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bronchiolitis, ALTE

Kentigern Thorburn, Crawford Fulton, Charlotte King, Difijah Ramaneswaran, Abdulaziz Alammar, Paul S McNamara
Bronchiolitis, often caused by respiratory syncytial virus (RSV), is the commonest cause of hospitalisation in infancy. Serum transaminases are sometimes raised in children with bronchiolitis. We tested the hypothesis that raised transaminases are associated with increased disease severity in children ventilated for bronchiolitis. Prospective observational cohort study of mechanically ventilated children with community-acquired RSV bronchiolitis. Alanine transaminase (ALT) and aspartate transaminase (AST) levels were measured daily...
January 29, 2018: Scientific Reports
Claire Stock, Georges Teyssier, Vincent Pichot, Philippe Goffaux, Jean-Claude Barthelemy, Hugues Patural
BACKGROUND: Apparent life-threatening events (ALTE) and/or prolonged apnoea have been well-documented during respiratory syncytial virus (RSV) infection in infants less than 2 months of age but fundamental mechanisms remain unclear. The possibility of a central origin for the development of severe cardiac and respiratory events encouraged us, to explore the autonomic nervous system (ANS) profile of infected infants, since ANS activity may contribute to the constellation of symptoms observed during severe forms of RSV bronchiolitis...
August 25, 2010: Autonomic Neuroscience: Basic & Clinical
Edward Yang, Talissa Altes, Sudha A Anupindi
Mycoplasma pneumoniae is a major cause of community-acquired pneumonia. Because most children are not imaged prior to onset of clinical symptoms, the appearance of early Mycoplasma infection has not been extensively studied. We present the case of an 11-year-old boy with large pulmonary masses incidentally detected during spine MRI evaluation for scoliosis. Eight days later, the patient developed acute respiratory symptoms, and the masses seen previously had evolved into a diffuse bronchiolitis. Diagnostic testing identified Mycoplasma pneumoniae as the likely etiology...
April 2008: Pediatric Radiology
Dattesh D Shanbhag, Talissa A Altes, G Wilson Miller, Jaime F Mata, Jack Knight-Scott
PURPOSE: To examine the utility of a (3)He spectroscopic q-space technique for detecting changes in lung morphometry in vivo. MATERIALS AND METHODS: A diffusion-weighted spectroscopy sequence was used to collect global diffusion data from healthy adults (N = 11), healthy children (N = 5), and chronic obstructive pulmonary disease (COPD) patients (N = 2) using 40 cc of hyperpolarized (3)He gas within a two second breathhold. Displacement probability profiles (DPP) were obtained by Fourier transformation of diffusion data with respect to q...
July 2006: Journal of Magnetic Resonance Imaging: JMRI
Talissa A Altes, Michael Salerno
Hyperpolarized gases belong to a new class of MR contrast agents that, when inhaled, provide high temporal and spatial resolution images of the lung airspaces. At this time, hyperpolarized gas MRI is only being performed at a limited number of institutions. However, the availability of hyperpolarized gas MRI could increase dramatically in coming years as regulatory hurdles within the U.S. are surmounted. The intent of this paper is to provide an introduction to hyperpolarized gas MRI for the thoracic radiologist...
October 2004: Journal of Thoracic Imaging
Maree Gleeson, Robert L Clancy, Amanda J Cox, Sally A Gulliver, Sharron T Hall, David M Cooper
This study examined the hypothesis that dysregulation of mucosal immune responses to respiratory infections is a critical event, which could be causal in respiratory arrest of some previously healthy infants. To examine this hypothesis, a prospective study was undertaken of infants presenting to the emergency department of a major teaching hospital with acute life threatening events (ALTE) of unknown cause and classified as "near-miss" SIDS. Salivary immunoglobulin concentrations were measured on admission and again after 14 days...
September 1, 2004: FEMS Immunology and Medical Microbiology
Michael Eisenhut, Kentigern Thorburn, Tageldin Ahmed
OBJECTIVES: To compare disease severity as judged by duration of ventilation, inotrope use and mortality in children ventilated for respiratory syncytial virus (RSV)-positive lower respiratory tract infection (LRTI) with and without elevated transaminase levels and to determine the aetiology of elevated transaminase levels in this patient group. DESIGN: Prospective observational study. SETTING: Twenty-two-bed Paediatric Intensive Care Unit...
May 2004: Intensive Care Medicine
Albert Altès, Jorge Sierra, Jordi Esteve, Gregorio Martín-Henao, Pedro Marín, Anna Sureda, Javier Briones, Rodrigo Martino, Neus Villamor, Dolors Colomer, Enric Carreras, J Garcia, Salut Brunet, Emili Montserrat
OBJECTIVE: The main objective of this work was to decrease the incidence of relapse after autologous stem cell transplantation with a "double purging" procedure. METHODS: We used a "positive" (CD34) and "negative" (CD19) double selection method to improve the efficacy of "single purging" of hematopoietic harvests in poor-prognosis lymphoproliferative disorders. All patients included in the study had a positive molecular marker of their disease. Minimal residual disease (MRD) was studied by flow cytometry and PCR techniques during the purging procedure and after transplantation...
July 2002: Experimental Hematology
S L Born, A S Fix, D Caudill, L D Lehman-McKeeman
Coumarin is a known hepatotoxicant in laboratory animals, particularly rats. However, the mouse lung was identified as a major target organ in a chronic bioassay, with an oral gavage dosage of 200 mg/kg coumarin increasing the incidence of alveolar/bronchiolar adenomas and carcinomas. The purpose of the present work was to determine whether coumarin was acutely toxic in the mouse and rat lung. Male and female B6C3F1 mice were dosed orally by gavage with coumarin at 0, 10, 20, 50, 100, 150, and 200 mg/kg and lung toxicity was determined 24 h later by histological evaluation...
July 1998: Toxicology and Applied Pharmacology
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