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REVIEW
Emily R Smith, Erin Oakley, Gargi Wable Grandner, Gordon Rukundo, Fouzia Farooq, Kacey Ferguson, Sasha Baumann, Kristina Adams Waldorf, Yalda Afshar, Mia Ahlberg, Homa Ahmadzia, Victor Akelo, Grace Aldrovandi, Elisa Bevilacqua, Nabal Bracero, Justin S Brandt, Natalie Broutet, Jorge Carrillo, Jeanne Conry, Erich Cosmi, Fatima Crispi, Francesca Crovetto, Maria Del Mar Gil, Camille Delgado-López, Hema Divakar, Amanda J Driscoll, Guillaume Favre, Irene Fernandez Buhigas, Valerie Flaherman, Christopher Gale, Christine L Godwin, Sami Gottlieb, Eduard Gratacós, Siran He, Olivia Hernandez, Stephanie Jones, Sheetal Joshi, Erkan Kalafat, Sammy Khagayi, Marian Knight, Karen Kotloff, Antonio Lanzone, Valentina Laurita Longo, Kirsty Le Doare, Christoph Lees, Ethan Litman, Erica M Lokken, Shabir A Madhi, Laura A Magee, Raigam Jafet Martinez-Portilla, Torri D Metz, Emily S Miller, Deborah Money, Sakita Moungmaithong, Edward Mullins, Jean B Nachega, Marta C Nunes, Dickens Onyango, Alice Panchaud, Liona C Poon, Daniel Raiten, Lesley Regan, Daljit Sahota, Allie Sakowicz, Jose Sanin-Blair, Olof Stephansson, Marleen Temmerman, Anna Thorson, Soe Soe Thwin, Beth A Tippett Barr, Jorge E Tolosa, Niyazi Tug, Miguel Valencia-Prado, Silvia Visentin, Peter von Dadelszen, Clare Whitehead, Mollie Wood, Huixia Yang, Rebecca Zavala, James M Tielsch
OBJECTIVE: This sequential, prospective meta-analysis (sPMA) sought to identify risk factors among pregnant and postpartum women with COVID-19 for adverse outcomes related to: disease severity, maternal morbidities, neonatal mortality and morbidity, adverse birth outcomes. DATA SOURCES: We prospectively invited study investigators to join the sPMA via professional research networks beginning in March 2020. STUDY ELIGIBILITY CRITERIA: Eligible studies included those recruiting at least 25 consecutive cases of COVID-19 in pregnancy within a defined catchment area...
August 23, 2022: American Journal of Obstetrics and Gynecology
#22
JOURNAL ARTICLE
Emília Virgínia Noormahomed, Sérgio Noormahomed, Delfina Hlashwayo, Emília Martins, Mamudo Ismail, Stephen W Bickler, Jean Nachega, Manuel Mahoche, Kim E Barrett, Constance A Benson, Robert T Schooley
Background: The further development of research capacity in low- and middle-income countries is critical to the delivery of evidence-based healthcare, the design of sound health policy and effective resource allocation. Research capacity is also critical for the retention of highly skilled faculty and staff and for institutional internationalization. Objectives: We summarize the accomplishments, challenges and legacy of a five-year program to train biomedical researchers entitled "Enhanced Advanced Biomedical Research Training for Mozambique (EABRTM)"...
2022: Annals of Global Health
#23
EDITORIAL
E Petersen, A Zumla, D S Hui, L Blumberg, S R Valdoleiros, L Amao, F Ntoumi, D Asogun, L Simonsen, N Haider, T Traore, N Kapata, O Dar, J Nachega, A Abbara, A Al Balushi, R Kock, M Maeurer, S S Lee, D R Lucey, G Ippolito, Mpg Koopmans
No abstract text is available yet for this article.
