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Mohammad Asif Kiresur, Arunodaya Kunche, Anuradha Ananthaneni, Bhavana S Bagalad, Puneeth Horatti Kuberappa
Ameloblastic Carcinoma (AC) is uncommon malignant epithelial odontogenic tumour of jaw, with characteristic histologic features and behavior. Clinically, it has aggressive, infiltrative growth pattern with a distinct predilection for mandible. It exhibits histologic features of ameloblastoma and gets dedifferentiated overtime to culminate in carcinoma. Majority of the cases arise denovo (primary) and only few cases arise from a pre-existing ameloblastoma (secondary). Spindle-cell differentiation in ameloblastic carcinoma is rare; Salter described it as a separate entity "low-grade spindle cell ameloblastic carcinoma...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
Ariel B Ganz, Vanessa V Cohen, Camille C Swersky, Julie Stover, Gerardo A Vitiello, Jessica Lovesky, Jasmine C Chuang, Kelsey Shields, Vladislav G Fomin, Yusnier S Lopez, Sanjay Mohan, Anita Ganti, Bradley Carrier, Olga V Malysheva, Marie A Caudill
Single nucleotide polymorphisms (SNPs) in choline metabolizing genes are associated with disease risk and greater susceptibility to organ dysfunction under conditions of dietary choline restriction. However, the underlying metabolic signatures of these variants are not well characterized and it is unknown whether genotypic differences persist at recommended choline intakes. Thus, we sought to determine if common genetic risk factors alter choline dynamics in pregnant, lactating, and non-pregnant women consuming choline intakes meeting and exceeding current recommendations...
January 26, 2017: International Journal of Molecular Sciences
Michael Y Galperin, Xosé M Fernández-Suárez, Daniel J Rigden
This year's Database Issue of Nucleic Acids Research contains 152 papers that include descriptions of 54 new databases and update papers on 98 databases, of which 16 have not been previously featured in NAR As always, these databases cover a broad range of molecular biology subjects, including genome structure, gene expression and its regulation, proteins, protein domains, and protein-protein interactions. Following the recent trend, an increasing number of new and established databases deal with the issues of human health, from cancer-causing mutations to drugs and drug targets...
January 4, 2017: Nucleic Acids Research
Asha Kishore, Praveen James, Syam Krishnan, Lydia Yahia-Cherif, Sabine Meunier, Traian Popa
INTRODUCTION: Motor cortex plasticity is reported to be decreased in Parkinson's disease in studies which pooled patients in various stages of the disease. Whether the early decrease in plasticity is related to the motor signs or is linked to the future development of motor complications of treatment is unclear. The aim of the study was to test if motor cortex plasticity and its cerebellar modulation are impaired in treatment-naïve Parkinson's disease, are related to the motor signs of the disease and predict occurrence of motor complications of treatment...
February 2017: Parkinsonism & related Disorders
Michael R Gold, Reinoud Knops, Martin C Burke, Pier D Lambiase, Andrea M Russo, Maria Grazia Bongiorni, Jean-Claude Deharo, Johan Aasbo, Mikhael F El Chami, Michael Husby, Nathan Carter, Lucas Boersma
BACKGROUND: The UNTOUCHED study will assess the safety and efficacy of the subcutaneous implantable cardioverter defibrillator (S-ICD) in the most common cohort of patients receiving ICDs. The primary goal is to evaluate the inappropriate shock (IAS)-free rate in primary prevention patients with a reduced ejection fraction (EF) and compare with a historical control of transvenous ICD patients with similar programming. METHODS AND RESULTS: The UNTOUCHED study is a global, multicenter, prospective, nonrandomized study of patients undergoing de novo S-ICD implantation for primary prevention of sudden cardiac death with a left ventricular EF ≤35%...
January 2017: Pacing and Clinical Electrophysiology: PACE
Tychele N Turner, Qian Yi, Niklas Krumm, John Huddleston, Kendra Hoekzema, Holly A F Stessman, Anna-Lisa Doebley, Raphael A Bernier, Deborah A Nickerson, Evan E Eichler
Whole-exome and whole-genome sequencing have facilitated the large-scale discovery of de novo variants in human disease. To date, most de novo discovery through next-generation sequencing focused on congenital heart disease and neurodevelopmental disorders (NDDs). Currently, de novo variants are one of the most significant risk factors for NDDs with a substantial overlap of genes involved in more than one NDD. To facilitate better usage of published data, provide standardization of annotation, and improve accessibility, we created denovo-db (http://denovo-db...
