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Topical pain creams

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https://www.readbyqxmd.com/read/28289111/oral-and-topical-antibiotics-for-clinically-infected-eczema-in-children-a-pragmatic-randomized-controlled-trial-in-ambulatory-care
#1
Nick A Francis, Matthew J Ridd, Emma Thomas-Jones, Christopher C Butler, Kerenza Hood, Victoria Shepherd, Charis A Marwick, Chao Huang, Mirella Longo, Mandy Wootton, Frank Sullivan
PURPOSE: Eczema may flare because of bacterial infection, but evidence supporting antibiotic treatment is of low quality. We aimed to determine the effect of oral and topical antibiotics in addition to topical emollient and corticosteroids in children with clinically infected eczema. METHODS: We employed a 3-arm, blinded, randomized controlled trial in UK ambulatory care. Children with clinical, non-severely infected eczema were randomized to receive oral and topical placebos (control), oral antibiotic (flucloxacillin) and topical placebo, or topical antibiotic (fusidic acid) and oral placebo, for 1 week...
March 2017: Annals of Family Medicine
https://www.readbyqxmd.com/read/28285487/load-carriage-related-paresthesias-part-2-meralgia-paresthetica
#2
Joseph J Knapik, Katy Reynolds, Robin Orr, Rodney Pope
This is the second of a two-part series addressing symptoms, evaluation, and treatment of load carriage- related paresthesias. Part 1 addressed rucksack palsy and digitalgia paresthetica; here, meralgia paresthetica (MP) is discussed. MP is a mononeuropathy involving the lateral femoral cutaneous nerve (LFCN). MP has been reported in load carriage situations where the LFCN was compressed by rucksack hipbelts, pistol belts, parachute harnesses, and body armor. In the US military, the rate of MP is 6.2 cases/10,000 personyears...
2017: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
https://www.readbyqxmd.com/read/28280381/topical-phenytoin-for-the-treatment-of-neuropathic-pain
#3
David J Kopsky, Jan M Keppel Hesselink
We developed and tested a new putative analgesic cream, based on the anticonvulsant phenytoin in patients suffering from treatment refractory neuropathic pain. The use of commercial topical analgesics is not widespread due to the facts that capsaicin creams or patches can give rise to side effects, such as burning, and analgesic patches (e.g., lidocaine 5% patches) have complex handling, especially for geriatric patients. Only in a few countries, compounded creams based on tricyclic antidepressants or other (co-)analgesics are available...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28274051/effectiveness-of-two-topical-anaesthetic-agents-used-along-with-audio-visual-aids-in-paediatric-dental-patients
#4
Nidhi Agarwal, Jayata Dhawan, Dipanshu Kumar, Ashish Anand, Karan Tangri
INTRODUCTION: Topical anaesthetic agents enable pain free intraoral procedures, symptomatic pain relief for toothache, superficial mucosal lesions and pain related to post extraction time. Most common anxiety provoking and fearful experience for children in dental operatory is administration of local anaesthesia because on seeing the needle, children usually become uncooperative. One of recent trend of behaviour management technique is using non-aversive techniques out of which audiovisual distraction has emerged as a very successful technique for managing children in dental settings...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28267948/a-clinical-audit-to-assess-the-efficacy-of-the-coolsense%C3%A2-pain-numbing-applicator-for-intravenous-cannulation-in-children
#5
P G Ragg, G Cahoon, A Yeo, G Chalkiadis
The Coolsense® device is a topical applicator that is used to anaesthetise the skin before a painful procedure. It is a handheld device with a temperature-controlled head that acts on application, without chemicals, to cool and anaesthetise the site of injection. This prospective observational audit of 100 children and adolescents aged six to 18 years studied the analgesic efficacy and patient and carer satisfaction rating of the device during intravenous cannulation and complications arising from its use...
March 2017: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/28225152/topical-phenytoin-for-treating-pressure-ulcers
#6
REVIEW
Xiang Yong Hao, Hong Ling Li, He Su, Hui Cai, Tian Kang Guo, Ruifeng Liu, Lei Jiang, Yan Fei Shen
BACKGROUND: Pressure ulcers are common in clinical practice and pose a significant health problem worldwide. Apart from causing suffering to patients, they also result in longer hospital stays and increase the cost of health care. A variety of methods are used for treating pressure ulcers, including pressure relief, patient repositioning, biophysical strategies, nutritional supplementation, debridement, topical negative pressure, and local treatments including dressings, ointments and creams such as bacitracin, silver sulphadiazine, neomycin, and phenytoin...
