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Cartilage repair

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https://www.readbyqxmd.com/read/28345610/early-loss-of-subchondral-bone-following-microfracture-is-counteracted-by-bone-marrow-aspirate-in-a-translational-model-of-osteochondral-repair
#1
Liang Gao, Patrick Orth, Kathrin Müller-Brandt, Lars K H Goebel, Magali Cucchiarini, Henning Madry
Microfracture of cartilage defects may induce alterations of the subchondral bone in the mid- and long-term, yet very little is known about their onset. Possibly, these changes may be avoided by an enhanced microfracture technique with additional application of bone marrow aspirate. In this study, full-thickness chondral defects in the knee joints of minipigs were either treated with (1) debridement down to the subchondral bone plate alone, (2) debridement with microfracture, or (3) microfracture with additional application of bone marrow aspirate...
March 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28345408/autologous-chondrocyte-implantation-to-isolated-patella-cartilage-defects
#2
Arvind von Keudell, Roger Han, Tim Bryant, Tom Minas
Background Autologous chondrocyte implantation (ACI) is a durable treatment for patients with chondral defects. This study presents the comprehensive evaluation of patients with patella defects treated with ACI at medium- to long-term follow-up. Methods Thirty consecutive patients with isolated chondral lesions of the patella were enrolled prospectively. Primary outcome measures were validated patient reported outcome measures and objective magnetic resonance imaging. Results Nineteen of 30 patients underwent tibial tubercle osteotomy (TTO) to correct lateral maltracking in combination with soft tissue balancing...
April 2017: Cartilage
https://www.readbyqxmd.com/read/28344902/isolation-and-characterization-of-human-articular-chondrocytes-from-surgical-waste-after-total-knee-arthroplasty-tka
#3
Jakob Naranda, Lidija Gradišnik, Mario Gorenjak, Matjaž Vogrin, Uroš Maver
BACKGROUND: Cartilage tissue engineering is a fast-evolving field of biomedical engineering, in which the chondrocytes represent the most commonly used cell type. Since research in tissue engineering always consumes a lot of cells, simple and cheap isolation methods could form a powerful basis to boost such studies and enable their faster progress to the clinics. Isolated chondrocytes can be used for autologous chondrocyte implantation in cartilage repair, and are the base for valuable models to investigate cartilage phenotype preservation, as well as enable studies of molecular features, nature and scales of cellular responses to alterations in the cartilage tissue...
2017: PeerJ
https://www.readbyqxmd.com/read/28344539/scaphocapitate-syndrome-with-associated-trans-scaphoid-trans-hamate-perilunate-dislocation-a-case-report-and-description-of-surgical-fixation
#4
Fiesky A Nunez, T David Luo, Jesse B Jupiter, Fiesky A Nunez
Background: Perilunate fracture dislocations are often associated with fractures of the distal pole of the scaphoid or the proximal pole of the capitate. However, the combination of perilunate dislocation with multiple carpal fractures and associated scaphocapitate syndrome is very rare. Methods: We report a unique case of scaphocapitate fracture syndrome with perilunate dislocation and fracture of the hamate resulting from a high-energy injury to the wrist during a dirt-bike competition. Results: Open reduction and internal fixation of the scaphoid fracture with a 3...
March 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28338178/the-involvement-of-senescence-induced-by-the-telomere-shortness-in-the-decline-of-osteogenic-differentiation-in-bmscs
#5
C Li, G-J Wei, L Xu, J-S Rong, S-Q Tao, Y-S Wang
OBJECTIVE: BMSC (Bone marrow mesenchymal stem cells) is an important seed cell for the repair of bone and cartilage defect in the tissue engineering. The proliferation rate and differentiation capacity of BMSCs from the old donors were less than that from young donors; however, the related mechanism remained unclear. MATERIALS AND METHODS: Sprague Dawley (SD) rats BMSCs were cultured and treated. Hydrogen peroxide (H2O2) and continual passage of BMSCs were performed to induce senescence...
