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https://www.readbyqxmd.com/read/28630651/improving-antiretroviral-therapy-adherence-in-resource-limited-settings-at-scale-a-discussion-of-interventions-and-recommendations
#1
Jessica E Haberer, Lora Sabin, K Rivet Amico, Catherine Orrell, Omar Galárraga, Alexander C Tsai, Rachel C Vreeman, Ira Wilson, Nadia A Sam-Agudu, Terrence F Blaschke, Bernard Vrijens, Claude A Mellins, Robert H Remien, Sheri D Weiser, Elizabeth Lowenthal, Michael J Stirratt, Papa Salif Sow, Bruce Thomas, Nathan Ford, Edward Mills, Richard Lester, Jean B Nachega, Bosco Mwebesa Bwana, Fred Ssewamala, Lawrence Mbuagbaw, Paula Munderi, Elvin Geng, David R Bangsberg
Introduction: Successful population-level antiretroviral therapy (ART) adherence will be necessary to realize both the clinical and prevention benefits of antiretroviral scale-up and, ultimately, the end of AIDS. Although many people living with HIV are adhering well, others struggle and most are likely to experience challenges in adherence that may threaten virologic suppression at some point during lifelong therapy. Despite the importance of ART adherence, supportive interventions have generally not been implemented at scale...
2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28623554/-obesity-high-blood-pressure-hypercholesterolaemia-and-untreated-diabetes-in-hiv-infected-and-hiv-uninfected-adults-in-mbuji-mayi-democratic-republic-of-congo
#2
D Mukeba-Tshialala, J B Nachega, M Mutombo-Tshingwali, V Arendt, G Gilson, M Moutschen
Little is known about the major cardiovascular risk factors in HIV-infected as compared to the HIV-uninfected patients in the Democratic Republic of Congo (DR Congo). We determined the prevalence of hypertension, obesity (BMI ≥ 30 kg/m(2)), total cholesterol > 200 mg/dl, HDL-cholesterol ≤ 40 mg/dl, and glycemia > 126 mg/dl. We also calculated the average and/or median of total cholesterol, HDL-cholesterol, and glycemia among HIV-infected and HIV-uninfected patients. We conducted a cross-sectional study that enrolled 592 HIV-uninfected and 445 HIV-infected patients of whom 425 (95...
June 16, 2017: Bulletin de la Société de Pathologie Exotique
https://www.readbyqxmd.com/read/28407436/optimal-antiretroviral-therapy-adherence-as-evaluated-by-case-index-score-tool-is-associated-with-virological-suppression-in-hiv-infected-adults-in-dakar-senegal
#3
A K Byabene, L Fortes-Déguénonvo, K Niang, M N Manga, A N H Bulabula, J B Nachega, M Seydi
OBJECTIVE: To determine the prevalence and factors associated with optimal antiretroviral therapy (ART) adherence and virological failure (VLF) among HIV-infected adults enrolled in the national ART programme at the teaching hospital of Fann, Dakar, Senegal. METHODS: Cross-sectional study from 1 September 2013 to 30 January 2014. OUTCOMES: (1) optimal ART adherence by the Center for Adherence Support Evaluation (CASE) Index Score (>10) and (2) VLF (HIV RNA > 1000 copies/ml)...
April 13, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28364569/improving-antiretroviral-therapy-adherence-in-resource-limited-settings-at-scale-a-discussion-of-interventions-and-recommendations
#4
Jessica E Haberer, Lora Sabin, K Rivet Amico, Catherine Orrell, Omar Galárraga, Alexander C Tsai, Rachel C Vreeman, Ira Wilson, Nadia A Sam-Agudu, Terrence F Blaschke, Bernard Vrijens, Claude A Mellins, Robert H Remien, Sheri D Weiser, Elizabeth Lowenthal, Michael J Stirratt, Papa Salif Sow, Bruce Thomas, Nathan Ford, Edward Mills, Richard Lester, Jean B Nachega, Bosco Mwebesa Bwana, Fred Ssewamala, Lawrence Mbuagbaw, Paula Munderi, Elvin Geng, David R Bangsberg
INTRODUCTION: Successful population-level antiretroviral therapy (ART) adherence will be necessary to realize both the clinical and prevention benefits of antiretroviral scale-up and, ultimately, the end of AIDS. Although many people living with HIV are adhering well, others struggle and most are likely to experience challenges in adherence that may threaten virologic suppression at some point during lifelong therapy. Despite the importance of ART adherence, supportive interventions have generally not been implemented at scale...
