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https://www.readbyqxmd.com/read/28102961/assessing-the-use-of-4dct-ventilation-in-pre-operative-surgical-lung-cancer-evaluation
#1
Yevgeniy Vinogradskiy, Matthew Jackson, Leah Schubert, Bernard Jones, Richard Castillo, Edward Castillo, Thomas Guerrero, John Mitchell, Chad Rusthoven, Moyed Miften, Brian Kavanagh
PURPOSE: A primary treatment option for lung cancer patients is surgical resection. Patients who have poor lung function prior to surgery are at increased risk of developing serious and life-threatening complications after surgical resection. Surgeons use nuclear medicine ventilation-perfusion (VQ) scans along with pulmonary function test (PFT) information to assess a patient's pre-surgical lung function. The nuclear medicine images and pre-surgery PFTs are used to calculate percent predicted postoperative (%PPO) PFT values by estimating the amount of functioning lung tissue that would be lost with surgical resection...
January 2017: Medical Physics
https://www.readbyqxmd.com/read/28102739/perceptions-of-mild-traumatic-brain-injury-in-adults-a-scoping-review
#2
Katie Mah, Andrea Hickling, Nick Reed
PURPOSE: The purpose of this article is to synthesise the scholarly literature related to perceptions of mild traumatic brain injury (mTBI) and health outcomes in an adult population. METHODS: A scoping review was undertaken. An electronic search of seven databases was conducted. Studies were included if (1) they related to perceptions of mild traumatic brain injury, (2) the population was adults with mild traumatic brain injury, and (3) health outcomes were reported...
January 19, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28102618/commentary-beyond-more-of-the-same-sustaining-the-benefits-of-preschool-education-reflections-on-bierman-et%C3%A2-al-2016
#3
Deborah A Phillips
Preschool education is now firmly linked to two aspirational purposes: as the first step on a trajectory of academic and life success for all children and as wise economic policy for the nation. Both purposes are grounded in an assumption that the early developmental boost children receive from preschool will produce lasting impacts. However, efforts to identify enduring impacts of contemporary preschool programs have produced mixed evidence, leading the field to acknowledge that we have yet to adequately understand the essential conditions and processes in early education classrooms that increase the odds that children will flourish in school and thrive in their adult lives...
February 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28102507/-44-sc-psma-617-for-radiotheragnostics-in-tandem-with-177-lu-psma-617-preclinical-investigations-in-comparison-with-68-ga-psma-11-and-68-ga-psma-617
#4
Christoph A Umbricht, Martina Benešová, Raffaella M Schmid, Andreas Türler, Roger Schibli, Nicholas P van der Meulen, Cristina Müller
BACKGROUND: The targeting of the prostate-specific membrane antigen (PSMA) is of particular interest for radiotheragnostic purposes of prostate cancer. Radiolabeled PSMA-617, a 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid (DOTA)-functionalized PSMA ligand, revealed favorable kinetics with high tumor uptake, enabling its successful application for PET imaging ((68)Ga) and radionuclide therapy ((177)Lu) in the clinics. In this study, PSMA-617 was labeled with cyclotron-produced (44)Sc (T 1/2 = 4...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28102163/does-mobility-of-the-elderly-with-hip-fractures-improve-at-one-year-following-surgery-a-5-year-prospective-survey
#5
Babak Pourabbas, Mohammad Jafar Emami, Amir Reza Vosoughi, Hamid Namazi
BACKGROUND: Hip fracture and its consequences are one of the major causes of morbidity and disability in the elderly. The purpose of this study was to collect epidemiologic data and assess the daily activities and walking ability of patients 3 months and 1 year following surgery because of a hip fracture. MATERIAL AND METHODS: We prospectively obtained data of all consecutive patients more than 50 years of age with any type of hip fracture from 2008 to 2013. After excluding pathologic fractures, hip fracture dislocations, non-surgically treated cases, and dead patients, functional status of the subjects at 3 months and 1 year after surgery was evaluated using a 10-degree scale of pain, modified Barthel index of daily activity, and independent walking ability...
