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https://www.readbyqxmd.com/read/28925928/subtenon-amikacin-injection-for-the-treatment-of-nocardia-asteroides-orbital-cellulitis-in-a-patient-with-a-history-of-scleral-buckling
#1
Zeynep Gursel Ozkurt, Hakan Demirci
PURPOSE: To evaluate the use of subtenon amikacin injection for the treatment of Nocardia asteroides orbital cellulitis in a patient with a history of scleral buckle surgery. METHODS: Case report. RESULTS: A 79-year-old diabetic woman presented with an 8-month history of diplopia, discharge, and swelling around her left eye. She had a scleral buckle surgery in this eye about 15 years ago. Examination of the left eye showed a visual acuity of 20/80, swollen and ptotic upper eyelid, chemotic conjunctiva, and limited extraocular motility...
October 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28923878/in-vitro-susceptibility-testing-of-tedizolid-against-isolates-of-nocardia
#2
Barbara A Brown-Elliott, Richard J Wallace
There is a paucity of efficacious antimicrobials (especially oral) against clinically relevant species of Nocardia To date, all species of Nocardia have been susceptible to linezolid, the first commercially available oxazolidinone. Tedizolid is a new oxazolidinone with previously reported improved in vitro and in vivo (intracellular) potency against multidrug resistant strains of Mycobacterium sp., and Nocardia brasiliensis Using the current Clinical and Laboratory Standards Institute recommended broth microdilution method, 101 isolates of Nocardia spp, including 29 N...
September 18, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28922286/nocardia-infections-in-solid-organ-and-hematopoietic-stem-cell-transplant-recipients
#3
Julien Coussement, David Lebeaux, Claire Rouzaud, Olivier Lortholary
PURPOSE OF REVIEW: Nocardia spp. is a gram-positive bacteria that may cause infections in humans. Nocardiosis has been described since the early years of transplantation. This review aims to provide an overview of present knowledge regarding posttransplant nocardiosis, with a focus on recent findings. RECENT FINDINGS: Nocardiosis is not rare among transplant recipients, especially after thoracic transplantation and/or in case of intense immunosuppressive regimen or use of tacrolimus...
September 15, 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/28919016/metarhizium-brunneum-an-enzootic-wireworm-disease-and-evidence-for-its-suppression-by-bacterial-symbionts
#4
Todd Kabaluk, Erica Li-Leger, Sean Nam
Wireworms (Coleoptera: Elateridae) are serious agricultural pests, with soil-dwelling larvae attacking subterranean tissues of crop plants and their fruit when in contact with the soil surface. Researchers collect wireworms for laboratory experiments to study their behaviour and test pest control agents but frequently lose them to Metarhizium Petch (Ascomycota: Hypocreales: Clavicipitaceae) infection. We found latent M. brunneum infection in 13-100% of live, asymptomatic Agriotes obscurus and A. lineatus wireworms acquired from agricultural fields and in wireworms maintained indoors, indicating its enzootic presence...
September 14, 2017: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/28918971/-pulmonary-nocardiosis-with-cerebral-abscesses-mimicking-metastatic-lung-cancer-three-cases-and-a-review-of-literature
#5
A Fourrier, M Kerjouan, C Piau, P A Lentz, C Ricordel, H Léna, R Corre, B Desrues, S Jouneau
Nocardiosis is an infectious disease with wide range of clinical features, which can eventually lead to death. The agent responsible belongs to the genus Nocardia that includes about fifty different species. Nocardiosis occurs mainly in immunocompromised hosts. We report here three cases of disseminated nocardiosis misdiagnosed initially as cerebral metastatic lung cancer. These patients, including two immunocompetent hosts, presented with both pulmonary and cerebral lesions. In all three patients, the diagnosis was based on magnetic resonance imaging with diffusion sequence, apparent diffusion coefficient reconstruction and neurosurgical cerebral biopsies...
