Chao Xue, Zhuo Wei, Ye Zhang, Ying Liu, Shuang Zhang, Qi Li, Ke Feng, Xiaoxiao Yang, Guangqing Liu, Yuanli Chen, Xiaoju Li, Zhi Yao, Jihong Han, Yajun Duan
Cytosolic thiouridylase 2 (CTU2) is an enzyme modifying transfer RNAs post-transcriptionally, which has been implicated in breast cancer and melanoma development. And we found CTU2 participated in hepatocellular carcinoma (HCC) progression here. HepG2 cells as well as xenograft nude mice model were employed to investigate the role of CTU2 in HCC development in vitro and in vivo respectively. Further, we defined CTU2 as a Liver X receptor (LXR) targeted gene, with a typical LXR element in the CTU2 promoter. CTU2 expression was activated by LXR agonist and depressed by LXR knockout...
April 17, 2024: Cell Biology and Toxicology