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https://www.readbyqxmd.com/read/29780924/disseminated-nocardiosis-with-retinal-abscess-in-a-patient-treated-for-bullous-pemphigoid
#1
Sidharth Puri, Amir Hadayer, Andrea Breaux, Charles C Barr
Purpose: To report a case of disseminated Nocardiosis with retinal and intracranial lesions. Observations: A 49-year-old woman immunosuppressed because of treatment given for bullous pemphigoid presented with altered mental status and multiple intracranial lesions on imaging. The patient was found to have multiple retinal lesions in both eyes, including a subretinal abscess in the right eye. The patient underwent brain biopsy, confirming Nocardia farcinica histopathologically and in culture...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29780376/diversity-novelty-and-antimicrobial-activity-of-endophytic-actinobacteria-from-mangrove-plants-in-beilun-estuary-national-nature-reserve-of-guangxi-china
#2
Zhong-Ke Jiang, Li Tuo, Da-Lin Huang, Ilya A Osterman, Anton P Tyurin, Shao-Wei Liu, Dmitry A Lukyanov, Petr V Sergiev, Olga A Dontsova, Vladimir A Korshun, Fei-Na Li, Cheng-Hang Sun
Endophytic actinobacteria are one of the important pharmaceutical resources and well known for producing different types of bioactive substances. Nevertheless, detection of the novelty, diversity, and bioactivity on endophytic actinobacteria isolated from mangrove plants are scarce. In this study, five different mangrove plants, Avicennia marina, Aegiceras corniculatum, Kandelia obovota, Bruguiera gymnorrhiza , and Thespesia populnea , were collected from Beilun Estuary National Nature Reserve in Guangxi Zhuang Autonomous Region, China...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29773433/-cerebral-and-pulmonary-nocardiosis-to-nocardia-abscessus-in-an-immunocompetent-algerian-patient
#3
D Arrache, H Zait, V Rodriguez-Nava, E Bergeron, T Durand, M Yahiaoui, F Grenouillet, A Amrane, F Chaouche, A Baiod, K Madani, B Hamrioui
Nocardial brain abscess is often occurring in immunocompromised patients. It is uncommon in immunocompetent individuals. Here, the authors describe a case of cerebral and pulmonary nocardiosis mimicking a metastatic tumor in an apparently health 40-year-old Algerian male. The patient presented multiple brain abscess revealed by inaugural epileptic seizure. He was afebrile and presented with left hemiparesis. Staging imaging showed a nodular lung lesion in the apical segment of the right lower lobe. The patient underwent double craniotomy for resection of the lesion...
May 14, 2018: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29761888/idiopathic-sterile-pyogranuloma-in-three-domestic-cats
#4
A Giuliano, P Watson, L Owen, B Skelly, L Davison, J Dobson, F Costantino-Casas
Pyogranulomatous inflammation has been extensively described in cats, in particular in cases of feline infectious peritonitis and also associated with Mycobacteria, Actinomyces, Nocardia, Rhodococcus and fungal infections. Idiopathic sterile pyogranulomatous dermatitis has also been described. In this case series we describe the clinical presentation, histopathology and outcome of three cases of feline idiopathic sterile steroid-responsive pyogranuloma with different presentation and different locations of the lesion, but with the common feature of having a mass with no superficial skin involvement...
May 15, 2018: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29759798/an-acute-nocardia-infection-in-a-pediatric-hand
#5
Garrett Steinmetz, Kenton Panas, William Puffinbarger
Nocardia species are aerobic gram-positive filamentous organisms that may cause cutaneous or pulmonary disease in humans. Primary cutaneous nocardiosis may manifest as an acute superficial pyogenic infection that can mimic more common organisms such as Staphylococcus or Streptococcus. Acute pyogenic Nocardia infection of the pediatric hand is a rare manifestation of this condition. We present a 17-month-old boy who presented with an acute abscess formation on his left fourth and fifth digits that was found to be secondary to Nocardia brasiliensis...