March 22, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28317086/process-evaluation-of-a-randomized-controlled-trial-of-group-support-psychotherapy-for-depression-treatment-among-people-with-hiv-aids-in-northern-uganda
#5
Etheldreda Nakimuli-Mpungu, Kizito Wamala, James Okello, Sheila Ndyanabangi, Steve Kanters, Ramin Mojtabai, Jean B Nachega, Edward J Mills, Seggane Musisi
We describe the process evaluation for a randomized controlled trial that compared group support psychotherapy (GSP) with group HIV education for treatment of depression among people with HIV. Process data were obtained using mixed methods. Variables evaluated were indicators of feasibility and acceptability; causal mediating processes and contextual influences. GSP was feasible and acceptable. Potential mediating variables between GSP and reduction of depression were improved emotional and social support, better coping strategies, and pursuit of livelihoods...
March 19, 2017: Community Mental Health Journal
https://www.readbyqxmd.com/read/28291053/safety-of-tenofovir-disoproxil-fumarate-based-antiretroviral-therapy-regimens-in-pregnancy-for-hiv-infected-women-and-their-infants-a-systematic-review-and-meta-analysis
#6
Jean B Nachega, Olalekan A Uthman, Lynne M Mofenson, Jean R Anderson, Steve Kanters, Francoise Renaud, Nathan Ford, Shaffiq Essajee, Meg C Doherty, Edward J Mills
BACKGROUND: There are limited data on adverse effects of tenofovir disoproxil fumarate (TDF)-based antiretroviral therapy (ART) on pregnant women and their infants. METHODS: We conducted a systematic review of studies published between January 1980 and January 2017 that compared adverse outcomes in HIV-infected women receiving TDF- vs. non-TDF-based ART during pregnancy. The relative risk for associations was pooled using a fixed-effects model. RESULTS: Sixteen studies met study inclusion criteria...
March 10, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27928080/burden-of-diarrhea-in-the-eastern-mediterranean-region-1990-2013-findings-from-the-global-burden-of-disease-study-2013
#7
Ibrahim Khalil, Danny V Colombara, Mohammad Hossein Forouzanfar, Christopher Troeger, Farah Daoud, Maziar Moradi-Lakeh, Charbel El Bcheraoui, Puja C Rao, Ashkan Afshin, Raghid Charara, Kalkidan Hassen Abate, Mohammed Magdy Abd El Razek, Foad Abd-Allah, Remon Abu-Elyazeed, Aliasghar Ahmad Kiadaliri, Ali Shafqat Akanda, Nadia Akseer, Khurshid Alam, Deena Alasfoor, Raghib Ali, Mohammad A AlMazroa, Mahmoud A Alomari, Rajaa Mohammad Salem Al-Raddadi, Ubai Alsharif, Shirina Alsowaidi, Khalid A Altirkawi, Nelson Alvis-Guzman, Walid Ammar, Carl Abelardo T Antonio, Hamid Asayesh, Rana Jawad Asghar, Suleman Atique, Ashish Awasthi, Umar Bacha, Alaa Badawi, Aleksandra Barac, Neeraj Bedi, Tolesa Bekele, Isabela M Bensenor, Balem Demtsu Betsu, Zulfiqar Bhutta, Aref A Bin Abdulhak, Zahid A Butt, Hadi Danawi, Manisha Dubey, Aman Yesuf Endries, Imad D A Faghmous, Talha Farid, Maryam S Farvid, Farshad Farzadfar, Seyed-Mohammad Fereshtehnejad, Florian Fischer, Joseph Robert Anderson Fitchett, Katherine B Gibney, Ibrahim Abdelmageem Mohamed Ginawi, Melkamu Dedefo Gishu, Harish Chander Gugnani, Rahul Gupta, Gessessew Bugssa Hailu, Randah Ribhi Hamadeh, Samer Hamidi, Hilda L Harb, Mohammad T Hedayati, Mohamed Hsairi, Abdullatif Husseini, Nader Jahanmehr, Mehdi Javanbakht, Tariku Jibat, Jost B Jonas, Amir Kasaeian, Yousef Saleh Khader, Abdur Rahman Khan, Ejaz Ahmad Khan, Gulfaraz Khan, Tawfik Ahmed Muthafer Khoja, Yohannes Kinfu, Niranjan Kissoon, Ai Koyanagi, Aparna Lal, Asma Abdul Abdul Latif, Raimundas Lunevicius, Hassan Magdy Abd El Razek, Azeem Majeed, Reza Malekzadeh, Alem Mehari, Alemayehu B Mekonnen, Yohannes Adama Melaku, Ziad A Memish, Walter Mendoza, Awoke Misganaw, Layla Abdalla Ibrahim Mohamed, Jean B Nachega, Quyen Le Nguyen, Muhammad Imran Nisar, Emmanuel Kwame Peprah, James A Platts-Mills, Farshad Pourmalek, Mostafa Qorbani, Anwar Rafay, Vafa Rahimi-Movaghar, Sajjad Ur Rahman, Rajesh Kumar Rai, Saleem M Rana, Chhabi L Ranabhat, Sowmya R Rao, Amany H Refaat, Mark Riddle, Gholamreza Roshandel, George Mugambage Ruhago, Muhammad Muhammad Saleh, Juan R Sanabria, Monika Sawhney, Sadaf G Sepanlou, Tesfaye Setegn, Karen Sliwa, Chandrashekhar T Sreeramareddy, Bryan L Sykes, Mohammad Tavakkoli, Bemnet Amare Tedla, Abdullah S Terkawi, Kingsley Ukwaja, Olalekan A Uthman, Ronny Westerman, Mamo Wubshet, Muluken A Yenesew, Naohiro Yonemoto, Mustafa Z Younis, Zoubida Zaidi, Maysaa El Sayed Zaki, Abdullah A Al Rabeeah, Haidong Wang, Mohsen Naghavi, Theo Vos, Alan D Lopez, Christopher J L Murray, Ali H Mokdad
