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https://www.readbyqxmd.com/read/27914185/use-of-peers-to-improve-adherence-to-antiretroviral-therapy-a-global-network-meta-analysis
#1
REVIEW
Steve Kanters, Jay Jh Park, Keith Chan, Nathan Ford, Jamie Forrest, Kristian Thorlund, Jean B Nachega, Edward J Mills
INTRODUCTION: It is unclear whether using peers can improve adherence to antiretroviral therapy (ART). To construct the World Health Organization's global guidance on adherence interventions, we conducted a systematic review and network meta-analysis to determine the effectiveness of using peers for achieving adequate adherence and viral suppression. METHODS: We searched for randomized clinical trials of peer-based interventions to promote adherence to ART in HIV populations...
2016: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/27898679/patient-reported-barriers-to-adherence-to-antiretroviral-therapy-a-systematic-review-and-meta-analysis
#2
Zara Shubber, Edward J Mills, Jean B Nachega, Rachel Vreeman, Marcelo Freitas, Peter Bock, Sabin Nsanzimana, Martina Penazzato, Tsitsi Appolo, Meg Doherty, Nathan Ford
BACKGROUND: Maintaining high levels of adherence to antiretroviral therapy (ART) is a challenge across settings and populations. Understanding the relative importance of different barriers to adherence will help inform the targeting of different interventions and future research priorities. METHODS AND FINDINGS: We searched MEDLINE via PubMed, Embase, Web of Science, and PsychINFO from 01 January 1997 to 31 March 2016 for studies reporting barriers to adherence to ART...
November 2016: PLoS Medicine
https://www.readbyqxmd.com/read/27864000/timing-of-initiation-of-antiretroviral-therapy-and-adverse-pregnancy-outcomes-a-systematic-review-and-meta-analysis
#3
Olalekan A Uthman, Jean B Nachega, Jean Anderson, Steve Kanters, Edward J Mills, Françoise Renaud, Shaffiq Essajee, Meg C Doherty, Lynne M Mofenson
BACKGROUND: Although lifelong combination antiretroviral therapy (ART) is recommended for all individuals with HIV, few data exist for pregnancy outcomes associated with ART initiation before conception. We assessed adverse pregnancy outcomes associated with ART initiated before conception compared with that of ART started after conception. METHODS: We did a systematic review of studies from low-income, middle-income, and high-income countries by searching the Cochrane Central Register of Controlled Trials, Embase, LILACS, MEDLINE, Toxline, Web of Knowledge, and WHO Global Index Medicus and trials in progress (International Clinical Trials Registry Platform) for randomised trials, quasi-randomised trials, and prospective cohort studies done between Jan 1, 1980, and June 1, 2016, in which timing of ART initiation in pregnant women living with HIV was reported...
November 15, 2016: Lancet HIV
https://www.readbyqxmd.com/read/27863996/interventions-to-improve-adherence-to-antiretroviral-therapy-a-systematic-review-and-network-meta-analysis
#4
Steve Kanters, Jay J H Park, Keith Chan, Maria Eugenia Socias, Nathan Ford, Jamie I Forrest, Kristian Thorlund, Jean B Nachega, Edward J Mills
BACKGROUND: High adherence to antiretroviral therapy is crucial to the success of HIV treatment. We evaluated comparative effectiveness of adherence interventions with the aim of informing the WHO's global guidance on interventions to increase adherence. METHODS: For this systematic review and network meta-analysis, we searched for randomised controlled trials of interventions that aimed to improve adherence to antiretroviral therapy regimens in populations with HIV...
November 15, 2016: Lancet HIV
https://www.readbyqxmd.com/read/27475643/community-based-interventions-to-improve-and-sustain-antiretroviral-therapy-adherence-retention-in-hiv-care-and-clinical-outcomes-in-low-and-middle-income-countries-for-achieving-the-unaids-90-90-90-targets
#5
REVIEW
Jean B Nachega, Olatunji Adetokunboh, Olalekan A Uthman, Amy W Knowlton, Frederick L Altice, Mauro Schechter, Omar Galárraga, Elvin Geng, Karl Peltzer, Larry W Chang, Gilles Van Cutsem, Shabbar S Jaffar, Nathan Ford, Claude A Mellins, Robert H Remien, Edward J Mills
Little is known about the effect of community versus health facility-based interventions to improve and sustain antiretroviral therapy (ART) adherence, virologic suppression, and retention in care among HIV-infected individuals in low- and middle-income countries (LMICs). We systematically searched four electronic databases for all available randomized controlled trials (RCTs) and comparative cohort studies in LMICs comparing community versus health facility-based interventions. Relative risks (RRs) for pre-defined adherence, treatment engagement (linkage and retention in care), and relevant clinical outcomes were pooled using random effect models...
