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Orthobiologics

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https://www.readbyqxmd.com/read/28736619/the-role-of-orthobiologics-in-foot-and-ankle-surgery-allogenic-bone-grafts-and-bone-graft-substitutes
#1
REVIEW
James Wee, Gowreeson Thevendran
Orthobiologics are biological substances that are used therapeutically for their positive effects on healing skeletal and soft-tissue injuries. The array of orthobiological products currently available to the foot and ankle surgeon is wide, and includes bone allografts, bone substitutes, growth factors, and chondral scaffolds. Nonetheless, despite the surge in interest and usage of orthobiologics, there remains a relative paucity of research addressing their specific applications in foot and ankle surgery. In this review, we attempt to provide an overview of the literature on commonly available allogenic bone grafts and bone substitutes...
June 2017: EFORT open reviews
https://www.readbyqxmd.com/read/28577787/orthobiologics
#2
EDITORIAL
Frederick M Azar
No abstract text is available yet for this article.
July 2017: Orthopedic Clinics of North America
https://www.readbyqxmd.com/read/28577785/osseous-healing-in-foot-and-ankle-surgery-with-autograft-allograft-and-other-orthobiologics
#3
REVIEW
Jane C Yeoh, Brandon A Taylor
In the surgical treatment of foot and ankle abnormality, many problems require bone grafting for successful osseous union. Nonunion, reconstruction, and arthrodesis procedures pose specific challenges due to bony defects secondary to trauma, malunions, or previous surgery. Nonunion in foot and ankle arthrodesis is a significant risk and is well documented in recent literature. This article is a review of the recent literature regarding the use of bone graft and orthobiologics in foot and ankle surgery.
July 2017: Orthopedic Clinics of North America
https://www.readbyqxmd.com/read/28577784/autologous-blood-and-platelet-rich-plasma-injections-for-treatment-of-lateral-epicondylitis
#4
REVIEW
James H Calandruccio, Murphy M Steiner
Lateral epicondylitis (tennis elbow) is a frequent cause of elbow pain; most patients (80%-90%) are successfully treated with standard nonoperative methods (rest, nonsteroidal anti-inflammatory drugs, bracing, and physical therapy). Autologous blood injections and platelet-rich plasma injections are the two most frequently used orthobiologic techniques in the treatment of lateral epicondylitis. Studies of the effectiveness of autologous blood injections and platelet-rich plasma report varying outcomes, some citing significant clinical relief and others reporting no beneficial effect...
July 2017: Orthopedic Clinics of North America
https://www.readbyqxmd.com/read/28577783/biologic-approaches-to-problems-of-the-hand-and-wrist
#5
REVIEW
Murphy M Steiner, James H Calandruccio
Orthobiologics are not used as frequently in the hand and wrist as in other sites. The most frequently reported is the use of bone morphogenetic protein for the treatment of Kienböck disease. Animal studies have described improved tendon healing with the use of platelet-rich plasma (PRP), but no clinical studies have confirmed these results. PRP has been reported to produce improvements in the outcomes of distal radial fractures and osteoarthritis of the trapeziometacarpal in small numbers of patients. The use of orthobiologics in the hand and wrist are promising, but clinical trials are necessary to establish efficacy and safety...
July 2017: Orthopedic Clinics of North America
https://www.readbyqxmd.com/read/28577782/orthobiologics-in-pediatric-sports-medicine
#6
REVIEW
Christopher C Bray, Clark M Walker, David D Spence
Orthobiologics are biological substances that allow injured muscles, tendons, ligaments, and bone to heal more quickly. They are found naturally in the body; at higher concentrations they can aid in the healing process. These substances include autograft bone, allograft bone, demineralized bone matrix, bone morphogenic proteins, growth factors, stem cells, plasma-rich protein, and ceramic grafts. Their use in sports medicine has exploded in efforts to increase graft incorporation, stimulate healing, and get athletes back to sport with problems including anterior cruciate ligament ruptures, tendon ruptures, cartilage injuries, and fractures...
July 2017: Orthopedic Clinics of North America
https://www.readbyqxmd.com/read/28577781/orthobiologics-in-pediatric-orthopedics
#7
REVIEW
Robert F Murphy, James F Mooney
Orthobiologics are biologic devices or products used in orthopedic surgery to augment or enhance bone formation. The use of orthobiologics in pediatric orthopedics is less frequent than in other orthopedic subspecialties, mainly due to the naturally abundant healing potential and bone formation in children compared with adults. However, orthobiologics are used in certain situations in pediatric orthopedics, particularly in spine and foot surgery. Other uses have been reported in conjunction with specific procedures involving the tibia and pelvis...