Diarrheal diseases (DD) are leading causes of disease burden, death, and disability, especially in children in low-income settings. DD can also impact a child's potential livelihood through stunted physical growth, cognitive impairment, and other sequelae. As part of the Global Burden of Disease Study, we estimated DD burden, and the burden attributable to specific risk factors and particular etiologies, in the Eastern Mediterranean Region (EMR) between 1990 and 2013. For both sexes and all ages, we calculated disability-adjusted life years (DALYs), which are the sum of years of life lost and years lived with disability...
December 7, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27914185/use-of-peers-to-improve-adherence-to-antiretroviral-therapy-a-global-network-meta-analysis
#8
REVIEW
Steve Kanters, Jay Jh Park, Keith Chan, Nathan Ford, Jamie Forrest, Kristian Thorlund, Jean B Nachega, Edward J Mills
INTRODUCTION: It is unclear whether using peers can improve adherence to antiretroviral therapy (ART). To construct the World Health Organization's global guidance on adherence interventions, we conducted a systematic review and network meta-analysis to determine the effectiveness of using peers for achieving adequate adherence and viral suppression. METHODS: We searched for randomized clinical trials of peer-based interventions to promote adherence to ART in HIV populations...
2016: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/27898679/patient-reported-barriers-to-adherence-to-antiretroviral-therapy-a-systematic-review-and-meta-analysis
#9
REVIEW
Zara Shubber, Edward J Mills, Jean B Nachega, Rachel Vreeman, Marcelo Freitas, Peter Bock, Sabin Nsanzimana, Martina Penazzato, Tsitsi Appolo, Meg Doherty, Nathan Ford
BACKGROUND: Maintaining high levels of adherence to antiretroviral therapy (ART) is a challenge across settings and populations. Understanding the relative importance of different barriers to adherence will help inform the targeting of different interventions and future research priorities. METHODS AND FINDINGS: We searched MEDLINE via PubMed, Embase, Web of Science, and PsychINFO from 01 January 1997 to 31 March 2016 for studies reporting barriers to adherence to ART...
November 2016: PLoS Medicine
https://www.readbyqxmd.com/read/27864000/timing-of-initiation-of-antiretroviral-therapy-and-adverse-pregnancy-outcomes-a-systematic-review-and-meta-analysis
#10
Olalekan A Uthman, Jean B Nachega, Jean Anderson, Steve Kanters, Edward J Mills, Françoise Renaud, Shaffiq Essajee, Meg C Doherty, Lynne M Mofenson
BACKGROUND: Although lifelong combination antiretroviral therapy (ART) is recommended for all individuals with HIV, few data exist for pregnancy outcomes associated with ART initiation before conception. We assessed adverse pregnancy outcomes associated with ART initiated before conception compared with that of ART started after conception. METHODS: We did a systematic review of studies from low-income, middle-income, and high-income countries by searching the Cochrane Central Register of Controlled Trials, Embase, LILACS, MEDLINE, Toxline, Web of Knowledge, and WHO Global Index Medicus and trials in progress (International Clinical Trials Registry Platform) for randomised trials, quasi-randomised trials, and prospective cohort studies done between Jan 1, 1980, and June 1, 2016, in which timing of ART initiation in pregnant women living with HIV was reported...