March 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28333779/impact-of-chronic-suppurative-otitis-media-in-pediatric-cochlear-implant-recipients-insight-into-the-challenges-from-a-tertiary-referral-center-in-uk
#6
Paramita Baruah, Kate Hanvey, Richard Irving, Konstance Tzifa
OBJECTIVE: Analyze the presentation and evolution of chronic suppurative otitis media (CSOM) in children with cochlear implants (CI) and explore the merit of early intervention. STUDY DESIGN: Retrospective patient review. SETTING: Tertiary referral hospital and cochlear implant programme. PATIENTS: Children with a CI who developed CSOM. INTERVENTION: Tympanoplasty. MAIN OUTCOME MEASURES: Disease control, recurrence of cholesteatoma, cochlear implant preservation...
March 22, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28333539/age-is-not-a-contraindication-for-cartilage-surgery-a-critical-analysis-of-standardized-outcomes-at-long-term-follow-up
#7
Giuseppe Filardo, Luca Andriolo, Andrea Sessa, Francesca Vannini, Alberto Ferruzzi, Maurilio Marcacci, Elizaveta Kon
BACKGROUND: Age is commonly accepted as a negative prognostic factor in cartilage surgery, and cutoff values of 30 to 40 years have been previously suggested as treatment indication. However, the lower outcome scores documented in older patients do not take in consideration the decreasing requirements of an aging joint. PURPOSE: To analyze the real effect of age in terms of recovery with respect to the functional level expected for different age categories of patients treated for cartilage lesions...
March 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28332587/bioreactor-mechanically-guided-3d-mesenchymal-stem-cell-chondrogenesis-using-a-biocompatible-novel-thermo-reversible-methylcellulose-based-hydrogel
#8
A Cochis, S Grad, M J Stoddart, S Farè, L Altomare, B Azzimonti, M Alini, L Rimondini
Autologous chondrocyte implantation for cartilage repair represents a challenge because strongly limited by chondrocytes' poor expansion capacity in vitro. Mesenchymal stem cells (MSCs) can differentiate into chondrocytes, while mechanical loading has been proposed as alternative strategy to induce chondrogenesis excluding the use of exogenous factors. Moreover, MSC supporting material selection is fundamental to allow for an active interaction with cells. Here, we tested a novel thermo-reversible hydrogel composed of 8% w/v methylcellulose (MC) in a 0...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28330431/fabrication-and-characterization-of-biphasic-silk-fibroin-scaffolds-for-tendon-ligament-to-bone-tissue-engineering
#9
Sònia Font Tellado, Walter Bonani, Elizabeth Rosado Balmayor, Peter Föhr, Antonella Motta, Claudio Migliaresi, Martijn van Griensven
Tissue engineering is an attractive strategy for tendon/ligament-to-bone interface repair. The structure and extracellular matrix composition of the interface are complex and allow for a gradual mechanical stress transfer between tendons/ligaments and bone. Thus, scaffolds mimicking the structural features of the native interface may be able to better support functional tissue regeneration. In this study, we fabricated biphasic silk fibroin scaffolds designed to mimic the gradient in collagen molecule alignment present at the interface...
March 23, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28325693/surgical-technique-and-clinical-outcomes-of-retrograde-osteochondral-autograft-transfer-for-osteochondral-lesions-of-the-tibial-plateau
#10
Hiromitsu Yabumoto, Yasuaki Nakagawa, Shogo Mukai, Takahiko Saji, Takashi Nakamura
PURPOSE: To present the surgical technique, clinical outcomes, and poor prognostic factors of arthroscopic retrograde osteochondral autograft transfer of the tibial plateau. METHODS: Twelve patients (6 men, 6 women; mean age, 38.7 years) with tibial plateau osteochondral lesions underwent surgery. The primary diseases were osteonecrosis in 4 cases, cartilage injuries in 6, and postfractures of the tibial plateau in 2. Clinical outcomes were evaluated preoperatively and postoperatively according to the International Knee Documentation Committee score and the Japanese Orthopaedic Association score...