July 2017: Orthopedic Clinics of North America
https://www.readbyqxmd.com/read/28577778/bone-substitute-materials-and-minimally-invasive-surgery-a-convergence-of-fracture-treatment-for-compromised-bone
#8
REVIEW
Thomas A Russell, Gerard Insley
This article focuses on the understanding of the biochemistry and surgical application of bone substitute materials (BSMs) and particularly the newer calcium phosphate materials that can form a structural orthobiologic matrix within the metaphyseal components of the periarticular bone. Six characteristics of BSMs are detailed that can be used as a guide for the proper selection and application of the optimal BSM type for periarticular fracture repair. These 6 characteristics of BSMs are divided into 2 pillars...
July 2017: Orthopedic Clinics of North America
https://www.readbyqxmd.com/read/28576198/current-orthobiologics-for-elective-arthrodesis-and-nonunions-of-the-foot-and-ankle
#9
REVIEW
George F Wallace
A fusion rate of 100% would be ideal. Despite adhering to sound surgical principles, complete compliance, and no adverse comorbidities, that 100% fusion rate goal is elusive. Orthobiologics are a special class of materials developed to enhance the fusion rates in foot and ankle arthrodesis sites. Whether orthobiologics are used for the first fusion or reserved for a nonunion is debatable, especially when considering cost.
July 2017: Clinics in Podiatric Medicine and Surgery
https://www.readbyqxmd.com/read/28282352/partial-pectoralis-tear-treated-with-orthobiologics-a-case-report
#10
Blake Boggess, Claude Moorman
No abstract text is available yet for this article.
March 2017: Current Sports Medicine Reports
https://www.readbyqxmd.com/read/28261732/mineral-binding-peptides-with-enhanced-binding-stability-in-serum
#11
Jae Sung Lee, Xiaohua Yu, Amy J Wagoner Johnson, William L Murphy
Although calcium phosphate (CaP) binding peptides are used to link orthobiologics to orthopedic biomaterials, their binding stability in physiological environment is still unknown. In this study, we investigate the binding capability of a series of CaP-binding peptides and their binding stability in serum solutions, which are selected to resemble physiological conditions. The findings in this study may be applicable for designing robust orthobiologic delivery systems.
March 6, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/27871424/orthobiologic-in-foot-ankle
#12
EDITORIAL
Sheldon S Lin
No abstract text is available yet for this article.
December 2016: Foot and Ankle Clinics
https://www.readbyqxmd.com/read/27871416/bone-marrow-aspirate-concentrate-for-bone-healing-in-foot-and-ankle-surgery
#13
REVIEW
Joshua S Harford, Travis J Dekker, Samuel B Adams
Autologous bone marrow aspirate concentrate (BMAC) has become a popular orthobiologic to augment bone healing. The potential benefit comes from osteoprogenitor cells and growth factors that can lead to new bone formation in the setting of foot and ankle arthrodesis procedures. BMAC has an excellent safety record and has demonstrated efficacy in animal models of bone healing. Although scant, the literature on the use of BMAC in foot and ankle surgery does demonstrate promise for this orthobiologic adjuvant.
December 2016: Foot and Ankle Clinics
https://www.readbyqxmd.com/read/27871414/orthobiologics-in-the-foot-and-ankle
#14
REVIEW
H Thomas Temple, Theodore I Malinin
Many allogeneic biologic materials, by themselves or in combination with cells or cell products, may be transformative in healing or regeneration of musculoskeletal bone and soft tissues. By reconfiguring the size, shape, and methods of tissue preparation to improve deliverability and storage, unique iterations of traditional tissue scaffolds have emerged. These new iterations, combined with new cell technologies, have shaped an exciting platform of regenerative products that are effective and provide a bridge to newer and better methods of providing care for orthopedic foot and ankle patients...