February 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28196712/ipomoea-pes-caprae-l-r-br-convolvulaceae-as-a-topical-herbal-medicine-to-relieve-pain-and-inflammation-promising-tool-against-effects-due-to-toxin-skin-contact
#7
Cristiane da Silva Barth, Hugo Guilherme Tolentino de Souza, Lilian W Rocha, Gislaine Francieli da Silva, Mariana Ferreira Dos Anjos, Veronica D'Avila Pastor, Tania Mari Belle Bresolin, Angelica Garcia Couto, José Roberto Santin, Nara Lins Meira Quintão
ETHNOPHARMACOLOGICAL RELEVANCE: Ipomoea pes-caprae is known as bayhops, beach morning glory or goat's foot, and in Brazil as salsa-de-praia. Its leaves are used in worldwide folk medicine for the relief of jellyfish-stings symptoms. The literature only reports the anti-inflammatory and neutralizing effects of a nonpolar plant derived, without validating the popular use or exploring the mechanism of action. AIM OF THE STUDY: This study aimed to evaluate and validate the topical effects of a semisolid containing hydroethanolic extract obtained from the aerial parts of I...
February 11, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28158151/efficacy-and-safety-of-0-625-and-1-25-capsaicin-patch-in-peripheral-neuropathic-pain-multi-center-randomized-and-semi-double-blind-controlled-study
#8
Jee-Youn Moon, Pyung-Bok Lee, Yong-Chul Kim, Sang-Chul Lee, Francis S Nahm, Eunjoo Choi
BACKGROUND: Topical capsaicin therapy may be of benefit in providing pain relief in patients with peripheral neuropathy. OBJECTIVES: To investigate the efficacy and safety of 0.625% (50 µg/cm2) and 1.25% (100 µg/cm2) capsaicin patches (CPs) compared to conventional 0.075% capsaicin cream or placebo patches in patients suffering from peripheral neuropathy. STUDY DESIGN: Early Phase II, multi-center, randomized, semi-double-blind, and placebo-controlled clinical trial...
February 2017: Pain Physician
https://www.readbyqxmd.com/read/28121978/a-vibrating-cold-device-to-reduce-pain-in-the-pediatric-emergency-department-a-randomized-clinical-trial
#9
Debra Ann Potts, Katherine Finn Davis, Okan U Elci, Joel A Fein
OBJECTIVE: Pain of intravenous (IV) catheter insertion can be mitigated with appropriate analgesia, thereby avoiding unnecessary distress. Our objective was to compare the self-reported pain of IV catheter insertion in children when using a vibrating cold device (VCD) versus standard of care 4% topical lidocaine cream (TL). METHODS: This was a 2-arm randomized controlled noninferiority trial with a convenience sample of 4- to 18-year-olds requiring nonemergent IV catheter insertion...
January 24, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28101779/randomized-controlled-trial-of-topical-emla-and-vapocoolant-spray-for-reducing-pain-during-wdpt-vaccination
#10
Navratan Kumar Gupta, Amit Upadhyay, Ajeet Kumar Dwivedi, Astha Agarwal, Vijay Jaiswal, Abhishek Singh
BACKGROUND: Intramuscular vaccination is among the most common source of iatrogenic pain in infants. Vapocoolant sprays are rapid-acting alternative to topical anesthetics. They provide transient anesthesia via evaporation induced skin cooling, and reduce pain due to vaccine injection in children and adults. The objective was to compare the synergistic analgesic effect of eutectic mixture of local anesthetics (EMLA) with breastfeeding (EB group) and vapocoolant spay with breastfeeding (VB group) to that of only breastfeeding (BO group) during whole cell diptheria, pertussis and tetanus (wDPT) vaccination...