May 11, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29746787/diagnostic-challenge-with-nocardia-subretinal-abscess-a-case-report-from-tuberculosis-endemic-region
#6
Parthopratim Dutta Majumder, Madhura Mukherjee, Lily Therese, Lingam Gopal, Jyotirmay Biswas
PURPOSE: To describe a case of Nocardia subretinal abscess, which posed a diagnostic challenge due to the presence of mycobacterial genome in sample obtained from fine needle aspiration biopsy (FNAB). METHODS: A retrospective chart review. RESULTS: A 25-year-old male presented with sudden, painless onset diminution of vision of left eye and found to have placoid patch of choroiditis just temporal to the macula in right eye and showed vitritis, subretinal abscess with exudative retinal detachment and vitreous hemorrhage in left eye...
May 10, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29746674/considerations-in-the-diagnosis-of-chronic-granulomatous-disease
#7
Joyce E Yu, Antoine E Azar, Hey J Chong, Artemio M Jongco, Benjamin T Prince
Chronic granulomatous disease (CGD) is a rare primary immunodeficiency that is caused by defects in the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex. The disease presents in most patients initially with infection, especially of the lymph nodes, lung, liver, bone, and skin. Patients with CGD are susceptible to a narrow spectrum of pathogens, and Staphylococcus aureus, Burkholderia cepacia complex, Serratia marcescens, Nocardia species, and Aspergillus species are the most common organisms implicated in North America...
May 9, 2018: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29740797/resolution-mechanism-and-characterization-of-an-ammonium-chloride-tolerant-high-thermostable-and-salt-tolerant-phenylalanine-dehydrogenase-from-bacillus-halodurans
#8
Wei Jiang, Ya-Li Wang, Bai-Shan Fang
As phenylalanine dehydrogenase (PheDH) plays an important role in the synthesis of chiral drug intermediates and detection of phenylketonuria, it is significant to obtain a PheDH with specific and high activity. Here, a PheDH gene, pdh, encoding a novel BhPheDH with 61.0% similarity to the known PheDH from Microbacterium sp., was obtained. The BhPheDH showed optimal activity at 60 °C and pH 7.0, and it showed better stability in hot environment (40-70 °C) than the PheDH from Nocardia sp. And its activity and thermostability could be significantly increased by sodium salt...
May 9, 2018: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/29740520/the-%C3%AE-bt1-large-serine-recombinase-catalyzes-dna-integration-at-pseudo-attb-sites-in-the-genus-nocardia
#9
Marion Herisse, Jessica L Porter, Romain Guerillot, Takehiro Tomita, Anders Goncalves Da Silva, Torsten Seemann, Benjamin P Howden, Timothy P Stinear, Sacha J Pidot
Plasmid vectors based on bacteriophage integrases are important tools in molecular microbiology for the introduction of foreign DNA, especially into bacterial species where other systems for genetic manipulation are limited. Site specific integrases catalyze recombination between phage and bacterial attachment sites ( attP and attB , respectively) and the best studied integrases in the actinomycetes are the serine integrases from the Streptomyces bacteriophages ΦC31 and ΦBT1. As this reaction is unidirectional and highly stable, vectors containing phage integrase systems have been used in a number of genetic engineering applications...
2018: PeerJ
https://www.readbyqxmd.com/read/29737456/disseminated-nocardiosis-caused-by-nocardia-elegans-a-case-report-and-review-of-the-literature
#10
Yi You, Wenchief Chen, Baiyu Zhong, Ziqiang Song, Xichuan Yang
BACKGROUND: Disseminated nocardiosis is a rare disease mostly occurring in immunocompromised patients. METHODS: We report a case of disseminated nocardiosis in a diabetic patient with both pulmonary and cutaneous involvement. Nocardia elegans was isolated and identified using the 16s ribosomal RNA gene sequence data. RESULTS: Clinical improvement was observed within 3 months after initiation of antimicrobial treatment with oral doxycycline, trimethoprim-sulfamethoxazole and intravenous penicillin, but the patient died 5 months later after arbitrary discontinuation of the treatment...
