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https://www.readbyqxmd.com/read/28879311/recent-advances-in-topical-anesthesia
#1
REVIEW
Hyo-Seol Lee
Topical anesthetics act on the peripheral nerves and reduce the sensation of pain at the site of application. In dentistry, they are used to control local pain caused by needling, placement of orthodontic bands, the vomiting reflex, oral mucositis, and rubber-dam clamp placement. Traditional topical anesthetics contain lidocaine or benzocaine as active ingredients and are used in the form of solutions, creams, gels, and sprays. Eutectic mixtures of local anesthesia cream, a mixture of various topical anesthetics, has been reported to be more potent than other anesthetics...
December 2016: J Dent Anesth Pain Med
https://www.readbyqxmd.com/read/28879245/effects-of-high-dose-capsaicin-on-tmd-subjects-a-randomized-clinical-study
#2
B K Campbell, R B Fillingim, S Lee, R Brao, D D Price, J K Neubert
Temporomandibular joint disorder (TMD) is a complex musculoskeletal disorder that presents with pain, limited jaw opening, and abnormal noises in the temporomandibular joint. Despite the significant impact that TMD has in terms of suffering and financial burden, relatively few new treatments have emerged; therefore, development of novel treatments to treat TMD pain remains a high priority. The rationale of this study was to use a double-blind, vehicle-controlled clinical trial to evaluate the effects of a high-concentration (8%) capsaicin cream on TMD...
January 2017: JDR Clinical and Translational Research
https://www.readbyqxmd.com/read/28877863/the-paget-trial-a-multicenter-observational-cohort-intervention-study-for-the-clinical-efficacy-safety-and-immunological-response-of-topical-5-imiquimod-cream-for-vulvar-paget-disease
#3
Michelle van der Linden, Kim Meeuwis, Colette van Hees, Eleonora van Dorst, Johan Bulten, Tjalling Bosse, Joanna IntHout, Dorry Boll, Brigitte Slangen, Manon van Seters, Marc van Beurden, Mariëtte van Poelgeest, Joanne de Hullu
BACKGROUND: Vulvar Paget disease is a rare skin disorder, which is most common in postmenopausal Caucasian women. They usually present with an erythematous plaque that may show fine or typical "cake icing" scaling or ulceration that may cause itching, pain, irritation, or a burning sensation. Although most cases are noninvasive, vulvar Paget disease may be invasive or associated with an underlying vulvar or distant adenocarcinoma. The histological evidence of so-called "Paget cells" with abundant pale cytoplasm in the epithelium confirms the diagnosis...
September 6, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28834579/topical-flurbiprofen-toxicosis-in-a-cat
#4
Elizabeth M Yi, Elizabeth Leech
OBJECTIVE: To describe the clinical presentation and treatment of a cat with flurbiprofen toxicosis due to topical cream exposure. CASE SUMMARY: A 3-year-old castrated male domestic shorthair cat presented to an emergency and referral center for acute lethargy, hematemesis, and anemia. Severe azotemia was observed on serum biochemistry panel. The patient's anemia was treated with packed RBC transfusion, and treatment with crystalloid fluids, famotidine, pantoprazole, ampicillin, and sucralfate were begun on presentation...
August 23, 2017: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/28831937/-pain-reduction-during-vaccination-of-young-children
#5
B van Vreeswijk, N G P Bos-Veneman, S A Reijneveld
- Children have the right to pain mitigation during vaccination.- There are several simple, non-costly and safe interventions to effectively reduce pain during vaccination.- To improve the Dutch vaccination praxis, it is essential to train professionals in the use of these interventions.- Using the vaccination technique described in the guideline of the Dutch National Immunisation Programme results in pain reduction.- As a pain-reducing intervention at every vaccination procedure, the healthcare professional can give the child and parents a feeling of being in control by explaining about the vaccination procedure, pain and pain reduction and by vaccinating in calm, low-stimulus surroundings...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28803262/topic-anaesthesia-with-a-eutectic-mixture-of-lidocaine-prilocaine-cream-after-elective-caesarean-section-a-randomised-placebo-controlled-trial
#6
Thomas Grosse-Steffen, Malin Krämer, Benjamin Tuschy, Christel Weiss, Marc Sütterlin, Sebastian Berlit
PURPOSE: Aim of the study was to investigate the topical application of a eutectic mixture of lidocaine/prilocaine (EMLA(®)) cream after caesarean section (CS) and its effect on postoperative pain, time to mobilisation, and time to discharge. MATERIALS AND METHODS: A total of 189 pregnant women were enrolled; full data sets were available for 139 of them, who were prospectively randomised to receive either placebo (control group) or EMLA(®) cream (study group) on the CS lesion directly as well as 24 h after surgery...