January 2017: Lancet HIV
https://www.readbyqxmd.com/read/27863996/interventions-to-improve-adherence-to-antiretroviral-therapy-a-systematic-review-and-network-meta-analysis
#11
Steve Kanters, Jay J H Park, Keith Chan, Maria Eugenia Socias, Nathan Ford, Jamie I Forrest, Kristian Thorlund, Jean B Nachega, Edward J Mills
BACKGROUND: High adherence to antiretroviral therapy is crucial to the success of HIV treatment. We evaluated comparative effectiveness of adherence interventions with the aim of informing the WHO's global guidance on interventions to increase adherence. METHODS: For this systematic review and network meta-analysis, we searched for randomised controlled trials of interventions that aimed to improve adherence to antiretroviral therapy regimens in populations with HIV...
January 2017: Lancet HIV
https://www.readbyqxmd.com/read/27475643/community-based-interventions-to-improve-and-sustain-antiretroviral-therapy-adherence-retention-in-hiv-care-and-clinical-outcomes-in-low-and-middle-income-countries-for-achieving-the-unaids-90-90-90-targets
#12
REVIEW
Jean B Nachega, Olatunji Adetokunboh, Olalekan A Uthman, Amy W Knowlton, Frederick L Altice, Mauro Schechter, Omar Galárraga, Elvin Geng, Karl Peltzer, Larry W Chang, Gilles Van Cutsem, Shabbar S Jaffar, Nathan Ford, Claude A Mellins, Robert H Remien, Edward J Mills
Little is known about the effect of community versus health facility-based interventions to improve and sustain antiretroviral therapy (ART) adherence, virologic suppression, and retention in care among HIV-infected individuals in low- and middle-income countries (LMICs). We systematically searched four electronic databases for all available randomized controlled trials (RCTs) and comparative cohort studies in LMICs comparing community versus health facility-based interventions. Relative risks (RRs) for pre-defined adherence, treatment engagement (linkage and retention in care), and relevant clinical outcomes were pooled using random effect models...
October 2016: Current HIV/AIDS Reports
https://www.readbyqxmd.com/read/27175068/acceptability-and-feasibility-of-mhealth-and-community-based-directly-observed-antiretroviral-therapy-to-prevent-mother-to-child-hiv-transmission-in-south-african-pregnant-women-under-option-b-an-exploratory-study
#13
Jean B Nachega, Donald Skinner, Larissa Jennings, Jessica F Magidson, Frederick L Altice, Jessica G Burke, Richard T Lester, Olalekan A Uthman, Amy R Knowlton, Mark F Cotton, Jean R Anderson, Gerhard B Theron
OBJECTIVE: To examine the acceptability and feasibility of mobile health (mHealth)/short message service (SMS) and community-based directly observed antiretroviral therapy (cDOT) as interventions to improve antiretroviral therapy (ART) adherence for preventing mother-to-child human immunodeficiency virus (HIV) transmission (PMTCT). DESIGN AND METHODS: A mixed-method approach was used. Two qualitative focus group discussions with HIV-infected pregnant women (n=20) examined the acceptability and feasibility of two ART adherence interventions for PMTCT: 1) SMS text messaging and 2) patient-nominated cDOT supporters...
2016: Patient Preference and Adherence
https://www.readbyqxmd.com/read/26836786/incidence-of-stage-3-chronic-kidney-disease-and-progression-on-tenofovir-based-regimens
#14
Hadas Zachor, Rhoderick Machekano, Michelle M Estrella, Peter J Veldkamp, Michele D Zeier, Olalekan A Uthman, Jantjie J Taljaard, Mohammed R Moosa, Jean B Nachega
OBJECTIVE: To describe the incidence of rapid kidney function decline (RKFD), and stage 3 chronic kidney disease (CKD) in HIV-1-infected adults initiated on tenofovir-containing antiretroviral therapy. METHODS: A retrospective cohort study at the infectious diseases clinic of Tygerberg Academic Hospital in Cape Town, South Africa. Patients with more than 3 ml/min per year decline in estimated glomerular filtration were classified as having RKFD, and stage 3 CKD was defined as a value less than 60 ml/min per 1...
May 15, 2016: AIDS
https://www.readbyqxmd.com/read/26148280/optimal-timing-of-antiretroviral-therapy-initiation-for-hiv-infected-adults-with-newly-diagnosed-pulmonary-tuberculosis-a-systematic-review-and-meta-analysis
#15
REVIEW
Olalekan A Uthman, Charles Okwundu, Kayode Gbenga, Jimmy Volmink, David Dowdy, Alimuddin Zumla, Jean B Nachega
BACKGROUND: Initiation of antiretroviral therapy (ART) during tuberculosis (TB) treatment remains challenging. PURPOSE: To assess evidence from randomized, controlled trials of the timing of ART initiation in HIV-infected adults with newly diagnosed pulmonary TB. DATA SOURCES: PubMed, EMBASE, Cochrane Central Register of Controlled Trials, conference abstracts, and ClinicalTrials.gov (from January 1980 to May 2015). STUDY SELECTION: Randomized, controlled trials evaluating early versus delayed ART initiation (1 to 4 weeks vs...
