Continuos

Potrebbe destare stupore richiamare l'attenzione dei cultori dell'Igiene e Sanità pubblica su una tra le opere più significative delle circa settanta che costituiscono il Corpus ippocratico - probabilmente assemblato nella biblioteca di Alessandria, all'inizio del III secolo a.C. - cioè sull' "Aria, Acqua, Luoghi", che identifica nell'ambiente, nelle condizioni metereologiche, nelle sostanze presenti nell'acqua da bere e in altri fattori molto concreti le possibili cause delle malattie, anziché attribuire loro un'origine soprannaturale...

Introduction: Neoadjuvant treatment leads in a reduction in positive lymph nodes and examined lymph nodes (ELN), which may affect assessment of lymph node staging and postoperative treatment. We aimed to compare the staging systems of lymph node ratio (LNR), the positive logarithm ratio of lymph nodes (LODDS), negative lymph nodes (NLN), and the 8th AJCC ypN stage for patients with gastric adenocarcinoma after neoadjuvant therapy. Materials and Methods: Data was collected from the Surveillance, Epidemiology, and End Results database and 1,551 patients with gastric adenocarcinoma who underwent neoadjuvant therapy and radical surgery were enrolled...

No abstract text is available yet for this article.

No abstract text is available yet for this article.

In this work, a methodology is presented for the determination of the respiration rate of a person under test (PUT), the detection of movements, as well as the elimination of the spurious effects produced by the movements of the PUT. The methodology is based on Empirical Modal Decomposition (EMD) applied to the phase signal obtained by means of a quadrature Doppler radar operating in S band. The EMD allows to automatically eliminate the continuos component (CC) which is present in the phase signal since one of the main characteristics of the modes generated by the EMD is that its mean is equal to zero...

The European regulation 536/2014, unapplied for several years due to the inoperability of the European Portal, represented an epochal turning point in the legislation concerning pharmacological clinical trials. Although, unlike the directive, it could be directly applied without national transpositions, in Italy this has not been possible and for three months now we have been witnessing a haemorrhage of guidelines/operational proposals/decrees that to date do not make us ready to fully operate according to the new rules...

OBJECTIVE: To analyze referrals from Primary Care (PC) consultation to Orthopaedic Surgery (OS) reference department. As a secondary objective, to establish two referral scenarios in order to determine the impact of variability on referral. METHODS: Cross-sectional observational study, analyzing referrals from PC to OS during the first half of the years 2018, 2019, and 2021. The number of referrals issued by each doctor and each PC Healthcare Center was examined, according to the classification of the different Basic Healthcare Zones (BHZ)...

Background: Sleep-disordered breathing (SDB) and other sleep disorders are very common conditions that can contribute to significant losses in quality of life, ability to work, and prognosis. Objectives: What were the new findings in sleep and respiratory medicine between November 2019 and October 2021 that significantly impact the care of patients with SDB? Methods: A systematic literature search was conducted between November 2019 and October 2021 and the most relevant articles were selected...

BACKGROUND: Dissection of the distal anterolateral aspect of the mesorectum remains a surgical challenge for low rectal cancer, posing a higher risk of residual mesorectum, which might lead to the increased incidence of local recurrence for patients with anterior wall involvement. OBJECTIVE: This study aimed to assess the effect of tumor location on outcome after laparoscopic low rectal cancer surgery. DESIGN: This is a single-center, retrospective study...

Process understanding and characterization forms the foundation, ensuring consistent and robust biologics manufacturing process. Using appropriate modeling tools and machine learning approaches, the process data can be monitored in real time to avoid manufacturing risks. In this article, we have outlined an approach toward implementation of chemometrics and machine learning tools (neural network analysis) to model and predict the behavior of a mixed-mode chromatography step for a biosimilar (Teriparatide) as a case study...

Cesarean section rates have increased globally in the last 30 years, representing more than 56% of total births in Brazil. Considering the impacts of elective cesarean sections in maternal and child health, this review aimed to present an option to reduce these rates. We used the SUPPORT tools to summarize the best evidence. We included systematic reviews published in English, Portuguese, or Spanish, which focused on non-clinical interventions. Continuous support during labor and birth was described in four systematic reviews as an option to reduce cesarean rates (down to -51%)...