September 14, 2017: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/28911184/subcellular-localization-and-function-study-of-a-secreted-phospholipase-c-from-nocardia-seriolae
#6
Liqun Xia, Haiying Liang, Liang Xu, Jianlin Chen, Michaël Bekaert, Honglian Zhang, Yishan Lu
Fish nocardiosis is a chronic systemic granulomatous disease, and Nocardia seriolae is the main pathogen that causes it. The pathogenesis and virulence factors of N. seriolae are not fully understood. A phospholipase C (PLC), which is likely to be a secreted protein targeting host cell mitochondria, was found by a bioinformatics analysis of the whole genome sequence of N. seriolae. In order to determine the subcellular localization and study the preliminary function of PLC from N. seriolae (NsPLC), in this study gene cloning, secreted protein identification, subcellular localization in host cells and apoptosis detection of NsPLC were carried out...
September 15, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28904677/-pulmonary-nocardiosis-in-immunocompetent-patients-about-2-cases
#7
Yasmina Rhofir, Rachida Zahraoui, Nabil Tiress, Hicham Naji-Amrani, Mouna Soualhi, Jamal Eddine Bourkadi
Nocardiosis is a rare but severe infection caused by bacteria of the genus nocardia, which belong to the order actinomycetales. If they can affect immunocompetent adult, nocardioses are pathologies affecting the individuals with weakened immune system. Pulmonary involvement is the most common manifestation, its correct management is based on diagnosis, which is often delayed due to non-specific symptoms and inconclusive specimens. We here report two cases of nocardiosis in immunocompetent patients. The first case concerns a 24-year old man with a history of smoking and alcoholism, hospitalized for chest pain and hemoptysis of low abundance evolving for two months, associated with the occurrence of dorsal subcutaneous fistulized abscess...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28888064/the-cytopathology-of-actinomyces-nocardia-and-their-mimickers
#8
REVIEW
Kelsey E McHugh, Charles D Sturgis, Gary W Procop, Daniel D Rhoads
Nocardia species and Actinomyces species are 2 of the most commonly diagnosed filamentous bacteria in routine cytopathology practice. These genera share many overlapping cytomorphologic features, including their thin, beaded, branching, Gram-positive, GMS-positive filamentous structures that fragment at their peripheries into bacillary- and coccoid-appearing forms. Features that help distinguish between these 2 microorganisms include the width of their filamentous structures, the angles at which they branch, and their ability or lack thereof to retain a modified acid-fast stain...
September 9, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28875906/nocardia-heshunensis-sp-nov-an-actinomycete-isolated-from-soil
#9
Jian-Rong Huang, Hong Ming, Yan-Yan Duan, Shuai Li, Ling-Yu Zhang, Wei-Li Ji, Zhuo-Li Zhao, Xiao-Lin Meng, Wen-Jun Li, Guo-Xing Nie
A novel Gram-stain-positive, aerobic, non-motile and acid-fast actinomycete strain, designated CFH S0067T, was isolated from a soil sample collected from Heshun old town in Tengchong, Yunnan province, in south-west PR China. The taxonomic position of strain CFH S0067T was studied in detail using a polyphasic approach. Phylogenetic analysis, based on 16S rRNA gene sequences, revealed that strain CFH S0067T belongs to the genus Nocardia and is closely related to Nocardia concava JCM 12351T (99.3 % similarity), forming a separated branch with this type strain...
September 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28870771/identification-and-antimicrobial-susceptibility-of-clinical-nocardia-species-in-a-tertiary-hospital
#10
Ming Wei, Peng Wang, Jiuxin Qu, Ran Li, Yongzhe Liu, Li Gu, Chunxia Yang
OBJECTIVES: The aim of this study was to determine the antibiotic susceptibility of 28 clinical isolates of Nocardia species isolated from Beijing Chao-Yang Hospital, for reducing the insufficiency of information on antimicrobial activities of Nocardia clinical isolates in specific species in China. METHODS: Molecular diagnosis of Nocardia species was performed using partial 16S rRNA and rpoB gene sequences. Antimicrobial susceptibility testing by broth microdilution was performed according to the Clinical and Laboratory Standards Institute recommendations...