January 19, 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/28093604/pretreatment-with-5-fluorouracil-cream-enhances-the-efficacy-of-daylight-mediated-photodynamic-therapy-for-actinic-keratosis
#11
Christoffer V Nissen, Ida Marie Heerfordt, Stine R Wiegell, Carsten S Mikkelsen, Hans C Wulf
The efficacy of photodynamic therapy (PDT) with methyl aminolevulinate is reduced when treating actinic keratosis (AK) on the extremities in comparison with the face and scalp. Studies indicate that PDT efficacy can be improved by combining PDT with other treatment modalities. This randomized intra-individual study investigated whether pretreatment with topical 5% 5-fluorouracil (5-FU) enhanced the treatment efficacy of daylight-mediated PDT in 24 patients with AKs on the hands. One hand of each patient was given 7 days of pretreatment with 5-FU twice daily before daylight-PDT, whereas the other hand was treated with daylight-PDT alone...
January 17, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28063969/hii-mesophase-as-a-drug-delivery-system-for-topical-application-of-methyl-salicylate
#12
Xin Liang, Yu-Lin Chen, Xiao-Jing Jiang, Sheng-Mei Wang, Ji-Wen Zhang, Shuang-Ying Gui
The main objective of this study was to develop reversed hexagonal (HII) mesophase for transdermal delivery of methyl salicylate. The formulation was prepared, characterized and evaluated for its skin penetration in vitro and skin retention in vivo. Preliminary pharmacodynamics and skin irritation were also investigated. The formulation was identified as hexagonal structure. In vitro study exhibited that HII mesophase enhanced the skin permeation by delivering 2.61 times more methyl salicylate than the commercially available cream...
March 30, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28031725/skin-matters-the-role-of-keratinocytes-in-nociception-a-rational-argument-for-the-development-of-topical-analgesics
#13
REVIEW
Jan M Keppel Hesselink, David J Kopsky, Arun K Bhaskar
Treatment of neuropathic pain using topical formulations is still in its infancy. Only few topical analgesic formulations have become available for clinical use, and among these, analgesic creams are still rare. This is unfortunate because analgesic creams offer a number of advantages over patches, such as convenience, ease of adapting the frequency of application, and dose, and "rubbing cream where it hurts" involves the patient much more in the therapeutic process compared to patches and other localized treatment modalities...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28008281/nicoboxil-nonivamide-cream-effectively-and-safely-reduces-acute-nonspecific-low-back-pain-a-randomized-placebo-controlled-trial
#14
Zuzana Blahova, Janina Claudia Holm, Thomas Weiser, Erika Richter, Matthias Trampisch, Elena Akarachkova
BACKGROUND/OBJECTIVE: Low back pain affects many patients and has a high socioeconomic impact. Topical capsaicinoids have been used for decades to treat musculoskeletal pain. This study investigated the effects of the fixed dose combination (FDC) of nonivamide (a capsaicinoid) and nicoboxil (a nicotinic acid ester) cream in the treatment of acute nonspecific low back pain. MATERIALS AND METHODS: This phase III randomized, double-blind, placebo-controlled, multinational, multi-center trial investigated efficacy, safety, and tolerability of topical nicoboxil 1...
2016: Journal of Pain Research
https://www.readbyqxmd.com/read/28000146/cannabinoid-hyperemesis-syndrome-diagnosis-pathophysiology-and-treatment-a-systematic-review
#15
REVIEW
Cecilia J Sorensen, Kristen DeSanto, Laura Borgelt, Kristina T Phillips, Andrew A Monte
Cannabinoid hyperemesis syndrome (CHS) is a syndrome of cyclic vomiting associated with cannabis use. Our objective is to summarize the available evidence on CHS diagnosis, pathophysiology, and treatment. We performed a systematic review using MEDLINE, Ovid MEDLINE, Embase, Web of Science, and the Cochrane Library from January 2000 through September 24, 2015. Articles eligible for inclusion were evaluated using the Grading and Recommendations Assessment, Development, and Evaluation (GRADE) criteria. Data were abstracted from the articles and case reports and were combined in a cumulative synthesis...
