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Seminars in neurology

Nicoline Schiess, Peter A Calabresi
It is estimated that there are 300,000 people with multiple sclerosis (MS) in the United States and 2.3 million worldwide. Each MS attack can affect function in cognitive, emotional, motoric, sensory, or visual domains. Patients are often struck in the prime of their lives as they attempt to move forward with career, and family. Since the previous 2010 Seminars in Neurology Pearls and Pitfalls issue, the world of MS has drastically changed and advanced. Here the authors address the ever-changing MS world in both treatment options and diagnostics, covering easily missed differential diagnoses, newly available immunomodulatory therapy, and the challenges of safely treating patients...
August 2016: Seminars in Neurology
Jamie I D Campbell
No abstract text is available yet for this article.
March 2016: Canadian Journal of Experimental Psychology, Revue Canadienne de Psychologie Expérimentale
Lorraine V Kalia, Anthony E Lang
Parkinson's disease is a neurological disorder with evolving layers of complexity. It has long been characterised by the classical motor features of parkinsonism associated with Lewy bodies and loss of dopaminergic neurons in the substantia nigra. However, the symptomatology of Parkinson's disease is now recognised as heterogeneous, with clinically significant non-motor features. Similarly, its pathology involves extensive regions of the nervous system, various neurotransmitters, and protein aggregates other than just Lewy bodies...
August 29, 2015: Lancet
M Khare, Av Singh, P Zamboni
Multiple sclerosis (MS) is an autoimmune neurological disorder, which has impacted health related quality of life (HRQoL) more intensively than any other neurological disorder. The approaches to improve the health standard in MS patient are still a subject of primary importance in medical practice and seek a lot of experimental exploration. The present review briefly explains the anomaly in neuron anatomy and dysfunction in signal transmission arising in the context with the chronic cerebrospinal venous insufficiency (CCSVI), a recent hypothesis related with MS pathophysiology...
May 2014: Annals of Medical and Health Sciences Research
John C Steele
Parkinsonism recalls James Parkinson of London and his description of six patients with "paralysis agitans" in 1817, which neurologist Jean-Marie Charcot renamed Parkinson disease. Its variants, referred to as atypical parkinsonian disorders, are the subject of this issue of Seminars in Neurology through which we continue a journey toward understanding the pathogenesis of these diverse neurodegenerative diseases that are sometimes genetically determined, but are more often sporadic and without familial occurrence...
April 2014: Seminars in Neurology
Toshio Fukutake, Yoichiro Hashimoto, Takayuki Taniwaki, Itaru Toyoshima, Takahiro Amano, Masashi Aoki, Fumihito Yoshii, Takashi Inuzuka, Jun-ichi Kira
To evaluate postgraduate neurological education, a questionnaire-based survey regarding junior and senior doctor-in-training and the Board Certification Examination in Neurology was carried out on the training supervisors of 690 insitutes, excluding 80 university hospitals. The institutes included 243 teaching hospitals, 326 semi-teaching hospitals and 121 education-associated institutes authorized by the Japanese Society of Neurology (JSN). The results were obtained from 388 institutes, and the response rate was 56...
2014: Rinshō Shinkeigaku, Clinical Neurology
Marco T Medina
The World Federation of Neurology (WFN) lost an outstanding leader on November 22, 2013 with the death of Professor Theodore Leon Munsat ("Ted"), in Waltham, Massachusetts, USA. Professor Munsat was Emeritus professor of Neurology at Tufts University School of Medicine and served the WFN in several capacities as trustee, chairman of the WFN Education and research committees, chairman of the WFN ALS Research group and founding director of the WFN Seminars in Clinical Neurology. He was president of the American Academy of Neurology (AAN), 1989-1991, chairman of the Continuing Educational Committee of the AAN and founding director of AAN's premier continuing medical education journal Continuum: Lifelong Learning in Neurology...
April 15, 2014: Journal of the Neurological Sciences
Fadi Abou-Mrad, Lubna Tarabey
Quality of health care is largely dependent on a holistic approach to human person (HP). In Lebanon, the medical field, including neurology, seems to be ignorant to the integrity of the human person. The objective of this study is to provide an insight to the importance of reintegrating the HP in the medical field attempting to offer a basis for scientists interested in carrying out similar research in face of the complete lack of studies in Lebanon. This requires the contribution of various health care support systems to bring the topic into public dialogue allowing for a reassessment of the issue...
February 2014: Neurological Sciences
R A Purdy
The future prospects that we can expect in migraine management are both exciting and challenging. Obviously, the future cannot be predicted fully; however, the science related to migraine pathogenesis, diagnosis and treatment has increased exponentially over the past two decades and continues to direct future research and clinical care. More than any time in the recent past, it now may be more possible to define better what migraine is and how it relates to other neurological disorders and other diseases. This overview will look at future prospects for management of migraine and how they relate to the migraine diathesis, and ways that might provide a better understanding of how it might be possible to calm the excitable brain...
May 2013: Neurological Sciences
Yoshihiro Arakawa
At the University of Tokyo Hospital, investigator-driven clinical development of novel drugs and medical devices is mainly supported by the Translational Research Center and Clinical Research Support Center. The former supports non-clinical research and the preparation of test materials and the latter supports clinical trials. The Clinical Research Support Center was established in 2010 by the reorganization of the former Clinical Research Center, which was established in 2001. The center adopted International Conference on Harmonisation-Good Clinical Practice (ICH-GCP) as a standard guideline for clinical trials and prepared standard operation procedures and templates for protocols and informed consent documents in 2001 and, thereafter, provided consultation services to researchers for protocol development...
