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https://www.readbyqxmd.com/read/29330068/engineering-of-hydroxymandelate-synthases-and-the-aromatic-amino-pathway-enables-de-novo-biosynthesis-of-mandelic-and-4-hydroxymandelic-acid-with-saccharomyces-cerevisiae
#1
Mara Reifenrath, Eckhard Boles
Mandelic acid (MA) and 4-hydroxymandelic acid (HMA) are valuable specialty chemicals used as precursors for flavors as well as for cosmetic and pharmaceutical purposes. Today they are mainly synthesized chemically. Their synthesis through microbial fermentation would allow for environmentally sustainable production. In this work, we engineered the yeast Saccharomyces cerevisiae for high-level production of MA and HMA. Expressing the hydroxymandelate synthase from Amycolatopsis orientalis in a yeast wild type strain resulted in the production of 119mg/L HMA from glucose...
January 9, 2018: Metabolic Engineering
https://www.readbyqxmd.com/read/29321927/pulmonary-nocardiosis-in-a-patient-with-idiopathic-cd4-t-lymphocytopenia
#2
Vivek Jayaschandran, Sandra Gjorgova-Gjeorgjievski, Haamid Siddique
Idiopathic CD4 T-lymphocytopenia (ICL) is a rare immunodeficiency characterized by low CD4 T-lymphocyte count, which usually manifests with opportunistic infections. Nocardia as an opportunistic pathogen infecting patients with this condition has rarely been reported. Here, we describe the case of a 46-year-old male who presented with lung mass and respiratory and systemic symptoms and was eventually diagnosed with pulmonary nocardiosis. A workup for predisposing immunodeficiencies suggested a picture of ICL...
February 2018: Respirology Case Reports
https://www.readbyqxmd.com/read/29316554/skin-infections-due-to-bacteria-in-solid-organ-transplant-recipients-a-review
#3
Muneeb Ilyas, Nishita Maganty, Zachary Ginsberg, Amit Sharma
Though there is an abundance of information on cutaneous malignancies in transplant recipients, cutaneous infections in solid organ transplant recipients (SOTRs) are underrepresented in the dermatological literature. Our paper provides a comprehensive review of bacterial cutaneous infections within the solid organ transplant population. Cutaneous bacterial infections may lead to significant morbidity and even mortality in this immunosuppressed population. Thus, it is to the benefit of both dermatologists and other transplant care providers to better understand and recognize the features of cutaneous bacterial infections in SOTRs...
January 10, 2018: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29313162/correction-to-the-role-of-oral-co-trimoxazole-in-treating-nocardia-farcinica-keratitis-a-case-report
#4
Neharika Sharma, Stephen O'Hagan
This article [1] was unintentionally published twice in this journal, by the same authors.The following [1] should be considered the version of record and used for citation purposes: "Neharika Sharma and Stephen O'Hagan, The role of oral co-trimoxazole in treating Nocardia farcinica keratitis: a case report. Journal of Ophthalmic Inflammation and Infection (2016) 6:21 DOI 10.1186/s12348-016-0087-y".The duplicate [2]: "Neharika Sharma and Stephen O'Hagan, The role of oral co-trimoxazole in treating Nocardia farcinica keratitis: a case report...
January 8, 2018: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/29286958/chronic-nocardia-cyriacigeorgica-periprosthetic-knee-infection-successfully-treated-with-a-two-stage-revision-a-case-report
#5
Michael M Hadeed, J Ryan MacDonell, Ian J Dempsey, Christopher C Moore, James A Browne
CASE: We report the successful treatment of a Nocardia cyriacigeorgica periprosthetic joint infection (PJI) that occurred at the site of a total knee arthroplasty. To our knowledge, this organism has not previously been reported in the literature as a cause of PJI. Given the need for a prolonged duration of treatment for this organism (a minimum of 6 to 12 months), modifications to the standard 2-stage revision were made in consultation with infectious-disease specialists. CONCLUSION: PJI is a devastating complication that leads to substantial patient morbidity and utilization of health-care resources...
October 2017: JBJS Case Connector
https://www.readbyqxmd.com/read/29282439/diffuse-nocardial-spinal-subdural-empyema-diagnostic-dilemma-and-treatment-options
#6
Zaid Aljuboori, Mayur Sharma, Thomas Altstadt
Nocardiosis of the central nervous system and spine, in particular, is a rare infection with significant morbidity and mortality. Treatment is usually with antibiotics and surgical drainage or biopsy. The authors report a case of a 49-year-old man who presented with chronic lower back pain and paraplegia. He was found to have spinal subdural empyema caused by Nocardia farcinica. Laminectomy and sampling of the subdural collection were performed, and the patient was treated with triple intravenous antibiotics (linezolid, amikacin and ciprofloxacin)...
