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https://www.readbyqxmd.com/read/28407752/detection-of-high-serum-levels-of-%C3%AE-d-glucan-in-disseminated-nocardial-infection-a-case-report
#1
Toyomitsu Sawai, Takumi Nakao, Shota Yamaguchi, Sumako Yoshioka, Nobuko Matsuo, Naofumi Suyama, Katsunori Yanagihara, Hiroshi Mukae
BACKGROUND: β-D-glucan (BDG) is a helpful diagnostic marker for many invasive fungal infections, but not for nocardiosis. Here, we reported the first case of nocardial infection with high serum level of BDG. CASE PRESENTATION: A 73-year-old man was hospitalized because of fever, headache, and appetite loss after 10 months of steroid and immunosuppressive therapy for cryptogenic organizing pneumonia. With a diagnosis of bacterial pneumonia, treatment with ampicillin/sulbactam was initiated...
April 13, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28399124/dual-color-fluorescence-in-situ-hybridization-fish-assays-for-detecting-mycobacterium-tuberculosis-and-mycobacterium-avium-complexes-and-related-pathogens-in-cultures
#2
Jyotsna Shah, Helena Weltman, Patricia Narciso, Christina Murphy, Akhila Poruri, Shrikala Baliga, Leesha Sharon, Mary York, Gail Cunningham, Steve Miller, Luz Caviedes, Robert Gilman, Edward Desmond, Ranjan Ramasamy
Two rapid dual color fluorescence in situ hybridization (FISH) assays were evaluated for detecting M. tuberculosis and related pathogens in cultures. The MN Genus-MTBC FISH assay uses an orange fluorescent probe specific for the Mycobacterium tuberculosis complex (MTBC) and a green fluorescent probe specific for the Mycobacterium and Nocardia genera (MN Genus) to detect and distinguish MTBC from other Mycobacteria and Nocardia. A complementary MTBC-MAC FISH assay uses green and orange fluorescent probes specific for the MTBC and M...
2017: PloS One
https://www.readbyqxmd.com/read/28397286/primary-cutaneous-nocardiosis-caused-by-nocardia-brasiliensis-following-a-wasp-sting
#3
L Chu, X Xu, Y Ran
We report a case of an 87-year-old woman who presented with painful erythema of her right forearm 10 days after she had been stung by a wasp on her right hand. The lesion had rapidly deteriorated during the week before presentation, and treatment with antibiotics and glucocorticoids did not improve the condition. After careful evaluation, we performed cultures from the lesion aspiration, and morphological and genetic analysis of bacteria cultures confirmed a bacterial infection with Nocardia brasiliensis. The patient recovered after 3 weeks...
April 10, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28387128/surgery-of-a-nocardia-lung-abscess-presenting-as-a-tension-pyopneumothorax
#4
Ryo Fujimoto, Mitsugu Omasa, Hiroyuki Ishikawa, Minoru Aoki
While some cases of nocardial pneumonia develop secondary empyema, tension pyopneumothorax is a very rare and lethal complication. A 74-year-old man who exhibited thrombocytopenia during steroid therapy for autoimmune hepatitis, presented to our department with a nocardial tension pyopneumothorax. He underwent a left lower lobectomy after chest drainage, and was discharged without any complication other than reoperation to remove a postoperative hematoma.
January 1, 2017: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/28381755/meningitis-and-ventriculitis-due-to-nocardia-araoensis-infection
#5
Fumio Yamamoto, Satoshi Yamashita, Hiroyuki Kawano, Tomio Tanigawa, Yosuke Mihara, Toru Gonoi, Yukio Ando
A 73-year-old man was admitted to our hospital with disturbance of consciousness, fever and headache. Cerebrospinal fluid (CSF) analysis revealed pleocytosis with neutrophil predominance, increased protein and low glucose. CSF and blood cultures yielded negative results. Antibiotics and antituberculous drugs were started for meningitis. An antimycotic was also added. The patient died from transtentorial hernia 99 days after admission. Autopsy revealed meningitis, ventriculitis and brain abscess, and Nocardia araoensis was detected in pus from the left lateral ventricle...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28381207/microbial-composition-of-spiny-ants-hymenoptera-formicidae-polyrhachis-across-their-geographic-range
#6
Manuela Oliveira Ramalho, Odair Correa Bueno, Corrie Saux Moreau
BACKGROUND: Symbiotic relationships between insects and bacteria are found across almost all insect orders, including Hymenoptera. However there are still many remaining questions about these associations including what factors drive host-associated bacterial composition. To better understand the evolutionary significance of this association in nature, further studies addressing a diversity of hosts across locations and evolutionary history are necessary. Ants of the genus Polyrhachis (spiny ants) are distributed across the Old World and exhibit generalist diets and habits...