September 1, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28839491/non-coding-rnas-are-differentially-expressed-by-nocardia-brasiliensis-in-vitro-and-in-experimental-actinomycetoma
#11
Josué S Cruz-Rabadán, Juan Miranda-Ríos, Guadalupe Espín-Ocampo, Luis J Méndez-Tovar, Héctor Rubén Maya-Pineda, Francisca Hernández-Hernández
INTRODUCTION: Nocardia spp. are common soil-inhabiting bacteria that frequently infect humans through traumatic injuries or inhalation routes and cause infections, such as actinomycetoma and nocardiosis, respectively. Nocardia brasiliensis is the main aetiological agent of actinomycetoma in various countries. Many bacterial non-coding RNAs are regulators of genes associated with virulence factors. OBJECTIVE: The aim of this work was to identify non-coding RNAs (ncRNAs) expressed during infection conditions and in free-living form (in vitro) in Nocardia brasiliensis...
2017: Open Microbiology Journal
https://www.readbyqxmd.com/read/28834821/therapeutic-femtosecond-laser-assisted-lamellar-keratectomy-for-multidrug-resistant-nocardia-keratitis
#12
Parth Shah, Dagny Zhu, William W Culbertson
PURPOSE: To describe the novel use of femtosecond laser technology for therapeutic resection of infectious foci in a case of multidrug-resistant Nocardia asteroides keratitis. METHODS: A 30-year-old man presented with a corneal infiltrate. Cultures were taken, and fortified vancomycin and tobramycin were initiated. After 3 negative cultures and minimal improvement on various broad-spectrum antibiotics, all topical medications were stopped and a final fourth corneal culture grew N...
August 22, 2017: Cornea
https://www.readbyqxmd.com/read/28820104/nocardia-cavernae-sp-nov-a-novel-actinobacterium-isolated-from-a-karst-cave-sample
#13
Qing-Qing Li, Ming-Xian Han, Bao-Zhu Fang, Jian-Yu Jiao, Lan Liu, Zi-Wen Yang, Wan-Qin Zhang, Da-Qiao Wei, Wen-Jun Li
A novel actinobacterial strain, designated YIM A1135T, was isolated from a soil sample collected from a karst cave in Xingyi county, Guizhou province, south-western China. The taxonomic position of the strain was investigated using a polyphasic approach. Cells of the strain were aerobic, Gram-stain-positive and partially acid-alcohol-fast. Strain YIM A1135T shared 98.3 % 16S rRNA gene sequence similarity with Nocardia jejuensis NBRC 103114T and 97.6 % with Nocardia alba YIM 30243T. DNA-DNA hybridization values between strain YIM A1135T and related type strains of the genus Nocardia were less than 70 %...
August 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28818275/electromagnetic-fields-may-act-via-calcineurin-inhibition-to-suppress-immunity-thereby-increasing-risk-for-opportunistic-infection-conceivable-mechanisms-of-action
#14
P R Doyon, O Johansson
While a good number of studies have demonstrated that modern, man-made ambient electromagnetic fields can have both stimulatory and inhibitory effect on immune system function, the precise mechanisms have yet to be completely elucidated. It is hypothesized here that, depending on the parameters, one of the means by which long-term electromagnetic field exposure has the potential to eventually lead to immunosuppression is via downstream inhibition of the enzyme calcineurin - a protein phosphatase, which activates the T-cells of the immune system and can be blocked by pharmaceutical agents...
September 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28811116/identification-of-nocardia-streptomyces-and-tsukamurella-using-maldi-tof-ms-with-the-bruker-biotyper
#15
Melanie L Yarbrough, William Lainhart, Carey-Ann D Burnham
Nocardia species are the most commonly isolated aerobic actinomycetes from human clinical specimens. Our objective was to assess the identification of clinically relevant actinomycetes using the Bruker Biotyper MALDI-TOF system, including comparison of extraction methods, Biotyper library versions, score cutoffs, and media. Banked Streptomyces (n=10), Tsukamurella (n=2), and Nocardia isolates (n=60) were cultured and extracted using three methods: mycobacterial extraction, ethanol formic acid extraction, or direct on-target extraction...