August 12, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28775197/protocol-for-a-randomised-controlled-trial-of-90-kanuka-honey-versus-5-aciclovir-for-the-treatment-of-herpes-simplex-labialis-in-the-community-setting
#7
Alex Semprini, Joseph Singer, Nicholas Shortt, Irene Braithwaite, Richard Beasley
INTRODUCTION: Worldwide, about 90% of people are infected with the herpes simplex virus, 30% of whom will experience recurrent herpes simplex labialis, commonly referred to as 'cold sores', which can last up to 10 days. The most common treatment is aciclovir cream which reduces healing time by just half a day compared with no specific treatment. This is a protocol for a randomised controlled trial (RCT) to determine the efficacy of medical grade kanuka honey-based topical treatment (Honevo) in reducing the healing time and pain of cold sores, compared with topical aciclovir treatment (Viraban)...
August 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/28759158/no-sting-barrier-film-to-protect-skin-in-adult-patients-findings-from-a-scoping-review-with-implications-for-evidence-based-practice
#8
Chiara Micheli, Alvisa Palese, Federica Canzan, Elisa Ambrosi
BACKGROUND: In the industrialized world, approximately 1-1.5% of the population has received treatments for skin lesions. In the 1990s, a polymeric barrier film called the No Sting Barrier Film (NSBF) was developed as an alternative to petrolatum-based ointments and zinc oxide formulas. To date, few studies have explored the effectiveness of NSBF in protecting skin integrity. AIMS: To map the methods, fields and outcomes used to produce evidence on NSBF effectiveness...
July 31, 2017: Worldviews on Evidence-based Nursing
https://www.readbyqxmd.com/read/28741431/-express-topical-moringin-cream-relieves-neuropathic-pain-by-suppression-of-inflammatory-pathway-and-voltage-gated-ion-channels-in-murine-model-of-multiple-sclerosis
#9
Sabrina Giacoppo, Renato Iori, Placido Bramanti, Emanuela Mazzon
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28729062/pharmacological-activation-of-ampk-inhibits-incision-evoked-mechanical-hypersensitivity-and-the-development-of-hyperalgesic-priming-in-mice
#10
Michael D Burton, Dipti V Tillu, Khadijah Mazhar, Galo L Mejia, Marina N Asiedu, Kufreobong Inyang, Travis Hughes, Bo Lian, Gregory Dussor, Theodore J Price
New therapeutics to manage post-surgical pain are needed to mitigate the liabilities of opioid and other analgesics. Our previous work shows that key modulators of excitability in peripheral nociceptors, such as extracellular signal-regulated kinases (ERK) are inhibited by activation of adenosine monophosphate activated protein kinase (AMPK). We hypothesized that AMPK activation would attenuate acute incision-evoked mechanical hypersensitivity and the development of hyperalgesic priming caused by surgery in mice...
July 17, 2017: Neuroscience
https://www.readbyqxmd.com/read/28719485/does-the-application-of-heat-gel-pack-after-eutectic-mixture-of-local-anesthetic-cream-improve-venipuncture-or-intravenous-cannulation-success-rate-in-children-a-randomized-control-trial
#11
Silvana Schreiber, Giorgio Cozzi, Giuseppa Patti, Andrea Taddio, Marcella Montico, Chiara Pierobon, Egidio Barbi
OBJECTIVE: Needle-related procedures are the most common sources of pain for children in the hospital setting. The most used topical anesthetic, eutectic mixture of local anesthetic (EMLA) cream, may cause transient vasoconstriction. It has been postulated that this vasoconstriction may decrease vein visualization. The application of heat gel pack after removal of EMLA cream in the site of venipuncture counteracts the vasoconstriction, improving vein visualization. We assessed using a prospective randomized controlled trial whether the application of heat gel pack increases the needle procedure success rate...
