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Juvenile hyaline cartilage

Cecilia Pascual-Garrido, Jiandong Hao, John Schrock, Omer Mei-Dan, Jorge Chahla
Cartilage lesions in the hip are of high prevalence. Most of these lesions are treated with microfracture. Microfracture has relatively good subjective outcomes for smaller lesions; however, it is limited by the ability to reproduce hyaline cartilage, especially in older patients. For larger chondral defects, we present a technique using juvenile allograft cartilage implantation implanted arthroscopically to treat cartilage lesions in the hip. The purpose of this technical note is to describe the arthroscopic technique for treating chondral lesions in the hip with allograft juvenile cartilage...
August 2016: Arthroscopy Techniques
Iwona Sudoł-Szopińska, Elżbieta Grochowska, Piotr Gietka, Mateusz Płaza, Grzegorz Pracoń, Fadhil Saied, Marta Walentowska-Janowicz
Juvenile idiopathic arthritis is the most common autoimmune systemic disease of the connective tissue affecting individuals in the developmental age. Radiography, which was described in the first part of this publication, is the standard modality in the assessment of this condition. Ultrasound and magnetic resonance imaging enable early detection of the disease which affects soft tissues, as well as bones. Ultrasound assessment involves: joint cavities, tendon sheaths and bursae for the presence of synovitis, intraand extraarticular fat tissue to visualize signs of inflammation, hyaline cartilage, cartilaginous epiphysis and subchondral bone to detect cysts and erosions, and ligaments, tendons and their entheses for signs of enthesopathies and tendinopathies...
September 2016: Journal of Ultrasonography
M H Jones, A M Williams
UNLABELLED: Osteochondritis Dissecans (OCD) is a condition for which the aetiology remains unknown. It affects subchondral bone and secondarily its overlying cartilage and is mostly found in the knee. It can occur in adults, but is generally identified when growth remains, when it is referred to as juvenile OCD. As the condition progresses, the affected subchondral bone separates from adjacent healthy bone, and can lead to demarcation and separation of its associated articular cartilage...
June 2016: Bone & Joint Journal
Dyane E Tower, Ryan W Wood, Michael D Vaardahl
Talocalcaneal joint middle facet coalition is the most common tarsal coalition, occurring in ≤2% of the population. Fewer than 50% of involved feet obtain lasting relief of symptoms after nonoperative treatment, and surgical intervention is commonly used to relieve symptoms, increase the range of motion, improve function, reconstruct concomitant pes planovalgus, and prevent future arthrosis from occurring at the surrounding joints. Several approaches to surgical intervention are available for patients with middle facet coalitions, ranging from resection to hindfoot arthrodesis...
November 2015: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
James M Cottom, Jared M Maker
Hyaline cartilage is avascular in nature, relying on surrounding synovial fluid for its nutrient supply. Lacking an inflammatory response, hyaline cartilage is unable to be repaired itself after injury. BMS technique allows reparative cartilage to be produced, taking the form of fibrocartilage. Fibrocartilage is weaker than hyaline cartilage. Various cartilage allograft materials are available for reparative techniques. The cartilage allograft materials discussed herein include fresh allograft transplantation, ACEM, and particulated juvenile articular cartilage...
January 2015: Clinics in Podiatric Medicine and Surgery
Stacey C Skaalure, Stanley Chu, Stephanie J Bryant
A new cartilage-specific degradable hydrogel based on photoclickable thiol-ene poly(ethylene glycol) (PEG) hydrogels is presented. The hydrogel crosslinks are composed of the peptide, CRDTEGE-ARGSVIDRC, derived from the aggrecanase-cleavable site in aggrecan. This new hydrogel is evaluated for use in cartilage tissue engineering by encapsulating bovine chondrocytes from different cell sources (skeletally immature (juvenile) and mature (adult) donors and adult cells stimulated with proinflammatory lipopolysaccharide (LPS)) and culturing for 12 weeks...