October 2016: Current HIV/AIDS Reports
https://www.readbyqxmd.com/read/27175068/acceptability-and-feasibility-of-mhealth-and-community-based-directly-observed-antiretroviral-therapy-to-prevent-mother-to-child-hiv-transmission-in-south-african-pregnant-women-under-option-b-an-exploratory-study
#6
Jean B Nachega, Donald Skinner, Larissa Jennings, Jessica F Magidson, Frederick L Altice, Jessica G Burke, Richard T Lester, Olalekan A Uthman, Amy R Knowlton, Mark F Cotton, Jean R Anderson, Gerhard B Theron
OBJECTIVE: To examine the acceptability and feasibility of mobile health (mHealth)/short message service (SMS) and community-based directly observed antiretroviral therapy (cDOT) as interventions to improve antiretroviral therapy (ART) adherence for preventing mother-to-child human immunodeficiency virus (HIV) transmission (PMTCT). DESIGN AND METHODS: A mixed-method approach was used. Two qualitative focus group discussions with HIV-infected pregnant women (n=20) examined the acceptability and feasibility of two ART adherence interventions for PMTCT: 1) SMS text messaging and 2) patient-nominated cDOT supporters...
2016: Patient Preference and Adherence
https://www.readbyqxmd.com/read/26836786/incidence-of-stage-3-chronic-kidney-disease-and-progression-on-tenofovir-based-regimens
#7
Hadas Zachor, Rhoderick Machekano, Michelle M Estrella, Peter J Veldkamp, Michele D Zeier, Olalekan A Uthman, Jantjie J Taljaard, Mohammed R Moosa, Jean B Nachega
OBJECTIVE: To describe the incidence of rapid kidney function decline (RKFD), and stage 3 chronic kidney disease (CKD) in HIV-1-infected adults initiated on tenofovir-containing antiretroviral therapy. METHODS: A retrospective cohort study at the infectious diseases clinic of Tygerberg Academic Hospital in Cape Town, South Africa. Patients with more than 3 ml/min per year decline in estimated glomerular filtration were classified as having RKFD, and stage 3 CKD was defined as a value less than 60 ml/min per 1...
May 15, 2016: AIDS
https://www.readbyqxmd.com/read/26148280/optimal-timing-of-antiretroviral-therapy-initiation-for-hiv-infected-adults-with-newly-diagnosed-pulmonary-tuberculosis-a-systematic-review-and-meta-analysis
#8
REVIEW
Olalekan A Uthman, Charles Okwundu, Kayode Gbenga, Jimmy Volmink, David Dowdy, Alimuddin Zumla, Jean B Nachega
BACKGROUND: Initiation of antiretroviral therapy (ART) during tuberculosis (TB) treatment remains challenging. PURPOSE: To assess evidence from randomized, controlled trials of the timing of ART initiation in HIV-infected adults with newly diagnosed pulmonary TB. DATA SOURCES: PubMed, EMBASE, Cochrane Central Register of Controlled Trials, conference abstracts, and ClinicalTrials.gov (from January 1980 to May 2015). STUDY SELECTION: Randomized, controlled trials evaluating early versus delayed ART initiation (1 to 4 weeks vs...
