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https://www.readbyqxmd.com/read/29680857/evaluation-of-the-osteoclastogenic-process-associated-with-rank-rank-l-opg-in-odontogenic-myxomas
#1
M-D Gonzalez-Galvan, A Mosqueda-Taylor, R Bologna-Molina, A Setien-Olarra, X Marichalar-Mendia, J-M Aguirre-Urizar
BACKGROUND: Odontogenic myxoma (OM) is a benign intraosseous neoplasm that exhibits local aggressiveness and high recurrence rates. Osteoclastogenesis is an important phenomenon in the tumor growth of maxillary neoplasms. RANK (Receptor Activator of Nuclear Factor κappa B) is the signaling receptor of RANK-L (Receptor activator of nuclear factor kappa-Β ligand) that activates the osteoclasts. OPG (osteoprotegerin) is a decoy receptor for RANK-L that inhibits pro-osteoclastogenesis. The RANK / RANKL / OPG system participates in the regulation of osteolytic activity under normal conditions, and its alteration has been associated with greater bone destruction, and also with tumor growth...
April 22, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29672880/enamel-renal-syndrome-case-report
#2
Luiz Henrique Soares Torres, Sérgio Lins de-Azevedo-Vaz, Danielle Resende Camisasca Barroso, Daniela Nascimento Silva, Tânia Regina Grão Velloso, Liliana Aparecida Pimenta de Barros
AIMS: to describe a case in which dental changes were observed and investigation proceeded to consider Enamel-Renal-Syndrome (ERS), a rare disorder that associates amelogenesis imperfecta with nephrocalcinosis. CASE REPORT: an 11-year-old male patient upon intraoral examination revealed generalized gingival hyperplasia, a few teeth were absent clinically and the remaining ones were yellowish-brown in color. The enamel alterations were suggesting of amelogenesis imperfecta...
April 19, 2018: Special Care in Dentistry
https://www.readbyqxmd.com/read/29594991/-neurotrophin-3-promotes-osteogenic-differentiation-of-human-dental-follicle-cells
#3
Lei Wei, Ma Yue, Ren Aishu
OBJECTIVE: This study aims to investigate the effect of neurotrophin 3 (NT-3) on the osteogenic differentiation of human dental follicle cells (hDFCs). METHODS: hDFCs were isolated and cultured in vitro. Immunocytochemical staining was used to identify the origin of hDFCs. The effects of different NT-3 concentrations on hDFCs proliferation were detected by using CCK-8 assay. The alkaline phosphatase (ALP) activities and mRNA expression levels of bone morphogenetic protein-2 (BMP-2) and osteocalcin (OCN) were determined to investigate the effects of NT-3 on hDFCs osteogenesis...
February 1, 2018: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/29527327/dna-methylation-profile-is-associated-with-the-osteogenic-potential-of-three-distinct-human-odontogenic-stem-cells
#4
Tingting Ai, Jieni Zhang, Xuedong Wang, Xiaowen Zheng, Xueyan Qin, Qian Zhang, Weiran Li, Wei Hu, Jiuxiang Lin, Feng Chen
Among the various sources of human autologous stem cells, stem cells isolated from dental tissues exhibit excellent properties in tissue engineering and regenerative medicine. However, the distinct potential of these odontogenic cell lines remains unclear. In this study, we analyzed DNA methylation patterns to determine whether specific differences existed among three different odontogenic cell types. Using the HumanMethylation450 Beadchip, the whole genomes of human dental pulp stem cells (DPSCs), periodontal ligament stem cells (PDLSCs), and dental follicle progenitor cells (DFPCs) were compared...