July 17, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28718248/outcome-of-0-2-glyceryltrinitrate-cream-versus-2-diltiazem-cream-in-the-treatment-of-chronic-anal-fissure
#12
Muhammad Siddique Khan, Ismail Akbar, Junaid Zeb, Salman Ahmad, Ajmal Khan
BACKGROUND: Anal fissure is a linear tear in the distal anal canal resulting from persistent hypertonia and spasm of the internal sphincter which results in mucosal ischemia. We have conducted a study in order to compare the outcome of 0.2% glyceryl trinitrate cream versus 2% diltiazem cream in the treatment of chronic anal fissure. METHODS: This randomized controlled trial (RCT) was carried out in the Department of Surgical "B" unit, at Ayub Teaching Hospital, Abbottabad, Pakistan from 15th June 2012 to 15th May 2015...
April 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28712478/comparison-of-effects-of-local-anesthesia-and-two-point-acupressure-on-the-severity-of-venipuncture-pain-among-hospitalized-6-12-year-old-children
#13
RANDOMIZED CONTROLLED TRIAL
Parisa Shahmohammadi Pour, Golnaz Foroogh Ameri, Majid Kazemi, Yones Jahani
The aim of the present study was to compare the effects of topical anesthesia and acupressure at the Yintang (Extra 1) and the Laogong (P-8) points on the severity of venipuncture pain among hospitalized 6-12-year-old children. A sample (n = 120) of 6-12-year-old hospitalized children was recruited from two teaching hospitals located in Rafsanjan, Iran. The children were allocated to the topical anesthesia, acupressure, and control groups. For children in the topical anesthesia and the acupressure groups, eutectic mixture of local anesthetic (EMLA) cream and two-point acupressure were used, respectively, prior to performing venipuncture, whereas children in the control group only received routine prevenipuncture care...
June 2017: Journal of Acupuncture and Meridian Studies
https://www.readbyqxmd.com/read/28705292/a-case-of-ischemia-induced-perianal-ulceration-mimicking-pyoderma-gangrenosum
#14
Michael Joseph Lavery, Nicola Cooke
A 68-year-old woman, with a 75-pack-year smoking history and a history of chronic excess alcohol intake, presented with a 5-week history of worsening perianal pain and ulceration. She recently had an inpatient admission with back pain and urinary tract infection during which she developed diarrhea and fecal incontinence. Initially, the perianal ulceration was diagnosed as severe irritant contact dermatitis and treated with barrier creams and topical clobetasone 17-butyrate 0.05% weight for weight, oxytetracycline 3...
2017: Skinmed
https://www.readbyqxmd.com/read/28688643/topical-anesthesia-for-staple-removal-from-surgical-wounds-on-the-knee-a-prospective-double-blind-randomized-trial
#15
Tzu-Hao Tseng, Ching-Chuan Jiang, Shau-Huai Fu, Tsung-Lin Lee, Ya-Hui Chuang, Hongsen Chiang
BACKGROUND: Staple removal from surgical wounds is painful. Only a few articles have provided expert opinions using anesthetic cream for such a problem; however, direct application of the anesthetic cream to a wound may cause infection. A safe alternative can be an anesthetic patch without wound contact. MATERIALS AND METHODS: This was a prospective, double-blind, randomized clinical trial. Sixty patients who underwent primary total knee replacement were assigned to an experimental group or control group...
