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Orthobiologics

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https://www.readbyqxmd.com/read/29604438/porous-calcium-phosphate-glass-microspheres-for-orthobiologic-applications
#1
Kazi M Zakir Hossain, Uresha Patel, Andrew Kennedy, Laura Macri-Pellizzeri, Virginie Sottile, David M Grant, Brigitte E Scammell, Ifty Ahmed
Orthobiologics is a rapidly advancing field utilising cell-based therapies and biomaterials to enable the body to repair and regenerate musculoskeletal tissues. This paper reports on a cost-effective flame spheroidisation process for production of novel porous glass microspheres from calcium phosphate-based glasses to encapsulate and deliver stem cells. Careful selection of the glass and pore-forming agent, along with a manufacturing method with the required processing window enabled the production of porous glass microspheres via a single-stage manufacturing process...
March 28, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29521582/the-role-of-rehabilitation-after-regenerative-and-orthobiologic-procedures-for-the-treatment-of-tendinopathy-a-systematic-review
#2
Walter I Sussman, Ken Mautner, Gerard Malanga
AIM: Significant variability exists in the literature, with no clear consensus to the optimal protocol after a regenerative procedure. Given this uncertainty, the authors systematically reviewed the literature cataloging the different variables that may influence outcomes. METHODS: Search was limited to randomized clinical trials and prospective cohort studies of regenerative procedures for the treatment of tendinopathy. Variables were predetermined, and included: cyrotherapy, pre- and post-procedure nonsteroidal anti-inflammatory drugs use, recommendations for alternative pain medications, immobilization and duration of rest...
March 2018: Regenerative Medicine
https://www.readbyqxmd.com/read/29357301/delivery-of-cellular-factors-to-regulate-bone-healing
#3
Alexander Haumer, Paul Emile Bourgine, Paola Occhetta, Gordian Born, Roberta Tasso, Ivan Martin
Bone tissue has a strong intrinsic regenerative capacity, thanks to a delicate and complex interplay of cellular and molecular processes, which tightly involve the immune system. Pathological settings of anatomical, biomechanical or inflammatory nature may lead to impaired bone healing. Innovative strategies to enhance bone repair, including the delivery of osteoprogenitor cells or of potent cytokines/morphogens, indicate the potential of 'orthobiologics', but are not fully satisfactory. Here, we review different approaches based on the delivery of regenerative cues produced by cells but in cell-free, possibly off-the-shelf configurations...
January 21, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29276433/cell-based-approaches-for-augmentation-of-tendon-repair
#4
Camila B Carballo, Amir Lebaschi, Scott A Rodeo
Cell-based approaches are among the principal interventions in orthobiologics to improve tendon and ligament healing and to combat degenerative processes. The number of options available for investigation are expanding rapidly and investigators have an increasing number of cell types to choose from for research purposes. However, in part due to the current regulatory environment, the list of available cells at clinicians' disposal for therapeutic purposes is still rather limited. In this review, we present an overview of the main cellular categories in current use...
September 2017: Techniques in Shoulder & Elbow Surgery
https://www.readbyqxmd.com/read/29208211/plasma-firocoxib-concentrations-after-intra-articular-injection-of-autologous-conditioned-serum-prepared-from-firocoxib-positive-horses
#5
K F Ortved, M B Goodale, C Ober, G A Maylin, L A Fortier
Orthobiologics such as autologous conditioned serum (ACS) are often used to treat joint disease in horses. Because ACS is generated from the horse's own blood, any medication administered at the time of preparation would likely be present in stored ACS, which could lead to an inadvertent positive drug test following intra-articular (IA) injection. The main objective of this study was to determine if ACS prepared from firocoxib positive horses could result in detectable plasma concentrations of the drug following IA injection...
