Seoyeon Bok, Alisha R Yallowitz, Jun Sun, Jason McCormick, Michelle Cung, Lingling Hu, Sarfaraz Lalani, Zan Li, Branden R Sosa, Tomas Baumgartner, Paul Byrne, Tuo Zhang, Kyle W Morse, Fatma F Mohamed, Chunxi Ge, Renny T Franceschi, Randy T Cowling, Barry H Greenberg, David J Pisapia, Thomas A Imahiyerobo, Shenela Lakhani, M Elizabeth Ross, Caitlin E Hoffman, Shawon Debnath, Matthew B Greenblatt
Craniosynostosis is a group of disorders of premature calvarial suture fusion. The identity of the calvarial stem cells (CSCs) that produce fusion-driving osteoblasts in craniosynostosis remains poorly understood. Here we show that both physiologic calvarial mineralization and pathologic calvarial fusion in craniosynostosis reflect the interaction of two separate stem cell lineages; a previously identified cathepsin K (CTSK) lineage CSC1 (CTSK+ CSC) and a separate discoidin domain-containing receptor 2 (DDR2) lineage stem cell (DDR2+ CSC) that we identified in this study...
September 20, 2023: Nature