August 30, 2016: Ortopedia, Traumatologia, Rehabilitacja
https://www.readbyqxmd.com/read/28101838/renal-consequences-of-preterm-birth
#6
REVIEW
Amelie Stritzke, Sumesh Thomas, Harish Amin, Christoph Fusch, Abhay Lodha
BACKGROUND: The developmental origin of health and disease concept identifies the brain, cardiovascular, liver, and kidney systems as targets of fetal adverse programming with adult consequences. As the limits of viability in premature infants have been pushed to lower gestational ages, the long-term impact of prematurity on kidneys still remains a significant burden during hospital stay and beyond. OBJECTIVES: The purpose of this study is to summarize available evidence, mechanisms, and short- and long-term renal consequences of prematurity and identify nephroprotective strategies and areas of uncertainty...
December 2017: Molecular and Cellular Pediatrics
https://www.readbyqxmd.com/read/28101732/the-analysis-of-knee-joint-loading-during-drop-landing-from-different-heights-and-under-different-instruction-sets-in-healthy-males
#7
Dmitry Verniba, Jason D Vescovi, David A Hood, William H Gage
BACKGROUND: Mechanical loading during exercise has been shown to promote tissue remodeling. Safe and accessible exercise may be beneficial to populations at risk of diminished bone and joint health. We examined the effect of drop height and instruction on knee loading during a drop-landing task and proposed a task that makes use of drop heights that may be appropriate for rehabilitation purposes and functional in daily life to examine transient knee joint loads. METHODS: Twenty males (22...
December 2017: Sports Medicine—Open
https://www.readbyqxmd.com/read/28101328/perceived-health-status-in-a-comparative-perspective-methodological-limitations-and-policy-implications-for-israel
#8
Baruch Levi
BACKGROUND: The perceived health status indicator included in the OECD Health Statistics suffers from severe methodological limitations related to data collection. Furthermore, this indicator is also included in the OECD's Better Life Index, thus distorting the total health score of some OECD countries, among them Israel. The purpose of this paper is to explore the erroneous use of OECD health data in Israel and to warn of its implications. METHODS: Analysis of data from the OECD Health Database, Better Life Index and the Israeli Central Bureau of Statistics, review of media reports and governmental documents concerning health measures, conversations and correspondence held with officials in the relevant organizations...
2017: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/28100149/the-meaning-of-ending-life-in-prison
#9
Alison Liebling
There are many ways that life can end in prison. This article takes suicides, murder, and the whole life sentence as three forms of unnatural death that illustrate important features of the prison experience and that take on a special meaning in this environment. These forms of death in custody challenge the "legitimate penological purposes of imprisonment." Reflections on the importance of hope and dignity in prison are informed by this account.
January 2017: Journal of Correctional Health Care
https://www.readbyqxmd.com/read/28100139/the-collision-of-inmate-and-patient
#10
Aline Chassagne, Aurélie Godard, Elodie Cretin, Lionel Pazart, Régis Aubry
Every year in France 100 inmates die in prison from illness, but their experiences with end of life (EOL) have not been investigated to date. The purpose of this article is to highlight the realities regarding inmates at the end of life, putting into perspective the viewpoints of the sick prisoners with those of the health and correctional professionals accompanying them. Based on qualitative research, the challenge is to identify potential barriers to palliative care for inmates in order to consider possible improvements...
January 2017: Journal of Correctional Health Care
https://www.readbyqxmd.com/read/28099630/the-brain-derived-neurotrophic-factor-bdnf-gene-val66met-polymorphism-affects-memory-performance-in-older-adults
#11
Lucas A de Azeredo, Tatiana De Nardi, Mateus L Levandowski, Saulo G Tractenberg, Julia Kommers-Molina, Andrea Wieck, Tatiana Q Irigaray, Irênio G da Silva, Rodrigo Grassi-Oliveira
Objective: Memory impairment is an important contributor to the reduction in quality of life experienced by older adults, and genetic risk factors seem to contribute to variance in age-related cognitive decline. Brain-derived neurotrophic factor (BDNF) is an important nerve growth factor linked with development and neural plasticity. The Val66Met polymorphism in the BDNF gene has been associated with impaired episodic memory in adults, but whether this functional variant plays a role in cognitive aging remains unclear...