2018: Signal Transduction and Targeted Therapy
https://www.readbyqxmd.com/read/29511365/scaps-regulate-differentiation-of-dfscs-during-tooth-root-development-in-swine
#5
Xiaoshan Wu, Lei Hu, Yan Li, Yang Li, Fu Wang, Ping Ma, Jinsong Wang, Chunmei Zhang, Canhua Jiang, Songlin Wang
The tooth root transmits and balances occlusal forces through the periodontium to the alveolar bone. The periodontium, including the gingiva, the periodontal ligament, the cementum and the partial alveolar bone, derives from the dental follicle (DF), except for the gingiva. In the early developmental stages, the DF surrounds the tooth germ as a sphere and functions to promote tooth eruption. However, the morphological dynamics and factors regulating the differentiation of the DF during root elongation remain largely unknown...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29498435/dental-follicle-mesenchymal-stem-cells-down-regulate-th2-mediated-immune-response-in-asthmatic-patients-mononuclear-cells
#6
D Genç, N Zibandeh, E Nain, M Gökalp, A O Özen, M K Göker, T Akkoç
BACKGROUND: Asthma is a chronic inflammatory disease in which inflammatory responses have the polarisation of CD4+ T cells to Th2 cells. Dental follicle mesenchymal stem cells (DFSCs) have strong anti-inflammatory properties comparable to other mesenchymal stem cells. OBJECTIVE: We investigated the immunomodulatory effects of DFSCs on CD4+ T helper cell responses of asthmatic patients and compared the results with those obtained with asthmatic subjects on immunotherapy and with healthy individuals...
March 2, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29498025/dental-stem-cells-in-bone-tissue-engineering-current-overview-and-challenges
#7
Pinar Ercal, Gorke Gurel Pekozer, Gamze Torun Kose
The treatment of bone that is impaired due to disease, trauma or tumor resection creates a challenge for both clinicians and researchers. Critical size bone defects are conventionally treated with autografts which are associated with risks such as donor site morbidity and limitations like donor shortage. Bone tissue engineering has become a promising area for the management of critical size bone defects by the employment of biocompatible materials and the discovery of novel stem cell sources. Mesenchymal stem cells (MSCs) can be isolated with ease from various dental tissues including dental pulp stem cells, stem cells from apical papilla, dental follicle stem cells, stem cells from human exfoliated deciduous teeth, periodontal ligament stem cells, gingival stem cells and tooth germ derived stem cells...
March 2, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29473525/oral-mucosal-stem-cells-human-immature-dental-pulp-stem-cells-and-hair-follicle-bulge-stem-cells-as-adult-stem-cells-able-to-correct-limbal-stem-cell-deficiency
#8
Nada Tarek Hassan Mohamed, Neveen Ahmed AbdelAziz
Adult stem cells are somatic stem cells distributed all over the body. They represent a promising future for regenera-tive medicine because of their multiple advantages as they are widely available, accessible, easily stored and manipulated to a wide range of cells and with minimal invasive extraction. This review describes three examples of adult stem cells: oral mucosal epithelial stem cells, human immature dental pulp stem cells and hair follicle bulge stem cells that show an ability to correct limbal stem cell deficiency, their isolation and cultivation methods, feeder layers, carriers, markers expressed, successfulness to regenerate the ocular surface and mimic the corneal function in LSCD...
February 23, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29435865/gene-expression-profiles-in-dental-follicles-from-patients-with-impacted-canines
#9
Pamela Uribe, Lena Larsson, Anna Westerlund, Maria Ransjö
Animal studies suggest that the dental follicle (DF) plays a major role in tooth eruption. However, the role of the DF during tooth impaction and related root resorptions in adjacent teeth is not clear. The hypothesis for the present study is that expression of regulatory factors involved in the bone remodelling process necessary for tooth eruption may differ between dental follicles from teeth with different clinical situations. We have analysed the gene expression profiles in the DF obtained from impacted canines, with (N = 3) or without (N = 5) signs of root resorption, and from control teeth (normal erupting teeth, mesiodens) (N = 3)...
February 12, 2018: Odontology
https://www.readbyqxmd.com/read/29357356/genetic-variants-in-pachyonychia-congenita-associated-keratins-increase-susceptibility-to-tooth-decay
#10
Olivier Duverger, Jenna C Carlson, Chelsea M Karacz, Mary E Schwartz, Michael A Cross, Mary L Marazita, John R Shaffer, Maria I Morasso
Pachyonychia congenita (PC) is a cutaneous disorder primarily characterized by nail dystrophy and painful palmoplantar keratoderma. PC is caused by mutations in KRT6A, KRT6B, KRT6C, KRT16, and KRT17, a set of keratin genes expressed in the nail bed, palmoplantar epidermis, oral mucosal epithelium, hair follicle and sweat gland. RNA-seq analysis revealed that all PC-associated keratins (except for Krt6c that does exist in the mouse genome) are expressed in the mouse enamel organ. We further demonstrated that these keratins are produced by ameloblasts and are incorporated into mature human enamel...