2013: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
Francesca Attanasio, Serena Granziera, Valter Giantin, Enzo Manzato
CONTEXT: Morgagni-Stewart-Morel syndrome is defined as the presence of hyperostosis frontalis interna, variably associated with metabolic, endocrine, and neuropsychiatric disorders. The possible cause-effect relationship of these associations remains uncertain. CASE PRESENTATION: A 75-year-old woman presented with severe frontal headache and a history of psychotic disorders. On instrumental examination she was found to have extensive frontal hyperostosis and cortical atrophy...
February 2013: Journal of Clinical Endocrinology and Metabolism
Nobuo Kohara
All neurologists have to make a differential diagnosis of consciousness loss by EEG. The judgment of epilepsy is especially important. Experts of neurology were also required to determine the level and etiology of the acute or chronic weakness or numbness by EMG with nerve conduction study. Hands on seminar and e-learning would be useful to acquire these tools.
2012: Rinshō Shinkeigaku, Clinical Neurology
Kathryn N North
In this issue of Seminars in Pediatric Neurology, each chapter will focus on the features and management of individual congenital myopathies. This introductory chapter will provide an overview of the clinical features that alert the clinician to the likely diagnosis of a congenital myopathy, and specific features on history and examination that are characteristic of a specific genetic subtype. Most congenital myopathies share a common pattern of clinical features, which makes it difficult to predict the genetic cause in a patient by clinical assessment alone...
December 2011: Seminars in Pediatric Neurology
Robert Li Kitts, Joanna Christodoulou, Stuart Goldman
OBJECTIVE: Professional siloing within medical institutions has been identified as a problem in medical education, including resident training. The authors discuss how trainees from different disciplines can collaborate to address this problem. METHOD: A group of trainees from psychiatry, developmental medicine, neurology, and education came together to develop a community of practice (CoP) to promote interdisciplinary collaboration. RESULTS: A key outcome was the development of a seminar including speakers and attendees (N=20 to 35) from psychiatry, developmental medicine, neurology, and education...
2011: Academic Psychiatry
Virmarie Correa-Fernández, Marivel Davila, Samira A Kamrudin, Dennis H Li, Syed W Noor, Abiodun O Oluyomi, Shine Chang, Carrie Cameron
To increase the adoption of transdisciplinary research methods among future cancer prevention investigators, faculty members from The University of Texas MD Anderson Cancer Center developed a graduate-level course in biobehavioral methods in cancer prevention research. Two instructors paired by topic and area of expertise offered an hour-long lecture-based seminar every week for 15 weeks during the spring semester of 2010. Students and presenters both evaluated the overall course content and delivery method, as well as each session...
December 2011: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
Clive Ballard, Serge Gauthier, Anne Corbett, Carol Brayne, Dag Aarsland, Emma Jones
An estimated 24 million people worldwide have dementia, the majority of whom are thought to have Alzheimer's disease. Thus, Alzheimer's disease represents a major public health concern and has been identified as a research priority. Although there are licensed treatments that can alleviate symptoms of Alzheimer's disease, there is a pressing need to improve our understanding of pathogenesis to enable development of disease-modifying treatments. Methods for improving diagnosis are also moving forward, but a better consensus is needed for development of a panel of biological and neuroimaging biomarkers that support clinical diagnosis...
March 19, 2011: Lancet
Christina Mills
When Cuba was hit by a neuropathy epidemic two decades ago, Dr Rosaralis Santiesteban was one of the Cuban health professionals who played a key role in its management, as reflected in a recent issue of Seminars in Ophthalmology. She was well prepared for her part: trained in medicine at the University of Havana before completing a residency in ophthalmology and eventually a doctorate in medical sciences, she has received multiple honors for her research, publishing and teaching. In 2007, she was named Distinguished Researcher by the Cuban Ministry of Science, Technology and the Environment...
January 2011: MEDICC Review
Michael James Gilhooley
The following essay provides a summary of a seminar given on the sixth of November, 2010 at the combined annual congress, held at Brussels of the Centro Studi Psichatrici Vrije Universiteit Brussel, Université Catholique de Louvain & the Bedfordshire Centre for Mental Health Research. The talk aimed to present a brief taster, assuming no prior knowledge, of adult neurogenesis, the formation of new nerve cells, in relation to the aetiology and treatment of depression. The talk begins with an introduction to the principles of adult neurogenesis: from initial investigations by Ramon y Cajal in the 19th century, resulting in a "static brain hypothesis", to their subsequent challenge almost one hundred years later...
November 2010: Psychiatria Danubina
Matthew Grantz
Peripheral neuropathy is common with many different etiologies. This is the second of three articles to review the less-common causes of peripheral neuropathy. Part II reviews the intrinsic "reactive" causes of peripheral neuropathy, including those related to connective tissue, vasculitis, sarcoid, organ failure, and inflammatory bowel disease. The extrinsic causes of neuropathy and the induced or inherited causes of neuropathy are covered in separate articles in this issue of SEMINARS IN NEUROLOGY, Part I and Part III, respectively...
September 2010: Seminars in Neurology
Paolo Curatolo
Recent progress in pediatric neurosciences has greatly increased the divide between the possibilities for diagnosis and intervention among developed countries and resource-poor countries, where child neurologists suffer from the lack of adequate training, the absence of a network with professionals around the world, and the shortage of infrastructure. The International Child Neurology Association (ICNA) is the only child neurology association that can deal with these important issues and promote the reduction of this gap...
November 2010: Journal of Child Neurology
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