July 1, 2022: International Journal of Infectious Diseases: IJID
#24
JOURNAL ARTICLE
Emily R Smith, Erin Oakley, Siran He, Rebecca Zavala, Kacey Ferguson, Lior Miller, Gargi Wable Grandner, Ibukun-Oluwa Omolade Abejirinde, Yalda Afshar, Homa Ahmadzia, Grace Aldrovandi, Victor Akelo, Beth A Tippett Barr, Elisa Bevilacqua, Justin S Brandt, Natalie Broutet, Irene Fernández Buhigas, Jorge Carrillo, Rebecca Clifton, Jeanne Conry, Erich Cosmi, Camille Delgado-López, Hema Divakar, Amanda J Driscoll, Guillaume Favre, Valerie Flaherman, Christopher Gale, Maria M Gil, Christine Godwin, Sami Gottlieb, Olivia Hernandez Bellolio, Edna Kara, Sammy Khagayi, Caron Rahn Kim, Marian Knight, Karen Kotloff, Antonio Lanzone, Kirsty Le Doare, Christoph Lees, Ethan Litman, Erica M Lokken, Valentina Laurita Longo, Laura A Magee, Raigam Jafet Martinez-Portilla, Elizabeth McClure, Torri D Metz, Deborah Money, Edward Mullins, Jean B Nachega, Alice Panchaud, Rebecca Playle, Liona C Poon, Daniel Raiten, Lesley Regan, Gordon Rukundo, Jose Sanin-Blair, Marleen Temmerman, Anna Thorson, Soe Thwin, Jorge E Tolosa, Julia Townson, Miguel Valencia-Prado, Silvia Visentin, Peter von Dadelszen, Kristina Adams Waldorf, Clare Whitehead, Huixia Yang, Kristian Thorlund, James M Tielsch
We urgently need answers to basic epidemiological questions regarding SARS-CoV-2 infection in pregnant and postpartum women and its effect on their newborns. While many national registries, health facilities, and research groups are collecting relevant data, we need a collaborative and methodologically rigorous approach to better combine these data and address knowledge gaps, especially those related to rare outcomes. We propose that using a sequential, prospective meta-analysis (PMA) is the best approach to generate data for policy- and practice-oriented guidelines...
2022: PloS One
#25
JOURNAL ARTICLE
Jean B Nachega, Rhoderick N Machekano, Lynne M Mofenson
No abstract text is available yet for this article.
May 9, 2022: JAMA Pediatrics
#26
JOURNAL ARTICLE
Pieter-Paul S Robbertse, Anton F Doubell, Jean B Nachega, Philip G Herbst
HIV-associated cardiomyopathy (HIVAC) is a poorly understood group of diseases with a poor prognosis once ventricular dysfunction is present. Cardiovascular magnetic resonance has revealed a previously unappreciated burden of asymptomatic myocardial abnormalities in people living with HIV, including abnormalities already present at the time of HIV diagnosis. These abnormalities include thickened, inflamed ventricles that bear resemblance to cases of symptomatic HIVAC that are reported on in this article. Our understanding and the significance of asymptomatic HIV-associated myocardial pathology will be explored as early disease on a continuum towards more advanced cardiomyopathy...
October 27, 2021: SA heart journal
#27
JOURNAL ARTICLE
Pascalina Chanda-Kapata, Francine Ntoumi, Nathan Kapata, Patrick Lungu, Luchenga Adam Mucheleng'anga, Jeremiah Chakaya, John Tembo, Cordelia Himwaze, Rashid Ansumana, Danny Asogun, Sayoki Mfinanga, Peter Nyasulu, Peter Mwaba, Dorothy Yeboah-Manu, Alimuddin Zumla, Jean B Nachega
BACKGROUND: The unprecedented and ongoing COVID-19 pandemic has exposed weaknesses in African countries' health systems. The impact of shifted focus on COVID-19 for the past 2 years on routine health services, especially those for the epidemics of Tuberculosis, HIV/AIDS and Malaria, have been dramatic in both quantity and quality. METHODS: In this article, we reflect on the COVID-19 related disruptions on the Tuberculosis, HIV/AIDS and Malaria routine health services across Africa...
March 24, 2022: International Journal of Infectious Diseases: IJID
#28
JOURNAL ARTICLE
Nadia A Sam-Agudu, Nana Kofi Quakyi, Refiloe Masekela, Alimuddin Zumla, Jean B Nachega
No abstract text is available yet for this article.
February 2022: BMJ Global Health
#29
JOURNAL ARTICLE
Ben Bepouka, Hippolyte Situakibanza, Modibo Sangare, Madone Mandina, Nadine Mayasi, Murielle Longokolo, Ossam Odio, Donatien Mangala, Fiston Isekusu, Jean Marie Kayembe, Jean Nachega, Marcel Mbula
Hypertension is a common comorbidity in COVID-19 patients. However, little data is available on mortality in COVID-19 patients with hypertension in sub-Saharan Africa (SSA). Herein, the authors conducted a systematic review of research articles published from January 1, 2020 to July 1, 2021. Our aim was to evaluate the magnitude of COVID-19 mortality in patients with hypertension in SSA. Following the PRISMA guidelines, two independent investigators conducted the literature review to collect relevant data. The authors used a random effect model to estimate the odds ratio, or hazard ratio, with a 95% confidence interval (CI)...