May 8, 2018: Infection
https://www.readbyqxmd.com/read/29714454/microbiological-and-clinical-data-analysis-of-32-patients-with-nocardia-infections-in-yantai
#11
Hong-Xia Yu, Ming Liu, Zeng-Hui Pu, Yan Liu, Mao-Mao Zhao
Background/aim: Nocardia is an opportunistic pathogen that mostly affects hosts with immune deficiencies. Recently, the widespread use of immunosuppressive agents and antitumor drugs has led to an increasing number of Nocardia infections being reported. However, it is difficult to confirm this diagnosis owing to the slow growth of the bacterium and its complex resultant clinical manifestations, potentially delaying treatment and increasing mortality. Thus, further knowledge on the clinical characteristics of Nocardia infection is required...
April 30, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29686152/pathogenic-nocardia-cyriacigeorgica-and-nocardia-nova-evolve-to-resist-trimethoprim-sulfamethoxazole-by-both-expected-and-unexpected-pathways
#12
H Mehta, J Weng, A Prater, R A L Elworth, X Han, Y Shamoo
Nocardia spp. are Gram positive opportunistic pathogens that affect largely immunocompromised patients leading to serious pulmonary or systemic infections. Combination therapy using the folate biosynthesis pathway inhibitors, trimethoprim and sulfamethoxazole (TMP-SMX) is commonly used as an antimicrobial therapy. Not surprisingly, as antibiotic therapies for nocardiosis can extend for many months, resistance to TMP-SMX has emerged. Using experimental evolution, we surveyed the genetic basis of adaptation to TMP-SMX across 8 strains of Nocardia nova and 2 strains of Nocardia cyriacigeorgica Employing both continuous experimental evolution to provide longitudinal information on the order of changes and characterization of resistant end-point isolates, we observe changes that are consistent with modification of two enzymes of the folate biosynthesis pathway: dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS/FolP) with the mutations often clustered near the active site of the enzymes...
April 23, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29674534/draft-genome-sequence-of-nocardia-suismassiliense-strain-s-137-csur-p4007
#13
Mustapha Fellag, Anthony Levasseur, Jérémy Delerce, Fadi Bittar, Jean-Lou Marié, Bernard Davoust, Michel Drancourt
" Nocardia suismassiliense " strain S-137 isolated from Sus scrofa feces exhibits a 9.4-Mb (67.1% GC content) draft genome sequence containing 8,658 protein-coding genes, 66 tRNAs, and 9 rRNAs. In silico DNA-DNA hybridization confirmed strain S-137 as representative of a new species, " Nocardia suismassiliense ," closely related to N. tenerifensis and N. brasiliensis .
April 19, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29669313/role-of-fna-and-special-stains-in-rapid-cytopathological-diagnosis-of-pulmonary-nocardiosis
#14
Ridhi Sood, Ruchita Tyagi, Pavneet Kaur Selhi, Gursheen Kaur, Harpreet Kaur, Akashdeep Singh
BACKGROUND: Nocardia, a gram-positive aerobic bacillus of the Actinomycetales family, is a significant opportunistic pathogen in immunocompromised individuals. Clinical and radiological features of pulmonary nocardiosis are nonspecific and can be misdiagnosed as tuberculosis, pneumocystis, staphylococcal or fungal infections, or as malignancy. Aspiration cytology with special stains is a quick and effective approach for accurate diagnosis. MATERIALS AND METHODS: We present 7 cases of pulmonary nocardiosis, admitted to the pathology department in a tertiary-care hospital in Punjab...
April 18, 2018: Acta Cytologica
https://www.readbyqxmd.com/read/29668123/nocardia-infections-in-the-transplanted-host
#15
M Hemmersbach-Miller, J E Stout, M H Woodworth, G M Cox, J L Saullo
BACKGROUND: Nocardia are uncommon pathogens that disproportionately afflict the immunocompromised host. Epidemiology and outcome data of Nocardia infections in transplant recipients are limited. METHODS: We performed a retrospective chart review of all patients at Duke University Hospital with a history of solid organ transplant (SOT) or hematopoietic cell transplant (HCT) and at least one positive culture for Nocardia between 1996-2013. Our aim was to describe the epidemiology and outcomes of Nocardia infections in the transplanted host...