January 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29327669/advanced-3d-models-cultured-to-investigate-mesenchymal-stromal-cells-of-the-human-dental-follicle
#11
Nathalie Steimberg, Francesca Angiero, Davide Farronato, Angiola Berenzi, Gianguido Cossellu, Andrea Ottonello, Darnell Kaigler, Giovanna Mazzoleni
The human dental follicle (hDF) contains the developing tooth and is involved in regulating tooth maturation and eruption. To investigate the mesenchymal stromal cells of the dental follicle, 2 three-dimensional (3D) culture models were used, based on a dynamic bioreactor: the Rotary Cell Culture System (RCCS™) and the 3D culture of precursor cells isolated from follicular tissue (human dental follicle cells [hDFCs]). The hDFCs were obtained from impacted third molars of 20 patients. Two 3D culture models were tested...
March 2018: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/29235086/endothelial-expression-of-c-kit-and-cd68-in-dental-follicles-of-human-impacted-third-molars
#12
Mugurel Constantin Rusu, Aliona Rașcu, Mihai Dragomir Stoenescu
Periodontal tissue remnants of odontogenesis constitute the dental follicle (DF) which is actually considered a stem niche in adults. However, potentialities of local endothelia within this niche seem overlooked. We thus aimed at testing the endothelial cells expression of c-kit, the progenitor cells marker, and CD68, commonly regarded as a monocyte/macrophage marker, in human DFs. We performed an immunohistochemical study using these two markers which were applied on samples collected from ten adult patients...
December 13, 2017: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/29226129/the-relationship-between-dental-follicle-width-and-maxillary-impacted-canines-descriptive-and-resorptive-features-using-cone-beam-computed-tomography
#13
İlhan Metin Dağsuyu, Rıdvan Okşayan, Fatih Kahraman, Mehmet Aydın, İbrahim Şevki Bayrakdar, Mehmet Uğurlu
Objectives: To assess the relationship between dental follicle width and maxillary impacted canines' descriptive and resorptive features with three-dimensional (3D) cone-beam computed tomography (CBCT). Methods: The study comprised 102 patients with cone-beam computed tomography 3D images and a total of 140 impacted canines. The association between maxillary impacted canine dental follicle width and the variables of gender, impaction side (right and left), localization of impacted canine (buccal, central, and palatal), and resorption of the adjacent laterals was compared...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29209231/early-determination-of-the-periodontal-domain-by-the-wnt-antagonist-frzb-sfrp3
#14
Thimios A Mitsiadis, Pierfrancesco Pagella, Claudio Cantù
Odontogenesis results from the continuous and reciprocal interaction between cells of the oral epithelium and cranial neural crest-derived mesenchyme. The canonical Wnt signaling pathway plays a fundamental role in mediating these interactions from the earliest stages of tooth development. Here we analyze by in situ hybridization the expression patterns of the extracellular Wnt antagonist Frzb/Sfrp3 . Although Frzb is expressed in dental mesenchymal cells from the earliest stages of odontogenesis, its expression is absent from a tiny population of mesenchymal cells immediately adjacent to the invaginating dental epithelium...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29118330/molecular-spectrum-of-secretome-regulates-the-relative-hepatogenic-potential-of-mesenchymal-stem-cells-from-bone-marrow-and-dental-tissue
#15
Ajay Kumar, Vinod Kumar, Vidya Rattan, Vivekananda Jha, Arnab Pal, Shalmoli Bhattacharyya
Liver regeneration is a spontaneous process that occurs after liver injury, but acute liver failure is a complex and fatal disease which is difficult to treat. Cell-based therapies are promising alternative therapeutic approach for liver failure and different cell sources have been tested in this regard. We investigated the comparative hepatogenic potential of human bone marrow stem cells (BMSC) with stem cells derived from human dental pulp (DPSC), apical papilla (SCAP) and follicle (DFSC) during this study...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29053654/retrospective-analysis-of-jaw-biopsies-in-young-adults-a-study-of-1599-cases-in-southern-brazil
#16
K Silva, A Alves, M Correa, A Etges, A-C Vasconcelos, A-P Gomes, S Tarquinio
BACKGROUND: To evaluate the prevalence and the characteristics of jaw lesions diagnosed in young adults aged 20 to 30 years in a southern Brazil reference center, over a period of 25 years. And to analyze the concordance between clinical and histological diagnosis. MATERIAL AND METHODS: In this cross-sectional retrospective study, the biopsies files from this center were retrieved and data regarding sex, age, bone localization, clinical and histological diagnosis were collected...