January 4, 2017: Nucleic Acids Research
Dada Rima, Basant Kumar Shiv, Chawla Bhavna, Bisht Shilpa, Khan Saima
Background: Sperm DNA damage is underlying aetiology of poor implantation and pregnancy rates but also affects health of offspring and may also result in denovo mutations in germ line and post fertilization. This may result in complex diseases, polygenic disorders and childhood cancers. Childhood cancer like retinoblastoma (RB) is more prevalent in developing countries and the incidence of RB has increased more than three fold in India in the last decade. Recent studies have documented increased incidence of cancers in children born to fathers who consume alcohol in excess and tobacco or who were conceived by assisted conception...
January 9, 2016: Asian Pacific Journal of Cancer Prevention: APJCP
R Steckiewicz, D Górko, E B Świętoń, G Szparecki, P Stolarz
BACKGROUND: The technique of axillary vein (AV) or subclavian vein (SV) puncture has become an important alternative to cephalic vein (CV) cutdown as an approach allowing cardiac lead introduction into the venous system during cardiac implantable electronic device (CIED) implantation procedures. Irrespective of the technique used, the injury associated with lead insertion may induce a reflex venous spasm that can even cause total venous obstruction. In order to assess the incidence of AV spasm during AV puncture, we analysed a total of 735 (382 in females and 353 in males; mean age 75 ± 11 years) de novo CIED implantation procedures involving transvenous lead insertion conducted between January 2014 and December 2015...
2016: Folia Morphologica (Warsz)
David Wasylynko
OBJECTIVE: To present a case of chronic elbow pain as a result of a hidden underlying osteochondral defect. CLINICAL FEATURES: A 17-year old baseball player presented with chronic lateral elbow pain. Examination revealed swelling of the elbow with signs of possible ligament, muscle, and tendon injury. DIAGNOSIS AND TREATMENT: Although there was apparent soft-tissue injury, the elbow swelling created immediate suspicion of a more serious underlying condition...
September 2016: Journal of the Canadian Chiropractic Association
Joseph D Yesselman, Rhiju Das
Noncanonical RNA motifs help define the vast complexity of RNA structure and function, and in many cases, these loops and junctions are on the order of only ten nucleotides in size. Unfortunately, despite their small size, there is no reliable method to determine the ensemble of lowest energy structures of junctions and loops at atomic accuracy. This chapter outlines straightforward protocols using a webserver for Rosetta Fragment Assembly of RNA with Full Atom Refinement (FARFAR) ( http://rosie.rosettacommons...
2016: Methods in Molecular Biology
Muhammad Naeem, Mariyah Anwer, Muhammad Shamim Qureshi
OBJECTIVE: To find out the short term outcomes of effectiveness and safety of laparoscopic ventral rectopexy for rectal prolapse. METHODS: It was a descriptive case series study of 31 consecutive patients of rectal prolapse in Colorectal division of Ward 2, Department of General surgery, Jinnah Post Graduate Medical Center, Karachi, from November 2009 to November 2015. These patients were admitted through outpatient department with complains of something coming out of anus, constipation and per rectal bleeding...
July 2016: Pakistan Journal of Medical Sciences Quarterly
G F Calogiuri, S Al-Sowaidi, E Nettis, G Cortellini, L Macchia, A Vacca, N G Kounis
The role and importance of thienopyridines such as ticlopidine, clopidogrel, and prasugrel is well-established for several indications, ranging from prevention of acute coronary syndromes to percutaneous coronary interventions, where the dual antiplatelet therapy represents the gold standard to avoid denovo coronary stenosis. However, there is a significant cohort of patients with coronary artery disease who may manifest hypersensitivity reactions to thienopyridines. The examination of the various case reports from medical literature leads to identify mainly four clinical patterns of hypersensitivity to thienopyridines which involves more frequently cutaneous, hematologic, and articular tissues, therefore the kind and predominance of clinical symptoms may determine a different clinical approach to overcome or neutralize thienopyridines hypersensitivity...
November 1, 2016: International Journal of Cardiology
Lori Robbins, Karen Zaghiyan, Gil Melmed, Eric Vasiliauskas, Shahzad Ahmed, Dermot McGovern, Shervin Rabizadeh, Namita Singh, Carol Landers, Andrew Ippoliti, David Shih, Stephan Targan, Phillip Fleshner
BACKGROUND AND AIMS: A subset of patients who undergo ileal pouch-anal anastomosis [IPAA] for ulcerative colitis [UC] will later be diagnosed with denovo Crohn's disease [CD]. These patients have a higher risk of pouch failure. In this study we evaluated inflammatory bowel disease [IBD] serology in patients with denovo CD and examined the success of anti-tumour necrosis factor-alpha [anti-TNFα] therapy in preventing ileostomy in denovo CD patients who failed anti-TNFα therapy before IPAA...