Continuous non-invasive electroencephalographic monitoring is an essential technique for critical care patients as it shows directly and indirectly the patient’s brain activity and makes it possible to relate it with findings in the clinical status. It is highly sensitive, although its specificity is lower, so they can show alterations of the state of consciousness without clarifying the etiology. Continuous electroencephalographic recording in patients with altered levels of consciousness, seizures, and convulsive and non-convulsive status epilepticus has been increasing in recent years as real-time feedback of the cerebral function shows evolution changes and allows for the identification of electric and subclinical epileptic seizures that are highly important since they do not have clinical correlations...

OBJECTIVE:  To evaluate the differences between bladder emptying options (permanent catheterization and intermittent bladder emptying/spontaneous urination) regarding the effects on labor length, need of operative vaginal deliveries, and cesarean section rate. DATA SOURCES:  The search was conducted in MEDLINE, Scopus, Web of Science, and The Cochrane Central Register of Controlled Trials databases. SELECTION OF STUDIES:  The survey returned 964 studies...

OBJECTIVE: To evaluate the effectiveness and safety of sensor-augmented insulin pump therapy (SAP) in addition to a comprehensive diabetes program on glycated hemoglobin (HbA1c), severe hypoglycemia, ketoacidosis, and the hospital admission rate in patients with type 1 diabetes under real-world settings during a 2-year follow-up. METHODS: This was a retrospective real-life study comparing diabetes control before and after SAP therapy initiation. Patients ≥18 years old with type 1 diabetes were included...

Over the past 50 years there have been profound modifications in Italian and international societies. Even in our cardiology world, from the birth of the Italian Journal of Cardiology (GIC) to now, the methods of conduction of clinical research have undergone profound changes. The study that most significantly made Italian cardiology known globally was GISSI, which revolutionized the treatment of acute myocardial infarction, paving the way for substantial improvements in the outcome of patients with this clinical syndrome...

The new coronavirus (COVID-19) is having a major impact on mortality and survival in most countries of the world, with Mexico being one of the countries most heavily impacted by the pandemic. In this paper, we study the impact of COVID-19 deaths on period life expectancy at birth in Mexico by sex and state. We focus on the loss of life expectancy at different ages as a geographically comparable measure of the pandemic's impact on the population in 2020. Results show that males have been affected more than women since they have lost more years of life expectancy at birth due to COVID-19, and they have also experienced a high variation of life expectancy loss across states...

Diabetes Technology refers to the software or hardware that is designed to facilitate and improve the quality of life of the patient with diabetes Mellitus. A non-systematic literature search was carried out which included articles in English and Spanish about the use of continuous glucose monitoring (CGM) in pediatric patients with Type 1 diabetes Mellitus. This review summarizes the performance of the CGM, its accuracy, and classification. A chronological synthesis of the general evidence up to June 2020 was done including both adult and pediatric studies...

Introducción: Anteriormente se desarrolló una ley físico-matemática para la evaluación de registros electrocardiográficos continuos y Holters con la cual se dedujo la totalidad atractores cardíacos y se diferenció normalidad, estados patológicos y evolución entre estados. Método: Fueron tomadas 200 dinámicas cardiacas, 150 con diferentes tipos de patologías cardiacas y 50 normales, a las cuales se aplicó la ley exponencial, en 18 y 21 horas. Para ello, se simuló una secuencia de frecuencias cardiacas, con la cual fue construido el atractor caótico...

Background: Different severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia phenotypes were described that match with different lung compliance and level of oxygenation, thus requiring a personalized ventilator setting. The burden of so many patients and the lack of intensive care unit (ICU) beds often force physicians to choose non-invasive ventilation (NIV) as the first approach, even if no consent has still been reached to discriminate whether it is safer to choose straightforward intubation, paralysis, and protective ventilation...

No abstract text is available yet for this article.