July 7, 2015: Annals of Internal Medicine
https://www.readbyqxmd.com/read/25859596/cd41-t-cell-recovery-during-suppression-of-hiv-replication-an-international-comparison-of-the-immunological-efficacy-of-antiretroviral-therapy-in-north-america-asia-and-africa
#16
Elvin H Geng, Torsten B Neilands, Rodolphe Thièbaut, Mwebesa Bosco Bwana, Denis Nash, Richard D Moore, Robin Wood, Djimon Marcel Zannou, Keri N Althoff, Poh Lian Lim, Jean B Nachega, Philippa J Easterbrook, Andrew Kambugu, Francesca Little, Gertrude Nakigozi, Damalie Nakanjako, Valerian Kiggundu, Patrick Chung Ki Li, David R Bangsberg, Matthew P Fox, HansW Prozesky, Peter W Hunt, Mary-Ann Davies, Steven J Reynolds, Matthias Egger, Constantin T Yiannoutsos, Eric V Vittinghoff, Steven G Deeks, Jeffrey N Martin
BACKGROUND: Even among HIV-infected patients who fully suppress plasma HIV RNA replication on antiretroviral therapy, genetic (e.g. CCL3L1 copy number), viral (e.g. tropism) and environmental (e.g. chronic exposure to microbial antigens) factors influence CD4 recovery. These factors differ markedly around the world and therefore the expected CD4 recovery during HIV RNA suppression may differ globally. METHODS: We evaluated HIV-infected adults from North America, West Africa, East Africa, Southern Africa and Asia starting non-nucleoside reverse transcriptase inhibitorbased regimens containing efavirenz or nevirapine, who achieved at least one HIV RNA level <500/ml in the first year of therapy and observed CD4 changes during HIV RNA suppression...
February 2015: International Journal of Epidemiology
https://www.readbyqxmd.com/read/25822083/parental-absence-from-clinic-predicts-human-immunodeficiency-virus-treatment-failure-in-adolescents
#17
Elizabeth D Lowenthal, Tafireyi Marukutira, Ontibile Tshume, Jennifer Chapman, Jean B Nachega, Gabriel Anabwani, Robert Gross
No abstract text is available yet for this article.
May 2015: JAMA Pediatrics
https://www.readbyqxmd.com/read/25558105/association-between-antiretroviral-therapy-adherence-and-employment-status-systematic-review-and-meta-analysis
#18
REVIEW
Jean B Nachega, Olalekan A Uthman, Karl Peltzer, Lindsey A Richardson, Edward J Mills, Kofi Amekudzi, Alice Ouédraogo
OBJECTIVE: To assess the association between the employment status of human immunodeficiency virus (HIV)-infected individuals and adherence to antiretroviral therapy (ART). METHODS: We searched the Medline, Embase and Cochrane Central Register of Controlled Trials databases for studies reporting ART adherence and employment status published between January 1980 and September 2014. Information from a wide range of other sources, including the grey literature, was also analysed...
January 1, 2015: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/25513031/hiv-provider-patient-communication-regarding-cardiovascular-risk-results-from-the-aids-treatment-for-life-international-survey
#19
Renslow Sherer, Suniti Solomon, Mauro Schechter, Jean B Nachega, Jurgen Rockstroh, José M Zuniga
DESIGN: Few global studies have assessed HIV clinician-patient communication regarding cardiovascular disease (CVD) risks. METHODS: We conducted a multicountry, comparative, cross-sectional survey of HIV-infected individuals in 12 countries on 5 continents in 2010, with 100 to 200 enrollees per country. HIV-infected adults >17 years and on antiretroviral therapy were recruited in clinics and community organizations and surveyed via direct interview, telephone encounter, or online...
July 2014: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/25493592/emerging-antiretroviral-drug-resistance-in-sub-saharan-africa-novel-affordable-technologies-are-needed-to-provide-resistance-testing-for-individual-and-public-health-benefits
#20
Gert U van Zyl, Lisa M Frenkel, Michael H Chung, Wolfgang Preiser, John W Mellors, Jean B Nachega
No abstract text is available yet for this article.
November 28, 2014: AIDS
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