April 5, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/28372487/nocardiosis-in-freshwater-reared-chinook-salmon-oncorhynchus-tshawytscha
#7
C L Brosnahan, S Humphrey, G Knowles, H J Ha, A Pande, J B Jones
CASE HISTORY: An investigation was conducted to identify the cause of mortalities in freshwater reared Chinook salmon (Oncorhynchus tshawytscha). Mortalities occurred in juvenile salmon, at a salmon rearing facility in the South Island of New Zealand. The affected fish were from a pen inside the facility with no surrounding pens or other year classes affected. CLINICAL FINDINGS: Clinically affected fish presented with skin lesions. The majority of skin lesions were unruptured, boil-like, raised circular masses up to 4 cm in diameter, particularly on the dorsolateral aspects and the flank...
April 3, 2017: New Zealand Veterinary Journal
https://www.readbyqxmd.com/read/28363588/effects-of-synbiotics-on-immunity-and-disease-resistance-of-narrow-clawed-crayfish-astacus-leptodactylus-leptodactylus-eschscholtz-1823
#8
Omid Safari, Marina Paolucci, Hamidreza Ahmadnia Motlagh
The aim of this study was to evaluate the effects of prebiotics (mannanoligosaccharide and xylooligosaccharide), probiotics (Enterococcus faecalis and Pediococcus acidilactici) and synbiotics for 126 days on the immune responses, hemolymph indices, antioxidant enzymes, and biological responses after a 48-hour Aeromonas hydrophila exposure of sub-adult crayfish (11.45 ± 1.87 g). Most antibacterial activities were observed in the shell mucus of crayfish fed a diet containing xylooligosaccharide + E. faecalis and mannanoligosaccharide + Pediococcus acidilactici against Nocardia brasilience and Vibrio harveyi (p < 0...
May 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28353613/severe-pneumonia-due-to-nocardia-otitidiscaviarum-identified-by-mass-spectroscopy-in-a-cotton-farmer-a-case-report-and-literature-review
#9
REVIEW
Chen Liu, Mei Feng, Jing Zhu, Ye Tao, Mei Kang, Lei Chen
RATIONALE: Nocardia species are aerobic saprophytic bacilli. Among Nocardia species, Nocardia otitidiscaviarum (N otitidiscaviarum) is rarely reported in pulmonary infection. PATIENT CONCERNS: We reported a case of N otitidiscaviarum pneumonia in a cotton farmer. DIAGNOSES: N otitidiscaviarum pneumonia was identified by mass spectroscopy. INTERVENTIONS: Combined treatments (amikacin, imipenem and trimethoprim-sulfamethoxazole) were administered after identification of N otitidiscaviarum...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28353001/de-novo-biosynthesis-of-trans-cinnamic-acid-derivatives-in-saccharomyces-cerevisiae
#10
Manuela Gottardi, Jan Dines Knudsen, Lydie Prado, Mislav Oreb, Paola Branduardi, Eckhard Boles
The production of natural aroma compounds is an expanding field within the branch of white biotechnology. Three aromatic compounds of interest are cinnamaldehyde, the typical cinnamon aroma that has applications in agriculture and medical sciences, as well as cinnamyl alcohol and hydrocinnamyl alcohol, which have applications in the cosmetic industry. Current production methods, which rely on extraction from plant materials or chemical synthesis, are associated with drawbacks regarding scalability, production time, and environmental impact...