January 12, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/28099273/making-the-most-of-hypomethylating-agents-in-myelodysplastic-syndrome
#12
Geetika Bhatt, William Blum
PURPOSE OF REVIEW: Hypomethylating agents (HMA) are the preferred therapy for patients with higher risk myelodysplastic syndromes (MDS) and an alternative therapeutic strategy for older patients with acute myeloid leukemia. These agents have improved both survival and quality of life, but results overall remain poor. The purpose of this review is to highlight recent developments in clinical research with HMA in MDS/acute myeloid leukemia over the last year. RECENT FINDINGS: Combination of HMA with B-cell lymphoma-2 inhibitors, hedgehog inhibitors, and a variety of other agents are underway, as are further studies with reformulated HMA that have more favorable pharmacokinetics (including oral bioavailability)...
January 17, 2017: Current Opinion in Hematology
https://www.readbyqxmd.com/read/28098581/timing-of-pavlik-harness-initiation-can-we-wait
#13
Jill E Larson, Anay R Patel, Brian Weatherford, Joseph A Janicki
BACKGROUND: Developmental dysplasia of the hip is effectively treated with a Pavlik harness (PH) within the first 6 months of life. Over 80% of unstable hips in the newborn period will naturally stabilize by 2 months of age. If there is no difference in the effectiveness of initiating PH treatment at 1 week compared with 4 weeks of age, waiting may allow the hips to naturally stabilize and avoid treatment. The purpose of this study is to evaluate whether the timing of PH implementation influences its effectiveness in the treatment of developmental dysplasia of the hip...
January 16, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28098500/exploring-black-college-females-perceptions-regarding-hiv-prevention-message-content
#14
Rasheeta Chandler-Coley, Henry Ross, Oluwatobi Ozoya, Celia Lescano, Timothy Flannigan
Media messages can facilitate the delivery of accurate information related to HIV and sexually transmitted infection. This study's purpose was to examine preexisting media campaigns from the iMPPACS study to assess age-, gender-, and culturally appropriate components identified by African American females who attend historically Black colleges/universities. In 3 separate focus group sessions, 31 Black female college students (M age = 20) viewed 4 vignettes and heard 3 audio-only clips, then ranked and commented on them based on perceived satisfaction with HIV prevention content and appropriateness of delivery...
January 18, 2017: Journal of Health Communication
https://www.readbyqxmd.com/read/28098336/preclinical-evaluation-of-intravenous-nax-810-2-a-novel-galr2-preferring-analog-for-anticonvulsant-efficacy-and-pharmacokinetics
#15
Cameron S Metcalf, Brian D Klein, Daniel R McDougle, Liuyin Zhang, Dan Kaufmann, Grzegorz Bulaj, H Steve White
OBJECTIVE: Potential clinical utility of galanin or peptidic analogs has been hindered by poor metabolic stability, lack of brain penetration, and hyperglycemia due to galanin receptor subtype 1 (GalR1) activation. NAX 810-2, a galanin receptor subtype 2 (GalR2)-preferring galanin analog, possesses 15-fold greater affinity for GalR2 over GalR1 and protects against seizures in the mouse 6 Hz, corneal kindling, and Frings audiogenic seizure models. The purpose of these studies was to further evaluate the preclinical efficacy and pharmacokinetics of NAX 810-2 in mice...
