as evidenced by a growing number of reports detailing institutional experience with various DOTA peptides. However, only few prospective studies have compared 68 Ga-DOTA-SSAs and somatostatin receptor scintigraphy (SRS) in gastroenteropancreatic neuroendocrine tumors (GEP-NETs) and pulmonary neuroendocrine tumors. OBJECTIVE: The aim of our prospective study was to perform head-to-head comparison between 68 Ga-DOTATATE PET/CT and standard imaging work-up (SI) that included multiphasic CT, liver MRI, and SRS using single photon emission computed tomography...
May 22, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29787820/clinicopathological-characteristics-of-thyroid-transcription-factor-1-negative-small-cell-lung-cancers
#18
Yuko Iida, Shinobu Masuda, Yoko Nakanishi, Tetsuo Shimizu, Haruna Nishimaki, Mai Takahashi, Mari Hikichi, Shuichiro Maruoka, Yasuhiro Gon, Noriaki Takahashi, Shu Hashimoto
Limitations in obtaining surgically resected or biopsy samples of small cell lung cancer (SCLC) tumors make comprehensive biological analyses difficult. The loss of thyroid transcription factor 1 (TTF-1) has been associated with the aggressive behavior of non-small cell lung cancer (NSCLC); however, clinicopathological features of TTF-1-negative SCLC remain unclear. This study aimed to elucidate the characteristics of TTF-1-negative SCLC. We studied the associations between the expression of TTF-1 and the clinicopathological factors associated with SCLC, including survival and expression of neuroendocrine markers (synaptophysin, chromogranin A, and CD56), neuroendocrine cell-specific transcription factors (achaete-scute homolog like 1 (ASCL1), BRN2), a proliferation marker (Ki-67 labeling index), and an oncogene (Nuclear Factor 1B (NF1B))...
May 19, 2018: Human Pathology
https://www.readbyqxmd.com/read/29763719/small-cell-carcinoma-of-the-urinary-bladder-a-clinicopathologic-and-immunohistochemical-analysis-of-81-cases
#19
Gang Wang, Li Xiao, Miao Zhang, Ashish M Kamat, Arlene Siefker-Radtke, Colin P Dinney, Bogdan Czerniak, Charles C Guo
Small cell carcinoma (SmCC) of the bladder is a rare disease. We retrospectively studied a large series of bladder SmCC from a single institution. The patients included 69 men and 12 women with a mean age of 68years. Most bladder SmCC were presented at advanced stage with tumors invading the muscularis propria and beyond (n=77). SmCC was pure in 27 cases and mixed with other histologic types in 54 cases, including urothelial carcinoma (UC) (n=32), UC in situ (n=26), glandular (n=14), micropapillary (n=4), sarcomatoid (n=4), and squamous (n=3), and plasmacytoid (n=1) features...
May 12, 2018: Human Pathology
https://www.readbyqxmd.com/read/29747899/central-neurocytoma-represents-a-tumor-consisting-of-diverse-neuronal-phenotypes
#20
Branavan Manoranjan, John P Provias
Central neurocytoma (CN) has long been regarded as a neuronal tumor based on the immunohistochemical expression of synaptophysin and the ultrastructural observation of neurosecretory granules, neurites, and synapses. Having diagnosed 11 CNs at our institution over the past thirty years, we set out to conduct an immunohistochemical study to assess the expression profile of neuronal markers across our cases. Markers of interest included synaptophysin, alpha-synuclein, chromogranin, neurofilament, and calretinin...
May 7, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
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