December 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28979900/comparison-of-the-effects-of-interleukin-1-on-equine-articular-cartilage-explants-and-cocultures-of-osteochondral-and-synovial-explants
#6
Christopher R Byron, Richard A Trahan
Osteoarthritis (OA) is a ubiquitous disease affecting many horses. The disease causes chronic pain and decreased performance for patients and great cost to owners for diagnosis and treatment. The most common treatments include systemic non-steroidal anti-inflammatory drugs and intra-articular injection of corticosteroids. There is excellent support for the palliative pain relief these treatments provide; however, they do not arrest progression and may in some instances hasten advancement of disease. Orthobiologic treatments have been investigated as potential OA treatments that may not only ameliorate pain but also prevent or reverse pathologic articular tissue changes...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28938891/treatment-of-lumbar-degenerative-disc-disease-associated-radicular-pain-with-culture-expanded-autologous-mesenchymal-stem-cells-a-pilot-study-on-safety-and-efficacy
#7
Christopher Centeno, Jason Markle, Ehren Dodson, Ian Stemper, Christopher J Williams, Matthew Hyzy, Thomas Ichim, Michael Freeman
BACKGROUND: Degenerative disc disease (DDD) is a common cause of lower back pain with radicular symptoms and has a significant socioeconomic impact given the associated disability. Limited effective conservative therapeutic options result in many turning to surgical alternatives for management, which vary in the rate of success and also carry an increased risk of morbidity and mortality associated with the procedures. Several animal based studies and a few human pilot studies have demonstrated safety and suggest efficacy in the treatment of DDD with mesenchymal stem cells (MSCs)...
September 22, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28736619/the-role-of-orthobiologics-in-foot-and-ankle-surgery-allogenic-bone-grafts-and-bone-graft-substitutes
#8
REVIEW
James Wee, Gowreeson Thevendran
Orthobiologics are biological substances that are used therapeutically for their positive effects on healing skeletal and soft-tissue injuries. The array of orthobiological products currently available to the foot and ankle surgeon is wide, and includes bone allografts, bone substitutes, growth factors, and chondral scaffolds. Nonetheless, despite the surge in interest and usage of orthobiologics, there remains a relative paucity of research addressing their specific applications in foot and ankle surgery. In this review, we attempt to provide an overview of the literature on commonly available allogenic bone grafts and bone substitutes...
June 2017: EFORT Open Reviews
https://www.readbyqxmd.com/read/28577787/orthobiologics
#9
EDITORIAL
Frederick M Azar
No abstract text is available yet for this article.
July 2017: Orthopedic Clinics of North America
https://www.readbyqxmd.com/read/28577785/osseous-healing-in-foot-and-ankle-surgery-with-autograft-allograft-and-other-orthobiologics
#10
REVIEW
Jane C Yeoh, Brandon A Taylor
In the surgical treatment of foot and ankle abnormality, many problems require bone grafting for successful osseous union. Nonunion, reconstruction, and arthrodesis procedures pose specific challenges due to bony defects secondary to trauma, malunions, or previous surgery. Nonunion in foot and ankle arthrodesis is a significant risk and is well documented in recent literature. This article is a review of the recent literature regarding the use of bone graft and orthobiologics in foot and ankle surgery.
July 2017: Orthopedic Clinics of North America
https://www.readbyqxmd.com/read/28577784/autologous-blood-and-platelet-rich-plasma-injections-for-treatment-of-lateral-epicondylitis
#11
REVIEW
James H Calandruccio, Murphy M Steiner
Lateral epicondylitis (tennis elbow) is a frequent cause of elbow pain; most patients (80%-90%) are successfully treated with standard nonoperative methods (rest, nonsteroidal anti-inflammatory drugs, bracing, and physical therapy). Autologous blood injections and platelet-rich plasma injections are the two most frequently used orthobiologic techniques in the treatment of lateral epicondylitis. Studies of the effectiveness of autologous blood injections and platelet-rich plasma report varying outcomes, some citing significant clinical relief and others reporting no beneficial effect...
July 2017: Orthopedic Clinics of North America
https://www.readbyqxmd.com/read/28577783/biologic-approaches-to-problems-of-the-hand-and-wrist
#12
REVIEW
Murphy M Steiner, James H Calandruccio
Orthobiologics are not used as frequently in the hand and wrist as in other sites. The most frequently reported is the use of bone morphogenetic protein for the treatment of Kienböck disease. Animal studies have described improved tendon healing with the use of platelet-rich plasma (PRP), but no clinical studies have confirmed these results. PRP has been reported to produce improvements in the outcomes of distal radial fractures and osteoarthritis of the trapeziometacarpal in small numbers of patients. The use of orthobiologics in the hand and wrist are promising, but clinical trials are necessary to establish efficacy and safety...