January 27, 2022: Journal of Clinical Hypertension
#30
JOURNAL ARTICLE
Jean B Nachega, Nadia A Sam-Agudu, Rhoderick N Machekano, Helena Rabie, Marieke M van der Zalm, Andrew Redfern, Angela Dramowski, Natasha O'Connell, Michel Tshiasuma Pipo, Marc B Tshilanda, Liliane Nsuli Byamungu, Refiloe Masekela, Prakash Mohan Jeena, Ashendri Pillay, Onesmus W Gachuno, John Kinuthia, Daniel Katuashi Ishoso, Emmanuella Amoako, Elizabeth Agyare, Evans K Agbeno, Charles Martyn-Dickens, Justice Sylverken, Anthony Enimil, Aishatu Mohammed Jibril, Asara M Abdullahi, Oma Amadi, Umar Mohammed Umar, Lovemore Nyasha Sigwadhi, Michel P Hermans, John Otshudiema Otokoye, Placide Mbala-Kingebeni, Jean-Jacques Muyembe-Tamfum, Alimuddin Zumla, Nelson K Sewankambo, Hellen Tukamuhebwa Aanyu, Philippa Musoke, Fatima Suleman, Prisca Adejumo, Emilia V Noormahomed, Richard J Deckelbaum, Mary Glenn Fowler, Léon Tshilolo, Gerald Smith, Edward J Mills, Lawal W Umar, Mark J Siedner, Mariana Kruger, Philip J Rosenthal, John W Mellors, Lynne M Mofenson
Importance: Little is known about COVID-19 outcomes among children and adolescents in sub-Saharan Africa, where preexisting comorbidities are prevalent. Objective: To assess the clinical outcomes and factors associated with outcomes among children and adolescents hospitalized with COVID-19 in 6 countries in sub-Saharan Africa. Design, Setting, and Participants: This cohort study was a retrospective record review of data from 25 hospitals in the Democratic Republic of the Congo, Ghana, Kenya, Nigeria, South Africa, and Uganda from March 1 to December 31, 2020, and included 469 hospitalized patients aged 0 to 19 years with SARS-CoV-2 infection...
January 19, 2022: JAMA Pediatrics
#31
EDITORIAL
Eskild Petersen, Francine Ntoumi, David S Hui, Aisha Abubakar, Laura D Kramer, Christina Obiero, Paul Anantharajah Tambyah, Lucille Blumberg, Richard Yapi, Seif Al-Abri, Tatiana de Castro Abreu Pinto, Dorothy Yeboah-Manu, Najmul Haider, Danny Asogun, Thirumalaisamy P Velavan, Nathan Kapata, Matthew Bates, Rashid Ansumana, Chiara Montaldo, Luchenga Mucheleng'anga, John Tembo, Peter Mwaba, Cordelia M Himwaze, Muzamil Mahdi Abdel Hamid, Sayoki Mfinanga, Leonard Mboera, Tajudeen Raj, Eleni Aklillu, Francisco Veas, Sarah Edwards, Pontiano Kaleebu, Timothy D McHugh, Jeremiah Chakaya, Thomas Nyirenda, Moses Bockarie, Peter S Nyasulu, Christian Wejse, Jean-Jacques Muyembe-Tamfum, Esam I Azhar, Markus Maeurer, Jean B Nachega, Richard Kock, Giuseppe Ippolito, Alimuddin Zumla
No abstract text is available yet for this article.
December 1, 2021: International Journal of Infectious Diseases: IJID
#32
JOURNAL ARTICLE
Quentin Eichbaum, Nadia A Sam-Agudu, Abigail Kazembe, Elsie Kiguli-Malwadde, Judy Khanyola, Judith N Wasserheit, Peter H Kilmarx, Jean B Nachega
Sustainable and equitable partnerships and collaborations between the Global North and Global South (as well as within the Global South) have been aspirations (if seldom achieved) of the "global health" endeavor over the past couple of decades. The COVID-19 pandemic led to global lockdowns that disrupted international travel and severely challenged these partnerships, providing a critical space for self-reflection on global health as a discipline. One major global north-south partnership is that between the African Forum for Research and Education in Health (AFREhealth) and the Consortium of Universities for Global Health (CUGH)...
2021: Annals of Global Health
#33
REVIEW
Etheldreda Nakimuli-Mpungu, Seggane Musisi, Colin M Smith, Megan Von Isenburg, Benedict Akimana, Ani Shakarishvili, Jean B Nachega, Edward J Mills, Dixon Chibanda, Marcelo Ribeiro, Anna V Williams, John A Joska
INTRODUCTION: Addressing the intersection between mental health and HIV is critical for the wellbeing of persons living with HIV (PLWH). This systematic review synthesized the literature on mental health interventions for PLWH in low- and middle-income countries (LMICs) to determine intervention components and explore their relationship with intervention effectiveness. METHODS: We included only controlled clinical trials of interventions aiming to improve the mental health of PLWH...