March 18, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28325151/adipose-tissue-derived-pericytes-for-cartilage-tissue-engineering
#11
Jin Xin Zhang, Chun Yan Du, Wei Min Guo, Pan Li, Shu Yun Liu, Zhi Guo Yuan, Jian Hua Yang, Xun Sun, He Yong Yin, Quan Yi Guo, Chen Fu Zhou
Mesenchymal stem cells (MSCs) represent a promising alternative source for cartilage tissue engineering. However, MSC culture is labor-intensive, so these cells cannot be applied immediately to regenerate cartilage for clinical purposes. Risks during the ex vivo expansion of MSCs, such as infection and immunogenicity, can be a bottleneck in their use in clinical tissue engineering. As a novel stem cell source, pericytes are generally considered to be the origin of MSCs. Pericytes do not have to undergo time-consuming ex vivo expansion because they are uncultured cells...
March 21, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28324152/good-clinical-results-with-autologous-matrix-induced-chondrogenesis-amic-technique-in-large-knee-chondral-defects
#12
Alfredo Schiavone Panni, Chiara Del Regno, Giuseppe Mazzitelli, Rocco D'Apolito, Katia Corona, Michele Vasso
PURPOSE: Autologous matrix-induced chondrogenesis (AMIC) is a treatment for focal full-thickness cartilage defects combining microfracturing with an exogenous I/III collagen matrix (Chondro-Gide). The aim of the present study was to determine the 7 years outcomes of patients treated with the AMIC technique for knee chondral defects larger than 2 cm(2). The hypothesis was that the positive short-term outcomes achieved in the previous series would not deteriorate at a 7-year follow-up...
March 21, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28321429/intermediate-to-long-term-results-of-combined-anterior-cruciate-ligament-reconstruction-and-autologous-chondrocyte-implantation
#13
Andrew N Pike, Tim Bryant, Takahiro Ogura, Tom Minas
BACKGROUND: Cartilage injury associated with anterior cruciate ligament (ACL) ruptures is common; however, relatively few reports exist on concurrent cartilage repair with ACL reconstruction. Autologous chondrocyte implantation (ACI) has been utilized successfully for treatment of moderate to large chondral defects. HYPOTHESIS: ACL insufficiency with relatively large chondral defects may be effectively managed with concurrent ACL reconstruction and ACI. STUDY DESIGN: Case series; Level of evidence, 4...
February 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28319418/autologous-cartilage-chip-transplantation-improves-repair-tissue-composition-compared-with-marrow-stimulation
#14
Bjørn Borsøe Christensen, Morten Lykke Olesen, Martin Lind, Casper Bindzus Foldager
BACKGROUND: Repair of chondral injuries by use of cartilage chips has recently demonstrated clinical feasibility. PURPOSE: To investigate in vivo cartilage repair outcome of autologous cartilage chips compared with marrow stimulation in full-thickness cartilage defects in a minipig model. STUDY DESIGN: Controlled laboratory study. METHODS: Six Göttingen minipigs received two 6-mm chondral defects in the medial and lateral trochlea of each knee...
March 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28318324/subchondral-bone-response-to-injected-adipose-derived-stromal-cells-for-treating-osteoarthritis-using-an-experimental-rabbit-model
#15
A Parrilli, G Giavaresi, A Ferrari, F Salamanna, G Desando, B Grigolo, L Martini, M Fini
Although articular cartilage is the target of osteoarthritis (OA), its deterioration is not always clearly associated with patient symptoms. Because a functional interaction between cartilage and bone is crucial, the pathophysiology of OA and its treatment strategy must focus also on subchondral bone. We investigated whether adipose-derived stromal cells (ASCs) injected into a joint at two different concentrations could prevent subchondral bone damage after the onset of mild OA in a rabbit model. We measured both volumetric and densitometric aspects of bone remodeling...