November 1, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28990476/disruption-of-the-reproductive-axis-in-freshwater-fish-catla-catla-after-bisphenol-a-exposure
#17
Mehwish Faheem, Saba Khaliq, Khalid Pervaz Lone
Environmental estrogens such as bisphenol-A (BPA) cause reproductive disorders in many vertebrate species, especially fish. BPA is used extensively in the manufacture of plastic and plastic products, epoxy resins, and dental sealants. The presence of BPA in sewage and surface water raises a potential threat to aquatic populations. In the present study, we investigated the effects of BPA on ovarian histology and transcription of key genes involved in reproduction. Adult female Catla catla were exposed to graded concentrations of BPA (10, 100, 1000 µg/l) for 14 days...
October 2017: Zoological Science
https://www.readbyqxmd.com/read/28910727/gene-environment-interaction-does-fluoride-influence-the-reproductive-hormones-in-male-farmers-modified-by-er%C3%AE-gene-polymorphisms
#18
Qiang Ma, Hui Huang, Long Sun, Tong Zhou, Jingyuan Zhu, Xuemin Cheng, Lijv Duan, Zhiyuan Li, Liuxin Cui, Yue Ba
The occurrence of endemic fluorosis is derived from high fluoride levels in drinking water and industrial fumes or dust. Reproductive disruption is also a major harm caused by fluoride exposure besides dental and skeletal lesions. However, few studies focus on the mechanism of fluoride exposure on male reproductive function, especially the possible interaction of fluoride exposure and gene polymorphism on male reproductive hormones. Therefore, we conducted a cross-sectional study in rural areas of Henan province in China to explore the interaction between the estrogen receptor alpha (ERα) gene and fluoride exposure on reproductive hormone levels in male farmers living in the endemic fluorosis villages...
December 2017: Chemosphere
https://www.readbyqxmd.com/read/28815884/periodontal-ligament-like-tissue-regeneration-with-drilled-porous-decalcified-dentin%C3%A2-matrix-sheet-composite
#19
Ge Feng, Yan Wu, Yu Yong, Lan Huang, Shu An, Bo Hu, Jun Luo, Jinlin Song
OBJECTIVE: In this study, we constructed a composite by combining the human dental follicle cell sheet and a manual drilled porous decalcified dentin matrix that was used to construct ectopic tissue-engineered periodontal ligament-like tissues in renal capsules of nude mice. MATERIALS AND METHODS: Human dental follicle cells were harvested from human lower third molars and then embedded into a temperature-sensitive culture dish. These cells were then placed into frozen porous decalcified dentin matrix sheets and induced by 50 g/ml ascorbic acid...
August 16, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28770470/the-cell-cycle-regulator-protein-p16-and-the-cellular-senescence-of-dental-follicle-cells
#20
Christian Morsczeck, Markus Hullmann, Anja Reck, Torsten E Reichert
Cellular senescence is a restricting factor for regenerative therapies with somatic stem cells. We showed previously that the onset of cellular senescence inhibits the osteogenic differentiation in stem cells of the dental follicle (DFCs), although the mechanism remains elusive. Two different pathways are involved in the induction of the cellular senescence, which are driven either by the cell cycle protein P21 or by the cell cycle protein P16. In this study, we investigated the expression of cell cycle proteins in DFCs after the induction of cellular senescence...
August 2, 2017: Molecular and Cellular Biochemistry
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