June 2021: Journal of the International AIDS Society
#34
REVIEW
Jay J H Park, Robin Mogg, Gerald E Smith, Etheldreda Nakimuli-Mpungu, Fyezah Jehan, Craig R Rayner, Jeanine Condo, Eric H Decloedt, Jean B Nachega, Gilmar Reis, Edward J Mills
COVID-19 has had negative repercussions on the entire global population. Despite there being a common goal that should have unified resources and efforts, there have been an overwhelmingly large number of clinical trials that have been registered that are of questionable methodological quality. As the final paper of this Series, we discuss how the medical research community has responded to COVID-19. We recognise the incredible pressure that this pandemic has put on researchers, regulators, and policy makers, all of whom were doing their best to move quickly but safely in a time of tremendous uncertainty...
May 2021: Lancet Global Health
#35
REVIEW
Jay J H Park, Rebecca F Grais, Monica Taljaard, Etheldreda Nakimuli-Mpungu, Fyezah Jehan, Jean B Nachega, Nathan Ford, Denis Xavier, Andre P Kengne, Per Ashorn, Maria Eugenia Socias, Zulfiqar A Bhutta, Edward J Mills
This paper shows the scale of global health research and the context in which we frame the subsequent papers in the Series. In this Series paper, we provide a historical perspective on clinical trial research by revisiting the 1948 streptomycin trial for pulmonary tuberculosis, which was the first documented randomised clinical trial in the English language, and we discuss its close connection with global health. We describe the current state of clinical trial research globally by providing an overview of clinical trials that have been registered in the WHO International Clinical Trial Registry since 2010...
May 2021: Lancet Global Health
#36
JOURNAL ARTICLE
Jean B Nachega, Markus Maeurer, Nadia A Sam-Agudu, Jeremiah Chakaya, Patrick D M Katoto, Alimuddin Zumla
After a century of controversies on its usefulness in protection against TB, underlying mechanisms of action, and benefits in various groups and geographical areas, the BCG vaccine is yet again a focus of global attention- this time due to the global COVID-19 pandemic caused by the novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Recent studies have shown that human CD4+ and CD8+ T-cells primed with a BCG-derived peptide developed high reactivity to its corresponding SARS-CoV-2-derived peptide...
December 2021: International Journal of Infectious Diseases: IJID
#37
JOURNAL ARTICLE
Jean B Nachega, Nadia A Sam-Agudu, John W Mellors, Alimuddin Zumla, Lynne M Mofenson
New England Journal of Medicine, Volume 385, Issue 3, Page 196-198, July 2021.
March 31, 2021: New England Journal of Medicine
#38
JOURNAL ARTICLE
Jean B Nachega, Nathan Kapata, Nadia A Sam-Agudu, Eric H Decloedt, Patrick D M C Katoto, Tumaini Nagu, Peter Mwaba, Dorothy Yeboah-Manu, Pascalina Chanda-Kapata, Francine Ntoumi, Elvin H Geng, Alimuddin Zumla
In this perspective, we discuss the impact of COVID-19 on tuberculosis (TB)/HIV health services and approaches to mitigating the growing burden of these three colliding epidemics in sub-Saharan Africa (SSA). SSA countries bear significantly high proportions of TB and HIV cases reported worldwide, compared to countries in the West. Whilst COVID-19 epidemiology appears to vary across Africa, most countries in this region have reported relatively lower-case counts compared to the West. Nevertheless, the COVID-19 pandemic has added an additional burden to already overstretched health systems in SSA, which, among other things, have been focused on the longstanding dual epidemics of TB and HIV...
March 20, 2021: International Journal of Infectious Diseases: IJID
#39
EDITORIAL
Alimuddin Zumla, Jeremiah Chakaya, Mishal Khan, Razia Fatima, Christian Wejse, Seif Al-Abri, Greg J Fox, Jean Nachega, Nathan Kapata, Michael Knipper, Miriam Orcutt, Lara Goscé, Ibrahim Abubakar, Tumaini Joseph Nagu, Ferdinand Mugusi, Alice Kizny Gordon, Sivakumar Shanmugam, Nathan Lloyd Bachmann, Connie Lam, Vitali Sintchenko, Frauke Rudolf, Farhana Amanullah, Richard Kock, Najmul Haider, Marc Lipman, Michael King, Markus Maeurer, Delia Goletti, Linda Petrone, Aashifa Yaqoob, Simon Tiberi, Lucica Ditiu, Suvanand Sahu, Ben Marais, Assiya Marat Issayeva, Eskild Petersen
No abstract text is available yet for this article.
December 2021: International Journal of Infectious Diseases: IJID
#40
JOURNAL ARTICLE
Jean B Nachega, Ethan D Borre, David W Dowdy, Pascalina Chanda-Kapata, Susan Cleary, Elvin H Geng
No abstract text is available yet for this article.
March 12, 2021: Lancet Global Health
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