April 18, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29668074/a-20-year-experience-with-nocardiosis-in-solid-organ-transplant-sot-recipients-in-the-southwestern-united-states-a-single-center-study
#16
Aneela Majeed, Norman Beatty, Ahmad Iftikhar, Adeela Mushtaq, Julia Fisher, Pryce Gaynor, Jeeyong C Kim, Jose Luis Marquez, Francisco E Mora, Anca Georgescu, Tirdad Zangeneh
BACKGROUND: Nocardiosis is a life-threatening opportunistic infection. Solid organ transplant (SOT) recipients are at higher risk (incidence 0.04% to 3.5%) of developing nocardiosis. Rate of nocardiosis in the Southwestern US may be high due to environmental factors. METHODS: We performed a retrospective review study on 54 SOT patients diagnosed with Nocardia between 1997 and 2016 at our center. To explore the association of various risk factors with both the development of disseminated disease and mortality, a series of Fisher's exact tests was used...
April 18, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29667664/identification-of-a-novel-aminopolycarboxylic-acid-siderophore-gene-cluster-encoding-the-biosynthesis-of-ethylenediaminesuccinic-acid-hydroxyarginine-edha
#17
Marius Spohn, Simone Edenhart, Mohammad Alanjary, Nadine Ziemert, Daniel Wibberg, Jörn Kalinowski, Timo H J Niedermeyer, Evi Stegmann, Wolfgang Wohlleben
The mechanism of siderophore-mediated iron supply enhances fitness and survivability of microorganisms under iron limited growth conditions. One class of naturally occurring ionophores is the small aminopolycarboxylic acids (APCAs). Although they are structurally related to the most famous anthropogenic chelating agent, ethylenediaminetetraacetate (EDTA), they have been largely neglected by the scientific community. Here, we demonstrate the detection of APCA gene clusters by a computational screening of a nucleotide database...
April 18, 2018: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/29666726/-nocardia-spp-pneumonia-in-a-solid-organ-recipient-role-of-linezolid
#18
George Mwandia, Hari Polenakovik
We describe a rare infection with Nocardia spp. ( N. pseudobrasiliensis species identification based on high-performance liquid chromatography analysis) in a 68-year-old renal transplant recipient. He presented with pneumonia complicated by hypoxic respiratory failure. He was allergic to sulphonamides. He was initially successfully treated with linezolid. However, he suffered severe sensory neuropathy after 4 months of therapy, necessitating linezolid cessation and completion of treatment with azithromycin...
2018: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/29665712/nocardia-rubra-cell-wall-skeleton-accelerates-cutaneous-wound-healing-by-enhancing-macrophage-activation-and-angiogenesis
#19
Yi Wang, Ying Hu, Ben Ma, Fei Wang, Sheng Liu, Jing Xu, Xu-Lin Chen, Xiong-Wen Lü
Objective This study was performed to investigate the effect of Nocardia rubra cell wall skeleton (N-CWS) on wound healing of full-thickness skin defects. Methods Two 2- × 2-cm full-thickness wounds, one on each side of the midline, were made on the back of 12 rats. One wound was covered with Vaseline gauze soaked in normal saline, whereas the other was covered with Vaseline gauze and N-CWS. Wound dressings were changed every other day from day 0 (wound creation) to day 11. Four of the 12 rats were killed on day 7, and biopsy samples were obtained for biochemical and histopathological analyses...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29665404/efficacy-of-recombinant-protein-vaccines-for-protection-against-nocardia-seriolae-infection-in-the-largemouth-bass-micropterus-salmoides
#20
Ping-Yueh Ho, Yao-Chung Chen, Shun Maekawa, Hsiang-Hui Hu, An-Wei Tsai, Yung-Fu Chang, Pei-Chi Wang, Shih-Chu Chen
A reverse vaccinology-based survey of potent antigens associated with fish nocardiosis was conducted using the largemouth bass, Micropterus salmoides, with an aim to develop subunit vaccines. The antigens selected from the virulent strain Nocardia seriolae 961113 include the gene products of NGL2579 (GAPDH), NGL5701 (MMP), NGL4377 (OCTase), NGL4486 (ABC transporter), NGL3372 (LLE), NGL3388 (GHf10), NGL6627 (Antigen-85), NGL6696 (Esterase), and NGL6936 (CBP). These antigens were heterologously expressed in E...
April 14, 2018: Fish & Shellfish Immunology
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