July 7, 2015: Annals of Internal Medicine
https://www.readbyqxmd.com/read/25859596/cd41-t-cell-recovery-during-suppression-of-hiv-replication-an-international-comparison-of-the-immunological-efficacy-of-antiretroviral-therapy-in-north-america-asia-and-africa
#9
Elvin H Geng, Torsten B Neilands, Rodolphe Thièbaut, Mwebesa Bosco Bwana, Denis Nash, Richard D Moore, Robin Wood, Djimon Marcel Zannou, Keri N Althoff, Poh Lian Lim, Jean B Nachega, Philippa J Easterbrook, Andrew Kambugu, Francesca Little, Gertrude Nakigozi, Damalie Nakanjako, Valerian Kiggundu, Patrick Chung Ki Li, David R Bangsberg, Matthew P Fox, HansW Prozesky, Peter W Hunt, Mary-Ann Davies, Steven J Reynolds, Matthias Egger, Constantin T Yiannoutsos, Eric V Vittinghoff, Steven G Deeks, Jeffrey N Martin
BACKGROUND: Even among HIV-infected patients who fully suppress plasma HIV RNA replication on antiretroviral therapy, genetic (e.g. CCL3L1 copy number), viral (e.g. tropism) and environmental (e.g. chronic exposure to microbial antigens) factors influence CD4 recovery. These factors differ markedly around the world and therefore the expected CD4 recovery during HIV RNA suppression may differ globally. METHODS: We evaluated HIV-infected adults from North America, West Africa, East Africa, Southern Africa and Asia starting non-nucleoside reverse transcriptase inhibitorbased regimens containing efavirenz or nevirapine, who achieved at least one HIV RNA level <500/ml in the first year of therapy and observed CD4 changes during HIV RNA suppression...
February 2015: International Journal of Epidemiology
https://www.readbyqxmd.com/read/25822083/parental-absence-from-clinic-predicts-human-immunodeficiency-virus-treatment-failure-in-adolescents
#10
Elizabeth D Lowenthal, Tafireyi Marukutira, Ontibile Tshume, Jennifer Chapman, Jean B Nachega, Gabriel Anabwani, Robert Gross
No abstract text is available yet for this article.
May 2015: JAMA Pediatrics
https://www.readbyqxmd.com/read/25558105/association-between-antiretroviral-therapy-adherence-and-employment-status-systematic-review-and-meta-analysis
#11
REVIEW
Jean B Nachega, Olalekan A Uthman, Karl Peltzer, Lindsey A Richardson, Edward J Mills, Kofi Amekudzi, Alice Ouédraogo
OBJECTIVE: To assess the association between the employment status of human immunodeficiency virus (HIV)-infected individuals and adherence to antiretroviral therapy (ART). METHODS: We searched the Medline, Embase and Cochrane Central Register of Controlled Trials databases for studies reporting ART adherence and employment status published between January 1980 and September 2014. Information from a wide range of other sources, including the grey literature, was also analysed...
January 1, 2015: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/25513031/hiv-provider-patient-communication-regarding-cardiovascular-risk-results-from-the-aids-treatment-for-life-international-survey
#12
Renslow Sherer, Suniti Solomon, Mauro Schechter, Jean B Nachega, Jurgen Rockstroh, José M Zuniga
DESIGN: Few global studies have assessed HIV clinician-patient communication regarding cardiovascular disease (CVD) risks. METHODS: We conducted a multicountry, comparative, cross-sectional survey of HIV-infected individuals in 12 countries on 5 continents in 2010, with 100 to 200 enrollees per country. HIV-infected adults >17 years and on antiretroviral therapy were recruited in clinics and community organizations and surveyed via direct interview, telephone encounter, or online...
July 2014: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/25493592/emerging-antiretroviral-drug-resistance-in-sub-saharan-africa-novel-affordable-technologies-are-needed-to-provide-resistance-testing-for-individual-and-public-health-benefits
#13
Gert U van Zyl, Lisa M Frenkel, Michael H Chung, Wolfgang Preiser, John W Mellors, Jean B Nachega
No abstract text is available yet for this article.
November 28, 2014: AIDS
https://www.readbyqxmd.com/read/25426940/the-combination-of-pill-count-and-self-reported-adherence-is-a-strong-predictor-of-first-line-art-failure-for-adults-in-south-africa
#14
Peng Wu, Brent A Johnson, Jean B Nachega, Baohua Wu, Claudia E Ordonez, Anna Q Hare, Rachel Kearns, Richard Murphy, Henry Sunpath, Vincent C Marconi
BACKGROUND: Suboptimal adherence to antiretroviral therapy (ART) is a strong predictor of virologic failure (VF) among people with HIV. Various methods such as patient self-report, pill counts and pharmacy refills have been utilized to monitor adherence. However, there are limited data on the accuracy of combining methods to better predict VF in routine clinical settings. We examined various methods to assess adherence including pill count, medication possession ratio (MPR), and self-reported adherence in order to determine which was most highly associated with VF after > 6 months on ART...