July 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28673836/microneedles-enhance-topical-delivery-of-15-deoxy-%C3%AE-12-14-prostaglandin-j2-and-reduce-nociception-in-temporomandibular-joint-of-rats
#16
Cristina G Macedo, Amit K Jain, Michelle FranzMontan, Marcelo H Napimoga, Juliana T Clemente-Napimoga, Harvinder Singh Gill
The pain arising from temporomandibular disorders is often treated with opioids and agents that inhibit the immune response and are associated with substantial adverse effects and long-term risks. Thus, the development of new therapies that are safer and more effective is of great interest to patients and clinicians. 15-deoxy-Δ(12,14)-prostaglandin J2 (15d-PGJ2) is naturally produced in the human body and has anti-inflammatory properties. We have previously shown in a rat temporomandibular joint (TMJ) model that injection of 15d-PGJ2 into the rat TMJ can provide antinociceptive relief against a subsequent noxious challenge from formalin injection into the same TMJ...
June 30, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28653108/prevention-of-palmoplantar-erythrodysesthesia-in-patients-treated-with-pegylated-liposomal-doxorubicin-caelyx%C3%A2
#17
S Jung, J Sehouli, R Chekerov, F Kluschke, A Patzelt, H Fuss, F Knorr, J Lademann
PURPOSE: Palmoplantar erythrodysesthesia (PPE) is one of the most frequent side effects during systemic treatment with pegylated liposomal doxorubicin (PLD, Caelyx®). PPE lesions show a range of symptoms, from numbness to painful erosions, and can have a major impact on the quality of life in affected patients. Previously, a possible pathomechanism of PPE was found in doxorubicin-treated patients based on radical formation in the skin. Here, a preventive strategy using a topically applied ointment with a high radical protection factor was investigated...
June 26, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28645220/comparison-of-emla-cream-and-topical-lidocaine-tape-for-pain-relief-of-v-beam-laser-treatment
#18
Masaru Horikiri, Kazuki Ueda, Takao Sakaba
The authors compared the analgesic effects of two topical applications; Emla(®) cream (Sato Pharmaceutical Co. Ltd., Tokyo, Japan) and 60% lidocaine tape (Penles(®) tape; Maruho, Osaka, Japan). The authors examined 20 outpatients with capillary malformations. Emla(®) cream or Penles(®) tape was applied 1 h before laser irradiation using V-Beam. After V-Beam irradiation, pain intensity was measured using Pain Vision(®) (NIPRO, Osaka, Japan), while subjective pain was converted into numerical values using the VAS system...
June 23, 2017: Journal of Plastic Surgery and Hand Surgery
https://www.readbyqxmd.com/read/28632111/herpes-neolabialis-herpes-simplex-virus-type-1-infection-of-the-neolabia-in-a-transgender-woman
#19
Lian Elfering, Wouter B van der Sluis, Joline F Mermans, Marlon E Buncamper
A 24-year-old transgender woman consulted our outpatient clinic with a painful, itchy and red left labia. She underwent a penile inversion vaginoplasty 18 months before presentation. At physical examination of the left labia, erythema, edema and herpetic vesicles with ulceration were observed. A vesicle fluid swab was obtained and the presence of herpes simplex virus type 1 (HSV-1) was detected by PCR assay. Treatment consisted of oral valaciclovir (500 mg twice daily) for a total of five days.Topically-applied lidocaine cream (3%) was used for pain management...
July 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28579775/capsaicin-loaded-nanolipoidal-carriers-for-topical-application-design-characterization-and-in-vitro-in-vivo-evaluation
#20
Xia-Rong Wang, Si-Qian Gao, Xiao-Qian Niu, Long-Jian Li, Xiao-Ying Ying, Zhong-Jie Hu, Jian-Qing Gao
Capsaicin has been used in clinical applications for the treatment of pain disorders and inflammatory diseases. Given the strong pungency and high oil/water partition coefficient of capsaicin, capsaicin-loaded nanolipoidal carriers (NLCs) were designed to increase permeation and achieve the analgesic, anti-inflammatory effect with lower skin irritation. Capsaicin-loaded NLCs were prepared and later optimized by the Box-Behnken design. The physicochemical characterizations, morphology, and encapsulation of the capsaicin-loaded NLCs were subsequently confirmed...
2017: International Journal of Nanomedicine
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