March 2017: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/27956393/relative-effectiveness-of-additive-pain-interventions-during-vaccination-in-infants
#16
Anna Taddio, Rebecca Pillai Riddell, Moshe Ipp, Steven Moss, Stephen Baker, Jonathan Tolkin, Dave Malini, Sharmeen Feerasta, Preeya Govan, Emma Fletcher, Horace Wong, Caitlin McNair, Priyanjali Mithal, Derek Stephens
BACKGROUND: Vaccine injections can cause acute pain and distress in infants, which can contribute to dissatisfaction with the vaccination experience and vaccine hesitancy. We sought to compare the effectiveness of additive pain interventions administered consistently during vaccine injections in the first year of life. METHODS: We conducted a multicentre, longitudinal, double-blind, add-on, randomized controlled trial. Healthy infants were randomly assigned to 1 of 4 levels of pain management for all vaccine injections at 2, 4, 6 and 12 months: (i) placebo control; (ii) parent-directed video education about infant soothing; (iii) the video plus sucrose administered orally or (iv) the video plus sucrose plus liposomal lidocaine applied topically...
February 13, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/27888448/a-randomized-single-blind-trial-of-clobetasol-propionate-0-05-cream-under-silicone-dressing-occlusion-versus-intra-lesional-triamcinolone-for-treatment-of-keloid
#17
Norazirah Md Nor, Rasimah Ismail, Adawiyah Jamil, Shamsul Azhar Shah, Farah Hani Imran
BACKGROUND AND OBJECTIVE: Keloid is conventionally treated with intra-lesional (IL) triamcinolone, which is highly operator dependent and has its own adverse effects. Topical steroid and silicone dressings are a patient friendly and non-invasive treatment alternative. We therefore sought to determine the efficacy and safety of topical clobetasol propionate (Dermovate(®)) 0.05% cream under occlusion with Mepiform(®) silicone dressing compared to IL triamcinolone in the treatment of keloid...
November 25, 2016: Clinical Drug Investigation
https://www.readbyqxmd.com/read/27869649/randomized-trial-of-calcipotriol-combined-with-5-fluorouracil-for-skin-cancer-precursor-immunotherapy
#18
Trevor J Cunningham, Mary Tabacchi, Jean-Pierre Eliane, Sara Moradi Tuchayi, Sindhu Manivasagam, Hengameh Mirzaalian, Ahu Turkoz, Raphael Kopan, Andras Schaffer, Arturo P Saavedra, Michael Wallendorf, Lynn A Cornelius, Shadmehr Demehri
BACKGROUND: Actinic keratosis is a precursor to cutaneous squamous cell carcinoma. Long treatment durations and severe side effects have limited the efficacy of current actinic keratosis treatments. Thymic stromal lymphopoietin (TSLP) is an epithelium-derived cytokine that induces a robust antitumor immunity in barrier-defective skin. Here, we investigated the efficacy of calcipotriol, a topical TSLP inducer, in combination with 5-fluorouracil (5-FU) as an immunotherapy for actinic keratosis...
January 3, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27828835/prospective-evaluation-of-fractional-co2-laser-treatment-of-mature-burn-scars
#19
Sigrid Blome-Eberwein, Christina Gogal, Michael J Weiss, Deborah Boorse, Patrick Pagella
The authors conducted a prospective study of fractional CO2 laser treatment of mature burn scars, comparing objective and subjective scar measurements evaluating at least one treatment and one control scar on the same patient pre- and post treatments. After institutional review board approval, burn survivors with mature blatant burn scars were invited to enter the study. A series of three fractional CO2 laser treatments was performed in an office setting, using topical anesthetic cream, at 40 to 90 mJ, 100 to 150 spots per cm...
November 2016: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/27803240/self-administered-interventions-for-anogenital-warts-in-immunocompetent-patients-a-systematic-review-and-meta-analysis
#20
Ricardo Niklas Werner, Lukas Westfechtel, Corinna Dressler, Alexander Nast
BACKGROUND: Anogenital warts (AGWs, condylomata acuminata) are among the most common STIs and may severely impact quality of life (QoL). Available treatment options are characterised by a high proportion of non-responders and recurrences. OBJECTIVE: To systematically review and meta-analyse the available evidence from randomised controlled trials (RCTs) on topical treatments for AGWs considering short-term and long-term efficacy, effects on QoL and adverse events (AE)...
November 1, 2016: Sexually Transmitted Infections
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