January 18, 2017: Epilepsia
https://www.readbyqxmd.com/read/28098085/experience-of-a-faculty-development-workshop-in-mentoring-at-an-indian-medical-college
#16
Jagdish R Varma, Anusha Prabhakaran, Suman Singh, Praveen Singh, Jaishree Ganjiwale, Himanshu Pandya
BACKGROUND: Our medical college is running a mentoring programme for undergraduate medical students since 2009. The academic leadership of the college identified the need to change the focus of the programme from mere problem- solving to professional and personal development of mentees. METHODS: A core group of faculty designed and implemented a workshop on mentoring for 28 mentors. The workshop included reflections on the participants' previous experiences about mentoring, discussion on perceptions of mentees about the existing mentoring programme, self-analysis of mentoring skills, overview of the Surrendering, Accepting, Gifting and Extending (SAGE) model and demonstration of effective mentoring skills using role plays and a film...
September 2016: National Medical Journal of India
https://www.readbyqxmd.com/read/28097941/telemedicine-support-shortens-length-of-stay-after-fast-track-hip-replacement
#17
Martin Svoldgaard Vesterby, Preben Ulrich Pedersen, Malene Laursen, Søren Mikkelsen, Jens Larsen, Kjeld Søballe, Lene Bastrup Jørgensen
Background and purpose - Telemedicine could allow patients to be discharged more quickly after surgery and contribute to improve fast-track procedures without compromising quality, patient safety, functionality, anxiety, or other patient-perceived parameters. We investigated whether using telemedicine support (TMS) would permit hospital discharge after 1 day without loss of self-assessed quality of life, loss of functionality, increased anxiety, increased rates of re-admission, or increased rates of complications after hip replacement...
February 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/28097920/extending-the-life-cycle-of-reverse-osmosis-membranes-a-review
#18
Eduardo Coutinho de Paula, Míriam Cristina Santos Amaral
The reverse osmosis (RO) technology for desalination and demineralization serves the global water crisis context, both technically and economically, and its market is growing. However, RO membranes have a limited life-cycle and are often disposed of in landfills. The impacts caused by the disposal of thousands of tonnes per annum of RO membranes have grown dramatically around the world. Waste prevention should have a high priority and take effect before the end-of-life phase of a product is reached. In this review, a summary is presented of the main advances in the performance of the RO technology and the membrane lifespan...
January 1, 2017: Waste Management & Research
https://www.readbyqxmd.com/read/28097267/incidence-and-risk-factors-of-recurrence-of-overactive-bladder-symptoms-after-discontinuation-of-successful-medical-treatment
#19
Aram Kim, Kyu-Sung Lee, Tae Beom Kim, Hyung Joon Kim, Eun Sang Yoo, Jong-Hyun Yun, Duk Yoon Kim, Suk Gun Jung, Jun Taik Lee, Jung Man Kim, Cheol Kyu Oh, Ju Hyun Shin, Seung Hyun Jeon, Seong Ho Lee, Chang Hee Han, Dong Hwan Lee, Hyuk Jin Cho, Myung-Soo Choo
PURPOSE: To identify incidence and risk factors of recurrence after discontinuation of successful antimuscarinic therapy in patients with overactive bladder (OAB). MATERIALS AND METHODS: This was a prospective, multicenter trial. Patients who had antimuscarinic agents for more than 12 weeks and showed successful response were enrolled. Successful response was defined as answering 'benefit' for patient perception of treatment benefit and answer lesser than 3 points in patient's perception of bladder condition (PPBC)...
January 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/28097178/antecedents-of-coping-with-the-disease-in-patients-with-multiple-sclerosis-a-qualitative-content-analysis
#20
Ali Dehghani, Nahid Dehghan Nayeri, Abbas Ebadi
BACKGROUND: Due to many physical and mental disorders that occur in multiple sclerosis patients, identifying the factors affecting coping based on the experiences of patients using qualitative study is essential to improve their quality of life. This study was conducted to explore the antecedents of coping with the disease in patients with multiple sclerosis. METHODS: This is a qualitative study conducted on 11 patients with multiple sclerosis in 2015 in Tehran, Iran...
January 2017: International Journal of Community Based Nursing and Midwifery
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