March 29, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28352469/successful-treatment-of-pulmonary-nocardiosis-with-fluoroquinolone-in-bronchial-asthma-and-bronchiectasis
#11
Hironori Sadamatsu, Koichiro Takahashi, Hiroki Tashiro, Kazutoshi Komiya, Tomomi Nakamura, Naoko Sueoka-Aragane
A 72-year-old Japanese woman was admitted at Saga University Hospital for fever, malaise, and productive cough. Six years ago, she had been diagnosed with bronchial asthma and was treated with inhaled corticosteroids. Chest radiograph and computed tomography on admission showed infiltrates in the right middle lobe, a mass lesion in the left lower lobe, and bronchiectasis in both lower lobes. Sputum examination showed Gram-positive rods with phagocytosis by neutrophils. These bacilli were identified as Nocardia otitidiscaviarum by 16S ribosomal RNA sequencing...
May 2017: Respirology Case Reports
https://www.readbyqxmd.com/read/28348912/nocardia-brasiliensis-infection-complicating-cryptogenic-organizing-pneumonia
#12
Alison M Fernandes, Jason C Sluzevich, Isabel Mira-Avendano
Pulmonary nocardiosis is a severe and uncommon opportunistic infection caused by Nocardia species. We present a patient with cryptogenic organizing pneumonia who was receiving long-term immunosuppressive therapy, whose treatment course was complicated by cutaneous and pulmonary nocardiosis. Tissue cultures confirmed Nocardia brasiliensis. Nocardiosis should be a diagnostic consideration for patients treated with long-term immunosuppression who have worsening pulmonary symptoms and relapsing pustular skin lesions...
2017: Case Reports in Pulmonology
https://www.readbyqxmd.com/read/28348776/first-case-report-of-pulmonary-nocardiosis-caused-by-nocardia-mexicana
#13
Tomokazu Kuchibiro, Takeshi Ikeda, Hirotaka Nakanishi, Yukiko Morishita, Katsuyuki Houdai, Junko Ito, Tohru Gonoi
INTRODUCTION: Nocardia species usually cause opportunistic infections, and the frequency of these infections is increasing owing to the growing population of immunocompromised hosts. However, Nocardia species may sometimes cause an infection disease in immunocompetent hosts. Nocardia mexicana infections are the least common and are very rare. CASE PRESENTATION: Herein, we report the first case of a pulmonary infection with N. mexicana in a 61-year-old Japanese woman with a history of hyperlipidaemia and bronchiectasis and a 6-month history of non-productive hacking cough...
August 2016: JMM Case Reports
https://www.readbyqxmd.com/read/28342802/adjuvant-interferon-gamma-immunotherapy-in-a-patient-with-progressive-cerebral-nocardia-abscesses
#14
Jenneke Leentjens, Mark S Gresnigt, Frank L van de Veerdonk, Matthijs Kox, Bart Jan Kullberg, Peter Pickkers, Annemarie E Brouwer, Mihai G Netea
Despite advances in medical care, mortality due to cerebral Nocardia abscesses remains unacceptably high. The case of a typical immunocompromised patient, who deteriorated clinically despite optimal antimicrobial treatment, is reported here. Adjuvant immunotherapy with interferon-gamma resulted in partial restoration of the immune response and a corresponding clinical and radiographic recovery.
March 22, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28329650/increased-risk-of-opportunistic-infections-among-patients-with-moderate-to-severe-psoriasis-a-population-based-cohort-study-in-the-united-kingdom
#15
Junko Takeshita, Daniel B Shin, Alexis Ogdie, Joel M Gelfand
Infection is the second leading cause of death among psoriasis patients on phototherapy or systemic medications. The types of infections associated with psoriasis remain poorly understood. The aim of our study was to determine the risk of opportunistic infection (OI) among patients with psoriasis. We conducted a cohort study of patients with (N=199,700) and without (N=954,315) psoriasis in The Health Improvement Network electronic medical record database. Patients receiving phototherapy or systemic therapy were considered to have moderate-to-severe psoriasis (N=12,442)...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329348/outcome-and-treatment-of-nocardiosis-after-solid-organ-transplantation-new-insights-from-a-european-study
#16
David Lebeaux, Romain Freund, Christian van Delden, Hélène Guillot, Sierk D Marbus, Marie Matignon, Eric Van Wijngaerden, Benoit Douvry, Julien De Greef, Fanny Vuotto, Leïla Tricot, Mario Fernández-Ruiz, Jacques Dantal, Cédric Hirzel, Jean-Philippe Jais, Veronica Rodriguez-Nava, Frédérique Jacobs, Olivier Lortholary, Julien Coussement
Background: Solid organ transplant (SOT) recipients are at risk of nocardiosis, a rare opportunistic bacterial infection, but prognosis and outcome of these patients are poorly defined. Our objectives were to identify factors associated with one-year mortality after nocardiosis and describe the outcome of patients receiving short-course antibiotics (≤120 days). Methods: We analyzed data from a multicenter European case-control study that included 117 SOT recipients with nocardiosis diagnosed between 2000 and 2014...