March 20, 2017: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/28318168/-research-progress-of-mechanism-of-hypoxia-inducible-factor-1%C3%AE-signaling-pathway-in-condylar-cartilage-growth-and-remodeling
#16
Xu Gaoli, Wu Lili, Wu Zhiwu, Gu Zhiyuan
The condylar cartilage was adapted to hypoxic conditions in vivo. However, condylar cartilage cells exposed in normoxia in vitro affect the chondrocyte phenotype and cartilage matrix formation. This condition also resulted in great difficulty in chondrocyte research. Culturing chondrocyte should be simulated in in vivo hypoxia environment as much as possible. The hypoxia-inducible factor-1α (HIF-1α) demonstrates an important transcription factor of adaptive response to hypoxic conditions. HIF-1α also plays an active role in maintaining homeostasis and function of chondrocytes...
December 1, 2016: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28302318/regional-differences-of-tibial-and-femoral-cartilage-in-the-chondrocyte-gene-expression-immunhistochemistry-and-composite-in-different-stages-of-osteoarthritis
#17
A Lahm, D Dabravolski, H Spank, H Merk, J Esser, R Kasch
The function of articular cartilage as an avascular tissue is mainly served by collagen type II and proteoglycan molecules. Within this matrix homeostasis between production and breakdown of the matrix is exceptionally sensitive. The current study was conducted to identify regional differences in specific alterations in cartilage composition during the osteoarthritic process of the human knee joint. Therefor the changes in the expression of the key molecules of the extracellular matrix were measured in dependence of the anatomical side (femoral vs tibial) and associated with immunohistochemistry and quantitative measurement...
February 24, 2017: Tissue & Cell
https://www.readbyqxmd.com/read/28301627/single-staged-tunneled-cheek-interpolation-flap-with-cartilage-batten-graft-for-repair-of-nasal-ala-defect
#18
Tatyana A Petukhova, Jayne S Joo, Daniel B Eisen
<p>Surgical defects located within 5 mm of the nasal alar margin are at risk for alar elevation or collapse of the external nasal valve during wound healing. To reduce the chance of such complications, free cartilage grafts may be used as part of the reconstruction. However, if the defect is large enough so that the free cartilage graft does not fill most of the defect, wound contraction can still lead to alar displacement. In these situations, skin may need to be recruited from either the forehead or cheek in the form of an interpolation flap to cover both the free cartilage graft and the residual cutaneous defect...
March 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28300491/dynamic-regulation-of-twist1-expression-during-chondrogenic-differentiation-of-human-bone-marrow-derived-mesenchymal-stem-cells
#19
Mairéad A Cleary, Roberto Narcisi, Anna Albiero, Florien Jenner, Laurie M G de Kroon, Wendy J L M Koevoet, Pieter A J Brama, Gerjo J V M van Osch
Human bone marrow-derived mesenchymal stem cells (BMSCs) are clinically promising to repair damaged articular cartilage. This study investigated TWIST1, an important transcriptional regulator in mesenchymal lineages, in BMSC chondrogenesis. We hypothesized that downregulation of TWIST1 expression is required for in vitro chondrogenic differentiation. Indeed, significant downregulation of TWIST1 was observed in murine skeletal progenitor cells during limb development (N = 3 embryos), and during chondrogenic differentiation of culture-expanded human articular chondrocytes (N = 3 donors) and isolated adult human BMSCs (N = 7 donors), consistent with an inhibitory effect of TWIST1 expression on chondrogenic differentiation...
March 16, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/28300264/integration-of-stem-cell-derived-exosomes-with-in-situ-hydrogel-glue-as-a-promising-tissue-patch-for-articular-cartilage-regeneration
#20
Xiaolin Liu, Yunlong Yang, Yan Li, Xin Niu, Bizeng Zhao, Yang Wang, Chunyan Bao, Zongping Xie, Qiuning Lin, Linyong Zhu
The regeneration of articular cartilage, which scarcely shows innate self-healing ability, is a great challenge in clinical treatment. Stem cell-derived exosomes (SC-Exos), an important type of extracellular nanovesicle, exhibit great potential for cartilage regeneration to replace stem cell-based therapy. Cartilage regeneration often takes a relatively long time and there is currently no effective administration method to durably retain exosomes at cartilage defect sites to effectively exert their reparative effect...
March 16, 2017: Nanoscale
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