January 2017: Journal of Crohn's & Colitis
Sean McMillan, Gregory T Lichtman, Christopher Betz
Current use of juvenile chondral allograft (DeNovo; Zimmer, Warsaw, IN) within the knee is an emerging treatment option for full-thickness, isolated chondral lesions. Its implantation traditionally involves a formal arthrotomy for exposure. Arthroscopic implantation minimizes the morbidity associated with this treatment option yet retains the promising functional results already established in the literature. We present a technique for all-arthroscopic implantation of juvenile chondral allograft (DeNovo) for a symptomatic, isolated chondral lesion within the trochlea of an adult knee...
April 2016: Arthroscopy Techniques
Sreejesh Sreedharanunni, Narender Kumar, Alka Khadwal
We report a rare CD5 positive B cell acute lymphoblastic leukemia (B-ALL) with a review of the clinopathological features and prognosis of previously reported cases in the literature. The aberrant expression of CD 5 antigen is uncommon in B-ALL; the morphological differential diagnosis includes blastic mantle cell lymphoma, denovo CD5(+) diffuse large B cell lymphoma and secondary diffuse large cell lymphoma/Richter's transformation. CD5(+) B cell ALL is commonly reported in younger patients (<18 years)...
June 2016: Indian Journal of Hematology & Blood Transfusion
Antonio D׳Amore, Joao S Soares, John A Stella, Will Zhang, Nicholas J Amoroso, John E Mayer, William R Wagner, Michael S Sacks
Mechanical conditioning of engineered tissue constructs is widely recognized as one of the most relevant methods to enhance tissue accretion and microstructure, leading to improved mechanical behaviors. The understanding of the underlying mechanisms remains rather limited, restricting the development of in silico models of these phenomena, and the translation of engineered tissues into clinical application. In the present study, we examined the role of large strip-biaxial strains (up to 50%) on ECM synthesis by vascular smooth muscle cells (VSMCs) micro-integrated into electrospun polyester urethane urea (PEUU) constructs over the course of 3 weeks...
September 2016: Journal of the Mechanical Behavior of Biomedical Materials
Aml Soliman, Asmaa Abdel Aal, Reham Afify, Noha Ibrahim
AIM: Aim was to detect Brain and Acute Leukemia, Cytoplasmic (BAALC) and ETS-related gene (ERG) expression in patients with acute myeloid leukemia (AML) as well as to study their biologic and prognostic impact on the disease outcome and survival. PATIENTS AND METHODS: The current study was carried out on 44 patients with denovo acute myeloid leukemia, as well as 44 age and sex matched controls. The quantitative real-time reverse transcription-polymerase chain reaction (RT-PCR) assay was performed for estimation of BAALC and ERG expression...
June 15, 2016: Open Access Macedonian Journal of Medical Sciences
Mohammad Yahya Vahidi Mehrjardi, Masoud Dehghan Tezerjani, Mahmoud Nori-Shadkam, Seyed Mehdi Kalantar, Mohammadreza Dehghani
The interpretation of supernumerary chromosome is important for genetic counseling and prognosis. Here, we used SNP array and conventional karyotyping method to identify a denovo marker chromosome originated from chromosome 22 and 11 in a newborn transferred to the Neonatal Intensive Care Unit of Shahid Sadoughi Hospital in 2015. Clinical abnormalities identified in the newborn were dysmorphic face, intrauterine growth retardation, atrial septal defect (ASD), the hypoplasia of corpus callosum and septum pellucidum...
March 2016: Iranian Journal of Public Health
Leia Hee, Andrew Terluk, Liza Thomas, Andrew Hopkins, Craig P Juergens, Sidney Lo, John K French, Christian J Mussap
OBJECTIVES: The aims of this study were to evaluate clinical outcomes following PCI using SeQuent Please paclitaxel-coated balloons (PCB) of ISR and denovo lesions (DNL), in all-comer patients at Liverpool Hospital, Sydney, Australia. BACKGROUND: There have been promising results for PCI using drug-coated balloons; however, long-term data for clinical outcomes are lacking. METHODS: Baseline patient demographics, PCI procedural details, and clinical outcomes were collected...
February 15, 2017: Catheterization and Cardiovascular Interventions
Tina Thomas, Tanwee Das De, Punita Sharma, Suman Lata, Priyanka Saraswat, Kailash C Pandey, Rajnikant Dixit
Hemocytes are tiny circulating blood cells of insects known to play multiple roles in physiological as well as cellular immune responses. However, the molecular nature of hemocytes in blood feeding insects, especially mosquitoes which transmit several deadly diseases such as malaria, dengue etc. is still limited. Therefore, to know the basic molecular composition of naïve mosquito hemocyte encoded proteins, we sequenced RNA-Seq library and analyzed a total of 13,105,858 Illumina sequencing reads in the mosquito Anopheles stephensi, an urban malarial vector in India...
July 10, 2016: Gene
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