2014: Current HIV Research
https://www.readbyqxmd.com/read/25276515/can-we-stop-aids-with-antiretroviral-based-treatment-as-prevention
#15
REVIEW
Edward J Mills, Jean B Nachega, Nathan Ford
Challenges to scaling up treatment as prevention (TasP) of HIV transmission are considerable in the developing-world context and include accessing at-risk populations, human resource shortages, adherence and retention in care, access to newer treatments, measurement of treatment effects, and long-term sustainable funding. Optimism about ending AIDS needs to be tempered by the realities of the logistic challenges of strengthening health systems in countries most affected and by balancing TasP with overall combination prevention approaches...
March 2013: Global Health, Science and Practice
https://www.readbyqxmd.com/read/25072584/guiding-the-development-of-family-medicine-training-in-africa-through-collaboration-with-the-medical-education-partnership-initiative
#16
Robert J Mash, Marietjie R de Villiers, Kalay Moodley, Jean B Nachega
Africa's health care challenges include a high burden of disease, low life expectancy, health workforce shortages, and varying degrees of commitment to primary health care on the part of policy makers and government officials. One overarching goal of the Medical Education Partnership Initiative (MEPI) is to develop models of medical education in Sub-Saharan Africa. To do this, MEPI has created a network of universities and other institutions that, among other things, recognizes the importance of supporting training programs in family medicine...
August 2014: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/25038748/depression-and-adherence-to-antiretroviral-therapy-in-low-middle-and-high-income-countries-a-systematic-review-and-meta-analysis
#17
REVIEW
Olalekan A Uthman, Jessica F Magidson, Steven A Safren, Jean B Nachega
We investigated the associations between depressive symptoms and adherence to antiretroviral therapy (ART) among people living with HIV (PLHIV). We searched the PubMed, EMBASE and Cochrane CENTRAL databases for studies that reported an association between depression and adherence to ART as a primary or secondary outcome. We used a random-effect model to pool the risk estimates from the individual studies. The odds ratio (OR) with their 95 % CIs were used as summary estimates. Of 2861 citations, 111 studies that recruited 42,366 PLHIV met our inclusion criteria...
September 2014: Current HIV/AIDS Reports
https://www.readbyqxmd.com/read/24926028/addressing-the-achilles-heel-in-the-hiv-care-continuum-for-the-success-of-a-test-and-treat-strategy-to-achieve-an-aids-free-generation
#18
Jean B Nachega, Olalekan A Uthman, Carlos del Rio, Michael J Mugavero, Helen Rees, Edward J Mills
Mathematical models and recent data from ecological, observational, and experimental studies show that antiretroviral therapy (ART) is effective for both treatment and prevention of HIV, validating the treatment as prevention (TasP) approach. Data from a variety of settings, including resource-rich and -limited sites, show that patient attrition occurs at each stage of the human immunodeficiency virus (HIV) treatment cascade, starting with the percent unaware of their HIV infection in a population and linkage to care after diagnosis, assessment of ART readiness, receipt of ART, and finally long-term virologic suppression...
July 2014: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/24718379/hiv-provider-patient-communication-regarding-cardiovascular-risk-results-from-the-aids-treatment-for-life-international-survey
#19
Renslow Sherer, Suniti Solomon, Mauro Schechter, Jean B Nachega, Jurgen Rockstroh, José M Zuniga
DESIGN: Few global studies have assessed HIV clinician-patient communication regarding cardiovascular disease (CVD) risks. METHODS: We conducted a multicountry, comparative, cross-sectional survey of HIV-infected individuals in 12 countries on 5 continents in 2010, with 100 to 200 enrollees per country. HIV-infected adults >17 years and on antiretroviral therapy were recruited in clinics and community organizations and surveyed via direct interview, telephone encounter, or online...
July 2014: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/24585560/editorial-commentary-risks-and-benefits-of-tenofovir-in-the-context-of-kidney-dysfunction-in-sub-saharan-africa
#20
EDITORIAL
Michelle M Estrella, Mohammed R Moosa, Jean B Nachega
No abstract text is available yet for this article.
May 2014: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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