July 2017: Orthopedic Clinics of North America
https://www.readbyqxmd.com/read/28577782/orthobiologics-in-pediatric-sports-medicine
#13
REVIEW
Christopher C Bray, Clark M Walker, David D Spence
Orthobiologics are biological substances that allow injured muscles, tendons, ligaments, and bone to heal more quickly. They are found naturally in the body; at higher concentrations they can aid in the healing process. These substances include autograft bone, allograft bone, demineralized bone matrix, bone morphogenic proteins, growth factors, stem cells, plasma-rich protein, and ceramic grafts. Their use in sports medicine has exploded in efforts to increase graft incorporation, stimulate healing, and get athletes back to sport with problems including anterior cruciate ligament ruptures, tendon ruptures, cartilage injuries, and fractures...
July 2017: Orthopedic Clinics of North America
https://www.readbyqxmd.com/read/28577781/orthobiologics-in-pediatric-orthopedics
#14
REVIEW
Robert F Murphy, James F Mooney
Orthobiologics are biologic devices or products used in orthopedic surgery to augment or enhance bone formation. The use of orthobiologics in pediatric orthopedics is less frequent than in other orthopedic subspecialties, mainly due to the naturally abundant healing potential and bone formation in children compared with adults. However, orthobiologics are used in certain situations in pediatric orthopedics, particularly in spine and foot surgery. Other uses have been reported in conjunction with specific procedures involving the tibia and pelvis...
July 2017: Orthopedic Clinics of North America
https://www.readbyqxmd.com/read/28577778/bone-substitute-materials-and-minimally-invasive-surgery-a-convergence-of-fracture-treatment-for-compromised-bone
#15
REVIEW
Thomas A Russell, Gerard Insley
This article focuses on the understanding of the biochemistry and surgical application of bone substitute materials (BSMs) and particularly the newer calcium phosphate materials that can form a structural orthobiologic matrix within the metaphyseal components of the periarticular bone. Six characteristics of BSMs are detailed that can be used as a guide for the proper selection and application of the optimal BSM type for periarticular fracture repair. These 6 characteristics of BSMs are divided into 2 pillars...
July 2017: Orthopedic Clinics of North America
https://www.readbyqxmd.com/read/28576198/current-orthobiologics-for-elective-arthrodesis-and-nonunions-of-the-foot-and-ankle
#16
REVIEW
George F Wallace
A fusion rate of 100% would be ideal. Despite adhering to sound surgical principles, complete compliance, and no adverse comorbidities, that 100% fusion rate goal is elusive. Orthobiologics are a special class of materials developed to enhance the fusion rates in foot and ankle arthrodesis sites. Whether orthobiologics are used for the first fusion or reserved for a nonunion is debatable, especially when considering cost.
July 2017: Clinics in Podiatric Medicine and Surgery
https://www.readbyqxmd.com/read/28282352/partial-pectoralis-tear-treated-with-orthobiologics-a-case-report
#17
Blake Boggess, Claude Moorman
No abstract text is available yet for this article.
March 2017: Current Sports Medicine Reports
https://www.readbyqxmd.com/read/28261732/mineral-binding-peptides-with-enhanced-binding-stability-in-serum
#18
Jae Sung Lee, Xiaohua Yu, Amy J Wagoner Johnson, William L Murphy
Although calcium phosphate (CaP) binding peptides are used to link orthobiologics to orthopedic biomaterials, their binding stability in physiological environment is still unknown. In this study, we investigate the binding capability of a series of CaP-binding peptides and their binding stability in serum solutions, which are selected to resemble physiological conditions. The findings in this study may be applicable for designing robust orthobiologic delivery systems.
March 6, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/27871424/orthobiologic-in-foot-ankle
#19
EDITORIAL
Sheldon S Lin
No abstract text is available yet for this article.
December 2016: Foot and Ankle Clinics
https://www.readbyqxmd.com/read/27871416/bone-marrow-aspirate-concentrate-for-bone-healing-in-foot-and-ankle-surgery
#20
REVIEW
Joshua S Harford, Travis J Dekker, Samuel B Adams
Autologous bone marrow aspirate concentrate (BMAC) has become a popular orthobiologic to augment bone healing. The potential benefit comes from osteoprogenitor cells and growth factors that can lead to new bone formation in the setting of foot and ankle arthrodesis procedures. BMAC has an excellent safety record and has demonstrated efficacy in animal models of bone healing. Although scant, the literature on the use of BMAC in foot and ankle surgery does demonstrate promise for this orthobiologic adjuvant.
December 2016: Foot and Ankle Clinics
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