October 24, 2017: Curēus
https://www.readbyqxmd.com/read/29250670/an-overview-of-resistance-profiles-eskape-pathogens-from-2010-2015-in-a-tertiary-respiratory-center-in-romania
#7
Nicolae Ovidiu Peneş, Andrei Alexandru Muntean, Adriana Moisoiu, Mădălina Maria Muntean, Alexandru Chirca, Miron Alexandru Bogdan, Mircea Ioan Popa
Lower respiratory tract infections (LRTIs) is an umbrella term that covers a wide spectrum of diseases, comprising mild and severe, acute and chronic conditions. A wide spectrum of pathogens can be implicated, from viruses to pyogenic and atypical bacteria. A special place should be reserved for slow growing bacteria (Mycobacteria spp., Nocardia spp.) and parasites (i.e., hydatic cysts caused by Echinococcus granulosus). OBJECTIVE: The objective of this study is to observe, analyze and establish the drug susceptibility patterns for Enterococcus spp...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/29249789/-native-aortic-valve-endocarditis-caused-by-nocardia-asteroides-report-of-a-case
#8
Hiroshi Ishitoya, Eiki Sano, Rihito Higashi, Shingo Isshiki, Hideki Sasaki
Infection by Nocardia sp. is rare and usually affects immuno-depressed patients, such as those receiving chemotherapy and long-term steroid therapy. Cardiac involvement is uncommon and usually occurs as endocarditis. We present a case of native aortic valve endocarditis caused by Nocardia asteroides. Aortic valve translocation method was chosen because of extensive root infection with major disruption of the aortic annulus. Over 2 years after the surgery, there is no recurrence and no enlargement of the aortic annulus...
December 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/29233013/biotechnological-potential-for-degradation-of-isoprene-a-review
#9
Navnita Srivastva, Abhishek Singh, Yashpal Bhardwaj, Suresh Kumar Dubey
Isoprene, the ubiquitous, highly emitted non-methane volatile hydrocarbon, affects atmospheric chemistry and human health, and this makes its removal from the contaminated environment imperative. Physicochemical degradation of isoprene is inefficient and generates secondary pollutants. Therefore, biodegradation can be considered as the safer approach for its efficient abatement. This review summarizes efforts in this regard that led to tracking the diverse groups of isoprene degrading bacteria such as Methanotrophs, Xanthobacter, Nocardia, Alcaligenes, Rhodococcus, Actinobacteria, Alphaproteobacteria, Bacteriodetes, Pseudomonas, and Alcanivorax...
December 12, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/29225839/a-case-of-empyema-and-septic-arthritis-due-to-nocardia-farcinica
#10
Takashi Ishiguro, Hiroaki Yoshioka, Shoko Kawai, Shin-Ichi Katsumata, Tohru Gonoi, Noboru Takayanagi
Septic arthritis due to Nocardia sp. should be suspected when a patient with risk factors such as pneumoconiosis or diabetes mellitus develops joint symptoms, especially if the patient has had nocardiosis in other sites.
December 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29223135/simultaneous-anti-diabetic-and-anti-vascular-calcification-activity-of-nocardia-sp-utmc-751
#11
Fatemeh Salimi, Saeedeh Jafari-Nodooshan, Nazanin Zohourian, Sedighe Kolivand, Javad Hamedi
Alpha-amylase can act as a significant player in causing hyperglycemia, leading to protein glycation, which is the main complication in this condition, besides causing vascular calcification (VC), an important vascular failure caused due to thisIn order to find a natural source of the biocompounds with inhibitory effects on alpha-amylase,, fifteen fermentation broth extracts of actinobacteria (FBEA) (200 μg mL-1 ) have been screened. Finally, the effects of the most efficient FBE have been investigated on osteopontin (OPN, a VC marker) mRNA level in the vascular smooth muscle cells under the calcification conditions, and the chemical constituents of the most efficient FBE were analyzed using GC-MS analysis...
December 9, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/29219900/diagnostic-challenges-in-nocardia-keratitis
#12
Joséphine Behaegel, Sorcha Ní Dhubhghaill, Carina Koppen
OBJECTIVE: To present a case of diagnostic confusion in Nocardia keratitis in a contact lens wearer and to illustrate the characteristic clinical findings of this rare entity. METHODS: Case report of Nocardia keratitis that was mistaken for acanthamoeba, herpetic, and fungal keratitis in three tertiary corneal referral centers before the correct diagnosis of Nocardia infection was made. RESULTS: A 29-year-old contact lens wearer was referred to our hospital for a contact lens-associated bacterial keratitis, not improving under standard bacterial treatment...
December 5, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/29209902/dehydropropylpantothenamide-isolated-by-a-co-culture-of-nocardia-tenerifensis-ifm-10554t-in-the-presence-of-animal-cells
#13
Yasumasa Hara, Midori A Arai, Kanae Sakai, Naoki Ishikawa, Tohru Gonoi, Takashi Yaguchi, Masami Ishibashi
A new amide, named dehydropropylpantothenamide (1), was obtained by a co-culture of Nocardia tenerifensis IFM 10554T in the presence of the mouse macrophage-like cell line J774.1 in modified Czapek-Dox (mCD) medium. Compound 1 was synthesized from D-pantothenic acid calcium salt in 6 steps. The absolute configuration of natural compound 1 was determined by comparisons of the optical rotation and CD spectra of synthetic 1. In the present study, a new method for producing secondary metabolites was demonstrated using a "co-culture" in which the genus Nocardia was cultured in the presence of an animal cell line...