February 18, 2015: Advanced Healthcare Materials
Jack Farr, Samuel K Tabet, Ed Margerrison, Brian J Cole
BACKGROUND: Biological repair of cartilage lesions remains a significant clinical challenge because of the lack of natural regeneration and limited treatment options. HYPOTHESIS: Treatment of articular cartilage lesions in the knee with particulated juvenile articular cartilage (PJAC) will result in an improvement in patient symptoms of pain and function and magnetic resonance imaging (MRI) findings at 2 years compared with baseline. STUDY DESIGN: Case series; Level of evidence, 4...
June 2014: American Journal of Sports Medicine
Jack Farr, Brian J Cole, Seth Sherman, Vasili Karas
Cartilage Autograft Implantation System (CAIS; DePuy/Mitek, Raynham, MA) and DeNovo Natural Tissue (NT; ISTO, St. Louis, MO) are novel treatment options for focal articular cartilage defects in the knee. These methods involve the implantation of particulated articular cartilage from either autograft or juvenile allograft donor, respectively. In the laboratory and in animal models, both CAIS and DeNovo NT have demonstrated the ability of the transplanted cartilage cells to "escape" from the extracellular matrix, migrate, multiply, and form a new hyaline-like cartilage tissue matrix that integrates with the surrounding host tissue...
March 2012: Journal of Knee Surgery
Dustin L Kruse, Alan Ng, Matthew Paden, Paul A Stone
Osteochondral defects of the talus are a challenging subject facing foot and ankle surgeons. The available treatment options have relatively good subjective outcomes; however, they are limited by the ability to reproduce hyaline cartilage, the need for multiple surgeries, and high morbidity. We present a new technique using DeNovo NT(®) juvenile allograft cartilage implantation introduced into a talar lesion arthroscopically in a single procedure to repair a posteriomedial talar osteochondral defects in a healthy, active 30-year-old female...
March 2012: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
S P Krishnan, J A Skinner, R W J Carrington, A M Flanagan, T W R Briggs, G Bentley
We prospectively studied the clinical, arthroscopic and histological results of collagen-covered autologous chondrocyte implantation (ACI-C) in patients with symptomatic osteochondritis dissecans of the knee. The study included 37 patients who were evaluated at a mean follow-up of 4.08 years. Clinical results showed a mean improvement in the modified Cincinnati score from 46.1 to 68.4. Excellent and good clinical results were seen in 82.1% of those with juvenile-onset osteochondritis dissecans but in only 44...
February 2006: Journal of Bone and Joint Surgery. British Volume
C Krettek, M Jagodzinski, J Zeichen
The incidence of cartilage lesions is high. Due to pain and loss of function, long-term therapy is often necessary. Isolated, full-thickness articular cartilage lesions with a diameter of 4 cm2 are indications for chondrocyte transplantation. Many outcome studies report good long-term results. In recent years, the cultivation of chondrocytes has changed. Histologic investigations show hyalin-like cartilage after transplantation. Large cartilage lesions facing each other are a therapeutic dilemma in young patients...
May 2005: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
Jacqueline A Hughes, Jane V Cook, Mark A Churchill, Mary E Warren
BACKGROUND: Although MRI prognostic features for juvenile osteochondritis dissecans (JOCD) have been determined, the natural history of JOCD on serial MRI has not been fully documented. OBJECTIVES: To document the natural history of JOCD on serial MRI and to correlate this with arthroscopy and clinical outcome over a 5-year follow-up. MATERIALS AND METHODS: Twenty-one knees in 19 patients (15 boys, 4 girls; age range 5-15 years) with JOCD underwent MRI and clinical follow-up over 5 years...
June 2003: Pediatric Radiology
K Tominaga, S Hirashima, J Fukuda
The purpose of this study was to develop a model of osteoarthrosis of the temporomandibular joint in monkeys, which is remarkably similar in structure and function to that of humans. Nine juvenile monkeys, two as controls and seven as an experimental group, were used in this study. In the experimental group, the articular eminence on both sides was surgically made steeper. Two animals were killed at 1 week, four at 6 months, and one at 1 year postoperatively and the temporomandibular joints were examined macroscopically and microscopically...