December 2016: Foot and Ankle Clinics
https://www.readbyqxmd.com/read/27871407/the-role-of-orthobiologics-in-fracture-healing-and-arthrodesis
#15
REVIEW
Sheldon S Lin, Michael G Yeranosian
Nonunion after tibial shaft fracture and hindfoot arthrodesis remains a major problem. Known risk factors include advanced age, immunosuppression, smoking, and diabetes. Several factors must be considered in the fracture healing process. This review evaluates the efficacy of orthobiologics in improving union rates after fracture or arthrodesis. Use of compounds have shown increased cellular proliferation experimentally. Percutaneous autologous bone marrow has shown increased cellular proliferation. Matrix supplementation has shown significant improvements in bone healing...
December 2016: Foot and Ankle Clinics
https://www.readbyqxmd.com/read/27870670/operating-room-supply-costs-in-orthopaedic-trauma-cost-containment-opportunities
#16
Taylor P Gurnea, Wesley P Frye, Peter L Althausen
In the current health care environment, cost containment is more important than ever. Most physicians currently are unaware of the cost of operating room supplies. A large amount of waste occurs secondary to lack of knowledge and absence of physician incentives for cost saving. Many of the decisions for supply use can be based on good scientific evidence, which supports specific cost saving measures. Careful attention to blood utilization and use of tranexamic acid has the potential to save millions in the hip fracture treatment and arthroplasty treatments...
December 2016: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/27788910/orthobiologics-and-knee-osteoarthritis-a-recent-literature-review-treatment-algorithm-and-pathophysiology-discussion
#17
REVIEW
David M Crane, Kristin S Oliver, Matthew C Bayes
This article reviews the current options in orthobiologics for the clinical treatment of knee osteoarthritis (OA). We describe a new model of knee OA that fills the gap in our understanding of it as a purely traumatic and/or inflammation-induced cartilage degenerative condition, to a current model of multinodal pathophysiology. We discuss graft choice and patient selection in the current state of understanding of the treatment of knee OA in a tissue engineering model with orthobiologics. We present a sample treatment algorithm and decision nest for deciding how to proceed with patient care...
November 2016: Physical Medicine and Rehabilitation Clinics of North America
https://www.readbyqxmd.com/read/27788909/regenerative-approaches-to-tendon-and-ligament-conditions
#18
REVIEW
Michael N Brown, Brian J Shiple, Michael Scarpone
Tendon and ligament injuries and degenerative conditions of these soft tissues have poor healing potential and healing is often incomplete. Biocellular and orthobiologic approaches including PRP and stem cell therapies are reviewed. A review of some of the regenerative medicine science and difficulties facing physicians exploring these methods is presented. A series of cases are reviewed demonstrating the application of these principles. Clinical experience with many of these biocellular interventions is outpacing validation in basic science studies...
November 2016: Physical Medicine and Rehabilitation Clinics of North America
https://www.readbyqxmd.com/read/27594334/editorial-commentary-focal-cartilage-defects-in-young-patients-indicate-autologous-chondrocyte-implantation-sooner-rather-than-later
#19
EDITORIAL
Bert R Mandelbaum
Articular cartilage lesions, whether acute or chronic, are among the most common and difficult-to-treat conditions of the knee in the adolescent and athletic population. The results from a study in this issue as well as some in the previous literature suggest that autologous chondrocyte implantation yields long-term improvement in function and symptoms and may be a viable treatment for young to adult athletes or patients with high physical demands and a long active lifespan. No intervention in the young symptomatic patient will yield inferior results because it appears that no treatment over time has deleterious effects...
September 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/27545050/a-randomized-clinical-trial-to-compare-the-effectiveness-of-rotator-cuff-repair-with-or-without-augmentation-using-porcine-small-intestine-submucosa-for-patients-with-moderate-to-large-rotator-cuff-tears-a-pilot-study
#20
RANDOMIZED CONTROLLED TRIAL
Dianne Bryant, Richard Holtby, Kevin Willits, Robert Litchfield, Darren Drosdowech, Alison Spouge, David White, Gordon Guyatt
BACKGROUND: The rate of rotator cuff repair failure is between 13% and 67%. Porcine small intestine submucosa (SIS) may be suitable to augment the repair. METHODS: There were 62 patients with moderate and large cuff tears randomized to repair alone (control) or augmentation with SIS (Restore Orthobiologic Implant; DePuy, Warsaw, IN, USA). Primary outcome was repair failure using magnetic resonance arthrography. Randomization occurred on completion of the repair...
October 2016: Journal of Shoulder and Elbow Surgery
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