February 4, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28315436/nocardia-rubra-cell-wall-skeleton-promotes-cd4-t-cell-activation-and-drives-th1-immune-response
#17
Guangchuan Wang, Jie Wu, Miao Miao, Heng Dou, Ning Nan, Mingsheng Shi, Guang Yu, Fengping Shan
Several lines of evidences have shown that Nocardia rubra cell wall skeleton (Nr-CWS) has immunoregulatory and anti-tumor activities. However, there is no information about the effect of Nr-CWS on CD4(+) T cells. The aim of this study was to explore the effect of Nr-CWS on the phenotype and function of CD4(+) T cells. Our results of in vitro experiments showed that Nr-CWS could significantly up-regulate the expression of CD69 and CD25 on CD4(+) T cells, promote the proliferation of CD4(+) T cells, increase the production of IFN-γ, TNF-α and IL-2 in the supernatants, but has no significant effect on the apoptosis and death of CD4(+) T cells...
March 15, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28299015/endogenous-nocardial-endophthalmitis-in-an-immunosuppressed-patient-a-serious-warning-of-an-underlying-life-threatening-and-blinding-disorder
#18
Hemant Trehan, Jaya Kaushik, Vaibhav Kumar Jain, Jitendra Kumar Singh Parihar, Abhijit Avasthi
PURPOSE: To report a case of bilateral endogenous nocardial endophthalmitis with central nervous system involvement in an immunocompromised individual with an extremely poor outcome. CASE REPORT: A 35-year-old man with a history of long-term, prescribed oral steroid use for membranoproliferative glomerulonephritis presented with profound bilateral vision loss. Patient's diagnosis of bilateral endogenous nocardial endophthalmitis was delayed. Nocardia was finally isolated from a brain biopsy after a repeat magnetic resonance imaging revealed a brain abscess...
January 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28290754/pulmonary-nocardia-beijingensis-infection-associated-with-the-use-of-alemtuzumab-in-a-patient-with-multiple-sclerosis
#19
Marwan Sheikh-Taha, Lourdes C Corman
Nocardia is a Gram-positive aerobic pathogen that usually affects immunocompromised patients. We report a case of pulmonary infection caused by a rare Nocardia species, Nocardia beijingensis, in a 50-year-old woman who had received alemtuzumab for the treatment of her multiple sclerosis. The invasive pulmonary infection was successfully treated with meropenem.
May 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28275374/cloning-expression-invasion-and-immunological-reactivity-of-a-mammalian-cell-entry-protein-encoded-by-the-mce1-operon-of-nocardia-farcinica
#20
Xingzhao Ji, Xiaoluo Tan, Xuexin Hou, Chenchen Si, Shuai Xu, Lu Tang, Xiuqin Yuan, Zhenjun Li
Bacterial mammalian cell entry (Mce) proteins have been implicated in pathogen invasion of mammalian host cells. The aim of this study was to examine the invasion-conferring ability of mce1E operon-encoded proteins, in vivo expression of Mce1E in cells from infected mice and rabbits, and Mce1E immunogenicity. Nocardia farcinica mce1E was cloned into pet30a(+) vectors, expressed in Escherichia coli, and purified. Invasion assays, transmission electron microscopy (TEM), immunoblots, and enzyme-linked immunosorbent assay (ELISA) detection of cytokines were conducted...
2017: Frontiers in Microbiology
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