June 2002: British Journal of Oral & Maxillofacial Surgery
Stefan Milz, Frank Regner, Reinhard Putz, Michael Benjamin
PURPOSE: To show that the molecular composition of the extracellular matrix of the trochlea and its associated tendon may explain the link between some cases of acquired Brown syndrome and rheumatoid arthritis. METHODS: One trochlea and its tendon from 11 dissecting-room cadavers were fixed in methanol, cryosectioned, and immunolabeled with a panel of monoclonal antibodies against types I, II, III, V, and VI collagens, chondroitin-4 and -6, keratan and dermatan sulfates, aggrecan, link protein, versican, and tenascin...
May 2002: Investigative Ophthalmology & Visual Science
D V Hendrix, P N Bochsler, B Saladino, M A Cawrse, J Thomas
A lesion was identified in the eye of a juvenile llama, and preliminary clinical findings included anterior uveitis and an exudative retinal detachment suggestive of infectious disease. However, histopathologic evaluation of the enucleated globe revealed an intraocular neoplasm composed of primitive neuroepithelium forming ribbons, cords, and rosettes, heteroplastic elements including spindle cells in a loose myxomatous matrix, and islands of well-differentiated hyaline cartilage. Immunohistochemically, neoplastic cells were positive for vimentin and neuron-specific enolase...
November 2000: Veterinary Pathology
Y Nakamura, K Noda, Y Kuwahara, L Minyeong, S Tanaka, K Kawasaki, K Kobayashi
Magnetic resonance images and the histology of spheno-occipital synchondrosis were examined in young monkeys in order to compare the magnetic resonance images with their histologic observations. In serial magnetics resonance images of posterior cranial base, the spheno-occipital synchondrosis showed a low signal zone with unclear boundaries, running through the posterior cranial base perpendicularly to the clivus. The zone was always interposed between nonsignal zones. These observations were the same as those in young juvenile human beings...
February 1999: American Journal of Orthodontics and Dentofacial Orthopedics
F Wacker, H König, D Felsenberg, K J Wolf
In a prospective study, the right knee of 21 symptom free juvenile footballers was examined by MRT (group I) and the results were compared with 12 juveniles of similar age but who did not take part in any special sporting activities (group II). A 1.5 Tesla Magnetome with an extremity coil was used. There were no abnormal changes in either group in the cruciate ligaments. The hyaline cartilage medially was about 10% thicker than laterally in both groups but in group I it was, on average, 24.8% thicker than in group II...
February 1994: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
D R Keene, J T Oxford, N P Morris
The collagen fibrils of hyaline cartilage vary in diameter depending on developmental stage and location within the tissue. In general, growth plates and fetal epiphyseal cartilages contain fibrils with diameters of less than approximately 25 nm, whereas the permanent cartilage of adult tissues contains fibrils of approximately 30-200 nm. The interstitial collagen fibrils of fetal cartilage are complex, having at least three collagen types as integral components. Type XI, a member of the fibrillar collagen class, has been proposed to limit fibril diameter...
October 1995: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
H Claassen, T Kirsch
Thyroid cartilages of various ages were investigated by immunofluorescence staining for localization of the fibrillar collagen types I and II in order to understand the tissue remodeling occurring during the mineralization and ossification of thyroid cartilage. In fetal and juvenile thyroid cartilages, type I collagen was restricted to the inner and outer perichondrium, while type II collagen was localized in the matrix of hyaline cartilage. However, in advanced ages, type I collagen was also localized in the pericellular and in the interterritorial matrix of intermediate and central chondrocytes of thyroid cartilage...
March 1994: Anatomy and Embryology
M B Cole
The honeycomb matrix and interlacunar network are described and compared in femoral head articular cartilage, proximal femoral physis, xiphoid, and tracheal cartilages from neonatal, juvenile, and adult rats. The honeycomb matrix is morphologically constant in all four sites of all age groups. The network is plentiful in cartilage of neonatal rats, reduced in juveniles, and rare in adults. In a given cartilage site, the network has a constant pattern and concentration gradient among rats of the same age. It is hypothesized that the network functions only during rapid cartilage growth and is not related to weight-bearing...
October 1982: Clinical Orthopaedics and related Research
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