July 1, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28810311/-retrospective-analysis-of-13-cases-of-nocardiosis
#16
H Q Yang, H Z Shi, Z H Tong
Objective: To evaluate the clinical features, chest radiological manifestations, microbiological examination and treatments of nocardial disease. Methods: A retrospective study was conducted to analyze the data of patients with nocardial infection admitted to Beijing Chaoyang Hospital from January 2010 to January 2016. Results: The 13 patients, 6 males and 7 females, aged (51±17) years. Twelve cases were diagnosed with pulmonary nocardiosis, and 1 with disseminated nocardial infection. Most of these patients had complications: autoimmune diseases in 3 (2 with autoimmune hemolytic anemia and 1 with systemic lupus erythematosus), and bronchiectasis in 6 patients...
August 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28803018/short-communication-molecular-characteristics-antimicrobial-susceptibility-and-pathogenicity-of-clinical-nocardia-cyriacigeorgica-isolates-from-an-outbreak-of-bovine-mastitis
#17
Wei Chen, Yongxia Liu, Herman W Barkema, Jian Gao, Jeroen De Buck, John P Kastelic, Gang Liu, Tariq Ali, Muhammad Shahid, Bo Han
The occurrence of nocardial mastitis, mostly in the context of outbreaks, has been reported in many countries. However, there is a paucity of reports regarding detailed characterization of Nocardia cyriacigeorgica from bovine mastitis. Thus, herein we report characteristics, antimicrobial susceptibility patterns, molecular identification, and pathogenicity of N. cyriacigeorgica isolated from an outbreak of clinical mastitis in a dairy herd in northern China. A total of 182 (80.2%) lactating cows had clinical mastitis with severe inflammation and firmness of the udder, reduced milk production, and anorexia, with no apparent clinical response to common antibiotics...
August 9, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28795545/-brain-abcesses-associated-with-a-systemic-infection-by-nocardia-farcinica
#18
E Delvenne, F Farnir, J Guiot, J-B Giot, C Von Frenckell
The prevalence of nocardia infections is increasing because of both improved detection laboratory techniques and a higher number of immunosuppressed patients. We report the case of a patient with brain abcesses resulting from nocardia farcinica cerebral dissemination associated with lung infection, endocarditis and ocular lesions for which we suspected a similar origin. This case gives the opportunity to discuss the main issues of these infections and the current therapeutic guidelines.
July 2017: Revue Médicale de Liège
https://www.readbyqxmd.com/read/28794885/molecular-identification-of-nocardia-species-using-the-soda-gene-identificaci%C3%A3-n-molecular-de-especies-de-nocardia-utilizando-el-gen-soda
#19
K Sánchez-Herrera, H Sandoval, D Mouniee, N Ramírez-Durán, E Bergeron, P Boiron, N Sánchez-Saucedo, V Rodríguez-Nava
Currently for bacterial identification and classification the rrs gene encoding 16S rRNA is used as a reference method for the analysis of strains of the genus Nocardia. However, it does not have enough polymorphism to differentiate them at the species level. This fact makes it necessary to search for molecular targets that can provide better identification. The sodA gene (encoding the enzyme superoxide dismutase) has had good results in identifying species of other Actinomycetes. In this study the sodA gene is proposed for the identification and differentiation at the species level of the genus Nocardia...
September 2017: New Microbes and New Infections
https://www.readbyqxmd.com/read/28783142/intractable-cerebral-nocardia-mexicana-in-a-gvhd-patient-successfully-treated-with-linezolid
#20
A Majeed, A Mushtaq, T Zangeneh, R E Ramahi, S Batool, H Khan, A Latif, V Kapoor, F Anwer
No abstract text is available yet for this article.
August 7, 2017: Bone Marrow Transplantation
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