December 5, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/29198680/syndrome-of-inappropriate-antidiuretic-hormone-secretion-complicating-systemic-nocardiosis-in-a-renal-transplant-recipient-a-case-report
#14
C Melexopoulou, I D Pavlopoulou, A Zormpala, G L Daikos, J N Boletis, S Marinaki
BACKGROUND: Infection by Nocardia species is an uncommon cause of severe clinical syndromes, particularly in immunocompromised patients, and solid-organ transplantation is the most common underlying condition. The syndrome of inappropriate antidiuretic hormone secretion (SIADH) has been described thus far in lung and stem cell transplants with systemic nocardiosis. CASE REPORT: We report the first case of SIADH in a female elderly renal transplant recipient diagnosed with systemic nocardiosis 2 years after transplantation...
December 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29198568/nosp-regulated-nosiheptide-production-responds-to-both-peptidyl-and-small-molecule-ligands-derived-from-the-precursor-peptide
#15
Jingjing Li, Yue Li, Guoqing Niu, Heng Guo, Yanping Qiu, Zhi Lin, Wen Liu, Huarong Tan
Nosiheptide, an archetypal member of thiopeptide antibiotics, arises from post-translational modifications of a ribosomally synthesized precursor peptide that contains an N-terminal leader peptide (LP) sequence and a C-terminal core peptide (CP) sequence. Despite extensive efforts concerning the biosynthesis of thiopeptide antibiotics, the regulatory mechanisms in this process remain poorly understood. Using the nosiheptide-producing Streptomyces actuosus strain as a model system, we report here that NosP, a Streptomyces antibiotic regulatory protein, serves as the only cluster-situated regulator and activates the transcription of all structural genes, which are organized into two divergently transcribed operons in the nos cluster, by binding to their intergenic region...
November 17, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/29184344/nocardia-farcinica-brain-abscess-in-an-immunocompetent-old-patient-a-case-report-and-review-of-literature
#16
Dinesh Mohan Chaudhari, Pushpendra Nath Renjen, Raman Sardana, Hena Butta
By definition, a brain abscess is an intraparenchymal collection of pus. Nocardia shows to have a special tropism for the neural tissue. Solitary abscess represents the most common manifestation in the central nervous system, accounting for 1%-2% of all cerebral abscesses. In this report, we present a case of primary multiple brain abscesses due to Nocardia farcinica in an immune competent patient. Early diagnosis and surgical intervention is significant for the patient.
October 2017: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/29177692/dermatological-complications-after-solid-organ-transplantation
#17
REVIEW
Luigi Naldi, Anna Venturuzzo, Pietro Invernizzi
Organ transplant recipients (OTRs) are a population at high risk for cutaneous adverse events. Their early recognition and appropriate treatment is an important component of the clinical management of OTRs and should be optimally dealt with by dermatologists working in the context of a transplant dermatology clinic. Skin examination should be a standard procedure before performing organ transplantation to assess conditions which may be difficult to manage after the transplant procedure has been performed or which may represent a contraindication to transplantation, e...
November 25, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29166272/in-vitro-activity-of-some-essential-oils-alone-and-in-combination-against-the-fish-pathogen-nocardia-seriolae
#18
T F Ismail, T Yoshida
Microplate resazurin assay was applied to investigate the in vitro activity of four essential oils (EOs); cinnamon (Cinnamomum zeylanicum), thyme (Thymus vulgaris), lemongrass (Cymbopogon flexuosus) and tea tree (Melaleuca alternifolia) oils against 80 clinical isolates of the fish pathogen Nocardia seriolae. The checkerboard test was then used to determine the possible synergistic effect of EOs combination against reference type strains of fish nocardiosis. All tested EOs had antibacterial activity against N...
September 26, 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/29165305/abdominal-actinomycetoma-with-double-aetiology-due-to-nocardia-brasiliensis-and-actinomadura-madurae
#19
Alexandro Bonifaz, María Del Carmen Padilla, Denisse Vázquez-González, Marco A Hernández, Mariana Saldaña, Rigoberto Hernández-Castro, Andrés Tirado-Sánchez
No abstract text is available yet for this article.
November 22, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29146850/first-insight-into-the-genome-sequences-of-two-linezolid-resistant-nocardia-farcinica-strains-isolated-from-patients-with-cystic-fibrosis
#20
Sylvia Valdezate, Sara Monzón, Noelia Garrido, Angel Zaballos, María J Medina-Pascual, José M Azcona-Gutiérrez, Begoña Vilar, Isabel Cuesta
The draft genome sequences of two Nocardia farcinica strains isolated from two patients with cystic fibrosis (CF), resistant to trimethoprim/sulfamethoxazole and linezolid, are reported here. The estimated genome sizes were 5.8 Mb with a 70.63% G+C content. Transposases from Tn916 were detected, but not 23S rRNA mutation (G2576T) related to linezolid resistance.
November 16, 2017: Genome Announcements
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